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97 results about "Hepatic glycogen" patented technology
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Special diet for hyperglycemia patients
ActiveCN103404757AStable healthEffect on reducing the development of coronary heart disease-related conditionsFood preparationAcute hyperglycaemiaChinese traditional
The invention belongs to the technical field of medicine-food homologous formula food and particularly relates to special diet for hyperglycemia patients. The reason inducing hyperglycemia is that hepatic glycogen output is increased, too much high-fat food is ingested, the pancreatic islet function can not excellently secrete insulin, and then, the blood sugar content is increased. The traditional Chinese medical science always stresses that dietotherapy is better than medication, so as to avoid injection and medication and even pain of surgery. According to the special diet, whole grains are perfectly combined with medicine-food homologous and new-resource-food traditional Chinese medicines, and diet and health preserving are organically combined so as to regulate, prevent and resist hyperglycemia; probiotics are creatively utilized as a pioneer based on the inheritance of Chinese traditional Chinese medicine treasure treatment methods, and the proliferation of the probiotics is promoted, so that the movement functions of the spleen and stomach are enhanced; and meanwhile, various natural and original ecological medicine-food homologous edible materials are added according to the physical characteristics of hyperglycemia patients, so that the special diet has the unique advantage of integrated dietotherapy, prevention and regulation effects.
Owner:杭州劲膳美健康管理有限公司
Separation and purification method of human umbilical cord mesenchymal stem cell exosome and application of human umbilical cord mesenchymal stem cell exosome
ActiveCN108103017AHigh protein purityGood repeatabilityMetabolism disorderSkeletal/connective tissue cellsSucrosePurification methods
The invention provides a separation and purification method of a human umbilical cord mesenchymal stem cell exosome and an application of the human umbilical cord mesenchymal stem cell exosome, and belongs to the technical field of medicines. The human umbilical cord mesenchymal stem cell exosome provided by the invention is prepared by cultivating human umbilical cord mesenchymal stem cells via aserum-free medium, collecting supernatant liquid, implementing centrifuging as well as ultra-filtration and concentration, transferring a concentrated solution onto a 30% sucrose-heavy water densitypad and implementing further purification through sucrose density centrifuging, so that the human umbilical cord mesenchymal stem cell exosome is obtained. According to the separation and purificationmethod that the human umbilical cord mesenchymal stem cell exosome is obtained through separation and purification, immunoreactivity is effectively reduced, and a controllable dosage when the human umbilical cord mesenchymal stem cell exosome is used is guaranteed. The human umbilical cord mesenchymal stem cell exosome, by improving a degree of activating an insulin signaling pathway of a type IIdiabetes animal model, can inhibit composition and decomposition of hepatic glycogen, so that glucose metabolism homeostasis can be achieved; and meanwhile, the sensitivity of the type II diabetes animal model to insulin and an insulin secretion function of pancreatic [beta] cells can be improved and a blood glucose concentration can be reduced, so that the application of the human umbilical cordmesenchymal stem cell exosome to the preparation of medicines for treating type II diabetes can be achieved.
Owner:JIANGSU UNIV
Health-care vinegar, brewing method and hyperglycemic reduction application thereof
ActiveCN101775349AAdd flavorHigh in nutrientsMetabolism disorderMicroorganism based processesAmyrisRhizopus
The invention discloses health-care vinegar, a brewing method and hyperglycemic reduction application thereof. The health-care vinegar is prepared from 4 to 7 parts of rice, and 2 to 4 parts of yam. The brewing method comprises the following steps: (1) pulping the rice and yam with water, regulating the starch concentration to be over 10 percent by adopting sterile water or traditional Chinese medicinal extract, and heating the mixture for 5 to 10 minutes at the temperature of between 125 and 130 DEG C; (2) adding rhizopus, activated dried yeast, aroma-producing yeast and lactic acid bacteria into the sterilized mixture to ferment distilled wort, adding lactic acid bacteria seed fermentation broth into the mixture when the alcohol content is detected to be between 6 and 8 percent, leading the fermentation temperature to be between 26 and 34 DEG C, adding edible salt into the mixture when the acidity of the fermentation broth is not changed, and stopping alcoholic fermentation; and (3) ageing the fermented acid solution for over 15 days at the temperature of between 12 and 20 DEG C, and filtering the solution to obtain the health-care vinegar. The brewed health-care vinegar can reduce blood sugar of experimental II type diabetic rats, shows certain dose-response relationship, can improve the insulin sensitivity of the experimental II type diabetic rats, can improve the carbohydrate tolerance of the experimental II type diabetic rats, and improve the content of hepatic glycogen and muscle glycogen.
