49 results about "Metronidazole" patented technology

The invention relates to application of an SLC30A9 inhibitor in preparation of an anti-tumor medicine, and belongs to the technical field of biological medicines. The invention provides an application of an SLC30A9 inhibitor in preparation of an anti-tumor drug. The expression of SLC30A9 is down-regulated to activate a cGAS-STING-NF-kappa B pathway, so that apoptosis of osteosarcoma cells is promoted, killing of the osteosarcoma cells by MTX is enhanced, and sensitivity of the osteosarcoma cells to MTX chemotherapy is recovered. Through combined application of SLC30A9 knock-down, a cGAS-STNG-NF-kappa B pathway agonist and MTX for chemotherapy, the killing effect of MTX on osteosarcoma cells can be remarkably enhanced, tumor cell proliferation is inhibited, and the treatment effect is improved. The core effect of the SLC30A9 in an osteosarcoma chemotherapy drug resistance mechanism is defined, and a theoretical basis and a technical support are provided for subsequent development of targeted drugs aiming at a cGAS-STNG-NF-kappa B pathway.

This invention relates to a method for preparing a nanozyme detection reagent for carbofuran residues in apples, belonging to the field of pesticide residue and food safety technology. Specific steps: (1) Prepare mesoporous polydopamine powder using polyoxyethylene-polyoxypropylene-polyoxyethylene triblock copolymer, dopamine hydrochloride, etc.; (2) Prepare a copper-manganese bimetallic carbon dot solution using citric acid, copper chloride, manganese chloride, and ethylenediamine; (3) Prepare the nanozyme detection reagent using the mesoporous polydopamine solution and the copper-manganese bimetallic carbon dot solution. Mesoporous polydopamine has a large specific surface area, providing numerous sites for carbon dot loading and effectively adsorbing carbofuran molecules. The copper-manganese bimetallic carbon dots give the nanozyme detection reagent good enzyme-like activity and generate pesticide concentration-dependent colorimetric and photothermal signals. This invention achieves mutual verification of dual-mode output signals, significantly improving detection reliability; and completes detection within 1.5 h.

The invention relates to an application of a phosphorus vacancy mediated transition metal-based cathode material in electro-Fenton-like selective degradation of metronidazole antibiotics. The phosphorus vacancy-mediated transition metal-based cathode material is NiCoP-Vp, foamed nickel is used as a substrate, and a phosphorus vacancy-containing NiCoP catalyst is loaded on the surface of the substrate; the NiCoP catalyst containing the phosphorus vacancy is in a nanoneedle shape, and a large number of holes are formed in the surface of the NiCoP catalyst. The transition metal-based catalyst containing the phosphorus vacancy has higher electron transmission efficiency and relatively larger electrochemical active area, more active sites can be exposed, and 100% removal of metronidazole can be selectively realized. The fully exposed active sites provide more sites for the adsorption and activation of H2O2 and O2, the improved charge transfer can accelerate the redox cycle of transition metals, the two can cooperatively regulate and control to generate superoxide free radicals O2 <.-> and high-valence metal oxygen, and finally the selective efficient degradation of metronidazole antibiotics is realized.

The invention discloses a medicine for inhibiting helicobacter pylori infection, the medicine is oridonin, and the structural formula of the medicine is as shown in formula 1. In-vitro experiments show that the oridonin has a remarkable antibacterial effect on helicobacter pylori strains SS1, ATCC700392 and ICDC11101, and can remarkably reduce the urease activity of the helicobacter pylori, inhibit the formation of a biological membrane, destroy the growth of thalli and reduce the adhesion effect of the helicobacter pylori on gastric epithelial cells, and in addition, the oridonin and antibiotics are combined for use, so that the effect of preventing and treating the gastric epithelial cells can be achieved. The compound has a synergistic antibacterial effect with metronidazole and clarithromycin, has the effect of reducing the dosage of antibiotics in clinical application, and has potential application value for improving the current drug resistance situation of the antibiotics.

