1567results about How to "Long validity period" patented technology

The invention discloses a multiple reversible color change microcapsule anti-counterfeiting material and a preparation method and applications thereof. The preparation method comprises the following steps: dissolving at least one of temperature-sensitive material, humidity sensitive material, ultraviolet excited fluorescence material and infrared excited fluorescence material in high boiling point solvent containing UV resistant agent and antioxidant, then adding emulsifier and protective colloid to obtain emulsion solution, and adopting the in-situ polymerization method to obtain the anti-counterfeiting material with microcapsule structure. The microcapsule structure of the invention can isolate the air and the wall of the microcapsule can reduce the light transmission, thus improving the weather resistance and light resistance of the anti-counterfeiting material and prolonging the use validity of the product. The material is a microcapsule aqueous solution so that the material is completely applicable to the coating method of the currently existing water-based paint, removes apprehensions in areas of safety, health and environmental protection, thoroughly solves the defect of the complicated solvent-based (oily material) coating and processing method, satisfies the anti-counterfeiting demand and can be applied in papers, cloth and film materials in large.

The present invention is an aromatic-typed sustained releasing chlorine dioxide gelatum powder and the preparation method, which belongs to the technical field for gas disinfection. The present invention is applied to resolve the problem of stable releasing the chlorine dioxide disinfectant. The present invention comprises the material with the following weight, which comprises 8g to 24g chlorine dioxide precursor, 6g to 20g provocation agent with delayed release, 10g to 25g stabilizer, 10g to 24g colloid agent, 3g to 7g cross linking agent and 1g to 4g solid essence. Compared with the present technology, the present invention has the following advantages. Firstly, the preparation art is simple and the cost is cheap, also the application is effective and safe. Secondly, the chlorine dioxide gas can be released stably and the effective application period is long, which can reach 1month to 2 months. Thirdly, the product is stable with a long shelf life and a period of validity over 2 years. Fourthly, the air has a comfortable flavor after disinfection, which can realize double function of air disinfection and refreshing the air.

The invention discloses a procalcitonin (PCT) latex enhanced immunoturbidimetry detection kit and a preparation method thereof. The procalcitonin latex enhanced immunoturbidimetry detection kit comprises a reagent R1 and a reagent R2, wherein the reagent R1 mainly comprises a buffer solution 1, a stabilizing agent 1, a preservative 1, a coagulation increasing agent, a protective agent 1 and EDTA (Ethylene Diamine Tetraacetic Acid); the reagent R2 mainly comprises a buffer solution 2, a stabilizing agent 2, a preservative 2, a polystyrene latex microballon sphere, a PCT antibody and a protective agent 2; the particle size of the polystyrene latex microballon sphere in the reagent R2 is 100-600nm, the PCT antibody is one or more of a mouse anti-human PCT antibody, a goat anti-human procalcitonin antibody or a rabbit anti-human procalcitonin antibody, and the PCT antibody is connected with the polystyrene latex microballon sphere in a covalent coupling or physical absorption manner. Compared with the prior art, the PCT detection kit provided by the invention has the advantages of low preparation cost, good stability, high detection sensitivity and strong specificity, is easy to store, and is easily popularized in clinical.

The invention relates to the technical field of medicament delivery by a carrier, in particular to a lung targeting medicament carried proliposome used for injection and an application method thereof. Solid dispersion technology is adopted to obtain solution A by dissolving active medicament, phospholipid liposome, cholesterol liposome, surface active agent and acid type carrier in absolute ethyl alcohol or the mixed solvent of absolute ethyl alcohol and absolute ether; active carbon which is used for injection and has the volume being 0.1-1% of the volume of the solution A is added into the solution A; stirring, standing and filtering of the solution by a millipore filter are carried; therefore, aseptic solution B free of pyrogen is obtained; aseptic additives are added into the solution B under an aseptic condition; organic solvent is removed; and solid granular medicament carried proliposome or powdered medicament carried proliposome are obtained. The invention has the advantages that the preparation process is simple; the cost is low; the quality is controllable; the stability is good; and the invention is suitable for industrial production. The medicament carried proliposome prepared by effervescency dispersion technology has small and uniform particle diameter, the electric charge ranges from -10mv to -30mv, the proliposome can deliver over 90% medicament to a lung, and remarkable lung targeting effect is achieved, and thus being the best preparation delivering medicament by a carrier for treating lung diseases.

