64 results about "Vaginal mucosa" patented technology

The present invention relates to a device for the prevention and / or treatment of fecal and / or urinary incontinence. The device may fit into a vagina. The device may include a pressure sensor and electrodes. The device may include a lateral projection on the device and / or a skin of the device. In response to intra-abdominal pressure the device may apply electrostimulation with the electrodes, for example to a vaginal mucosa.

According to the vaginal mucosa repairing composition containing the rose component and the application, the vaginal mucosa repairing composition achieves multiple effects of inhibiting pathogens, relieving inflammation and repairing mucosa through the synergistic effect of the LGG fermentation product and the rose component. According to the in-vitro verification method based on the vaginal mucosa epithelial cell 3D model, an in-vivo multi-layer mucosa structure and a complex microenvironment are accurately simulated, the barrier function, inflammation regulation and control and cell proliferation capacity of the vaginal mucosa repair composition are accurately evaluated, and the mucosa barrier function and multi-cell interaction are reflected.

The invention discloses a lactobacillus acidophilus FMM01 with the effects of improving the contractility of pelvic floor muscles and repairing mucous membranes and application of the lactobacillus acidophilus FMM01, the lactobacillus acidophilus FMM01 is preserved in the China Center for Type Culture Collection, the preservation date is January 9, 2024, and the preservation number is CCTCC NO: M2024052. The lactobacillus acidophilus FMM01 has the advantages of self-adaption, high acid resistance, strong mucous membrane adhesiveness and no irritation to vaginal mucosa. The lyophilized powder is high in activity and excellent in stability; experimental results show that the lactobacillus acidophilus FMM01 can effectively inhibit bacteria, and especially can effectively inhibit enterobacter cloacae, vibrio parahaemolyticus and / or candida albicans. Besides, the lactobacillus acidophilus FMM01 can improve vaginal relaxation, improve pelvic floor muscle contractility and / or recover vaginal mucosa functions, can promote recovery of healthy florae after mixed vaginitis antibiotic / hormone treatment, improves the treatment effect of mixed vaginitis, and remarkably reduces the recurrence rate of mixed vaginitis.

The present invention provides a carbomer copper gluconate complex hydrogel, a preparation method, and applications thereof. The carbomer copper gluconate complex hydrogel is prepared in 100 ml or 100 g portions. The raw materials, calculated by mass percentage, include: 0.01% to 0.1% carbomer copper gluconate complex (calculated as copper ion addition); 1% to 2% propylene glycol; 0.1% to 0.2% sodium hyaluronate; 2% to 6% dimethicone; and the balance is an acidity regulator and water. The carbomer copper gluconate complex hydrogel not only effectively kills sperm and common pathogens, but also protects the vaginal mucosa while providing contraception, avoiding the irritation and side effects of chemical spermicides.

The present application belongs to the technical field of daily chemical preparation, and particularly relates to a gynecological gel for inhibiting bacteria, regulating microecological balance and tightening vagina and a preparation method thereof. The gynecological gel comprises the following raw materials in mass fractions: 0.5-1 parts of carbomer, 0.04-0.09 parts of sodium hydroxide, 1-3 parts of collagen, 0.01-0.06 parts of sodium hyaluronate, 0.5-1.5 parts of isomaltooligosaccharide, 2-5 parts of propylene glycol, 0.05-0.3 parts of hydroxybenzoic acid methyl ester, 0.02-0.15 parts of hydroxyphenyl ethyl ester, 0.1-1.5 parts of hydrogenated lecithin, 1-6 parts of 1,3-butanediol, 3-5 parts of glycerol, 0.5-1 part of xanthan gum and 70-90 parts of water. The present application uses buckwheat filtrate to prepare collagen, and the active ingredients in the buckwheat filtrate can penetrate the cell membrane of pathogenic bacteria to play an antibacterial role; the collagen can repair the vaginal mucosa barrier and reduce the adhesion and invasion of pathogenic bacteria; therefore, after being compounded with the raw materials such as carbomer, sodium hydroxide, sodium hyaluronate, isomaltooligosaccharide and propylene glycol, the multiple components can synergistically promote the synthesis and repair of collagen fibers and improve the elasticity of tissues.