The invention discloses a bionic bone scaffold composite material prepared through combination of electrostatic spinning and 3D printing and a preparation method of the bionic bone scaffold composite material, and relates to the technical field of bionic bone scaffold composite materials. A bionic bone scaffold composite material prepared by combination of electrostatic spinning and 3D printing is characterized by comprising 80 to 100 parts of a biodegradable high-molecular polymer, 5 to 30 parts of a bioactive inorganic ceramic material, 200 to 500 parts of a solvent, 0.01 to 5 parts of a bioactive factor, 0.1 to 0.5 part of a bacteriostatic active compound and 0.01 to 5 parts of naringin. According to the invention, the metronidazole derivative is used for providing antibacterial ability, and is matched with naringin to realize anti-inflammatory and osteogenesis-promoting synergistic effect, so that the problem of drug resistance or non-uniform drug release of the traditional antibacterial means is avoided, the induction effect of the stent on bone regeneration is enhanced, and the infection risk in the repair process is reduced.

The invention discloses nanogel for activating metronidazole to co-treat non-anaerobic bacteria infection through starvation therapy. The nanogel takes composite nano hydrogel which is formed by compounding sodium alginate SA, a natural polyphenol compound and high-valence metal ions and has a three-dimensional network structure as a main carrier; glucose oxidase GOx and anaerobic bacteria antibiotics required by starvation therapy are loaded in composite nanogel, meanwhile, natural polyphenol and high-valence metal ions in the composite nanogel can be self-assembled to form a metal-polyphenol network structure MPNs, and the nanogel loaded with GOx and MNZ is packaged to prepare the composite nanogel. A new cocktail therapy is constructed, a new thought is provided for research and development of antibacterial treatment drugs, and great scientific research significance and clinical application value are achieved for collaborative treatment of tolerant bacteria.

The invention discloses application of copper sulfate in inhibition of trichomonad activity, in-vitro tests prove that copper sulfate can induce oxidative stress of trichomonad, interfere with sulfur-containing amino acid metabolism, destroy the structure of trichomonad cells and reduce the active oxygen content and hydrogenase membrane potential of trichomonad bodies, and the minimum inhibition concentration of copper sulfate on trichomonad within 48 hours is 640 micrograms / mL. In-vivo tests prove that copper sulfate is added into drinking water according to the concentration of 500 mu g / mL, and is periodically fed once every 15 days and continuously 4 days each time, so that the number of trichomonad in the oral cavities of laying pigeons of silver-feather king pigeons and young pigeons of white-feather king pigeons can be remarkably reduced, and meanwhile, the quality of pigeon eggs is improved, and the immunity and intestinal microbial flora are improved; the application method provided by the invention is safe, efficient and low in cost, the addition concentration of copper sulfate is easy to control, no drug residue risk exists, and the composition can replace traditional antibiotics such as metronidazole to be used for preventing and treating trichomonad of pigeons, is suitable for a large-scale meat pigeon breeding scene and has a wide application prospect.

The invention relates to the technical field of wastewater treatment microorganisms, in particular to a detoxification synergistic treatment process for metronidazole-containing pharmaceutical wastewater, which comprises the following treatment steps: (1) metronidazole-containing pharmaceutical wastewater enters a dealdehyding tower in advance for dealdehyding treatment, and then enters a primary settling tank for settling to remove scum; (2) enabling the wastewater obtained in the step (1) to sequentially enter a hydrolysis acidification tank, a UASB anaerobic tank and a mid-sedimentation tank; (3) the wastewater is settled in the middle settling tank, enters an anoxic tank and an aerobic tank for biochemical treatment, is subjected to mud-water separation through a secondary settling tank, and is discharged; and (4) enabling the effluent of the secondary sedimentation tank to enter a deep treatment unit through a pipeline for treatment, then entering a decoloration tank for decoloration, and discharging. In order to improve the COD degradation efficiency of metronidazole-containing pharmaceutical wastewater in an anaerobic tank and stabilize the COD of the effluent, the invention provides a microbial agent which has strong adaptability to water quality and water quantity fluctuation and is stable in operation.

