340 results about "Skin penetration" patented technology

The invention relates to an alcohol-free cosmetic or pharmaceutical foam composition comprising water, a hydrophobic solvent, a surface-active agent, a gelling agent, an active component selected from the group of urea, hydroxy acid and a therapeutic enhancer and a propellant. The foam further comprises active agents and excipients with therapeutic properties having enhanced skin penetration.

Injection devices, systems and methods are disclosed for injecting two or more medicaments to a patient at a single injection site while preferably minimizing any mixing of the medicaments prior to delivery to the patient. The invention can also be used to sequentially deliver the medicaments to the patient in a repetitive manner. For example, the injection apparatus can sequentially provide a first medicament and then a second medicament to the patient during a first injection procedure. During a second injection procedure, the injection apparatus can again sequentially provide the first medicament and the second medicament to the patient either at the injection site of the first injection procedure or at a different injection site. Multi-lumen manifolds are disclosed for coupling to conventional drug ampoules, to permit the user to sequentially delivery different medicaments via a single skin penetration and to reduce losses associated with usage. Systems including multiple drug reservoirs and filling adaptors are also disclosed.

The invention describes novel formulations of nonsteroidal anti-inflammatory drugs (NSAIDs) based on complex aggregates with at least three amphipatic components suspended in a suitable, e.g. pharmaceutically acceptable, polar liquid medium. A suitably ionised NSAID is one of the two, amongst said three, components that tends to destabilise lipid membranes, the other system component with such activity being typically a surfactant. In contrast, the remaining amongst said at least three amphipatic components typically forms a stable lipid membrane on it's own. An essential characteristics of the resulting, relatively large, aggregates is an improved ability to penetrate pores, in a semi-permeable barrier, at least 30%, and often much smaller than the average diameter of the complex aggregate. This enables said aggregates to mediate NSAID transport through semi-permeable barriers including mammalian skin. As a result of the skin penetration by NSAID loaded large aggregates, the drug delivered transcutaneously with such carriers gets deeper into the tissue than the corresponding NSAID from a solution on the skin surface. This is believed to be due to the special ability of suitable large carriers to bypass the local sink of blood capillaries at the epidermal-dermal junction in the skin. The carrier-mediated delivery of locally applied NSAIDs thus allows therapy of deep tissues under the drug administration site, which is medically highly desirable.

The present invention provides a tnaluronidase. The hyaluronidase can be produced by the strain Streptomyces aitinocidm 77, Exemplary characteristics of the hyaluronidase include specific C-terminal or other amino acid sequences, including full-length sequences, and improved physico-chemical and actix itj properties as compared to known h> alυronidase preparatkiiis. Described are also various uses of the hyaiurυnidasc, including topical administration of the h> aiuronidasc to improve skin penetration of a co-administered active substance.

Topical alcoholic or aqueous alcoholic gels containing ibuprofen or other NSAIDs, such as, naproxen, in substantially neutral salt form, have enhanced penetration through skin and may provide rapid pain/inflammation relief by including in the formulation 2-n-nonyl-1,3-dioxolane or other hydrocarbyl derivative of 1,3-dioxolane-or 1,3-dioxane or acetal, as skin penetration enhancing compound. The amount of propylene glycol may be varied to adjust the initial flux of the NSAID through the skin, especially for ibuprofen, naproxen, and ketorolac.

The invention relates to a laminated microneedle system and a preparation method thereof and belongs to the technical field of medical devices. A laminated structure, namely an outer layer and an inner layer of a needle body, is prepared from a soluble natural polymer material or a high molecular polymer. The outer layer of the needle body for wrapping a target drug has good soundness, can easily penetrate keratoderma, can be rapidly dissolved in a skin environment rich in water, and exerts an effect of releasing the target drug. The inner layer of the needle body cannot penetrate skin and therefore is free of the target drug. The system can strengthen a skin penetration effect of the needle body and reduce waste of the target drug at the same time. A base of the system has better compression resistance, and the problem of frangibility of the base under pressure is improved. The preparation method is easy, avoids high-temperature treatment, facilitates keeping activity of the target drug and is easy and simple to operate.

