39 results about "Clindamycin Phosphate" patented technology

The invention discloses an AI (artificial intelligence)-based clindamycin phosphate processing hydrolysis optimization method and an AI-based clindamycin phosphate processing hydrolysis optimization system. According to the method, a reaction process prediction model capable of representing a process bifurcation phenomenon and fusing a chemical reaction mechanism and process data is constructed, and the model is utilized to train a multi-target decision-making agent. In the training process, causal relationship analysis is utilized to guide exploration of the intelligent agent, dynamic security constraints based on a chemical mechanism are introduced, and finally a strategy set covering the Pareto optimal frontier is generated. An operator can select a strategy according to production requirements, and closed-loop self-adaptive control is carried out by the system. The method aims to solve the problem of multi-target dynamic optimization caused by process bifurcation in the hydrolysis process, balance of multiple conflict targets such as yield, impurities and energy consumption is achieved by actively controlling the process bifurcation, and the robustness, safety and stability of the process are improved.

The invention discloses a clindamycin phosphate processing hydrolysis device and method, and particularly relates to the technical field of injection preparation, the clindamycin phosphate processing hydrolysis device comprises a supporting frame, a hydrolysis mixing assembly is arranged on the supporting frame, the hydrolysis mixing assembly comprises a sliding seat arranged on the supporting frame, the sliding seat is in sliding connection with the supporting frame, and a hydrolysis cylinder is arranged at the bottom of the sliding seat. Clindamycin phosphate powder is prevented from being stacked together due to friction force, the amplitude plate and the heating plate can generate high-frequency amplitude, raw liquid clindamycin phosphate powder molecules can be fully mixed together easily, meanwhile, the temperature of the raw liquid clindamycin phosphate powder during evolutionary hydrolysis can be controlled through the heating plate, and therefore the raw liquid clindamycin phosphate powder can be obtained. Compressed airflow is conveyed into the aeration pipe, is aerated in the hydrolysis cylinder through the aeration pipe, and is stirred by matching with the rotation of the connecting disc, the filter screen plate, the first stirring blade and the second stirring blade, so that the caking of a stock solution and lindamycin phosphate powder can be effectively avoided, and the hydrolysis quality and effect are ensured.

The invention discloses a clindamycin phosphate crystallization tracing method and system based on a block chain, and belongs to the technical field of medicine manufacturing process control. The method comprises the following steps: collecting multi-modal data of a crystallization process in real time through a Raman spectrum sensor, an FBRM sensor and other process analysis technology sensors; constructing a dynamic space-time atlas based on the data to characterize a process state; deeply analyzing the map by using a time-space diagram neural network model so as to identify key crystallization events such as nucleation and crystal transformation; the AI oracle machine automatically generates an event certificate containing event details, an original data hash value and a digital signature for the identified CCE; and finally, submitting the certificate as a transaction to a block chain network for uplink evidence storage, and forming a tamper-resistant tracing record. According to the method, the AI and block chain technologies are fused, so that the problem that key microscopic events are lack of credible and non-tampering records in the crystallization process is solved, and a high-fidelity tracing record with cryptographic guarantee is provided for the pharmaceutical production process.

The invention discloses a clindamycin phosphate vaginal gel preparation device and method, and belongs to the technical field of pharmacy. The method comprises the steps that after clindamycin phosphate vaginal gel is prepared by a preparation tank, the clindamycin phosphate vaginal gel is filled into a vacuum defoaming tank through a feeding opening in the bottom of the vacuum defoaming tank, and a packaging tank is conveyed to a rotary positioning mechanism through a conveying mechanism; and the filling mechanism is used for filling the clindamycin phosphate vaginal gel stored in the vacuum defoaming tank into the packaging tank on the rotary positioning mechanism. The invention aims to solve the problems that the existing clindamycin phosphate vaginal gel is complex in preparation process and difficult to carry out constant temperature control, the preparation and filling process needs to be transferred for multiple times, the viscosity of the gel can change along with time, temperature or storage conditions, the uniformity of the gel and the use experience of a patient are influenced, and the gel is difficult to be used. And the filled finished product gel is very easy to have a large number of bubbles, so that a more transparent and uniform gel product can be obtained, and the physical property and the use comfort of the gel are improved.

