48 results about "Ulcer healing" patented technology

The invention discloses a traditional Chinese medicine ointment as well as a preparation method and application thereof. The preparation method of the traditional Chinese medicine ointment provided by the invention comprises the following steps: adding a gamboge medicinal material into water, carrying out reflux cooking, filtering filtrate, concentrating into paste, drying and crushing to obtain gamboge powder; sulfur powder and realgar powder are added into tung oil for paste refining; cooling the obtained paste, adding gamboge powder and pearl powder, blending, and sterilizing; cooling the obtained ointment body, adding musk, and mixing to obtain the traditional Chinese medicine ointment. The traditional Chinese medicine ointment provided by the invention has the advantages of small proportion of three yellow, small toxicity and strong drug effect, can significantly reduce the ulcer area and promote ulcer healing in a short time, and has a significant effect.

The invention discloses a long-time strong-adhesion tissue repair patch and a preparation method thereof, and the preparation method comprises the following steps: adding an adhesion component, an anti-swelling component and alpha-ketoglutaric acid into a colloidal aqueous solution of a patch matrix material to obtain a precursor solution; and pouring the precursor solution into a patch mold, carrying out ultraviolet curing, and drying the obtained gel to obtain the patch. From the selection of materials and chemical bonds, physical and chemical bonds such as amido bonds, disulfide bonds and catechol groups are combined, so that the adhesion strength is improved, the adhesion duration is prolonged, and the adhesive has excellent anti-swelling performance and mechanical performance, can effectively isolate external saliva, food residues and the like when being applied to the oral cavity, reduces infection of ulcer wounds, and has a good application prospect. The dental ulcer healing is accelerated, and the method also has a relatively good application prospect in the field of tissue repair.

The invention relates to the technical field of toothpaste, and discloses toothpaste with biological activity and deodorization and a preparation method thereof, the toothpaste comprises the following raw materials: sucralose, glycerin, sorbitol, benzyl alcohol, sodium dihydrogen phosphate, water, hydrated silica, sodium carboxymethyl cellulose, xanthan gum, a deodorization modification material, a vitamin E inclusion compound, a foaming agent and essence; wherein the deodorizing modified material is obtained by modifying an antibacterial agent triclosan on the surface of tourmaline powder, so that the toothpaste is endowed with excellent antibacterial and deodorizing performance; the vitamin E clathrate compound is a protamine derivative coating vitamin E. In the use process, positive charges carried by protamine and mucous membranes with negative charges are utilized to generate an electrostatic adsorption effect, and the vitamin E clathrate compound is adhered to ulcers, so that the effects of positioning, slow-release and targeting are achieved, ulcer healing is promoted, and the healthy environment in the oral cavity is protected.

The invention provides a tigorasone fumarate injection and a preparation method thereof, and belongs to the technical field of medicines. The injection provided by the invention is prepared from tigorasone fumarate, a pH (Potential of Hydrogen) regulator and water for injection. The tegorasone fumarate injection has various medicine applications of inhibiting gastric acid secretion, promoting gastric ulcer healing and preventing reflux esophagitis. The injection can tolerate terminal sterilization, and is high in safety and good in stability.

Abstract Present invention discloses an oral ulcer patch which adheres to a surface of a mouth ulcer and reduces pain associated with the mouth ulcer while at the same time accelerating healing of the mouth mucosa. The oral ulcer patch comprises an anti-inflammatory agent, an analgesic agent; a healing agent; an agent that forms a protective barrier upon reacting5 with saliva in the mouth, wherein the patch adheres to the moist ulcer area inside the mouth, forms a protective barrier, releases active analgesic and anti-inflammatory agents, and wherein the application of the patch to the ulcer reduces the pain caused by the ulcer and reduces the healing time of the ulcer. 10 Abstract Present invention discloses an oral ulcer patch which adheres to a surface of a mouth ulcer and reduces pain associated with the mouth ulcer while at the same time accelerating healing of the mouth mucosa. The oral ulcer patch comprises an anti-inflammatory agent, 5 an analgesic agent; a healing agent; an agent that forms a protective barrier upon reacting with saliva in the mouth, wherein the patch adheres to the moist ulcer area inside the mouth, forms a protective barrier, releases active analgesic and anti-inflammatory agents, and wherein the application of the patch to the ulcer reduces the pain caused by the ulcer and reduces the healing time of the ulcer. 10 20 24 28 71 87 23 D ec 2 02 4 2 0 2 4 2 8 7 1 8 7 2 3 D e c 2 0 2 4 A b s t r a c t 5 1 0

