17 results about "Sinomenine hydrochloride" patented technology

The invention discloses a low-temperature vacuum microwave freeze-dried sinomenine hydrochloride preparation and a preparation method thereof in the technical field of pharmaceutical preparations, and solves the problems of long drying time, high energy consumption and poor product stability in the traditional freeze-drying technology. A vacuum microwave collaborative freeze-drying technology is adopted, microwave internal heating is achieved through a 2.45 GHz magnetron microwave generator and a rectangular waveguide tube under the conditions that the vacuum degree is 20-30 Pa and the plate layer temperature ranges from-40 DEG C to-35 DEG C, the microwave power density in the primary drying stage ranges from 0.3 W / g to 0.5 W / g, the microwave power density in the secondary drying stage ranges from 0.1 W / g to 0.3 W / g, and collaborative control over the microwave power, the vacuum degree, the temperature and the time is achieved in cooperation with a quaternary coupling precise control system. The preparation contains 50 mg of sinomenine hydrochloride, 100 mg of mannitol and 10 mg of sodium carboxymethyl cellulose grafted modified polyvinylpyrrolidone, the residual moisture is controlled to be 0.4-0.6%, the activity retention rate is 94-96%, and the drying time is shortened to 12-16 hours.

The invention relates to a sinomenine hydrochloride loaded chlorcosan polysaccharide microneedle as well as a preparation method and application thereof, and belongs to the technical field of sinomenine hydrochloride microneedles. The chlorpeas polysaccharide microneedle comprises a needle tip layer and a backing layer, the needle tip layer is prepared by performing primary drying on a mixed aqueous solution containing sinomenine hydrochloride and chlorpeas polysaccharide, and the backing layer is prepared by performing secondary drying on a chlorpeas polysaccharide aqueous solution. The sinomenine hydrochloride loaded Jingui bean polysaccharide microneedle has enough mechanical strength to penetrate through the stratum corneum, has biodegradability and good biocompatibility, is small in skin irritation, has good skin permeability and high drug loading capacity, and has flexibility and adhesion due to the fact that the microneedle is backed. When in use, the micro-needle can be tightly adhered to a movable joint part, so that dissolution is promoted, the insertion efficiency of the micro-needle is improved, and the stability of transdermal drug delivery is ensured.

The invention belongs to the technical field of medicine detection, and particularly discloses a method for detecting related substances in sinomenine hydrochloride raw material medicine and application, and the method comprises the following steps: preparing a test solution; preparing a contrast solution; preparing a mixed impurity reference substance solution; according to the determination method, the five known impurities in the sinomenine hydrochloride raw material can be accurately and quantitatively analyzed, the impurity content of the sinomenine hydrochloride raw material can be more accurately and comprehensively reflected, and the quality of sinomenine hydrochloride can be better controlled.

The invention belongs to the technical field of traditional Chinese medicine separation and purification, and discloses a method for separating caulis sinomenii alkaloid by a microfiltration-ultrafiltration-nanofiltration-electrodialysis integrated membrane technology. An ultrafiltration membrane electrodialysis device is adopted, the ultrafiltration membrane electrodialysis device comprises an anode plate, a cathode plate and a membrane stack arranged between the anode plate and the cathode plate, and the membrane stack is formed by connecting n groups of electrodialysis units in series, the device sequentially comprises an anode, an anode chamber, [a cation exchange membrane, an acid chamber, an anion exchange membrane, a feeding chamber, an ultrafiltration membrane and a product chamber] n, a cation exchange membrane, a cathode chamber and a cathode from the anode to the cathode. According to the method, the maximum recovery rate of sinomenine hydrochloride can reach 84.1%, the recovery rate of magnoflorine can reach 68.2%, the method is a simple and efficient multi-membrane integrated separation method with low energy consumption and small pollution, and a new thought is provided for separation and purification in the field of traditional Chinese medicine alkaloids.

The invention discloses a method for simultaneously preparing R-double sinomenine and / or S-double sinomenine, which comprises the following steps: mixing a sinomenine hydrochloride solution and a potassium ferricyanide solution, adding alkali and stirring to obtain a precipitate, washing the precipitate until the washing solution is neutral, adding a hydrochloric acid solution, stirring and reacting until the washing solution is acidic, slightly standing until the precipitate is separated out, and carrying out suction filtration to obtain the R-double sinomenine and / or S-double sinomenine. And finally, adding activated carbon into the solution, preserving heat, decolorizing, carrying out suction filtration, adding an alkali solution into the filtrate, precipitating to obtain R-sinomenine or a mixture of R-sinomenine and S-sinomenine, and adding acid to separate out and precipitate to obtain S-sinomenine. The invention provides a method for preparing a mixture of R-sinomenine and S-sinomenine or an R-, S-sinomenine monomer by regulating and controlling the proportion of the potassium ferricyanide solution, the reaction is controllable, and few byproducts are generated by synthesis.

