197 results about "Oral ulcers" patented technology

The invention discloses an active polypeptide Tigerin-OL1 capable of promoting healing of oral ulcer and application of the active polypeptide Tigerin-OL1. The active polypeptide Tigerin-OL1 capable of promoting healing of the oral ulcer has an amino acid sequence ICTMIPISRCY as shown in SEQ ID No.1 (sequence identifier number 1). The application of the polypeptide Tigerin-OL1 is the application of the polypeptide Tigerin-OL1 in preparation of drugs for promoting healing of oral ulcer. The polypeptide Tigerin-OL1 provided by the invention has excellent oral ulcer healing promoting activity in vivo and in vitro, only contains 11 amino acids and is easy to synthesize, and a new way is provided for development of drugs for promoting oral ulcer healing.

The invention discloses a double-crosslinking network hydrogel film for treating oral ulcer, a preparation method and application, and relates to the technical field of biomedical materials. According to the hydrogel film, a dual-network synergistic enhancement structure is constructed through covalent / non-covalent bi-crosslinking, the adhesion to oral mucosa is remarkably enhanced by adopting dopamine (DA) modified hyaluronic acid (HA), and the mechanical property is greatly improved by utilizing a bi-crosslinking network system of disulfide bond / double bond crosslinking (chitosan and CS) and hydrogen bond / catechol self-crosslinking (hyaluronic acid and HA); the antioxidant and anti-inflammatory characteristics of lipoic acid (LA) and the natural antibacterial property of chitosan (CS) are combined to play a synergistic effect, so that the antibacterial and anti-inflammatory effects are remarkably improved. Meanwhile, multifunctional modified materials such as metacrylic acid ester are introduced, so that the functionality and the application range of the hydrogel film are expanded. The preparation technology is optimized, it is ensured that the material is safe and effective, large-scale production is easy, and an efficient and reliable novel material is provided for oral ulcer treatment.

The invention provides a hydrogel microneedle patch for treating oral ulcer and a preparation method, and belongs to the technical field of biomedical engineering. The technical problems that in the traditional oral ulcer administration process, medicine is difficult to retain at the focus for a long time, is easily scoured by saliva and is influenced by tongue and cheek movement are solved. According to the technical scheme, the method comprises the following steps: 1) designing and preparing a microneedle patch mold; (2) synthesizing drug-loaded polydopamine nano particles; (3) preparing a microneedle patch; and 4) evaluating the performance of the microneedle patch. The invention has the following beneficial effects: on one hand, the combination of the drug-loaded nanoparticles and the hydrogel microneedle array can reduce the dosage through drug sustained release; and on the other hand, the problems of high drug instability, low targeting property, poor bioavailability and hindering treatment effect are effectively solved, and the preparation can be widely applied to the fields of drug sustained release, wound healing, tissue engineering and the like.

The invention provides a composition for preventing and treating oral ulcer and halitosis and a preparation method of the composition. The composition is prepared from the following raw materials in parts by weight: osmanthus fragrans leaching liquor, fresh rehmannia root leaching liquor, lactobacillus fermentation liquor, carbomer homopolymer A, polysorbate and auxiliary materials. The fresh rehmannia root is subjected to microbial fermentation, the content of effective substances is measured, and the composition for preventing and treating the oral ulcer and the halitosis prepared by the method is simple in component, safe and non-irritating to the oral cavity, has the application effects of efficiently resisting bacteria and removing the halitosis, can meet the requirements of people needing the composition, and has a good market prospect.

The invention discloses a long-time strong-adhesion tissue repair patch and a preparation method thereof, and the preparation method comprises the following steps: adding an adhesion component, an anti-swelling component and alpha-ketoglutaric acid into a colloidal aqueous solution of a patch matrix material to obtain a precursor solution; and pouring the precursor solution into a patch mold, carrying out ultraviolet curing, and drying the obtained gel to obtain the patch. From the selection of materials and chemical bonds, physical and chemical bonds such as amido bonds, disulfide bonds and catechol groups are combined, so that the adhesion strength is improved, the adhesion duration is prolonged, and the adhesive has excellent anti-swelling performance and mechanical performance, can effectively isolate external saliva, food residues and the like when being applied to the oral cavity, reduces infection of ulcer wounds, and has a good application prospect. The dental ulcer healing is accelerated, and the method also has a relatively good application prospect in the field of tissue repair.