The invention relates to the technical field of medicine, in particular to polypeptide and application thereof in preparation of medicine for treating oral mucosa diseases. The polypeptide disclosed by the invention can be used for treating recurrent aphthous oral ulceration and oral mucositis caused by anti-tumor treatment. The polypeptide disclosed by the invention has a remarkable treatment effect, can promote ulcer healing, and is dose-dependent and time-dependent; the polypeptide is high in safety, a degradation product is natural amino acid, and the polypeptide has a wide application prospect.

The invention discloses an active polypeptide for promoting healing of oral ulcer and application thereof, and belongs to the technical field of biological medicines. The amino acid sequence of the active polypeptide NPTX3 capable of promoting healing of the oral ulcer is DLKPIAEDIPSLEK. An in-vitro experiment result shows that the polypeptide NPTX3 can remarkably promote the scratch closure of the human immortalized keratinocytes at the concentration as low as 500 pM. Transwell migration experiments further prove that the polypeptide NPTX3 can obviously enhance the migration ability of HaCaT cells at the concentrations of 1nM and 10nM, which prompts that the polypeptide NPTX3 may accelerate wound repair by promoting epithelial cell migration. In an SD (Sprague Dawley) rat oral ulcer model, the ulcer healing rate can be obviously improved by locally applying the polypeptide NPTX3 (1 nM, 10 nM). The polypeptide NPTX3 provided by the invention shows excellent activity of promoting cell migration and tissue repair at an extremely low dose, has the advantages of low effective dose, strong biological activity, high safety and the like, and provides an efficient and mild new choice for drug treatment of oral ulcer.

The invention discloses mouthwash for treating oral ulcer caused by chemoradiotherapy, which is mainly prepared from the following raw materials in percentage by weight: 0.15 percent to 0.25 percent of chlorhexidine gluconate, 0.015 percent to 0.025 percent of polypeptide of which the amino acid sequence is RWRWRW, 0.05 percent to 0.15 percent of sodium hyaluronate, 0.05 percent to 0.15 percent of menthol, 2.8 percent to 3.2 percent of humectant, 0.45 percent to 0.55 percent of sodium ascorbyl phosphate, 0.5 percent to 1 percent of sodium bicarbonate and the balance of distilled water. The mouthwash for treating the oral ulcer caused by the chemoradiotherapy not only has antibacterial and moisturizing functions, but also can relieve the pain degree of the oral ulcer caused by the chemoradiotherapy, reduce the infection risk and promote ulcer healing, the technical problem that an existing product is single in function is solved, a patient does not need to alternately use multiple preparations, and the compliance is high.

The invention discloses a dammarane type triterpenoid compound or a pharmaceutically acceptable salt thereof. The dammarane type triterpenoid compound has a structural formula as shown in a formula I which is described in the specification. The triterpenoids which are extracted and separated from a gynostemma pentaphyllum medicinal material and have a new chemical structure have an obvious effect of promoting ulcer healing, the application range of gynostemma pentaphyllum can be expanded by developing the triterpenoids into medicines for treating diseases and symptoms related to ulcer, and the utilization value of gynostemma pentaphyllum plant resources is improved. # imgabs0 #

This invention relates to a mouthwash for treating oral ulcers and its preparation method. The mouthwash comprises the following components in the indicated weight ratios: 100 parts deionized water, containing 5-35 parts sodium chloride, 1-10 parts sodium bicarbonate, 0.1-1 parts borneol, 0.1-1 parts peppermint oil, 1-5 parts vitamin E, and 1-5 parts vitamin B12. First, all the above materials (excluding deionized water) are mixed in the indicated weight ratio and ground into a fine powder finer than 400 mesh. Then, peppermint oil is sprayed onto the powder mixture and stirred evenly to obtain the prepared mouthwash powder. The powder is then packaged and sealed. To use, the mouthwash powder is poured into a bottle containing the corresponding weight of deionized water and shaken until fully dissolved before use. This mouthwash has significant effects in treating oral ulcers, providing timely pain relief, accelerating ulcer healing, and shortening the course of the disease.

