80 results about "Skin penetration" patented technology

The invention discloses a moxa stick containing traditional Chinese medicine components for treating infertility and a preparation method of the moxa stick, relates to the technical field of traditional Chinese medicine instruments, and mainly solves the technical problem of low skin permeation efficiency of the medicine components in the moxibustion process. According to the technical scheme, the preparation method comprises the following steps: preparing traditional Chinese medicine powder consisting of angelica sinensis, prepared rehmannia root, semen cuscutae, fructus lycii, ligusticum wallichii, rhizoma cyperi, salvia miltiorrhiza and borneol according to specific parts by mass, and controlling the average particle size to be 10-50 microns; the moxa and the traditional Chinese medicine powder are mixed according to the mass ratio of (3-5): 1 to form a medicine core layer; the periphery of the medicine core layer is wrapped with a pure moxa heat conduction layer with the thickness of 2-4 mm; and finally, wrapping the periphery of the heat conduction layer with a mulberry paper barrier layer with the thickness of 0.1-0.3 mm. Through the combined action of the three-layer structure, the medicine release and heat conduction path is optimized, the medicine transdermal efficiency is remarkably improved, and the high-efficiency traditional Chinese medicine moxa stick for treating infertility is prepared.

A method for examining visible skin conditions is shown. A housing is located at a region of a skin condition and image data of the skin over this region is captured. Electric fields are generated that penetrate the skin over the region, such that an application of the apparatus produces image-related signals and electric field related signals for the same skin condition. Depth of skin penetration of the skin condition may be assessed by calculating surface area of the skin condition from the image data and determining volume of the skin condition from the electric field related signals and processing the calculated surface area in combination with the determined indication of volume to assess the depth of skin penetration. The electric field generating device may comprise a first dielectric substrate having a hole and the capturing step may be performed by a camera viewing the skin condition through this hole.

The utility model discloses a novel birthmark scar medicine skin penetration device which comprises an outer shell, an inner shell is installed on the lower side of the outer shell through a communicating pipe, a vibration needle is installed at the bottom of the communicating pipe through a telescopic installation plate assembly, and an adsorption layer is detachably installed at the bottom of the vibration needle. Vertical plates are fixedly connected to the left side and the right side of the top of the adsorption layer, a plurality of cylindrical clamping blocks extending to the outer side are slidably connected to an inner cavity of the inner shell, and long grooves used in cooperation with the cylindrical clamping blocks are formed in the surfaces of the vertical plates. The cylindrical clamping block is retracted into the inner cavity of the inner shell by sliding the cylindrical clamping block, so that the vertical plate is unlocked, and then the adsorption layer slides down to be separated from the lower end of the inner shell, so that the adsorption layer is quickly and conveniently disassembled and disinfected.

Some embodiments of a medical system include a subcutaneous anchor device that extends outwardly from side wall of an intravenous cannula so as to secure the intravenous cannula in a position relative to a skin penetration point.

The invention provides an anti-aging composition and a skin care product. The anti-aging composition is prepared from components in percentage by mass as follows: 5%-40% of hydroxypropyl tetrahydropyrantriol, 5%-40% of a skin feeling / rheology regulator and 2%-12% of a ternary compound, the ternary complex is prepared from the following raw materials: organic acid, amino acid and saccharides. The anti-aging composition provided by the embodiment of the invention can be used for improving the skin penetration of the hydroxypropyl tetrahydropyrantriol.

The application belongs to the technical field of daily chemicals, and particularly relates to a high-temperature and mild alkyl glucoside sulfonate as well as a preparation method and application thereof. The alkyl glucoside sulfonate provided by the application is obtained by using the hydroxyl activity on the glucose unit of glucoside to perform chemical modification, and specifically, the alkyl glucoside is first subjected to intramolecular cross-linking by using 1,3-dichloro-2-propanol, and then subjected to anionization modification by using 3-chloro-2-hydroxypropanesulfonate sodium. The alkyl glucoside sulfonate prepared by the application has the advantages of mildness, low irritation, strong hard water resistance, good foaming performance, low skin penetration and small residual amount, can effectively solve the defects of strong penetration, strong deproteinization and delipidation, great damage to skin barrier and weak thickening effect of alkyl glucoside in personal cleaning products, and is very suitable for being widely used and popularized in daily chemicals.

