31 results about "Domiphen bromide" patented technology

Disclosed are oral care mouth rinse compositions formulated as stable oil-in-water emulsions comprising: (a) at least about 0.025% by weight of a quaternary ammonium antimicrobial agent, (b) at least about 0.05% by weight of an essentially water-insoluble volatile oil, and (c) at least about 50% by weight water, wherein the emulsion comprises oil droplets having an average mean particle size of about 350 nm or less. Examples of quaternary ammonium antimicrobial agent include cetylpyridinium chloride (CPC), tetradecylpyridinium chloride, N-tetradecyl-4-ethyl pyridinium chloride or domiphen bromide.

Disclosed are oral care compositions having reduced tooth staining propensity and comprising in a pharmaceutically acceptable carrier, a cationic antimicrobial agent and an anti-stain agent comprising one or more materials from each of at least two of the following chemical groups:Group 1. anionic agents,Group 2. aldehydes, ketones, and other reactive carbonyl compounds andGroup 3. nonionic ethoxylated surfactants.Examples of cationic antimicrobial agent include quaternary ammonium compounds such as cetylpyridinium chloride, cetyl pyridinium fluoride, tetradecylpyridinium chloride, N-tetradecyl-4-ethyl pyridinium chloride and domiphen bromide; chlorhexidine; and metal ion sources to supply metal ions such as stannous, zinc or copper.

Disclosed are oral care compositions effective to control mouth and breath malodour comprising in a pharmaceutically acceptable carrier, a combination of an antibacterial agent and a deodorizing or odor-neutralizing agent comprising a compound having the structure (I) wherein R1, R2, R3, and R5 may be identical or different, each representing H, a linear or branched C1-C6 alkyl or alkenyl, phenyl, -OH or -ORa; R4 is -OH, -ORa, phenyl, or a linear or branched C1-C6 alkyl or alkenyl; and Ra is phenyl or a linear or branched C1-C6 alkyl or alkenyl. The odor-neutralizing agent may further comprise one or more of an additional odor-neutralizing compound selected from a-damascenone, a-isomethylionone, a-ionone, ss-ionone, pulegone, piperitone, carvone, coenzyme Q10 or cinnamaldehyde. The antibacterial agent may comprise one or a mixture of a quaternary ammonium compound selected from cetylpyridinium chloride, tetradecylpyridinium chloride, N-tetradecyl-4-ethyl pyridinium chloride or domiphen bromide; metal ions such as stannous, zinc or copper; chlorhexidine; triclosan; triclosan monophosphate; or selected essential oils.

Disclosed are oral care compositions having reduced tooth staining propensity and comprising in a pharmaceutically acceptable carrier, a cationic antimicrobial agent and an anti-stain agent comprising one or more materials from each of at least two of the following chemical groups:Group 1. anionic agents,Group 2. aldehydes, ketones, and other reactive carbonyl compounds andGroup 3. nonionic ethoxylated surfactants.Examples of cationic antimicrobial agent include quaternary ammonium compounds such as cetylpyridinium chloride, cetyl pyridinium fluoride, tetradecylpyridinium chloride, N-tetradecyl-4-ethyl pyridinium chloride and domiphen bromide; chlorhexidine; and metal ion sources to supply metal ions such as stannous, zinc or copper.

The invention discloses a lotion against itching, wherein each 1000ml of the lotion comprises flavescent sophora root 50-70g, yellow corktree bark 50-70g, Chinese prickly ash 15-25g, borneol 0.5-2g, cnidium fruit 25-35g, dittany bark 25-35g, menthol 0.5-2g, domiphen bromide 0.5-2g. The preparing process of the lotion comprises steps of immersing cnidium fruit and pricklyash peel with 20 times by weight of water, distilling and collecting volatile oil, charging 5ml of Tween-80, grinding into slag, gathering distilled aqueous solution, merging raw materials and charging 12 times by weight of water for immersion, grilling and filtering, charging 10 times by weight of water into drug dross, grilling twice, filtering the decoction liquid, merging the filter liquor, filtering and merging the filter liquor with distilled aqueous solution, obtaining extract through decompression and concentration, charging ethanol to content of 60%, homogenizing, stewing, extracting supernatant fluid, reclaiming ethanol till no alcohol smell is present, and diluting to 1000ml with water.

