17 results about "Skin penetration" patented technology

The application belongs to the technical field of daily chemicals, and particularly relates to a high-temperature and mild alkyl glucoside sulfonate as well as a preparation method and application thereof. The alkyl glucoside sulfonate provided by the application is obtained by using the hydroxyl activity on the glucose unit of glucoside to perform chemical modification, and specifically, the alkyl glucoside is first subjected to intramolecular cross-linking by using 1,3-dichloro-2-propanol, and then subjected to anionization modification by using 3-chloro-2-hydroxypropanesulfonate sodium. The alkyl glucoside sulfonate prepared by the application has the advantages of mildness, low irritation, strong hard water resistance, good foaming performance, low skin penetration and small residual amount, can effectively solve the defects of strong penetration, strong deproteinization and delipidation, great damage to skin barrier and weak thickening effect of alkyl glucoside in personal cleaning products, and is very suitable for being widely used and popularized in daily chemicals.

To provide an oil-in-water emulsion skin cosmetic composition that exhibits excellent skin penetration and storage stability of water-soluble active ingredients. [Solution] An oil-in-water emulsion skin cosmetic composition comprising (A) a water-soluble active ingredient having a molecular weight of 700 Da or less, (B) an oil that is solid at 25°C, (C) one or more nonionic surfactants selected from polyglycerin fatty acid esters and polyoxyethylene alkyl ethers, (D) water, and (E) a higher alcohol having 18 to 22 carbon atoms, wherein the HLB value of one of the (C) components or a mixture of two or more of the (C) components is 8 to 12, and the ratio of the content of the (C) component to the content of the (E) component {(C) / (E)} is 0.4 to 1.3.

This invention discloses a snapshot-type hyperspectral three-dimensional skin imaging method and device, belonging to the field of biomedical imaging technology. The method includes: constructing a snapshot-type spectral-light field coupled imaging system containing a light source and an acquisition model; achieving full-domain skin illumination with broadband illumination; synchronously coupling and acquiring spectral and three-dimensional spatial information through the synergistic action of a lens group and a hyperspectral sensor to generate spectral coupled light field data; establishing a correlation dataset between the spectral coupled light field image and the hyperspectral light field image; training a spectral reconstruction network and solving the data; reconstructing the hyperspectral light field image and obtaining multi-view images through macro-pixel sampling; using a light field super-resolution network to improve image resolution; selecting the optimal skin penetration band image for stereo matching to obtain a target band depth map; and fusing the high-resolution center-view images from each channel with the target band depth map to complete the generation of a hyperspectral three-dimensional image. This invention achieves single-exposure hyperspectral three-dimensional imaging of the superficial skin layer.

This invention relates to the field of cosmetic technology, specifically to an antioxidant and repairing facial mask containing agarwood extract, comprising an essence and a modified bamboo fiber substrate. The essence is composed of the following ingredients: 1.5 to 2.5 parts modified agarwood extract, 1 to 1.8 parts carboxymethylated modified hyaluronic acid, 0.6 to 0.9 parts ceramide NP, 1.1 to 1.7 parts ascorbate glucoside, 5.5 to 7 parts glycerin, 3.5 to 4.5 parts propylene glycol, 0.15 to 0.25 parts thickener, 0.12 to 0.18 parts preservative, and 78 to 86 parts deionized water. In this invention, the addition of modified agarwood extract enhances the stability and antioxidant properties of the agarwood components, extending the product's shelf life. The addition of carboxymethylated modified hyaluronic acid improves skin penetration, allowing the essence components to penetrate deeply into the skin. The modified bamboo fiber substrate, working in conjunction with the essence, ensures its stability and facilitates the absorption of the agarwood components.

Some embodiments of a medical device anchor system include an anchor device that secures a medical instrument (such as a catheter or the like) in place relative to a skin penetration point using subcutaneous anchors. In some implementations, the medical instrument can be coupled to the anchor device using a snap-lock cap mechanism.

The application provides a gH625-H2A histone and chromatin and application thereof, the histone is that a peptide gH625 is added into histone H2A; the application comprises application of the gH625-H2A histone and chromatin in preparation of a drug or a drug delivery system and application of the gH625-H2A histone and chromatin in preparation of skin care products and cosmetics; the application provides the gH625-H2A histone and chromatin; the histone and the chromatin have strong cell penetration and skin penetration effect; the histone and the chromatin are expected to promote development of a transdermal gene delivery system and biological drugs and skin care products; the biological drugs and the skin care products prepared by the application do not need physical or chemical intervention, and passive skin delivery of nucleic acids, small peptides, growth factors and enzymes is realized.

Some embodiments of a medical system include a catheter device, such as an intravenous cannula device, having an external anchor device and a subcutaneous anchor device to secure a distally extending cannula of the device in a selected position relative to a skin penetration point.

The application discloses a kind of collagen biomimetic inclusion and its preparation method and application, it is related to cosmetic technical field.The collagen is wrapped by using inner layer wrapping matrix and outer layer wrapping matrix to the recombinant I type humanized collagen and recombinant III type humanized collagen outside, the inner layer wrapping matrix includes hyaluronic acid-fucose crosslinking polymer, snail secretion filtrate;The outer layer wrapping matrix includes grape seed oil, ceramide NS, isopropyl palmitate, ethyl laurate, ethylhexyl cocoate.By carefully selecting the component of biomimetic inclusion, the wrapped collagen is little in loss amount, stable in property and good in skin penetration effect.

