7 results about "Clotrimazole" patented technology

The application belongs to the technical field of medical intermediates, and relates to a production method of a clotrimazole intermediate (2-chlorophenyl)diphenylmethanol. In the method, 2-methyltetrahydrofuran or cyclopentyl methyl ether is used as a reaction solvent, an ethyl o-chlorobenzoate solution is added dropwise into a phenyl magnesium bromide solution with a concentration of 2.5-3.5 M under the conditions of 60-80 DEG C and inert atmosphere, the reaction is continuously carried out after the dropwise addition is completed, a water solution of a quenching agent is added after the reaction to quench, then, liquid separation is carried out, and the organic phase after the liquid separation is concentrated to obtain a crude product; the crude product is refined by using a reaction solvent and petroleum ether, and (2-chlorophenyl)diphenylmethanol is obtained. The production method can efficiently and stably produce high-quality (2-chlorophenyl)diphenylmethanol, reduces production cost and safety hazards, and can be used for large-scale industrial production.

1. The name of the design product: medicine packaging box (clotrimazole cream). 2. The use of the design product: used for packaging and storing medicines and medical products. 3. The design points of the design product: in shape. 4. The picture or photo that best indicates the design points: perspective view.

The invention relates to a compound medicine for treating vulva lichen sclerosus. The compound medicine is prepared from methylrosanilinium chloride, aminoglycoside antibiotics, glucocorticoid, pyrrole broad-spectrum antifungal drugs and pharmaceutic adjuvants. The aminoglycoside antibiotic is tobramycin, the glucocorticoid is dexamethasone, and the pyrrole broad-spectrum antifungal drug is clotrimazole. The compound medicine is ointment or water aqua.

A method of using a pharmaceutical composition comprising metronidazole, clotrimazole and chlorhexidine for treating patients suffering from hemorrhoids, is disclosed. The mixture of metronidazole, clotrimazole and chlorhexidine can be applied to contact the hemorrhoids to relieve and / or reduce the symptoms caused by the hemorrhoids. Various application forms including solid forms and solution forms of the mixture of compounds can be used to treat the hemorrhoids.

The invention belongs to the technical field of hand and foot nursing, and discloses a non-corrosive body surface cutin hyperplasia nursing patch as well as a preparation method and application thereof. The nursing patch is sequentially provided with a three-layer basic structure including a bacteriostatic functional layer, a flexible substrate and a breathable protective layer from the skin contact side to the outer side, the bacteriostatic functional layer is compounded by clotrimazole, bifonazole and ketoconazole, and the mass ratio of clotrimazole to bifonazole to ketoconazole is (1-2): (1.5-2.5): (0.6-1.5). According to the non-corrosive body surface cutin hyperplasia nursing patch, the root of cutin abnormal hyperplasia is cut off through the antibacterial components, meanwhile, cutin is mildly softened and ablated, and normal skin barriers are not damaged.

The present invention relates to a formulation and method for treating an ear infection, especially otomycosis and otitis externa, by administering a one-time only treatment comprising an antibiotic, antifungal, and an anti-inflammatory in a thick, otic carrier. In one embodiment, the formulation comprises a therapeutically effective amount of active ingredients including a marbofloxacin, terbinafine and / or clotrimazole and dexamethasone.

The present application relates to a kind of lactobacillus johnsonii and application, belong to microbial technology field.Lactobacillus johnsonii JoA9-1 of the present application is preserved in China typical culture preservation center, and the preservation number is CCTCCM2025369.Lactobacillus johnsonii JoA9-1 of the present application has no virulence factor, does not hemolyze, and has good safety, and its beneficial effect is: can produce multiple organic acids and has tolerance to acidic environment, can adapt and maintain the acidic environment of female genital tract;Can inhibit the propagation of pathogenic bacteria;Can inhibit the formation of Candida albicans hypha;It has immune regulation function, and the inhibitory effect on inflammatory factor TNF alpha is superior to clotrimazole treatment, can significantly enhance mouse vaginitis treatment;Treatment occurs in the site of vagina infection, can repair the local tissue of Candida albicans vaginitis mouse;Regulate the relative abundance of vaginal microbial flora after Candida albicans vaginitis infection of mouse, restore vaginal microbial flora environment.