134 results about "Skin penetration" patented technology

Some embodiments of a medical device anchor system include an anchor device that receives a catheter (or other medical instrument) and secures the catheter in place relative to a skin penetration point. In some embodiments, the anchor device can secure the catheter in an operative position relative to the skin without the use of sutures or skin tapes. In particular embodiments, the anchor device can be adjusted to a folded condition so that subcutaneous anchors are partially rotated prior to removal from the skin penetration point.

The invention relates to a decarboxylated carnosine derivative as well as a preparation method and application thereof. The structural formula of the decarboxylated carnosine derivative is shown as a formula (I), wherein R is selected from C5-C21 alkyl and C5-C21 unsaturated chain alkyl. Compared with decarboxylated carnosine, the decarboxylated carnosine derivative disclosed by the invention has a more excellent anti-saccharification effect; meanwhile, a relatively good anti-oxidation effect is achieved; moreover, the decarboxylated carnosine derivative disclosed by the invention has certain lipophilicity, is relatively easy to penetrate through a skin cuticle, is good in skin permeability and relatively good in stability, can be used for preparing cosmetics for resisting saccharification, resisting oxidation, resisting skin aging and the like, and has an important market value. # imgabs0 #

The invention relates to a targeted supramolecular BAPs-PLGA nanoparticle as well as a preparation method and an application of the targeted supramolecular BAPs-PLGA nanoparticle. The nanoparticle is prepared through a microfluidic technology and an ultrasonic emulsification technology, PLGA is used as an oil phase, supramolecular BAPs is used as a water phase to form a primary emulsion, and then the primary emulsion and a water phase containing an emulsifier and supramolecular RGD form a multiple emulsion. According to the technology, the BAPs and the eutectic solvent (TG-DES) are combined to form a stable supramolecular structure, so that the solubility and the stability of the BAPs are remarkably improved. The supramolecular RGD is attached to the surface of the nanoparticle and endows the nanoparticle with targeting property, and the cellular uptake ability of the BAPs can be improved through NRP-1 mediated transendocytosis. According to the invention, the bioavailability of the BAPs can be improved, and a new solution is provided for a drug delivery system and skin penetration enhancement. In addition, the preparation method of the nanoparticles is simple, controllable in process, suitable for industrial production and wide in application prospect.

The present invention relates to a decarboxylated carnosine derivative, a preparation method thereof and an application. The structural formula of the decarboxylated carnosine derivative of the present invention is shown in formula (I), wherein R is selected from: C5-C 21 alkyl group, C5-C 21 unsaturated hydrocarbon group. The decarboxylated carnosine derivative of the present invention has a more excellent anti-glycation effect compared with decarboxylated carnosine; meanwhile, it has good antioxidant effect; and, the decarboxylated carnosine derivative of the present invention has certain lipophilicity, is relatively easy to penetrate through the skin cutin layer, has good skin penetration performance, and has good stability at the same time. It can be used for preparing cosmetics with anti-glycation, antioxidant, anti-skin aging and other functions, and has important market value#imgabs0#(I).

The invention provides a coin-sized, fully integrated and wearable continuous blood glucose monitoring (CGM) system in combination with frontier technologies in crossing fields of biosensors, minimally invasive tools, hydrogels and the like. The invention comprises the following three main parts: 1) an emerging biochemical amplifier, namely an organic electrochemical transistor (OECT), for improving the sensitivity and exceeding the traditional electrochemical sensor; 2) a microneedle array for sampling interstitial fluid (ISF), which reduces pain in the skin penetration process; and 3) a tough and viscous enzyme hydrogel film which can improve the reliability of glucose sensing on the skin. Different from a traditional CGM, the CGM (OECT-CGM) provided by the invention has high anti-noise capability, adjustable sensitivity and current regeneration capability due to the adoption of the OECT amplifier, so that long-term stable glucose sensing can be realized within a specific clinical range (1-20mM). The CGM provided by the invention can provide high and adjustable sensitivity, minimally invasive property and better wearable property at the same time, and also paves a way for developing the next generation of CGM.

