120 results about "Skin penetration" patented technology

The invention relates to a targeted supramolecular BAPs-PLGA nanoparticle as well as a preparation method and an application of the targeted supramolecular BAPs-PLGA nanoparticle. The nanoparticle is prepared through a microfluidic technology and an ultrasonic emulsification technology, PLGA is used as an oil phase, supramolecular BAPs is used as a water phase to form a primary emulsion, and then the primary emulsion and a water phase containing an emulsifier and supramolecular RGD form a multiple emulsion. According to the technology, the BAPs and the eutectic solvent (TG-DES) are combined to form a stable supramolecular structure, so that the solubility and the stability of the BAPs are remarkably improved. The supramolecular RGD is attached to the surface of the nanoparticle and endows the nanoparticle with targeting property, and the cellular uptake ability of the BAPs can be improved through NRP-1 mediated transendocytosis. According to the invention, the bioavailability of the BAPs can be improved, and a new solution is provided for a drug delivery system and skin penetration enhancement. In addition, the preparation method of the nanoparticles is simple, controllable in process, suitable for industrial production and wide in application prospect.

The present invention relates to a decarboxylated carnosine derivative, a preparation method thereof and an application. The structural formula of the decarboxylated carnosine derivative of the present invention is shown in formula (I), wherein R is selected from: C5-C 21 alkyl group, C5-C 21 unsaturated hydrocarbon group. The decarboxylated carnosine derivative of the present invention has a more excellent anti-glycation effect compared with decarboxylated carnosine; meanwhile, it has good antioxidant effect; and, the decarboxylated carnosine derivative of the present invention has certain lipophilicity, is relatively easy to penetrate through the skin cutin layer, has good skin penetration performance, and has good stability at the same time. It can be used for preparing cosmetics with anti-glycation, antioxidant, anti-skin aging and other functions, and has important market value#imgabs0#(I).

The invention provides a coin-sized, fully integrated and wearable continuous blood glucose monitoring (CGM) system in combination with frontier technologies in crossing fields of biosensors, minimally invasive tools, hydrogels and the like. The invention comprises the following three main parts: 1) an emerging biochemical amplifier, namely an organic electrochemical transistor (OECT), for improving the sensitivity and exceeding the traditional electrochemical sensor; 2) a microneedle array for sampling interstitial fluid (ISF), which reduces pain in the skin penetration process; and 3) a tough and viscous enzyme hydrogel film which can improve the reliability of glucose sensing on the skin. Different from a traditional CGM, the CGM (OECT-CGM) provided by the invention has high anti-noise capability, adjustable sensitivity and current regeneration capability due to the adoption of the OECT amplifier, so that long-term stable glucose sensing can be realized within a specific clinical range (1-20mM). The CGM provided by the invention can provide high and adjustable sensitivity, minimally invasive property and better wearable property at the same time, and also paves a way for developing the next generation of CGM.

This invention provides a coin-sized, fully integrated and wearable continuous glucose monitoring system (CGMs) via combining cutting-edge technologies from the intersecting fields of biosensors, minimally invasive tools, and hydrogels. The invention includes three major parts: 1) an emerging biochemical amplifier, the organic electrochemical transistor (OECT), to improve sensitivity beyond traditional electrochemical modules; 2) a microneedle array for interstitial-fluid (ISF) sampling with reduced pain during skin penetration; and 3) a tough, adhesive enzymatic-hydrogel-membrane to enhance reliability of glucose sensing on skin. Unlike conventional CGMs, the employed OECT amplifier empowers the CGM (OECT-CGMs) with a high anti-noise ability, an on-demand-tunable sensitivity and current regeneration ability, enabling long-term stable glucose sensing within specific clinical ranges (1˜20 mM). This work paves the way for the development of next-generation CGMs that can simultaneously deliver high and adjustable sensitivity, minimal invasiveness, and improved wearability.