The invention discloses a propolis extract-loaded sprayable bifunctional gel as well as a preparation method and application thereof. The preparation method comprises the following steps: synthesizing acetylated carboxymethyl chitosan by taking carboxymethyl chitosan and acetic anhydride as raw materials; the preparation method comprises the following steps: reacting acetylated carboxymethyl chitosan and aminophenylboronic acid serving as raw materials to synthesize a boric acid modified acetylated carboxymethyl chitosan gel precursor; the preparation method comprises the following steps: blending a boric acid modified acetylated carboxymethyl chitosan gel precursor with water, and self-assembling into A-CC-PBA hydrogel under the action of a hydrogen bond and a pi-pi bond; and adding the propolis extract into the A-CC-PBA hydrogel, so as to obtain the A-CC-PBA hydrogel. The gel prepared by the invention has good adhesion performance, can stably retain in the local part of the oral ulcer and can realize efficient targeted recognition and slow release of drugs to realize efficient sterilization and long-acting anti-inflammatory effects, the curative effect on the oral ulcer is obviously improved, and a new preparation type is provided for oral mucosa administration.

The invention relates to the technical field of microorganisms, in particular to plant lactobacillus BR32 with functions of preventing decayed teeth and improving inflammation and application of the plant lactobacillus BR32. The plant lactobacillus BR32 with the functions of preventing decayed teeth and improving inflammation, provided by the invention, has the preservation number of CGMCC No.32836, has an inhibiting effect on the growth of oral pathogens such as streptococcus mutans, candida albicans and porphyromonas gingivalis, is high in oxidation resistance, is beneficial to continuous oral cavity stability maintenance through a synergistic effect, also has relatively high hydrophobicity and self-agglutination capability, and can be used for preparing oral cavity health-care products. The compound is low in tooth environment corrosion, high in lysozyme tolerance and good in oral colonization capacity, does not have a hemolysis phenomenon in in-vitro hemolysis culture, is sensitive to common antibiotics and has relatively high food safety. The invention further provides a microbial agent, a probiotic product, a functional food, a fermented product, a bacteriostatic agent and an oral product containing the plant lactobacillus BR32 with the functions of preventing the decayed teeth and improving the inflammation, and the effects of preventing the decayed teeth, improving the inflammation, preventing dental plaque, relieving oral ulcer and the like are achieved.

The invention relates to the technical field of biological medicines, and provides a pharmaceutical composition for treating liver cancer, which is prepared from the following raw material medicines in parts by weight: 3 to 8 parts of radix paeoniae rubra, 1 to 3 parts of fructus sophorae, 3 to 10 parts of rhizoma polygoni cuspidati, 3 to 20 parts of spica prunellae, 3 to 20 parts of herba hedyotidis diffusae, 3 to 10 parts of herba violae, 2 to 5 parts of turtle shell, 1 to 5 parts of radix angelicae sinensis, 1 to 3 parts of rhizoma curcumae, 1 to 3 parts of apios fortunei maxim and 3 to 5 parts of fructus polygoni orientalis. According to the technical scheme, the problems that in the prior art, after radiotherapy and chemotherapy are conducted on patients, obvious side effects can be generated, such as the symptoms of inappetence, nausea and vomiting, diarrhea, stomachache, dental ulcer and the like, and some patients have the symptoms of listlessness, weakness, shortness of breath, alopecia and the like are solved.

The present invention provides Lactobacillus casei ( Lacticaseibacillus casei ) Application of GG002 and its bacteriocin solution, lyophilized powder and postbiotics in treating oral ulcers, belonging to the field of microbial technology. The present invention finds that Lactobacillus casei GG002 can inhibit Streptococcus mutans, Fusobacterium nucleatum and Porphyromonas gingivalis, and has the effect of treating oral ulcers. The present invention further provides a bacteriocin solution, lyophilized powder and postbiotics of Lactobacillus casei GG002, which can effectively treat oral ulcers.

The present application belongs to the technical field of traditional Chinese medicine, and particularly relates to a traditional Chinese medicine composition for treating recurrent oral ulcer, a traditional Chinese medicine preparation and a preparation method. The traditional Chinese medicine composition for treating recurrent oral ulcer has the effects of supporting healthy qi, promoting tissue regeneration and clearing heat and detoxifying, is scientific and reasonable in prescription, and simple in preparation process. When used as a medicine for treating recurrent oral ulcer, the traditional Chinese medicine composition has the excellent characteristics of remarkable curative effect, short treatment course, low recurrence after recovery, small toxic and side effects, and can effectively avoid the adverse reactions caused by western medicines. The traditional Chinese medicine composition for treating recurrent oral ulcer is accurate and complete in syndrome differentiation, has the synergistic effect of components, treats symptoms and root causes at the same time, has good treatment effect and low recurrence rate, and is helpful to popularization and application in production practice.