This invention provides a coin-sized, fully integrated and wearable continuous glucose monitoring system (CGMs) via combining cutting-edge technologies from the intersecting fields of biosensors, minimally invasive tools, and hydrogels. The invention includes three major parts: 1) an emerging biochemical amplifier, the organic electrochemical transistor (OECT), to improve sensitivity beyond traditional electrochemical modules; 2) a microneedle array for interstitial-fluid (ISF) sampling with reduced pain during skin penetration; and 3) a tough, adhesive enzymatic-hydrogel-membrane to enhance reliability of glucose sensing on skin. Unlike conventional CGMs, the employed OECT amplifier empowers the CGM (OECT-CGMs) with a high anti-noise ability, an on-demand-tunable sensitivity and current regeneration ability, enabling long-term stable glucose sensing within specific clinical ranges (1˜20 mM). This work paves the way for the development of next-generation CGMs that can simultaneously deliver high and adjustable sensitivity, minimal invasiveness, and improved wearability.

The invention discloses a moxa stick containing traditional Chinese medicine components for treating infertility and a preparation method of the moxa stick, relates to the technical field of traditional Chinese medicine instruments, and mainly solves the technical problem of low skin permeation efficiency of the medicine components in the moxibustion process. According to the technical scheme, the preparation method comprises the following steps: preparing traditional Chinese medicine powder consisting of angelica sinensis, prepared rehmannia root, semen cuscutae, fructus lycii, ligusticum wallichii, rhizoma cyperi, salvia miltiorrhiza and borneol according to specific parts by mass, and controlling the average particle size to be 10-50 microns; the moxa and the traditional Chinese medicine powder are mixed according to the mass ratio of (3-5): 1 to form a medicine core layer; the periphery of the medicine core layer is wrapped with a pure moxa heat conduction layer with the thickness of 2-4 mm; and finally, wrapping the periphery of the heat conduction layer with a mulberry paper barrier layer with the thickness of 0.1-0.3 mm. Through the combined action of the three-layer structure, the medicine release and heat conduction path is optimized, the medicine transdermal efficiency is remarkably improved, and the high-efficiency traditional Chinese medicine moxa stick for treating infertility is prepared.

The topical composition is for application to a portion of skin at a locus of postsurgical pain and comprises: an amount of anti-inflammatory analgesic; an amount of muscle relaxant; an amount of neuropathic analgesic; an amount of anesthetic; and a carrier having skin penetration enhancement qualities.

A method for examining visible skin conditions is shown. A housing is located at a region of a skin condition and image data of the skin over this region is captured. Electric fields are generated that penetrate the skin over the region, such that an application of the apparatus produces image-related signals and electric field related signals for the same skin condition. Depth of skin penetration of the skin condition may be assessed by calculating surface area of the skin condition from the image data and determining volume of the skin condition from the electric field related signals and processing the calculated surface area in combination with the determined indication of volume to assess the depth of skin penetration. The electric field generating device may comprise a first dielectric substrate having a hole and the capturing step may be performed by a camera viewing the skin condition through this hole.

The utility model discloses a novel birthmark scar medicine skin penetration device which comprises an outer shell, an inner shell is installed on the lower side of the outer shell through a communicating pipe, a vibration needle is installed at the bottom of the communicating pipe through a telescopic installation plate assembly, and an adsorption layer is detachably installed at the bottom of the vibration needle. Vertical plates are fixedly connected to the left side and the right side of the top of the adsorption layer, a plurality of cylindrical clamping blocks extending to the outer side are slidably connected to an inner cavity of the inner shell, and long grooves used in cooperation with the cylindrical clamping blocks are formed in the surfaces of the vertical plates. The cylindrical clamping block is retracted into the inner cavity of the inner shell by sliding the cylindrical clamping block, so that the vertical plate is unlocked, and then the adsorption layer slides down to be separated from the lower end of the inner shell, so that the adsorption layer is quickly and conveniently disassembled and disinfected.