The invention discloses an application of fennel volatile oil in a medicine for treating pressure sores. The fennel volatile oil is used as a unique active component for preparing the medicine for treating the pressure sores. Through deep research on the pharmacological action of the fennel volatile oil and the treatment effect on a pressure sore animal model, it is proved that the fennel volatile oil can effectively promote healing of pressure sores, and a safer and more effective treatment choice can be provided for pressure sore patients.

A body surface ulcer healing promotion device is provided, which includes: a glucose concentration sensor 11 that detects a glucose concentration in an exudate from an ulcer 2 on a body surface 1; vibrators 21A, 21B, 21C that apply vibration to the ulcer 2; and a control device 31 that controls the vibration of the vibrators 21A, 21B, 21C on a basis of the glucose concentration in the exudate.

This invention belongs to the field of traditional Chinese medicine technology, specifically relating to a herbal antibacterial hydrogel for ulcer healing, its preparation method, and its application. The hydrogel is composed of a herbal composition and a matrix. The herbal composition includes dandelion, angelica, scrophularia, forsythia, phellodendron, atractylodes, angelica dahurica, and raw licorice. The matrix contains chitosan, polyvinyl alcohol, water, and glacial acetic acid. The effective components of the herbal medicine are extracted by decoction, concentrated, and freeze-dried to obtain a freeze-dried powder. This powder is then mixed with a chitosan aqueous solution and cross-linked using a liquid nitrogen cyclic freezing method to form the hydrogel. This invention closely addresses the core pathogenesis of diabetic foot ulcers—"blood stasis, dampness, and heat (toxin)"—allowing the various herbs to synergistically exert their effects of clearing heat and detoxifying, promoting blood circulation and removing blood stasis, drying dampness and astringing sores, and nourishing blood and promoting tissue regeneration. The chitosan matrix endows the hydrogel with good biocompatibility, antibacterial properties, and sustained-release drug properties, which can improve the microenvironment of the ulcer wound, inhibit inflammatory responses, and promote granulation tissue growth, effectively promoting the healing of skin sores such as diabetic foot ulcers, and has broad application prospects.

This application belongs to the technical field of medical dressings, and particularly relates to a microcurrent sponge dressing for promoting pressure ulcer healing and its application. It includes a diaphragm, a cathode sponge, and an anode sponge; the cathode sponge is annularly wrapped outside the diaphragm; the anode sponge is cylindrically distributed inside the diaphragm. In the microcurrent sponge dressing provided by the present invention, the cathode sponge and the anode sponge generate a redox reaction in the wound exudate to produce an electric current; this microcurrent can promote collagen regeneration, and at the same time can generate zinc metal ions with antibacterial effects, which can reduce the risk of wound infection and promote wound healing; in addition, the microcurrent sponge dressing has a three-dimensional porous structure, has excellent water absorption performance, can fully absorb wound exudate, and also has good elasticity, and can provide a buffer layer between the patient and the support surface to reduce the wound surface pressure, ultimately promoting the healing of the pressure ulcer wound surface.

The invention provides a preparation method for promoting transdermal absorption of an externally-applied medicine, an externally-applied medicine composition and application of the externally-applied medicine composition, and the composition comprises multiple traditional Chinese medicine raw materials such as cortex lycii radicis, radix cyathulae and radix astragali and further comprises oat beta-glucan, laurocapram and the like. The radix astragali is processed by a specific honey roasting process, and the Chinese fevervine herb extract is extracted by supercritical CO2. The preparation method comprises the following steps: extracting and concentrating part of medicinal materials to obtain extract, grinding the rest of medicinal materials into powder, adding the powder into the extract, mixing, preparing oat beta-glucan and lecithin into a nano-emulsion, dropwise adding the nano-emulsion into the mixture, adding laurocapram through gradient heating, stirring, and finally adding pearl powder to prepare an external application dosage form. According to the pharmaceutical composition, aiming at complex pathogenesis such as neuropathy, vasculopathy and infection of the diabetic foot, multiple medicinal materials synergistically play a role, drug absorption and utilization are effectively promoted, and the pharmaceutical composition has the effects of clearing heat and cooling blood, tonifying kidney and reducing blood sugar, activating blood and stimulating menstrual flow, dispersing blood stasis and stopping bleeding, promoting ulcer healing, controlling infection, relieving pain, improving neurological functions and the like, and has a wide application prospect. The medicine is suitable for treating diabetic foot through external application.

