5 results about "Vaginal gel" patented technology

The application discloses a preparation method of a progesterone vaginal gel, relates to the technical field of gynecological medicine preparation, and realizes the preparation method of the progesterone vaginal gel by using a preparation device of the progesterone vaginal gel. The preparation device of the progesterone vaginal gel comprises a mixing kettle, a top plate is fixedly arranged at the top of the mixing kettle, a driving scraping mechanism is arranged inside the mixing kettle and at the inner side of the top plate, an oil phase preparation mechanism is arranged outside the driving scraping mechanism, a water phase preparation mechanism is arranged at the bottom outside the oil phase preparation mechanism, a premix preparation mechanism is arranged at the top outside the oil phase preparation mechanism, and the top plate and the water phase preparation mechanism are jointly provided with a driving supporting mechanism. The application can effectively shorten the transfer time of the premix and the oil phase, thereby improving the preparation efficiency of the gel product, and the residual oil phase can be recycled, thereby avoiding the waste of the oil phase and guaranteeing the quality of the gel product.

The invention relates to the technical field of medical biopolymer materials, in particular to a two-component gynecological gel spray and a using method thereof.The two-component gynecological gel spray comprises a first component and a second component, and the first component at least comprises formylated multi-arm polyethylene glycol, formylated poloxamer and a solvent; the second component at least comprises a multi-amino polymer solution, the bi-component solution forms a film in the vagina and is cured in situ, and the vaginal gel has the characteristics of strong adhesion and strong corrosion resistance, can act on the vagina for a long time to realize long-acting treatment, and is more convenient to use and better in effect.

The invention belongs to the field of preparation of high-antibacterial carbon dots, and discloses a high-antibacterial carbon dot, a preparation process and application of the high-antibacterial carbon dot in vaginal gel. The prepared carbon dots are prepared by adopting physical shearing and ultrasonic synergistic pretreatment, then cooperating with microwave gradient energy crushing and stripping, and then performing centrifugation, dialysis purification and vacuum freeze drying, the damage of oxidation or acid treatment to a graphite structure is avoided in the whole process, and the carbon dots have excellent antibacterial and antiviral performance, can effectively inactivate various pathogenic microorganisms, and have good application prospects. Comprise herpes simplex virus, human papilloma virus HPV16, staphylococcus aureus, candida albicans and the like. The invention also optimizes application conditions, is suitable for developing efficient and safe vagina antibacterial gel products, and provides an innovative solution for preventing and treating gynecological infection.

This invention belongs to the field of biomedicine and discloses the application of HMOX1 inhibitors in the preparation of drugs for treating senile vaginitis. This invention is the first to discover that the content of the metabolite MESV1 (Guggulsterone) is significantly elevated in the vaginal secretions of patients with senile vaginitis. MESV1 induces ferroptosis in vaginal epithelial cells by upregulating HMOX1 protein expression, thereby driving the disease. Based on this, this invention proposes a novel therapeutic strategy targeting HMOX1. The inhibitors include shRNAs targeting HMOX1 (such as SEQ ID NO: 1-3), which can be prepared into vaginal gels, creams, and other dosage forms. Simultaneously, MESV1 can also be used to prepare auxiliary diagnostic kits. This invention provides a novel target and precise treatment approach for non-hormonal treatment of senile vaginitis.

The invention provides an antibody combined with HPV66 L1 protein or an antigen binding fragment thereof and a pharmaceutical composition containing the antibody, and further provides a polynucleotide molecule for coding the antibody or the antigen binding fragment thereof, and an expression vector for expressing the antibody or the antigen binding fragment thereof. The antibody or the antigen binding fragment thereof can be widely applied to infection detection of the HPV66 virus in a clinical sample, can be prepared into vaginal gel, vaginal cleaning liquid, external washing liquid, vaginal suppository, freeze-dried powder, vaginal effervescent tablets and the like, is used for prevention and / or treatment of HPV66 infected patients, and can effectively improve the clinical negative conversion rate of the HPV66 patients. The invention has important significance on female reproductive health and public health prevention and control.