The invention relates to the field of prevention and treatment of vaginitis, in particular to a composition of lactobacillus rhamnosus LRa05, lactobacillus acidophilus La88 and lactobacillus plantarum Lp90 and application of the composition to regulation of vaginal mucosa barrier protein. The lactobacillus rhamnosus LRa05 is a lactobacillus rhamnosus LRa05 with the preservation number of CGMCC (China General Microbiological Culture Collection Center) NO.24377, and the lactobacillus rhamnosus LRa05 is a lactobacillus rhamnosus LRa05 with the preservation number of CGMCC NO.24377. The lactobacillus acidophilus La88 is the lactobacillus acidophilus La88 of which the preservation number is CGMCC (China General Microbiological Culture Collection Center) NO.24109, and the lactobacillus acidophilus La88 is a lactobacillus acidophilus La88 of which the preservation number is CGMCC NO.24109. The lactobacillus plantarum Lp90 is the lactobacillus plantarum Lp90 with the preservation number of CGMCC (China General Microbiological Culture Collection Center) NO.10453, and the lactobacillus plantarum Lp90 has the preservation number of CGMCC NO.10453. The lactobacillus rhamnosus LRa05, the lactobacillus acidophilus La88, the lactobacillus plantarum Lp90 and the combination thereof disclosed by the invention can regulate the expression of the vagina mucosal barrier protein.

The invention relates to an antibacterial gel and a preparation method thereof. The gel mainly comprises silver ions, avocado oil, a radix puerariae extract, wheat germ oil, emulsifying wax, a folium artemisiae argyi extract, glycerol, a styrene / butadiene copolymer, purified water and hydroxyethyl cellulose. Extracts containing specific small-molecule polypeptides are extracted from Artemisia rubescens and Radix Puerariae through a specific extraction method, and the polypeptides are Artemisia rubescens polypeptides (SEQ ID No: 1) and Radix Puerariae polypeptides (SEQ ID No: 2) respectively. The extracts have a synergistic effect with silver ions, so that the antibacterial effect of the gel is remarkably improved, and particularly, the gel has a remarkable inhibiting effect on staphylococcus aureus, escherichia coli and candida albicans. The bacteriostatic gel is simple in preparation method, convenient to use and suitable for bacteriostasis of female vaginal mucosa and maintenance of vaginal micro-ecological internal environment.

The application discloses a human vagina micro-ecological in-vitro model and a construction method and application thereof, and relates to the technical field of medicines.The application discloses a human vagina micro-ecological in-vitro model and a construction method and application thereof.Firstly, a mixed cell group of the vaginal epithelium containing a complete cell lineage and capable of long-term subculture is successfully established, a technical bottleneck that primary vaginal epithelial cells are difficult to expand is solved, and ideal seed cells are provided for model construction.Secondly, a highly-bionic vaginal mucosa model having a tight connection structure, rich layers and an orderly arrangement is constructed, and the physiological barrier and immune regulation functions of the vaginal mucosa are truly simulated.Finally, by introducing lactobacillus symbiosis and confirming the response to estrogen, a multi-element in-vitro research model integrating the anatomical structure of the vagina, resident flora, local immunity and endocrine regulation is constructed, and a reliable technical platform is provided for in-depth exploration of the mechanism of vaginal micro-ecological disorder and efficient screening of related drugs.

The invention discloses a female vaginal mucosa cell maintenance preparation and a preparation method and application thereof, and belongs to the technical field of biological agents, the female vaginal mucosa cell maintenance preparation is prepared from dental pulp mesenchymal stem cells, portulaca oleracea polysaccharide, lactic acid, quercitrin, glycerin and stem cell carriers, and vaginal injection paste is obtained by evenly mixing the dental pulp mesenchymal stem cells, the portulaca oleracea polysaccharide, the lactic acid, the quercitrin, the glycerin and the stem cell carriers through a proper amount of deionized water. The purslane polysaccharide and the dental pulp mesenchymal stem cells form a unique synergistic effect, through physical wrapping, the survival rate and delivery efficiency of the stem cells in a vaginal cavity are improved, local inflammatory response is inhibited, a microenvironment is optimized to support directional differentiation of the stem cells into epithelial cells, paracrine activity of the stem cells is enhanced, and repairable factors are released to promote cell-level regeneration. The problem of hormone dependence is solved, deep maintenance of targeted mucous membrane cells is achieved, limitation of an existing therapy is broken through by directly nourishing cells, activating and regenerating, enhancing barrier integrity and maintaining an acidic microenvironment, and an ideal treatment effect is achieved.

