21 results about "Ulcer healing" patented technology

Abstract Present invention discloses an oral ulcer patch which adheres to a surface of a mouth ulcer and reduces pain associated with the mouth ulcer while at the same time accelerating healing of the mouth mucosa. The oral ulcer patch comprises an anti-inflammatory agent, an analgesic agent; a healing agent; an agent that forms a protective barrier upon reacting5 with saliva in the mouth, wherein the patch adheres to the moist ulcer area inside the mouth, forms a protective barrier, releases active analgesic and anti-inflammatory agents, and wherein the application of the patch to the ulcer reduces the pain caused by the ulcer and reduces the healing time of the ulcer. 10 Abstract Present invention discloses an oral ulcer patch which adheres to a surface of a mouth ulcer and reduces pain associated with the mouth ulcer while at the same time accelerating healing of the mouth mucosa. The oral ulcer patch comprises an anti-inflammatory agent, 5 an analgesic agent; a healing agent; an agent that forms a protective barrier upon reacting with saliva in the mouth, wherein the patch adheres to the moist ulcer area inside the mouth, forms a protective barrier, releases active analgesic and anti-inflammatory agents, and wherein the application of the patch to the ulcer reduces the pain caused by the ulcer and reduces the healing time of the ulcer. 10 20 24 28 71 87 23 D ec 2 02 4 2 0 2 4 2 8 7 1 8 7 2 3 D e c 2 0 2 4 A b s t r a c t 5 1 0

The invention discloses an active polypeptide for promoting healing of oral ulcer and application thereof, and belongs to the technical field of biological medicines. The amino acid sequence of the active polypeptide NPTX3 capable of promoting healing of the oral ulcer is DLKPIAEDIPSLEK. An in-vitro experiment result shows that the polypeptide NPTX3 can remarkably promote the scratch closure of the human immortalized keratinocytes at the concentration as low as 500 pM. Transwell migration experiments further prove that the polypeptide NPTX3 can obviously enhance the migration ability of HaCaT cells at the concentrations of 1nM and 10nM, which prompts that the polypeptide NPTX3 may accelerate wound repair by promoting epithelial cell migration. In an SD (Sprague Dawley) rat oral ulcer model, the ulcer healing rate can be obviously improved by locally applying the polypeptide NPTX3 (1 nM, 10 nM). The polypeptide NPTX3 provided by the invention shows excellent activity of promoting cell migration and tissue repair at an extremely low dose, has the advantages of low effective dose, strong biological activity, high safety and the like, and provides an efficient and mild new choice for drug treatment of oral ulcer.

The invention discloses mouthwash for treating oral ulcer caused by chemoradiotherapy, which is mainly prepared from the following raw materials in percentage by weight: 0.15 percent to 0.25 percent of chlorhexidine gluconate, 0.015 percent to 0.025 percent of polypeptide of which the amino acid sequence is RWRWRW, 0.05 percent to 0.15 percent of sodium hyaluronate, 0.05 percent to 0.15 percent of menthol, 2.8 percent to 3.2 percent of humectant, 0.45 percent to 0.55 percent of sodium ascorbyl phosphate, 0.5 percent to 1 percent of sodium bicarbonate and the balance of distilled water. The mouthwash for treating the oral ulcer caused by the chemoradiotherapy not only has antibacterial and moisturizing functions, but also can relieve the pain degree of the oral ulcer caused by the chemoradiotherapy, reduce the infection risk and promote ulcer healing, the technical problem that an existing product is single in function is solved, a patient does not need to alternately use multiple preparations, and the compliance is high.

This invention relates to a mouthwash for treating oral ulcers and its preparation method. The mouthwash comprises the following components in the indicated weight ratios: 100 parts deionized water, containing 5-35 parts sodium chloride, 1-10 parts sodium bicarbonate, 0.1-1 parts borneol, 0.1-1 parts peppermint oil, 1-5 parts vitamin E, and 1-5 parts vitamin B12. First, all the above materials (excluding deionized water) are mixed in the indicated weight ratio and ground into a fine powder finer than 400 mesh. Then, peppermint oil is sprayed onto the powder mixture and stirred evenly to obtain the prepared mouthwash powder. The powder is then packaged and sealed. To use, the mouthwash powder is poured into a bottle containing the corresponding weight of deionized water and shaken until fully dissolved before use. This mouthwash has significant effects in treating oral ulcers, providing timely pain relief, accelerating ulcer healing, and shortening the course of the disease.

