20 results about "Clindamycin Phosphate" patented technology

The invention discloses an AI (artificial intelligence)-based clindamycin phosphate processing hydrolysis optimization method and an AI-based clindamycin phosphate processing hydrolysis optimization system. According to the method, a reaction process prediction model capable of representing a process bifurcation phenomenon and fusing a chemical reaction mechanism and process data is constructed, and the model is utilized to train a multi-target decision-making agent. In the training process, causal relationship analysis is utilized to guide exploration of the intelligent agent, dynamic security constraints based on a chemical mechanism are introduced, and finally a strategy set covering the Pareto optimal frontier is generated. An operator can select a strategy according to production requirements, and closed-loop self-adaptive control is carried out by the system. The method aims to solve the problem of multi-target dynamic optimization caused by process bifurcation in the hydrolysis process, balance of multiple conflict targets such as yield, impurities and energy consumption is achieved by actively controlling the process bifurcation, and the robustness, safety and stability of the process are improved.

The invention discloses a clindamycin phosphate crystallization tracing method and system based on a block chain, and belongs to the technical field of medicine manufacturing process control. The method comprises the following steps: collecting multi-modal data of a crystallization process in real time through a Raman spectrum sensor, an FBRM sensor and other process analysis technology sensors; constructing a dynamic space-time atlas based on the data to characterize a process state; deeply analyzing the map by using a time-space diagram neural network model so as to identify key crystallization events such as nucleation and crystal transformation; the AI oracle machine automatically generates an event certificate containing event details, an original data hash value and a digital signature for the identified CCE; and finally, submitting the certificate as a transaction to a block chain network for uplink evidence storage, and forming a tamper-resistant tracing record. According to the method, the AI and block chain technologies are fused, so that the problem that key microscopic events are lack of credible and non-tampering records in the crystallization process is solved, and a high-fidelity tracing record with cryptographic guarantee is provided for the pharmaceutical production process.

This invention discloses a clindamycin phosphate processing hydrolysis apparatus and method, specifically relating to the field of injection preparation technology. The apparatus includes a support frame with a hydrolysis mixing component mounted on it. The hydrolysis mixing component includes a slide seat mounted on the support frame, slidably connected to the support frame, and a hydrolysis cylinder at the bottom of the slide seat. This invention prevents clindamycin phosphate powder from agglomerating due to friction. The amplitude plate and heating plate generate high-frequency amplitude, facilitating thorough mixing of the clindamycin phosphate powder molecules. Simultaneously, the heating plate controls the temperature during hydrolysis. Compressed airflow is delivered to an aeration pipe, which aerates the powder within the hydrolysis cylinder. Furthermore, the rotating connection disc, filter plate, first stirring blade, and second stirring blade further agitate the powder, effectively preventing clumping of the clindamycin phosphate powder and ensuring hydrolysis quality and effectiveness.

The application provides a clindamycin phosphate external solution and a preparation method thereof. The clindamycin phosphate external solution has good stability and simple preparation process, and can be mass-produced by adding sodium hydroxide and triethanolamine in the solution preparation process and using polyvinylidene fluoride (PVDF) as a filter membrane material.

The application belongs to the technical field of injection liquid, and provides a clindamycin phosphate injection solution and a preparation method thereof.The preparation method comprises the following steps: S1, 75-85 mL of water for injection is taken, (0.5-0.6) g of clindamycin phosphate is added into the water for injection, and after stirring and dissolving, a stabilizer is added, and stirring and dissolving are continued to obtain a base solution; S2, Zn-O-C bonded activated carbon is added into the base solution, the pH is adjusted to 5.3-5.5, then 15-25 mL of water for injection is added, and stirring and filtration are conducted, and the clindamycin phosphate injection solution is obtained.The content of clindamycin phosphate is increased by increasing the amount of activated carbon, so that the related substances (total impurities) are reduced.

This invention belongs to the field of antibiotic raw material preparation, and provides a clindamycin phosphate raw material and its preparation method. The method first purifies a crude aqueous solution containing clindamycin phosphate using a bifunctional mesoporous silica adsorbent, then employs antisolvent crystallization induced by activated seed crystals, followed by drying to obtain the raw material. The obtained raw material has high purity, low total related substances (TLS) and low maximum single related substance (MSLS), controllable moisture content and particle size, and balances the engineering applicability and crystallization processability of granular fixed-bed packing. It alleviates the difficulties in balancing high-selectivity purification with fixed-bed compatibility, particle size processability, and high purity with low MSLS levels, and is suitable for the preparation and scale-up application of clindamycin phosphate raw materials.

