96 results about "Hepatic glycogen" patented technology

The invention belongs to the technical field of medicine-food homologous formula food and particularly relates to special diet for hyperglycemia patients. The reason inducing hyperglycemia is that hepatic glycogen output is increased, too much high-fat food is ingested, the pancreatic islet function can not excellently secrete insulin, and then, the blood sugar content is increased. The traditional Chinese medical science always stresses that dietotherapy is better than medication, so as to avoid injection and medication and even pain of surgery. According to the special diet, whole grains are perfectly combined with medicine-food homologous and new-resource-food traditional Chinese medicines, and diet and health preserving are organically combined so as to regulate, prevent and resist hyperglycemia; probiotics are creatively utilized as a pioneer based on the inheritance of Chinese traditional Chinese medicine treasure treatment methods, and the proliferation of the probiotics is promoted, so that the movement functions of the spleen and stomach are enhanced; and meanwhile, various natural and original ecological medicine-food homologous edible materials are added according to the physical characteristics of hyperglycemia patients, so that the special diet has the unique advantage of integrated dietotherapy, prevention and regulation effects.

The invention provides a separation and purification method of a human umbilical cord mesenchymal stem cell exosome and an application of the human umbilical cord mesenchymal stem cell exosome, and belongs to the technical field of medicines. The human umbilical cord mesenchymal stem cell exosome provided by the invention is prepared by cultivating human umbilical cord mesenchymal stem cells via aserum-free medium, collecting supernatant liquid, implementing centrifuging as well as ultra-filtration and concentration, transferring a concentrated solution onto a 30% sucrose-heavy water densitypad and implementing further purification through sucrose density centrifuging, so that the human umbilical cord mesenchymal stem cell exosome is obtained. According to the separation and purificationmethod that the human umbilical cord mesenchymal stem cell exosome is obtained through separation and purification, immunoreactivity is effectively reduced, and a controllable dosage when the human umbilical cord mesenchymal stem cell exosome is used is guaranteed. The human umbilical cord mesenchymal stem cell exosome, by improving a degree of activating an insulin signaling pathway of a type IIdiabetes animal model, can inhibit composition and decomposition of hepatic glycogen, so that glucose metabolism homeostasis can be achieved; and meanwhile, the sensitivity of the type II diabetes animal model to insulin and an insulin secretion function of pancreatic [beta] cells can be improved and a blood glucose concentration can be reduced, so that the application of the human umbilical cordmesenchymal stem cell exosome to the preparation of medicines for treating type II diabetes can be achieved.

The invention discloses health-care vinegar, a brewing method and hyperglycemic reduction application thereof. The health-care vinegar is prepared from 4 to 7 parts of rice, and 2 to 4 parts of yam. The brewing method comprises the following steps: (1) pulping the rice and yam with water, regulating the starch concentration to be over 10 percent by adopting sterile water or traditional Chinese medicinal extract, and heating the mixture for 5 to 10 minutes at the temperature of between 125 and 130 DEG C; (2) adding rhizopus, activated dried yeast, aroma-producing yeast and lactic acid bacteria into the sterilized mixture to ferment distilled wort, adding lactic acid bacteria seed fermentation broth into the mixture when the alcohol content is detected to be between 6 and 8 percent, leading the fermentation temperature to be between 26 and 34 DEG C, adding edible salt into the mixture when the acidity of the fermentation broth is not changed, and stopping alcoholic fermentation; and (3) ageing the fermented acid solution for over 15 days at the temperature of between 12 and 20 DEG C, and filtering the solution to obtain the health-care vinegar. The brewed health-care vinegar can reduce blood sugar of experimental II type diabetic rats, shows certain dose-response relationship, can improve the insulin sensitivity of the experimental II type diabetic rats, can improve the carbohydrate tolerance of the experimental II type diabetic rats, and improve the content of hepatic glycogen and muscle glycogen.