A topical formulation, comprising: an ointment base; and a mixture of active pharmaceutical ingredients (APIs) contained in the ointment base, the mixture of APIs consisting of: Metronidazole; Ivermectin; and Melaleuca alternifolia (tea tree) oil. The APIs are about 0.12%-6% w / w and the ointment base is about 94% to 99% w / w of the topical formulation. The formulation can further include enhancers for the APIs, such as, moisturizers and anti-oxidants. The formulation is configured as an anti-parasitic, anti-inflammatory and anti-microbial formulation.

A medicated eyelid cleansing composition comprising a medicated scrub composition and an eyelid cleansing composition. The medicated scrub composition has one or more antibacterial and anti-inflammatory agents, including azithromycin and diclofenac sodium or dexamethasone phosphate. The medicated scrub composition can further include a combination of metronidazole and ivermectin. The composition is optimized for physiological compatibility and can be combined with a suitable substrate for use as a medicated eyelid cleanser.

Disclosed is a bile acid-metronidazole conjugate or a stereoisomer thereof, or a salt thereof, or a solvate thereof, or a prodrug thereof, or a metabolite thereof. The bile acid-metronidazole conjugate is prepared using an esterification reaction of a bile acid compound with hydroxyl group on a metronidazole structure. The synthesis process is simple and easy for industrialization. The bile acid-metronidazole conjugate can effectively inhibit the growth of anaerobic bacteria, especially the growth of Clostridioides difficile and Helicobacter pylori, so that the bile acid-metronidazole conjugate has a significantly improved therapeutic effect in the treatment of infections caused by the anaerobic bacteria.

The invention discloses a metronidazole phospholipid composition as well as a preparation method and application thereof, and relates to the technical field of biological medicines, and the metronidazole phospholipid composition comprises metronidazole and phospholipid. The metronidazole phospholipid composition prepared by the invention improves the intracellular drug delivery efficiency under the condition of retaining the original chemical structure and biological activity of metronidazole, and a new method is provided for treatment of intracellular infection of anaerobic bacteria. The problem that existing metronidazole is poor in intracellular infection treatment effect is solved.

The invention relates to the technical field of wastewater treatment microorganisms, in particular to a complex microbial inoculant for metronidazole pharmaceutical wastewater as well as a preparation method and application thereof.The complex microbial inoculant comprises thalli and a protective agent, and the thalli are prepared from 16.3%-26.7% of anaerobic rope bacteria, 12.0%-20.5% of kristson bacteria, 13.0%-16.6% of Gracilinema bacteria, 2.4%-6.9% of kiwi bacteria, 2.2%-4.3% of co-edible bacillus, 1.1%-6.3% of candidate warm bacillus, 2.1%-3.7% of hot filament bacteria, 2.1%-3.1% of patella and 27.8%-38.7% of other bacteria. Aiming at the problem of difficulty in biodegradation in treatment of metronidazole pharmaceutical wastewater containing high-concentration sulfides in the prior art, the complex microbial inoculant system cooperates and cooperates with each other, and can adapt to stress of high-concentration sulfides in high-COD metronidazole pharmaceutical wastewater; the COD degradation capability is excellent, and the metabolic capability is strong.

The invention relates to the technical field of fluorescence sensing, in particular to a dysprosium (III) coordination polymer as well as a preparation method and application thereof. The dysprosium (III) coordination polymer is prepared through a one-pot solvothermal reaction, the dysprosium (III) coordination polymer has an expression of [Dy2 (bppc) 5 (gluu) 2 (H2O) 4] n, and the preparation method has the advantages of being simple in process, convenient to operate, high in yield, good in reproducibility and the like. The dysprosium (III) coordination polymer prepared by the invention has better fluorescence property, shows high selectivity and high sensitivity to antibiotics, and can be used for effectively detecting metronidazole through a fluorescence quenching phenomenon. Meanwhile, according to the high-security information encryption system based on the dynamic optical characteristics of the Dy-based luminescent material, information counterfeiting and copying are effectively eradicated through luminescent signals capable of being randomly combined and a real-time refreshed'one-time dynamic password 'mechanism of the high-security information encryption system.

