11 results about "Clindamycin Phosphate" patented technology

This invention discloses a clindamycin phosphate processing hydrolysis apparatus and method, specifically relating to the field of injection preparation technology. The apparatus includes a support frame with a hydrolysis mixing component mounted on it. The hydrolysis mixing component includes a slide seat mounted on the support frame, slidably connected to the support frame, and a hydrolysis cylinder at the bottom of the slide seat. This invention prevents clindamycin phosphate powder from agglomerating due to friction. The amplitude plate and heating plate generate high-frequency amplitude, facilitating thorough mixing of the clindamycin phosphate powder molecules. Simultaneously, the heating plate controls the temperature during hydrolysis. Compressed airflow is delivered to an aeration pipe, which aerates the powder within the hydrolysis cylinder. Furthermore, the rotating connection disc, filter plate, first stirring blade, and second stirring blade further agitate the powder, effectively preventing clumping of the clindamycin phosphate powder and ensuring hydrolysis quality and effectiveness.

The application provides a clindamycin phosphate external solution and a preparation method thereof. The clindamycin phosphate external solution has good stability and simple preparation process, and can be mass-produced by adding sodium hydroxide and triethanolamine in the solution preparation process and using polyvinylidene fluoride (PVDF) as a filter membrane material.

The application belongs to the technical field of injection liquid, and provides a clindamycin phosphate injection solution and a preparation method thereof.The preparation method comprises the following steps: S1, 75-85 mL of water for injection is taken, (0.5-0.6) g of clindamycin phosphate is added into the water for injection, and after stirring and dissolving, a stabilizer is added, and stirring and dissolving are continued to obtain a base solution; S2, Zn-O-C bonded activated carbon is added into the base solution, the pH is adjusted to 5.3-5.5, then 15-25 mL of water for injection is added, and stirring and filtration are conducted, and the clindamycin phosphate injection solution is obtained.The content of clindamycin phosphate is increased by increasing the amount of activated carbon, so that the related substances (total impurities) are reduced.

This invention belongs to the field of antibiotic raw material preparation, and provides a clindamycin phosphate raw material and its preparation method. The method first purifies a crude aqueous solution containing clindamycin phosphate using a bifunctional mesoporous silica adsorbent, then employs antisolvent crystallization induced by activated seed crystals, followed by drying to obtain the raw material. The obtained raw material has high purity, low total related substances (TLS) and low maximum single related substance (MSLS), controllable moisture content and particle size, and balances the engineering applicability and crystallization processability of granular fixed-bed packing. It alleviates the difficulties in balancing high-selectivity purification with fixed-bed compatibility, particle size processability, and high purity with low MSLS levels, and is suitable for the preparation and scale-up application of clindamycin phosphate raw materials.

The disclosure provides a topical gel formulation comprising 1-1.5 wt. % clindamycin phosphate, 2.5-3.5 wt. % benzoyl peroxide, and 0.1-0.2 wt. % adapalene, in combination with a gelling agent, a polyhydric alcohol, and water, useful in treating inflammatory skin conditions, including acne, together with methods of making and using the same.

The invention discloses a separation and purification method of clindamycin phosphate, which comprises the following steps: S1, diluting and filtering a clindamycin phosphate reaction solution, and taking the obtained filtrate as a loading solution; s2, the obtained loading solution is separated and purified through preparative high performance liquid chromatography, a silica gel filler modified by a polar group and a non-polar group is adopted as a chromatographic column, and a mixed solution of a non-polar solvent and a polar solvent is adopted as an eluent. The high-efficiency separation and purification method of the high-purity clindamycin phosphate has the advantages of desalination and removal of organic impurities, easy realization of industrial production, good repeatability, simple and controllable operation, easy realization of automation, and stable process.

1. Name of the product in this design: Packaging Box (Clindamycin Phosphate Benzoyl Peroxide Gel). 2. Purpose of this design: Product packaging. 3. The key design elements of this product are the combination of shape, pattern, and color. 4. The image or photograph that best illustrates the design's key features: the front view. 5. The design for which protection is sought includes color. 6. Other situations requiring explanation: The boxes in the top and bottom views represent the barcode area.

The invention discloses a preparation method of a clindamycin phosphate impurity, which comprises the following steps: when the clindamycin phosphate impurity N is prepared, firstly protecting hydroxyl by using clindamycin hydrochloride as a raw material, then oxidizing a thiomethyl group by using an oxidizing agent, then carrying out phosphorylation reaction by using phosphorus oxychloride, and finally hydrolyzing to obtain the target impurity N. The clindamycin phosphate impurity N prepared by the method disclosed by the invention is relatively high in purity, can be used as an impurity reference substance for clindamycin phosphate analysis, and is used for controlling the quality of clindamycin phosphate, so that the medication safety is ensured.

The invention discloses a preparation method of clindamycin phosphate injection, and belongs to the field of pharmacy. The preparation method of the clindamycin phosphate injection comprises the following steps: sequentially and respectively dissolving the auxiliary materials edetate disodium and sodium hydroxide, then dissolving the raw material clindamycin phosphate to completely dissolve the raw material in a stable solution state, then complementing the water for injection, and carrying out multiple filter element filtration, filling, full plug pressing and capping to obtain the clindamycin phosphate injection. The clindamycin phosphate injection is obtained. The clindamycin phosphate injection obtained by the preparation method disclosed by the invention is good in quality.

This invention relates to a gel preparation with pistachio shell extract as the active ingredient which has the effect of inhibiting Staphylococcus aureus bacteria. The gel consists of pistachio shell extract made from a maceration process using 70% alcohol, 5% CMC-Na gel base, 5.0% glycerin humectant, 3.0% propylene glycol, 0.25% methyl paraben preservative and aquades solvent added up to 100%. The gel has antibacterial activity which is characterized by the formation of an inhibition zone against Staphylococcus aureus bacteria. The emergence of this inhibition zone is due to the active compound contained in the gel base diffusing through the media so that it is able to inhibit the growth of Staphylococcus aureus bacteria. The positive control used in this antibacterial test is 1.2% clindamycin phosphate gel.From the results of the antibacterial effectiveness test that has been carried out, it was found that 10% to 25% pistachio shell extract gel can inhibit ≥15mm-24mm of Staphylococcus aureus bacterial growth with Minimum Inhibitory Concentration (MIC) and Minimum Bactericidal Concentration (MBC) values ​​of 80% and 100%, respectively.

The invention belongs to the technical field of pharmaceutical analysis, and particularly relates to a pretreatment method for detecting clindamycin phosphate gel related substances. Adding the clindamycin phosphate gel into the aluminum potassium sulfate solution, uniformly mixing, and fully reacting the carbomer with the aluminum potassium sulfate solution; after centrifugal separation, supernate is removed, and the obtained supernate is filtered. The pretreatment method provided by the invention not only can separate carbomer from other raw and auxiliary materials and improve the filtering rate so as to improve the detection efficiency, but also can effectively reduce the interference of auxiliary material peaks and improve the detection accuracy.