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New application of clausena lansium leaves

A technology of wampum leaves and composition, which is applied in the field of medicine, can solve the problems of prevention and treatment of postprandial hyperglycemia or obesity, and achieve the effects of good drug development prospects, wide distribution, and simple preparation methods

Inactive Publication Date: 2015-11-04
周亚伟
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] Although the aforementioned prior art discloses that the leaves of the yellow skin and the coumarin compounds isolated from the leaves of the yellow skin have a hypoglycemic effect, there has been no research report on the activity of the leaves of the yellow skin on inhibiting the activity of α-glucosidase. There is no relevant report on its application in the prevention and treatment of postprandial hyperglycemia or obesity

Method used

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  • New application of clausena lansium leaves
  • New application of clausena lansium leaves
  • New application of clausena lansium leaves

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0065] The preparation of embodiment 1 yellow bark leaves water crude extract

[0066] Take the dry leaves of wampum, crush them, weigh about 20g, extract three times with 10 times the amount of water, the extraction time is 1h, 0.5h, 0.5h respectively, combine the extracts, concentrate under reduced pressure to 10ml, the specification is 2:1 ( g / ml).

Embodiment 2

[0067] The preparation of embodiment 2 yellow bark leaves ethanol crude extract

[0068] Take the dried leaves of Cortex japonica, crush them, weigh about 20g, extract three times with 10 times the amount of 95% ethanol, the extraction time is 1h, 0.5h, and 0.5h respectively, combine the extracts, concentrate under reduced pressure to 10ml, and the specifications are 2: 1 (g / ml).

Embodiment 3

[0069] The preparation of the original medicine capsule of embodiment 3 Huangpi Ye

[0070] Take the dry leaves of wampum, pulverize according to the conventional method, sieve, sieve and get 60-80 mesh wampes leaf fine powder, put the fine powder into capsules, sterilize, and pack separately.

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Abstract

The invention relates to application of clausena lansium leaves to preparation of alpha-glucosidase inhibitor products. The clausena lansium leaves are dried leaves of a rue family clausena plant clausena lansium (Lour.) Skeels. The invention further provides a composition with an alpha-glucosidase activity inhibiting effect. The composition comprises a clausena lansium leaf raw medicinal material or medicinal slices or extract of the material and other traditional Chinese medicinal materials such as coptis chinensis, panax ginseng and safflower carthamus. The composition or a preparation of the composition can be used for inhibiting the alpha-glucosidase activity, and reducing or assisting in reducing postprandial blood sugar or preventing and / or treating obesity clinically. The composition can be used as health-care food or food, and is high in safety. The preparation method is simple, and the product with the clinical effect can be obtained by adopting a conventional extraction and separation technology.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to the new application of leaves of wampum bark as an α-glucosidase inhibitor, which can be used to prevent and / or treat diabetes or obesity. Background technique [0002] For many years, sulfonylureas and biguanides have been the main drugs used to treat diabetes clinically. In animal experiments, sulfonylureas only lowered blood sugar in normal mice, but were ineffective for alloxan hyperglycemic mice; biguanides Because of increasing the anaerobic glycolysis of sugar, similar drugs can cause different degrees of increase in blood lactic acid, and sometimes even cause serious consequences of blood lactic acidosis in patients. Although both have good effects on lowering fasting blood sugar, their effect on lowering postprandial blood sugar is very limited. Postprandial blood sugar in diabetes is the highest stage of blood sugar level in a day, and its duration can be as long as 8...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/75A61K36/8969A61K36/8968A61K36/8964A61K36/815A61K36/804A61P3/10A61P3/04A23L1/29A61K35/62A61K127/00A23L33/00
Inventor 周亚伟
Owner 周亚伟
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