Owner:SUN YAT SEN UNIV
Madder extract and preparation method and application thereof
The invention relates to madder extract and a preparation method and an application thereof, wherein the madder extract is prepared from the following steps: pulverizing the rhizome of the madder, and using ethanol for percolation extraction at room temperature; recovering the ethanol and obtaining extract; dissolving the extract into water, and heating and completely dissolving the extract; and then, extracting the extract by using ethyl acetate, and concentrating the extract to obtain the madder ethyl acetate extract. The experiment indicates that the madder ethyl acetate extract and the compound alizarin can effectively reduce the blood glucose value, the GSP value, the TG value and the content of MDA in the tissue homogenate of the mouse with hyperglycemia caused by alloxan, and can obviously increase the SOD activity value of the hepatocyte of the mouse and increase the content of the hepatic glycogen of the tissue. The results prove that the madder ethyl acetate extract and the alizarin have good effect on reducing the content of the blood glucose.
Owner:HENAN UNIVERSITY
Anti-fatigue Maca extract and functional drink including same
InactiveCN105558528AEnhance reserve functionThe taste is sweet and sour and cool and refreshingFood preparationDecompositionAmino acid metabolism
The invention relates to an anti-fatigue Maca extract and a functional drink including the same. The anti-fatigue Maca extract is prepared from the following raw materials by mass: 0.8 to 1.2 of Maca powder, 0.1 to 0.3 of rhodiola root powder, 0.2 to 0.5 of yacon powder, 0.2 to 0.5 of crab apple powder and 0.08 to 0.12 of mint leaf powder. According to the invention, the Maca, rhodiola root and yacon are blended, so comprehensive anti-fatigue effect is exerted; the crab apple and mint leaf enable the beverage to has sour-sweet, cool and refreshing taste; through microwave treatment of Maca powder, the irritant and pungent taste of Maca beverages can be eliminated; and anti-fatigue accessory factors are added for coordinate regulation of amino acid metabolism, carbohydrate decomposition and lipid metabolism of the body, so body fatigue caused by acute exercises of the human body is regulated, the function of reservation of hepatic glycogen is improved, etc.
Owner:HUAZHONG UNIV OF SCI & TECH +1
Anti-fatigue anti-aging compound capsules containing sea cucumber peptides and oyster peptides, and preparation method of capsules
The invention relates to anti-fatigue anti-aging compound capsules containing sea cucumber peptides and oyster peptides. The components in each 500mg of capsule contents are as follows: 200-300mg of sea cucumber peptides, 100-200mg of oyster peptides, 50-100mg of maca extractive, 50-100mg of polygonatum sibiricum rhizome extractive, and 5-10mg of astaxanthin. A preparation method comprises weighing raw materials according to proportioning, conducting uniform mixing, conducting sieving with a 100-mesh sieve to obtain mixed powder, and then filling capsule shells with the obtained compound powder by adopting a conventional capsule filling process so as to obtain the compound capsules. The compound capsules prepared by the invention can prolong the weight-bearing swimming time of mice, reducethe blood lactic acid level of the mice after exercise, and increase hepatic glycogen reserve of the mice; and the compound capsules have obvious protection effect on the damage caused by oxidation in the mice of a rapid aging model. Through human test-meal trials, the compound capsules can obviously relieve fatigue symptoms including fatigue, hypodynamia, soreness of waists and legs, and sexualhypofunction. The trials indicate that the compound capsules have good anti-fatigue and anti-aging effects, and have no side effect on human bodies, and can be taken for a long term.
