156 results about "Oral ulcers" patented technology

The invention discloses a double-crosslinking network hydrogel film for treating oral ulcer, a preparation method and application, and relates to the technical field of biomedical materials. According to the hydrogel film, a dual-network synergistic enhancement structure is constructed through covalent / non-covalent bi-crosslinking, the adhesion to oral mucosa is remarkably enhanced by adopting dopamine (DA) modified hyaluronic acid (HA), and the mechanical property is greatly improved by utilizing a bi-crosslinking network system of disulfide bond / double bond crosslinking (chitosan and CS) and hydrogen bond / catechol self-crosslinking (hyaluronic acid and HA); the antioxidant and anti-inflammatory characteristics of lipoic acid (LA) and the natural antibacterial property of chitosan (CS) are combined to play a synergistic effect, so that the antibacterial and anti-inflammatory effects are remarkably improved. Meanwhile, multifunctional modified materials such as metacrylic acid ester are introduced, so that the functionality and the application range of the hydrogel film are expanded. The preparation technology is optimized, it is ensured that the material is safe and effective, large-scale production is easy, and an efficient and reliable novel material is provided for oral ulcer treatment.

The invention provides a hydrogel microneedle patch for treating oral ulcer and a preparation method, and belongs to the technical field of biomedical engineering. The technical problems that in the traditional oral ulcer administration process, medicine is difficult to retain at the focus for a long time, is easily scoured by saliva and is influenced by tongue and cheek movement are solved. According to the technical scheme, the method comprises the following steps: 1) designing and preparing a microneedle patch mold; (2) synthesizing drug-loaded polydopamine nano particles; (3) preparing a microneedle patch; and 4) evaluating the performance of the microneedle patch. The invention has the following beneficial effects: on one hand, the combination of the drug-loaded nanoparticles and the hydrogel microneedle array can reduce the dosage through drug sustained release; and on the other hand, the problems of high drug instability, low targeting property, poor bioavailability and hindering treatment effect are effectively solved, and the preparation can be widely applied to the fields of drug sustained release, wound healing, tissue engineering and the like.

The invention provides a composition for preventing and treating oral ulcer and halitosis and a preparation method of the composition. The composition is prepared from the following raw materials in parts by weight: osmanthus fragrans leaching liquor, fresh rehmannia root leaching liquor, lactobacillus fermentation liquor, carbomer homopolymer A, polysorbate and auxiliary materials. The fresh rehmannia root is subjected to microbial fermentation, the content of effective substances is measured, and the composition for preventing and treating the oral ulcer and the halitosis prepared by the method is simple in component, safe and non-irritating to the oral cavity, has the application effects of efficiently resisting bacteria and removing the halitosis, can meet the requirements of people needing the composition, and has a good market prospect.

The present application belongs to the technical field of traditional Chinese medicine, and particularly relates to a traditional Chinese medicine composition for treating recurrent oral ulcer, a traditional Chinese medicine preparation and a preparation method. The traditional Chinese medicine composition for treating recurrent oral ulcer has the effects of supporting healthy qi, promoting tissue regeneration and clearing heat and detoxifying, is scientific and reasonable in prescription, and simple in preparation process. When used as a medicine for treating recurrent oral ulcer, the traditional Chinese medicine composition has the excellent characteristics of remarkable curative effect, short treatment course, low recurrence after recovery, small toxic and side effects, and can effectively avoid the adverse reactions caused by western medicines. The traditional Chinese medicine composition for treating recurrent oral ulcer is accurate and complete in syndrome differentiation, has the synergistic effect of components, treats symptoms and root causes at the same time, has good treatment effect and low recurrence rate, and is helpful to popularization and application in production practice.

The invention discloses a dental ulcer image recognition autoimmune disease blood index correlation analysis system, and relates to the technical field of medical informatics. Comprising a time sequence data acquisition module, a steady state baseline construction module, a cross-modal synchronous analysis module, a deviation degree calculation module, a disease risk judgment module and a risk early warning output module. The system constructs an individualized immune steady-state baseline by acquiring a dental ulcer image of a user and time sequence data of blood indexes related to autoimmunity; the image lesion dynamic evolution rate is used as a guide factor, time extrapolation is carried out on the blood indexes collected asynchronously, and synchronous predictive immune data are generated; by calculating the deviation degree of the prediction data and the steady state baseline, accurate and real-time judgment and early warning of the autoimmune disease risk are realized. According to the invention, the problem of evaluation delay caused by desynchrony of dental ulcer image and blood index acquisition time is effectively solved, and the timeliness and accuracy of health risk monitoring are improved.