Some embodiments of a medical system include a subcutaneous anchor device that extends outwardly from side wall of an intravenous cannula so as to secure the intravenous cannula in a position relative to a skin penetration point.

The invention provides a heart rate detection system and a heart rate detection method, which can obtain biological information through irradiation of a plurality of near infrared rays, so that the biological information of an occupant can be stably obtained even in various environments such as daytime, night, sunset, sunrise, shadow, street lamps and the like. Furthermore, biological information based on hemoglobin absorption rates of different skin penetration depths is obtained by irradiating a plurality of near infrared rays, and the heart rate of an occupant is grasped based on a plurality of pieces of biological information, thereby minimizing noise and improving accuracy.

The present invention relates to a percutaneous absorption preparation for relieving pain and, more specifically, to a percutaneous absorption preparation having enhanced drug absorption efficacy. Every ingredient in the percutaneous absorption preparation according to the present invention is uniformly dispersed and does not aggregate, and thus a sufficient anti-inflammatory and pain-relieving efficacy of the drug can be continuously exhibited over a long period of time. In addition, the drug is percutaneously delivered in an amount sufficient for exhibiting efficacy while minimizing skin irritation, which is a disadvantage of percutaneous absorption preparations, and thus a high level of pain-relieving efficacy is exhibited. Moreover, skin penetration promotion in which a consistent amount of percutaneous drug absorption is sustained over a long period of time can be achieved, and thus side effects such as the hepatic first-pass effect in the body can be prevented.

The invention provides an anti-aging composition and a skin care product. The anti-aging composition is prepared from components in percentage by mass as follows: 5%-40% of hydroxypropyl tetrahydropyrantriol, 5%-40% of a skin feeling / rheology regulator and 2%-12% of a ternary compound, the ternary complex is prepared from the following raw materials: organic acid, amino acid and saccharides. The anti-aging composition provided by the embodiment of the invention can be used for improving the skin penetration of the hydroxypropyl tetrahydropyrantriol.

The application belongs to the technical field of daily chemicals, and particularly relates to a high-temperature and mild alkyl glucoside sulfonate as well as a preparation method and application thereof. The alkyl glucoside sulfonate provided by the application is obtained by using the hydroxyl activity on the glucose unit of glucoside to perform chemical modification, and specifically, the alkyl glucoside is first subjected to intramolecular cross-linking by using 1,3-dichloro-2-propanol, and then subjected to anionization modification by using 3-chloro-2-hydroxypropanesulfonate sodium. The alkyl glucoside sulfonate prepared by the application has the advantages of mildness, low irritation, strong hard water resistance, good foaming performance, low skin penetration and small residual amount, can effectively solve the defects of strong penetration, strong deproteinization and delipidation, great damage to skin barrier and weak thickening effect of alkyl glucoside in personal cleaning products, and is very suitable for being widely used and popularized in daily chemicals.

The invention discloses dandelion emplastrum as well as a preparation method and application thereof, and belongs to the technical field of biological extracts. The invention provides a dandelion extract, and a preparation method of the dandelion extract comprises the following steps: drying whole dandelion, soaking in distilled water for 0.5 h, heating twice, 2 h each time to obtain a water extract, and removing moisture to obtain the dandelion extract. The mass ratio of the whole dandelion herb to the distilled water is 1: 20. The moisture removal is that the water extract is dried by distillation in a water bath and then is dried at a constant temperature of 60 DEG C. The dandelion is prepared into the emplastrum, and the emplastrum has a good repairing effect when being used for repairing abdominal skin permeability and wound surfaces of rats. A scientific basis is provided for further development and research of dandelion external preparations, and a clinical basis is conveniently provided for research on treatment of local trauma.

1. The name of this design product: Radio frequency thermometer host. 2. The purpose of this product design: used for non-invasive skin penetration of essence, promoting essence absorption, skin surface cleansing, warm massage, physical massage, skin relaxation, and exfoliation. It is not for medical use. 3. The key point of the design of this product lies in its shape. 4. The picture or photo that best illustrates the design points: Stereoscopic drawing 1.