The invention discloses a dental ulcer image recognition autoimmune disease blood index correlation analysis system, and relates to the technical field of medical informatics. Comprising a time sequence data acquisition module, a steady state baseline construction module, a cross-modal synchronous analysis module, a deviation degree calculation module, a disease risk judgment module and a risk early warning output module. The system constructs an individualized immune steady-state baseline by acquiring a dental ulcer image of a user and time sequence data of blood indexes related to autoimmunity; the image lesion dynamic evolution rate is used as a guide factor, time extrapolation is carried out on the blood indexes collected asynchronously, and synchronous predictive immune data are generated; by calculating the deviation degree of the prediction data and the steady state baseline, accurate and real-time judgment and early warning of the autoimmune disease risk are realized. According to the invention, the problem of evaluation delay caused by desynchrony of dental ulcer image and blood index acquisition time is effectively solved, and the timeliness and accuracy of health risk monitoring are improved.

The invention discloses traditional Chinese medicine nano hydrogel for treating recurrent oral ulceration as well as a preparation method and application of the traditional Chinese medicine nano hydrogel, and belongs to the technical field of medicines. According to the preparation method disclosed by the invention, the modified daochiSan is introduced into hydrogel prepared from sodium alginate and chitosan to prepare the modified daochiSan iron nano composite hydrogel (FeNPs at DaochiSan hydrogel), and the hydrogel has the characteristics of high mechanical strength, strong stability, high swelling ratio, long adhesion time, oxidation resistance, biocompatibility and the like; by improving the bioavailability, the stability, the targeting property and the controlled release property of the medicine, the compliance of a patient is improved, the treatment effect is improved, and a new way is provided for the inheritance and the application of the traditional modified Daochi powder.

Provided are a probiotic patch for preventing and treating oral ulcers, a method for producing the same, and use thereof. First, the present invention provides a use of Lactobacillus paracasei in the production of a medicament for preventing and treating oral ulcers, wherein the Lactobacillus paracasei contains Lactobacillus paracasei ET-22 cells and / or its extracellular metabolites, and the Lactobacillus paracasei ET-22 is a strain with the deposit number CGMCC No. 15077. Further, the present invention provides a probiotic composition containing Lactobacillus paracasei ET-22 cells and / or its extracellular metabolites, sodium carboxymethyl cellulose, propolis, borneol, a lubricant, glycerin, and Tween 20. The probiotic composition of the present invention can be made into a patch, can effectively prevent and treat oral ulcers, is safe and reliable, and has a remarkable effect.

The invention relates to the technical field of traditional Chinese medicine processing, and discloses a radish cream extraction method, which at least comprises: S1, respectively crushing radish and mirabilite, adding water, and uniformly mixing to obtain a mixture; s2, placing the mixture obtained in the step S1 in an environment with the temperature of 0-20 DEG C and the relative humidity of 1-60%; and S3, after the frost is separated out in the S2, collecting until the frost is separated out. According to the invention, the process for preparing the radish cream from the mirabilite is researched for the first time, and a basis is provided for production and clinical research significance of glucosinolate and sulforaphane in radishes and establishment of quality standards of the radish cream. The main component of the radish cream is recrystallized Na2SO4. 10H2O, and the result is obtained through experimental verification. The radishes and the mirabilite have a synergistic effect, so that the medicine is purer, and the effects of relieving swelling and pain and clearing away heat and toxic materials are enhanced. The radish cream is used for treating sore throat, mouth and tongue sores, swelling and aching of gum, acute and chronic pharyngolaryngitis, tonsillitis, stomatitis and oral ulcer symptoms.

The invention relates to the technical field of biological materials, and discloses a preparation method of novel antibacterial nano composite hydrogel for repairing diabetic oral ulcer. Comprising the following steps: grafting 2-formylphenylboronic acid on titanium carbide (MXene) nanosheets to form MXene (at) FPBA nanoparticles, carrying out an amidation reaction on lipoic acid and recombinant collagen to obtain modified recombinant collagen, doping the MXene (at) FPBA into the modified recombinant collagen system, and carrying out photo-crosslinking to obtain the novel antibacterial nano composite hydrogel. The hydrogel combines the strong anti-oxidation and anti-inflammatory capabilities of lipoic acid, does not need to add anti-inflammatory drugs, and also has good adhesiveness; the MXene (at) FPBA nano particles can be used for capturing bacteria and carrying out efficient sterilization; and the raw materials used by the material have biological safety. Therefore, the hydrogel has the antibacterial property and the anti-inflammatory function, and can comprehensively and efficiently manage and treat diabetic oral ulcer wounds.