Owner:陈石良
Fatigue-relieving traditional Chinese medicine health product and preparation method thereof
ActiveCN104825791ADefinite curative effectNo side effectsAntinoxious agentsUnknown materialsEpimediumLycium barbarum fruit
The invention discloses a fatigue-relieving traditional Chinese medicine health product, which is composed of the following seven traditional Chinese herbals: ginseng, processed rhizoma polygonati, wolfberry, raspberry, maca, epimedium, and cervus elaphus antler. The pharmacodynamic test result show that the health product can prolong the load swinging time of mice, the contents of hepatic glycogen and lactic dehydrogenase are increased, the contents of serum urea nitrogen and blood lactic acid are reduced, and the health product has a prominent fatigue relieving effect.
Owner:HUBEI GOLDEN EAGLE BIOTECH
Mollugin and preparation method and application thereof
InactiveCN102875517AGood hypoglycemicGood treatment effectOrganic active ingredientsOrganic chemistryMass ratioSilica gel
The invention discloses a preparation method of mollugin. The preparation method includes: taking India madder root, and using 5-15 times of petroleum ether to perform heating reflux extraction for 20-40min; recycling petroleum ether, and vacuum drying to remove petroleum ether so as to obtain extract; and subjecting the extract to 200-300-mesh silica gel column chromatography, eluting with petroleum ether, performing TLC (thin layer chromatography) detection, combining components rich in mollugin, subjecting to Sephadex LH-20 gel column chromatography, eluting with mixture of chloroform, petroleum ether, and methanol in mass ratio of 5:5:1, subjecting to silica gel H-column decompression column chromatography, eluting with petroleum ether, and recrystalizing with hot ethanol to obtain the mollugin. The invention further discloses application of the mollugin in preparation of hypoglycemic drugs and preparation of drugs for treating diabetes. Experiments show that the mollugin can effectively reduce blood sugar, TC (total cholesterol), TG (total glycerin) and MDA (methylene dioxyamphetamine) content of mice with high blood sugar caused by alloxan, and can evidently increase SOD (superoxide dismutase) activity and hepatic glycogen content of the mice.
Owner:HENAN UNIVERSITY
Lactobacillus paracasei and application thereof
ActiveCN111560331AHigh inhibition rateIncrease weightAntibacterial agentsNervous disorderBlood sugarSpleen
The invention belongs to the technical field of microorganisms, and particularly relates to lactobacillus paracasei with the effects of reducing blood sugar, protecting the oral cavity and resisting depression and application of the lactobacillus paracasei. The lactobacillus paracasei nbk-LC16 provided by the invention has relatively strong acid resistance and cholate resistance, is good in tolerance in artificial gastric juice and artificial intestinal juice, and can effectively reduce blood sugar and inhibit streptococcus mutans. The influence of the lactobacillus paracasei nbk-LC16 on hyperglycemia mice is studied, and after the lactobacillus paracasei nbk-LC16 is perfused, compared with model group mice, the weight of the hyperglycemia mice is remarkably increased in 8W, the liver index and the spleen index are remarkably reduced, FBG and PBG are remarkably reduced, the HbA1c and insulin levels are remarkably reduced, and the hepatoglycogen content is increased. Test results show that the lactobacillus paracasei nbk-LC16 can regulate blood glucose by regulating insulin level and HbA1c and promoting conversion of blood glucose into hepatic glycogen. Researches on the inhibitioneffect of the streptococcus mutans strain on streptococcus mutans show that the streptococcus mutans strain can be effectively inhibited through in-vitro tests and oral test results, and the oral cavity and tooth health can be protected; meanwhile, the anti-depression effect is achieved.
Owner:诺佰克(武汉)生物科技有限公司
Preparation method for deer blood peptide and anti-fatigue effect of deer blood peptide
InactiveCN107164446AWorks well togetherHydrolysed protein ingredientsAntinoxious agentsFiltrationHydrolysis
The invention relates to a preparation method of deer blood peptide and its anti-fatigue effect, belonging to the field of medicine. Drying of deer blood: use a spray dryer, adjust the inlet temperature to 180°C, the outlet temperature to 80°C, and the speed to 26,000-30,000 rpm; deer blood protein hydrolysis: the concentration of deer blood protein is 3%, and alkaline protease is used for hydrolysis , The hydrolysis conditions are: temperature 53°C, time 5.5h, pH 9.5, enzyme amount 1272u / g; purification of deer blood peptide: membrane filtration and gel chromatography. In the present invention, the anti-fatigue experiment of mice is used to study the activity of the deer blood peptide. Animal experiments show that the polypeptide produced by the optimal hydrolysis process can significantly prolong the swimming time and low-pressure hypoxia tolerance of mice, the content of liver glycogen is significantly higher than that of the control group, and the content of blood lactic acid is significantly lower than that of the control group; It has good anti-fatigue effect.
