58 results about "Blood lactic acid" patented technology

Disclosed is an anticancer pharmaceutical composition comprising phenformin or a pharmaceutically acceptable salt thereof, and a glycolysis inhibitor, particularly, 2-deoxy-D-glucose as active ingredients. These ingredients act in synergy with each other, thus exhibiting more potent inhibitory activity against the growth of cancer cells, compared to individual ingredients. Also, the synergistic anticancer activity allows the individual drugs to be used in lower amounts, which leads to a reduction in the occurrence of adverse effects. In addition, the time-lag release or administration of the ingredients decreases blood lactic acid levels to significantly mitigate the adverse effect of lactic acidosis, as well as exerting high anticancer effects. Particularly, the pharmaceutical composition can be formulated to dosage forms effective for therapy, increasing the drug compliance of the subject.

Disclosed is an anticancer pharmaceutical composition comprising phenformin or a pharmaceutically acceptable salt thereof, and 2-deoxy-D-glucose as active ingredients. These ingredients act in synergy with each other, thus exhibiting more potent inhibitory activity against the growth of cancer cells, compared to individual ingredients. Also, the synergistic anticancer activity allows the individual drugs to be used in lower amounts, which leads to a reduction in the occurrence of adverse effects. In addition, the time-lag release or administration of the ingredients decreases blood lactic acid levels to significantly mitigate the adverse effect of lactic acidosis, as well as exerting high anticancer effects. Particularly, the pharmaceutical composition can be formulated to dosage forms effective for therapy, increasing the drug compliance of the subject.

The invention relates to anti-fatigue anti-aging compound capsules containing sea cucumber peptides and oyster peptides. The components in each 500mg of capsule contents are as follows: 200-300mg of sea cucumber peptides, 100-200mg of oyster peptides, 50-100mg of maca extractive, 50-100mg of polygonatum sibiricum rhizome extractive, and 5-10mg of astaxanthin. A preparation method comprises weighing raw materials according to proportioning, conducting uniform mixing, conducting sieving with a 100-mesh sieve to obtain mixed powder, and then filling capsule shells with the obtained compound powder by adopting a conventional capsule filling process so as to obtain the compound capsules. The compound capsules prepared by the invention can prolong the weight-bearing swimming time of mice, reducethe blood lactic acid level of the mice after exercise, and increase hepatic glycogen reserve of the mice; and the compound capsules have obvious protection effect on the damage caused by oxidation in the mice of a rapid aging model. Through human test-meal trials, the compound capsules can obviously relieve fatigue symptoms including fatigue, hypodynamia, soreness of waists and legs, and sexualhypofunction. The trials indicate that the compound capsules have good anti-fatigue and anti-aging effects, and have no side effect on human bodies, and can be taken for a long term.

The invention discloses a method for detecting blood lactic acid in vitro by using a chemiluminescence method, which is characterized in that LD is utilized to catalyze L-lactic acid and NAD<+> to generate pyruvate and NADH, the pyruvate and ADP generate ATP under the catalysis of pyruvate kinase (PK), ATP and glycerol generate glycerol-3-phosphoric acid and ADP under the catalysis of GK, the glycerol-3-phosphoric acid is acted by GPO to obtain H2O2, and H2O2 is catalyzed by HPR to enable luminol to emit light; the size of light signals is in positive correlation with the concentration of thepyruvate, i.e. the bigger the concentration of the lactic acid is, the stronger the emitted light signals are; the concentration of the lactic acid can be conjectured by recording the light signals; and the lactic acid with the known concentration is used for detecting the light signals to make a dose-response curve, and the content of the lactic acid of an unknown sample can be calculated throughthe curve. In the invention, a chemiluminescence substance replaces a colored substance to achieve the purposes of sensitivity, stability, wide range and safety. The method can be used for preparinga corresponding commercial kit for quantitatively detecting the lactic acid in body fluids such as whole blood, plasma, cerebrospinal fluid, urine, gastric juice and the like.

The present invention provides a sports milk and its production method. Said invention uses the milk as carrier of nutrients, and uses serum protein to raise protein content, and adds the bio-active peptide and SOD so as to make the sports milk possess the functions of inhibiting blood lactic acid increment, raising immunity, preventing fatigue and hyperkinetic syndrome and promoting restoration after sports.