The application discloses a compound medicament for treating trichomonas gallinae, a preparation method of the compound medicament and a medicine, and aims to provide a novel, rapid and safe treatment formula which can replace metronidazole in treating trichomonas gallinae disease. The compound medicament prepared by mixing the aqueous extract of Sophora flavescens and the copper-containing adjuvant can kill the trichomonas gallinae in the pigeon in a short time, and cannot cause drug resistance and drug residue problems, and the formula of the application is simpler and has a shorter medication time than other traditional Chinese medicine formulas.

The present invention relates to the field of reducing methane emissions from ruminants. In particular, the present invention relates to administering to a ruminant a combination of 3-nitrooxypropanol and / or a derivative thereof and metronidazole for reducing methane production resulting from digestive activities of said ruminant.

This invention discloses the application of *Gastrococcus xanthophylloides* in regulating intestinal bile acid metabolism disorders, including *Gastrococcus xanthophylloides* (… Ruminococcus flavefaciens The application of this invention in the preparation of compositions for regulating intestinal bile acid metabolism disorders, wherein the compositions promote the conversion of primary bile acids to secondary bile acids, wherein the primary bile acids include cholic acid and chenodeoxycholic acid, and the secondary bile acids include deoxycholic acid and lithocholic acid; wherein the intestinal bile acid metabolism disorders include metabolic disorders caused by antibiotics, wherein the antibiotics include one or more of moxifloxacin and metronidazole; wherein the compositions can be health products, pharmaceuticals, or feed; and wherein the active ingredient of the compositions includes xanthospirococcus flavus.

Described herein is a method of predicting whether a bacterial vaginosis (BV) patient will respond to metronidazole treatment. The method comprises detecting a presence or absence of at least one of the Gardnerella vaginalis (Gv) genes selected from the group consisting of aruH, Ami, Cluster 1311, comEA, crcB, group_2326, group_2343, group_2558, group_2577, ssb, truB, yfeA, ykoD, and YneA, or an mRNA product, a protein product, or a metabolite thereof, in a sample from the patient. Also described herein is a method of treating, ameliorating, and / or preventing BV in a subject, which comprises administering to the subject an effective amount of metronidazole or an effective amount of clindamycin based on a prediction of whether the subject responds well to metronidazole treatment.

The application discloses a preparation method of a rapid detection kit for metronidazole residue in rice, and belongs to the technical field of bio-agriculture. The method comprises the following steps: preparing a magnetic molecular imprinting enrichment agent, molybdenum-copper double-atom nitrogen-sulfur co-doped carbon dots, a hollow mesoporous polydopamine carrier and a colorimetric-photothermal dual-signal nanoscale enzyme reagent, and packaging the above reagents into a box together with acidolysis extraction liquid, substrate color developing liquid and standard comparison liquid. The kit can realize selective enrichment, matrix purification and colorimetric-photothermal dual-channel detection of metronidazole in rice samples, has the advantages of simple operation, rapid detection, strong anti-interference ability and high reliability of results, and is suitable for on-site rapid screening of metronidazole residues in paddy, brown rice and milled rice.

The invention belongs to the field of drug analysis and research, and particularly relates to a method for researching the interaction between cinnamyl amino porphyrin and metronidazole by adopting a micelle sensitization fluorescence quenching analysis method, and by taking the fluorescence quenching effect of metronidazole on a porphyrin compound which is a fluorescent probe molecule as well as the ratio of the reduction degree of fluorescence intensity to the concentration of the substance as an example, the detection of the interaction between cinnamyl amino porphyrin and metronidazole is realized. A novel fluorescence analysis method which is high in sensitivity, good in selectivity and simple and convenient to operate and can be used for measuring the content of a daily drug metronidazole is established; the novel fluorescence analysis method for measuring the content of metronidazole is not reported in literatures; the structure of the cinnamyl amino porphyrin (I) is shown in the specification.

