55results about How to "Reduce the effective dose" patented technology

The invention discloses a suspending agent containing chlorantraniliprole and lambda-cyhalothrin. The suspending agent is mainly applied to control of insect pests on crops. The lambda-cyhalothrin is low in melting point, so that dosage form of the lambda-cyhalothrin at present is mainly emulsified after being dissolved, and is mainly missible oil, a microemulsion and an emulsion in water, but the three dosage forms contain benzene organic solvents, and are not environmental dosage forms in true sense. By adopting the suspending agent, the complex suspending agent of the chlorantraniliprole and the lambda-cyhalothrin is introduced, does not contain an organic solvent, does not contain carcinogenic, teratogenic or mutagenic agents, and is the environmental dosage form in true sense. The composition comprises the main effective components of 1-20% of chlorantraniliprole, 1-10% of lambda-cyhalothrin, 3-6% of dispersing agent, 1-2% of wetting agent, 1-2% of stabilizer, 0.1-0.2% of defoamer, 0.2-5% of suspending agent, 3-5% of antifreezing agent and the balance of water. The insecticidal compound suspending agent belongs to an environment-friendly pesticide, is free of three wastes in production, and is convenient to use.

The invention relates to application of clausena lansium leaves to preparation of alpha-glucosidase inhibitor products. The clausena lansium leaves are dried leaves of a rue family clausena plant clausena lansium (Lour.) Skeels. The invention further provides a composition with an alpha-glucosidase activity inhibiting effect. The composition comprises a clausena lansium leaf raw medicinal material or medicinal slices or extract of the material and other traditional Chinese medicinal materials such as coptis chinensis, panax ginseng and safflower carthamus. The composition or a preparation of the composition can be used for inhibiting the alpha-glucosidase activity, and reducing or assisting in reducing postprandial blood sugar or preventing and/or treating obesity clinically. The composition can be used as health-care food or food, and is high in safety. The preparation method is simple, and the product with the clinical effect can be obtained by adopting a conventional extraction and separation technology.

The invention discloses a preparation method of endogenous interferon inducer injection and nanometer microencapsulation solution, relating to a pharmaceutical composition for treating and curing breeding animal viral infection by improving the inducement level of endogenous interferon. The invention uses endogenous interferon induction technology, avoids the defects of strong specificity of self species of interferon preparation, is convenient to apply in production and practice by drug administration in various modes and has the characteristics of low onset dose and the like, and degradation products can directly enter an animal body metabolic pool to continue metabolizing. In addition, the invention has an important meaning for effectively controlling raised animal viral infection and lowering drug residue harm.

The invention relates to the field of medicine and discloses a pharmaceutical composition and application of the same in preparation of medicines used for treating cerebrovascular diseases. The pharmaceutical composition comprises trans-3-[4-(1H-imidazole-1-ylmethyl)phenyl]-2-sodium acrylate and 2-borneol.

The invention relates to a pharmaceutical composition for nerve regeneration after cerebral arterial thrombosis as well as a preparation method and application thereof, and the pharmaceutical composition for nerve regeneration after cerebral arterial thrombosis is provided for solving the problem of strong hepatotoxicity of existing chemical treatment medicaments for ischemic cerebrovascular disease. The pharmaceutical composition is prepared from the following raw materials: 15 parts of akebiaquinata, 6 parts of codonopsis pilosula, 10 parts of pomegranate bark, 10 parts of shiny-leaved yellowhorn shell, 10 parts of thunberg fritillary bulb, 20 parts of sealwort, 20 parts of the root of red-rooted salvia, 10 parts of glabrous sarcandra herb, 5 parts of ligusticum wallichii, 8 parts of seed of feather cockscomb, 15 parts of the root of fangji, 7 parts of burdock, 10 parts of the root of kudzu vine, and 10 parts of liquorice. The pharmaceutical composition can be used for promoting nerve regeneration after cerebral arterial thrombosis, so as to cure or prevent cerebral ischemia or cerebral infarction.

The invention relates to a disinsection sprinkling oil concentrate, which mainly composed of components with the following mass content: 40 to 65 percent of liquid paraffin, 2 to 5 percent of jinggangmycin, 1 to 3 percent of avermectin, 2 to 10 percent of tea saponin, 0.5 to 2 percent of water soluble extractive of plocamium telfairiae harv, 0.5 to 6 percent of water soluble extractive of tobacco leaves, 1.5 to 3 percent of emulsifier and the balancing amount of water; the emulsifier is mixture of sapn and tween with the mass ratio of 3: 1. The disinsection sprinkling oil concentrate of the invention has broad spectrum bacteriostasis and sterilization effect, quick action and long action are combined together, an efficacy period of 35 days can be maintained, no toxicity can be left on human and livestock, the environment can not be polluted, the effective drug consumption can be reduced, the generation of drug fastness can be suspended, and thereby the disinsection sprinkling oil concentrate can be used for the disinsection and the prophylaxis to fruits, vegetables, garden flowers, lawns, and urban gardens and trees.

