52 results about "Original research" patented technology

The invention belongs to the technical field of medicine, relates to a preparation method of cephalosporin, and more specifically relates to a preparation method of a stable cefuroxime sodium. According to the invention, a process control technique and a multiscale simulation technology are utilized to conduct on-line crystallization control of cefuroxime sodium, so as to obtain a cefuroxime sodium product with stable quality and crystal form, and moderate particles. The quality and especially the stability of the product are improved greatly, and product quality achieves a same level as that of ''Xilixin'' from an original researching factory.

The invention discloses a metronidazole tablet. The metronidazole tablet comprises a plain tablet and a film coating, wherein the used plain tablet comprises the following raw materials in parts by weight: 50 to 60 percent of metronidazole, 20 to 50 percent of a filling agent, 2 to 20 percent of an adhesive and 0.1 to 0.4 percent of a lubricant; the used film coating comprises the following raw materials in percent by weight: 83 to 84 percent of hydroxypropyl methylcellulose and 16 to 17 percent of polyethylene glycol. Through the preparation method of the preparation, a wet granulation process is adopted, povidone K30 or corn starch serves as an adhesive, corn serves as starch, calcium hydrophosphate serves as the filling agent, magnesium stearate serves as the lubricant, and the hydroxypropyl methylcellulose serves as a coating material, so that the hardness, friability and in-vitro release of the preparation are improved, the metronidazole tablet has high hardness, the tablet is smooth and has high friability, the tolerance of the coating process is high, the prepared metronidazole tablet has in-vitro release consistent with that of metronidazole Spanish original research, the rapid release condition is met, the metronidazole tablet has equal curative effect, and the whole preparation method is simple to operate, controllable in quality and suitable for industrialized production.

The invention provides a public transport data based system and a public transport data based method for calculating an area popularity gathering index. The method includes the following steps: S1, collecting public transport data; S2, dividing an original area and establishing a buffering area according to the original area; S3, acquiring movement information of people going in and out of the original area from the public transport data to acquire an original popularity gathering index; S4, acquiring movement information of the people going in and out of the buffering area of the original area from the public transport data to acquire a popularity gathering index of the buffering area; S5, building a popularity guiding model according to an accumulated value of the original popularity gathering index and the popularity gathering index of the buffering area; S6, correcting the original popularity gathering index according to the popularity guiding model to acquire a final popularity gathering index. By the system and the method, the popularity gathering index of any specific area can be measured accurately without other measuring equipment; compared with existing measuring methods depending on video or infrared instruments, the method has the advantages of being more economical in cost, simple, convenient and quick.

The invention discloses a preparation method of an irbesartan capsule and application in the evaluation of generic drug consistency. After Irbesartan is mixed with various auxiliary materials to prepare a soft material, granulation is performed through an extruding granulation method, granules are evenly mixed with a lubricant after drying, and the capsule is filled. The irbesartan capsule produced by adopting the preparation process is consistent to an original research product (product name: irbesartan tablets; trade name: Avapro; specification: 0.15 g; production manufacturer: Sanofi Winthrop Industrie) on the aspect of multiple in-vitro dissolution curves, related substances have no obvious change in the test acceleration and long-term test stability investigation process and are biologically equivalent to the original research product.

The invention relates to a norfloxacin composition and belongs to the technical field of pharmacy. According to the technical scheme provided by the invention, the norfloxacin composition is preparedfrom norfloxacin, lactose, cross-linked sodium carboxymethyl cellulose and other pharmaceutically acceptable auxiliary materials. The pharmaceutically acceptable auxiliary materials comprise a fillingagent and a lubricant and the granularity of the norfloxacin is distributed in a range that D90 is greater than or equal to 200mu m and less than or equal to 300mu m. The invention provides the stable norfloxacin composition with a dissolution behavior which is the same as that of an original research.

The invention relates to the technical field of oxygen solubility control, particularly to a method for controlling the oxygen solubility of original beer in cold-chain logistics process. Fully-enclosed bear injection is achieved through controlling the process from ex-factory transport of the original beer to injection of the original beer into bear terminals; the oxygen content of the original beer is monitored through arranging an oxygen solubility detection feedback system; the oxygen solubility is reduced in the form of injecting carbon dioxide when the oxygen solubility is out of limit through arranging an oxygen solubility regulating system; if detecting beer deterioration, disinfectants are injected into a pipeline through connecting a cleaning pipeline so as to ensure the oxygen solubility of the original beer in the cold-chain logistics process. The method provided by the invention is rational in design and original in conception. A full-sealed bear injection docking device is designed to ensure that the internal and external environments of the device are in the sealed state all the time and exempted from pollution by outside environment. In the device, the oxygen concentration in the pipeline and a target container can be adjusted automatically through an oxygen solubility control system so as to meet the requirements of safety, refreshment and bear injection.