The invention discloses a composition of type III collagen and beta-glucan and application of the composition in repairing vaginal mucosa injury, and belongs to the technical field of biological medicine, and the composition comprises the following effective components: type III collagen with the concentration of 0.3-1.8 mg / mL and beta-glucan with the mass concentration of 0.1-0.8%. The collagen III provides structural support required by tissue repair, the beta-glucan improves inflammation microenvironment, regulates immune response and jointly promotes proliferation and migration of damaged vaginal epithelial cells, the cell proliferation rate and the scratch healing rate are far higher than those of a group using any component independently, and rapid repair of mucosal lesions can be achieved.

The invention belongs to the technical field of gel preparation, and particularly relates to mussel mucoprotein physical barrier protective gel and a preparation method thereof. The mussel mucin polymer disclosed by the invention can quickly form a compact and flexible isolating membrane with self-repairing capability on the surface of vaginal mucosa. The isolating membrane can be firmly attached to the surface of a mucous membrane based on the strong biological adhesiveness of mussel mucin, can directly block sperm penetration and limit sperm swimming, and also can effectively block pathogenic microorganisms such as viruses and bacteria from contacting the mucous membrane. The acid environment provided by the lactic acid-citric acid buffer system not only can directly inhibit sperm activity, but also can enhance the stability and adhesiveness of the mussel mucin polymer, so that the mussel mucin polymer can be better attached to vaginal mucosa, and the action time of a physical barrier is prolonged. The chitosan quaternary ammonium salt has the effects of killing bacteria and viruses and the like, and the hydroxypropyl methyl cellulose serving as a thickening agent can improve the viscosity and the stability of the gel, so that the gel can be better retained in the vagina, and the action time is prolonged.

Methods of treating a patient suffering from one or more of epidermal disorders of persistent inflammation—cell kinetics and differentiation disorders, epidermal disorders of persistent inflammation—altered reactivity disorders, disorders of the lips, oral, or vaginal mucosa, epidermal disorders of cohesion—vesicular and bullous disorders, cutaneous lymphomas, skin manifestations of rheumatologic diseases, hypomelanoses and hypermelanoses, or skin manifestations related to oncology treatments. The methods include topical administration of a pharmaceutical composition comprising a therapeutically effective amount of roflumilast.

The present invention discloses a gynecological irrigator, which includes an extrusion structure, a turbine structure and a rotating structure. The output end of the extrusion structure is connected to the input end of the turbine structure through a first hose, and the output end of the turbine structure is connected to the input end of the rotating structure through a second hose. Cleaning liquid is stored in the inner cavity of the extrusion structure and is squeezed through the first hose into the interior of the turbine structure. The water flow impulse input through the first hose causes the interior of the turbine structure to rotate and drives the rotating structure to rotate. The output end of the turbine structure causes the cleaning liquid to enter the inner cavity of the rotating structure through the second hose due to the extrusion force, causing the rotating structure to rotate to achieve uniform flushing. The uniform flushing method and adjustable flushing force reduce the possibility of damage to the vaginal mucosa due to excessive flushing force or uneven flushing. This irrigator can better protect the vaginal mucosa while ensuring the flushing effect, thereby improving the safety of use.

The invention provides temperature-sensitive poloxamer gel for preventing vaginal radiation injury and a preparation method of the temperature-sensitive poloxamer gel, and belongs to the technical field of medical gel. The temperature-sensitive type poloxamer gel is prepared from the following components: 6 percent to 18 percent of a poloxamer compound, 3 percent to 8 percent of a functional component, 0.01 percent to 0.08 percent of a penetration enhancer, 0.10 percent to 0.45 percent of a regulator, 0.13 percent to 0.25 percent of a humectant, 0.05 percent to 0.12 percent of a preservative and the balance of water, the poloxamer compound is prepared by compounding poloxamer 407 and poloxamer 188, and the poloxamer compound is prepared by compounding the poloxamer 407 and the poloxamer 188. The temperature-sensitive poloxamer gel for preventing the vaginal radiation injury, disclosed by the invention, is relatively long in retention time at an acting part, has a certain slow release effect, can keep long-time stimulation to vaginal mucosa, is beneficial to rapid healing of a wound surface, can effectively prevent radioactive vaginitis, is convenient to use, and is safe and non-irritant to a human body.