Provided are a probiotic patch for preventing and treating oral ulcers, a method for producing the same, and use thereof. First, the present invention provides a use of Lactobacillus paracasei in the production of a medicament for preventing and treating oral ulcers, wherein the Lactobacillus paracasei contains Lactobacillus paracasei ET-22 cells and / or its extracellular metabolites, and the Lactobacillus paracasei ET-22 is a strain with the deposit number CGMCC No. 15077. Further, the present invention provides a probiotic composition containing Lactobacillus paracasei ET-22 cells and / or its extracellular metabolites, sodium carboxymethyl cellulose, propolis, borneol, a lubricant, glycerin, and Tween 20. The probiotic composition of the present invention can be made into a patch, can effectively prevent and treat oral ulcers, is safe and reliable, and has a remarkable effect.

The invention relates to the technical field of biological materials, and discloses a preparation method of novel antibacterial nano composite hydrogel for repairing diabetic oral ulcer. Comprising the following steps: grafting 2-formylphenylboronic acid on titanium carbide (MXene) nanosheets to form MXene (at) FPBA nanoparticles, carrying out an amidation reaction on lipoic acid and recombinant collagen to obtain modified recombinant collagen, doping the MXene (at) FPBA into the modified recombinant collagen system, and carrying out photo-crosslinking to obtain the novel antibacterial nano composite hydrogel. The hydrogel combines the strong anti-oxidation and anti-inflammatory capabilities of lipoic acid, does not need to add anti-inflammatory drugs, and also has good adhesiveness; the MXene (at) FPBA nano particles can be used for capturing bacteria and carrying out efficient sterilization; and the raw materials used by the material have biological safety. Therefore, the hydrogel has the antibacterial property and the anti-inflammatory function, and can comprehensively and efficiently manage and treat diabetic oral ulcer wounds.

The invention belongs to the technical field of preparation of grapefruit oil, and particularly relates to a composition containing grapefruit oil, a preparation method and application. The invention provides a pomelo oil-containing composition. The pomelo oil-containing composition comprises 10-12 parts of a pomelo oil extract and 1-2 parts of a polygonatum odoratum extracting solution. According to the invention, the grapefruit oil extract and the polygonatum odoratum extracting solution are specifically combined, so that the effective activity of the grapefruit oil extract is maintained, and the release of antioxidant and antibacterial functions of the grapefruit oil extract is promoted. Therefore, when the composition is applied to a corresponding product, the effects of inhibiting bacteria, resisting oxidation and repairing oral ulcer of the composition can be exerted, and the practicability is high.

The application discloses an oral ulcer image recognition autoimmune disease blood index correlation analysis system and relates to the technical field of medical informatics. The system comprises a time series data acquisition module, a steady-state baseline construction module, a cross-modal synchronous analysis module, a deviation calculation module, a disease risk determination module and a risk warning output module. The system acquires the time series data of the oral ulcer image and the autoimmune related blood index of the user, and constructs an individualized immune steady-state baseline. The dynamic evolution rate of the image lesion is used as a guide factor to time extrapolate the non-synchronous collected blood index, generate synchronous predictive immune data, calculate the deviation of the predictive data and the steady-state baseline, and realize accurate and real-time determination and early warning of the autoimmune disease risk. The application effectively solves the evaluation delay problem caused by the asynchronous collection of the oral ulcer image and the blood index, and improves the timeliness and accuracy of health risk monitoring.

The invention belongs to the technical field of daily chemicals, and particularly relates to Chinese herbal medicine three-color strip toothpaste and a preparation method thereof. The Chinese herbal medicine three-color strip toothpaste comprises a faint yellow paste body, a green paste body and a blue paste body, the faint yellow paste body comprises, by mass, 0.1%-2% of chitosan quaternary ammonium salt and 0.1%-1% of an ovateleaf holly bark extract, and the green paste body comprises, by mass, 0.002%-0.15% of sodium copper chlorophyllin and 0.1%-1% of the ovateleaf holly bark extract. The blue paste is prepared from the following components in percentage by mass: 0.03 to 0.15 percent of guaiazulene sodium sulfonate and 0.1 to 1 percent of ovateleaf holly bark extract. According to the Chinese herbal medicine three-color-strip toothpaste and the preparation method thereof provided by the invention, the three-color-strip toothpaste is obtained under the condition that exogenous pigments are not added; the toothpaste can achieve the compound effects of freshening breath, inhibiting dental plaque and oral pathogenic bacteria, resisting inflammation, diminishing swelling, resisting allergy, relieving gingivitis and promoting healing and repairing of recurrent oral ulceration, can promote enamel remineralization and pore repairing, and is high in effect synergy, paste stability and use safety.

