9 results about "Vaginal gel" patented technology

The invention relates to the technical field of medical gel preparation, in particular to propolis temperature-sensitive in-situ gel as well as a preparation method and application thereof. A gel matrix is screened by adopting a single factor test, a prescription is optimized by adopting a star point design-effect surface method, and the quality of the propolis temperature-sensitive gel is evaluated. The optimal prescription of the propolis temperature-sensitive vaginal gel obtained through experimental optimization is as follows: 22.9% of poloxamer 407, 1.8% of poloxamer P188, 5.4% of polyethylene glycol 400 and 5% of propolis, the gelling temperature before dilution is 25 DEG C, and the gelling temperature after dilution is 37 DEG C. Quality evaluation results show that the antibacterial agent is stable in property, proper in gelling temperature and good in antibacterial activity. The prepared propolis temperature-sensitive vaginal gel is stable in process, uniform in appearance, controllable in quality and good in slow-release effect and antibacterial effect.

The application discloses a preparation method of a progesterone vaginal gel, relates to the technical field of gynecological medicine preparation, and realizes the preparation method of the progesterone vaginal gel by using a preparation device of the progesterone vaginal gel. The preparation device of the progesterone vaginal gel comprises a mixing kettle, a top plate is fixedly arranged at the top of the mixing kettle, a driving scraping mechanism is arranged inside the mixing kettle and at the inner side of the top plate, an oil phase preparation mechanism is arranged outside the driving scraping mechanism, a water phase preparation mechanism is arranged at the bottom outside the oil phase preparation mechanism, a premix preparation mechanism is arranged at the top outside the oil phase preparation mechanism, and the top plate and the water phase preparation mechanism are jointly provided with a driving supporting mechanism. The application can effectively shorten the transfer time of the premix and the oil phase, thereby improving the preparation efficiency of the gel product, and the residual oil phase can be recycled, thereby avoiding the waste of the oil phase and guaranteeing the quality of the gel product.

The invention relates to the technical field of medical biopolymer materials, in particular to a two-component gynecological gel spray and a using method thereof.The two-component gynecological gel spray comprises a first component and a second component, and the first component at least comprises formylated multi-arm polyethylene glycol, formylated poloxamer and a solvent; the second component at least comprises a multi-amino polymer solution, the bi-component solution forms a film in the vagina and is cured in situ, and the vaginal gel has the characteristics of strong adhesion and strong corrosion resistance, can act on the vagina for a long time to realize long-acting treatment, and is more convenient to use and better in effect.

The invention belongs to the field of preparation of high-antibacterial carbon dots, and discloses a high-antibacterial carbon dot, a preparation process and application of the high-antibacterial carbon dot in vaginal gel. The prepared carbon dots are prepared by adopting physical shearing and ultrasonic synergistic pretreatment, then cooperating with microwave gradient energy crushing and stripping, and then performing centrifugation, dialysis purification and vacuum freeze drying, the damage of oxidation or acid treatment to a graphite structure is avoided in the whole process, and the carbon dots have excellent antibacterial and antiviral performance, can effectively inactivate various pathogenic microorganisms, and have good application prospects. Comprise herpes simplex virus, human papilloma virus HPV16, staphylococcus aureus, candida albicans and the like. The invention also optimizes application conditions, is suitable for developing efficient and safe vagina antibacterial gel products, and provides an innovative solution for preventing and treating gynecological infection.

The invention discloses a female private care gel with multiple effects and a preparation method thereof. The gel is prepared from the following components: carbomer 980, palmitoyl 3 peptide, phenethyl caffeate, glycerol, pentanediol, sodium hyaluronate, hydrolyzed sodium hyaluronate, panthenol, glycerol glucoside, crithmum maritimum callus fermentation filtrate, lysozyme, an ecological nutrient solution and the balance of water. According to the female private care gel disclosed by the invention, through a scientific formula and a reasonable preparation process, the synergistic effect of all the components is fully exerted, the use limitation of palmitoyl 3 peptide in vaginal gel is effectively solved, and the gel can better adapt to the vaginal environment, promote the production of collagen and realize the effects of tightening and moisturizing. Meanwhile, the product has multiple effects of repairing in vitro, moisturizing, relieving, resisting inflammation, regulating flora balance and the like, comprehensively cares female private health, and has a wide market application prospect.

