562 results about "Magnesium stearate" patented technology

The invention discloses an efficient-dissolution dotenorad tablet and a preparation method thereof, and relates to the technical field of tablet preparation. The tablet consists of 5-20 parts of a dotenorad active component, 10-30 parts of a disintegrating agent, 40-70 parts of a filling agent, 0.5-5 parts of a surfactant, 0.5-3 parts of a lubricant, 1-5 parts of an adhesive and 0.5-1 part of an antioxidant. The preparation method comprises the following steps: premixing active components and auxiliary materials, carrying out high-shear wet granulation to form porous structure particles, carrying out precise temperature-control drying through a fluidized bed, carrying out micronization treatment to regulate the specific surface area of the particles, and finally, carrying out high-pressure tablet forming through a magnesium stearate / aerosil compound lubrication system. The dissolution rate of the tablet in a medium with the pH value of 6.8 for 15 minutes reaches 85% or above, meanwhile, long-term stability is achieved by inhibiting oxidative degradation, and the tablet has the dual advantages of quick effect taking and stable storage.

The application discloses a kind of derived biomass hard carbon material pulverization process, belong to biomass charcoal material processing technical field, first, pulverization process includes the following steps: after drying, the coconut shell derived hard carbon block is carried out primary crushing, while spraying first modifier, obtain the particle size 1~3mm of coarse crushing modified particle;Coarse crushing modified particle is carried out secondary precision crushing under argon atmosphere, while spraying second modifier, obtain the precision crushing modified particle of D 50 Particle size is 15 μm;Precision crushing modified particle is carried out roll grinding spheroidization, while spraying third modifier, obtain the spherical modified particle of D 50 Particle size is 10 μm;Spherical modified particle is carried out flash drying after cooling, then add magnesium stearate to it, after mixing, obtain derived biomass hard carbon material.Then, the application realizes breakthrough in tap density, particle size distribution, first efficiency and other core indexes by the coordination of three-stage gradient modification and progressive pulverization process.

The invention provides an antioxidant enzyme-containing composition and a preparation method thereof, and relates to the technical field of enteritis treatment. The preparation method comprises the following steps: S1, collecting various component materials for preparing the antioxidant enzyme-containing composition: collecting various raw materials for preparing glucan, fructo-oligosaccharide, galactooligosaccharide, superoxide dismutase, vitamin C, bunge cherry seed powder, cassia seed powder, turmeric, sorbitol, hydroxypropyl methyl cellulose, silicon dioxide and magnesium stearate; according to the invention, a matched powder bagging machine is adopted to realize full-automatic unattended operation to automatically complete the large bag filling and sealing step in the steps S4-S10, vacuumizing is performed firstly and then sealing is performed, and the storage space is compressed by vacuumizing, so that the condition that the bag is expanded and broken by internal air pressure in the transfer and storage process is not easy to cause; in the bag sealing process, the phenomena of high hot melting efficiency and high sealing speed are achieved by adopting a bag strip guiding and rolling hot melting mode.

The invention relates to the technical field of functional product preparation, and provides a rhizoma polygonati and saussurea involucrata bone marrow peptide tablet as well as a preparation method and application thereof. The rhizoma polygonati and saussurea involucrata bone marrow peptide tablet is prepared from the following components: collagen peptide powder, L-isoleucine, a compound nutrient supplement, rhizoma polygonati, sorbitol, yak bone marrow peptide powder, fructus phyllanthi, fructus alpiniae oxyphyllae, mulberry powder, a saussurea involucrata culture and magnesium stearate. All the components of the rhizoma polygonati and saussurea involucrata bone marrow peptide tablet disclosed by the invention have a synergistic effect, so that the effects of conditioning sub-health, maintaining joints and assisting in treating diseases can be achieved.

The invention discloses a preparation method of perindopril amlodipine tablets, and belongs to the field of pharmacy. The perindopril amlodipine tablet is prepared from the following raw material medicines: arginine perindopril and amlodipine besylate and auxiliary materials: lactose, microcrystalline cellulose, hydrophobic colloidal silicon dioxide and magnesium stearate. The preparation method of the perindopril amlodipine tablet comprises the following steps: weighing according to the prescription amount, crushing and sieving the raw materials for pretreatment, sieving the whole particles of the auxiliary materials for pretreatment, premixing, feeding and total mixing, tabletting and the like. The prepared perindopril amlodipine tablet is relatively good in quality, high in stability and relatively few in waste products.

The invention provides a preparation method of a trazodone hydrochloride sustained release tablet, and belongs to the technical field of medicine processing. The preparation method comprises the following steps: (1) mixing a trazodone hydrochloride raw material medicine, cane sugar, povidone and carnauba wax to obtain a mixture; (2) preparing the mixture into molten particles by adopting a hot-melt extrusion technology; and (3) cooling and sieving the molten particles, adding magnesium stearate, uniformly mixing, and tabletting to obtain the trazodone hydrochloride sustained-release tablet. The trazodone hydrochloride sustained release tablet comprises the following components in percentage by mass: 45%-55% of trazodone hydrochloride raw material medicine, 15%-35% of cane sugar, 5%-15% of povidone, 5%-15% of carnauba wax and 1%-5% of magnesium stearate. According to the invention, a hot melt extrusion technology is adopted, so that the raw materials can be highly dispersed within a short heating time, the loss of the raw materials is avoided, the production cost is reduced, and commercialized production is facilitated.