The invention encompasses nanoparticle assemblies and methods for preparing nanoparticle and compositions comprising such nanoparticles for use in topical or skin applications. The invention further encompasses methods of complexing various molecular and cellular entities to the nanoparticles using the resulting nanoparticles of the invention as delivery devices. The nanoparticles can be used for a variety of applications, such as treating cancer, targeting tumors, reducing the toxicity of a drug in vivo, increasing the efficacy of a complexed agent in vivo, protecting a complexed agent against degradation, increasing skin penetration and retention of drugs, and enhancing the water solubility/dispersibility of a drug or other agent.

A hydroalcoholic topical pharmaceutical composition is provided comprising a therapeutically effective amount of a therapeutic agent comprising one or more selective cyclooxygenase-2 (COX-2) inhibitors or pharmaceutically acceptable salts or esters thereof solubilized in a solubilizing amount of a penetration vehicle system comprising a skin penetration enhancing effective amount of at least one monohydric alcohol and at least two non-volatile organic compounds selected from the group consisting of pyrrolidones, polyol ethers, polyols and mixtures thereof. Also provided is a process for its preparation.

Emulsions and creams containing ibuprofen effective for topical administration of the ibuprofen are provided without the presence of conventional O/W emulsifying agent. The emulsions and creams are formed by using the ibuprofen, in the form of its salt, as the O/W emulsifying agent. A minor amount of a W/O emulsifying agent may be included in the composition. Percutaneous delivery of ibuprofen is improved by using a skin penetration enhancing compound, such as 2-n-nonyl-1,3-dioxolane or decanaldimethyl acetal, as the oily phase of the emulsion.

The invention relates to a manufacturing method for healthcare pillow pillowcase cloth. The manufacturing method is characterized by including: weaving grey cloth, and adding, by weight, 800-920 parts of water, 15-25 parts of chrysanthemum, 10-20 parts of prepared Sichuan aconite root, 5-15 parts of root of angelica dahurica, 5-15 parts of kudzuvine root, 10-20 parts of Szechuan lovage rhizome, 6-12 parts of root of red-rooted salvia and 8-16 parts of ageratum into a pressure vessel for heating at the temperature ranging from 45 DEG C to 49 DEG C prior to heat preservation for 230-270 minutes; performing final treatment. Various traditional Chinese medicine compositions of natural Chinese herbal medicine for socking a pillowcase are mixed together, so that various medical effects are multiplied and work together, for example, the chrysanthemum has the effect of dispelling wind and clearing heat and improving eyesight and detoxifying; the prepared Sichuan aconite root has the effect of dispelling wind-cold, scattering wind-evil and warming menstruation and relieving pain; the root of angelica dahurica has the effect of relieving swelling and pain and treating neurasthenia headache; the kudzuvine root has the effect of generating Yang and relaxing muscles, relieving restlessness and quenching thirst and treating high blood pressure; the Szechuan lovage rhizome has the effect of promoting circulation of Qi and relieving depression and promoting blood circulation to arrest pain. The effective components of the medicine enter a human body by means of skin penetration, acupuncture point absorption, meridian transmission and the like.

A toroidal tape core is produced from magnetic sheets (1) which may have slits (4). In order to improve the behavior of the toroidal cores (3) at high frequencies, the magnetic sheets (1) have a high surface roughness. The surface roughness of each magnetic sheet (1) is at least equal to the skin penetration depth at the frequency being used.

The invention provides a compound clobetasol propionate liposome and a preparation thereof, which are mainly used for treating diseases such as psoriasis vulgaris, dermatitis, eczema and the like. The liposome prepared from neutral synthetic phospholipids, lipids with positive charges, and cholesterol can coat clobetasol propionate and vitamin A acid simultaneously, and is added with a cream substrate or gel substrate to be prepared into compound clobetasol propionate liposome cream or gel. Compared with the common cream, the liposome preparation has the advantages that: the amount of the medicine retained in skin is larger, the skin penetration rate is lower, the content of the medicine in local skin can be improved, the treatment index is improved, and transdermal absorption dose is reduced, so that the toxic and side effects of the medicine are reduced.