The invention relates to an anti-fatigue Maca extract and a functional drink including the same. The anti-fatigue Maca extract is prepared from the following raw materials by mass: 0.8 to 1.2 of Maca powder, 0.1 to 0.3 of rhodiola root powder, 0.2 to 0.5 of yacon powder, 0.2 to 0.5 of crab apple powder and 0.08 to 0.12 of mint leaf powder. According to the invention, the Maca, rhodiola root and yacon are blended, so comprehensive anti-fatigue effect is exerted; the crab apple and mint leaf enable the beverage to has sour-sweet, cool and refreshing taste; through microwave treatment of Maca powder, the irritant and pungent taste of Maca beverages can be eliminated; and anti-fatigue accessory factors are added for coordinate regulation of amino acid metabolism, carbohydrate decomposition and lipid metabolism of the body, so body fatigue caused by acute exercises of the human body is regulated, the function of reservation of hepatic glycogen is improved, etc.

The invention relates to anti-fatigue anti-aging compound capsules containing sea cucumber peptides and oyster peptides. The components in each 500mg of capsule contents are as follows: 200-300mg of sea cucumber peptides, 100-200mg of oyster peptides, 50-100mg of maca extractive, 50-100mg of polygonatum sibiricum rhizome extractive, and 5-10mg of astaxanthin. A preparation method comprises weighing raw materials according to proportioning, conducting uniform mixing, conducting sieving with a 100-mesh sieve to obtain mixed powder, and then filling capsule shells with the obtained compound powder by adopting a conventional capsule filling process so as to obtain the compound capsules. The compound capsules prepared by the invention can prolong the weight-bearing swimming time of mice, reducethe blood lactic acid level of the mice after exercise, and increase hepatic glycogen reserve of the mice; and the compound capsules have obvious protection effect on the damage caused by oxidation in the mice of a rapid aging model. Through human test-meal trials, the compound capsules can obviously relieve fatigue symptoms including fatigue, hypodynamia, soreness of waists and legs, and sexualhypofunction. The trials indicate that the compound capsules have good anti-fatigue and anti-aging effects, and have no side effect on human bodies, and can be taken for a long term.

The invention discloses a preparation method of mollugin. The preparation method includes: taking India madder root, and using 5-15 times of petroleum ether to perform heating reflux extraction for 20-40min; recycling petroleum ether, and vacuum drying to remove petroleum ether so as to obtain extract; and subjecting the extract to 200-300-mesh silica gel column chromatography, eluting with petroleum ether, performing TLC (thin layer chromatography) detection, combining components rich in mollugin, subjecting to Sephadex LH-20 gel column chromatography, eluting with mixture of chloroform, petroleum ether, and methanol in mass ratio of 5:5:1, subjecting to silica gel H-column decompression column chromatography, eluting with petroleum ether, and recrystalizing with hot ethanol to obtain the mollugin. The invention further discloses application of the mollugin in preparation of hypoglycemic drugs and preparation of drugs for treating diabetes. Experiments show that the mollugin can effectively reduce blood sugar, TC (total cholesterol), TG (total glycerin) and MDA (methylene dioxyamphetamine) content of mice with high blood sugar caused by alloxan, and can evidently increase SOD (superoxide dismutase) activity and hepatic glycogen content of the mice.

The invention belongs to the technical field of microorganisms, and particularly relates to lactobacillus paracasei with the effects of reducing blood sugar, protecting the oral cavity and resisting depression and application of the lactobacillus paracasei. The lactobacillus paracasei nbk-LC16 provided by the invention has relatively strong acid resistance and cholate resistance, is good in tolerance in artificial gastric juice and artificial intestinal juice, and can effectively reduce blood sugar and inhibit streptococcus mutans. The influence of the lactobacillus paracasei nbk-LC16 on hyperglycemia mice is studied, and after the lactobacillus paracasei nbk-LC16 is perfused, compared with model group mice, the weight of the hyperglycemia mice is remarkably increased in 8W, the liver index and the spleen index are remarkably reduced, FBG and PBG are remarkably reduced, the HbA1c and insulin levels are remarkably reduced, and the hepatoglycogen content is increased. Test results show that the lactobacillus paracasei nbk-LC16 can regulate blood glucose by regulating insulin level and HbA1c and promoting conversion of blood glucose into hepatic glycogen. Researches on the inhibitioneffect of the streptococcus mutans strain on streptococcus mutans show that the streptococcus mutans strain can be effectively inhibited through in-vitro tests and oral test results, and the oral cavity and tooth health can be protected; meanwhile, the anti-depression effect is achieved.