The invention discloses a moxa stick containing traditional Chinese medicine components for treating infertility and a preparation method of the moxa stick, relates to the technical field of traditional Chinese medicine instruments, and mainly solves the technical problem of low skin permeation efficiency of the medicine components in the moxibustion process. According to the technical scheme, the preparation method comprises the following steps: preparing traditional Chinese medicine powder consisting of angelica sinensis, prepared rehmannia root, semen cuscutae, fructus lycii, ligusticum wallichii, rhizoma cyperi, salvia miltiorrhiza and borneol according to specific parts by mass, and controlling the average particle size to be 10-50 microns; the moxa and the traditional Chinese medicine powder are mixed according to the mass ratio of (3-5): 1 to form a medicine core layer; the periphery of the medicine core layer is wrapped with a pure moxa heat conduction layer with the thickness of 2-4 mm; and finally, wrapping the periphery of the heat conduction layer with a mulberry paper barrier layer with the thickness of 0.1-0.3 mm. Through the combined action of the three-layer structure, the medicine release and heat conduction path is optimized, the medicine transdermal efficiency is remarkably improved, and the high-efficiency traditional Chinese medicine moxa stick for treating infertility is prepared.

A method for examining visible skin conditions is shown. A housing is located at a region of a skin condition and image data of the skin over this region is captured. Electric fields are generated that penetrate the skin over the region, such that an application of the apparatus produces image-related signals and electric field related signals for the same skin condition. Depth of skin penetration of the skin condition may be assessed by calculating surface area of the skin condition from the image data and determining volume of the skin condition from the electric field related signals and processing the calculated surface area in combination with the determined indication of volume to assess the depth of skin penetration. The electric field generating device may comprise a first dielectric substrate having a hole and the capturing step may be performed by a camera viewing the skin condition through this hole.

The utility model discloses a novel birthmark scar medicine skin penetration device which comprises an outer shell, an inner shell is installed on the lower side of the outer shell through a communicating pipe, a vibration needle is installed at the bottom of the communicating pipe through a telescopic installation plate assembly, and an adsorption layer is detachably installed at the bottom of the vibration needle. Vertical plates are fixedly connected to the left side and the right side of the top of the adsorption layer, a plurality of cylindrical clamping blocks extending to the outer side are slidably connected to an inner cavity of the inner shell, and long grooves used in cooperation with the cylindrical clamping blocks are formed in the surfaces of the vertical plates. The cylindrical clamping block is retracted into the inner cavity of the inner shell by sliding the cylindrical clamping block, so that the vertical plate is unlocked, and then the adsorption layer slides down to be separated from the lower end of the inner shell, so that the adsorption layer is quickly and conveniently disassembled and disinfected.

Some embodiments of a medical system include a subcutaneous anchor device that extends outwardly from side wall of an intravenous cannula so as to secure the intravenous cannula in a position relative to a skin penetration point.

The invention provides a heart rate detection system and a heart rate detection method, which can obtain biological information through irradiation of a plurality of near infrared rays, so that the biological information of an occupant can be stably obtained even in various environments such as daytime, night, sunset, sunrise, shadow, street lamps and the like. Furthermore, biological information based on hemoglobin absorption rates of different skin penetration depths is obtained by irradiating a plurality of near infrared rays, and the heart rate of an occupant is grasped based on a plurality of pieces of biological information, thereby minimizing noise and improving accuracy.

The present invention relates to a percutaneous absorption preparation for relieving pain and, more specifically, to a percutaneous absorption preparation having enhanced drug absorption efficacy. Every ingredient in the percutaneous absorption preparation according to the present invention is uniformly dispersed and does not aggregate, and thus a sufficient anti-inflammatory and pain-relieving efficacy of the drug can be continuously exhibited over a long period of time. In addition, the drug is percutaneously delivered in an amount sufficient for exhibiting efficacy while minimizing skin irritation, which is a disadvantage of percutaneous absorption preparations, and thus a high level of pain-relieving efficacy is exhibited. Moreover, skin penetration promotion in which a consistent amount of percutaneous drug absorption is sustained over a long period of time can be achieved, and thus side effects such as the hepatic first-pass effect in the body can be prevented.

The invention provides an anti-aging composition and a skin care product. The anti-aging composition is prepared from components in percentage by mass as follows: 5%-40% of hydroxypropyl tetrahydropyrantriol, 5%-40% of a skin feeling / rheology regulator and 2%-12% of a ternary compound, the ternary complex is prepared from the following raw materials: organic acid, amino acid and saccharides. The anti-aging composition provided by the embodiment of the invention can be used for improving the skin penetration of the hydroxypropyl tetrahydropyrantriol.