The invention discloses a traditional Chinese medicine gel cream for treating a local rheumatic pain syndrome and a preparation method thereof. The traditional Chinese medicine gel cream comprises a backing layer, a cream layer containing the traditional Chinese medicine and a cover lining, the cream layer containing the traditional Chinese medicine is prepared from, by weight, 1-5 parts of medicine extract, 1-5 parts of fine stuff, 20-30 parts of skeleton materials, 10-15 parts of agglutinants, 40-50 parts of humectant, 3-6 parts of filler, 0.2-0.5 part of a cross-linking agent and 0.3-0.6 part of a crosslinking accelerator. According to the traditional Chinese medicine gel cream for treating the local rheumatic pain syndrome and the preparation method thereof, the prepared traditional Chinese medicine gel cream has no stimulation and allergic reaction to skins, the adhesive force is good, anti-inflammatory and analgesic functions are achieved, the effect appears earlier, the dosage is low when the effect appears, the therapeutic effect is good, and the traditional Chinese medicine gel cream can be produced on a large scale.

The invention belongs to the technical field of natural medicine, and particularly relates to a flowering day lily extract, a preparation method and usage of the flowering day lily extract, and an antidepressant drug combination. The invention discloses the simple, economic and environment protective preparation method of the flowering day lily extract, and products of the preparation method, andfurther discloses application of the flowering day lily extract to preparation of antidepressant drug, and the antidepressant drug combination taking the flowering day lily extract as an active substance. The usage is verified through pharmacology experiment. According to the flowering day lily extract, the preparation method and usage of the flowering day lily extract, and the antidepressant drugcombination, application value of the flowering day lily is greatly developed, an intestinal microbial metabolites hypothesis is firstly adopted and applied to the flowering day lily extract, it is indicated that the flowering day lily extract can obviously influence intestinal microbe of a mice for treating depression, and good application prospects are achieved.

The invention is suitable for the technical field of pesticide preparations and provides a cyantraniliprole and chlorfenapyr suspending agent and a preparation method thereof. The cyantraniliprole and chlorfenapyr suspending agent comprises the following components in percent by mass: 1%-50% of cyantraniliprole, 1%-50% of chlorfenapyr, 2%-10% of a dispersing agent, 1%-5% of a wetting agent, 0.2%-1% of a de-foaming agent, 0-10% of an anti-freezing agent, 0.1%-5% of a thickening agent, 0.1%-2% of a mildew preventive, 0-2% of a PH regulator and the balance of deionized water. The cyantraniliprole and chlorfenapyr suspending agent disclosed by the invention has the characteristics such as small preparation particles, narrow particle diameter distribution, long-term stable storage, no precipitation and extremely small water bleeding amount, can increase the utilization rate of active ingredients and can avoid pollution of normal preparations on environment; besides, the preparation process is simple and environment-friendly.

The invention discloses a 4-methylpyrrole substituted indolone derivative, and a preparation method and medical application thereof. The invention relates to the field of medicinal chemistry. Comparedwith a compound 10d discovered in the earlier stage, the 4-methylpyrrole substituted indolone derivative disclosed by the invention has better chemical stability, higher selectivity on FLT3-ITD, moreideal pharmacokinetic characteristics and stronger in-vivo anti-tumor activity, and particularly has lower effective dose for treating acute myeloid leukemia. Under the same dosage, the tumor inhibition rate is obviously superior to that of compounds 10d and sunitinib, and the drug resistance is not easy to generate.

The invention discloses a lepidoptera insect insecticide synergist. Active ingredients of the lepidoptera insect insecticide synergist include iso-ascaridole, alpha-terpinene and germacrene B, a mass concentration ratio of the iso-ascaridole to the alpha-terpinene to the germacrene B in a solvent is 1-20:1-10:1-15, and the active ingredients can be extracted from dysphania ambrosioides or chenopodium aristatum. When the insecticide synergist is used for killing lepidoptera insects, a volume percentage concentration of the iso-ascaridol, the alpha-terpinene and the germacrene B in an insecticide is 1-15%. According to pharmacodynamic tests, insecticide efficacies can be remarkably improved by consumption of a small quantity of the lepidoptera insect insecticide synergist, and insecticide consumption can be reduced by 20-45% under equal control effects, so that insecticide consumption is effectively reduced, drug resistance of harmful organisms is overcome and weakened, environment pollution is reduced, and remarkable economic benefit and environment protection significances are achieved.