The invention relates to a preparation method of deer blood peptide and its anti-fatigue effect, belonging to the field of medicine. Drying of deer blood: use a spray dryer, adjust the inlet temperature to 180°C, the outlet temperature to 80°C, and the speed to 26,000-30,000 rpm; deer blood protein hydrolysis: the concentration of deer blood protein is 3%, and alkaline protease is used for hydrolysis , The hydrolysis conditions are: temperature 53°C, time 5.5h, pH 9.5, enzyme amount 1272u/g; purification of deer blood peptide: membrane filtration and gel chromatography. In the present invention, the anti-fatigue experiment of mice is used to study the activity of the deer blood peptide. Animal experiments show that the polypeptide produced by the optimal hydrolysis process can significantly prolong the swimming time and low-pressure hypoxia tolerance of mice, the content of liver glycogen is significantly higher than that of the control group, and the content of blood lactic acid is significantly lower than that of the control group; It has good anti-fatigue effect.

The invention discloses a compound dendrobium candidum blood-glucose-reducing capsule. The capsule is prepared from the dendrobium candidum with other seven traditional Chinese medicines, including astragalus, kudzu roots, dried radix rehmanniae, root of Chinese trichosanthes, polygonatum kingianum, fructus lycii and red peony roots, and is prepared through following steps: crushing, extraction, mixing, granulation and packaging. The components influent on each other and work synergistically. The capsule can promote pancreatic [beta] cells to secrete insulin and inhibit pancreatic [alpha] cells to secrete glucagon, and meanwhile can inhibit decomposition of hepatic glycogen due to epinephrine and promote synthesis of the hepatic glycogen, thereby reducing sources of blood glucose, increasing outlet of the blood glucose and reducing a blood glucose value. The capsule is free of toxic and side effect and untoward reactions, and can effectively control and eliminate symptoms, including polyphagia, polydipsia, polyuria and emaciation, in diabetes and diabetic complications.

The invention discloses a traditional Chinese medicine with an anti-fatigue function and a preparation method thereof. The traditional Chinese medicine is prepared from seven traditional Chinese medicinal materials such as rhizoma polygonati, astragalus, American ginseng, medlar, mulberry, donkey-hide gelatin, walnut kernel. The pharmacodynamic test proves that the loaded-swimming time of a mouse can be prolonged, the hepatic glycogen content is increased, the blood urea level is reduced, and the traditional Chinese medicine has an obvious anti-fatigue effect. The safety test proves that the traditional Chinese medicine is high in safety, and the formula is scientific and is suitable for long-term administration.

The invention discloses blood sugar reducing tea rice porridge containing rehmannia root and a preparation method thereof. The tea rice porridge is prepared from 50-60 of glutinous rice, 15-20 of rhubarb root and rhizome rice, 13-18 of green tea, 7-10 of red sorghum, 3-6 of gordon euryale seed, 3-5 of small red beans, 3-5 of rehmannia root, 2-4 of pumpkin leaves, 0.8-1.5 of mulberry leaves, 0.8-1.2 of coptis root, 1-1.5 of pineapple, 0.8-1.5 of apple, 1.2-1.5 of Chinese dwarf cherry leaves, 1.2-1.5 of grosvenor momordica fruit leaves and a defined amount of white granulated sugar. The rice porridge produced by the preparation method has the advantages that the rice porridge has the special fragrance of tea and is tasty; the effective part (R-BP-F) of the added rehmannia root has a good effect on reducing the blood sugar; alkaloid fagomine and polysaccharides contained in the mulberry leaves promote beta cells to secrete insulin; and the insulin can promote utilization of sugar by cells and hepatic glycogen synthesis and improve glycometabolism so as to finally achieve the effect on reducing the blood sugar; and the product also contains various traditional Chinese medicine ingredients beneficial to human bodies and is beneficial to body health after being eaten for a long time.