Apparatuses and methods configured to provide heat and cold to the skin along with a skin treatment to control rate of skin treatment flow to the skin are described. The disclosed apparatuses and methods include beneficially delaying the transition of skin treatments once skin penetration is achieved to improve the effectiveness of topical treatments to the skin. Accordingly, the disclosed apparatuses and methods are configured to enhance the benefits of topical treatments to the skin.

The invention discloses a high-concentration water-soluble salicylic acid supramolecular system and application thereof, and belongs to the technical field of supramolecules. The invention provides a water-soluble salicylic acid supramolecular system, and aims to solve the problem that in the prior art, the requirements of high drug loading capacity (gt; 30%), low irritation (soothing), continuous skin penetration and the like are difficult to synergistically meet. The invention aims to introduce a supramolecular technology to develop supramolecular salicylic acid which is high in drug loading capacity (more than or equal to 30wt%), is stable and uniform liquid at the low temperature of-5 DEG C, is low in irritation and has long-acting skin penetration and controlled release, so that the supramolecular salicylic acid has breakthrough significance in treatment of skin diseases and also has a good application prospect. The invention also finds that the supramolecular system can more effectively deliver salicylic acid to adipose tissues to enhance the metabolic regulation effect of salicylic acid, thereby providing an innovative solution for local weight loss.

In accordance with the present disclosure, there are provided formulations comprising:(a) at least one active agent;(b) an oil, and optionally a thickener therefor;(c) an organic solvent, and a thickener therefor; and(d) an oil and / or solvent soluble skin penetration enhancer;wherein:said formulation comprises <10 wt % water; andsaid formulation optionally forms a thixotropic thinning gel.Also provided are gels comprising oil and organic solvent, methods for preparing same and methods for the topical delivery of an active agent to a subject in need thereof.

1. The name of the design product: electrode patch. 2. The use of the design product: electrode patch; electrode patch for medicine penetration instrument to promote the penetration of medicine into human body through skin in the form of heating, pulse, etc. 3. The design points of the design product: in shape. 4. The picture or photo that best shows the design points: perspective view 1.

The utility model discloses skin penetration experiment reaction detection equipment, which relates to the technical field of skin penetration detection, and comprises a bottom plate, an adjusting mechanism is arranged above the bottom plate, the adjusting mechanism comprises a support block, the bottom surface of the support block is fixedly connected with the upper surface of the bottom plate, the inside of the support block is rotatably connected with a threaded rod, and the threaded rod is fixedly connected with the bottom plate. The outer surface of the threaded rod is in threaded connection with a lifting block, the lifting block is slidably connected to the interior of the supporting block, the front surface of the lifting block is fixedly connected with an auxiliary block, the interior of the auxiliary block is rotatably connected with a transmission rod, one end, away from the auxiliary block, of the transmission rod is fixedly connected with a detection equipment body, and the outer surface of the transmission rod is fixedly connected with an auxiliary gear. The skin penetration experiment reaction detection equipment has the adjusting capacity, the height and angle of the detection equipment can be adjusted according to different requirements of people with different heights, the situation that a detector feels uncomfortable when placing arms for multiple times for measurement is avoided, and the effect of improving the use effect of the skin penetration experiment reaction detection equipment is achieved.

The invention relates to the field of daily cosmetics, in particular to a preparation method and application of essence oil for repairing skin and reducing melanin. The essence oil for repairing the skin and reducing the melanin is prepared from a plant base oil system, a skin barrier repairing active matter, a whitening antioxidant active matter, natural plant essential oil and a skin penetration enhancing auxiliary agent, the preparation method adopts a three-phase step-by-step mixing, homogenizing and standing curing process, and effective construction of a penetration enhancing system and product stability are guaranteed. The composition has multiple excellent effects of repairing skin barriers, resisting inflammation, relieving and reducing melanin deposition, all the components have a synergistic effect, and the composition is natural, mild and suitable for preparing high-end skin care products.