This invention belongs to the field of traditional Chinese medicine technology, specifically relating to a herbal antibacterial hydrogel for ulcer healing, its preparation method, and its application. The hydrogel is composed of a herbal composition and a matrix. The herbal composition includes dandelion, angelica, scrophularia, forsythia, phellodendron, atractylodes, angelica dahurica, and raw licorice. The matrix contains chitosan, polyvinyl alcohol, water, and glacial acetic acid. The effective components of the herbal medicine are extracted by decoction, concentrated, and freeze-dried to obtain a freeze-dried powder. This powder is then mixed with a chitosan aqueous solution and cross-linked using a liquid nitrogen cyclic freezing method to form the hydrogel. This invention closely addresses the core pathogenesis of diabetic foot ulcers—"blood stasis, dampness, and heat (toxin)"—allowing the various herbs to synergistically exert their effects of clearing heat and detoxifying, promoting blood circulation and removing blood stasis, drying dampness and astringing sores, and nourishing blood and promoting tissue regeneration. The chitosan matrix endows the hydrogel with good biocompatibility, antibacterial properties, and sustained-release drug properties, which can improve the microenvironment of the ulcer wound, inhibit inflammatory responses, and promote granulation tissue growth, effectively promoting the healing of skin sores such as diabetic foot ulcers, and has broad application prospects.

The invention provides a traditional Chinese medicine composition, a traditional Chinese medicine preparation, a preparation method and application, and particularly belongs to the technical field of traditional Chinese medicine preparation. The traditional Chinese medicine composition comprises the following components in parts by weight: 7-11 parts of champignon, 19-29 parts of aloe, 10-14 parts of fructus chebulae immaturus, 5-7 parts of rhizoma zingiberis, 5-7 parts of rhizoma nardostachyos, 4-6 parts of fructus chebulae and 2-4 parts of halite. The traditional Chinese medicine composition can improve the activity of SOD, inhibit the content of MDA, reduce damage of oxygen free radicals to gastric mucosa, effectively relieve inflammatory response, achieve anti-inflammation, improve ulcer surface blood flow, improve gastric mucosa damage, reduce ulcer surfaces and promote ulcer healing, and therefore the protective effect on gastric ulcer is achieved. The results of network pharmacology, molecular docking speculation and Western blot method verification show that the FMST plays an anti-inflammatory role through a TLR4 / MyD88 / NF-kappa B signal channel.

The invention relates to a traditional Chinese medicine composition for treating ulcerative colitis in a remission stage as well as a preparation method and application of the traditional Chinese medicine composition. The traditional Chinese medicine composition comprises the following traditional Chinese medicine raw materials in parts by weight: 5-35 parts of humifuse euphorbia herb, 3-12 parts of carbonized sanguisorba root, 3-12 parts of gordon euryale seed, 1-6 parts of rhizoma bletillae, 0.5-5 parts of gallnut, 0.06-0.3 part of catechu and 0.02-0.12 part of pearl powder. According to the traditional Chinese medicine, the effects of all the medicines are synergistic, and all the medicines are combined to achieve the effects of attacking evil, tonifying deficiency, clearing waste heat, dispersing blood stasis, stopping bleeding, tonifying spleen and consolidating root; dynamic and static are combined, blood circulation is promoted, stasis is prevented, astringency is induced, and positive consumption is prevented. The multiple medicines synergistically play roles in healing sore, promoting tissue regeneration and repairing intestinal mucosa, directly refer to the core goal of healing ulcerative colitis, and are suitable for the pathogenesis characteristics of gradual decline of damp-heat and spleen deficiency reveal in the remission period of ulcerative colitis.

1. Name of the product in this design: Red Light Rotating Magnetic Therapy Device. 2. Purpose of this design: A therapeutic instrument for the pelvic floor to reduce inflammation, pain, swelling, and promote wound and ulcer healing. 3. The key design feature of this product is its shape. 4. The image or photograph that best illustrates the design's key points: a 3D model.

