6 results about "Azacitidine" patented technology

The invention relates to the field of anti-tumor drugs, and discloses an anti-diffuse large B-cell lymphoma pharmaceutical composition, a preparation method and application thereof, the composition comprises azacitidine and Sanilisoma, the composition can improve the accumulation amount of VDUP1 protein in a cell nucleus through the combination of the methylation effect of DNMT3b on VDUP1 protein and the inhibition of XPO1 activity by Sanilisoma, and the anti-diffuse large B-cell lymphoma pharmaceutical composition can be used for preparing anti-diffuse large B-cell lymphoma. The chemotherapy effect is remarkably improved, the sensitivity of the DLBCL to the Sanisole is remarkably improved, and particularly, the pharmaceutical composition has a remarkable curative effect on R / R DLBCL patients.

The present disclosure relates generally to pharmaceutical dosage forms comprising azacitidine and chidaridine.

Methods of treating patients diagnosed with cancer harboring an IDH-1 mutation are provided, including the therapeutic administration of a certain inhibitor of a mutant IDH-1 as a single agent, or in combination with azacitidine (AZA).

The presented invention relates to Azacitidine (compound of formula (1)) particles characterized by bimodal particle size distribution, process for preparation thereof and composition comprising them.

The present disclosure relates generally to pharmaceutical dosage forms comprising azacitidine and cedazuridine.

The application relates to the field of medicine synthesis, in particular to a refining method of azacitidine. Crude azacitidine is added into a refining solvent to be stirred and dissolved, a crystallization solvent is added dropwise to be stirred, after crystals are separated out, temperature is reduced to be stirred to separate out crystals, and then filtration is carried out; the filter cake is washed with the crystallization solvent, and high-purity single crystal azacitidine is obtained; the refining solvents used in the application are low-toxicity solvents, the operation is simple and safe, and the problem of excessive residue is avoided; the crystallization solvents are low-boiling-point solvents, which are beneficial to recycling and utilization of the crystallization solvents and cost saving. Finally, single crystal products are obtained, the problem caused by different crystal types is avoided, the yield is improved, the operation is simplified, and the method is suitable for industrial production.