The invention discloses a sinomenine hydrochloride production wastewater membrane separation and purification device, and relates to the technical field of wastewater membrane separation and purification, the sinomenine hydrochloride production wastewater membrane separation and purification device comprises a support frame, two liquid conveying pipes are fixedly mounted on the support frame, a return pipe is fixedly communicated between the two liquid conveying pipes, and the two liquid conveying pipes are fixedly communicated with cylinders which are uniformly distributed in a linear manner; two bubble making assemblies are arranged in the backflow pipe, and pressure adjusting assemblies are arranged in the cylinder bodies. The device has the advantages that in the process of filtering and purifying sinomenine hydrochloride production wastewater, a large number of cavitation bubbles can be formed in the wastewater through the bubble making assembly, the self-cleaning effect of a ceramic membrane is improved through the bubbles, and the continuous filtration speed and effect of the ceramic membrane on the wastewater are improved; the pressure on the side of the ceramic membrane can be detected, and the pressure on the outer side of the ceramic membrane can be adaptively adjusted, so that the filtering effect and the self-cleaning effect of continuous cooperation of a plurality of ceramic membranes on wastewater are effectively ensured.

The application relates to the technical field of targeted drugs, and discloses a drug-loaded system for treating rheumatoid arthritis as well as a preparation method and application of the drug-loaded system. The drug-loaded system comprises sinomenine hydrochloride, prussian blue, a biomimetic membrane and phosphatidylated hyaluronic acid, the biomimetic membrane is wrapped on the surface of the prussian blue loaded with the sinomenine hydrochloride, the phosphatidylated hyaluronic acid is embedded on the surface of the biomimetic membrane, and the biomimetic membrane comprises red blood cell membranes and macrophage membranes. The drug-loaded system has good targeting inflammation joint capacity and good treatment effect.

This invention discloses a catalytic reaction device for wastewater from the production of sinomenine hydrochloride, belonging to the field of chemical wastewater treatment technology. It includes a tank with a sealed cover at the top, and a pressure detector connected to a controller at the top of the cover. An injection device for injecting reagents into the tank is located on the outside of the tank. The injection device includes an injection tank fixed to the tank, with a first pipe connected to the tank body at the top and a second pipe connected to the tank body at the bottom. During the reaction, the internal pressure of the tank accelerates the injection of reagents from the injection tank into the tank body. A first control valve connected to the controller is installed on the second pipe, controlling the opening and closing degree of the second pipe. This invention addresses the problem of effectively controlling the redox reaction in wastewater generated during the preparation of sinomenine hydrochloride, improving reaction safety while ensuring normal reaction operation.

The present invention discloses a ROS-enhanced liposome and its preparation method and application, which relates to the technical field of biomedical polymer materials and new dosage forms of pharmaceutical preparations. The liposome is composed of egg yolk lecithin, cholesterol and DSPE-mPEG. 2K The liposome is a membrane material prepared by a thin film dispersion extrusion method to encapsulate different drugs; wherein the drug is a ROS-responsive celecoxib dimer prodrug (CTC); or a combination of a ROS-responsive celecoxib dimer prodrug (CTC) and sinomenine hydrochloride (SIN); or a combination of a ROS-responsive celecoxib dimer prodrug (CTC), sinomenine hydrochloride (SIN) and L-butionine-(S,R)-sulfoximine (L-BSO). The liposome not only has the advantages of good stability and long circulation time, but also can target and enrich RA tissues through ELVIS, release celecoxib in a high ROS environment, and then combine with sinomenine hydrochloride to achieve a combined therapeutic effect.

The invention discloses a catalytic reaction device for sinomenine hydrochloride production sewage, and belongs to the technical field of chemical sewage treatment.The catalytic reaction device comprises a tank body, a cover body is arranged at the top of the tank body in a sealed mode, a pressure detector is arranged at the top of the cover body, and the pressure detector is connected with a controller; a chemical injection device for injecting chemicals into the tank body is arranged on the outer side of the tank body, the chemical injection device comprises a chemical injection tank which is mutually fixed with the tank body, a first pipeline communicated with the tank body is arranged at the top of the chemical injection tank, and a second pipeline communicated with the tank body is arranged at the bottom of the chemical injection tank; in the reaction process, the pressure in the tank body pushes chemicals in the chemical injection tank to be injected into the tank body in an accelerated mode, a first control valve connected with the controller is arranged on the second pipeline, and the first control valve controls the opening degree of the second pipeline. The method is used for effectively controlling the oxidation-reduction reaction of sewage generated in the preparation process of sinomenine hydrochloride and improving the reaction safety under the condition that the reaction is normally carried out.

The invention provides a multi-release sinomenine hydrochloride sustained-release pellet preparation. The pellet preparation comprises a sustained-release pellet and an enteric-coated pellet in a mass ratio of 1: (1-5), the sustained-release pellet sequentially comprises a pellet core, a medicine carrying layer and a sustained-release layer from inside to outside, the enteric-coated pellet sequentially comprises a pellet core, a medicine carrying layer, a sustained-release layer, an isolating layer and an enteric-coated layer from inside to outside. The multi-release sinomenine hydrochloride sustained-release pellet preparation disclosed by the invention is formed by mixing a sustained-release pellet and an enteric-coated pellet, and the dissolution stability of the pellet preparation is good.