The invention relates to a moistening and moisturizing essence, which is prepared from the following components in percentage by weight: a component A: 20.1 to 31.3 percent of a moisturizer, 5 to 10 percent of thermal spring water and 0.48 to 0.7 percent of a preservative; a component B: 3.2 to 5.35 percent of a moistening agent; a component C: 0.08 percent of a solubilizer and 2 to 4 percent of an odor remover; a component D: 2.51 to 6.02 percent of a skin conditioning agent and 3.05 to 5.1 percent of a skin penetration promoter. The invention also discloses a preparation method for the moistening and moisturizing essence. The moistening and moisturizing essence is mild and nonirritating in component formula and high in skin penetration, and has synergistic effects, rapid and persistent moisturizing and moisture locking effects and the effects of obviously softening skin and delaying senescence, and the skin can be moistened most rapidly and effectively.

The present method involves the photodynamic treatment of hyperactive gland disorders. The method involves the topical administration of a photosensitizer composition comprising hydrophobic and/or lipophilic green porphyrins such as lemuteporfin, polyethylene glycol and skin penetration enhancers such as oleyl alcohol and TRANSCUTOL™ to affected skin and subsequent exposure of that skin to energy of a wavelength capable of activating the photosensitizer.

The invention provides for compositions for transdermal delivery of a therapeutic agent associated with a surface modified poly(amidoamine) PAMAM dendrimer, wherein the surface modified dendrimer increased skin penetration of the therapeutic agent. The invention particularly provides for compositions and methods for transdermal delivery of anticancer and chemo-preventive agents.

The present invention relates to a percutaneous implant abutment for bone anchored implant devices adapted to be anchored in the craniofacial region of a person, such as bone anchored hearing aids. The abutment comprises a skin penetration body having a skin contacting surface. The skin contacting surface has been modified.

Disclosed are compositions for skin care and their medicinal uses. The compositions are identical in lipid constituents and structural properties to that of human stratum corneum. They comprise the major constituents for the lipid lamellar of the stratum corneum, including ceramides, cholesterol and fatty acids, the major constituents for epidermal cell membranes, including phospholipids, and physiologically active substances, including phytosphingosine and its derivatives. Without causing side effects, the cream composition for skin care is of much better skin penetration and water-retention capacity than are conventional compositions comprised of ceramide and other components in forms different from those of human skin. In addition to providing inhibitory activity against skin microorganisms, the cream composition brings about an improvement in the wrinkle condition of the skin, so that it can be applied to cosmetics. Also, it can be used as a medicinal material for the therapeutic treatment of inflammation, such as thermic erythema caused by IR and/or UV light.

The present invention relates to a fusion protein comprising a skin-penetrating peptide, a polynucleotide encoding the fusion protein, an expression vector comprising the polynucleotide, a transformant comprising the expression vector, a method for preparing the fusion protein, a cosmetic composition for improving skin conditions, which comprises the fusion protein, and a pharmaceutical composition for external skin use, which comprises the fusion protein. The fusion protein of the invention comprises a skin-penetrating peptide bound to a physiologically active protein. The fusion protein significantly enhances the skin penetration and skin retention of the physiologically active protein while maintaining or enhancing the ability of the physiologically active protein to synthesize a material showing physiologically active effects. Thus, it can be widely used as an active ingredient in functional cosmetic compositions and pharmaceutical compositions for external skin use.

The invention discloses natural handmade soap with an acne removing function and a preparation method of the natural handmade soap. The natural handmade soap is prepared from the following raw materials in percent by weight: 0.2%-1.2% of a lithospermum alcohol extract, 0.5%-1.8% of a salvia alcohol extract, 0.2%-0.8% of borneol, 0.5%-2% of dipotassium glycyrrhizinate, 0.3%-0.6% of tea tree essential oil, 0.8%-4% of natural plant oil, 5%-25% of glycerinum, 0.1%-0.5% of hyaluronic acid and 70%-88% of sodium aliphatate. The medicinal compositions, namely the lithospermum extract and the salvia extract, in the formula have good acne removing and spot fading effects; the borneol has the effects of clearing away heat and toxic materials, preventing corrosion and promoting granulation; and the dipotassium glycyrrhizinate has anti-inflammatory and anti-allergic effects, and is matched with the tea tree essential oil which has antibacterial activity and an excellent skin penetration enhancing effect, so that the prepared handmade soap has the acne removing effect while cleaning the skin. The invention further provides the preparation method of the natural handmade soap.