The invention relates to a composition for relieving exercise induced fatigue and a preparation of the composition. The composition comprises the following components in parts by weight: 20-90 parts of folium cortex eucommiae extracts and 10-60 parts of American ginseng. The composition has the beneficial effects that the content of chlorogenic acid in the folium cortex eucommiae extracts is greater than or equal to 25%, the chlorogenic acid has favorable functions of scavenging free radical and resisting oxidation and the anti-fatigue mechanism is related to the antioxidation property; the American ginseng in the composition contains American ginseng saponin, the content of which is greater than or equal to 8%. Through the compatibility of the folium cortex eucommiae extracts and the American ginseng, the heart rate and blood lactic acid level after the exercises can be effectively reduced so that the anti-fatigue role is played; the prepared product is convenient to carry and simple to eat. The natural plant elements are scientifically extracted and dried, so that the packaged product is easy to carry. The composition can be eaten in various manners and is simple in method.

The invention relates to a preparation method of deer blood peptide and its anti-fatigue effect, belonging to the field of medicine. Drying of deer blood: use a spray dryer, adjust the inlet temperature to 180°C, the outlet temperature to 80°C, and the speed to 26,000-30,000 rpm; deer blood protein hydrolysis: the concentration of deer blood protein is 3%, and alkaline protease is used for hydrolysis , The hydrolysis conditions are: temperature 53°C, time 5.5h, pH 9.5, enzyme amount 1272u/g; purification of deer blood peptide: membrane filtration and gel chromatography. In the present invention, the anti-fatigue experiment of mice is used to study the activity of the deer blood peptide. Animal experiments show that the polypeptide produced by the optimal hydrolysis process can significantly prolong the swimming time and low-pressure hypoxia tolerance of mice, the content of liver glycogen is significantly higher than that of the control group, and the content of blood lactic acid is significantly lower than that of the control group; It has good anti-fatigue effect.

The invention relates to a composition used for physical recovery, and its application. Raw materials of the composition comprise puffed black rice powder, coconut oil, glucose, soybean protein powder, branched chain amino acids, low fat cocoa powder and a vanilla essence. The composition used for physical recovery can improve the blood sugar content of bodies after exercise, maintain the blood sugar content of bodies during continuous exercise, delay the exercise fatigue of the bodies, reduce the blood lactic acid content of the bodies after exercise, improve the exercise endurance ability of the bodies, quickly replenish energy and rapidly enhance the state of the body, is suitable for the rapid supplementation of energy, electrolyte and other nutrients needed by army officers and soldiers, various rescue workers, sports people, outdoor adventure people or tourists, and is helpful for rapidly improving the exercise and response ability of the bodies. The composition has the characteristics of good mouthfeel and rapid effectiveness, and all components of the composition are foods, so no toxic side effects are caused after long term eating. Each 60g of the composition used for physical recovery comprises 36.8g or more of total sugar, 2.4g or more of fat and 7.4g or more of protein, and the calorific power of 60g of the composition is not lower than 225kcal.

The invention discloses Lactobacillus plantarum WZMX-2 as well as application and prepared whey pear wine thereof. Bitter-free whey pear wine is prepared by the following steps: uniformly mixing whey fermentation liquor composed of Lactobacillus plantarum WZMX-2, Kluyveromyces marxianus WWMJ-1 and saccharomyces cerevisiae at the volume ratio of 4:4:2 with whey bergamot pear juice mixed liquor; culturing at 25-37 DEG C for 24-72 hours; and fermenting when measuring that the alcohol degree reaches 7.8% vol, the total acid reaches 60.84 titration acidity, the total sugar content reaches 42.34 g/L, and the bitter peptide content reaches 0.15 g/100 mL. The prepared whey pear wine is yellowish green, clarified and translucent, has natural color and fragrance of whey and pear, and has no bitter feeling; functional tests prove that the prepared whey pear wine can prolong weight-bearing swimming time of mice, reduces the generation of serum urea, increases the reserve of liver glycogen, has no apparent influence on weight and blood lactic acid of the mice, and has a functional effect of alleviating physical fatigue.

The invention discloses a handheld type multi-parameter on-site fast biochemical detector, which relates to the technology of human body detection and comprises a multi-channel detecting circuit, a work voltage generating circuit, a power circuit, a bluetooth module, a display module, a single chip microprogrammed control unit (MCU), a fixing part embedded in a single chip and various detecting strips matched with the fixing part for use. The detector can automatically identify various detecting strips to achieve the following functions: 1 simultaneous detection of three parameters of blood sugar, blood lactic acid and a blood ketone body; 2 simultaneous detection of any two of the parameters; and 3 detection of any one parameter. The detector can automatically and fast finish detection and output detection results. The bluetooth module is built in the detector and can automatically send the detection results in wireless mode. The simultaneous detection of the three parameters can effectively reduce bleeding amount and suffering of a testee. Simultaneously, the multi-parameter biochemical detector further has the advantages of automatic and fast detection, convenience in carry, long standby time, wireless data transmission and the like.