The invention belongs to the technical field of medicines, and particularly relates to application of a pharmaceutical composition in preparation of a medicine for treating oral ulcer. According to the application of the medicine composition in preparation of the medicine for treating the oral ulcer, through the synergistic effect of aspirin, acetaminophen and caffeine, the effects of resisting inflammation, easing pain and promoting ulcer healing can be achieved at the same time, the problem that in the prior art, inflammation control and pain relief are difficult to be effectively achieved at the same time is solved, and the medicine composition is worthy of popularization and application. The traditional Chinese medicine composition has the advantages that the oral mucosa inflammatory factors IL-2, IL-6 and TNF-alpha expression conditions can be obviously reduced, epithelial regeneration related pathway genes and expression are promoted to be increased, activated Mmp2 is inhibited, Bcl2 gene expression is increased, cell apoptosis signals are reduced, oral mucosa ulcer is relieved, the inflammatory state of oral ulcer is improved from the molecular level, and ulcer healing is accelerated.

This invention provides a self-generating ulcer dressing, belonging to the field of medical device technology. The self-generating ulcer dressing comprises a self-generating layer and a conventional ulcer dressing. The conventional ulcer dressing includes a medicated layer and a protective layer, with the self-generating layer either independently between or integrated with both. The self-generating layer is composed of membrane materials such as polylactic acid, polarized cellulose dressing, and polyvinyl alcohol, either alone or in combination with other strongly electronegative biocompatible materials. It generates a Maxwell pulse electric field under external force, accelerating cell regeneration and tissue repair, and promoting ulcer healing. The self-generating layer can be combined with the medicated layer or the protective layer. The protective layer material can be selected from polyacrylic acid resin, diethyl phthalate, or hydroxypropyl methylcellulose, etc. The self-generating ulcer dressing can have a multi-layered or staggered structure, with layers connected by coating, mixing, or compression. The self-generating ulcer patch of the present invention has a flexible design and does not require an external power source. When the self-generating ulcer patch is continuously rubbed and pressed, the self-generating layer is subjected to continuous force to generate a Maxwell pulse electric field and a pulse field current, which can activate cells, promote blood circulation, and work synergistically with ulcer medication to accelerate cell regeneration and tissue repair, thereby achieving the effect of promoting ulcer wound healing.

The present invention provides a device and combination for promoting the healing of ulcers on the body surface. [Solution] A body surface ulcer healing promotion device comprising a glucose concentration sensor 11 for detecting the glucose concentration in the exudate of an ulcer 2 on the body surface 1, vibrators 21A, 21B, and 21C for applying vibration to the ulcer 2, and a control device 31 for controlling the vibration of vibrators 21A, 21B, and 21C based on the glucose concentration in the exudate; and a combination for promoting ulcer healing comprising a vibrator for applying vibration stimulation to an ulcer on the body surface and its vicinity, and a dressing material positioned between the ulcer and the vibrator, wherein the vibration stimulation is performed by vibration of the vibrator via the dressing material.

The invention discloses a traditional Chinese medicine composition for preventing and / or treating oral ulcer, a traditional Chinese medicine preparation and a preparation method and application thereof, and belongs to the field of traditional Chinese medicine. The traditional Chinese medicine composition is prepared from honeysuckle leaves, scutellaria baicalensis, rhizoma et radix baphicacanthis cusiae, lophatherum gracile, radix rehmanniae recen, gallnut and borneol according to a specific ratio through a water extraction, alcohol extraction or water extraction and alcohol precipitation process. The traditional Chinese medicine preparation comprises an effective amount of traditional Chinese medicine composition and pharmaceutically acceptable auxiliary materials. The traditional Chinese medicine composition provided by the invention is suitable for oral ulcer caused by heart and spleen heat accumulation and fire excess from yin deficiency on the basis of the treatment principle of combining heat clearing, detoxifying, yin nourishing and fire lowering, and can effectively relieve pain and swelling symptoms and promote ulcer healing. Experiments show that the traditional Chinese medicine preparation has the effects of resisting inflammation, resisting oxidation and promoting mucous membrane repair, is mild in medicine property and high in safety, and can effectively solve the problem that an existing traditional Chinese medicine preparation for treating dental ulcer is difficult to treat both symptoms and root causes.

