146 results about "Vaginal mucosa" patented technology

Compositions comprising oligosaccharide aldonic acids are useful for general care, as well as for treatment and prevention, of various cosmetic conditions and dermatological disorders, including those associated with intrinsic and / or extrinsic aging, as well as with changes or damage caused by extrinsic factors; general care, as well as treatment and prevention of diseases and conditions, of the oral, and vaginal mucosa; for general oral care, as well as treatment and prevention of oral and gum diseases; and for wound healing of the skin. Compositions comprising oligosaccharide aldonic acids may further comprise a cosmetic, pharmaceutical or other topical agent to enhance or create synergetic effects.

A composition for enhancing absorption of a pharmaceutical which may have poor oral bioavailability, which composition has surprisingly little cytotoxicity, is provided which is in the form of a liquid or semi-solid or solid containing an admixture (1) a mucoadhesive polymer which is a polyacrylic acid polymer, preferably Carbopol 971P, and (2) an absorption or permeation enhancer which preferably is L-α-lyso-phosphatidylcholine (LPC), and which composition is free of polysaccharides. A method for improving bioavailability of a drug which has poor absorption properties is also provided wherein the above bioadhesive composition is administered with said pharmaceutical to the mucosal membrane of the GI tract, nose, oral cavity, sublingual, buccal, and vaginal mucosa. A method for reducing the cytotoxic effect of an absorption enhancer such as LPC is also provided wherein a mucoadhesive polymer as described above is administered with the LPC to a patient in need of treatment.

Bioadhesive films for delivery of active agent to the mucosa are disclosed. Particularly, bioadhesive films for treating the vaginal mucosa are disclosed.

A dual adhesive layer dosage form for delivery of active agent to and across, the mucosa is disclosed. Particularly, bioadhesive tablets for administration at the vaginal mucosa are disclosed as having a central active layer sandwiched between two bioadhesive layers.

Modified release oil in water emulsions that delivers drugs to a target tissue. The emulsions according to the present invention contain the lipophilic active ingredient completely dissolved into the hydrophobic internal phase stabilised by a polymeric surfactant. The presence of this polymer around the hydrophobic droplets avoids the migration of the active ingredient into the external hydrophilic phase and, consequently, its re-crystallization.

The invention provides a naturally occurring strain of Lactobacillus crispatus with advantageous characteristics. The strain colonizes mucosal surfaces, particularly vaginal surfaces. The strain is also capable of rapid growth in a number of conditions and is highly viable after desiccation. Moreover, the strain is capable of preventing and reducing pathogenic infection of vaginal mucosa.

Described is a spray-on hydrogel comprising water-soluble PEG polymers that cross-link in situ to form a hydrogel such that the cross-links are reversible. The hydrogel can be useful as a drug delivery composition, wound dressing or surgery adjuvant. Polyethylene glycol polymer and cross-linker solutions are sprayed simultaneously through a common orifice. Cross-linking via formation of thioether or disulfide bonds is initiated upon mixing, providing rapid gelation. The hydrogel components can be derivatized with RGD peptides or analogs thereof to promote retention in / on a body compartment such as the skin, surface of the eye, or a mucosa such as the vaginal mucosa. The cross-links are reversed using a reducing solution enabling easy removal of the hydrogel by dissolution. Processes for preparation of the cross-linker, RGD derivatized PEG and RGD-linked agents are also disclosed.

Compositions comprising oligosaccharide aldonic acids are useful for general care, as well as for treatment and prevention, of various cosmetic conditions and dermatological disorders, including those associated with intrinsic and / or extrinsic aging, as well as with changes or damage caused by extrinsic factors; general care, as well as treatment and prevention of diseases and conditions, of the oral, and vaginal mucosa; for general oral care, as well as treatment and prevention of oral and gum diseases; and for wound healing of the skin. Compositions comprising oligosaccharide aldonic acids may further comprise a cosmetic, pharmaceutical or other topical agent to enhance or create synergetic effects.

A vaginal device for delivery of an anti-migraine or anti-nausea drug to the uterus and / or to the general circulation through vaginal mucosa. The device is at least partially coated with one or several layers of fluid impermeable material forming a cap, film, foam, foil or strip incorporated with mucoadhesive composition comprising the anti-migraine or anti-nausea drug.

