Mussel mucoprotein physical barrier protective gel and preparation method thereof

By using a gel composed of mussel adhesive protein polymers and chitosan quaternary ammonium salts, a tight isolation membrane is formed, which solves the problem that existing protective methods cannot effectively block sperm and viruses, and achieves highly efficient protection of the vagina and maintenance of the microecological balance.

CN121287604APending Publication Date: 2026-01-09HENAN YIWEIYI IND CO LTD
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Patent Information

Application Number
CN202511513529.8
Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Filing Date
2025-10-22
Publication Date
2026-01-09

AI Technical Summary

Technical Problem

Existing protective measures are ineffective in blocking sperm and viruses. Traditional physical barriers are inconvenient to use, and chemical spermicides are highly irritating and disrupt the microecological balance, making it impossible to simultaneously prevent unintended pregnancy and the spread of sexually transmitted diseases.

Method used

A gel composed of mussel adhesive protein polymer, chitosan quaternary ammonium salt, hydroxypropyl methylcellulose, etc., forms a tight isolation membrane through dynamic Schiff base bonds and covalent cross-linking network. Combined with a lactic acid-citric acid buffer system to maintain an acidic environment, it enhances adhesion and stability, and blocks sperm and viruses.

Benefits of technology

It forms a tight, flexible, and self-repairing barrier on the vaginal surface, effectively blocking sperm and viruses, limiting pathogen colonization, prolonging the duration of action, and improving user compliance and safety.

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Abstract

The invention belongs to the technical field of gel preparation, and particularly relates to mussel mucoprotein physical barrier protective gel and a preparation method thereof. The mussel mucin polymer disclosed by the invention can quickly form a compact and flexible isolating membrane with self-repairing capability on the surface of vaginal mucosa. The isolating membrane can be firmly attached to the surface of a mucous membrane based on the strong biological adhesiveness of mussel mucin, can directly block sperm penetration and limit sperm swimming, and also can effectively block pathogenic microorganisms such as viruses and bacteria from contacting the mucous membrane. The acid environment provided by the lactic acid-citric acid buffer system not only can directly inhibit sperm activity, but also can enhance the stability and adhesiveness of the mussel mucin polymer, so that the mussel mucin polymer can be better attached to vaginal mucosa, and the action time of a physical barrier is prolonged. The chitosan quaternary ammonium salt has the effects of killing bacteria and viruses and the like, and the hydroxypropyl methyl cellulose serving as a thickening agent can improve the viscosity and the stability of the gel, so that the gel can be better retained in the vagina, and the action time is prolonged.
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