The invention discloses a high-concentration water-soluble salicylic acid supramolecular system and application thereof, and belongs to the technical field of supramolecules. The invention provides a water-soluble salicylic acid supramolecular system, and aims to solve the problem that in the prior art, the requirements of high drug loading capacity (gt; 30%), low irritation (soothing), continuous skin penetration and the like are difficult to synergistically meet. The invention aims to introduce a supramolecular technology to develop supramolecular salicylic acid which is high in drug loading capacity (more than or equal to 30wt%), is stable and uniform liquid at the low temperature of-5 DEG C, is low in irritation and has long-acting skin penetration and controlled release, so that the supramolecular salicylic acid has breakthrough significance in treatment of skin diseases and also has a good application prospect. The invention also finds that the supramolecular system can more effectively deliver salicylic acid to adipose tissues to enhance the metabolic regulation effect of salicylic acid, thereby providing an innovative solution for local weight loss.

In accordance with the present disclosure, there are provided formulations comprising:(a) at least one active agent;(b) an oil, and optionally a thickener therefor;(c) an organic solvent, and a thickener therefor; and(d) an oil and / or solvent soluble skin penetration enhancer;wherein:said formulation comprises <10 wt % water; andsaid formulation optionally forms a thixotropic thinning gel.Also provided are gels comprising oil and organic solvent, methods for preparing same and methods for the topical delivery of an active agent to a subject in need thereof.

1. The name of the design product: electrode patch. 2. The use of the design product: electrode patch; electrode patch for medicine penetration instrument to promote the penetration of medicine into human body through skin in the form of heating, pulse, etc. 3. The design points of the design product: in shape. 4. The picture or photo that best shows the design points: perspective view 1.

The invention relates to the field of daily cosmetics, in particular to a preparation method and application of essence oil for repairing skin and reducing melanin. The essence oil for repairing the skin and reducing the melanin is prepared from a plant base oil system, a skin barrier repairing active matter, a whitening antioxidant active matter, natural plant essential oil and a skin penetration enhancing auxiliary agent, the preparation method adopts a three-phase step-by-step mixing, homogenizing and standing curing process, and effective construction of a penetration enhancing system and product stability are guaranteed. The composition has multiple excellent effects of repairing skin barriers, resisting inflammation, relieving and reducing melanin deposition, all the components have a synergistic effect, and the composition is natural, mild and suitable for preparing high-end skin care products.

The utility model discloses a pig skin cutting device for an in-vitro transdermal test, and aims to provide equipment capable of accurately cutting pig skins with different sizes so as to meet the requirements of the in-vitro transdermal test. The device is composed of a motor, a cutter assembly, a stand column, a flat plate, a fixing device and a control unit (containing a battery). Operation convenience is achieved through the labor-saving rebounding device on the stand column, and cutting accuracy and skin stability are ensured through the replaceable cutter assembly and the fixing device. In addition, due to the detachable design of the battery, the device is more portable and suitable for being used in different laboratory environments. According to the overall design, labor-saving performance of operation, cutting accuracy and portability of the device are considered, and the pig skin cutting device is suitable for pig skin cutting in an in-vitro transdermal test.

The invention relates to a double-layer dissolving microneedle patch loaded with bletilla striata polysaccharide and resveratrol and application of the double-layer dissolving microneedle patch, and belongs to the technical field of biomedical materials. The microneedle patch comprises a needle body layer and a backing layer, wherein the needle body layer contains bletilla striata polysaccharide and a hydroxypropyl-beta-cyclodextrin inclusion compound of resveratrol, and the backing layer is a bletilla striata polysaccharide matrix. The resveratrol is prepared into the cyclodextrin inclusion compound, so that the water solubility and bioavailability of the cyclodextrin inclusion compound are remarkably improved; and a double-layer structural design is utilized, so that the cooperation of quick release and continuous action of the medicine is realized. The microneedle patch has good mechanical strength, skin penetrability, biocompatibility and dissolvability, can effectively inhibit inflammation and promote cell migration, remarkably accelerates the healing process of full-thickness skin defects in an in-vivo experiment, and provides a novel efficient drug delivery system for treatment of wound surfaces difficult to heal.