The invention discloses hydrogel for ulcers and a preparation method thereof.The hydrogel is obtained through a cross-linking reaction with polyphenol substance modified gelatin, aldehyde natural polymers and methacrylate gelatin as frameworks, and the hydrogel has injectability and can be injected to oral ulcers or pressure ulcers, and the hydrogel can also be used as a hydrogel for ulcers or oral ulcers or pressure ulcers or oral ulcers or pressure ulcers or pressure ulcers or pressure ulcers or pressure ulcers or pressure ulcers or pressure ulcers or pressure ulcers or pressure ulcers or pressure ulcers or pressure ulcers. The hydrogel can be prepared into a sheet shape to be applied to the ulcer surface, has good biocompatibility, compression resistance, wet adhesion, angiogenesis promotion, hemostasis, inflammation resistance and oxidation resistance, and is beneficial to healing of oral ulcers and pressure ulcers.

The invention relates to the technical field of medicine, in particular to polypeptide and application thereof in preparation of medicine for treating oral mucosa diseases. The polypeptide disclosed by the invention can be used for treating recurrent aphthous oral ulceration and oral mucositis caused by anti-tumor treatment. The polypeptide disclosed by the invention has a remarkable treatment effect, can promote ulcer healing, and is dose-dependent and time-dependent; the polypeptide is high in safety, a degradation product is natural amino acid, and the polypeptide has a wide application prospect.

Provided is use of Lactobacillus paracasei in preparing a medicament for preventing and treating oral ulcer. The Lactobacillus paracasei comprises Lactobacillus paracasei ET-22 cells and / or Lactobacillus paracasei ET-22 extracellular metabolites. Lactobacillus paracasei ET-22 is a strain with deposition number CGMCC No. 15077. Also provided are a probiotic composition, a method for preparing same, and use thereof. The composition comprises Lactobacillus paracasei ET-22 cells and / or Lactobacillus paracasei ET-22 extracellular metabolites, and further comprises sodium carboxymethyl cellulose, propolis, borneol, a lubricant, glycerol, and Tween-20. Further provided is a probiotic patch for preventing and treating oral ulcer, a method for preparing same, and use thereof.

The invention discloses an active polypeptide for promoting healing of oral ulcer and application thereof, and belongs to the technical field of biological medicines. The amino acid sequence of the active polypeptide NPTX3 capable of promoting healing of the oral ulcer is DLKPIAEDIPSLEK. An in-vitro experiment result shows that the polypeptide NPTX3 can remarkably promote the scratch closure of the human immortalized keratinocytes at the concentration as low as 500 pM. Transwell migration experiments further prove that the polypeptide NPTX3 can obviously enhance the migration ability of HaCaT cells at the concentrations of 1nM and 10nM, which prompts that the polypeptide NPTX3 may accelerate wound repair by promoting epithelial cell migration. In an SD (Sprague Dawley) rat oral ulcer model, the ulcer healing rate can be obviously improved by locally applying the polypeptide NPTX3 (1 nM, 10 nM). The polypeptide NPTX3 provided by the invention shows excellent activity of promoting cell migration and tissue repair at an extremely low dose, has the advantages of low effective dose, strong biological activity, high safety and the like, and provides an efficient and mild new choice for drug treatment of oral ulcer.

The invention relates to a composition for preventing or treating oral inflammation or oral ulcer, and belongs to the technical field of oral care medicines. The technical scheme of the invention is as follows: the composition contains one or more of lactose-N-trisaccharide and fucosyllactose, and / or lactose-N-tetrasaccharide (Lacto-N-tetraose, LNT) and / or lactose-N-neotetrasaccharide (Lacto-N-neotetraose, LNnT), and the preparation method of the composition comprises the following steps of: mixing the lactose-N-trisaccharide, the fucosyllactose and the lactose-N-tetraose and the lactose-N-neotetraose. According to the technical scheme, the problems that (1) sticking occurs in the tabletting process, and tablets with smooth surfaces cannot be prepared are solved, and (2) the stability problem of buccal tablets in the storage process is stabilized, and the stable and effective composition for treating or preventing inflammation is provided.