The invention belongs to the technical field of preparation of grapefruit oil, and particularly relates to a composition containing grapefruit oil, a preparation method and application. The invention provides a pomelo oil-containing composition. The pomelo oil-containing composition comprises 10-12 parts of a pomelo oil extract and 1-2 parts of a polygonatum odoratum extracting solution. According to the invention, the grapefruit oil extract and the polygonatum odoratum extracting solution are specifically combined, so that the effective activity of the grapefruit oil extract is maintained, and the release of antioxidant and antibacterial functions of the grapefruit oil extract is promoted. Therefore, when the composition is applied to a corresponding product, the effects of inhibiting bacteria, resisting oxidation and repairing oral ulcer of the composition can be exerted, and the practicability is high.

The application discloses an oral ulcer image recognition autoimmune disease blood index correlation analysis system and relates to the technical field of medical informatics. The system comprises a time series data acquisition module, a steady-state baseline construction module, a cross-modal synchronous analysis module, a deviation calculation module, a disease risk determination module and a risk warning output module. The system acquires the time series data of the oral ulcer image and the autoimmune related blood index of the user, and constructs an individualized immune steady-state baseline. The dynamic evolution rate of the image lesion is used as a guide factor to time extrapolate the non-synchronous collected blood index, generate synchronous predictive immune data, calculate the deviation of the predictive data and the steady-state baseline, and realize accurate and real-time determination and early warning of the autoimmune disease risk. The application effectively solves the evaluation delay problem caused by the asynchronous collection of the oral ulcer image and the blood index, and improves the timeliness and accuracy of health risk monitoring.

The invention belongs to the technical field of daily chemicals, and particularly relates to Chinese herbal medicine three-color strip toothpaste and a preparation method thereof. The Chinese herbal medicine three-color strip toothpaste comprises a faint yellow paste body, a green paste body and a blue paste body, the faint yellow paste body comprises, by mass, 0.1%-2% of chitosan quaternary ammonium salt and 0.1%-1% of an ovateleaf holly bark extract, and the green paste body comprises, by mass, 0.002%-0.15% of sodium copper chlorophyllin and 0.1%-1% of the ovateleaf holly bark extract. The blue paste is prepared from the following components in percentage by mass: 0.03 to 0.15 percent of guaiazulene sodium sulfonate and 0.1 to 1 percent of ovateleaf holly bark extract. According to the Chinese herbal medicine three-color-strip toothpaste and the preparation method thereof provided by the invention, the three-color-strip toothpaste is obtained under the condition that exogenous pigments are not added; the toothpaste can achieve the compound effects of freshening breath, inhibiting dental plaque and oral pathogenic bacteria, resisting inflammation, diminishing swelling, resisting allergy, relieving gingivitis and promoting healing and repairing of recurrent oral ulceration, can promote enamel remineralization and pore repairing, and is high in effect synergy, paste stability and use safety.

The utility model discloses a dental pad capable of preventing teeth from being injured and bitten and capable of being inserted with a tube, which comprises a support frame which is a hard support frame, the protection pad wraps the supporting frame; wherein the protection pad comprises a tongue fence, an occlusal pad and a lip baffle, the occlusal pad is of an arc-shaped plate structure, the lip baffle is arranged on the outer side arc surface, the tongue fence is arranged on the inner side arc surface, and the tongue fence, the occlusal pad and the lip baffle form a tooth groove; the thickness of the occlusal pad is 2-5 mm, the protection pad is provided with a through hole, and the through hole penetrates through the lip shield, the occlusal pad and the tongue fence. The utility model has the characteristics that the tooth injury caused by tooth occlusion hard contact can be prevented, the oral traumatic ulcer caused by the fact that an unconscious epileptic mistakenly bites lips, cheeks and tongues can be avoided, the ventilation can be realized, the requirement of stomach tube insertion in clinical operation can be met, and the like.

