45 results about "Avenanthramide" patented technology

Methods and compositions for treating or preventing a skin condition, an inflammation, an irritation or an allergy associated with an ectoparasitic infection or infestation on an animal. The methods involve applying to the skin of the animal a pharmaceutical composition that contains a therapeutically effective amount of one or more than one avenanthramide, an optional ecto and / or endo-parasiticidal agent, and a pharmaceutically acceptable diluent or carrier

A method of preparing a highly dispersible whole grain oat flour by hydrolyzing, milling and agglomerating grain flour to arrive at a whole grain oat flour having an increased avenanthramide content compared to native oat flour.

Producing soluble oat flour with an increased level of avenanthramides by using enzymes to precondition whole oat flour prior to extrusion.

Methods and compositions are disclosed for inhibiting proliferation of human colon adenocarcinoma cells, reducing pro-inflammatory molecules, adhesion molecules, and vascular smooth muscle cell proliferation, and for increasing NO production. The present invention describes the use of phenolic compositions, purified from oats or synthetically produced, to decrease the effective amount of pro-inflammatory molecules and / or cell adhesion molecules. Alternatively, an alcoholic extract or concentrate from oats can be used. The methods of the present invention can be used as a treatment or prophylaxis of a wide variety of disorders associated with inflammatory states and / or with a lack of or need for nitric oxide (NO), such as inflammatory conditions, pain, free radical associated disorders, cardiovascular diseases, autoimmune disorders, pathological platelet aggregation, pathological vasoconstriction, vascular effects of diabetes, stroke, atherosclerosis, hypertension, abnormal vasospasm, and restenosis after angioplasty.

Methods for increasing the levels of avenanthramides in oats through false malting is disclosed. Oats are first subject to induction or enhancement of a secondary dormancy, and then malted for up to 5 days at an elevated temperature. The malted but not germinated oats are then dried and used as is, or further processed or milled to produce food, feed, nutraceutical or personal care products and ingredients. Methods are also provided for rendering non-dormant oats dormant and thus suitable for false malting.

Topical sanitizer includes avenanthramides, which is an active component of oats that is beneficial to the skin. The topical sanitizer is used preferably in conjunction with gloves that have an inner coating that includes avenanthramides. By using topical sanitizer that includes avenanthramides before and after wearing gloves, the skin of the person wearing the glove is more exposed to the beneficial avenanthramides all during the workday, not just when wearing gloves. The result is healthier, much softer and more comfortable skin on the hands.

The invention belongs to the field of daily-use chemicals, and discloses an extraction method and applications of oat avenanthramides. The method comprises the following steps: crushing oats, adding ethanol, evenly mixing and then adding enzyme, adjusting the pH value to be 5.0-6.0, performing enzymatic hydrolysis reaction under the stirring condition, centrifugally separating a reaction solution obtained after reaction is over, conducting subcritical extraction on solids obtained from centrifugal separation, and then recycling a solvent to obtain the oat avenanthramides extract. The method is simple and easy, conditions are easily controlled, the utilization rate of raw materials is high, and the industrial product is easily realized. Before extracting the oat avenanthramides, enzyme is added to perform pretreatment on oats, and the subcritical technology is used for extraction, so that the extraction rate of the oat avenanthramides is increased, and the time needed by extraction is shortened.

Methods and compositions are disclosed for reducing pro-inflammatory molecules, adhesion molecules, and vascular smooth muscle cell proliferation, and for increasing NO production. The present invention describes the use of phenolic compositions, purified from oats or synthetically produced, to decrease the effective amount of pro-inflammatory molecules and / or cell adhesion molecules. Alternatively, an alcoholic extract or concentrate from oats can be used. The methods of the present invention can be used as a treatment or prophylaxis of a wide variety of disorders associated with inflammatory states and / or with a lack of or need for nitric oxide (NO), such as inflammatory conditions, pain, free radical associated disorders, cardiovascular diseases, autoimmune disorders, pathological platelet aggregation, pathological vasoconstriction, vascular effects of diabetes, stroke, atherosclerosis, hypertension, abnormal vasospasm, and restenosis after angioplasty.