The application belongs to the technical field of daily chemicals, and particularly relates to a high-temperature and mild alkyl glucoside sulfonate as well as a preparation method and application thereof. The alkyl glucoside sulfonate provided by the application is obtained by using the hydroxyl activity on the glucose unit of glucoside to perform chemical modification, and specifically, the alkyl glucoside is first subjected to intramolecular cross-linking by using 1,3-dichloro-2-propanol, and then subjected to anionization modification by using 3-chloro-2-hydroxypropanesulfonate sodium. The alkyl glucoside sulfonate prepared by the application has the advantages of mildness, low irritation, strong hard water resistance, good foaming performance, low skin penetration and small residual amount, can effectively solve the defects of strong penetration, strong deproteinization and delipidation, great damage to skin barrier and weak thickening effect of alkyl glucoside in personal cleaning products, and is very suitable for being widely used and popularized in daily chemicals.

The invention discloses dandelion emplastrum as well as a preparation method and application thereof, and belongs to the technical field of biological extracts. The invention provides a dandelion extract, and a preparation method of the dandelion extract comprises the following steps: drying whole dandelion, soaking in distilled water for 0.5 h, heating twice, 2 h each time to obtain a water extract, and removing moisture to obtain the dandelion extract. The mass ratio of the whole dandelion herb to the distilled water is 1: 20. The moisture removal is that the water extract is dried by distillation in a water bath and then is dried at a constant temperature of 60 DEG C. The dandelion is prepared into the emplastrum, and the emplastrum has a good repairing effect when being used for repairing abdominal skin permeability and wound surfaces of rats. A scientific basis is provided for further development and research of dandelion external preparations, and a clinical basis is conveniently provided for research on treatment of local trauma.

1. The name of this design product: Radio frequency thermometer host. 2. The purpose of this product design: used for non-invasive skin penetration of essence, promoting essence absorption, skin surface cleansing, warm massage, physical massage, skin relaxation, and exfoliation. It is not for medical use. 3. The key point of the design of this product lies in its shape. 4. The picture or photo that best illustrates the design points: Stereoscopic drawing 1.

The invention discloses a high-concentration water-soluble salicylic acid supramolecular system and application thereof, and belongs to the technical field of supramolecules. The invention provides a water-soluble salicylic acid supramolecular system, and aims to solve the problem that in the prior art, the requirements of high drug loading capacity (gt; 30%), low irritation (soothing), continuous skin penetration and the like are difficult to synergistically meet. The invention aims to introduce a supramolecular technology to develop supramolecular salicylic acid which is high in drug loading capacity (more than or equal to 30wt%), is stable and uniform liquid at the low temperature of-5 DEG C, is low in irritation and has long-acting skin penetration and controlled release, so that the supramolecular salicylic acid has breakthrough significance in treatment of skin diseases and also has a good application prospect. The invention also finds that the supramolecular system can more effectively deliver salicylic acid to adipose tissues to enhance the metabolic regulation effect of salicylic acid, thereby providing an innovative solution for local weight loss.

In accordance with the present disclosure, there are provided formulations comprising:(a) at least one active agent;(b) an oil, and optionally a thickener therefor;(c) an organic solvent, and a thickener therefor; and(d) an oil and / or solvent soluble skin penetration enhancer;wherein:said formulation comprises <10 wt % water; andsaid formulation optionally forms a thixotropic thinning gel.Also provided are gels comprising oil and organic solvent, methods for preparing same and methods for the topical delivery of an active agent to a subject in need thereof.

1. The name of the design product: electrode patch. 2. The use of the design product: electrode patch; electrode patch for medicine penetration instrument to promote the penetration of medicine into human body through skin in the form of heating, pulse, etc. 3. The design points of the design product: in shape. 4. The picture or photo that best shows the design points: perspective view 1.