The invention belongs to the field of microneedle transdermal drug delivery, and particularly relates to an acupoint drug delivery soluble evodia rutaecarpa microneedle as well as a preparation method and application thereof in treatment of oral ulcer. The preparation method comprises the following steps: modifying effective biological components in fructus evodiae to obtain a solid dispersion, and then mixing the solid dispersion with a needle tip matrix to prepare the drug-loaded microneedle. Wherein the effective biological component in the fructus evodiae is evodiamine (EVO) or rutaecarpin (RUT). The medicinal evodia soluble drug-loaded microneedle is prepared, and the medicinal evodia soluble drug-loaded microneedle is attached to the pelma Yongquan acupoint to treat oral ulcer through matching of the medicinal evodia and the acupoint.

The invention discloses hydrogel for ulcers and a preparation method thereof.The hydrogel is obtained through a cross-linking reaction with polyphenol substance modified gelatin, aldehyde natural polymers and methacrylate gelatin as frameworks, and the hydrogel has injectability and can be injected to oral ulcers or pressure ulcers, and the hydrogel can also be used as a hydrogel for ulcers or oral ulcers or pressure ulcers or oral ulcers or pressure ulcers or pressure ulcers or pressure ulcers or pressure ulcers or pressure ulcers or pressure ulcers or pressure ulcers or pressure ulcers or pressure ulcers or pressure ulcers. The hydrogel can be prepared into a sheet shape to be applied to the ulcer surface, has good biocompatibility, compression resistance, wet adhesion, angiogenesis promotion, hemostasis, inflammation resistance and oxidation resistance, and is beneficial to healing of oral ulcers and pressure ulcers.

The invention relates to the technical field of medicine, in particular to polypeptide and application thereof in preparation of medicine for treating oral mucosa diseases. The polypeptide disclosed by the invention can be used for treating recurrent aphthous oral ulceration and oral mucositis caused by anti-tumor treatment. The polypeptide disclosed by the invention has a remarkable treatment effect, can promote ulcer healing, and is dose-dependent and time-dependent; the polypeptide is high in safety, a degradation product is natural amino acid, and the polypeptide has a wide application prospect.

Provided is use of Lactobacillus paracasei in preparing a medicament for preventing and treating oral ulcer. The Lactobacillus paracasei comprises Lactobacillus paracasei ET-22 cells and / or Lactobacillus paracasei ET-22 extracellular metabolites. Lactobacillus paracasei ET-22 is a strain with deposition number CGMCC No. 15077. Also provided are a probiotic composition, a method for preparing same, and use thereof. The composition comprises Lactobacillus paracasei ET-22 cells and / or Lactobacillus paracasei ET-22 extracellular metabolites, and further comprises sodium carboxymethyl cellulose, propolis, borneol, a lubricant, glycerol, and Tween-20. Further provided is a probiotic patch for preventing and treating oral ulcer, a method for preparing same, and use thereof.

The invention belongs to the technical field of traditional Chinese medicines, and particularly relates to a traditional Chinese medicine composition for rapidly curing oral ulcer and a preparation method thereof. The traditional Chinese medicine composition for rapidly curing oral ulcer is prepared from the following raw materials: akebiaquinata, divaricate saposhnikovia root, rehmannia, radix bupleuri, coptis chinensis, cinnamon, poria cocos, angelica sinensis and liquorice. According to the theory of traditional Chinese medicine, properties, flavors and meridians tropism and effects of traditional Chinese medicines, treatment based on syndrome differentiation and reasonable compatibility are achieved, all the traditional Chinese medicines give full play to the synergistic effect, and the oral ulcer can be effectively and rapidly cured with the purposes of clearing away heat and toxic materials, dissipating blood stasis, diminishing swelling, promoting tissue regeneration and relieving pain.

The invention discloses an active polypeptide for promoting healing of oral ulcer and application thereof, and belongs to the technical field of biological medicines. The amino acid sequence of the active polypeptide NPTX3 capable of promoting healing of the oral ulcer is DLKPIAEDIPSLEK. An in-vitro experiment result shows that the polypeptide NPTX3 can remarkably promote the scratch closure of the human immortalized keratinocytes at the concentration as low as 500 pM. Transwell migration experiments further prove that the polypeptide NPTX3 can obviously enhance the migration ability of HaCaT cells at the concentrations of 1nM and 10nM, which prompts that the polypeptide NPTX3 may accelerate wound repair by promoting epithelial cell migration. In an SD (Sprague Dawley) rat oral ulcer model, the ulcer healing rate can be obviously improved by locally applying the polypeptide NPTX3 (1 nM, 10 nM). The polypeptide NPTX3 provided by the invention shows excellent activity of promoting cell migration and tissue repair at an extremely low dose, has the advantages of low effective dose, strong biological activity, high safety and the like, and provides an efficient and mild new choice for drug treatment of oral ulcer.