The invention provides a preparation method of avenanthramide and a derivative thereof. The avenanthramide and the derivative thereof are synthesized and obtained by mainly utilizing an organic acid and aminobenzoic acid as major reactants. The method is high in yield, few in by-products and applicable to the industrialized production of the avenanthramide and the derivative thereof. The avenanthramide has multiple bioactivities of anti-oxidation, anti-anaphylaxis, anti-proliferation and itching relief, meanwhile, also has certain effects of treating coronary disease and colonic cancer, and is often used in products of a emulsion skincare article, an after-sun repairing article, a rhinitis spray, a skin itching relieving infantile product, an externally used cream for treating dermatitis and the like.

The invention provides fermentation oat functional food with function of preventing fatty liver. The functional food is prepared by taking oat as a main raw material and performing cleaning, immersing, sterilization, fermentation, extraction, concentrating, drying, blending, sterilization, granulating, tabletting and packaging. The functional food is rich in polyphenol substances and avenanthramides, can be prepared into capsules, tablets, granular, pulvis, oral liquids or beverages, and has substantial efficacy of preventing fatty liver.

Topical sanitizers including alcohol-based gels, alcohol-based foams, alcohol-free foams, liquid soaps, alcohol-based wipes, and alcohol-based sprays include avenanthramides, which is an active component of oats that is beneficial to the skin. The concentration of avenanthramides can be substantially less when considering the use profile of the person using the sanitizers. Many healthcare workers sanitize their hands dozens of times a day. An effective dose of avenanthramides can be delivered to the skin even when the concentration in avenanthramides is relatively low due to the repeated application of the sanitizers during the day. In addition, a lower concentration of avenanthramides may be used to maintain healthy skin compared to a higher concentration that may be used to repair damaged skin. Minimum concentrations of avenanthramides in one or more topical sanitizers can be determined according to the use profile and the target amount of avenanthramides to deliver via the topical sanitizers.

Methods and compositions for treating or preventing a skin condition, an inflammation, an irritation or an allergy associated with an ectoparasitic infection or infestation on an animal. The methods involve applying to the skin of the animal a pharmaceutical composition that contains a therapeutically effective amount of one or more than one avenanthramide, an optional ecto and / or endo-parasiticidal agent, and a pharmaceutically acceptable diluent or carrier.

The invention features a composition and methods for treating inflammation of skin, where the composition contains hydrocortisone and an avenanthramide.

The invention relates to an avenanthramide extract as well as an extraction method and application thereof. The extraction method of the avenanthramide extract comprises the following steps of pretreating oat, performing oat germination, performing treatment on germinated oat, performing ultrasonic extraction, performing purification and the like. Avenanthramide is enriched through germination promoted with cinnamic acid, the effect is notable, the avenanthramide extract in which the content of the avenanthramide is 6.7-13.3% can be obtained, a useful way is provided for efficient enrichment of a natural antioxidant, the avenanthramide has favorable oxidation-resisting effect in edible oil, an advisable antioxidant source is increased for the edible oil industry and economic benefits are considerable.

Topical skin care composition for day use containing a combination of stabilized antioxidants, oat derived avenanthramide and biofunctional peptides and other optional ingredients for topical application for the treatment and prevention of skin damage due to environmental factors.

Exemplary embodiments provide oat fractions, and methods of producing the oat fractions, of the species Avena Sativa that has a concentration of total Avenanthramides that is from about 2 to about 25 wt. %, and up to about 30 wt. % or more, higher than the concentration before treatment with infrared energy. The higher concentration is achieved without treatment with enzymes or exposure to fungal agents to increase the concentration of total Avenanthramides. Instead, the enhanced concentration of Avenanthramides is achieved through exposure to infrared energy for a selected period of time.

Topical sanitizers including alcohol-based gels, alcohol-based foams, alcohol-free foams, liquid soaps, alcohol-based wipes, and alcohol-based sprays include avenanthramides, which is an active component of oats that is beneficial to the skin. The concentration of avenanthramides can be substantially less when considering the use profile of the person using the sanitizers. Many healthcare workers sanitize their hands dozens of times a day. An effective dose of avenanthramides can be delivered to the skin even when the concentration in avenanthramides is relatively low due to the repeated application of the sanitizers during the day. In addition, a lower concentration of avenanthramides may be used to maintain healthy skin compared to a higher concentration that may be used to repair damaged skin. Minimum concentrations of avenanthramides in one or more topical sanitizers can be determined according to the use profile and the target amount of avenanthramides to deliver via the topical sanitizers.