The invention discloses an L-polylactide filler for injection and a preparation method thereof. Active ingredients of the filler are L-polylactide particles, honeycomb HA and a synergist, the honeycomb HA is obtained by alcohol precipitation and drying of a water solution formed by mixing sodium hyaluronate high in molecular weight and sodium hyaluronate low in molecular weight in an alkaline condition, and the synergist is mannitol or a mixture of mannitol and aloe polysaccharide with a mass ratio of 1:0.05-0.12. The filler is simple to prepare, shorter in re-suspension time, long in validity period and more convenient to use.

The invention relates to the field of fine chemical engineering, in particular to an inner wall latex paint. The inner wall latex paint comprises bamboo charcoal powder, photocatalyst, acetate-acrylic emulsion and auxiliary agents acceptable in the coating. The inner wall latex paint provided by the invention releases low formaldehyde and volatile organic compounds (VOC), and the quality of the inner wall latex paint accords with national standards; proved by experiments, the inner wall latex paint can effectively inhibit bacteria, the bacteria inhibiting rate is over 99.99 percent, and the formaldehyde removal rate is 93.05 to 97.06 percent; and the VOC removal rate of the inner wall latex paint is 52.73 to 72.11 percent, the removal rate of benzene is 53.15 to 73.26 percent, and the inner wall latex paint can constantly and effectively remove the formaldehyde and other VOC in the air.

An immobilized bacterial fertilizer is prepared from the sodium alginate, activated carbon, bacteria, CaCl2 and H2O. Its advantages are high resistance to ambient condition, great number of living bacteria, long storage time, and durable acting.

The invention discloses antisepsis fresh keeping agent for the orange containing the tea saponin. The components have the weight percentages that tea saponin is of 0.01-80 percent, common orange antiseptic imazlil technical or prochloraz technical is of 0.5-80 percent, and the rest is assistant agent. The above components are mixed into emulsifiable concentrates, or wettable powder, or micro-emulsion, or suspending agent, or suspending emulsion, or emulsion in water, or soluble fluid. The invention lowers the fresh keeping cost as the medical effect is improved greatly, eliminates the toxicity of the chemical agent greatly, and has important significance for reducing the harm of the chemical agent on the environment and the human being, and for developing the vegetable extraction and the chemical agent mixture.

The invention relates to an inhalation spray of antivirus medicines. The inhalation spray comprises the following components in percentage by mass of 0%-30% of antivirus activity agents, 0%-30% of auxiliary agents, 0%-30% of taste masking agents and the balance solvents, wherein the content of the antivirus activity agents and the content of the auxiliary agents are not 0% at the same time. Compared with the prior art, the inhalation spray disclosed by the application has the purpose that during outbreak period of epidemic corona viruses and other viruses, people do not need to occupy medicalresources in short supply and only need to inhale the antivirus medicines into respiratory tracts, medicine administration is accurately targeted, and the objective of preventing virus infection and propagation can be achieved; in addition, through united medication of the antivirus activity agents and the auxiliary agents, besides, various medicines are inhaled into the respiratory tract of a patient, synergistic treatment effects are generated, the viruses are eliminated, and serious respiratory tract and infection and serious pulmonary infection caused by the viruses can be treated; and chloroquine type antivirus medicines and macrocyclic antibiotics are inhaled through spraying for united medication, and the dosage of the medicines can be notably reduced, so that side effects of prolonged QT intervals, Tdp and sudden cardiac death caused by the medicines can be reduced.

The present invention relates to a thick oil well water shut off technological process for thick oil well water shut off layer and improving exploitation effect. The process bases on 'deep move shallow shut off' principal, first selectively shutting off the big diameter for the oil layer by degradable organic shut off additives, then sealing the opening by high temperature resistant inorganic shut off additives, and realizing selective water shut off by pressure control and degradation of organic matter. The water shut off process is reasonable in design, reliable in criterion, and has the characteristic of small construction risk, high success rate and long validity period compared with other thick oil well water shut off processes, and provides a new effective process for solving the water shut off problem for thick oil especially middle thick oil well.