The invention discloses mouthwash for treating oral ulcer caused by chemoradiotherapy, which is mainly prepared from the following raw materials in percentage by weight: 0.15 percent to 0.25 percent of chlorhexidine gluconate, 0.015 percent to 0.025 percent of polypeptide of which the amino acid sequence is RWRWRW, 0.05 percent to 0.15 percent of sodium hyaluronate, 0.05 percent to 0.15 percent of menthol, 2.8 percent to 3.2 percent of humectant, 0.45 percent to 0.55 percent of sodium ascorbyl phosphate, 0.5 percent to 1 percent of sodium bicarbonate and the balance of distilled water. The mouthwash for treating the oral ulcer caused by the chemoradiotherapy not only has antibacterial and moisturizing functions, but also can relieve the pain degree of the oral ulcer caused by the chemoradiotherapy, reduce the infection risk and promote ulcer healing, the technical problem that an existing product is single in function is solved, a patient does not need to alternately use multiple preparations, and the compliance is high.

The application discloses a double-cover-plate dental orthodontic self-locking bracket, characterized in that the bracket further comprises a lock arranged on the bracket body and the cover plates and used for limiting the positions of the cover plates; the cover plates are cover plate one and cover plate two which are slidably arranged on the bracket body. The application sets the top of the double cover plates into a smooth arc shape, so that the bracket is smooth and round as a whole, the patients have a more suitable experience, and the side edges of the bracket can not stimulate the oral cavity and cause oral ulcer. The double cover plates are arranged, so that when the cover plates are opened, the two cover plates move to the two sides at the same time, the opening and closing stroke of the double cover plates is reduced by half compared with the single cover plate, the structure is compact, the protruding part is not too long when the cover plates are opened, the oral cavity is not uncomfortable, the moving stroke of the double cover plates is shortened, the disengagement length of the double cover plates from the guide rail is reduced, and the work is more stable.

The invention discloses an oral care composition with antibacterial and senile dementia prevention effects, which comprises the following raw materials: berberis poiretii schneid extract and folium eriobotryae extract, and the dosage ratio of the berberis poiretii schneid extract to the folium eriobotryae extract is (10: 1)-(1: 10). The berberis poiretii schneid extract and the folium eriobotryae extract in a proper proportion are selected to be compounded and combined, it is found that the obtained composition has the effect of preventing senile dementia and also has the effects of synergistic interaction, bacteriostasis and oral ulcer prevention and treatment, and the bacteriostatic effect is far better than that of single berberis poiretii schneid extract; on the basis, a series of oral care products with marketization potential are developed, and the oral care products are safe and free of side effects, so that middle-aged and elderly people can clean gingiva, prevent and treat oral ulcer and prevent or delay senile dementia in daily oral care behaviors such as tooth brushing and mouth rinsing, and the oral care products are safe and free of side effects. The product is an excellent daily necessity beneficial to the public for early prevention of senile dementia, and has a considerable application prospect.

The application discloses application of butyric acid in preparation of a medicine for treating oral ulcer, and belongs to the field of biological medicine. The butyric acid plays a therapeutic effect by increasing expression of tight junction proteins in oral mucosa tissue, reducing inflammatory reaction and promoting healing of oral ulcer. The application uses butyric acid to treat oral ulcer, evaluates the curative effect of butyric acid and explores the corresponding internal mechanism. The results show that the butyric acid has obvious effect in treating oral ulcer caused by chemotherapy, and provide a scientific basis for clinical application of butyric acid.

The invention provides a soluble adhesive microneedle patch for treating severe oral ulceration and a preparation method and application thereof, and belongs to the technical field of biomedical materials.The soluble adhesive microneedle patch comprises an adhesive substrate and soluble microneedles distributed on one side of the adhesive substrate in an array mode; the adhesion substrate is prepared from an adhesion material and a natural polymer, has wet responsiveness, can generate softening and adhesion effects when meeting wet tissues, and is more fit with an irregular ulcer surface; the soluble microneedle is prepared from a drug-loaded biopolymeric material; after the soluble adhesive microneedle patch acts on the oral cavity of a patient, the microneedle firstly dissolves and releases the medicine to play the anti-inflammatory and ulcer surface healing promoting roles, and the adhesive substrate continuously adheres to the wound surface to play the wound surface protecting, antibacterial and antioxidant roles; the problem that an existing oral ulcer treatment medicine is easily limited by the flushing effect of saliva in the oral cavity and the epithelial barrier, and the curative effect is affected is solved.

