18 results about "Hepatic glycogen" patented technology

The invention discloses combined probiotics for improving sarcopenia as well as a preparation method and application of the combined probiotics, and belongs to the field of probiotics. The invention relates to a combined probiotic for improving sarcopenia. The combined probiotic comprises a lactobacillus reuteri body, a lactobacillus johnsonii body, a lactobacillus fermentum body and a bifidobacterium adolescentis body. The combined probiotics disclosed by the invention can be used for remarkably improving the overall symptoms of sarcopenia model mice, including inhibiting weight loss, constipation symptoms and colonic mucosa destruction, prolonging load swimming time, improving muscle endurance, improving skeletal muscle atrophy, improving the expression of I-type slow muscle fiber protein MyHC I and promoting slow muscle fiber repair, and has the effects of preventing and treating sarcopenia. The invention discloses a probiotic intervention method for treating sarcopenia, which comprises the following steps of: preparing probiotics for treating sarcopenia, reducing the content of inflammatory cytokines in muscular tissues, increasing the content of hepatic glycogen, improving systematic metabolism of mice with sarcopenia and damaged serum markers, including lactic acid, lactic dehydrogenase, creatine kinase, creatinine, alanine transaminase ALT and aspartate transaminase AST, providing a new scheme for probiotic intervention for sarcopenia, and being used for preparing related functional products or intervention means.

The invention discloses a preparation method of a fructus cannabis protein peptide product with effects of resisting fatigue and improving exercise ability, which comprises the following steps: performing preliminary crushing, ultralow-temperature freezing micro-crushing and low-temperature continuous phase-change extraction degreasing on fructus cannabis, performing step-by-step hydrolysis by using polysaccharase and 2.4 L bacterial protease to extract fructus cannabis protein, performing low-temperature salting-out, and performing freeze-drying to obtain the fructus cannabis protein peptide product with the effects of resisting fatigue and improving exercise ability. The fructus cannabis protein peptide powder is prepared through low-temperature ultrasonic dissolution promotion, high-pressure micro-jet homogenization, compound enzyme C hydrolysis, 1% pepsase, high-temperature enzyme deactivation, chlorophyll removal through counter-current extraction, hydrogen peroxide decoloration, ultralow-temperature instantaneous concentration, low-temperature vacuum belt type drying and low-temperature ultrahigh-pressure sterilization. The fructus cannabis protein peptide prepared by the invention has the following remarkable effects: 1, the exercise ability is remarkably improved, the accumulation of lactic acid and urea nitrogen is reduced, the exhaustion time is prolonged, and the physical and mental fatigue is relieved; 2, the content of hepatic glycogen and muscle glycogen is obviously increased, the energy reserve of the body is increased, the explosive power and the reactivity are improved, and the athletic performance is improved; and 3, the antioxidant level of the body is improved, and fatigue and immune recovery after exercise are promoted.

This invention belongs to the field of biomedical technology and discloses the application of NP in the preparation of a glycemic regulator for aging type 2 diabetes. The NP is a nanoscale complex formed by hydrogen bonding of turtle egg peptide with a molecular weight less than 3 kDa and naringenin at a mass ratio of 100:1. The formulation promotes liver glycogen synthesis and repairs pancreatic tissue structure and pancreatic β-cell function by activating the hepatic IRS1 / PI3K / AKT / GSK-3β signaling pathway and upregulating GLUT2 protein expression. The NP provided by this invention can significantly reduce fasting blood glucose levels in aging type 2 diabetic mice, improve oral glucose tolerance, and reduce the area under the blood glucose curve. Simultaneously, by restoring insulin signal transduction, it significantly reduces the insulin resistance index and improves the insulin sensitivity index, with an improvement level approaching that of the classic hypoglycemic drug metformin.

The invention belongs to the technical field of food, and provides a functional mare milk beverage and a preparation method thereof. The functional milk beverage aims to screen multiple traditional Chinese medicinal materials from the perspective of homology of medicine and food, is suitable for compatibility, is screened out and has a relatively good anti-fatigue effect, and is prepared from the following raw materials: fresh horse milk, xylooligosaccharide, codonopsis pilosula, poria cocos, Chinese yam, red dates, Chinese wolfberry fruits and fermentation strains. Researches show that the mare milk beverage can effectively improve the storage of hepatic glycogen and muscle glycogen, can provide more energy substances for the body, reduces the levels of blood lactic acid and blood urea after exercises, improves the anti-fatigue ability of the body, delays the generation of fatigue and accelerates the elimination of fatigue, and has the market value of being developed into products for relieving physical fatigue.