Owner:吉林省金鹿药业有限公司
Compound dendrobium candidum blood-glucose-reducing capsule
InactiveCN104324244ASource of reductionIncrease the wayMetabolism disorderCapsule deliverySide effectDiabetic complication
The invention discloses a compound dendrobium candidum blood-glucose-reducing capsule. The capsule is prepared from the dendrobium candidum with other seven traditional Chinese medicines, including astragalus, kudzu roots, dried radix rehmanniae, root of Chinese trichosanthes, polygonatum kingianum, fructus lycii and red peony roots, and is prepared through following steps: crushing, extraction, mixing, granulation and packaging. The components influent on each other and work synergistically. The capsule can promote pancreatic [beta] cells to secrete insulin and inhibit pancreatic [alpha] cells to secrete glucagon, and meanwhile can inhibit decomposition of hepatic glycogen due to epinephrine and promote synthesis of the hepatic glycogen, thereby reducing sources of blood glucose, increasing outlet of the blood glucose and reducing a blood glucose value. The capsule is free of toxic and side effect and untoward reactions, and can effectively control and eliminate symptoms, including polyphagia, polydipsia, polyuria and emaciation, in diabetes and diabetic complications.
Owner:刘方旭
Traditional Chinese medicine with anti-fatigue function and preparation method thereof
InactiveCN104013802AVitalityDynamicAntinoxious agentsUnknown materialsUrea levelTraditional medicine
The invention discloses a traditional Chinese medicine with an anti-fatigue function and a preparation method thereof. The traditional Chinese medicine is prepared from seven traditional Chinese medicinal materials such as rhizoma polygonati, astragalus, American ginseng, medlar, mulberry, donkey-hide gelatin, walnut kernel. The pharmacodynamic test proves that the loaded-swimming time of a mouse can be prolonged, the hepatic glycogen content is increased, the blood urea level is reduced, and the traditional Chinese medicine has an obvious anti-fatigue effect. The safety test proves that the traditional Chinese medicine is high in safety, and the formula is scientific and is suitable for long-term administration.
Owner:HUBEI GOLDEN EAGLE BIOTECH
Blood sugar reducing tea rice porridge containing rehmannia root and preparation method thereof
InactiveCN103250969APromote protosynthesisLower blood sugarFood preparationPumpkin seedAdditive ingredient
The invention discloses blood sugar reducing tea rice porridge containing rehmannia root and a preparation method thereof. The tea rice porridge is prepared from 50-60 of glutinous rice, 15-20 of rhubarb root and rhizome rice, 13-18 of green tea, 7-10 of red sorghum, 3-6 of gordon euryale seed, 3-5 of small red beans, 3-5 of rehmannia root, 2-4 of pumpkin leaves, 0.8-1.5 of mulberry leaves, 0.8-1.2 of coptis root, 1-1.5 of pineapple, 0.8-1.5 of apple, 1.2-1.5 of Chinese dwarf cherry leaves, 1.2-1.5 of grosvenor momordica fruit leaves and a defined amount of white granulated sugar. The rice porridge produced by the preparation method has the advantages that the rice porridge has the special fragrance of tea and is tasty; the effective part (R-BP-F) of the added rehmannia root has a good effect on reducing the blood sugar; alkaloid fagomine and polysaccharides contained in the mulberry leaves promote beta cells to secrete insulin; and the insulin can promote utilization of sugar by cells and hepatic glycogen synthesis and improve glycometabolism so as to finally achieve the effect on reducing the blood sugar; and the product also contains various traditional Chinese medicine ingredients beneficial to human bodies and is beneficial to body health after being eaten for a long time.