The present invention relates to a fatigue preventing health-care composition. The composition comprises the following raw materials: Chinese wolfberry fruits, red dates, maca, radix puerariae, American ginsengs, L-carnitine, taurine, selenium-enriched yeast and SOD freeze-dried powder. A preparation method of the composition is as follows: firstly the Chinese wolfberry fruits and red dates are subjected to extraction with water, a water extract is concentrated, the concentrated extract is dried, the dried extract is crushed to obtain powder A; then the maca, radix puerariae and American ginsengs are subjected to extraction with ethanol, an alcohol extract is concentrated to obtain an alcohol extract thick paste, medicinal dregs after the alcohol extraction are boiled with water, the water decoction is concentrated, the concentrated water decoction is mixed evenly with the alcohol extract thick paste, the mixture is dried, and the dried mixture is crushed to obtain powder B; and finally, the powder A, the powder B and other raw materials in the formula are mixed evenly to obtain the fatigue preventing health-care composition. The prepared health-care composition can obviously prolong the weight-bearing swimming time of mice, reduces the blood lactic acid level of the mice after exercises, and increases the reservation of hepatic glycogen in the mice. Through population eating trials, the composition can obviously alleviate or improve the fatigues, sore waist and painful legs, sexual dysfunction and other symptoms.

The invention discloses an extract of an active anti-fatigue part of okra, and a preparation method and application thereof. The extract of the active anti-fatigue part of okra uses total polyphenols as a main active anti-fatigue component, wherein the total polyphenols account for 11.79 to 23.34% of the total mass of the extract of active anti-fatigue part and mainly comprise catechin derivatives and quercetin derivatives, and the quercetin derivatives are mainly composed of quercetin-3-O-gentiobioside, quercetin-3-O-glucose-xyloside, isoquercitrin, quercetin-3-O-malonyl-glucoside, rutin and quercetin. The extract of the active anti-fatigue part of okra provided by the invention can substantially prolong the load swimming time of mice, eliminate lactic acid accumulation after sports, reduce the content of serum urea nitrogen, increase hepatic glycogen and improve the antioxidation capability of mice in a stress state, and has substantial anti-fatigue effect.

The present invention belongs to the field of health-care food and particularly relates to a fatigue preventing health-care food composition and a health-care food preparation. Oligopeptides originated from wheat proteins, soybean proteins and animal collagen are combined, then apricot kernel powder, red date powder, oatmeal and cheese powder ingredients are added for the fatigue preventing health-care food, and the health-care food composition can effectively improve the changes of metabolites of hepatic glycogen content, serum urea nitrogen content, blood lactate acid content, etc. under body fatigue state and effectively improve the body health status.

The invention discloses a lycium barbarum polysaccharide-deer blood composition having functions of relieving fatigue and tonifying yang. Lycium barbarum polysaccharide and a deer blood dry powder asactive components are made into an oral preparation in accordance with conventional excipients and processes of the pharmaceutics, or are made into a food prepared for a meal in accordance with a health-care food process. Experiments show that the composition can significantly prolong the loaded swimming time of small mice, reduce the content of blood lactic acid and serum urea nitrogen after thesmall mice do exercise and increase the reserve amount of hepatic glycogen; compared with the fatigue relieving function of the single use of lycium barbarum polysaccharide and deer blood, the function is more comprehensive, and the effect is more effective. The composition also can significantly enhance the gonadal hormone level of rats and the activity of superoxide dismutase in testis tissues,reduces the content of malondialdehyde, enhances the antioxidant capacity of the rat, and has stronger activity than the activity of lycium barbarum polysaccharide and deer blood groups. Therefore, the composition can be used for enhancing the anti-fatigue and yang-tonifying ability of sub-health young and middle-aged men, as well as conditioning middle-aged and elderly patients with physical deficiency.