An iontophoresis administration device includes: a power source, used to generate the pulsed direct current required to cause a medicinal agent to permeate an administration region of an organism, wherein the power source generates a forward pulsed direct current during a first time period and a reverse pulses direct current during a second period of time; a dielectric layer, configured to be in contact with the administration region, wherein the dielectric layer includes or has attached thereto an active agent that is to permeate the administration region via a pulsed direct current; and at least two electrodes, used to receive the pulsed direct current outputted by the power source, facilitating the provision of the received pulsed direct current to the dielectric layer. The iontophoresis administration device provided by the present disclosure not only increases the skin permeation rate, but is also not likely to irritate or harm the skin.

1. The name of the design product: disposable penetration device consumables. 2. The use of the design product: for skin penetration absorption. 3. The design points of the design product: in shape. 4. The picture or photo that best shows the design points: perspective view. 5. The back of the design product is not easy to see or not visible during use, omit the rear view.

The invention belongs to the technical field of pharmaceutical preparations, and particularly discloses a colchicine external nano latex agent as well as a preparation method and application thereof.The colchicine external nano latex agent is prepared from the following raw materials in percentage by mass: 0.1%-1.2% of colchicine, 0.5%-25% of an oil phase matrix, 2%-20% of a surfactant, 2%-15% of a cosurfactant, 0%-15% of a transdermal absorption enhancer, 3%-3.5% of a gel matrix, 0%-0.5% of a pH regulator and the balance of water, totaling 100%. According to the colchicine external nano latex agent, the optimal prescription is obtained by applying a pseudo-ternary phase diagram and combining with D-optimal mix design, the particle size of the nano emulsion is stably controlled to be about 14 nm, and the small particle size means faster Brownian movement and stronger penetration of skin cuticle gaps or improvement of the infiltration capacity through appendages such as hair follicles, so that the colchicine external nano latex agent has a good application prospect. The skin penetration efficiency is higher than that of other prescriptions with larger particle sizes, and the nanoemulsion with small particle size hardly shows lag time.

To provide an oil-in-water emulsion skin cosmetic composition that exhibits excellent skin penetration and storage stability of water-soluble active ingredients. [Solution] An oil-in-water emulsion skin cosmetic composition comprising (A) a water-soluble active ingredient having a molecular weight of 700 Da or less, (B) an oil that is solid at 25°C, (C) one or more nonionic surfactants selected from polyglycerin fatty acid esters and polyoxyethylene alkyl ethers, (D) water, and (E) a higher alcohol having 18 to 22 carbon atoms, wherein the HLB value of one of the (C) components or a mixture of two or more of the (C) components is 8 to 12, and the ratio of the content of the (C) component to the content of the (E) component {(C) / (E)} is 0.4 to 1.3.

Some embodiments of a medical system include a subcutaneous anchor device that extends outwardly from side wall of an intravenous cannula so as to secure the intravenous cannula in a position relative to a skin penetration point.

This invention discloses a soothing and oil-controlling composition, its preparation method, and its application. The aim is to provide a composition that effectively increases bioavailability, promotes skin penetration of baicalin, reduces the dosage of baicalin, and possesses soothing and oil-controlling properties. It also provides a method for preparing the extract of the composition that improves extraction rate, promotes mutual solubility, is easily implemented on a production line, facilitates large-scale production, and produces a high-clarity and highly stable extract. The technical solution includes 150-200 parts of Scutellaria baicalensis and 40-80 parts of Corydalis yanhusuo; it belongs to the field of cosmetic technology.