Owner:SHITAI HUINONG AGRI ECONOMIC COOPERATION
Pyrazole compounds and antidiabetes agents containing the same
InactiveCN101208306AHigh activityNo side effectsOrganic chemistryHeterocyclic compound active ingredientsAzideDiabetes mellitus
A pyrazole compound represented by the general formula (I) or a salt thereof which has a hepatic glycogen phosphorylase inhibitory activity and therefore is useful as a therapeutic or prophylactic agent for diabetes or a pharmacologically salt thereof : wherein the ring Q represents an aryl group or an aromatic heterocyclic group; R<1> represents a hydrogen atom, a halogen atom, a C1-6 alkyl group or a C1-6 alkoxy group; R<2> represents a halogen atom, a C1-6 alkyl group, a C1-6 alkoxy group or an azide group; R<3> represents a halogen atom, a hydroxyl group, a C1-6 alkyl group, a halo-C1-6 alkyl group, a C1-6 alkoxy group, an azide group, an amino group, an acylamino group or a C1-6 alkylsulfonylamino group; R<4> and R<5> independently represent a hydrogen atom, a C1-6 alkyl group which may be substituted, a a C3-8 cycloalkyl group, a saturated heterocyclic group which may be substituted, an aryl group which may be substituted, a C7-14 aralkyl group, an aromatic heterocyclic group or the like.
Owner:JAPAN TOBACCO INC
Fatigue preventing health-care composition and a preparation method thereof
InactiveCN106509887AComprehensive conditioning functionImprove fatigue resistanceFood ingredient functionsFreeze-dryingTaurine
Owner:陈石良
Extract of active anti-fatigue part of okra, and preparation method and application thereof
The invention discloses an extract of an active anti-fatigue part of okra, and a preparation method and application thereof. The extract of the active anti-fatigue part of okra uses total polyphenols as a main active anti-fatigue component, wherein the total polyphenols account for 11.79 to 23.34% of the total mass of the extract of active anti-fatigue part and mainly comprise catechin derivatives and quercetin derivatives, and the quercetin derivatives are mainly composed of quercetin-3-O-gentiobioside, quercetin-3-O-glucose-xyloside, isoquercitrin, quercetin-3-O-malonyl-glucoside, rutin and quercetin. The extract of the active anti-fatigue part of okra provided by the invention can substantially prolong the load swimming time of mice, eliminate lactic acid accumulation after sports, reduce the content of serum urea nitrogen, increase hepatic glycogen and improve the antioxidation capability of mice in a stress state, and has substantial anti-fatigue effect.
Owner:INST OF MEDICINAL PLANT DEV CHINESE ACADEMY OF MEDICAL SCI
Fatigue preventing health-care food composition and health-care food preparation
The present invention belongs to the field of health-care food and particularly relates to a fatigue preventing health-care food composition and a health-care food preparation. Oligopeptides originated from wheat proteins, soybean proteins and animal collagen are combined, then apricot kernel powder, red date powder, oatmeal and cheese powder ingredients are added for the fatigue preventing health-care food, and the health-care food composition can effectively improve the changes of metabolites of hepatic glycogen content, serum urea nitrogen content, blood lactate acid content, etc. under body fatigue state and effectively improve the body health status.
Owner:YANTAI NEW ERA HEALTH IND
Sustained release preparation of glipizide/metformin hydrochloride and its preparation method
InactiveCN1602873APromote secretionImprove utilizationOrganic active ingredientsMetabolism disorderIrritationMetformin Hydrochloride
The invention relates to a compound sustained-release preparation composed of glipizide and metformin hydrochloride, and its preparing method. The weight ratio of glipizide to metformin hydrochloride is 1 : 100-200, the best ratio is 1:100 and it adds a proper amount of medicinal auxiliary to the preparation. The compound sustained-release tablet can not only make advantages complementation on glipizide and metformin hydrochloride, promote and increase secretion of beta-cell insulin, and raise the utilization of glucose in tissues, such as muscle, etc, but also reduce the stimulus of metformin hydrochloride to stomach intestine, and largely strengthen curative effect and drug application safety.
Owner:海南国栋药物研究所有限公司
Needle mushroom extract and preparation method and application thereof
InactiveCN105920051AInhibition of activityLower blood sugarMetabolism disorderFungi medical ingredientsPancreatic hormoneFatty acid
The invention relates to the field of active substances, in particular to a needle mushroom extract and a preparation method and application thereof. The needle mushroom extract prepared through the method provided by the invention mainly comprises polysaccharide, protein, vitamins and mineral substances. In vitro experiments show that the needle mushroom extract provided by the invention can inhibit the activity of in vivo alpha-glycosidase. In vivo experiments show that the needle mushroom extract can obviously reduce the blood glucose of II-type diabetic rats, is used for adjusting lipid metabolism disorder, improving insulin resistance, reducing serum free fatty acid level, increasing hepatic glycogen and muscle glycogen storage and repairing damaged pancreas, and has an obvious effect of treating II-type diabetes.