The invention relates to the field of medicines, in particular to application of an anoectochilus roxburghii polysaccharide extract. The anoectochilus roxburghii polysaccharide extract is used for preparing an anti-fatigue medicine, the anoectochilus roxburghii polysaccharide extract has obvious anti-fatigue effect and can obviously prolong weight-loading swimming time of a mouse, lower serum lactate dehydrogenase level after swimming, lower serum urea nitrogen content, improve the oxidation resistance of the mouse in a stress state and increase content of hepatic glycogen and muscle glycogen.

The invention relates to the biotechnology field and in particular relates to application of a reduced coenzyme II. Test results show that NADPH can be used for obviously prolonging weight-bearing swimming time of a mouse, increasing reserve of hepatic glycogen of a fatigued mouse and reducing lactic acid and urea nitrogen content of the fatigue mouse, so that the reduced coenzyme II has an obvious anti-fatigue effect.

The invention relates to a liquiritigenin-cyclodextrin or cyclodextrin derivative clathrate, a composition containing the clathrate, and a preparation method and novel application of the clathrate; the application of the liquiritigenin-cyclodextrin or cyclodextrin derivative clathrate in the preparation of drugs for improving or treating exercise-induced fatigue, and the pharmaceutical composition are prepared by the inventor during the study on the liquiritigenin-cyclodextrin or cyclodextrin derivative clathrate by: establishing an animal model, and detecting change levels of hepatic glycogen, blood lactic acid and urea nitrogen in a mouse sample; it is verified that liquiritigenin can resist exercise-induced fatigue, and the pharmaceutical composition for resisting exercise-induced fatigue is prepared.

The invention discloses a probiotics dietary replenisher with a function of alleviating type II diabetes, and application thereof. The probiotics dietary replenisher with the function of alleviating type II diabetes is prepared from freeze-drying bacteria powder, active polysaccharide and dietary prebiotics, wherein the freeze-drying bacteria powder is lactobacillus rhamnosus freeze-drying bacteria powder and lactobacillus plantarum X1 freeze-drying bacteria powder. After the bacteria are activated, the bacteria are subjected to enlargement cultivation, centrifugation and washing in sequence,and then, freeze-drying protective agent heavy suspension thalli are added to obtain thallus suspension; after the thallus suspension is pre-frozen, the thallus suspension is frozen and dried to obtain the freeze-drying bacteria powder. The dietary replenisher disclosed by the invention has a high active ingredient content, the viable bacteria content of the probiotics can be 1,011 CFU/g or above,the blood sugar level of a mouse can be lowered, the contents of glycosylated hemoglobin and endotoxin can be obviously lowered, the levels of insulin and hepatic glycogen are improved, and the probiotics dietary replenisher has a wide application prospect.

A sporting type healthcare slimming beverage and a preparing method thereof are provided. The beverage comprises, by weight, 1-3 parts of betaine, 3-7 parts of oligosaccharide and 1000 parts of water. The beverage according to an embodiment contains the betaine and the oligosaccharide. The oligosaccharide is a natural active compound, has sweetness that is 0.3-0.6 time of sweetness of cane sugar, maintains pure sweet properties of the cane sugar and is more refreshing in sweet taste than the cane sugar. The oligosaccharide can't be directly digested or absorbed by human bodies, and only can be absorbed and utilized by intestinal tract bacteria, and therefore the oligosaccharide does not cause obesity and is a good sweetener. At present the oligosaccharide is relatively ideal sugar used for sporting beverages. Under a situation that osmotic pressure is limited, the oligosaccharide can provide more heat, is fast in stomach passing, is lower in hypoglycaemia reaction after absorption than glucose, and has good effects for maintaining blood sugar levels and supplementing hepatic glycogen.