A vaginal device for delivery of an anti-migraine or anti-nausea drug to the uterus and / or to the general circulation through vaginal mucosa. The device is at least partially coated with one or several layers of fluid impermeable material forming a cap, film, foam, foil or strip incorporated with mucoadhesive composition comprising the anti-migraine or anti-nausea drug.

The invention belongs to the technical field of medicines and discloses an itraconazole temperature-sensitive type gel preparation as well as a preparation method and application thereof. The itraconazole temperature-sensitive type gel preparation is composed of the following components in percentage by weight: 0.02-3% of medicines, 0.05-15% of solubilizing agent, 5-50% of gel matrix, 0-15% of biological adhesive, 0.001-2% of preservative, 0-10% of other additives and the balance of solvent. The itraconazole temperature-sensitive type gel preparation can regulate gelatinization temperature by adjusting composition and control drug release rate and degree, can effectively inhibit growth of candida in vitro and can be used for drug administration on skins, eyes, nasal cavity, oral cavity, straight intestine or vaginal mucosa. The itraconazole temperature-sensitive type gel preparation has obvious slow release and biological adhesion property and can prolong action time of medicines on an infection part, realize long-acting treatment, reduce dosage and toxic and side effects and improve patient compliance.

Compositions comprising oligosaccharide aldonic acids are useful for general care, as well as for treatment and prevention, of various cosmetic conditions and dermatological disorders, including those associated with intrinsic and / or extrinsic aging, as well as with changes or damage caused by extrinsic factors; general care, as well as treatment and prevention of diseases and conditions, of the oral, and vaginal mucosa; for general oral care, as well as treatment and prevention of oral and gum diseases; and for wound healing of the skin. Compositions comprising oligosaccharide aldonic acids may further comprise a cosmetic, pharmaceutical or other topical agent to enhance or create synergetic effects.

The present invention relates to applicators for applying powders to the vaginal mucosa.

The invention relates to a medicine, in particular to broad-spectrum and high-efficiency antibacterial washing liquor and a preparation method thereof. The invention is characterized in that the antibacterial washing liquor is prepared by the following materials according to the weight ratio: 0.0001-2.0 of N-coconut-oil fatty-acid acyl L-arginine ethyl ester DL-pyrrolidone carboxylate, 0.0001-1.0 of dodecyl dimethyl benzyl ammonium chloride, 10.0-99.995 of water, and the balance of auxiliary materials. The broad-spectrum and high-efficiency antibacterial washing liquor has the following characteristics and advantages that pathogenic microorganisms are killed in a broad-spectrum and high-efficiency manner; ureaplasma urealytium, gonococcocci and trichomonas vaginalis can be killed in one minute; the killing rate for escherichia coli, staphylococcus aureus and candida albicans is respectively more than 99%; non-toxic; no stimulation is caused to the skin; no allergic reaction is caused; no stimulation is caused to the eyes; no stimulation is caused to vaginal mucosa; and the pH value of a preparation is close to that in the normal vagina.

A vaginal treatment composition that rapidly forms a gel when placed into contact with monovalent or polyvalent cations, such as sodium (Na+) and calcium (Ca2+) cations naturally found in vaginal mucosa, is provided. The gel may form in less than about 1 hour, in some embodiments less than about 1 minute, and in some embodiments, less than about 30 seconds. Among other things, such rapid gelation reduces the likelihood of leakage during use. In addition, because the gel may form intravaginally, it is more likely to retain its structure and shape over an extended period of time. In this manner, the gel may provide the prolonged release of a therapeutic agent that inhibits and / or treats vaginal infection. For instance, the gel may remain within the vagina for about 2 to about 48 hours to provide the desired effect.

A hydrophilic liquid disinfectant for surgical operation, trauma, burn, perineal mucosa, oral mucosa, vaginal mucosa, etc is prepared through adding iodine, chlorhexidine and polyhexamthylene guanidine to non-ionic surfactant, heating, stirring, adding penetrant, phosphoric acid and water, and stirring.

A vaginal treatment composition that rapidly forms a gel when placed into contact with monovalent or polyvalent cations, such as sodium (Na+) and calcium (Ca2+) cations naturally found in vaginal mucosa, is provided. The gel may form in less than about 1 hour, in some embodiments less than about 1 minute, and in some embodiments, less than about 30 seconds. Among other things, such rapid gelation reduces the likelihood of leakage during use. In addition, because the gel may form intravaginally, it is more likely to retain its structure and shape over an extended period of time. In this manner, the gel may provide the prolonged release of a therapeutic agent that inhibits and / or treats vaginal infection. For instance, the gel may remain within the vagina for about 2 to about 48 hours to provide the desired effect.