This invention relates to a mouthwash for treating oral ulcers and its preparation method. The mouthwash comprises the following components in the indicated weight ratios: 100 parts deionized water, containing 5-35 parts sodium chloride, 1-10 parts sodium bicarbonate, 0.1-1 parts borneol, 0.1-1 parts peppermint oil, 1-5 parts vitamin E, and 1-5 parts vitamin B12. First, all the above materials (excluding deionized water) are mixed in the indicated weight ratio and ground into a fine powder finer than 400 mesh. Then, peppermint oil is sprayed onto the powder mixture and stirred evenly to obtain the prepared mouthwash powder. The powder is then packaged and sealed. To use, the mouthwash powder is poured into a bottle containing the corresponding weight of deionized water and shaken until fully dissolved before use. This mouthwash has significant effects in treating oral ulcers, providing timely pain relief, accelerating ulcer healing, and shortening the course of the disease.

This invention discloses a spray composition, its preparation method, an oral care device, and its application, belonging to the field of biomedical technology. The composition is a synergistic compound of a herbal enzyme solution prepared by a "cell wall breaking-enzymatic hydrolysis-fermentation" process and a lyophilized stem cell exosome powder. The herbal enzyme solution contains berberine ≥1.2 mg / mL and baicalin ≥1.0 mg / mL, exhibiting high anti-inflammatory (IL-1β inhibition rate ≥55%) and deodorizing (VSC decomposition rate ≥88%) effects. The lyophilized exosome powder is rich in VEGF (≥50 pg / mg protein) and TGF-β1 (≥30 pg / mg protein), promoting gingival repair. The stability and delivery challenges of exosomes are solved through "lyophilization and reconstitution + ultrasonic atomization," resulting in atomized particles of 1–10 μm (D50 = 1–5 μm). Experimental results show that the gingivitis redness and swelling subsides in ≥90% of cases, the gingival recession thickness increases by 0.4–0.6 mm in 8 weeks, fresh breath is maintained for 4–6 hours, and the healing cycle of oral ulcers is shortened by 40%–50%, achieving a synergistic effect of "immediate antibacterial and anti-inflammatory treatment + long-term tissue repair".

This invention relates to the field of biomedicine and hygiene disinfection products technology, and discloses a method for preparing a slightly acidic oxidizing potential hydrogel. The gel is made from slightly acidic oxidizing potential water and an inorganic gelling agent, lithium magnesium silicate. The preparation method includes: separately preparing strongly acidic oxidizing potential water and alkaline reducing potential water by electrolysis; mixing the two online in a preset ratio; adjusting the pH value to 5.0 to 6.5 through a neutralization reaction; subsequently adding lithium magnesium silicate; and then dispersing the mixture through high-speed shearing and sealing for static swelling to form a gel. This invention solves the problems of easy decomposition of available chlorine and gel liquefaction by utilizing an inorganic gel system, resulting in a gel with high stability and a long shelf life. This product solves the problem of easy loss of liquid disinfectants, prolongs the bactericidal effect time on wounds and oral ulcers, and is non-irritating and non-sensitizing to the skin, making it suitable for long-term disinfection of hands, skin, and mucous membranes.

The invention relates to the technical field of oral cavity and skin health care, and particularly discloses a cream for promoting oral mucosa skin healing, the cream comprises the following raw materials by weight: 5-10% of a functional component, 5-10% of a repairing component, 5-8% of an emulsifier, 3-5% of a stabilizer, 20-30% of a matrix, and the balance deionized water; the functional component comprises a kiwi fruit extracting solution; the repairing component comprises hyaluronic acid; the emulsifier is mixed stearate; the technical problems that an existing cream is single in function, and complex requirements of multiple stages and multiple targets in the oral mucosa and skin healing process are difficult to meet at the same time are solved; the obtained cream can be simultaneously suitable for healing of skin and oral mucosa, and is suitable for healing of skin wounds such as burns, scalds, scratches and the like; treating dermatitis, eczema and other skin inflammations; the traditional Chinese medicine composition can be used for treating oral mucosa such as oral ulcer, oral mucositis, thrush, erosive oral lichen planus and the like, and has a wide application prospect.