This invention discloses a snapshot-type hyperspectral three-dimensional skin imaging method and device, belonging to the field of biomedical imaging technology. The method includes: constructing a snapshot-type spectral-light field coupled imaging system containing a light source and an acquisition model; achieving full-domain skin illumination with broadband illumination; synchronously coupling and acquiring spectral and three-dimensional spatial information through the synergistic action of a lens group and a hyperspectral sensor to generate spectral coupled light field data; establishing a correlation dataset between the spectral coupled light field image and the hyperspectral light field image; training a spectral reconstruction network and solving the data; reconstructing the hyperspectral light field image and obtaining multi-view images through macro-pixel sampling; using a light field super-resolution network to improve image resolution; selecting the optimal skin penetration band image for stereo matching to obtain a target band depth map; and fusing the high-resolution center-view images from each channel with the target band depth map to complete the generation of a hyperspectral three-dimensional image. This invention achieves single-exposure hyperspectral three-dimensional imaging of the superficial skin layer.

The invention discloses a bionic polypeptide nano-composite skin permeation carrier and a preparation method thereof. According to the carrier, a biodegradable high polymer material is used as a nano core, hydrophobic active ingredients are loaded, and a nano composite system with a bifunctional bionic shell is formed through covalent immobilization of bionic cell-penetrating peptide and biological adhesion peptide. The preparation method comprises three steps of oil / water emulsification volatilization nucleation, peptide coupling modification and freeze drying. The obtained carrier has the characteristics of actively penetrating a skin barrier and long-acting residence, the encapsulation efficiency reaches 85% or above, the steady-state transdermal rate is increased to 3.7 micrograms / cm < 3 > / h, and the drug leakage rate is lower than 7% after the carrier is stored for 30 days. By simulating the natural mechanism of skin permeation and adhesion, efficient encapsulation, steady-state release and deep delivery of active ingredients are realized, and the preparation method is suitable for the fields of transdermal drug delivery, skin repair, beauty and the like, and has good application prospects and industrialization potential.

The present application relates to the technical field of daily cosmetic composition, and more particularly to a delivery body of a composition for solving skin aging problem in multiple dimensions, comprising the following raw material components: phospholipid, cholesterol, edge activator, composition and water.The composition for solving skin aging problem in multiple dimensions comprises beta-arbutin, tranexamic acid, sodium hyaluronate, allantoin, vitamin B12 and hydroxyethyl urea.The present application further comprises a preparation for preparing a delivery body gel of the composition for solving skin aging problem in multiple dimensions, comprising the above-mentioned composition delivery body, carbomer and cosmetically acceptable adjuvants and solvents.The delivery body gel is convenient to use, easy to adhere to the skin, easy to apply, has strong skin penetration, can penetrate into deep skin, and has excellent synergistic antioxidant, anti-inflammatory, anti-black, anti-aging and other effects.

The invention belongs to the technical field of traditional Chinese medicine preparations, and discloses a preparation method of a Mongolian medicine patch. The patch is a multi-layer skeleton type transdermal drug delivery system and sequentially comprises a backing layer, a drug matrix layer and a protective layer from outside to inside, and the drug matrix layer is double-layer composite hydrogel composed of a drug storage layer and a controlled release layer; mango seeds, syzygium jambos and caesalpinia cristae serve as main medicine components, freeze-dried powder is obtained after water extraction, alcohol precipitation and freeze drying are conducted, the freeze-dried powder is mixed with a matrix containing a transdermal enhancer, and then the skin care product is prepared through the steps of sequential coating, pre-curing and the like. According to the patch, the chemical penetration enhancer is added into the matrix, so that the skin cuticle can be softened, the patch medicine is promoted to permeate into the skin, and the problem of low medicine absorption efficiency is effectively avoided.

The invention provides a three-layer freeze-drying slow-release negative-pressure mask as well as a preparation method and application thereof. The three-layer freeze-drying slow-release negative-pressure mask comprises a hydrophobic layer, a hydrophilic functional layer and a permeation-promoting slow-release layer which are sequentially stacked, the hydrophilic functional layer comprises mask cloth and functional components; the functional component is attached to one side, deviating from the hydrophobic layer, of the mask cloth. Through targeted structural design improvement, the mask has remarkable use advantages, the release rate of the functional components and the skin permeability can be better improved, and then the use effect of the mask is better.

