88 results about "Sinomenine hydrochloride" patented technology

The invention discloses a sinomenine hydrochloride sustained release injection and a preparation method thereof. The sustained release injection comprises one of synthetic polymer nanometer sinomenine hydrochloride sustained release injection, natural polymer material microsphere sinomenine hydrochloride sustained release injection, lipid sinomenine hydrochloride sustained release injection, multivesicular liposome sinomenine hydrochloride sustained release injection and gelatin sinomenine hydrochloride sustained release injection. Various sinomenine hydrochloride sustained release injections prepared by the invention by different methods can prolong the acting time of drug, reduce drug administration times, keep stable blood concentration in vivo and reduce the toxic and side effects of the drug.

The invention provides a preparation method of sinomenine, comprising the process for preparing and refining a sinomenine crude product. The preparation method provided by the invention comprises the following steps of: wetting and percolating caulis sinomenii coarse powder with HCL (hydrochloric acid), and extracting and crystallizing the percolation liquid to obtain a sinomenine crude product; and adding ethanol or purified water in the sinomenine crude product and heating and refluxing till the sinomenine crude product is dissolved, adding active carbon for filtering, then cooling, crystallizing, filtering and cleaning a filter cake with ethanol till the filtrate is colorless, and thus obtaining the sinomenine. The preparation method is simple to operate, belongs to cold treatment completely without the need of needs heating in the extraction process; the yield is high, and mother liquid is treated simply; moreover, the preparation method is safe and reliable, causes low pollution and plays a positive effect on environmental protection because only inorganic acid and alkali and a mall amount of level-two toxicity solvent are used.

The invention relates to a sinomenine hydrochloride controlled release patch, a preparation method thereof and application thereof in treating arthritis, pain relief and the like. The patch comprises sinomenine hydrochloride, a framework material, plasticizing agent, crosslinking agent, antioxidant and solvent. The preparation method can release medicament to local focus parts at a control rate and ensures that the medicament maintains daylong therapeutic effect with little adverse reaction.

The invention provides a method for highly efficiently extracting sinomenine hydrochloride from caulis sinomenii. The method comprises the following steps: a caulis sinomenii raw material is added into a 0.1-1mol / L HCL solution, and is infiltrated for 6.5-30h; the mixture is respectively filled into 2-5 percolators connected in parallel, and is subjected to re-percolation extraction. The extraction method provided by the invention has the advantages of high extraction efficiency and low solvent dose. The method can be widely applied in the field of traditional Chinese medicine active component extraction.

The invention provides a preparation method of sinomenine hydrochloride. The method comprises the steps of: A) extraction: wetting caulis sinomenii coarse powder by using hydrochloric acid (HCl), installing a percolator, adding HCl for impregnation and percolation to obtain percolate; B) eluting treated cation exchange resin or 152 resin on the percolate by using ammonia water-ethanol solution or HCl with concentration being 3-10 percent, desalting, condensing and drying to obtain sinomenine hydrochloride crude products; and C) taking the sinomenine hydrochloride crude products, heating the crude products in ethanol or purified water for back flowing, condensing filtrate, cooling, crystallizing, filtering and using ethanol to wash a filter cake to obtain the sinomenine hydrochloride. Since the method adopts an absorbing process through the cation exchange resin or large-pore absorbing resin to replace the traditional extraction process through high-toxicity benzene and chloroform, the extraction rate is high, the method is simpler and convenient to operate, the harm and the pollution caused by high quantity of high-toxicity organic solvent to operator health and the environment can be avoided, the treatment process of the organic solvent is reduced, the environmental protection is further facilitated, the investment in environmental protection facilities of a factory is reduced and the environmental-friendly production is facilitated. The sinomenine hydrochloride prepared by adopting the method through extraction and separation can be used as a raw material for pharmaceutical preparations, the purity is higher, solvent residue does not exists and the potential harm to human bodies is reduced.