This invention belongs to the field of pharmaceutical preparation technology, specifically relating to a hyaluronic acid-modified co-supported nanoparticle, its preparation method, and its application. The nanoparticle has a core-shell structure, with the core being a coordination complex of zinc-doped Prussian blue and sinomenine hydrochloride, and the outer shell being a bovine serum albumin-hyaluronic acid conjugate. This invention improves the therapeutic effect on knee osteoarthritis.

The present invention discloses a method for optimizing the encapsulation of sinomenine hydrochloride (SH) in biocompatible vesicles using response surface analysis. The present invention uses SH as a model drug and screens out the delivery carrier with the best SH encapsulation rate: arginine decanoate vesicles [Arg][Dec]. Then, CCD response surface design is used to optimize the factors affecting the encapsulation of SH in [Arg][Dec] vesicles. The optimized [Arg][Dec] vesicle encapsulation rate is increased to 83.5%, and the centrifugal stability is increased to 90.4%. At the same time, the cumulative release rate of SH in [Arg][Dec] vesicles reaches more than 95% after 17 hours, and the cumulative skin penetration in [Arg][Dec] vesicles can reach 1665.59 μg / cm after 48 hours. 2 , with excellent in vitro skin penetration. This invention not only significantly improves the SH release rate and transdermal delivery effect, but also effectively saves experimental costs. It has potential application prospects in the treatment of local inflammation.

The invention aims to provide a refining process of a sinomenine hydrochloride bulk drug for injection, which comprises the following steps: taking 130-200 parts by volume of ethanol into a container, heating to reflux, adding the ethanol into a container containing 10 parts by weight of sinomenine hydrochloride, stirring, filtering while hot, cooling filtrate at 0-8 DEG C for crystallization, taking out after overnight, carrying out suction filtration, leaching filter residue with iced ethanol, and drying to obtain the sinomenine hydrochloride bulk drug for injection. And drying at 40 DEG C to obtain refined sinomenine hydrochloride. The refined sinomenine hydrochloride provided by the invention meets the impurity limit requirements of impurities (Q3A) in ICH new bulk drugs.

The invention discloses sinomenine hydrochloride solid lipid nanoparticles, gel, a preparation method and application, by exploring the preparation method of the sinomenine hydrochloride solid lipid nanoparticles HA-SH-SLNs, when the mass ratio of sinomenine hydrochloride to soya bean lecithin to hyaluronic acid modified targeting molecule DSPE-PEG-HA to poloxamer Pluronic F-68 is (0.3-0.7): (1-4): (0.0125-0.1): (1-4), the gel can be used for preparing the sinomenine hydrochloride solid lipid nanoparticles HA-SH-SLNs. The sinomenine hydrochloride solid lipid nanoparticles which are uniform in particle size, high in encapsulation efficiency, high in drug loading capacity and stable in quality are obtained, and the preparation method of the sinomenine hydrochloride solid lipid nanoparticle gel is further researched. The obtained sinomenine hydrochloride solid lipid nanoparticle gel HA-SH-SLNs-Gel is good in stability and small in hemolysis rate, the in-vivo residence time is longer than that of sinomenine hydrochloride solid lipid nanoparticles, the drug release period is delayed, and better articular cavity injection administration is facilitated.

The invention discloses a spray type temperature-sensitive in-situ gel external preparation as well as a preparation method and application thereof, and belongs to the technical field of pharmaceutical preparations, the spray type temperature-sensitive in-situ gel external preparation comprises the following components in percentage by weight: 2%-8% of sinomenine hydrochloride, 1%-5% of lidocaine hydrochloride, 14%-22% of a temperature-sensitive material, 0%-2% of a biological adhesive material, 0%-10% of a humectant, 0.01%-0.3% of a bacteriostatic agent, 0%-5% of a penetration enhancer and the balance of water; the temperature-sensitive material comprises 14%-20% of poloxamer 407 and 0%-2% of poloxamer 188, and the preparation is in a flowable solution state at the temperature of 30 DEG C or below and can be converted into a semi-solid gel state within 30 seconds when making contact with a surface at the temperature of 32 + / -0.5 DEG C. In clinical application, a dosage form which can realize'precise targeting and local treatment ', avoids the first-pass effect of the liver and is convenient and safe to use is developed.

The invention provides an optimized composition of raw material medicines and auxiliary materials of Zhengqingfengtongning injection, which is prepared from 25 parts by weight of sinomenine hydrochloride, 0.1-0.4 part by weight of EDTA-2Na (disodium edetate) and 1000 parts by volume of water by a conventional method. Research results prove that edetate disodium has a remarkable effect of inhibiting damage of an oxidizing agent to sinomenine hydrochloride, the total impurity amount is controlled to be 1% or below, and new impurities cannot be generated.