The application discloses a combined medicine against helicobacter pylori, and aims to provide a combined medicine against helicobacter pylori, which has a significant inhibiting effect on a standard strain SS1 of helicobacter pylori, can effectively destroy a biofilm structure of the standard strain SS1 of helicobacter pylori, and has a synergistic bacteriostatic effect. The technical scheme is that an extract of fructus amomi essential oil is combined with antibiotics commonly used in clinical treatment of helicobacter pylori infection. Experiments show that the technology provided by the application has a synergistic effect with metronidazole, levofloxacin, clarithromycin and amoxicillin. The technology has an effect of reducing the dosage of the antibiotics used in clinical application, has potential application value for improving the drug resistance status of the antibiotics, and belongs to the technical field of medicines.

The application discloses a medicine composition for killing trichomonas vaginalis, and the active ingredients of the medicine composition are composed of fibraureus and metronidazole; the mass ratio of the fibraureus and the metronidazole is 1:1-8:1; in the process of killing the trichomonas vaginalis, the concentration of the fibraureus is 0.01-0.04 g / L, and the concentration of the metronidazole is 0.005-0.02 g / L. The medicine composition can effectively kill the trichomonas vaginalis, the fibraureus combined with the metronidazole can effectively reduce the medication time and the dosage of the metronidazole, can avoid the risk of premature delivery of pregnancy medication, and can reduce the health problems of breast-feeding infants during the medication period; the problems of adverse reactions and drug resistance of the metronidazole and other nitroimidazole drugs in treating trichomonas vaginalis disease are solved; the application provides a theoretical basis for treating drug-resistant trichomonas vaginalis vaginitis by combining traditional Chinese medicine with western medicine, and further expands the clinical application of the fibraureus.

The invention discloses a construction method and application of an Eriocheir sinensis gut-brain axis research model, according to the method, metronidazole, neomycin and vancomycin are added to commercial feed according to the mass ratio of 10: 10: 5 g / kg to prepare compound antibiotic feed, and the Eriocheir sinensis is continuously fed for 96 h. According to the method, a standardized research model capable of synchronously and controllably presenting the causal relation of'intestinal flora disturbance-nervous system response 'is constructed in crustacean for the first time. The model is short in construction period, high in stability and high in repeatability, and a key research tool is provided for deeply analyzing the enteric-cerebral axis interaction mechanism of the eriocheir sinensis and even crustacean, screening neural active substances and evaluating neurotoxicity of environmental stress.

The invention provides a preparation method of a seaweed active component for inhibiting helicobacter pylori, which comprises the following steps: cleaning seaweed, and drying in a drying oven at 60 DEG C until the weight is constant; seaweed and distilled water are prepared into a seaweed suspension according to the ratio of (0.5-1.5) g: (50-100) mL; adding 2-3% g / g glucose into the seaweed suspension, and performing pasteurization at 65 DEG C for 30 minutes; adding lactobacillus into the seaweed turbid liquid according to the volume ratio of 4-6% v / v, and fermenting at the constant temperature of 37 DEG C for 46-50 hours to obtain a seaweed fermentation mixed liquid; centrifuging the seaweed fermentation mixed solution to remove seaweed residues and thalli to obtain a seaweed fermentation product; and carrying out solvent distribution extraction on the seaweed fermentation product, taking an organic phase, carrying out rotary evaporation to remove the organic solvent, and washing with methanol to obtain the seaweed active component. The diameter of a helicobacter pylori inhibition zone of the seaweed active component reaches 1.8 cm, and compared with a positive control (5 mg / mL metronidazole), the bacteriostasis rate can reach 77.25%.