The invention discloses long-circulating solid lipid docetaxel nanoparticles and a preparation method thereof. The long-circulating solid lipid docetaxel nanoparticles comprise the following materialsin therapeutic effective dose: docetaxel, lipid materials, long-circulating auxiliary materials and an emulsifier. The long-circulating solid lipid docetaxel nanoparticles have small particle size, high encapsulation rate and good stability, and not only improve the solubility and the stability of the docetaxel, reduce the toxicity of the docetaxel, but also prolong the circulating time of a medicament in blood, and improve the therapeutic index of the medicament, so that the preparation has the characteristics of low toxicity, low allergy, high efficiency and targeting in clinical application.

The invention relates to the technical field of computers, and provides a login verification method and device based on stateless management, a storage medium and a server. The login verification method comprises the steps of obtaining a login request sent by a client, wherein the login request comprises a user name, a password and a source IP address; Verifying the user name and the password, generating a token if the verification is passed, and returning the token to the client; In the process of interacting with the client, if a data access request sent by the client is received, obtaininga source IP address of the data access request; And if the source IP address of the data access request is the same as the source IP address of the login request, prolonging the validity period of thetoken according to a preset rule. Through the arrangement, the problem of token expiration failure can be avoided, and the operation experience of a user on a client is effectively improved.

The invention relates to a compound microbial fertilizer and a preparation method thereof. The compound microbial fertilizer is characterized by being prepared from the following materials in percentage by weight: 40.0-50.0 % of rape seed cakes, 10.0-20.0% of crops straws, 1.5-3.0% of mycothallus, 0.5-1.0% of bacterium thallus and 35.0-40.0% of water. By using the solid fermentation method twice, the invention organically combines the fungi (Trichoderma harzianum and Aspergillus aculeatus for biological control effect) and the bacteria (Bacillus subtillis and Bacillus megatherium for growth-promoting effect), and realizes a simple preparation method. The compound microbial fertilizer has the advantages of environmental condition resistance, high count of active viable bacteria, less influence by the environment after application, slow release of thallus and long-term effective colonization at rhizosphere of plants, promotes plant growth and simultaneously has a certain biological control effect on soil-borne diseases.

The invention relates to an oxiracetam freeze-drying preparation for injection and a preparation method thereof, belonging to the technical field of medicines. The freeze-drying preparation is a crystal form compound formed by oxiracetam, D-sorbitol and mannitol in a weight ratio of 1: (0.2-0.25): (0.05-0.1). The oxiracetam freeze-drying preparation has the beneficial effects that the production cycle is shortened by about 20 hours, the rate of finished products is increased by above 99%, the phenomena such as the upward shifting and the eruption of the product are avoided, medicine molecules are constrained in crystal lattices, the water content is extremely low and can be controlled below 0.1%, the preparation is difficult to degrade and has relatively good stability, the period of validity is up to 36 months, the impurity content is greatly reduced, the single maximum impurity is less than 0.1%, and the total impurities are less than 0.5%; no organic solvents are involved in the production process, the energy consumption and the cost are substantially reduced, and the technology has environmentally-friendly effect and is suitable for large-scale industrialization production. Compared with the prior art, the oxiracetam freeze-drying preparation provided by the invention has obviously improved curative effect and is suitable for clinical application.

The invention discloses edaravone injection and a preparation method thereof. The injection contains edaravone serving as an active material, sodium pyrosulfite serving as antioxygen and propylene glycol serving as cosolvent. In the invention, in an edaravone injection production process, the sodium pyrosulfite antioxygen is added and high-purity nitrogen is charged into an ampoule bottle before and after liquid medicine canning and sealing to ensure the residual oxygen in the air above the liquid medicine in the ampoule bottle is less than 3 percent, so the edaravone is kept in a low-oxygen environment all the time. In the invention, the stability of the edaravone injection is improved, the period of validity of the edaravone injection is prolonged, and the safety and effectiveness of the edaravone injection in clinical use are ensured.

The invention provides a method for preserving the activity of a human cell membrane blood group antigen, which comprises the steps of: preparing an erythrocyte membrane blood group antigen extract, and then coating the prepared erythrocyte membrane blood group antigen on a solid microsphere so as to replace a fresh erythrocyte to be used for detecting a blood group antibody in a sample.