In order to solve the problem that through adoption of an existing allocation method, limited resources cannot be sufficiently utilized and high system throughput and energy efficiency cannot be acquired, the invention discloses a cognition-based original resource and detected hole resource joint allocation method and belongs to the technical field of information and communication. The method comprises the steps that the user minimum data transmission rate R<min>, a user available power upper limit P<max><T>, a spectrum detection threshold I1 and a sub-channel interference preset thresholdI2 are set; a BS / AP (Base Station / Access point) node in a multi-attribute heterogeneous system allocates original sub-channels to each user and detects spectrum hole sub-channels in the multi-attribute heterogeneous system through utilization of the spectrum detection threshold I1and the sub-channel interference preset threshold I2, and the BS / AP node allocates the detected spectrum hole sub-channels to each user; and when allocation is carried out, the fact that R<m> is greater than or equal to the R<min> and P<m> is smaller than or equal to P<max><T> is taken as a limitation condition, and moreover, through utilization of a Lagrange duality method, an optimum user original sub-channel allocation result and an optimum spectrum hole sub-channel allocation result are acquired,wherein the R<m> indicates a data transmission total rate of a user m, and the P<m> indicates the total power consumed by the user m.

The invention discloses a traceability risk assessment method for aflatoxin in oil crops in the technical field of food safety. The method comprises the following main steps of: S1: carrying out original research on grain and oil crops; S2: carrying out sample pretreatment; S3: carrying out sample detection and data acquisition; S4: carrying out data analysis and result output; S5: establishing aflatoxin exposure assessment indicators; S6: establishing an aflatoxin exposure assessment model; and S7: controlling the product storage environment and storage time of plant edible oil. According tothe method, a liquid quality-mass spectrometry technique is used to determine the content of aflatoxin; the sample pretreatment process is simplified, so that the detection efficiency is improved; thecontent of aflatoxin daily ingested by human body is fitted to establish the aflatoxin exposure assessment model; and the content of aflatoxin is controlled from the planting, processing and productstorage links of oil crops, thereby reducing the daily ingestion of the human body and improving the safety of grain and oil crops.

The invention provides azacitidine lyophilized powder for injection. The azacitidine lyophilized powder is prepared from, by weight, 2-8 parts of azacitidine, 2-8 parts of mannitol, 100-300 parts of acetonitrile and 684-896 parts of water. The invention further provides a preparation method of the azacitidine lyophilized powder for injection. The preparation method comprises the steps that part ofthe water for injection is added into a liquid preparation tank; 100-300 parts by weight of acetonitrile is added, and stirring is conducted until the mixture is clear; 2-8 parts by weight of mannitol is added, stirring is conducted until the mixture is completely dissolved, and the temperature is lowered to be 0-4 DEG C; 2-8 parts by weight of a pre-micronized raw azacitidine material is weighed, washed with part of the remaining water for injection and then added into the liquid preparation tank, intensive stirring is conducted until the mixture is dissolved, and the water for injection isadded to reach the constant volume of 1000 parts; after sterile filtration, filling and freeze-drying, the preparation product is obtained. The particle size of the product and the total impurity level of the product can be effectively controlled, the stripping curve and other bioequivalence indexes of the product are equivalent to those of an original research product, and the total impurity level is lower than that of the original research product.

The invention discloses a preparation method of cefradine with an original research quality on the basis of KR840002043 (B1) and US4235900 (A). The preparation method comprises steps as follows: (1) dihydrophenylglycine chloride hydrochloride is added to a solvent, the mixture is cooled, protected 7-ADCA is added to the mixture, and the mixture is subjected to a condensation reaction after being mixed; (2) water and hydrochloric acid are added after the reaction ends, the mixture is subjected to a hydrolysis reaction, an organic phase layer is left to stand for use, a water layer is subjected to vacuum distillation, and non-distillate is retained; (3) the non-distillate is crystallized and filtered, filtrate is left to stand for use, a filter cake is washed and dried, and cefradine is obtained; (4) the organic phase layer and the filtrate are combined, and cefradine is recycled and extracted. The invention further discloses composition of cefradine with the original research quality. The prepared cefradine and the cefradine composition have the original research quality, the preparation method is simple, the reaction conditions of the whole procedure are relatively mild, the cost of raw materials is low, little pollution is caused, and the prepared cefradine composition has stable and high quality.