Owner:JILIN INST OF CHEM TECH
Composition having functions of relieving fatigue and tonifying yang
The invention discloses a lycium barbarum polysaccharide-deer blood composition having functions of relieving fatigue and tonifying yang. Lycium barbarum polysaccharide and a deer blood dry powder asactive components are made into an oral preparation in accordance with conventional excipients and processes of the pharmaceutics, or are made into a food prepared for a meal in accordance with a health-care food process. Experiments show that the composition can significantly prolong the loaded swimming time of small mice, reduce the content of blood lactic acid and serum urea nitrogen after thesmall mice do exercise and increase the reserve amount of hepatic glycogen; compared with the fatigue relieving function of the single use of lycium barbarum polysaccharide and deer blood, the function is more comprehensive, and the effect is more effective. The composition also can significantly enhance the gonadal hormone level of rats and the activity of superoxide dismutase in testis tissues,reduces the content of malondialdehyde, enhances the antioxidant capacity of the rat, and has stronger activity than the activity of lycium barbarum polysaccharide and deer blood groups. Therefore, the composition can be used for enhancing the anti-fatigue and yang-tonifying ability of sub-health young and middle-aged men, as well as conditioning middle-aged and elderly patients with physical deficiency.
Owner:LANZHOU INST OF CHEM PHYSICS CHINESE ACAD OF SCI
Application of anoectochilus roxburghii polysaccharide extract
ActiveCN107412254AProlong weight-bearing swimming timeLower serum urea nitrogen levelsOrganic active ingredientsAntinoxious agentsNitrogenAnoectochilus roxburghii
The invention relates to the field of medicines, in particular to application of an anoectochilus roxburghii polysaccharide extract. The anoectochilus roxburghii polysaccharide extract is used for preparing an anti-fatigue medicine, the anoectochilus roxburghii polysaccharide extract has obvious anti-fatigue effect and can obviously prolong weight-loading swimming time of a mouse, lower serum lactate dehydrogenase level after swimming, lower serum urea nitrogen content, improve the oxidation resistance of the mouse in a stress state and increase content of hepatic glycogen and muscle glycogen.
Owner:FUJIAN UNIV OF TRADITIONAL CHINESE MEDICINE
Application of reduced coenzyme II
The invention relates to the biotechnology field and in particular relates to application of a reduced coenzyme II. Test results show that NADPH can be used for obviously prolonging weight-bearing swimming time of a mouse, increasing reserve of hepatic glycogen of a fatigued mouse and reducing lactic acid and urea nitrogen content of the fatigue mouse, so that the reduced coenzyme II has an obvious anti-fatigue effect.
Owner:SUZHOU RENBEN PHARMA
Application of long non-coding RNA uc.48+ small interfering RNA to preparation of medicine for treating DM and complications
ActiveCN105126118AHigh expressionHigh activityOrganic active ingredientsMetabolism disorderDiseaseWhole body
The invention relates to application of long non-coding RNA (Ribonucleic Acid) uc.48+ small interfering RNA to preparation of medicine for treating DM (Diabetes Mellitus) and complications. In experiments, the conditions that the long non-coding RNA uc.48+ small interfering RNA can lower the raised blood sugar of a rat of a type 2 DM model and can improve the hepatic glycogen level are observed; and the GK (glucokinase) activity improvement is involved in the mechanism aspect. The long non-coding RNA uc.48+ small interfering RNA can also be applied to the preparation of medicine for treating GK function abnormity mediated diseases. The long non-coding RNA uc.48+ small interfering RNA can be used for preventing and treating the diseases as medicine in medicine preparations such as oral administration preparations, injection preparations, tablet preparations or other local or whole body available preparations.