The invention discloses application of thiamine in improving the sugar utilization rate and growth performance of sturgeons, and belongs to the field of aquaculture. It is proved for the first time that by enhancing a glycolytic pathway, inhibiting a gluconeogenesis pathway and promoting glycogen decomposition, the thiamine effectively improves the sugar metabolism capacity of sturgeons and reduces hepatic glycogen deposition and fat accumulation, so that the risk of metabolic disorder is reduced. Meanwhile, thiamine also promotes muscle fiber growth, so that the growth speed of the sturgeons and the feed utilization rate are remarkably increased. Therefore, the thiamine can be used as a feed additive for preparing the feed for improving the sugar utilization rate and the growth performance of the sturgeons. A safe and efficient nutrition regulation and control scheme is provided for sturgeon culture, the feed utilization rate and culture benefits are improved, meanwhile, ecological risks such as antibiotic abuse are avoided, and remarkable economic benefits and application prospects are achieved.

This invention discloses the application of Dendrobium huoshanense protocorms in anti-fatigue and kidney-tonifying and aphrodisiac effects. Combining Dendrobium huoshanense protocorms with Cistanche deserticola, American ginseng, Rubus idaeus, Cornus officinalis, and Lycium barbarum significantly enhances the anti-fatigue and kidney-tonifying and aphrodisiac effects of the formula. Compared with Cistanche deserticola alone, adding Dendrobium huoshanense protocorms significantly prolongs the exhaustive swimming time in mice, reduces serum urea nitrogen and lactic acid levels, increases liver glycogen content, and increases muscle glycogen content. Compared with Cistanche deserticola alone, adding Dendrobium huoshanense protocorms significantly increases serum superoxide dismutase activity, reduces serum malondialdehyde content, increases serum testosterone content, increases penile nitric oxide synthase activity, and increases penile nitric oxide and cyclic guanosine monophosphate content in penile tissue.

The invention provides a composition and a beverage for relieving physical fatigue as well as a preparation method and application of the composition and the beverage, and belongs to the technical field of health-care foods. The composition for relieving physical fatigue comprises the following components in parts by weight: 8-80 parts of lotus seeds, 4-40 parts of Chinese wolfberry fruits, 4-40 parts of cornus officinalis, 4-40 parts of Chinese yams, 4-40 parts of poria cocos and 4-40 parts of gordon euryale seeds. Water-soluble chitosan is added into the composition for clarification, erythritol, mogroside, citric acid, black tea powder, beta-cyclodextrin and mint powder are added for taste modification, and the beverage is prepared. According to the composition disclosed by the invention, the contents of urea nitrogen and blood lactic acid in serum of mice can be remarkably reduced through synergistic cooperation of all the components; the content of liver glycogen and muscle glycogen in the mouse body is increased; the weight-bearing swimming time of the mouse is obviously prolonged; the residence time of the mouse on the rotating rod fatigue instrument is obviously prolonged; the forelimb grip strength value of the mouse is obviously increased; therefore, the effect of relieving physical fatigue is achieved.

The invention belongs to the technical field of component extraction, and particularly relates to an actinidia arguta stem source volatile active component extract and application thereof. The actinidia arguta stem source volatile active ingredient extract is obtained by releasing volatile active ingredients in an actinidia arguta stem source by utilizing the salting-out effect of sodium chloride and then carrying out headspace solid-phase microextraction through a DVB / CAR / PDMS three-phase extraction head. The actinidia arguta stem source volatile active ingredient extract provided by the invention has obvious alpha-glucosidase inhibitory activity and insulin sensitization effect; in addition, through double mechanisms of promoting peripheral glucose consumption and increasing hepatic glycogen synthesis, insulin resistance can be synergistically improved, and the hypoglycemic effect is achieved.