The invention provides a traditional Chinese medicine composition, a traditional Chinese medicine preparation, a preparation method and application, and particularly belongs to the technical field of traditional Chinese medicine preparation. The traditional Chinese medicine composition comprises the following components in parts by weight: 7-11 parts of champignon, 19-29 parts of aloe, 10-14 parts of fructus chebulae immaturus, 5-7 parts of rhizoma zingiberis, 5-7 parts of rhizoma nardostachyos, 4-6 parts of fructus chebulae and 2-4 parts of halite. The traditional Chinese medicine composition can improve the activity of SOD, inhibit the content of MDA, reduce damage of oxygen free radicals to gastric mucosa, effectively relieve inflammatory response, achieve anti-inflammation, improve ulcer surface blood flow, improve gastric mucosa damage, reduce ulcer surfaces and promote ulcer healing, and therefore the protective effect on gastric ulcer is achieved. The results of network pharmacology, molecular docking speculation and Western blot method verification show that the FMST plays an anti-inflammatory role through a TLR4 / MyD88 / NF-kappa B signal channel.

The invention relates to a traditional Chinese medicine composition for treating ulcerative colitis in a remission stage as well as a preparation method and application of the traditional Chinese medicine composition. The traditional Chinese medicine composition comprises the following traditional Chinese medicine raw materials in parts by weight: 5-35 parts of humifuse euphorbia herb, 3-12 parts of carbonized sanguisorba root, 3-12 parts of gordon euryale seed, 1-6 parts of rhizoma bletillae, 0.5-5 parts of gallnut, 0.06-0.3 part of catechu and 0.02-0.12 part of pearl powder. According to the traditional Chinese medicine, the effects of all the medicines are synergistic, and all the medicines are combined to achieve the effects of attacking evil, tonifying deficiency, clearing waste heat, dispersing blood stasis, stopping bleeding, tonifying spleen and consolidating root; dynamic and static are combined, blood circulation is promoted, stasis is prevented, astringency is induced, and positive consumption is prevented. The multiple medicines synergistically play roles in healing sore, promoting tissue regeneration and repairing intestinal mucosa, directly refer to the core goal of healing ulcerative colitis, and are suitable for the pathogenesis characteristics of gradual decline of damp-heat and spleen deficiency reveal in the remission period of ulcerative colitis.

1. Name of the product in this design: Red Light Rotating Magnetic Therapy Device. 2. Purpose of this design: A therapeutic instrument for the pelvic floor to reduce inflammation, pain, swelling, and promote wound and ulcer healing. 3. The key design feature of this product is its shape. 4. The image or photograph that best illustrates the design's key points: a 3D model.

The invention belongs to the field of traditional Chinese medicines, and discloses a traditional Chinese medicine composition for treating gastric ulcer, which is mainly prepared from the following components in parts by weight: 5 to 20 parts of radix paeoniae alba, 5 to 20 parts of rhizoma atractylodis macrocephalae, 5 to 20 parts of pericarpium citri reticulatae, 5 to 20 parts of radix bupleuri, 5 to 20 parts of poria cocos, 2 to 8 parts of liquorice root, 5 to 20 parts of malt, 5 to 20 parts of radix pseudostellariae, 5 to 20 parts of lily bulb, 2 to 10 parts of folium perillae, 5 to 20 parts of fructus aurantii and 2 to 8 parts of rhizoma zingiberis. The invention further discloses a preparation method of the traditional Chinese medicine composition for treating gastric ulcer and application of the traditional Chinese medicine composition in preparation of a medicine for treating gastric ulcer. According to the traditional Chinese medicine composition, all the medicines are combined to achieve the effects of warming middle-jiao, invigorating spleen and replenishing qi, focus on the pathogenesis of the spleen and stomach deficiency cold syndrome, repair mucosal lesion and promote ulcer healing, and the problems that most patients suffering from the spleen and stomach deficiency cold syndrome suffer from persistent non-healing and repeated attack are solved.