The invention belongs to fields of a method for refining and purifying compounds and products thereof, and particularly relates to a method for refining and purifying an ambroxol hydrochloride Chinese herbal medicine, a product thereof and the field of application. The method for refining the injection-level ambroxol hydrochloride is characterized by comprising the following steps of: adding 70.2to 88 volume percent of aqueous solution of ethanol (g/ml) into an ambroxol hydrochloride raw material (g) of which the purity is over 99.0 percent in a ratio of 1:(5.5-9.2); heating, and distilling until the ambroxol hydrochloride raw material is dissolved fully; stopping heating, cooling and crystallizing to separate ambroxol hydrochloride out; and filtering the solvent to obtain crystals, and drying to obtain the injection-level ambroxol hydrochloride. In the injection-level ambroxol hydrochloride raw material, an impurity B is less than or equal to 0.03 percent, an impurity E less than orequal to 0.002 percent, and total impurities except for the impurities B and E are less than or equal to 0.03 percent; and the purity is over 99.9 percent.

The invention relates to an algal oil DHA (Docosahexaenoic Acid) microcapsule, which consists of algal oil DHA, an antioxidant and a shell material. The antioxidant is prepared from VC (Vitamin C) palmitate, lecithin, carnosic acid, VE (Vitamin E) grease and citric acid based on the mass ratio of (40-60):(25-35):(5-10):(3-7):1 sequentially, and the dose of the antioxidant is 0.6-1.2% of the mass of the algal oil DHA; the shell material is prepared from modified starch, Arabic gum, cane sugar, maltose and vitamin C-sodium based on the mass ratio of (10-30):(5-10):(1-5):(1-3):1 sequentially, and the dose of the shell material is 60-70% of the mass of the algal oil DHA. The invention further discloses a preparation method of the algal oil DHA. According to the invention, the oxidation of the algal oil DHA is effectively slowed down, odor smell is covered, the stability of products is increased and the effect duration is prolonged.

The present invention discloses one kind of small volume vincamine injection and its preparation process. The small volume vincamine injection consists of vincamine as main medicine component 3-20 weight portions and supplementary material including co-solvent 0.1-1 weight portions, antioxidant 0.5-10 weight portions, physical stabilizer 50-100 weight portions, and blood stimulation regulator 0.5-10 weight portions. It has high stability, long validity period, high bioavailability, capacity of being used directly and other advantages.

The present invention discloses oil-in-oil nonaqueous microemulsion used as medicine carrier and its medicine preparation. The oil-in-oil nonaqueous microemulsion consists of oil phase I, oil phase II, surfactant and co-surfactant, and can dissolve water insoluble medicines to prepare microemulsion. The nonaqueous microemulsion has the advantages of no hydrolysis and long effective period, slow or controlled release of medicine, nanometer level dispersion of water insoluble medicine and obviously raised bioavailability. For example, the present invention can obtain bioavailability of puerarin microemulsion and puerarin sol as high as 40.41 % and 52.68 % separately.

The invention discloses a mechanical plug pipe column for multi-point discharge of a cased hole completion multi-section fractured horizontal well and a water plugging method. The water plugging pipe column comprises a pipe plug and a Y445-type releasing packer, wherein at least three Y441-type packers are arranged between the pipe plug and the Y445-type releasing packer at intervals; sealed oil layer packing sections and water outlet layer packing sections are formed between two adjacent Y441-type packers and the inner wall of a horizontal well sleeve; a security joint and a control switch are orderly connected between the two Y441-type packers on each oil layer packing section through oil pipes in series; the security joint is serially connected between the two Y441-type packers on each water outlet layer packing section through the oil pipe; and the oil layer packing sections and the water outlet layer packing sections are connected in series through the oil pipes. According to the mechanical plug pipe column for multi-point discharge of the cased hole completion multi-section fractured horizontal well and the water plugging method, a plurality of Y441-type packers are adopted to be in multi-stage combination with the control switch, so that effective plugging of multi-point discharge of the multi-section fractured horizontal well or any point discharge is achieved; effective production of a major reservoir section is achieved, and the effects of controlling water and increasing oil are achieved.