The invention discloses sinomenine hydrochloride and a preparation method thereof. According to the technical scheme, sinomenine hydrochloride is prepared with a single-stage extraction or multi-stageextraction method. The single-stage extraction is based on a single centrifugal extractor for extraction, a centrifugal extractor drum motor is started, a liquid medicine is pumped into the centrifugal extractor from a light phase inlet at a speed of 10000 L / h, an extraction agent chloroform is pumped into the centrifugal extractor from a heavy phase inlet at a speed of 7500 L / h, and extract liquor is collected; the multi-stage extraction is based on two or more centrifugal extractors for extraction in a series-connection manner.

A spray of diversine hydrochloride is prepared from the tuduranine hydrochloride, percutaneous promoter and solvent. Its advantages are high percutaneous effect and curative effect, quick absorption, and low toxic by-effect.

The invention discloses a method for extracting sinomenine hydrochloride from caulis sinomenii. The method comprises the following steps: crushing sinomenium acutum roots; sieving by a 40-mesh sieve; adding 5-8 times of a 60-70% ethanol liquid; extracting for 1-2 hours in a double frequency ultrasonic device; filtering and decompressing and concentrating; and purifying the filtrate by virtue of column chromatography on silica gel to obtain high purity sinomenine hydrochloride. The method disclosed by the invention is simple in process and high is recovery rate and the separated sinomenine hydrochloride is high in purity.

The sinomenine osmotic pump type control-released preparation capable of releasing a certain quantity of medicine at a constant releasing speed mainly is formed from main core, coating membrane and medicine-releasing hole, and its tablet core is composed of sinomenine hydrochloride, osmosis agent, filling agent and other medicinal auxiliary material, and the coating membrane is a cellulose acetate semi-permeable membrane, and is made up through the processes of pulverizing, sieving, coating and drying. The obtained control-release preparation uses the osmotic pressure difference between interior and exterior of the membrane as medicine-releasing power, and possesses the advantages of blood concentration equilibration, small side effect and long duration of drug effect, etc.

An orally applied slow-releasing micropill of tuduranine or its salt is composed of core and coated layer. Said core is prepared from tuduranine hydrochloride powder and fillers. Said coated layer is prepared from ethyl cellulose.

The invention discloses a sinomenine hydrochloride slow-release injection and a preparation method thereof. The slow-release injection comprises one of a synthetic high molecular polymer nanoparticle sinomenine hydrochloride slow-release injection, a natural high molecular material microsphere sinomenine hydrochloride slow-release injection, a liposome sinomenine hydrochloride slow-release injection, a multi-vesicle liposome sinomenine hydrochloride slow-release injection and a gel sinomenine hydrochloride slow-release injection. In the invention, various sinomenine hydrochloride slow-release injections prepared by different methods can prolong drug action time, reduce medication frequencies, maintain relatively stable in-vivo blood concentration and reduce toxic side effects of drugs.

The invention provides a method for preparing a sinomenine hydrochloride cataplasma. The method has the advantages that: sinomenine hydrochloride is prepared through percolation; the operation is simple; in an extraction process, heating is not required and cooling is performed; the yield is high; mother liquid is simply treated; and the method is safe and reliable, is low in pollution, and plays an active role inof protecting environment.

The invention relates to a green environmentally-friendly industrial sinomenine extraction and separation method, sinomenine aw material powder as a raw material is added with slaked lime accounting 10% by weight of the raw material for even mixing, then is sprayed to wet with water and placed for a plurality of hours for alkalization, the alkalized material is put into an extracting tank, and added with a certain amount of ethyl acetate solvent for refluxing and extracting for 3 times, the extract in the extracting tank is filtered and sucked into a concentrator for vacuum concentration, the concentrated liquid is placed in the extracting tank, hydrochloric acid is added for adjusting pH to 4-5 for extraction, the hydrochloric acid layer is released, activated carbon is used for decolorization, pH is adjusted to about 2, and the liquid is placed overnight for precipitation of sinomenine hydrochloride. The traditional high toxicity benzene extraction and chloroform extraction processes are substituted by use of ethyl acetate as the extraction solvent, the problems of pollution on the environment and harm on human and animal health of existing technology can be solved, and sinomenine hydrochloride product can be directly obtained without crystallization of a product in a crude extract.