The invention relates to the technical field of medicine, in particular to a GLP-1RA gel preparation for treating diabetic foot ulcer and a preparation method thereof.The preparation is a composition of GLP-1RA and poloxamer temperature-sensitive gel, and poloxamer 407, poloxamer 188 and purified water are sequentially added into a Schottky bottle according to the part ratio of the components of the poloxamer temperature-sensitive gel; placing the Schottky bottle in an ice bath, and fully stirring to obtain a temperature-sensitive gel matrix; liraglutide or loxenatide and the temperature-sensitive gel matrix are stirred and mixed according to the mass ratio, and the GLP-1RA gel preparation is prepared. The GLP-1RA gel preparation is good in biocompatibility, has good elasticity and plasticity, can be tightly attached to a wound, effectively accelerates ulcer repair and shortens ulcer healing time.

The invention belongs to the technical field of medicines, and particularly relates to application of a pharmaceutical composition in preparation of a medicine for treating oral ulcer. According to the application of the medicine composition in preparation of the medicine for treating the oral ulcer, through the synergistic effect of aspirin, acetaminophen and caffeine, the effects of resisting inflammation, easing pain and promoting ulcer healing can be achieved at the same time, the problem that in the prior art, inflammation control and pain relief are difficult to be effectively achieved at the same time is solved, and the medicine composition is worthy of popularization and application. The traditional Chinese medicine composition has the advantages that the oral mucosa inflammatory factors IL-2, IL-6 and TNF-alpha expression conditions can be obviously reduced, epithelial regeneration related pathway genes and expression are promoted to be increased, activated Mmp2 is inhibited, Bcl2 gene expression is increased, cell apoptosis signals are reduced, oral mucosa ulcer is relieved, the inflammatory state of oral ulcer is improved from the molecular level, and ulcer healing is accelerated.

The invention discloses application of a reagent for detecting PGC-1alpha expression in preparation of a product for diagnosing and treating lower limb vein ulcer. The PGC-1alpha is down-regulated in a lower limb vein ulcer case. The invention further discloses application of the PGC-1alpha in preparation of a medicine for treating recurrence of lower limb venous ulcer. Overexpression of the PGC-1alpha can down-regulate expression of inflammatory factors, relieve limb swelling, ulcer healing and pain and relieve tissue edema. According to the application of the PGC-1alpha in preparation of the medicine for treating relapse of the lower limb vein ulcer, expression of the PGC-1alpha protein in patients with the lower limb vein ulcer is reduced, and experiments prove that the PGC-1alpha protein plays an important role in relapse of the ulcer, clinical symptoms, tissue edema and inflammatory response, and the PGC-1alpha protein can be used for preparing the medicine for treating relapse of the lower limb vein ulcer. The PGC-1 alpha protein is expected to become a new target for treating recurrence of the lower limb vein ulcer, and a treatment strategy aiming at the PGC-1 alpha protein possibly becomes an important direction for preventing recurrence of the lower limb vein ulcer in the future.

The present invention belongs to the field of biopharmaceutical materials technology, and specifically relates to a patch with a repairing effect, a preparation method, and applications. The patch comprises the following raw materials: an acidic chitosan solution, a kudzu root powder solution, glycerol, and a polypeptide, wherein the volume ratio of the acidic chitosan solution to the kudzu root powder solution is 1 to 9:9 to 1. The present invention uses chitosan, kudzu root powder, and polypeptide as raw materials, and mixes the polypeptide with a natural composite matrix chitosan / kudzu root powder to prepare a patch with good mechanical properties, excellent biocompatibility, excellent biodegradability, good antibacterial properties, the ability to promote wound healing, and hemostasis. The patch is non-irritating to oral ulcer surfaces, is safe and has no toxic side effects, can adhere to the ulcer surface, and has pain relief, antibacterial, anti-inflammatory, and repair-promoting effects. It can effectively promote ulcer healing, repair and protect wounds from infection, and has excellent biocompatibility and biodegradability. The preparation method is simple and easy to operate.