The present invention relates to a fatigue preventing health-care composition. The composition comprises the following raw materials: Chinese wolfberry fruits, red dates, maca, radix puerariae, American ginsengs, L-carnitine, taurine, selenium-enriched yeast and SOD freeze-dried powder. A preparation method of the composition is as follows: firstly the Chinese wolfberry fruits and red dates are subjected to extraction with water, a water extract is concentrated, the concentrated extract is dried, the dried extract is crushed to obtain powder A; then the maca, radix puerariae and American ginsengs are subjected to extraction with ethanol, an alcohol extract is concentrated to obtain an alcohol extract thick paste, medicinal dregs after the alcohol extraction are boiled with water, the water decoction is concentrated, the concentrated water decoction is mixed evenly with the alcohol extract thick paste, the mixture is dried, and the dried mixture is crushed to obtain powder B; and finally, the powder A, the powder B and other raw materials in the formula are mixed evenly to obtain the fatigue preventing health-care composition. The prepared health-care composition can obviously prolong the weight-bearing swimming time of mice, reduces the blood lactic acid level of the mice after exercises, and increases the reservation of hepatic glycogen in the mice. Through population eating trials, the composition can obviously alleviate or improve the fatigues, sore waist and painful legs, sexual dysfunction and other symptoms.

The invention discloses a lycium barbarum polysaccharide-deer blood composition having functions of relieving fatigue and tonifying yang. Lycium barbarum polysaccharide and a deer blood dry powder asactive components are made into an oral preparation in accordance with conventional excipients and processes of the pharmaceutics, or are made into a food prepared for a meal in accordance with a health-care food process. Experiments show that the composition can significantly prolong the loaded swimming time of small mice, reduce the content of blood lactic acid and serum urea nitrogen after thesmall mice do exercise and increase the reserve amount of hepatic glycogen; compared with the fatigue relieving function of the single use of lycium barbarum polysaccharide and deer blood, the function is more comprehensive, and the effect is more effective. The composition also can significantly enhance the gonadal hormone level of rats and the activity of superoxide dismutase in testis tissues,reduces the content of malondialdehyde, enhances the antioxidant capacity of the rat, and has stronger activity than the activity of lycium barbarum polysaccharide and deer blood groups. Therefore, the composition can be used for enhancing the anti-fatigue and yang-tonifying ability of sub-health young and middle-aged men, as well as conditioning middle-aged and elderly patients with physical deficiency.

The invention relates to a health-care food for relieving fatigue which is prepared by mixing ginseng, Chinese wolfberries, rhizoma atractylodis macrocephalae and coffee beans. The preparation method comprises the following steps: extracting ginseng by ethanol to obtain a thick paste A; decocting the Chinese wolfberries, rhizoma atractylodis macrocephalae and coffee beans with water to obtain a thick paste B; and mixing the thick pastes A and B, drying the pastes at a reduced pressure, and smashing the pastes to fine powder. By combining the above four matters, from the aspect of the characteristics of tonifying Qi, tonifying liver and kidney, enriching yin, tonifying spleen and inducing resuscitation, a synergic function of relieving physical fatigue is realized. The health-care food provided by the invention can prolong the load-bearing swimming time of a mouse, reduce the blood lactic acid area of the body caused by fatigue, reduce the content of urea nitrogen in blood and meanwhile, increase the number of autonomic activities of the mouse.

The invention discloses anti-fatigue silk acupuncture cotton which comprises a silk layer, wherein a germanium ion fiber layer is also arranged on the silk layer; and the silk layer and the germanium ion fiber layer are acupunctured together. Apart from the characteristics of common silk acupuncture cotton, the anti-fatigue silk acupuncture cotton can reduce the blood lactic acid value in the human blood, and has functions of helping people in refection and fatigue resistance.

The full blood lactic acid biosensor modified with oriented carbon nanotube features that one layer of Co particles as the catalyst for oriented growth of carbon nanotube is deposited on the substrate and that the reaction layer has base layer comprising oriented carbon nanotube as the second electric intermediate and the upper layer comprising L-lactic oxidase and the mixture of reagent, stabilizer and buffering liquid as the first electric intermediate. Compared with available the technology, the present invention has the advantages of obviously raised responding sensitivity on lactic acid concentration of the sensor, work voltage of the sensor lowered from 500 mv to 300 mv, no need of pre-treatment of the blood sample and blood sample amount as less as 2 microliter.