The invention relates to an application of salacia prinoides in preparation of a glycogen phosphorylase inhibitor product. The salacia prinoides preferably selects dried stems of salacia prinoides (Wild.)DC. The invention also provides a composition capable of inhibiting activity of glycogen phosphorylase, which takes an original medicinal material or its decoction pieces or its extract product as an active component, and a pharmaceutically acceptable auxiliary material is added. The composition or its preparation can be used for inhibiting activity of glycogen phosphorylase, and clinically used for preventing and/or treating type II diabetes. The product can be taken as health food or food, and has high security. The preparation method is simple, and the production having the clinical curative effect is obtained by employing a conventional extraction separating technology.

The invention relates to application of a pyridine sulfonamide phosphate compound or a pharmaceutical composition containing the pyridine sulfonamide phosphate compound in preparation of an anti-encephaledema drug. The pyridine sulfonamide phosphate compound can quickly reduce intracranial pressure, is used for treating encephaledema caused by various reasons and preventing cerebral hernia, is high in safety, has no serious adverse effects such as liver and kidney injury and the like, is expected to become a novel clinical anti-encephaledema medicine, and has a very wide clinical application prospect.

The invention discloses a bupirimate.boscalid suspoemulsion and a preparation method thereof. The bupirimate.boscalid suspoemulsion is prepared from the following components in percentage by weight according to a formula: 5-20 percent of bupirimate and 5-20 percent of boscalid. According to the bupirimate.boscalid suspoemulsion and the preparation method disclosed by the invention, by compounding the bupirimate and the boscalid and adopting a reagent form of suspoemulsion, the two active ingredients have synergistic interaction, so that the sterilization treatment spectrum action is enlarged, the effect of controlling germs is remarkably improved, the drug resistance problem of the germs is relieved, the therapeutic effect on diseases including powdery mildew, botrytis cinerea, sclerotinia and various rot diseases of crops including rapes, grapes, fruit trees, vegetables and field crops is good, the dosage form is environmentally friendly, and pollution and damage to the environment are reduced.

The invention discloses preparation of a compound of Au and an anti-apoptotic protein antagonistic peptide and application of the compound in synergistic induction of tumor cell apoptosis, and relates to the field of anti-tumor drugs. Mixing a gold salt solution with the anti-apoptotic protein antagonistic peptide containing sulfydryl; under the conditions of certain temperature and pH, redox reaction is carried out, high-valence Au ions are reduced into Au atoms or monovalent Au ions, and Au acts on sulfydryl of polypeptide to form a compound AuP; the sulfydryl-containing anti-apoptotic protein antagonistic peptide is selected from polypeptides with an intracellular anti-apoptotic protein antagonistic function. The AuP compound has broad-spectrum anti-tumor activity, and compared with a common peptide-gold compound or gold compound, the AuP compound can inhibit the activity of thioredoxin reductase and antagonize the function of high-expression anti-apoptotic protein at the same time, the single-drug double-target synergistic effect is achieved, and the curative effect is remarkably improved. The compound can be used for treating various malignant tumors such as chronic lymphocytic leukemia, acute monocytic leukemia and non-Hodgkin lymphoma.

The invention relates to an insect repellent agent for flower planting and a preparation method of the insect repellent agent. The insect repellent agent is prepared from raw materials in parts by weight as follows: 20-25 parts of tobacco waste, 15-20 parts of branches and leaves of tea trees, 15-20 parts of cortex meliae, 10-15 parts of shells of bamboo shoots, 10-15 parts of branches and leavesof gingkoes, 8-12 parts of Chinese honeylocust fruits, 5-10 parts of radix euphorbiae lantu, 4-8 parts of wormcast, 3-6 parts of plant ash and 2-5 parts of auxiliaries. The insect repellent agent prepared with the method is good in control effect and long in lasting period, has low probability of producing insecticide resistance, is green, pollution-free and harmless to body health and cannot pollute the environment; the preparation method is simple and easy to operate, the cost is low, efficacy of the insect repellent agent can be remarkably improved, effective dosage is effectively reduced,insecticide resistance of harmful organisms is overcome and delayed, the application range of the insect repellent agent is wide, potential value of plant resources is sufficiently utilized, and the insect repellent agent has remarkable economic benefit and environmental protection significance.