The invention discloses a clindamycin phosphate vaginal gel detection method and device, and relates to the technical field of vaginal gel detection. The detection method comprises the following steps: step 1, respectively putting a monopotassium phosphate solution and acetonitrile into two raw material supply tanks, putting clindamycin phosphate vaginal gel to be detected into a preparation tank, and leading the two raw material supply tanks to the preparation tank for adding raw materials; step 2, placing a plurality of preparation tanks on a bottle-changing rotating disc, rotating the bottle-changing rotating disc when the adding amount of the preparation tanks in which the clindamycin phosphate vaginal gel to be detected is added meets the requirement, adjusting the positions of the preparation tanks, and transferring the clindamycin phosphate vaginal gel to the bottle-changing rotating disc; rotating a bottle-changing rotating disc and pushing a tank-making device containing clindamycin phosphate vaginal gel to be detected onto a telescopic assembly; raw materials can be automatically configured, configuration can be completed in the process of moving the preparation tank, the configuration efficiency is improved, the preparation tank is limited through the supporting frame and the synchronous pushing assembly together after carrying, and the preparation tank is fixed, so that the subsequent liquid taking process is facilitated.

This invention discloses a clindamycin phosphate processing hydrolysis apparatus and method, specifically relating to the field of injection preparation technology. The apparatus includes a support frame with a hydrolysis mixing component mounted on it. The hydrolysis mixing component includes a slide seat mounted on the support frame, slidably connected to the support frame, and a hydrolysis cylinder at the bottom of the slide seat. This invention prevents clindamycin phosphate powder from agglomerating due to friction. The amplitude plate and heating plate generate high-frequency amplitude, facilitating thorough mixing of the clindamycin phosphate powder molecules. Simultaneously, the heating plate controls the temperature during hydrolysis. Compressed airflow is delivered to an aeration pipe, which aerates the powder within the hydrolysis cylinder. Furthermore, the rotating connection disc, filter plate, first stirring blade, and second stirring blade further agitate the powder, effectively preventing clumping of the clindamycin phosphate powder and ensuring hydrolysis quality and effectiveness.

The invention relates to the technical field of chemical synthesis, in particular to a preparation process of clindamycin phosphate, which comprises the following preparation steps: chlorination reaction, alcoholization reaction, ketonization reaction and esterification reaction. Adding 50-55 parts by weight of phosphorus oxychloride, 340-380 parts by weight of a chelating agent and 60-70 parts by weight of triethylamine, and stirring until the materials are dissolved; the preparation method comprises the following steps: adding acetone into clindamycin propylidene until the acetone is completely dissolved, then adding the acetone into the clindamycin propylidene, keeping the temperature at 5-15 DEG C to react for 4-8 hours, and then hydrolyzing, removing a chelating agent, decolorizing, adsorbing, desorbing and crystallizing to obtain a clindamycin phosphate finished product, the method has the advantages of reducing emission of pyridine hydrochloride and reducing environmental pollution.

The invention discloses an external clindamycin phosphate solution, which is prepared from the following raw materials in parts by weight: 0.6 to 1.2 parts of clindamycin phosphate, 0.1 to 0.2 part of resveratrol, 0.02 to 0.04 part of glutathione, 0.1 to 0.2 part of xanthan gum, 0.3 to 0.6 part of poloxamer, 25 to 32 parts of glycerol and the balance of water according to the weight of 100 parts. The traditional Chinese medicine composition can be stored for a long time, is good in medicine stability, and can well relieve side effects such as dry skin, sensitive irritation and skin rash.

The application provides a clindamycin phosphate external solution and a preparation method thereof. The clindamycin phosphate external solution has good stability and simple preparation process, and can be mass-produced by adding sodium hydroxide and triethanolamine in the solution preparation process and using polyvinylidene fluoride (PVDF) as a filter membrane material.

The application belongs to the technical field of injection liquid, and provides a clindamycin phosphate injection solution and a preparation method thereof.The preparation method comprises the following steps: S1, 75-85 mL of water for injection is taken, (0.5-0.6) g of clindamycin phosphate is added into the water for injection, and after stirring and dissolving, a stabilizer is added, and stirring and dissolving are continued to obtain a base solution; S2, Zn-O-C bonded activated carbon is added into the base solution, the pH is adjusted to 5.3-5.5, then 15-25 mL of water for injection is added, and stirring and filtration are conducted, and the clindamycin phosphate injection solution is obtained.The content of clindamycin phosphate is increased by increasing the amount of activated carbon, so that the related substances (total impurities) are reduced.