This invention relates to the field of cosmetic technology, specifically to an antioxidant and repairing facial mask containing agarwood extract, comprising an essence and a modified bamboo fiber substrate. The essence is composed of the following ingredients: 1.5 to 2.5 parts modified agarwood extract, 1 to 1.8 parts carboxymethylated modified hyaluronic acid, 0.6 to 0.9 parts ceramide NP, 1.1 to 1.7 parts ascorbate glucoside, 5.5 to 7 parts glycerin, 3.5 to 4.5 parts propylene glycol, 0.15 to 0.25 parts thickener, 0.12 to 0.18 parts preservative, and 78 to 86 parts deionized water. In this invention, the addition of modified agarwood extract enhances the stability and antioxidant properties of the agarwood components, extending the product's shelf life. The addition of carboxymethylated modified hyaluronic acid improves skin penetration, allowing the essence components to penetrate deeply into the skin. The modified bamboo fiber substrate, working in conjunction with the essence, ensures its stability and facilitates the absorption of the agarwood components.

Some embodiments of a medical device anchor system include an anchor device that secures a medical instrument (such as a catheter or the like) in place relative to a skin penetration point using subcutaneous anchors. In some implementations, the medical instrument can be coupled to the anchor device using a snap-lock cap mechanism.

The invention discloses a plant nano-vesicle composition as well as a preparation method and application thereof, and belongs to the technical field of cosmetics. The plant nano-vesicle composition comprises perigord truffle nano-vesicles and centella asiatica nano-vesicles, wherein the mass ratio of the perigord truffle nano-vesicles to the centella asiatica nano-vesicles is (2-4): (1-3). The preparation method comprises the following steps: dispersing the perigord truffle nano-vesicles and the centella nano-vesicles in a solvent, mixing and compounding. According to the composition, the skin permeability of active ingredients is improved through the nano-vesicle carrier, the problems that in the prior art, plant extracts are poor in stability, low in skin permeability and single in effect are solved, the synergistic effect of tightening and anti-wrinkle of perigord truffle and relieving and repairing of centella asiatica is achieved, the moisturizing and whitening effects are achieved, the process is simple and convenient, stability is high, safety is good, and the composition is suitable for large-scale popularization and application. The composition is suitable for sensitive skin cosmetics and has a wide application prospect.

A retinoic acid-alcohol amine complex has retinoic acid and an alcohol amine compound. The complex is in liquid form at room temperature, has good water solubility / water dilution resistance and good skin penetration effect.

The present application relates to the technical field of personal care compositions, in particular to a tightening and lubricating composition and a preparation method and application thereof.The composition comprises the following components by mass fraction: modified fucoidan 5-15 parts, acetylated small molecule sodium hyaluronate 3-10 parts, oat beta-glucan 2-8 parts, hydrolyzed collagen peptide 2-6 parts, panthenol 1-5 parts, polyglycerol-10-lauric acid ester 1-4 parts, bis-ethylhexyloxyphenol methoxyphenyl triazine 0.5-2 parts, carnosine 0.3-1.5 parts, dipotassium glycyrrhizinate 0.1-1 part, trehalose 1-5 parts.The present application realizes the synergistic effect of instant lubrication, continuous moisturizing, tightening and moisturizing, and soothing and repairing by component compounding and fine preparation process, while ensuring mildness, effectively improving the stability and skin penetration efficiency of active ingredients.The composition can be used for preparing lubricants, intimate care products or functional skin care products.

The application provides a gH625-H2A histone and chromatin and application thereof, the histone is that a peptide gH625 is added into histone H2A; the application comprises application of the gH625-H2A histone and chromatin in preparation of a drug or a drug delivery system and application of the gH625-H2A histone and chromatin in preparation of skin care products and cosmetics; the application provides the gH625-H2A histone and chromatin; the histone and the chromatin have strong cell penetration and skin penetration effect; the histone and the chromatin are expected to promote development of a transdermal gene delivery system and biological drugs and skin care products; the biological drugs and the skin care products prepared by the application do not need physical or chemical intervention, and passive skin delivery of nucleic acids, small peptides, growth factors and enzymes is realized.

Some embodiments of a medical system include a catheter device, such as an intravenous cannula device, having an external anchor device and a subcutaneous anchor device to secure a distally extending cannula of the device in a selected position relative to a skin penetration point.