The invention discloses an oral ulcer intelligent microneedle patch based on guanosine vesicle slow release and a preparation method thereof, and relates to the technical field of drug research and development, and the key points of the technical scheme are that the intelligent microneedle patch can penetrate through an oral ulcer pseudo membrane to realize targeted delivery of drugs; long-acting slow release of a therapeutic drug (guanosine) is realized through the guanosine vesicles, and continuous anti-inflammatory and tissue repair effects are achieved; the guanosine is a natural nucleoside and is an important construction unit of the supramolecular hydrogel. Therefore, more diversified supramolecular hydrogels based on guanosine and derivatives thereof also appear in continuous modification. The guanosine borate supramolecular hydrogel is used as a nano-scaffold with good biocompatibility and stimulation responsiveness, and has the potential of conveying various therapeutic drugs in the aspect of drug conveying. The intelligent microneedle patch can monitor a plurality of key physiological parameters of an ulcer microenvironment in real time, and diagnosis and treatment integration is achieved.

The invention discloses a traditional Chinese medicine composition for treating radiation-induced oral ulceration and application thereof. The traditional Chinese medicine composition comprises the following traditional Chinese medicine raw materials in parts by weight: 6-10 parts of radix sophorae flavescentis, 6-10 parts of liquorice, 6-10 parts of diaphragma juglandis and 6-9 parts of rhizoma corydalis. The inventor of the application screens the traditional Chinese medicine raw materials capable of clearing heat and drying dampness, promoting blood circulation to arrest pain, astringing and promoting tissue regeneration, strengthening body resistance and detoxifying according to many years of medicine practicing experience and in combination with the theory of traditional Chinese medicine, under the combined action of the raw materials, oral ulceration, red and swollen and pain symptoms caused by radiation can be remarkably improved, and the traditional Chinese medicine composition has a remarkable curative effect on radiation-induced oral ulceration.

This application provides a protective dental crown, comprising: a dental crown; and a retaining ring detachably connected to the side of the dental crown. The dental crown is fitted onto a target tooth for protecting missing teeth in elderly comatose patients. The retaining ring is fitted onto teeth surrounding the target tooth to secure the dental crown. Applied to comatose elderly patients, the crown covers the missing tooth, and then a retaining ring of appropriate size is fitted onto the patient's healthy teeth to secure the crown. This isolates the defective tooth, preventing contact with oral tissues and complications such as oral ulcers. The solution is simple to operate, convenient to use, and inexpensive, facilitating its widespread adoption.

The invention relates to the technical field of medicines, in particular to application of a PDE4D inhibitor to preparation of a medicine for treating or preventing oral ulcer. The PDE4D inhibitor spray provided by the invention is used as a treatment scheme, can promote healing of oral ulcer, is simple and safe to operate, and is combined with an existing local treatment medicine to avoid single effect and improve the compliance of a patient.

This invention provides a fermented Scutellaria baicalensis health beverage, its preparation method, and its application, belonging to the field of health food processing technology. This invention combines Scutellaria baicalensis, Panax notoginseng, and licorice, and then processes them with brown rice and Coix seed through gelatinization and fermentation steps to obtain a fermented Scutellaria baicalensis health beverage that overcomes the bitterness and adverse effects on consumption of Scutellaria baicalensis in existing technologies. The product provided by this invention has a smooth texture, a slightly sour taste with a sweet aftertaste, a uniform texture without sedimentation or layering, a pleasant herbal aroma, a uniform and translucent light off-white color, and excellent quality. It has a significant therapeutic effect on oral ulcers, with efficacy reaching the level of existing conventional Scutellaria baicalensis medications. This product has a low sugar content and contains no other additives, making it suitable for children, diabetic patients, and other groups, and has extremely high commercial promotion value.

The application discloses application of dendrobium nobile in preparation of a medicine for treating oral ulcer in combination with ginger, and relates to the technical field of biological medicine.The dendrobium nobile exosome in combination with the ginger exosome can treat oral ulcer, can simultaneously efficiently resist inflammation, resist oxidation, and promote epithelial cell proliferation and migration, so that the healing process of oral ulcer can be fundamentally accelerated.