The invention provides a preparation method of a sinomenine hydrochloride injection, which adopts the step of preparing sinomenine hydrochloride with a percolation method. The preparation method has the advantages that the method is simple in operation, cold treatment is employed and heating is obviated in an extraction process, the yield is high, mother liquor treatment is simple, and the methodhas good safety and reliability, low pollution and positive effect on environmental protection.

An application of tuduranine hydrochloride in preparing the medicines for treating cerebral glioma is disclosed.

The invention provides a method for preparing a sinomenine hydrochloride tablet. The method has the advantages that: sinomenine hydrochloride is prepared through percolation; the operation is simple; in an extraction process, heating is not required and cooling is performed; the yield is high; mother liquid is simply treated; and the method is safe and reliable, is low in pollution, and plays an active role inof protecting environment.

The invention provides an extractive preparation method of sinomenine hydrochloride in orienavine. The active component sinomenine in orienavine is converted to sinomenine hydrochloride under the condition of low-concentration hydrochloric acid, and water solubility is improved such that pure water can be used as a solvent. The active component sinomenine hydrochloride is dissolved out from orienavine by a leaching method; and pH of a leaching solution is regulated with alkali lye firstly, and then a flocculating agent is added to precipitate vegetable protein in the leaching solution step bystep. In the extractive preparation technology of sinomenine hydrochloride, working concentration of acid and alkali is reduced, sinomenine hydrochloride is prevented from being decomposed in the environment of high-concentration acid and alkali, and generation of new impurities in the final product is reduced. Yield of sinomenine hydrochloride prepared by the above method can reach 1.5% and aboveof yield of orienavine.

The invention discloses an automatic control method and device for repercolation for extracting sinomenine hydrochloride and relates to the technical field of the medicine industry. According to the scheme, a concentration sensor, a controller and a control valve are used, the concentration of a percolation liquid is detected by using the concentration sensor, the controller is used for controlling control valves on an outlet pipeline and / or an inlet pipeline according to detected concentration data to control a percolation liquid meeting concentration requirements to be output into a percolation liquid storage tank, a percolation liquid which does not meet the concentration requirements is fed into a percolation liquid tank of a next stage for continuous percolation operation, thus automatic control on the repercolation operation process of the sinomenine hydrochloride is achieved, the labor requirements and the labor cost can be reduced, the control precision can be improved, and development of the medicine industry can be improved.

The invention discloses a structure of a sinomenine derivative sino-wcj-43 shown in the formula (I), a preparation method and application of the structure in inflammatory diseases and aplastic anemia.The derivative relates to the synthetic novel structure derivative sino-wcj-43 with sinomenine hydrochloride as the raw material. The invention discloses a preparation method of sino-wcj-43 or pharmaceutically acceptable salt thereof. The preparation method is simple, and the derivative has obvious anti-inflammatory functions and the function of treating aplastic anemia, and can be applied to clinical treatment of the inflammatory diseases and aplastic anemia in a monomer or pharmaceutical composition mode. The formula (I) is shown in the description.

The invention discloses a sinomenine medicine resin slow-release suspension which is prepared by a sinomenine medicine resin micro-capsule and a pharmaceutical common suspensions; the sinomenine medicine resin micro-capsule is made from a sinomenine medicine resin and a coating material; and the coating material is a medical high molecular material or a high molecular insoluble medical auxiliary material with good water permeability. The invention further discloses a preparation method of the sinomenine medicine resin slow-release suspensions. The sinomenine medicine resin slow-release suspension has the good effects of being large in medicine carrying quantity and high in medicine use ratio.

The invention is concerned with the compound medicine for rheumatism therapy. It contents: Hydrochloride SINOMENINE, Zushima and other general supplementary materials to generate all kinds of formulation that is acceptable for clinic practical.