This invention belongs to the field of biomedicine and discloses the application of HMOX1 inhibitors in the preparation of drugs for treating senile vaginitis. This invention is the first to discover that the content of the metabolite MESV1 (Guggulsterone) is significantly elevated in the vaginal secretions of patients with senile vaginitis. MESV1 induces ferroptosis in vaginal epithelial cells by upregulating HMOX1 protein expression, thereby driving the disease. Based on this, this invention proposes a novel therapeutic strategy targeting HMOX1. The inhibitors include shRNAs targeting HMOX1 (such as SEQ ID NO: 1-3), which can be prepared into vaginal gels, creams, and other dosage forms. Simultaneously, MESV1 can also be used to prepare auxiliary diagnostic kits. This invention provides a novel target and precise treatment approach for non-hormonal treatment of senile vaginitis.

The invention provides an antibody combined with HPV66 L1 protein or an antigen binding fragment thereof and a pharmaceutical composition containing the antibody, and further provides a polynucleotide molecule for coding the antibody or the antigen binding fragment thereof, and an expression vector for expressing the antibody or the antigen binding fragment thereof. The antibody or the antigen binding fragment thereof can be widely applied to infection detection of the HPV66 virus in a clinical sample, can be prepared into vaginal gel, vaginal cleaning liquid, external washing liquid, vaginal suppository, freeze-dried powder, vaginal effervescent tablets and the like, is used for prevention and / or treatment of HPV66 infected patients, and can effectively improve the clinical negative conversion rate of the HPV66 patients. The invention has important significance on female reproductive health and public health prevention and control.

The invention discloses lactobacillus crispatus, a microbial inoculum and a preparation method and application of the lactobacillus crispatus and the microbial inoculum. The lactobacillus crispatus disclosed by the invention is lactobacillus crispatus OH126 of which the preservation number is GDMCC (China General Microbiological Culture Collection Center) No.66536. The lactobacillus crispatus newly researched and developed in the invention can effectively inhibit growth of common vaginal pathogenic bacteria, is adaptive to a vaginal micro-ecological environment, has good vaginal mucosa colonization ability, and can also assist in improving related symptoms of hysteromyoma. Meanwhile, vaginal freeze-dried tablets, vaginal gel and other microbial agents can be prepared, and the activity and storage stability of thalli are ensured by optimizing the preparation process. The strain and the microbial inoculum can be used for adjusting female vagina micro-ecological balance, treating or preventing bacterial vaginitis and assisting in improving related symptoms of hysteromyoma, and a new scheme and a new way are provided for prevention and treatment of female reproductive system diseases such as bacterial vaginitis and hysteromyoma.

The invention discloses anti-aging, moisturizing and antibacterial vaginal gel, and belongs to the field of daily necessities for health. The gel is composed of a solution A, a solution B and a solution C, wherein the solution A contains 15-25 parts of glycerol, 10-15 parts of sodium hyaluronate and 1-5 parts of xanthan gum; the solution B is prepared from 0.5 to 2 parts of hydroxyethyl cellulose and 1 to 2 parts of carboxymethyl chitosan; the solution C contains 0.5-3 parts of beta-nicotinamide mononucleotide, 0.5-1.5 parts of an antibacterial agent and 0.1-0.8 part of a transdermal absorption enhancer, and further contains coenzyme Q10 and a centella asiatica extract or a lactobacillus fermentation product on the basis. The antibacterial rate of the vaginal gel to pathogenic bacteria is greater than or equal to 99.5%, lactobacilli are not interfered, vaginal epithelial cell collagen can be improved by 35% or above, the mitochondrial activity can be improved by 40%, and the vaginal gel is suitable for preventing infection, delaying tissue aging and maintaining micro-ecological balance and can also be combined with clotrimazole to enhance the antifungal curative effect.