The invention relates to a bacterium and disease prevention wet wipe liquid medicament and a preparation method thereof. The active ingredients of the wet wipe liquid medicament comprise the following components in part by weight: 0.1 to 5 parts of atractylis oil, 0.01 to 0.5 part of berberine, 0.01 to 0.5 part of eucalyptus oil, 0.01 to 0.05 part of borneol, and 0.01 to 0.5 part of menthol. Experiments show that the wet wipe provided by the invention has bacterium and disease prevention functions, no irritation or side effect to skins and vaginal mucosa, aromatic scent, and better effects than the prior art, and is convenient to carry.

The invention relates to a method for preparing root of ballon flower into the drug that kills sperm externally. The root of ballon flower can kill sperm externally; therefore, the invention makes it into emulsion or bougie. And the production comprises that: breaking root of ballon flower, immerging in 0.9% normal saline at 100g: 900-1200ml, heating in metal bath at 100Deg. C, taking out, filtering, removing slag, to obtain extractive, and treating extractive into emulsion or bougie. The inventive extractive will not stimulate vaginal mucosa, and affect the vaginal bacterial, without side effect. And it can function long time.

The invention relates to the technical field of preparation of colpitis medicines, and especially relates to a vaginal gel and a preparation method thereof in order to solve the technical problem of unsatisfactory bacteriostasis, lubrication and moisture retention effects of existing vaginal gel products. The vaginal gel mainly comprises sodium hyaluronate, vitamin E succinate modified hyaluronic acid, EGF (epidermal growth factors), vitamins C, calcium chloride, pentanediol, glycerin, Rhodicare and a buffer system adopting disodium hydrogen phosphate-citric acid as gel. The vaginal gel has anti-inflammatory activity, improves the wetness of vaginas, is used for treating vaginal inflammatory diseases and alleviating vaginal dryness or used as a human body lubricant, has a vaginal mucosa squamous cell layer restoration promoting effect, can improve vaginal mucosa layer thinning and restore small injuries in vaginas to recover the elasticity and the softness of the vaginal mucosa, and is suitable for colpitis and vagina dryness people.

The invention provides a vagina health probiotic composition. The vagina health probiotic composition comprises lactobacillus plantarum L-137 and at least one female probiotic, wherein the female probiotic is lactobacillus separated from the vagina or the urethra of a healthy female. The inactivated lactobacillus plantarum L-137 has the effect of promoting the growth of probiotics, especially thegrowth of the lactobacillus. The composition disclosed by the invention can recover vaginal flora, so that proliferation of harmful bacteria is inhibited, discomfort such as vaginal pain and itching and dryness can be relieved, peculiar smell is removed, the pH value is balanced, and the immune defense function of vaginal mucosa is enhanced. Vaginitis can be treated in an auxiliary manner; and thevaginitis can be prevented from happening and relapsing.

The invention discloses antibacterial gel for gynecology and a preparation method thereof. The antibacterial gel is prepared from the following raw materials in percentage by weight: 1-5% of cecropinantibacterial peptide, 1-5% of gastrodia elata polypeptide, 1-5% of luteolin, 10-30% of a thickener, 2-6% of a wetting agent, 1-5% of tocopherol, 1-3% of sodium hyaluronate, 0.5-2% of menthol, a proper amount of a pH regulator and the balance of purified water. The antibacterial gel for the gynecology uses cecropin B and gastrodia elata polypeptide as antibacterial peptide active ingredients, which has a synergistic antibacterial effect, and can treat gynecological diseases such as cervical erosion, vaginitis and pelvic inflammation. The antibacterial gel disclosed by the invention is non-irritant to vaginal mucosa cells, high in safety, and excellent in stability and easy to absorb by a human body, and after the gynecological antibacterial gel is used, the skin of the private parts of women can be moisturized, fresh and healthy.