This invention provides a self-generating ulcer dressing, belonging to the field of medical device technology. The self-generating ulcer dressing comprises a self-generating layer and a conventional ulcer dressing. The conventional ulcer dressing includes a medicated layer and a protective layer, with the self-generating layer either independently between or integrated with both. The self-generating layer is composed of membrane materials such as polylactic acid, polarized cellulose dressing, and polyvinyl alcohol, either alone or in combination with other strongly electronegative biocompatible materials. It generates a Maxwell pulse electric field under external force, accelerating cell regeneration and tissue repair, and promoting ulcer healing. The self-generating layer can be combined with the medicated layer or the protective layer. The protective layer material can be selected from polyacrylic acid resin, diethyl phthalate, or hydroxypropyl methylcellulose, etc. The self-generating ulcer dressing can have a multi-layered or staggered structure, with layers connected by coating, mixing, or compression. The self-generating ulcer patch of the present invention has a flexible design and does not require an external power source. When the self-generating ulcer patch is continuously rubbed and pressed, the self-generating layer is subjected to continuous force to generate a Maxwell pulse electric field and a pulse field current, which can activate cells, promote blood circulation, and work synergistically with ulcer medication to accelerate cell regeneration and tissue repair, thereby achieving the effect of promoting ulcer wound healing.

The present invention provides a device and combination for promoting the healing of ulcers on the body surface. [Solution] A body surface ulcer healing promotion device comprising a glucose concentration sensor 11 for detecting the glucose concentration in the exudate of an ulcer 2 on the body surface 1, vibrators 21A, 21B, and 21C for applying vibration to the ulcer 2, and a control device 31 for controlling the vibration of vibrators 21A, 21B, and 21C based on the glucose concentration in the exudate; and a combination for promoting ulcer healing comprising a vibrator for applying vibration stimulation to an ulcer on the body surface and its vicinity, and a dressing material positioned between the ulcer and the vibrator, wherein the vibration stimulation is performed by vibration of the vibrator via the dressing material.

The invention discloses a traditional Chinese medicine composition for preventing and / or treating oral ulcer, a traditional Chinese medicine preparation and a preparation method and application thereof, and belongs to the field of traditional Chinese medicine. The traditional Chinese medicine composition is prepared from honeysuckle leaves, scutellaria baicalensis, rhizoma et radix baphicacanthis cusiae, lophatherum gracile, radix rehmanniae recen, gallnut and borneol according to a specific ratio through a water extraction, alcohol extraction or water extraction and alcohol precipitation process. The traditional Chinese medicine preparation comprises an effective amount of traditional Chinese medicine composition and pharmaceutically acceptable auxiliary materials. The traditional Chinese medicine composition provided by the invention is suitable for oral ulcer caused by heart and spleen heat accumulation and fire excess from yin deficiency on the basis of the treatment principle of combining heat clearing, detoxifying, yin nourishing and fire lowering, and can effectively relieve pain and swelling symptoms and promote ulcer healing. Experiments show that the traditional Chinese medicine preparation has the effects of resisting inflammation, resisting oxidation and promoting mucous membrane repair, is mild in medicine property and high in safety, and can effectively solve the problem that an existing traditional Chinese medicine preparation for treating dental ulcer is difficult to treat both symptoms and root causes.

The invention belongs to the technical field of medical dressings, and particularly relates to a micro-current sponge dressing for promoting healing of pressure sores and application of the micro-current sponge dressing. The device comprises a diaphragm, a cathode sponge and an anode sponge, the cathode sponge is annularly wrapped outside the diaphragm; and the anode sponge is distributed in the diaphragm in a cylindrical shape. According to the micro-current sponge dressing provided by the invention, the cathode sponge and the anode sponge generate an oxidation-reduction reaction in wound exudate to generate current; the micro-current can promote collagen regeneration, can generate zinc metal ions with an antibacterial effect, and can reduce the wound infection risk and promote wound healing; besides, the micro-current sponge dressing has a three-dimensional porous structure, has excellent water absorption performance, can fully absorb wound exudate, also has good elasticity, can provide a buffer layer between a patient and a supporting surface to relieve wound surface pressure, and finally promotes healing of a pressure sore wound surface.