Owner:NANCHANG UNIV
Extract product capable of preventing oxidation, delaying aging, and nourishing heart and cerebral vessels, and preparation method thereof
InactiveCN108991516APromote absorptionHigh biological potencyYeast food ingredientsNatural extract food ingredientsFermentationGrape extract
The invention relates to an extract product capable of preventing oxidation, delaying aging, and nourishing heart and cerebral vessels, and a preparation method thereof. According to the preparation method, a grape extract and a mixed fruit powder are prepared firstly, and are mixed with yeast for fermentation, after metabolism of yeast, organic conversion of resveratrol in the grape extract, andanthocyanidin and a plurality of trace elements in the mixed fruit powder is realized, so that adsorption on nutrients is improved, and the biological value is increased. It is confirmed by animal experiments that the extract product is capable of prolonging mouse life time and rat loaded swimming time obviously, reducing blood urea nitrogen content, reducing blood lactic acid accumulation, and increasing hepatic glycogen content, possesses obvious anti-fatigue activity, is capable of increasing the activity of superoxide dismutase in rat serum, and accelerating malonaldehyde removing rate, and possesses obvious anti-oxidation activity. The extract product is prepared from pure natural materials, no chemical raw material is added, no toxic or side effect is caused by long term eating. Theextract product is suitable for fatigable people, people high in cholesterol content, and people with long term smoking and drinking habits.
Owner:CHANGCHUN HEALTH FUTURE MEDICINE TECH CO LTD
Hatching method for increasing energy reserve of commercial generation hatching eggs of white feather broilers
ActiveCN105432565ADoes not reduce hatchabilityImprove hatchabilityAnimal husbandryChest musclesBroiler
The invention discloses a hatching method for increasing energy reserve of commercial generation hatching eggs of white feather broilers. In a later hatching stage of the commercial generation hatching eggs of the white feather broilers, 0.4 mL of sterilizing injection nutritive liquid is injected to embryo eggs, then hatching continues to be carried out under original hatching conditions for 21 days, and then the broilers are hatched, wherein each mL of the sterilizing injection nutritive liquid is prepared from 60-62.5 mg glucose and 10-15 mg creatine monohydrate. Compared with traditional hatching, by means of the technology, the energy matter reserve mainly including hepatic glycogen in the liver and the energy matter reserve mainly including creatine and phosphocreatine in the chest muscle in the later broiler embryo hatching stage are significantly increased and can last to the time when the broilers are one day old, the growing speed of the broilers in the early hatching-out period can be increased, and the breeding production efficiency of the broilers can be improved. The hatching method has the advantages of being low in cost, easy and convenient to implement, practical, high in operability and the like, and is suitable for being applied to poultry hatching production.
Owner:NANJING AGRICULTURAL UNIVERSITY
Application of clam meat oligosaccharide in preparation of hypoglycemic drugs and preparation method of clam meat oligosaccharide
ActiveCN104784192AGood hypoglycemicNo side effectsOrganic active ingredientsSugar derivativesAcute toxicity testingSide effect
The invention relates to application of a clam meat oligosaccharide in preparation of drugs or health foods for decreasing blood sugar and preventing and treating diabetes and a preparation method of the clam meat oligosaccharide. The optimized molecular weight range of the clam meat oligosaccharide is a 500-2000 clam meat oligosaccharide compound, and the total content is higher than 50 percent. Experimental results show that the clam meat oligosaccharide can significantly inhibit the blood sugar level and improve the glucose tolerance of model mice with alloxan-induced diabetes; the clam meat oligosaccharide has a significant effect of decreasing the blood sugar for mice with II type diabetes induced by high fat diet and STZ and the main expressions are as follows: the abnormal glucose tolerance of the mice with the II type diabetes is improved, the rise of plasma HbA1c is inhibited, the contents of hepatic glycogen and muscle glycogen are significantly increased, the utilization of hepatic glycogen is enhanced, the generation of glycogen is inhibited, the glucagon secretion is inhibited, the reserve of glycogen is enhanced, and the heteroplasia of sugar is reduced. Acute toxicity tests and researches show that the clam meat oligosaccharide has no toxic or side effects and is high in safety.