The invention discloses a traditional Chinese medicine formula for preventing and treating diabetic foot. The traditional Chinese medicine formula is prepared from deer root, perillaseed, coix seed, motherwort, herba siegesbeckiae, turmeric, mango leaf, sappan wood, kudzuvine root, nettle, Chinese pulsatilla root, rhizoma dioscoreae nipponicae, centipede and leech. The traditional Chinese medicine composition has the advantages that the medicines are combined, the pathological links of promoting blood circulation to remove meridian obstruction, resisting inflammation and detoxifying, promoting repair, conditioning the whole body and acting on the diabetic foot at multiple targets are realized, the symptoms such as foot pain, swelling and numbness are relieved, the ulcer healing is promoted, the treatment effect is good, the side effect is small, the treatment period is short, and the life quality of patients can be effectively improved.

The invention discloses emulsifiable paste for treating eczema and dermatitis (seborrheic dermatitis) and a preparation method thereof, and belongs to the technical field of eczema and dermatitis (seborrheic dermatitis) medicines, the emulsifiable paste is prepared from the following raw materials in parts by weight: 6-10 parts of rhinacanthus nasutus, 6-10 parts of jatropha curcas, 6-10 parts of catechu, 6-10 parts of breynia fruticosa, 15-20 parts of coal tar, 40-80 parts of water, 40-50 parts of an emulsifier and 0.05-0.1 part of a preservative. The preparation method comprises the following steps: decocting the rhinacanthus nasutus, the jatropha curcas, the catechu and the breynia fruticosa with water, and then fishing out the medicinal materials to obtain medicine slurry; and mixing the medicine slurry, coal tar, an emulsifier and a preservative, adding into an emulsifying machine, and emulsifying to obtain the product. The external emulsifiable paste for eczema and dermatitis (seborrheic dermatitis) has the effects of astringing ulcers, astringing wounds and stopping bleeding, resisting viruses, dissipating blood stasis and diminishing swelling, relieving pain and itching, controlling pathogenic organisms on skin, promoting skin repair, inhibiting reproduction of viruses and fungi and the like.

Use of red nocardia cell wall skeleton in the treatment of recurrent aphthous ulcer. The recurrent aphthous ulcer is selected from any one or combination of the following: mild recurrent aphthous ulcer, herpetic recurrent aphthous ulcer, severe recurrent aphthous ulcer. After administration, the ulcer can be observed to disappear, the hyperemia can be observed to disappear, and the pain symptoms can be observed to disappear.

This application discloses a traditional Chinese medicine oral ulcer patch containing camellia oil and its preparation method, belonging to the field of traditional Chinese medicine technology. The traditional Chinese medicine oral ulcer patch containing camellia oil, by weight fraction, comprises: 7.1-9.1 parts camellia oil, 5-7 parts propolis, 2-4 parts Bletilla striata extract, 2-4 parts honeysuckle extract, 2-4 parts Artemisia argyi volatile oil, 4.4-6.4 parts collagen peptides, 14-16 parts polyvinyl alcohol, 4-6 parts hydroxypropyl methylcellulose, 4-6 parts glycerin, 1-3 parts polyethylene glycol, 0.2-0.4 parts benzoate, 0.1-0.3 parts menthol, and 0.5-1.5 parts vitamin E. This traditional Chinese medicine oral ulcer patch not only has anti-inflammatory effects, relieves oral ulcer pain, and promotes ulcer healing, but also forms a stable protective film layer in the oral cavity, effectively isolating external stimuli such as food friction and saliva erosion, providing a stable microenvironment for mucosal repair.

The invention belongs to the field of traditional Chinese medicine preparations, and discloses radix astragali and rhizoma atractylodis macrocephalae healing-promoting oral granules for regulating a chronic wound microenvironment, a preparation process of the granules and application of the granules in chronic wound treatment. The radix astragali and rhizoma atractylodis macrocephalae healing promoting oral granules are prepared from 25-35 parts of raw radix astragali, 10-20 parts of radix pseudostellariae, 10-20 parts of fried rhizoma atractylodis macrocephalae, 25-35 parts of radix salviae miltiorrhizae, 10-20 parts of fructus lycii and 10-20 parts of fructus corni through gradient ethanol extraction and astragaloside enrichment processes. According to the granules, systematic regulation of wound surface microenvironment steady state is realized in an oral dosage form for the first time, and triple pathological links of high glucose-infection-ischemia of chronic wound surfaces are synchronously improved through a synergistic effect of a dogwood fruit pulp blood glucose reducing component and a high-proportion astragalus membranaceus / salvia miltiorrhiza healing promoting component; clinical tests show that when the oral granules are singly used for treating the deep chronic refractory ulcer, the healing time is shortened by 32% compared with that of red ointment, and the healing rate is increased to 76.3%.