The invention provides a vaginal packing with an antibacterial function and a preparation method and application thereof, and relates to the technical field of vaginal packing, the vaginal packing with the antibacterial function comprises dihydroquercetin, citric acid, galactooligosaccharide, isomaltooligosaccharide, sodium lactate, sodium hyaluronate and chitosan. The dihydroquercetin has a relatively strong antibacterial function; the permeation enhancer chitosan can prolong the residence time of the dihydroquercetin at the absorption part, improve the local concentration gradient and promote the vaginal mucosa to absorb the dihydroquercetin; sodium hyaluronate can improve the solubility and stability of dihydroquercetin, enhance the absorption efficiency of dihydroquercetin, further improve the antibacterial performance, control the release progress, realize slow release, accelerate the permeation of water into the interior and enhance the vaginal filling and imbibition speed. The isomaltooligosacharide and the sodium lactate can be mixed with the chitosan to form an adsorption material which is used for absorbing secretions, providing prebiotics support and adjusting the pH value.

The invention belongs to the technical field of biological medicine, and relates to an adjustable vaginal mucosa targeted delivery method based on bidirectional osmotic pressure difference control, which comprises the following steps: placing a preset complete drug delivery device into a vagina, and enabling a soluble osmotic active substance in a peripheral structure to be in contact with vaginal body fluid to form a local high-concentration salt solution area; generating a continuously inward body fluid permeate flow; forming a medicine-containing mixed solution; establishing a directional driving force for conveying the medicine-containing mixed solution to the vaginal mucosa; the intensity of body fluid permeation flow is adjusted, and the moving speed of the medicine to the mucosa interface is controlled; when the drug release is completed or the preset treatment duration is reached, the complete drug delivery device is removed from the vagina; through directional pushing force, directional enrichment of the medicine-containing mixed solution on the vagina mucosa surface layer is achieved, and a medicine enrichment zone is formed. The problem that a dosage form or a device cannot realize real-time regulation and control of the release rate is solved.

The present invention describes a composition for vaginal, preferably intravaginal, use for the prevention and treatment of vaginal conditions, with mucoadhesive, soothing, moisturizing and pH-regulating properties. By remaining adherent to the vaginal mucosa for prolonged periods, the composition according to the invention is therefore able to alleviate pain, burning and itching, often resulting from vaginal dryness, to promote the rebalancing of the vaginal bacterial flora, to restore the natural pH, to combat vaginal atrophy, vaginosis, vaginitis, to reduce local irritation of the tissues and to combat the proliferation of pathogens.

The invention discloses a method for tightening a vagina by using a biological band, which comprises the following steps: S1, preparing the biological band which is made of decellularized allogeneic dermis and mainly comprises elastin, fibronectin, hyaluronic acid, I-type collagen, III-type collagen, IV-type collagen and VII-type collagen; s2, the biological bridle is in a strip shape of a 3D structure, the specification of the biological bridle is 1 * 15 cm, and in the using process, the biological bridle is cut into different lengths according to using requirements. The problems that in a traditional vaginal contraction operation, part of vaginal mucosa or muscular layer needs to be cut off through an incision, and suturing and tightening are conducted, so that tissue damage is large, postoperative pain is obvious, the recovery period is long, mucosa nerve damage, sexual sensitivity reduction, scar formation and the like are likely to occur after operation, and the vaginal function and life quality are affected are solved.

The invention relates to the technical field of medical treatment, in particular to herbal gynecological inflammation clear water gel, which is prepared from the following components in percentage by mass: 14 percent of traditional Chinese medicine extracting solution, 47.5 percent of matrix and 38.5 percent of matrix, the matrix 1 is N, O-carboxymethylated chitosan, and the matrix 2 is L-leucine. The hydrogel preparation adopted by the invention can be tightly attached to the surface of a vaginal mucosa by virtue of a specific three-dimensional network structure and good elasticity, so that more uniform coating and more lasting retention are realized, the loss of medicinal components caused by the self-cleaning effect of the vagina is reduced, and the effect that the medicine can continuously act on an inflammation part is ensured; the hydrogel prepared by the method is soft in texture, high in biocompatibility, almost free of irritation and foreign body sensation after being used and smoother and milder in administration process, and the comfortable use experience is beneficial to relieving psychological burdens of patients and enhancing trust and cooperation of the patients with treatment schemes.