The invention achieves the aims of treating or improving symptoms of hysteroptosis, vaginal relaxation and hyposexuality by means of the principle that small-molecule collagen can be directly absorbed by vaginal mucosa to restore pelvic floor tonicity immediately. Proanthocyanidin in compositions can immediately eliminate free radical to avoid redestruction of connective tissues; moreover, the Chinese medicinal compositions comprise ingredients capable of exciting uterus, providing immunity and playing a role in resisting fatigue, bacteria, viruses and oxidation. The clinic observation shows that collagen and pharmaceutical compositions thereof can quickly improve the symptoms of the vaginal relaxation, the hysteroptosis and the hyposexuality along with lasting action and stable effects; therefore, the collagen and drug compositions thereof are the optimal choices at present to treat and prevent gynaecological diseases such as the hysteroptosis, the vaginal relaxation and the hyposexuality.

The invention relates to the technical field of preparation of medicines for treating vaginitis, particularly relates to a vaginal gel containing multi-effect factors and a preparation method thereof,and solves the technical problems that the antibacterial, lubricating and moisturizing effects of the existing vaginal gel products are not ideal. The vaginal gel contains a conditioned medium extracting solution of mesenchymal stem cells and traditional Chinese medicine extract, can effectively inhibit the propagation of vaginitis-related bacteria and improve the vaginal moistness, is used for treating vaginal inflammation and relieving vaginal dry symptoms or serves as a human body lubricant, simultaneously has the effect of promoting the repair of the squamous epithelial cell layer of thevaginal mucosa, can enable the vaginal mucosa layer to be thinned and repair small injuries in the vagina, can recover the elasticity of the vaginal mucosa and enable the vaginal mucosa to restore elasticity and softness, and is suitable for people suffering from vaginitis and colpoxerosis.

The invention belongs to the field of sanitary napkins and health pads, and in particular relates to a microbial bacteria powder additive for the sanitary napkins and the health pads, and a preparation method of the microbial bacteria powder additive. The microbial bacteria powder additive is prepared from the following components in parts by weight: 1-4% of lactobacillus acidophilus (CGMCC1.1854), 1-4% of enterococcus faecium (CICC6049), 1-4% of lactobacillus delbrueckii (ACCC11017), 1-4% of lactobacillus helveticus (CICC6024), 1-4% of lactobacillus fermentum (CGMCC1.2133), 1-4% of lactobacillus plantarum (CICC1.2158) and 1-4% of lactococcus lactis (ACCC1.2472). The microbial bacteria powder additive is capable of generating lactic acid, maintaining an acid environment, resisting the invasion of pathogenic bacteria such as mould, escherichia coli and staphylococcus aureus by means of mechanisms such as adhesion competition and vaginal mucosa immunity enhancement, and maintaining vaginal microhabitat balance, thus effectively preventing and treating vagina inflammatory diseases.

The invention discloses a disinfecting and sterilizing fomulation for vaginal mucosa, which comprises Cydiodini, diluent, crumbling agent, acid forming agent, and binding agent. The invention can be applied for effectively eradicate various microorganisms with stable physical and chemical property but no irritating action.

The invention relates to an antibacterial paper towel and a preparation method thereof, and discloses a process for papermaking by using Qianjinfang medicine residue, wherein the process comprises: microwave pretreatment, fermentation, washing, paper making, extracting of medicinal ingredients from waste liquid, paper modification and the like. According to the present invention, the short fiber is prepared by using the Qianjinfang medicine residue, and the long fiber property of the cotton fiber is combined, such that the prepared antibacterial paper towel has good tensile property; the prepared antibacterial paper towel has remarkable wet strength through internal sizing and surface application; by using the microwave radiation method and the biological method, harmful chemicals are notintroduced during the whole process, such that the hygienic characteristics of the paper are ensured; and the medicinal ingredients are extracted from the pulping waste liquid, and are mixed with thebase medicine liquid component comprising Cortex Ailanthi, Sophora flavescens Ait, Cortex Moutan, frankincense and borneol, and the obtained mixture is applied on the paper, such that the obtained antibacterial paper towel has good anti-inflammatory and antibacterial effects, can prevent microbial infection, does not have irritation and side effects on the skin and vaginal mucosa, and is suitablefor women.

The invention relates to a method for using polygala root to kill sperm externally, wherein it uses polygala root as the drug to kill sperm externally, makes extractive into emulsion or suppositorium, to be used in vagina contraceptive. And its production comprises that: breaking polygala root, immerges in 0.9% normal saline, while their ration is 100g:900-1200ml, to be heated in 100Deg. C metal bath; taking out, filtering out the slag. The inventive polygala root extractive has non stimulation on vaginal mucosa, without damage on vaginal bacterial and side effect. And it has low cost.