The application discloses a kind of clindamycin phosphate crystallization traceability method and system based on blockchain, belong to the technical field of drug manufacturing process control.The method comprises: by Raman spectrum, FBRM etc. process analysis technology sensor real-time acquisition of the multi-modal data of crystallization process;Based on the data, a dynamic space-time atlas is constructed to represent the process state;Deep analysis of the atlas using a space-time graph neural network model to identify key crystallization events such as nucleation, crystal transformation;From the AI prophet, for the identified CCE, automatically generate an event certificate containing event details, original data hash value and digital signature;Finally, the certificate is submitted as a transaction to the blockchain network for on-chain storage, forming an unalterable traceability record.The present application solves the problem of lack of credible and unalterable records of key microscopic events in the crystallization process by integrating AI and blockchain technology, providing high-fidelity and cryptographically secure traceability records for pharmaceutical production processes.

The disclosure provides a topical gel formulation comprising 1-1.5 wt. % clindamycin phosphate, 2.5-3.5 wt. % benzoyl peroxide, and 0.1-0.2 wt. % adapalene, in combination with a gelling agent, a polyhydric alcohol, and water, useful in treating inflammatory skin conditions, including acne, together with methods of making and using the same.

The invention discloses a separation and purification method of clindamycin phosphate, which comprises the following steps: S1, diluting and filtering a clindamycin phosphate reaction solution, and taking the obtained filtrate as a loading solution; s2, the obtained loading solution is separated and purified through preparative high performance liquid chromatography, a silica gel filler modified by a polar group and a non-polar group is adopted as a chromatographic column, and a mixed solution of a non-polar solvent and a polar solvent is adopted as an eluent. The high-efficiency separation and purification method of the high-purity clindamycin phosphate has the advantages of desalination and removal of organic impurities, easy realization of industrial production, good repeatability, simple and controllable operation, easy realization of automation, and stable process.

1. Name of the product of this design: Packaging kit (clindamycin phosphate topical solution). 2. Purpose of this design product: used for product packaging. 3. The key design point of this product lies in the combination of pattern and color. 4. The image or photo that best illustrates the key design features: Kit 1 main view. 5. The design for which protection is sought includes color.

1. Name of the product in this design: Packaging Box (Clindamycin Phosphate Benzoyl Peroxide Gel). 2. Purpose of this design: Product packaging. 3. The key design elements of this product are the combination of shape, pattern, and color. 4. The image or photograph that best illustrates the design's key features: the front view. 5. The design for which protection is sought includes color. 6. Other situations requiring explanation: The boxes in the top and bottom views represent the barcode area.

The invention discloses a preparation method of a clindamycin phosphate impurity, which comprises the following steps: when the clindamycin phosphate impurity N is prepared, firstly protecting hydroxyl by using clindamycin hydrochloride as a raw material, then oxidizing a thiomethyl group by using an oxidizing agent, then carrying out phosphorylation reaction by using phosphorus oxychloride, and finally hydrolyzing to obtain the target impurity N. The clindamycin phosphate impurity N prepared by the method disclosed by the invention is relatively high in purity, can be used as an impurity reference substance for clindamycin phosphate analysis, and is used for controlling the quality of clindamycin phosphate, so that the medication safety is ensured.

The invention discloses a preparation method of clindamycin phosphate injection, and belongs to the field of pharmacy. The preparation method of the clindamycin phosphate injection comprises the following steps: sequentially and respectively dissolving the auxiliary materials edetate disodium and sodium hydroxide, then dissolving the raw material clindamycin phosphate to completely dissolve the raw material in a stable solution state, then complementing the water for injection, and carrying out multiple filter element filtration, filling, full plug pressing and capping to obtain the clindamycin phosphate injection. The clindamycin phosphate injection is obtained. The clindamycin phosphate injection obtained by the preparation method disclosed by the invention is good in quality.

The present application relates to the technical field of drug synthesis, and particularly relates to a preparation method of clindamycin phosphate intermediate. The preparation method of the clindamycin phosphate intermediate provided by the present application takes hydrochloric acid lincomycin and Vilsmeier reagent as starting materials, and precisely controls the material ratio through a micro-mixer and a micro-channel reactor, so that the stereochemical selectivity of the chlorination step is significantly improved, the reaction rate is effectively improved, the generation of 7-epi-clindamycin impurities is reduced through continuous preparation, the subsequent purification cost is reduced, the control of 7-epi-clindamycin impurities is realized, the 7-epi-clindamycin impurities can be completely removed after one-time crystallization of the product, and the yield reaches 95-98%.