This invention belongs to the field of antibiotic raw material preparation, and provides a clindamycin phosphate raw material and its preparation method. The method first purifies a crude aqueous solution containing clindamycin phosphate using a bifunctional mesoporous silica adsorbent, then employs antisolvent crystallization induced by activated seed crystals, followed by drying to obtain the raw material. The obtained raw material has high purity, low total related substances (TLS) and low maximum single related substance (MSLS), controllable moisture content and particle size, and balances the engineering applicability and crystallization processability of granular fixed-bed packing. It alleviates the difficulties in balancing high-selectivity purification with fixed-bed compatibility, particle size processability, and high purity with low MSLS levels, and is suitable for the preparation and scale-up application of clindamycin phosphate raw materials.

The application discloses a kind of clindamycin phosphate crystallization traceability method and system based on blockchain, belong to the technical field of drug manufacturing process control.The method comprises: by Raman spectrum, FBRM etc. process analysis technology sensor real-time acquisition of the multi-modal data of crystallization process;Based on the data, a dynamic space-time atlas is constructed to represent the process state;Deep analysis of the atlas using a space-time graph neural network model to identify key crystallization events such as nucleation, crystal transformation;From the AI prophet, for the identified CCE, automatically generate an event certificate containing event details, original data hash value and digital signature;Finally, the certificate is submitted as a transaction to the blockchain network for on-chain storage, forming an unalterable traceability record.The present application solves the problem of lack of credible and unalterable records of key microscopic events in the crystallization process by integrating AI and blockchain technology, providing high-fidelity and cryptographically secure traceability records for pharmaceutical production processes.

The disclosure provides a topical gel formulation comprising 1-1.5 wt. % clindamycin phosphate, 2.5-3.5 wt. % benzoyl peroxide, and 0.1-0.2 wt. % adapalene, in combination with a gelling agent, a polyhydric alcohol, and water, useful in treating inflammatory skin conditions, including acne, together with methods of making and using the same.

The invention discloses a separation and purification method of clindamycin phosphate, which comprises the following steps: S1, diluting and filtering a clindamycin phosphate reaction solution, and taking the obtained filtrate as a loading solution; s2, the obtained loading solution is separated and purified through preparative high performance liquid chromatography, a silica gel filler modified by a polar group and a non-polar group is adopted as a chromatographic column, and a mixed solution of a non-polar solvent and a polar solvent is adopted as an eluent. The high-efficiency separation and purification method of the high-purity clindamycin phosphate has the advantages of desalination and removal of organic impurities, easy realization of industrial production, good repeatability, simple and controllable operation, easy realization of automation, and stable process.

The invention relates to the technical field of medicine, in particular to a local medicine preparation composition for improving skin disease symptoms and application thereof. The invention relates to a topical pharmaceutical preparation composition for improving skin disease symptoms. The topical pharmaceutical preparation composition comprises clindamycin phosphate, an echinacea extract, a solvent and a dermatologically acceptable carrier. According to the local pharmaceutical preparation composition for improving skin disease symptoms, through the synergistic effect of the clindamycin phosphate and the echinacea purpurea extract, a safer, more effective and more stable treatment scheme is provided, and a good curative effect is expected to be achieved in clinical practice.

1. Name of the product of this design: Packaging kit (clindamycin phosphate topical solution). 2. Purpose of this design product: used for product packaging. 3. The key design point of this product lies in the combination of pattern and color. 4. The image or photo that best illustrates the key design features: Kit 1 main view. 5. The design for which protection is sought includes color.

The present invention discloses a clindamycin phosphate rapid crystallization apparatus, and particularly relates to the technical field of crystallization apparatuses, the clindamycin phosphate rapid crystallization apparatus comprises a base, the base is provided with a separation crystallization assembly, the separation crystallization assembly comprises a crystallization cylinder arranged on the top of the base, and the top of the crystallization cylinder is sleeved with a heating cylinder. Raw materials between the lining filter cylinder and the locking block can be separated through the lining filter cylinder, impurities can be reserved in the lining filter cylinder, the raw materials can be easily separated and filtered, the follow-up crystallization efficiency and effect of the raw materials are ensured, heat conduction heating is conducted through the second flow dividing cone block, and the crystallization efficiency of the raw materials is improved. The separated raw materials are crystallized in the crystallization cylinder and are gathered together through the filter element, so that the resistance between the raw materials and the extension rod and the filter element during rotation is increased, the stirring efficiency and effect of the raw materials during separation are improved, impurities are easily separated into the lining filter cylinder, and the crystallization effect of the separated raw materials is ensured.