The invention discloses a traditional Chinese medicine compound decoction for treating oral mucosa diseases, belongs to the technical field of traditional Chinese medicines, and particularly relates to a traditional Chinese medicine compound decoction for treating oral mucosa diseases, which is suitable for oral ulcer, oral lichen planus, herpes stomatitis and other mucosa lesions. The core innovation points are as follows: radix bupleuri and radix scutellariae synergistically sooth the liver and clear heat, prepared rehmannia root and angelica sinensis promote mucous membrane repair, white peony root and ligusticum wallichii regulate immune balance, and ginger and jujube enhance anti-oxidation defense. Decoction parameters are strictly limited in the preparation process, loss of effective components is avoided, addition of chemical auxiliary materials is forbidden, and the completeness of the medicine effect is ensured. According to the prescription, through a multi-target-point synergistic effect, mucosa inflammation is rapidly relieved, ulcer healing is accelerated, and the recurrence frequency is remarkably reduced. Clinical verifications prove that the total effective rate of cases with the disease course of more than or equal to 3 months and the recurrence of more than or equal to 2 times per month is more than or equal to 90%, the safety is high, and mucous membrane stimulation or systematic side effects are avoided.

The invention provides traditional Chinese medicine powder for treating oral ulcer and a preparation method thereof, and belongs to the technical field of traditional Chinese medicine preparations. The traditional Chinese medicine powder is prepared from the following raw medicinal materials in parts by weight: 8-15 parts of pseudo-ginseng, 10-20 parts of indigo naturalis, 15-25 parts of calcined cuttlebone, 5-12 parts of catechu, 1-3 parts of menthol, 1-4 parts of borneol, 10-18 parts of astragalus membranaceus, 6-12 parts of liquorice and pharmaceutically acceptable powder auxiliary materials, has the effects of clearing away heat and toxic materials, relieving swelling and pain, removing slough and promoting tissue regeneration, and tonifying qi and healing sore, can quickly relieve pain, and is free of toxic and side effects. The ulcer healing time is obviously shortened, the local immunity can be regulated, and the recurrence frequency is reduced.

The invention discloses a traditional Chinese medicine composition for treating recurrent oral ulceration, and belongs to the technical field of traditional Chinese medicines. The traditional Chinese medicine composition is prepared from the following raw materials in parts by mass: 10g of radix aconiti lateralis preparata, 10g of herba asari, 18g of endothelium corneum gigeriae galli, 30g of herba lysimachiae, 20g of radix astragali, 10g of raw liquorice root, 15g of honeysuckle flower and 30g of herba hedyotis. The traditional Chinese medicine composition can effectively and rapidly relieve pain, accelerate ulcer healing, reduce ulcer recurrence frequency and achieve the effect of treating both symptoms and root causes.

The invention relates to the technical field of medical apparatus and instruments, in particular to an oral ulcer targeted sustained-release patch based on a nanofiber membrane and a preparation method thereof.The oral ulcer targeted sustained-release patch comprises PLGA, chitosan, silk fibroin and other components and further comprises targeted peptide, adhesion enhancing peptide, a dual-response cross-linking agent, graphene oxide quantum dots and antibacterial healing promoting ingredients; the nanofiber membrane is of a core-shell gradient structure, corresponding active ingredients are loaded on a core and a shell respectively, a synergistic slow-release network is constructed through a dual-response cross-linking agent, a synergistic system is formed by antibacterial components, and the integrated function of targeted adhesion, graded drug release and healing promotion is achieved. The patch is excellent in targeting and adhesion, and can avoid falling off and prolong the action time. Graded drug release meets the ulcer healing requirement, and the safety is high; antibacterial and healing-promoting components have a synergistic effect, so that the healing effect is good; the material is good in biocompatibility and free of stimulation, and the oral ulcer treatment effect is remarkably improved.