The invention relates to a liquiritigenin-cyclodextrin or cyclodextrin derivative clathrate, a composition containing the clathrate, and a preparation method and novel application of the clathrate; the application of the liquiritigenin-cyclodextrin or cyclodextrin derivative clathrate in the preparation of drugs for improving or treating exercise-induced fatigue, and the pharmaceutical composition are prepared by the inventor during the study on the liquiritigenin-cyclodextrin or cyclodextrin derivative clathrate by: establishing an animal model, and detecting change levels of hepatic glycogen, blood lactic acid and urea nitrogen in a mouse sample; it is verified that liquiritigenin can resist exercise-induced fatigue, and the pharmaceutical composition for resisting exercise-induced fatigue is prepared.

The invention discloses a composition for remarkably improving the anti-fatigue function, and a preparation method and an application thereof. The composition comprises, by weight, 24-48 parts of a Haematococcus pluvialis solid dispersion, 900-2500 parts of Lepidium meyenii Walp, 100-600 parts of taurine and 140-320 parts of acai berry powder, wherein the mass percentage content of astaxanthin in the Haematococcus pluvialis solid dispersion is 2.0-3.0%, the Lepidium meyenii Walp undergoes heat refluxing extraction by using ethanol to prepare extract containing 0.02-0.05% by mass of macamides and 5-9% by mass of polysaccharides, and the acai berry powder is prepared through pulping, filtering for residual removal, and spray drying of fresh acai berries. A test result shows that the composition can remarkably prolong the load swimming time of load swimming mice, obviously improve the liver starch level of the mice and remarkably reduce the area under the blood lactic acid curve and the serum urea nitrogen content of the mice after the swimming, and has a good physical fatigue alleviation effect.

The present invention discloses a lactic acid reducing device for handling lactic acid accumulation and control method thereof. The lactic acid reduction device comprises a cabin body, a seat, a controller, hydrogen production equipment, an electric heating device, a light therapeutic instrument, a lactic acid detection device and a power supply device; the seat is installed at the bottom of the cabin body, the controller and the power supply device are installed outside the cabin body, and the hydrogen production equipment is installed outside the cabin body. The hydrogen equipment generates hydrogen and conveys the hydrogen into the cabin body through a hydrogen pipe, the electric heating device, the light therapeutic instrument and the lactic acid detection device are all installed in the cabin body, and the hydrogen production equipment, the electric heating device, the light therapeutic instrument and the lactic acid detection device are all connected with the controller. The lactic acid detection device is used for detecting the accumulation condition of lactic acid in a human body, hydrogen production equipment, the electric heating device and the light therapeutic instrument are combined through various physical means, blood lactic acid metabolism of the human body is accelerated, lactic acid accumulation is eliminated, and free radicals generated in exercises are effectively removed.

The invention discloses a health food capable of rapidly eliminating exercise-induced fatigue and improving sport performance for athletes, which comprises the following raw materials by weight: 300 parts of spirulina, 30-20 parts of bee pollen, 20-30 parts of black matrimony vine and 10-20 parts of American ginseng. The invention also discloses a preparation method of the health food. The health food takes spirulina as a main material with maximum amount, so that motor function can be completely increased, the blood lactic acid value is reduced, and the anoxic motion capability is increased; and the health food takes bee pollen and matrimony vine as auxiliary materials, the bee pollen mainly reduces the content of blood urea nitrogen, so that the aerobic exercises capability is enhanced, black matrimony vine can enlarge oxygen consumption and mainly enhance cardiac vessels function and rapidly alleviate fatigue; the American ginseng is added for enhancing the flavor of the above materials, and has promotion effect for reducing lactic acid and urea nitrogen and enhancing cardiac vessels function. The health food provided by the invention has the effects of minimizing lactic acid accumulation after motion, reducing urea nitrogen value after motion, rapidly eliminating exercise-induced fatigue, increasing motor function and improving sport performance for athletes.

The invention relates to an anti-fatigue ethanol extract of floriferous bacopa monnieri, a method for preparing the anti-fatigue ethanol extract and application thereof. The anti-fatigue ethanol extract, the method and the application have the advantages that anti-fatigue effects of the floriferous bacopa monnieri which is traditional Chinese medicine are observed via loaded-swimming fatigue models of mice, as proved by results, the loaded-swimming time of the mice can be obviously prolonged by the extract, the contents of blood lactic acid and serum urea nitrogen in the bodies of the mice can be reduced after the mice exercise, reserved hepatic glycogen further can be increased, and the exercise tolerance can be improved; the anti-fatigue effects can be realized by the extract of the floriferous bacopa monnieri, the fatigue degrees of human bodies can be obviously relieved by the extract, and the extract can be used for producing and processing food or healthcare products.