The present application belongs to the technical field of chemical drug synthesis, and specifically relates to a method for preparing lincomycin phosphate using clindamycin phosphate. The method (1) adds clindamycin phosphate to a solvent and fully dissolves it, then adds a base, heats it to 50-100°C, and performs a hydrolysis reaction for 1-20 hours; (2) after the reaction in step (1) is completed, the mixed solution is successively subjected to resin adsorption, desorption, and recrystallization to obtain lincomycin phosphate. The main purpose of the present application is to successfully prepare the impurity, thereby providing a high-purity standard product for the qualitative and quantitative analysis of impurities in the subsequent preparation or storage of clindamycin phosphate, thereby laying a good foundation for the stable quality and safe use of clindamycin phosphate, and also laying a good product foundation for the in-depth study of the antibacterial properties of lincomycin phosphate. Therefore, the present application has good practical application significance.

1. Name of the product in this design: Packaging Box (Clindamycin Phosphate Benzoyl Peroxide Gel). 2. Purpose of this design: Product packaging. 3. The key design elements of this product are the combination of shape, pattern, and color. 4. The image or photograph that best illustrates the design's key features: the front view. 5. The design for which protection is sought includes color. 6. Other situations requiring explanation: The boxes in the top and bottom views represent the barcode area.

The invention discloses a clindamycin phosphate topical solution, belonging to the technical field of pharmaceutical solutions. The invention prepares a clindamycin phosphate topical solution based on a deep eutectic solvent. The clindamycin phosphate topical solution prepared by the invention has less raw materials used, low concentration, storage stability, drug efficacy maintenance, and can well alleviate side effects such as skin itching and dryness when patients take the medicine.

The invention relates to the technical field of medicine synthesis, in particular to a preparation method of a clindamycin phosphate intermediate. According to the preparation method of the clindamycin phosphate intermediate, the lincomycin hydrochloride and the Vilsmeier reagent are used as starting raw materials, the material ratio is accurately controlled through the micro-mixer and the micro-channel reactor, the stereochemical selectivity of the chlorination step is remarkably improved, the reaction rate is effectively increased, and through continuous preparation, the yield of the clindamycin phosphate intermediate is increased. Compared with the prior art, the method provided by the invention has the advantages that the production of 7-epiclindamycin impurities is reduced, the subsequent purification cost is reduced, the control of the 7-epiclindamycin impurities is realized, the 7-epiclindamycin impurities can be completely removed after the product is crystallized once, and the yield reaches 95-98%.

The invention discloses a preparation method of a clindamycin phosphate impurity, which comprises the following steps: when the clindamycin phosphate impurity N is prepared, firstly protecting hydroxyl by using clindamycin hydrochloride as a raw material, then oxidizing a thiomethyl group by using an oxidizing agent, then carrying out phosphorylation reaction by using phosphorus oxychloride, and finally hydrolyzing to obtain the target impurity N. The clindamycin phosphate impurity N prepared by the method disclosed by the invention is relatively high in purity, can be used as an impurity reference substance for clindamycin phosphate analysis, and is used for controlling the quality of clindamycin phosphate, so that the medication safety is ensured.

The invention discloses a preparation method of clindamycin phosphate injection, and belongs to the field of pharmacy. The preparation method of the clindamycin phosphate injection comprises the following steps: sequentially and respectively dissolving the auxiliary materials edetate disodium and sodium hydroxide, then dissolving the raw material clindamycin phosphate to completely dissolve the raw material in a stable solution state, then complementing the water for injection, and carrying out multiple filter element filtration, filling, full plug pressing and capping to obtain the clindamycin phosphate injection. The clindamycin phosphate injection is obtained. The clindamycin phosphate injection obtained by the preparation method disclosed by the invention is good in quality.

The disclosure provides a topical gel formulation comprising 1-1.5 wt. % clindamycin phosphate, 2.5-3.5 wt. % benzoyl peroxide, and 0.1-0.2 wt. % adapalene, in combination with a gelling agent, a polyhydric alcohol, and water, useful in treating inflammatory skin conditions, including acne, together with methods of making and using the same.

The present application relates to the technical field of drug synthesis, and particularly relates to a preparation method of clindamycin phosphate intermediate. The preparation method of the clindamycin phosphate intermediate provided by the present application takes hydrochloric acid lincomycin and Vilsmeier reagent as starting materials, and precisely controls the material ratio through a micro-mixer and a micro-channel reactor, so that the stereochemical selectivity of the chlorination step is significantly improved, the reaction rate is effectively improved, the generation of 7-epi-clindamycin impurities is reduced through continuous preparation, the subsequent purification cost is reduced, the control of 7-epi-clindamycin impurities is realized, the 7-epi-clindamycin impurities can be completely removed after one-time crystallization of the product, and the yield reaches 95-98%.