The invention discloses paint for evaporative pattern steel castings, which is characterized in that aggregates of the paint are ferrochromium mineral powder, brown corundum powder and bauxite; additives are limestone powder, ferric oxide powder and cryolite powder; binders are silicasol, aluminum sulfate and a VAE (vinyl acetate-ethylene) copolymer emulsion; suspension cross-linking agents are calcium bentonite, attapulgite and cellulose sodium carboxymethyl; and assistants are sodium carbonate, OP-10 polyethylene alkyl alcohol ether, an organic silicon defoamer and domiphen bromide. The paint has the characteristics that the appropriate refractory aggregates are selected to regulate the high temperature permeability of the paint and effectively eliminate carbon generated from pyrolysis of polystyrene foam; the additives are added to eliminate carbon generated from the pyrolysis of the polystyrene foam in a casting process of the steel castings and effectively inhibit a carburization defect of the evaporative pattern steel castings; and the appropriate binders and suspension cross-linking agents are added to realize the due room temperature strength and high temperature strength of a coating.

The invention discloses a compound tincture for treating eczema. The compound tincture comprises a western medicine, a traditional Chinese medicine and a solvent, wherein the western medicine comprises the following active ingredients in parts by weight: 15-20 parts of indometacin and 0.5-1 part of domiphen bromide; the traditional Chinese medicine comprises the following active ingredients in parts by weight: 150-200 parts of lithospermum, 80-100 parts of honeysuckle, 120-150 parts of tuberculate speranskia herb, 80-100 parts of mulberry twig, 180-200 parts of monkshood, 70-90 parts of rhizoma atractylodis and 120-150 parts of radix clematidis; and the solvent is 1000 parts of alcohol at a mass concentration of 60-70%.The compound tincture is prepared by preparing materials, extracting the active ingredients of raw traditional Chinese medicines, and dissolving the active ingredients of the western medicine. The active ingredients and the solvent have a synergistic effect, and the compound tincture effectively clears away heat, carries out detoxification, sterilization and anti-inflammation, can relieve itching and pain in a short period, effectively cures the eczema, has no toxic or side effects, and is safe to administrate and simple to prepare.

Disclosed are oral care compositions effective to control mouth and breath malodour comprising in a pharmaceutically acceptable carrier, a combination of an antibacterial agent and a deodorizing or odor-neutralizing agent comprising a compound having the structurewherein R1, R2, R3, and R5 may be identical or different, each representing H, a linear or branched C1-C6 alkyl or alkenyl, phenyl, —OH or —ORa; R4 is —OH, —ORa, phenyl, or a linear or branched C1-C6 alkyl or alkenyl; and Ra is phenyl or a linear or branched C1-C6 alkyl or alkenyl. The odor-neutralizing agent may further comprise one or more of an additional odor-neutralizing compound selected from α-damascenone, α-isomethylionone, α-ionone, β-ionone, pulegone, piperitone, carvone, coenzyme Q10 or cinnamaldehyde.The antibacterial agent may comprise one or a mixture of a quaternary ammonium compound selected from cetylpyridinium chloride, tetradecylpyridinium chloride, N-tetradecyl-4-ethyl pyridinium chloride or domiphen bromide; metal ions such as stannous, zinc or copper; chlorhexidine; triclosan; triclosan monophosphate; or selected essential oils.

The invention relates to a reagent set for screening a 2-C-methyl-D-erythritol-4-phosphate cytidyltransferase (IspD) inhibitor. The reagent set comprises methylerythritol phosphate (MEP), cytidine triphosphate (CTP), IspD, enzyme reaction buffer solution, an ion reagent and a reagent for determining pyrophosphoric acid (PPi). The invention also relates to a method for screening the IspD inhibitor. By the method, domiphen bromide with anti-tuberculosis activity is screened from more than 3,000 compounds. The invention also relates to application of the domiphen bromide to the in-vivo / in-vitro inhibition of Mycobacterium tuberculosis and the preparation of anti-tuberculosis medicines.

The invention relates to clean-free skin and hand micro-emulsion disinfectant agent, and in particular relates to a clean-free skin and hand micro-emulsion disinfectant agent and a preparation method thereof. Under the situation of guaranteeing the effective sterilization, the concentration of ethanol is controlled to be less than 30 percent. Active sterilizing components of the disinfectant agent are chlorhexidine acetate and domiphen bromide, wherein the domiphen bromide has a surface active effect, the ethanol is used as an auxiliary surfactant and a propellant, and a skin and hand micro-emulsion disinfectant solution with the granularity of 1 to 200nm is prepared from injection oil, the surfactant and natural moistening skincare components. The skin and hand micro-emulsion disinfectant solution is practical, simple, high in safety, good in stability and low in thrilling, nano-grade particles form a protection film on a disinfected part, the sterilizing efficacy is high, the added natural moistening skincare component can deeply moisten and whiten the skin, the symptoms such as dry and dry itching caused by utilizing the disinfectant solution with high ethanol content for a long time can be remarkably improved, and an effect for protecting the skin and the hands can be realized.