The application discloses a composition with synergistic hypoglycemic effect and a preparation method and application thereof, and belongs to the field of biomedical technology. The composition is prepared from defatted soybean meal powder, pueraria powder, polygonatum sibiricum redoute powder, polygonatum odoratum (mill.) druce powder and oat bran powder as a composite substrate, inoculated with bacillus ATCC 6633 for aerobic fermentation, under the condition that the first stage fermentation liquor is not inactivated, glucose, pyridoxal phosphate and lactobacillus ATCC 367 are added, and micro-aerobic and low-oxygen fermentation is sequentially carried out, and the composition is prepared through solid-liquid separation, ultrafiltration, concentration and drying. The composition can inhibit alpha-glucosidase activity, promote glucose utilization, improve insulin resistance and increase liver glycogen content, and can be used for preparing products for treating type 2 diabetes and auxiliary regulation of blood sugar.

This invention provides an anti-vertigo and / or anti-fatigue composition, its formulation, and its application, relating to the field of functional formulation technology. The composition comprises the following components in weight percentages: 0.01%-0.5% turmeric extract, 1%-5% branched-chain amino acids, 0.5%-3% ginger extract, and 0.05%-0.5% oyster peptides. Animal experiments have demonstrated that the composition of this invention can significantly reduce the vertigo response index in rats with motion sickness, prolong weight-bearing swimming time, reduce blood lactate and serum urea nitrogen levels, and increase liver glycogen reserves. Compared with commercially available anti-motion sickness chemical drugs such as dimenhydrinate, this invention achieves anti-vertigo effects without causing a decrease in weight-bearing swimming time and has significant anti-fatigue effects. The composition of this invention is composed of natural raw materials, has high safety, and achieves a synergistic effect of anti-vertigo and anti-fatigue, and can be widely used in the preparation of drugs or health products for the prevention and / or treatment of motion sickness and the relief of physical fatigue.

The present application relates to the technical fields of food processing and functional active peptide development, and particularly relates to a small molecule active peptide of Agaricus bisporus and a preparation method and application thereof. Small molecule polypeptides are prepared by using alkaline protease and flavor protease directional complex enzymolysis on Agaricus bisporus dry powder, and the small molecule polypeptides are separated and purified by ultrafiltration and dextran gel G-15 column, and combined with liquid chromatography-mass spectrometry analysis to obtain small molecule weight Agaricus bisporus polypeptides with amino acid composition of PNPGHPP, SPDGHAPGGPP, FFPVHH and LPPPHDF. The obtained small molecule weight Agaricus bisporus polypeptides have dual effects of antioxidant and anti-fatigue, can effectively reduce serum urea nitrogen and lactic acid, liver malondialdehyde content, improve liver glycogen content and superoxide dismutase and glutathione peroxidase activity, and have wide application prospect in the fields of food and health care products.

The invention discloses application of medium-chain fatty acid in promoting fructose absorption and glycogen supplement. Expression of fructose transporter GLUT5 in intestinal cells is up-regulated through octanoic acid, absorption of fructose and supplement of hepatic glycogen are promoted, a scientific basis is provided for basic research of relieving or preventing gastrointestinal discomfort, malnutrition and rapid energy supplement caused by fructose absorption and product development, and the pharmaceutical composition has great application value.

The invention provides bacillus coagulans NSL1204 capable of improving exercise tolerance and application of the bacillus coagulans NSL1204, and belongs to the technical field of microorganisms. The classification name of the bacillus coagulans NSL1204 disclosed by the invention is bacillus coagulans, and the preservation number of the bacillus coagulans NSL1204 is CCTCC (China Center for Type Culture Collection) NO: M 2025206. The bacillus coagulans NSL1204 can improve the levels of hepatic glycogen and muscle glycogen and enhance continuous supply of energy in the exercise process so as to improve exercise tolerance, has the functions of maintaining the blood sugar level and reducing the content of blood lactic acid after exercise, can be used for preparing sports drinks or granules, and has a probiotic function; the bacillus coagulans strain NSL1204 can also be applied to preparation of food resistant to gastric acid, bile salt and heat; the bacillus coagulans NSL1204 is wide in application range and high in biological safety performance in the application of preparing food.

The invention discloses a preparation method of microbial fermentation American ginseng helpful for relieving exercise-induced fatigue, and the microbial fermentation American ginseng is prepared by taking American ginseng, probiotics and compound enzyme as main raw materials through crushing, digestion, enzymolysis, extraction, sterilization, fermentation and drying. The content of total saponins and rare ginsenosides Rg3 and Rg5 in the obtained fermented American ginseng powder is remarkably increased through treatment of a specific process, and mouse model experiments prove that the fermented American ginseng powder can practically, effectively and remarkably prolong the exhaustion time of mice, improve the content of hepatic glycogen and muscle glycogen and the activity of antioxidant enzymes (SOD and GSH-Px), and can be used for preparing the health-care food. Meanwhile, the levels of lactic acid, urea nitrogen and malondialdehyde in serum are reduced.