The invention relates to a composition for preventing or treating oral inflammation or oral ulcer, and belongs to the technical field of oral care medicines. The technical scheme of the invention is as follows: the composition contains one or more of lactose-N-trisaccharide and fucosyllactose, and / or lactose-N-tetrasaccharide (Lacto-N-tetraose, LNT) and / or lactose-N-neotetrasaccharide (Lacto-N-neotetraose, LNnT), and the preparation method of the composition comprises the following steps of: mixing the lactose-N-trisaccharide, the fucosyllactose and the lactose-N-tetraose and the lactose-N-neotetraose. According to the technical scheme, the problems that (1) sticking occurs in the tabletting process, and tablets with smooth surfaces cannot be prepared are solved, and (2) the stability problem of buccal tablets in the storage process is stabilized, and the stable and effective composition for treating or preventing inflammation is provided.

The invention discloses mouthwash for treating oral ulcer caused by chemoradiotherapy, which is mainly prepared from the following raw materials in percentage by weight: 0.15 percent to 0.25 percent of chlorhexidine gluconate, 0.015 percent to 0.025 percent of polypeptide of which the amino acid sequence is RWRWRW, 0.05 percent to 0.15 percent of sodium hyaluronate, 0.05 percent to 0.15 percent of menthol, 2.8 percent to 3.2 percent of humectant, 0.45 percent to 0.55 percent of sodium ascorbyl phosphate, 0.5 percent to 1 percent of sodium bicarbonate and the balance of distilled water. The mouthwash for treating the oral ulcer caused by the chemoradiotherapy not only has antibacterial and moisturizing functions, but also can relieve the pain degree of the oral ulcer caused by the chemoradiotherapy, reduce the infection risk and promote ulcer healing, the technical problem that an existing product is single in function is solved, a patient does not need to alternately use multiple preparations, and the compliance is high.

The application discloses a double-cover-plate dental orthodontic self-locking bracket, characterized in that the bracket further comprises a lock arranged on the bracket body and the cover plates and used for limiting the positions of the cover plates; the cover plates are cover plate one and cover plate two which are slidably arranged on the bracket body. The application sets the top of the double cover plates into a smooth arc shape, so that the bracket is smooth and round as a whole, the patients have a more suitable experience, and the side edges of the bracket can not stimulate the oral cavity and cause oral ulcer. The double cover plates are arranged, so that when the cover plates are opened, the two cover plates move to the two sides at the same time, the opening and closing stroke of the double cover plates is reduced by half compared with the single cover plate, the structure is compact, the protruding part is not too long when the cover plates are opened, the oral cavity is not uncomfortable, the moving stroke of the double cover plates is shortened, the disengagement length of the double cover plates from the guide rail is reduced, and the work is more stable.

The invention discloses an oral care composition with antibacterial and senile dementia prevention effects, which comprises the following raw materials: berberis poiretii schneid extract and folium eriobotryae extract, and the dosage ratio of the berberis poiretii schneid extract to the folium eriobotryae extract is (10: 1)-(1: 10). The berberis poiretii schneid extract and the folium eriobotryae extract in a proper proportion are selected to be compounded and combined, it is found that the obtained composition has the effect of preventing senile dementia and also has the effects of synergistic interaction, bacteriostasis and oral ulcer prevention and treatment, and the bacteriostatic effect is far better than that of single berberis poiretii schneid extract; on the basis, a series of oral care products with marketization potential are developed, and the oral care products are safe and free of side effects, so that middle-aged and elderly people can clean gingiva, prevent and treat oral ulcer and prevent or delay senile dementia in daily oral care behaviors such as tooth brushing and mouth rinsing, and the oral care products are safe and free of side effects. The product is an excellent daily necessity beneficial to the public for early prevention of senile dementia, and has a considerable application prospect.

The application discloses application of butyric acid in preparation of a medicine for treating oral ulcer, and belongs to the field of biological medicine. The butyric acid plays a therapeutic effect by increasing expression of tight junction proteins in oral mucosa tissue, reducing inflammatory reaction and promoting healing of oral ulcer. The application uses butyric acid to treat oral ulcer, evaluates the curative effect of butyric acid and explores the corresponding internal mechanism. The results show that the butyric acid has obvious effect in treating oral ulcer caused by chemotherapy, and provide a scientific basis for clinical application of butyric acid.