The invention relates to antibacterial itching-relieving mopidick which is prepared from the following raw materials in parts by weight: 23.5-73.07 parts of a phase A component, 26.9 to 73.5 parts ofa phase B component, and 0.03 to 3 parts of a phase C component; wherein the phase A component is prepared from water and EDTA-2Na; the B phase component is prepared from SP115C, propylene glycol, menthol, ethanol, borneol, a chamomile extracting solution, a malvasylvestris flower extracting solution, a radix paeoniae alba extracting solution, a honeysuckle flower extracting solution, a taraxacumofficinale extracting solution, a herba violae extracting solution and avenanthramide; the phase C component is prepared from capryloyl hydroxamic acid, ethylhexylglycerin and 1, 2-hexanediol. The invention also discloses a preparation method of antibacterial itching-relieving mopidick. The invention has the following advantages: a plurality of plant extracts are combined, such that good repairing, inflammation diminishing and anti-allergy effects are provided, and discomfort caused by pruritus after mosquito bite is relieved; various medicinal materials are matched with one another, so that the effects of repelling mosquitoes, relieving itching, diminishing inflammation and easing pain can be achieved; all the raw materials are fully utilized, the cost is reduced, the economic effect is improved, and popularization is facilitated.