The application provides a traditional Chinese medicine composition and application thereof. Animal experiments show that the traditional Chinese medicine composition can prolong the exercise distance, obviously reduce the electric shock times, increase the superoxide dismutase content in the liver, the liver glycogen content and the muscle glycogen content, reduce the lactic acid generation, thereby slowing down the exercise fatigue. The traditional Chinese medicine composition can also prolong the normal pressure anoxia time, prolong the survival time, increase the panting times, reduce the brain oxygen consumption, has a good anti-stress effect, and can effectively treat the immunodepression and cancer fatigue.

The invention relates to the technical field of food processing, and discloses a compound probiotic solid beverage formula with an anti-fatigue function, and the compound probiotic solid beverage formula comprises the following raw materials: 1-5 parts of compound probiotics, 10-25 parts of prebiotics, 5-15 parts of an anti-fatigue active component, 40-70 parts of a filler, and 3-8 parts of a flavor regulator. The probiotic beverage disclosed by the invention is remarkable in anti-fatigue effect: the compound probiotics, the maca extract, the ginsenoside and other active ingredients have a synergistic effect, so that the liver glycogen reserve of an organism can be remarkably improved, the content of blood lactic acid after exercise is reduced, the endurance time is prolonged, and the fatigue feeling is relieved; the probiotics are stable in activity, all the raw materials meet food-grade standards, no artificially synthesized additive is added, no side effect is caused after long-term eating, and the product is suitable for various people; the solid beverage can be drunk after being brewed, is convenient to carry and store, and is suitable for daily supplement.

The invention belongs to the technical field of traditional Chinese medicine, and particularly relates to a preparation method and application of a rhizoma gastrodiae yin-tonifying oral preparation. The oral preparation is prepared from the following raw materials in parts by weight: 20 to 25 parts of rhizoma gastrodiae, 15 to 20 parts of radix rehmanniae, 14 to 17 parts of fructus corni, 17 to 21 parts of fructus lycii, 15 to 20 parts of hail, 10 to 15 parts of silver grass, 10 to 20 parts of radix ophiopogonis, 10 to 14 parts of radix polygonati officinalis, 5 to 10 parts of radix ginseng, 7 to 12 parts of rhizoma atractylodis macrocephalae, 5 to 10 parts of poria cocos, 10 to 15 parts of semen ziziphi spinosae, 5 to 10 parts of fructus schisandrae chinensis, 5 to 8 parts of radix angelicae, 1 to 5 parts of radix angelicae sinensis and 3 to 8 parts of liquorice root. Animal experiments prove that the oral preparation can prolong the exhaustive swimming time of mice, reduce the content of blood lactic acid and serum urea of the mice after swimming and increase the reserve of hepatic glycogen, and has a remarkable anti-fatigue effect.

This invention discloses a traditional Chinese medicine composition for improving blood sugar, its preparation method, and its application, belonging to the field of traditional Chinese medicine compound technology. The composition is prepared by combining scorpion, centipede, jujube seed, dandelion, cardamom, and platycodon in specific weight proportions. Based on the pathological mechanism of integrated traditional Chinese and Western medicine, this invention establishes liver phlegm obstruction, abnormal liver qi rising, and liver stagnation with internal heat disturbing the hypothalamus as the core pathogenesis of type 2 diabetes. Phlegm and dampness stagnation in the liver collaterals leads to impaired liver glycogen synthesis, and compensatory hyperactivity of the hypothalamus causes elevated blood sugar, polyphagia, and polydipsia. Deficiency of peripheral fluids and blood induces muscle atrophy and prediabetic foot lesions. This invention abandons the drawbacks of traditional yin-nourishing drugs that are greasy and promote dampness, using insect-derived drugs to clear phlegm and dampness from the liver collaterals, combined with herbs that clear the liver, nourish the liver, strengthen the spleen, and promote lung function. It regulates glucose metabolism at multiple targets, calms hypothalamic central hyperactivity, and nourishes the extremities. This formula can be prepared at home. It has a mild medicinal effect, stabilizes blood sugar, improves dry mouth and excessive appetite, numbness and atrophy of limbs, and slows the progression of diabetic foot. It has clinical application and industrial transformation value.