The invention discloses antibacterial contraceptive maintenance gel for women, and a preparation method thereof, and relates to the technical field of family planning. The preparation method comprisesthe following steps: adding a propylene glycol solution of domiphen bromide, an angelica polysaccharide solution, a propylene glycol solution of oat avenanthramides, a lysozyme solution and purifiedwater into a gelatinous refined okra glue solution while stirring, mixing, regulating the pH value to 5.0, and standing until swelling and mixing to obtain the antibacterial contraceptive maintenancegel for women. The preparation method is simple, and the antibacterial contraceptive maintenance gel is convenient to use, has a good maintenance effect on cervix uteri and vaginal mucosa, and is beneficial to long-term normal-temperature storage.

The invention discloses a method for separating and analyzing avenanthramide D and dihydroavenanthramide D. High performance liquid chromatography is adopted, the chromatographic column is a chiral chromatographic column with cyclodextrin as a stationary phase, the mobile phase is composed of an organic phase and an aqueous phase according to a volume ratio of (25-30):(70-75), the organic phase ismethanol, ethanol, acetonitrile or tetrahydrofuran, the aqueous phase adopts water as a solvent and contains 0.1-1 V% of a buffer agent and 0.1-1 V% of a pH adjuster, the buffer agent is triethylamine phosphate, triethylamine acetate or triethylamine, and the pH adjuster is glacial acetic acid or phosphoric acid; and the automatic injection volume is 0.5 [mu]L, the flow rate of the mobile phase is 0.5-1.5 mL / min, the detection wavelength was 254 nm, and the column temperature is 30 DEG C. The invention provides the reliable method for accurately completing the analysis and separation of the avenanthramide D and its hydrogenation product dihydroavenanthramide D by selecting the appropriate stationary phase, the appropriate mobile phase and appropriate determination conditions.

Producing soluble oat flour with an increased level of avenanthramides by using enzymes to precondition whole oat flour prior to extrusion.

A composition and method for an avenanthramide-enriched, oat-based product having improved health effects. The oat-based product includes an avenanthramide ingredient having avenanthramides 2c:2p:2f in ratios comprising at least one of 1:1:1 or 1:2:2. More particularly, the avenanthramide ingredient may be derived synthetically or recovered from processing raw oats into constituent oat fractions.

Topical skin care composition for night use containing a combination of stabilized anti-oxidants, oat derived avenanthramides, retinol-like compounds and biofunctional peptides and other optional ingredients for topical application for the treatment and prevention of skin damage due to environmental factors.

The invention relates to antibacterial itching-relieving mopidick which is prepared from the following raw materials in parts by weight: 23.5-73.07 parts of a phase A component, 26.9 to 73.5 parts ofa phase B component, and 0.03 to 3 parts of a phase C component; wherein the phase A component is prepared from water and EDTA-2Na; the B phase component is prepared from SP115C, propylene glycol, menthol, ethanol, borneol, a chamomile extracting solution, a malvasylvestris flower extracting solution, a radix paeoniae alba extracting solution, a honeysuckle flower extracting solution, a taraxacumofficinale extracting solution, a herba violae extracting solution and avenanthramide; the phase C component is prepared from capryloyl hydroxamic acid, ethylhexylglycerin and 1, 2-hexanediol. The invention also discloses a preparation method of antibacterial itching-relieving mopidick. The invention has the following advantages: a plurality of plant extracts are combined, such that good repairing, inflammation diminishing and anti-allergy effects are provided, and discomfort caused by pruritus after mosquito bite is relieved; various medicinal materials are matched with one another, so that the effects of repelling mosquitoes, relieving itching, diminishing inflammation and easing pain can be achieved; all the raw materials are fully utilized, the cost is reduced, the economic effect is improved, and popularization is facilitated.