The invention relates to the field of pharmaceutical preparations, in particular to a clindamycin metronidazole vaginal foaming agent and a preparation method thereof. The clindamycin and metronidazole vaginal foaming agent is prepared from the following components in parts by weight: 8 to 12 parts of clindamycin phosphate, 6 to 10 parts of metronidazole, 15 to 25 parts of alkyl glycoside, 50 to 70 parts of poloxamer, 100 to 150 parts of tetrafluoroethane, 4 to 28 parts of pH buffer agent, 50 to 60 parts of ethanol, 70 to 80 parts of propylene glycol and the balance of purified water, wherein the total part number is 1000. Through mutual cooperation of clindamycin phosphate and metronidazole, the growth of microorganisms is blocked through dual effects, the clindamycin phosphate and metronidazole are combined to cover a wider pathogen range, and especially the effect of inhibiting mixed anaerobic bacteria infection is better. In the formula, the alkyl glycoside and the poloxamer are matched for use, so that a foam liquid membrane can be stabilized, foaming can be accelerated, the foam defoaming time can be further prolonged, and the treatment effect of the clindamycin metronidazole vaginal foaming agent is guaranteed.

This invention relates to a gel preparation with pistachio shell extract as the active ingredient which has the effect of inhibiting Staphylococcus aureus bacteria. The gel consists of pistachio shell extract made from a maceration process using 70% alcohol, 5% CMC-Na gel base, 5.0% glycerin humectant, 3.0% propylene glycol, 0.25% methyl paraben preservative and aquades solvent added up to 100%. The gel has antibacterial activity which is characterized by the formation of an inhibition zone against Staphylococcus aureus bacteria. The emergence of this inhibition zone is due to the active compound contained in the gel base diffusing through the media so that it is able to inhibit the growth of Staphylococcus aureus bacteria. The positive control used in this antibacterial test is 1.2% clindamycin phosphate gel.From the results of the antibacterial effectiveness test that has been carried out, it was found that 10% to 25% pistachio shell extract gel can inhibit ≥15mm-24mm of Staphylococcus aureus bacterial growth with Minimum Inhibitory Concentration (MIC) and Minimum Bactericidal Concentration (MBC) values ​​of 80% and 100%, respectively.

The application discloses a kind of clindamycin phosphate processing hydrolysis optimization method and system based on AI.The method is by constructing a reaction process prediction model that can represent the "process bifurcation" phenomenon, which combines chemical reaction mechanism and process data, and trains a multi-objective decision-making agent using the model. During the training process, the agent's exploration is guided using causal relationship analysis, and dynamic safety constraints based on chemical mechanisms are introduced, resulting in a strategy set that covers the Pareto optimal frontier. Operators can select strategies based on production needs, and the system will perform closed-loop adaptive control. The application aims to solve the multi-objective dynamic optimization problem caused by process bifurcation in the hydrolysis process. By actively controlling the process bifurcation, the balance of multiple conflicting objectives such as yield, impurities, and energy consumption is achieved, improving the robustness, safety, and stability of the process.

The invention belongs to the technical field of pharmaceutical analysis, and particularly relates to a pretreatment method for detecting clindamycin phosphate gel related substances. Adding the clindamycin phosphate gel into the aluminum potassium sulfate solution, uniformly mixing, and fully reacting the carbomer with the aluminum potassium sulfate solution; after centrifugal separation, supernate is removed, and the obtained supernate is filtered. The pretreatment method provided by the invention not only can separate carbomer from other raw and auxiliary materials and improve the filtering rate so as to improve the detection efficiency, but also can effectively reduce the interference of auxiliary material peaks and improve the detection accuracy.

The disclosure provides a topical gel formulation comprising 1-1.5 wt. % clindamycin phosphate, 2.5-3.5 wt. % benzoyl peroxide, and 0.1-0.2 wt. % adapalene, in combination with a gelling agent, a polyhydric alcohol, and water, useful in treating inflammatory skin conditions, including acne, together with methods of making and using the same.

The invention provides a self-emulsifying external liniment containing clindamycin phosphate and application thereof, and the self-emulsifying external liniment comprises the following components by weight: 0.5%-2.0% of clindamycin phosphate, 10%-40% of an oil phase, 30%-60% of a surfactant, 10%-30% of a cosurfactant, and the balance of purified water. After the self-emulsifying external liniment is in contact with moisture, sweat and the like on the surface of skin, nano-scale emulsion droplets with extremely small particle sizes and uniform distribution can be spontaneously formed. The nano-emulsion droplet can smoothly pass through a skin microstructure, carries the drug and goes deep into hair follicles and sebaceous glands, and realizes precise delivery of propionibacterium acnes, so that the local bioavailability and the treatment effect of the drug are remarkably improved. As clindamycin phosphate is mainly dissolved in a hydrophobic microenvironment composed of the oil phase and the surfactant in a molecular state, direct contact between clindamycin phosphate and water molecules is greatly reduced, the hydrolytic degradation reaction of drugs can be effectively inhibited, and the validity period and shelf life of the product are remarkably prolonged.