The invention relates to the field of daily cosmetics, in particular to a preparation method and application of essence oil for repairing skin and reducing melanin. The essence oil for repairing the skin and reducing the melanin is prepared from a plant base oil system, a skin barrier repairing active matter, a whitening antioxidant active matter, natural plant essential oil and a skin penetration enhancing auxiliary agent, the preparation method adopts a three-phase step-by-step mixing, homogenizing and standing curing process, and effective construction of a penetration enhancing system and product stability are guaranteed. The composition has multiple excellent effects of repairing skin barriers, resisting inflammation, relieving and reducing melanin deposition, all the components have a synergistic effect, and the composition is natural, mild and suitable for preparing high-end skin care products.

To provide a novel penetration enhancer of royal jelly into skin.SOLUTION: A penetration enhancer into skin of 10-hydroxydecanoic acid and / or 10-hydroxy-2-decenoic acid contained in royal jelly, comprising, as an active ingredient, an (ammonium acryloyldimethyltaurate / methacrylic acid beheneth-25) crosspolymer.SELECTED DRAWING: Figure 1

The utility model discloses a pig skin cutting device for an in-vitro transdermal test, and aims to provide equipment capable of accurately cutting pig skins with different sizes so as to meet the requirements of the in-vitro transdermal test. The device is composed of a motor, a cutter assembly, a stand column, a flat plate, a fixing device and a control unit (containing a battery). Operation convenience is achieved through the labor-saving rebounding device on the stand column, and cutting accuracy and skin stability are ensured through the replaceable cutter assembly and the fixing device. In addition, due to the detachable design of the battery, the device is more portable and suitable for being used in different laboratory environments. According to the overall design, labor-saving performance of operation, cutting accuracy and portability of the device are considered, and the pig skin cutting device is suitable for pig skin cutting in an in-vitro transdermal test.

The invention relates to a double-layer dissolving microneedle patch loaded with bletilla striata polysaccharide and resveratrol and application of the double-layer dissolving microneedle patch, and belongs to the technical field of biomedical materials. The microneedle patch comprises a needle body layer and a backing layer, wherein the needle body layer contains bletilla striata polysaccharide and a hydroxypropyl-beta-cyclodextrin inclusion compound of resveratrol, and the backing layer is a bletilla striata polysaccharide matrix. The resveratrol is prepared into the cyclodextrin inclusion compound, so that the water solubility and bioavailability of the cyclodextrin inclusion compound are remarkably improved; and a double-layer structural design is utilized, so that the cooperation of quick release and continuous action of the medicine is realized. The microneedle patch has good mechanical strength, skin penetrability, biocompatibility and dissolvability, can effectively inhibit inflammation and promote cell migration, remarkably accelerates the healing process of full-thickness skin defects in an in-vivo experiment, and provides a novel efficient drug delivery system for treatment of wound surfaces difficult to heal.

Microcapsules contain a peptide (I), and peptides (II) or (III) coupled to a PLGA-containing polymeric shell. The microcapsules can be used to enhance skin penetration of active ingredients encapsulated therein, particularly in the field of cosmetics. A process can be used for preparing the microcapsules, and compositions can contain said microcapsules. The microcapsules can be used as a transdermal delivery system for the active ingredients encapsulated therein.

An iontophoresis administration device includes: a power source, used to generate the pulsed direct current required to cause a medicinal agent to permeate an administration region of an organism, wherein the power source generates a forward pulsed direct current during a first time period and a reverse pulses direct current during a second period of time; a dielectric layer, configured to be in contact with the administration region, wherein the dielectric layer includes or has attached thereto an active agent that is to permeate the administration region via a pulsed direct current; and at least two electrodes, used to receive the pulsed direct current outputted by the power source, facilitating the provision of the received pulsed direct current to the dielectric layer. The iontophoresis administration device provided by the present disclosure not only increases the skin permeation rate, but is also not likely to irritate or harm the skin.

1. The name of the design product: disposable penetration device consumables. 2. The use of the design product: for skin penetration absorption. 3. The design points of the design product: in shape. 4. The picture or photo that best shows the design points: perspective view. 5. The back of the design product is not easy to see or not visible during use, omit the rear view.