The invention relates to the technical field of human body lubricants, and particularly discloses a condom bubble lubricant containing hyaluronic acid and a preparation method of the condom bubble lubricant. The condom bubble lubricant containing hyaluronic acid is prepared from the following raw materials in parts by mass: 5 to 10 parts of hyaluronic acid, 1 to 3 parts of sodium alginate, 0.01 to 0.1 part of calcium ethylene diamine tetraacetate, 1 to 2 parts of nano silicon dioxide, 1 to 2 parts of surfactant, 60 to 120 parts of vegetable oil, 1 to 2 parts of citric acid, 1 to 2 parts of green tea extract, 1 to 2 parts of glutathione, 5 to 10 parts of plant essential oil, 1 to 3 parts of dialdehyde cellulose and 50 to 90 parts of water. According to the invention, the vagina can be effectively protected, the vagina mucosa can be effectively repaired, the immunoreaction can be effectively reduced, the good inhibition effect on common pathogenic bacteria is realized, the biocompatibility of the components and the human skin is high, the micro-ecological environment of the cavity is improved, the allergy and stimulation effects are avoided, the raw materials are easy to obtain, the operation is easy, and the reaction conditions are mild.

The present invention discloses an anti-HPVHIV human body lubricating liquid, and relates to the technical field of biological medicine, the anti-HPVHIV human body lubricating liquid is prepared from the following raw materials by weight: 0.1-20 parts of sodium hyaluronate with a molecular weight of 10,000-25,000 Da; 20 to 99 parts of purified water; 0.01 to 10 parts of sodium dihydrogen phosphate; 1 to 10 parts of water; 0.1 to 20 parts of glycerol; 0.01 to 10 parts of a surfactant; the surfactant is one or more of betaine, lauryl sodium sulfate and Tween 80, and the molecular weight of the sodium hyaluronate is 0.5 million to 1.5 million Da. The anti-HPVHIV human body lubricating liquid has dual effects, on one hand, a physical membrane is formed through sodium hyaluronate, and HPV viruses and HIV viruses are prevented from infiltrating host cells of a vaginal mucosa base layer;

The invention provides a gel preparation, the gel preparation comprises a reverse-phase temperature-sensitive hydrogel matrix and bioactive vesicles, and the reverse-phase temperature-sensitive hydrogel matrix comprises a water-soluble matrix material and a reverse-phase temperature-sensitive material. The gel preparation disclosed by the invention can be used for regulating local immune response at a radioactive vaginal mucosa injury part, reducing secretion of inflammatory factors, repairing non-target cell DNA injury caused by radiotherapy and efficiently promoting recovery of the radioactive vaginal mucosa injury, so that an efficient and safe radioactive vaginal mucosa injury treatment strategy is provided for clinical application; the clinical problems that the radioactive vaginal mucosa injury is low in cure rate, easy to relapse and the like are fundamentally solved.

The patent discloses a kind of vaginal injection devices, it is related to medical injection field, device includes base and expansion board, expansion board can slide along the sliding slot on base, reach the function of vaginal speculum by the expansion of expansion board, make expansion board adhere to vaginal mucosa;Base has handle for fixing entire injection device;Expansion board has several needle holes, injection needle can be worn from needle hole and carry out drug injection;Needle and medicine bin are connected, medicine bin and needle are closed space, fill the medicine needed to be injected in;The length of needle that entire medicine bin is adjusted to be worn needle hole is adjusted by the movement of gear and gear sliding slot, the depth of drug injection into vaginal mucosa;The new type of patent does not need to use vaginal speculum to assist injection in vagina during use process, can accurately control the depth of drug injection, complete the injection of entire vaginal mucosa once, shorten operation time, improve injection efficiency, reduce drug waste, improve curative effect, reduce patient pain.

The application discloses a lactobacillus gasseri for repairing a vaginal barrier and relieving a vaginal infection, and a postbiotic thereof, and belongs to the technical field of microorganisms.The lactobacillus gasseri and the postbiotic thereof can repair a vaginal barrier and relieve a vaginal infection when being used externally.The lactobacillus gasseri is separated from vaginal secretion of a healthy female, has the functions of repairing a vaginal mucosa barrier and relieving a vaginal infection, and specifically has the following effects: improving a cell monolayer barrier transendothelial electrical resistance value, increasing integrity, reducing FITC-labeled dextran permeability of the cell monolayer barrier, and reducing permeability;adjusting a mouse vaginal mucin level;improving a mouse vaginal tissue protein expression level;reducing mouse vaginal tissue IL-1 beta secretion and myeloperoxidase content;and improving a mouse vaginal tissue pathological condition.Therefore, the lactobacillus gasseri has great application prospects in products for repairing a vaginal mucosa barrier and relieving a vaginal infection caused by pathogenic bacteria.