The invention relates to the field of pharmaceutical preparations, in particular to a clindamycin metronidazole vaginal foaming agent and a preparation method thereof. The clindamycin and metronidazole vaginal foaming agent is prepared from the following components in parts by weight: 8 to 12 parts of clindamycin phosphate, 6 to 10 parts of metronidazole, 15 to 25 parts of alkyl glycoside, 50 to 70 parts of poloxamer, 100 to 150 parts of tetrafluoroethane, 4 to 28 parts of pH buffer agent, 50 to 60 parts of ethanol, 70 to 80 parts of propylene glycol and the balance of purified water, wherein the total part number is 1000. Through mutual cooperation of clindamycin phosphate and metronidazole, the growth of microorganisms is blocked through dual effects, the clindamycin phosphate and metronidazole are combined to cover a wider pathogen range, and especially the effect of inhibiting mixed anaerobic bacteria infection is better. In the formula, the alkyl glycoside and the poloxamer are matched for use, so that a foam liquid membrane can be stabilized, foaming can be accelerated, the foam defoaming time can be further prolonged, and the treatment effect of the clindamycin metronidazole vaginal foaming agent is guaranteed.

The invention relates to a novel method for purifying high-purity clindamycin phosphate, which comprises the following steps of: performing hot pulping on a clindamycin phosphate crude product in an amide solvent system to remove impurities, adding a benign solvent system to dissolve, decolorizing with activated carbon, and finally performing gradient cooling crystallization to obtain a clindamycin phosphate finished product. According to the purification method provided by the invention, an amide solvent system is adopted, so that a relatively good impurity removal effect is achieved, but the solubility of clindamycin phosphate is relatively poor. The content of clindamycin phosphate obtained by the purification method provided by the invention is higher than 98%, the content of impurity G is lower than 0.2%, and the total impurity content is lower than 2.0%.

The present invention discloses a rapid crystallization device for clindamycin phosphate, specifically relating to the technical field of crystallization devices, including a base, on which a separation and crystallization assembly is arranged. The separation and crystallization assembly includes a crystallization cylinder arranged on the top of the base, and a heating cylinder is sleeved on the top of the crystallization cylinder. In the present invention, the raw materials between the inner lining filter cylinder and the locking block can be separated through the inner lining filter cylinder, while the impurities can remain in the inner lining filter cylinder, which is easy to separate and filter the raw materials, ensuring the crystallization efficiency and effect of the subsequent raw materials. Through heat conduction heating by the second flow splitting cone block, the separated raw materials can be crystallized in the crystallization cylinder in a way that they gather together through the filter core, realizing an increase in the resistance between the raw materials and the extension rod and the filter core during rotation, thereby improving the stirring efficiency and effect of the raw materials during separation, making it easy for impurities to be separated in the inner lining filter cylinder, and ensuring the crystallization effect of the separated raw materials.

This invention relates to a gel preparation with pistachio shell extract as the active ingredient which has the effect of inhibiting Staphylococcus aureus bacteria. The gel consists of pistachio shell extract made from a maceration process using 70% alcohol, 5% CMC-Na gel base, 5.0% glycerin humectant, 3.0% propylene glycol, 0.25% methyl paraben preservative and aquades solvent added up to 100%. The gel has antibacterial activity which is characterized by the formation of an inhibition zone against Staphylococcus aureus bacteria. The emergence of this inhibition zone is due to the active compound contained in the gel base diffusing through the media so that it is able to inhibit the growth of Staphylococcus aureus bacteria. The positive control used in this antibacterial test is 1.2% clindamycin phosphate gel.From the results of the antibacterial effectiveness test that has been carried out, it was found that 10% to 25% pistachio shell extract gel can inhibit ≥15mm-24mm of Staphylococcus aureus bacterial growth with Minimum Inhibitory Concentration (MIC) and Minimum Bactericidal Concentration (MBC) values ​​of 80% and 100%, respectively.

The present invention provides topical gel formulations comprising 1 to 1.5% by weight of clindamycin phosphate, 2.5 to 3.5% by weight of benzoyl peroxide, and 0.1 to 0.2% by weight of adapalene, together with a gelling agent, a polyol, and water, for the treatment of inflammatory skin diseases, including acne, and methods of making and using the same.