Owner:SUN YAT SEN UNIV
Application of sika deer spleen extract in anti-fatigue medicaments
ActiveCN104324357AImprove the ability to withstand hypoxia at atmospheric pressureIncreased resistance to sodium nitrite toxicityHydrolysed protein ingredientsAntinoxious agentsBiotechnologySpotted deer
The invention relates to application of a sika deer spleen extract in anti-fatigue medicaments. Animal experiments prove that the sika deer spleen extract prepared by a process disclosed by the invention can improve the hypoxia tolerance of mice at normal pressure, improve the resistance to sodium nitrite toxicity of the mice, prolong the swimming time of the mice, reduce the content of urea nitrogen in serum of the mice after strenuous exercises, reduce the physiological load of the mice after motion, increase the glycogen reserve of the mice and realize a significant anti-fatigue effect, and can be used for preparing the medicaments and health foods with the anti-fatigue effect.
Owner:北京中京丰创科技有限公司
Liquiritigenin-cyclodextrin or cyclodextrin derivative clathrate, composition containing clathrate, and preparation method and novel application of clathrate
The invention relates to a liquiritigenin-cyclodextrin or cyclodextrin derivative clathrate, a composition containing the clathrate, and a preparation method and novel application of the clathrate; the application of the liquiritigenin-cyclodextrin or cyclodextrin derivative clathrate in the preparation of drugs for improving or treating exercise-induced fatigue, and the pharmaceutical composition are prepared by the inventor during the study on the liquiritigenin-cyclodextrin or cyclodextrin derivative clathrate by: establishing an animal model, and detecting change levels of hepatic glycogen, blood lactic acid and urea nitrogen in a mouse sample; it is verified that liquiritigenin can resist exercise-induced fatigue, and the pharmaceutical composition for resisting exercise-induced fatigue is prepared.
Owner:宁夏蓝博思化学技术有限公司
Processing production technology for polygonum multiflorum
The invention discloses a processing production technology for polygonum multiflorum. Conventional processing technologies for polygonum multiflorum are long in processing period and waste manpower and material resources. The processing production technology for polygonum multiflorum comprises: selecting polygonum multiflorum dry sheets immersed by black soybean juice, putting a bamboo or wood container loaded with polygonum multiflorum dry sheets in a circulated steam kettle for high-temperature boiling for 12 h. The content of the component stilbenes with liver-protecting effect is relatively high after 12 h boiling; and combined anthraquinones contained in raw polygonum multiflorum sheets has purgation effect and light hepatotoxicity, and is converted into free anthraquinones which has no purgation effect after polygonum multiflorum is processed. Therefore, processed polygonum multiflorum is reduced in toxicity and helps to increase hepatic glycogen; the boiling time is controlled at 12 h, so that not only the processing time is saved and the manpower and the materials resources are saved, but also the relatively high beneficial component content of the product is guaranteed, the toxic and side effects of the product are furthest reduced, and thus the quality of the product is guaranteed; and the processing production method is widely applicable to process and produce polygonum multiflorum.
Owner:广东汇群中药饮片股份有限公司
Probiotics dietary replenisher with function of alleviating type II diabetes, and application thereof
ActiveCN109674060AMitigate or prevent damageHigh activityOrganic active ingredientsBacteriaDietary supplementFreeze-drying
The invention discloses a probiotics dietary replenisher with a function of alleviating type II diabetes, and application thereof. The probiotics dietary replenisher with the function of alleviating type II diabetes is prepared from freeze-drying bacteria powder, active polysaccharide and dietary prebiotics, wherein the freeze-drying bacteria powder is lactobacillus rhamnosus freeze-drying bacteria powder and lactobacillus plantarum X1 freeze-drying bacteria powder. After the bacteria are activated, the bacteria are subjected to enlargement cultivation, centrifugation and washing in sequence,and then, freeze-drying protective agent heavy suspension thalli are added to obtain thallus suspension; after the thallus suspension is pre-frozen, the thallus suspension is frozen and dried to obtain the freeze-drying bacteria powder. The dietary replenisher disclosed by the invention has a high active ingredient content, the viable bacteria content of the probiotics can be 1,011 CFU / g or above,the blood sugar level of a mouse can be lowered, the contents of glycosylated hemoglobin and endotoxin can be obviously lowered, the levels of insulin and hepatic glycogen are improved, and the probiotics dietary replenisher has a wide application prospect.
Owner:苏州微克生活科技有限公司
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