The invention relates to applications of macrolide antibiotics, especially Erythromycin, in preparation of anti-fatigue disease medicines. The anti-fatigue function of macrolide antibiotics, especially Erythromycin is discovered firstly, animal test results show that macrolide antibiotics can prolong swimming time of mice bearing load greatly, lower the serum urea ammonia level after strenuous exercise, inhibit rise of blood lactic acid, keep or increase the content of ferrohemoglobin, raise lactate dehydrogenase activity, raise liver starch reserve, reduce liver starch consumption during exercise, and have functions of alleviating fatigue and increasing exercise endurance greatly.

An isolated lactic acid bacteria strain: Bifidobacterium longum subsp. longum OLP-01 strain for increasing exercise performance and ameliorating fatigue is disclosed. A variety of animal experiments have proved that OLP-01 not only effectively improves muscle strength and swimming endurance but also significantly reduces fatigue-related biochemical indicators, including blood lactate, blood urea nitrogen and the activity of creatine kinase.

The invention discloses application of lycium barbarum polysaccharide in preparation of anti-fatigue drugs, health care products or food. The lycium barbarum polysaccharide with the molecular weight of 92.4 kDa can obviously increase the reserve of hepatic glycogen and muscle glycogen, improve the activity of superoxide dismutase and obviously reduce the levels of serum urea nitrogen, blood lactic acid and malondialdehyde; and compared with lycium barbarum polysaccharide with other molecular weights, the lycium barbarum polysaccharide has a more excellent anti-fatigue effect and is suitable for preparing anti-fatigue drugs, health care products or food.

The invention belongs to the field of healthcare products, and particularly relates to Folium Artemisiae Argyi healthcare wine and a making method thereof. The Folium Artemisiae Argyi healthcare wine comprises, by weight, 15-25 parts of Folium Artemisiae Argyi, 10-20 parts of Cortex Eucommiae, 3-8 parts of Semen Astragali Complanati, 5-10 parts of Indian Buead, 6-12 parts of Manyflower Solomonseal Rhizome, 3-8 parts of Radix Adenophorae, 8-15 parts of Radix Polygoni Multiflori, 6-15 parts of Echinacea Purpurea, 3-10 parts of Fructus Lycii and 2-8 parts of Radix Glycyrrhizae. By the Folium Artemisiae Argyi healthcare wine, load swimming time of mice can be prolonged significantly, generation of blood lactic acid is reduced, reserve of mice hepatic glycogen after exercise is increased, content of serum urea nitrogen of the mice after exercise can be lowered, and the Folium Artemisiae Argyi healthcare wine has the efficacy of relieving physical fatigue, and is high in stability, good in taste and worthy of large-scale popularization and application.

Systems, techniques and methods for estimating the metabolic state or flux, e.g., the body energy state (“BES”) of a patient, are disclosed. The BES provides a deep insight into the nutritional needs of the patient, thus allowing for a sort of exquisite glycemic control with regard to the patient. The invention discloses systems and methods for estimating fractional gluconeogenesis. The invention also discloses systems and methods for estimating and targeting patient blood lactate concentration, both as a target itself and as an intermediate step to estimating and targeting patient fractional gluconeogenesis glucose production. Nutritional support methods and formulations are also disclosed. The invention is suitable for any sort of patient, including those who are injured, such as with traumatic brain injury, ill, or have other conditions that stress the metabolic system.

The invention provides a method for diagnosing subacute rumen acidosis of dairy cows by using blood ALT, blood L lactic acid, milk fat and milk urea. The blood ALT, the blood L lactic acid, the milk fat and the milk urea are sensitive to subacute rumen acidosis of dairy cows, thus subacute rumen acidosis of dairy cows is diagnosed through detecting content of the blood ALT, the blood L lactic acid, the milk fat and the milk urea, and the content of the blood ALT, the blood L lactic acid, the milk fat is extremely and significantly correlated with the milk urea and the subacute rumen acidosis of dairy cows. The method is characterized by determining that: the sensitivity for diagnosing the dairy cows suffering from subacute rumen acidosis is 100.00% and the specificity is 57.14% when the blood ALT content is less than 16 U/L; the sensitivity for diagnosing the dairy cows suffering from subacute rumen acidosis is 75.00% and the specificity is 90.48% when the blood L lactic acid content is greater than 0.37 mmol/L; the sensitivity for diagnosing the dairy cows suffering from subacute rumen acidosis is 50.00% and the specificity is 100.00% when the milk fat content is less than 3.41%;and the sensitivity for diagnosing the dairy cows suffering from subacute rumen acidosis is 84.62% and the specificity is 90.48% when the milk urea content is less than 0.02%.