Provide improved means for transdermally delivering a pesticidal or other toxic agent from a composition containing the toxic agent to a target animal, particularly into its bloodstream. **Solution**: A composition for killing animals, such as rodents, comprising (i) one or more toxic agents toxic to the animal, such as cholecalciferol or 25-hydroxy cholecalciferol (vitamin D3), as a toxic component, and (ii) a carrier system for the toxic component, wherein the carrier system (ii) comprises (a) at least one solvent or dispersion medium for the toxic component, such as an alcohol like ethanol, and (b) at least one skin disrupting component, such as dimethyl sulfoxide (DMSO). The composition enhances the skin penetration of the toxicant into or through the skin of the animal where the composition is sprayed or delivered, for example, in a trap or other device. ​

The present application provides a Chinese medicine compound with hair growth and anti-hair loss effects and a hair care product containing the compound. The Chinese medicine compound comprises the following components by mass percentage: 44-65% of cypress leaf extract; 3-6% of agastache extract; 1-5% of medlar fruit extract; 0.5% of phenoxyethanol; and the rest is water and trace amount of additives, with the total amount being 100%. The compound is a functional liquid raw material which is standardized in extraction, compounding and stabilization. The components have the following synergistic effects: the cypress leaf plays a role in promoting blood circulation and providing nutrition to hair follicles; the agastache has anti-inflammatory effect, improves skin microcirculation and volatile components promote skin penetration; the medlar is rich in antioxidant components and polysaccharides, and has the effects of nourishing blood, antioxidant and protecting hair follicle cells. The three components have synergistic effects in inhibiting inflammation of hair follicles, promoting metabolism of hair papilla cells and prolonging the hair growth period.

This invention discloses a nanoparticle of *Gynostemma pentaphyllum*, its preparation method, and its application. The nanoparticle is obtained by microwave calcination and quenching with rice vinegar from *Gynostemma pentaphyllum*. The microwave calcination temperature is 600-850℃, and the calcination time is 10-30 min. The particle size (D90) of the *Gynostemma pentaphyllum* nanoparticle is 100-500 nm. This invention, by combining microwave calcination and rice vinegar quenching, significantly reduces the particle size of the pulverized *Gynostemma pentaphyllum* powder, thereby greatly improving its in vitro dissolution rate. Furthermore, after modification with an alternating magnetic field, the rice vinegar quenching solution exhibits improved skin penetration efficiency and can be used as a topical preparation for detoxification, antipruritic effects, and skin repair, thus reducing resource waste and meeting the requirements of green pharmaceutical manufacturing.

The present invention provides a skin stimulator in which a middle cover is provided between a top cover and a housing, so that a solution introduced via the top cover is dispersed while passing through the middle cover, thereby reducing loss of an active ingredient solution, and needles protrude from the middle cover toward a lower portion of the housing, so that the solution is introduced into the epidermal layer of the skin, thereby improving a skin penetration rate.

The present application belongs to the technical field of cosmetic and food raw materials, and particularly relates to a coffee peel extract, a preparation method of micro-molecular cluster water and application of the coffee peel extract in cosmetics or food. 17 The micro-molecular cluster water with O-NMR half-peak width less than 100 Hz is subjected to negative pressure cavitation extraction to obtain an extract material; the extract material is subjected to solid-liquid separation and then subjected to adsorption through a macroporous adsorption resin column to obtain an elution liquid; and the elution liquid is concentrated to obtain the coffee peel extract. The coffee peel extract provided by the present application is not only rich in active ingredients, but also has excellent effects of promoting the skin penetration of active ingredients, and has the characteristics of high safety, no irritation and promotion of digestion and absorption. The coffee peel extract can be applied in cosmetics or food without relying on or reducing the use of traditional chemical penetration enhancers, and can be widely applied in cosmetics or food, thereby having significant economic benefits.

This invention relates to a retinoic acid-alcohol amine complex, which is composed of retinoic acid and an alcohol amine compound. It is in liquid form at room temperature and has good water solubility / water dilution resistance and skin penetration effect. It overcomes the limitations of retinoic acid compounds in the field of pharmaceutical application in the prior art and has broad pharmaceutical prospects.

This invention relates to a composition for anti-skin aging and its application, belonging to the field of biomedical technology. The composition contains two core active ingredients: one is a single-domain antibody that targets and neutralizes human interleukin IL-6, the specific amino acid sequence of which is shown in SEQ ID NO:1; the other is a collagen hydrolysate peptide with a molecular weight of 2-5 kDa. This composition precisely inhibits the core inflammatory signal IL-6 driving aging through the single-domain antibody, while simultaneously replenishing the synthetic matrix and promoting repair using the collagen peptide, resulting in a synergistic effect. Experiments have demonstrated that this composition can significantly improve wrinkles and elasticity in photo-aged skin, promote collagen regeneration, and its collagen peptide component can effectively enhance the skin penetration efficiency of the single-domain antibody. This composition is suitable for preparing safe and effective topical anti-skin aging formulations.

This invention discloses an iontophoresis device and a method for iontophoresis delivery of an active composition, relating to the field of active ingredient penetration technology. The method includes: delivering a skin active composition to a target area using a composite pulse wave and / or a biphasic compensated pulse wave output by the iontophoresis device; the composite pulse wave, within a single cycle, sequentially includes a positive gradual rise segment, a negative main action segment, and a zero-recovery segment; the biphasic compensated pulse wave, within a single cycle, includes a negative main pulse and a positive compensated pulse. By employing a composite pulse wave and / or a biphasic compensated pulse wave to deliver the skin active composition to the target area, the problem of interfacial polarization accumulation is improved, and the delivery stability of the active substance is enhanced; by matching the waveform parameters of the active composition with the composite pulse wave and / or the biphasic compensated pulse wave used, the skin penetration of the active ingredient is increased; and by mixing the first and second substances immediately before use, the risk of inactivation of some active ingredients in a long-term aqueous environment is reduced.