The invention relates to application of sinomenine hydrochloride in promoting apoptosis of mesangial cells. Particularly, sinomenine hydrochloride can alleviate autophagy, proliferation and fibrosis of the mesangial cells caused by LPS. A combination of sinomenine hydrochloride and an autophagy inhibitor can promote the apoptosis of the mesangial cells. According to the application of sinomenine hydrochloride and the application of the combination of sinomenine hydrochloride and the autophagy inhibitor, a research basis is provided for combined treatment of kidney fibrosis disease through Chinese and Western medicine, and a good clinical application prospect is achieved.

The invention provides a circulation extraction method of sinomenine hydrochloride from orientvine. The circulation extraction method comprises the following steps: taking orientvine raw materials and adding the orientvine raw materials to 0.1 to 1mol / L of an HCL solution to be soaked for 6.5 to 30h, and respectively placing into 2 to 5 percolators which are connected in parallel mutually to be percolated and extracted again. The extraction method disclosed by the invention is high in extraction efficiency, less in solvent volume, and can be widely applied to the extraction field of Chinese herbal effective components.

The invention provides a method for preparing a sinomenine hydrochloride slow release injection. The method has the advantages: a step for preparing sinomenine hydrochloride with a percolation method is adopted, so that operation is easy, heating is not required in the extracting process, and cold treatment is performed; the yield is high and a mother solution is easy to treat; and the sinomeninehydrochloride slow release injection is safe and reliable, has low pollution, and plays a positive role in protecting the environment.

The invention is concerned with the compound medicine for rheumatism therapy. It contents: Hydrochloride SINOMENINE, Zushima and other general supplementary materials to generate all kinds of formulation that is acceptable for clinic practical.

The invention discloses a method for preparing sinomenine hydrochloride infusion solutions and freeze-dried powder injections. The method disclosed by the invention adopts adsorption technique of cation exchange resin or macroporous adsorption resin to replace traditional benzene extraction and chloroform extraction technique that are more toxic, and is high in extraction rate and simpler in operation; and harm and pollution to operators and the environment produced by the large-quantity high-toxicity organic solvent can be overcame, the method reduces processes for treating the organic solvent, is more beneficial for environmental protection, reduces investment in environmental protection facilities of plants, and is beneficial for environment-friendly production. Sinomenine hydrochloride extracted and separated by the method disclosed by the invention is used as a raw material in pharmaceutical preparations, has higher purity and no residual solvent, and reduces the potential hazards to human body.

The invention discloses an ultraviolet spectrum technique based end point judgment method for the percolation process of caulis sinomenii, and belongs to the technical field of traditional Chinese medicine production process analysis. The method includes the following steps: (1) collecting spectrum information; (2) collection samples; (3) determining sinomenine hydrochloride concentrations in thesamples; (4) performing rejecting and dividing on the samples; (5) establishing a correction module; and (6) applying the model. The real-time determination of the sinomenine hydrochloride concentrations during the percolation process of caulis sinomenii can be realized without sampling and analyzing; bases of timely judging the end point of percolation can be provided; the process monitoring andvisualization of the percolation process can be realized; and foundations can be built for deeply understanding the percolation process and enhancing production quality control levels.

The present invention discloses one kind of Chinese medicine composition for treating rheumatism, rheumatoid arthritis and chronic nephritis and its preparation process. The medicine composition contains coculine hydrochloride, microcrystalline cellulose, hydromellose, sodium dodecyl sulfate, acrylic resin, talcum powder, etc. The preparation process includes preparing pill core with microcrystalline cellulose and coculine hydrochloride in eccentric coating and pelletizing machine; mixing sodium dodecyl sulfate, talcum powder, water and acrylic resin to prepare coating liquid; and preparing the Chinese medicine composition with the pill core and the coating liquid in the coating and pelletizing machine. The Chinese medicine composition has the functions of dispelling wind evil and wetness evil, promoting and dredging meridian and high controlled release effect of maintaining stable blood medicine concentration for long time.