The invention belongs to the technical field of pharmaceutical preparations, and particularly discloses a colchicine external nano latex agent as well as a preparation method and application thereof.The colchicine external nano latex agent is prepared from the following raw materials in percentage by mass: 0.1%-1.2% of colchicine, 0.5%-25% of an oil phase matrix, 2%-20% of a surfactant, 2%-15% of a cosurfactant, 0%-15% of a transdermal absorption enhancer, 3%-3.5% of a gel matrix, 0%-0.5% of a pH regulator and the balance of water, totaling 100%. According to the colchicine external nano latex agent, the optimal prescription is obtained by applying a pseudo-ternary phase diagram and combining with D-optimal mix design, the particle size of the nano emulsion is stably controlled to be about 14 nm, and the small particle size means faster Brownian movement and stronger penetration of skin cuticle gaps or improvement of the infiltration capacity through appendages such as hair follicles, so that the colchicine external nano latex agent has a good application prospect. The skin penetration efficiency is higher than that of other prescriptions with larger particle sizes, and the nanoemulsion with small particle size hardly shows lag time.

To provide an oil-in-water emulsion skin cosmetic composition that exhibits excellent skin penetration and storage stability of water-soluble active ingredients. [Solution] An oil-in-water emulsion skin cosmetic composition comprising (A) a water-soluble active ingredient having a molecular weight of 700 Da or less, (B) an oil that is solid at 25°C, (C) one or more nonionic surfactants selected from polyglycerin fatty acid esters and polyoxyethylene alkyl ethers, (D) water, and (E) a higher alcohol having 18 to 22 carbon atoms, wherein the HLB value of one of the (C) components or a mixture of two or more of the (C) components is 8 to 12, and the ratio of the content of the (C) component to the content of the (E) component {(C) / (E)} is 0.4 to 1.3.

This application relates to the field of external-use medicines and specifically discloses a crisaborole aerosol and its preparation method. The crisaborole aerosol comprises crisaborole, a solvent, a non-aqueous solvent, a latent solvent, a film-forming agent, and a propellant. The composition comprises, by weight, 0.01% to 3.0% crisaborole, 20% to 60% non-aqueous solvent, 0.5% to 5.0% latent solvent, 0.1% to 5.0% film-forming agent, and 20% to 50% propellant. The solvent contains 10% to 30% water. A water-based aerosol, in particular, offers advantages over alcohol-based aerosols in terms of environmental friendliness, safety, and low irritation, as well as good stability and excellent skin penetration.

Some embodiments of a medical system include a subcutaneous anchor device that extends outwardly from side wall of an intravenous cannula so as to secure the intravenous cannula in a position relative to a skin penetration point.

This invention discloses a soothing and oil-controlling composition, its preparation method, and its application. The aim is to provide a composition that effectively increases bioavailability, promotes skin penetration of baicalin, reduces the dosage of baicalin, and possesses soothing and oil-controlling properties. It also provides a method for preparing the extract of the composition that improves extraction rate, promotes mutual solubility, is easily implemented on a production line, facilitates large-scale production, and produces a high-clarity and highly stable extract. The technical solution includes 150-200 parts of Scutellaria baicalensis and 40-80 parts of Corydalis yanhusuo; it belongs to the field of cosmetic technology.

This invention discloses a snapshot-type hyperspectral three-dimensional skin imaging method and device, belonging to the field of biomedical imaging technology. The method includes: constructing a snapshot-type spectral-light field coupled imaging system containing a light source and an acquisition model; achieving full-domain skin illumination with broadband illumination; synchronously coupling and acquiring spectral and three-dimensional spatial information through the synergistic action of a lens group and a hyperspectral sensor to generate spectral coupled light field data; establishing a correlation dataset between the spectral coupled light field image and the hyperspectral light field image; training a spectral reconstruction network and solving the data; reconstructing the hyperspectral light field image and obtaining multi-view images through macro-pixel sampling; using a light field super-resolution network to improve image resolution; selecting the optimal skin penetration band image for stereo matching to obtain a target band depth map; and fusing the high-resolution center-view images from each channel with the target band depth map to complete the generation of a hyperspectral three-dimensional image. This invention achieves single-exposure hyperspectral three-dimensional imaging of the superficial skin layer.