The present invention relates to a composition for preventing or treating periodontal disease and a dental composite antibiotic ointment composition. The composition for preventing or treating periodontal disease according to the present invention comprises minocycline and metronidazole as effective ingredients.

The invention discloses a construction method and application of an Eriocheir sinensis intestinal flora deletion model, the method comprises the following steps: feeding Eriocheir sinensis with a feed mixed with mixed antibiotics for 96 hours to obtain the Eriocheir sinensis intestinal flora deletion model; the mixed antibiotic is prepared from metronidazole, neomycin and vancomycin. A plate culture method verifies that the optimized core antibiotic concentration group can enable the clearance rate of intestinal content florae to reach 95% or above and the clearance rate of fecal florae to reach 90% or above. According to the method, the intestinal flora deletion model of the eriocheir sinensis is constructed for the first time, the method has the advantages of being high in removal efficiency, good in repeatability, small in stress and the like, the flora is restorable after drug administration is stopped, and a standardized experimental tool is provided for studying the intestinal-brain axis mechanism, physiological metabolism and healthy breeding of crustacean.

The application discloses a metronidazole co-crystal and a preparation method and application thereof, and a structure formula of the co-crystal is shown as formula I: the metronidazole co-crystal has a faster dissolution rate and a higher apparent solubility, improves a peak concentration thereof, and can reach a higher blood drug concentration in a short time, so that rapid control on infection symptoms is realized.

The invention provides a fosfomycin sodium composition and a preparation method thereof, and particularly relates to the field of medicines. Comprising freeze-dried powder prepared from fosfomycin sodium and metronidazole lipid microspheres, the mass of the freeze-dried powder containing fosfomycin sodium is 0.09-1.01 g, the mass of the metronidazole lipid microspheres is 145-155 mg, the mass of metronidazole contained in the metronidazole lipid microspheres is 50 mg, and the pH value of the freeze-dried powder dissolved in 5 ml of water at the temperature of 25-35 DEG C is 6.0-6.5. Different from traditional single-variety drug combination, metronidazole is lipid microspheres, so that the bioavailability of metronidazole can be improved; the medicine and fosfomycin sodium are jointly filled into the same penicillin bottle, so that clinical medication is facilitated.

The invention relates to the field of pharmaceutical preparations, in particular to a clindamycin metronidazole vaginal foaming agent and a preparation method thereof. The clindamycin and metronidazole vaginal foaming agent is prepared from the following components in parts by weight: 8 to 12 parts of clindamycin phosphate, 6 to 10 parts of metronidazole, 15 to 25 parts of alkyl glycoside, 50 to 70 parts of poloxamer, 100 to 150 parts of tetrafluoroethane, 4 to 28 parts of pH buffer agent, 50 to 60 parts of ethanol, 70 to 80 parts of propylene glycol and the balance of purified water, wherein the total part number is 1000. Through mutual cooperation of clindamycin phosphate and metronidazole, the growth of microorganisms is blocked through dual effects, the clindamycin phosphate and metronidazole are combined to cover a wider pathogen range, and especially the effect of inhibiting mixed anaerobic bacteria infection is better. In the formula, the alkyl glycoside and the poloxamer are matched for use, so that a foam liquid membrane can be stabilized, foaming can be accelerated, the foam defoaming time can be further prolonged, and the treatment effect of the clindamycin metronidazole vaginal foaming agent is guaranteed.

This invention provides an insecticide containing a pyrimidinone metronidazole compound and its application, belonging to the field of pesticide technology. The active ingredient of this insecticide comprises a pyrimidinone metronidazole compound as shown in Formula I; (I); where R... 1 It is 2-chlorothiazol-5-yl or 6-chloropyridin-3-yl, R 2 and R 3 It can be H, F, Cl, Me, or CN. This insecticide is used to control invertebrate pests. This invention discloses a pyrimidinone metronidazole compound, which, compared with conventional insecticides such as trifluralin and flonicamid, exhibits significantly improved activity and enhanced toxicity for pest control.