To provide a novel penetration enhancer of royal jelly into skin.SOLUTION: A penetration enhancer into skin of 10-hydroxydecanoic acid and / or 10-hydroxy-2-decenoic acid contained in royal jelly, comprising, as an active ingredient, an (ammonium acryloyldimethyltaurate / methacrylic acid beheneth-25) crosspolymer.SELECTED DRAWING: Figure 1

The present invention relates to a liposome comprising graphene oxide having excellent skin penetration efficacy, and a cosmetic composition comprising the liposome, which has excellent liposome particle stability and excellent skin penetration efficacy, thereby exhibiting a superb effect on skin improvement.

The utility model discloses a pig skin cutting device for an in-vitro transdermal test, and aims to provide equipment capable of accurately cutting pig skins with different sizes so as to meet the requirements of the in-vitro transdermal test. The device is composed of a motor, a cutter assembly, a stand column, a flat plate, a fixing device and a control unit (containing a battery). Operation convenience is achieved through the labor-saving rebounding device on the stand column, and cutting accuracy and skin stability are ensured through the replaceable cutter assembly and the fixing device. In addition, due to the detachable design of the battery, the device is more portable and suitable for being used in different laboratory environments. According to the overall design, labor-saving performance of operation, cutting accuracy and portability of the device are considered, and the pig skin cutting device is suitable for pig skin cutting in an in-vitro transdermal test.

The invention relates to a double-layer dissolving microneedle patch loaded with bletilla striata polysaccharide and resveratrol and application of the double-layer dissolving microneedle patch, and belongs to the technical field of biomedical materials. The microneedle patch comprises a needle body layer and a backing layer, wherein the needle body layer contains bletilla striata polysaccharide and a hydroxypropyl-beta-cyclodextrin inclusion compound of resveratrol, and the backing layer is a bletilla striata polysaccharide matrix. The resveratrol is prepared into the cyclodextrin inclusion compound, so that the water solubility and bioavailability of the cyclodextrin inclusion compound are remarkably improved; and a double-layer structural design is utilized, so that the cooperation of quick release and continuous action of the medicine is realized. The microneedle patch has good mechanical strength, skin penetrability, biocompatibility and dissolvability, can effectively inhibit inflammation and promote cell migration, remarkably accelerates the healing process of full-thickness skin defects in an in-vivo experiment, and provides a novel efficient drug delivery system for treatment of wound surfaces difficult to heal.

Some embodiments of a medical device anchor system include an anchor device that receives a catheter (or other medical instrument) and secures the catheter in place relative to a skin penetration point. In some embodiments, the anchor device can secure the catheter in an operative position relative to the skin without the use of sutures or skin tapes. In particular embodiments, the anchor device can be adjusted to a folded condition so that subcutaneous anchors are partially rotated prior to removal from the skin penetration point.

Microcapsules contain a peptide (I), and peptides (II) or (III) coupled to a PLGA-containing polymeric shell. The microcapsules can be used to enhance skin penetration of active ingredients encapsulated therein, particularly in the field of cosmetics. A process can be used for preparing the microcapsules, and compositions can contain said microcapsules. The microcapsules can be used as a transdermal delivery system for the active ingredients encapsulated therein.

An iontophoresis administration device includes: a power source, used to generate the pulsed direct current required to cause a medicinal agent to permeate an administration region of an organism, wherein the power source generates a forward pulsed direct current during a first time period and a reverse pulses direct current during a second period of time; a dielectric layer, configured to be in contact with the administration region, wherein the dielectric layer includes or has attached thereto an active agent that is to permeate the administration region via a pulsed direct current; and at least two electrodes, used to receive the pulsed direct current outputted by the power source, facilitating the provision of the received pulsed direct current to the dielectric layer. The iontophoresis administration device provided by the present disclosure not only increases the skin permeation rate, but is also not likely to irritate or harm the skin.