This invention discloses a compound preparation of plant-fermented lactic acid bacteria lysate for nourishing and protecting the vaginal pelvic floor muscles. By weight, it comprises the following components: kidney bean-honeysuckle fruit compound ferment: 4-8 parts; pomegranate peel-derived lactic acid bacteria lysate: 5-9 parts; bamboo fungus mycelium extract: 3-7 parts; compound sophorolipid: 6-8 parts; sodium hyaluronate: 2-5 parts; total glycosides of Centella asiatica: 1-3 parts; glycerin: 5-10 parts; lactic acid: 1-2 parts; purified... Water: 36-45 parts; Carbomer 940: 2-4 parts; Trehalose: 1-3 parts; Chitosan: 1-3 parts; Methylchloroisothiazolinone: 0.1-0.3 parts; Sodium hydroxide: 0.1-0.2 parts; This invention can regulate the vaginal microecological balance, nourish the vaginal mucosa, enhance the toughness of pelvic floor muscle fibers, and promote the repair of pelvic floor muscle damage, solving the technical problems of existing preparations having single function, weak targeted pelvic floor muscle care, and easy disruption of the vaginal microecology.

The invention discloses a condom added with a nanoscale inactivated probiotic lubricant and a preparation method of the condom, and belongs to the technical field of condom production. The core of the method is that medicinal solid inactivated probiotics are crushed into particles with D90 of 10-100 nanometers through supersonic airflow, then the particles are uniformly dispersed in a condom lubricant, the particles are emulsified and sheared and then added into a condom within 48 hours, and the condom added with the nanoscale inactivated probiotic lubricant is prepared. The method effectively solves the technical problems of low survival rate and poor stability of the active probiotics in the lubricant. The obtained product can realize uniform distribution of inactivated probiotics in the use process, efficiently regulates flora balance through interaction of thallus fragments and vaginal mucosa, and has the remarkable advantages of stable effect and long storage period.

This invention discloses a gynecological antibacterial hydrogel, its preparation method, and its application. The hydrogel comprises a water extract of traditional Chinese medicines including Verbena officinalis, Salvia miltiorrhiza, Portulaca oleracea, Sophora flavescens, Viola yedoensis, Phellodendron chinense, and Artemisia argyi, as well as lactic acid, chitosan, and water. The preparation involves a water extraction and alcohol precipitation purification process to obtain the herbal extract, which is then mixed with a chitosan-lactic acid swelling matrix, adjusted to pH 3.8-4.4, and then filled and sterilized. Based on the principles of traditional Chinese medicine (TCM) formulation and combined with modern pharmaceutical technology, this invention's gel possesses the effects of clearing heat and drying dampness, detoxifying and killing parasites, and promoting blood circulation and removing blood stasis. It exhibits strong inhibitory activity against common gynecological pathogens, restores the acidic environment of the vagina, regulates local immunity and microenvironment, has an adjunctive therapeutic effect on HPV infection, is non-irritating to the vaginal mucosa, and has high safety and good stability.

The invention relates to the technical field of medicine, in particular to a vagina tightening bacteriostatic preparation and a preparation method thereof.The vagina tightening bacteriostatic preparation is prepared from, by mass, 0%-0.5% of carbomer, 5%-13% of galactomannan, 1%-6% of transient pink regulator, 0.1% of tetrahydropiperine, 4% of physalis alkekengi extracting solution and 10% of composite plant fungicide; the amount of the neutralizer is the amount which enables the pH value of the preparation to be 6.0-6.5. According to the invention, the galactomannan instantly forms a film to tighten and shrink vagina, the instant plicatin rapidly thickens vagina mucosa, the plant penetrant tetrahydropiperine promotes permeation of effective components and increases the mucosa absorbance of the effective components, so that the vagina shrinking effect is multiplied, and the plant penetrant tetrahydropiperine cooperates with other various components to achieve a synergistic effect, so that the vagina shrinking effect is improved. And a rapid and efficient vagina contracting effect is achieved.