The invention belongs to the technical field of traditional Chinese medicines, and particularly relates to a spleen-tonifying, middle-jiao-warming and ulcer-healing prescription. The formula comprises 15g of radix astragali preparata, 12g of radix codonopsis, 9g of cassia twig, 15g of poria cocos, 15g of roasted rhizoma atractylodis macrocephalae, 12g of pericarpium citri reticulatae, 9g of ginger processed pinellia, 3g of pseudo-ginseng powder, 9g of cuttlebone, 6g of semen oroxyli, 6g of baked ginger, 6g of rhizoma bletillae and 3g of honey-fried licorice root. The spleen-tonifying, middle-jiao-warming and ulcer-healing prescription has the following effects that (1) the curative effect of the spleen-tonifying, middle-jiao-warming and ulcer-healing prescription combined with rabeprazole on spleen-stomach deficiency-cold type PU is better than that of pure rabeprazole, and the effect of improving the overall clinical symptoms of a patient is more remarkable; and (2) the spleen-tonifying middle-jiao-warming ulcer healing prescription is combined with rabeprazole, so that the prescription is superior to rabeprazole in the aspects of promoting the repair of gastrointestinal mucosa of a spleen and stomach deficiency-cold type PU patient and healing of an ulcer surface. And (3) the spleen-tonifying middle-jiao-warming ulcer healing prescription is combined with rabeprazole, so that the relapse rate of the spleen-stomach deficiency-cold type PU patient is lower than that of rabeprazole.

The invention discloses a traditional Chinese medicine ointment for treating diabetic ulcer and a preparation method thereof, and belongs to the technical field of traditional Chinese medicines and ointment preparation. According to the traditional Chinese medicine ointment, effective components in the traditional Chinese medicine raw materials are extracted and blended into an ointment form through a specific preparation process, and the traditional Chinese medicine ointment is prepared by carefully selecting the traditional Chinese medicine raw materials with the effects of promoting blood circulation to remove blood stasis, clearing away heat and toxic materials, removing slough and promoting tissue regeneration and the like according to the pathological characteristics of diabetic ulcer. The traditional Chinese medicine composition has the effects of resisting inflammation, resisting bacteria and promoting blood circulation and cell regeneration, can directly treat an ulcer surface, and effectively promotes ulcer healing.

The invention relates to a meridian-dredging and healing-promoting decoction for treating diabetic foot ulcer, and belongs to the technical field of traditional Chinese medicine preparation. The formula of the meridian-dredging and healing-promoting decoction comprises a monarch drug, a ministerial drug, an adjuvant drug and a conductant drug, the monarch drug comprises 20g of bombyx batryticatus used for dispelling wind, dredging collaterals, detoxifying and removing stasis; ministerial drugs: 10g of curcuma zedoary used for promoting blood circulation to remove blood stasis, and 15g of oyster used for softening hardness to dissipate stagnation; and adjuvant drugs: 3g of leech used for breaking blood and removing stasis, 10g of bighead atractylodes rhizome used for tonifying spleen and drying dampness, 10g of ligusticum wallichii used for promoting qi to activate blood, and 10g of achyranthes bidentata used for guiding the drugs to move downwards. The traditional Chinese medicine decoction is a clinical effective empirical prescription, accords with the theory of reducing phlegm, removing blood stasis, dredging collaterals and promoting healing in traditional Chinese medicine, improves the vascular function and promotes ulcer healing, the lower limb blood vessels of a patient treated by the decoction are smooth, and ulcer healing is obvious; a multi-target action mechanism can synchronously improve vasculopathy and repair wounds, and the limitation of traditional single-mechanism treatment is broken through; in addition, the traditional Chinese medicine composition is high in safety and especially suitable for long-term bedridden patients and complication patients.