The invention provides a preparation method and application of low-bath-ratio and high-viscosity hydroxypropyl carboxymethyl composite starch ether, and relates to the technical field of starch deep processing. The method comprises the following steps: S1, premixing corn starch with a compound base catalyst and magnesium stearate, and spraying an ethanol water solution for alkalization; s2, adding epoxypropane to carry out first-stage etherification, and then adding sodium chloroacetate to carry out second-stage etherification; and S3, after the reaction is finished, performing vacuum drying, crushing and sieving to obtain the high-viscosity hydroxypropyl carboxymethyl composite starch ether. Wherein the composite alkali catalyst comprises sodium hydroxide, sodium carbonate and calcium oxide. The starch ether obtained by the method has the advantages of high substitution degree, high viscosity, low solvent consumption and low energy consumption, and overcomes the defects of the traditional semi-dry method.

The invention provides a fat-reducing and weight-reducing food composition, a tablet candy as well as a preparation method and application of the tablet candy, and belongs to the technical field of foods. The fat-reducing and weight-reducing food composition provided by the invention is prepared from the following raw materials in parts by weight: 4 to 8 parts of epigallocatechin gallate, 8 to 16 parts of raw coffee powder, 2 to 6 parts of ginseng peptide powder, 22 to 38 parts of fish oil microcapsule powder, 39.5 to 44.5 parts of a sweetening agent, 3 to 7 parts of a filling agent and 0.5 to 1.5 parts of a lubricating agent. Wherein the sweetening agent is sorbitol, the filling agent is microcrystalline cellulose, and the lubricating agent is magnesium stearate. The food composition can be used for preparing tabletted candies which are good in fat-reducing and weight-reducing effects, good in stability and low in friability.

The invention belongs to the technical field of medicines and health-care products, and discloses an earthworm protein peptide polypeptide tablet with functions of dissolving thrombus and protecting blood vessels. Comprising the following components in parts by mass: 20 to 50 parts of earthworm protein peptide, 30 to 40 parts of sorbitol, 2 to 5 parts of lactose, 2 to 10 parts of freeze-dried natto powder, 2 to 10 parts of rice bran fatty alkanol, 1 to 5 parts of dunaliella salina powder, 1 to 5 parts of bovine myocardial peptide powder, 0.01 to 0.05 part of collagen peptide, 0.01 to 0.05 part of soybean peptide powder, 0.01 to 0.05 part of vitamin B6, 0.04 to 0.12 part of a compound nutrition enhancer, 1 to 5 parts of fructo-oligosaccharide, 0.01 to 0.05 part of magnesium stearate and 0.04 to 0.012 part of a compound coating agent. The earthworm protein peptide polypeptide tablet has the effects of thrombolysis and blood fat reduction, can assist in preventing thrombosis, regulating blood fat metabolism and assisting in reducing cholesterol, and has an antioxidant function.

The invention relates to the technical field of pharmaceutical preparations, in particular to a solid dispersion-based sustained-release drug composite carrier as well as a preparation method and application thereof. The preparation method comprises the following steps: carrying out synergistic spray drying on double polymers (hydroxypropyl methylcellulose acetate succinate and polyvinylpyrrolidone-vinyl acetate copolymer) to form a solid dispersion; compounding with mesoporous silica and calcium silicate for localization, and spraying ethanol to activate pores; calcium stearate and magnesium stearate are sequentially added for lubrication; prefabricating a sustained-release skeleton master batch; and finally, mixing, rolling and forming. According to the method, through hierarchical structural design, the drug stability, the powder fluidity and the release controllability are remarkably improved, the method is suitable for industrial production of the dihydroergoline mesylate sustained release preparation, and a release curve is smooth and reliable.

The invention provides a PEF composite board and a preparation method, and relates to the technical field of insulation boards, the composite PEF board is formed by bonding a plurality of layers of board bodies, and comprises a base layer, the base layer is prepared from the following components in parts by weight: 58 to 60 parts of HDPE (High-Density Polyethylene), 4 to 6 parts of nano montmorillonite, 1 to 2 parts of benzoyl peroxide, 2 to 5 parts of BHT (Butylated Hydroxytoluene) heat stabilizer and antioxidant, 2 to 5 parts of maleic anhydride grafted polyethylene, 0.2 to 1 part of magnesium stearate and 0.3 to 0.8 part of epoxidized soybean oil; comprising a fireproof layer which is composed of the following components in parts by weight: 45-55 parts of HDPE and 5-15 parts of a phosphate ester environment-friendly flame retardant; comprising a thermal insulation layer and is prepared from the following components in parts by weight: 45-55 parts of HDPE, 5-10 parts of lignin fibers and 5-10 parts of a bio-based foaming agent formed by mixing sodium bicarbonate and citric acid. The invention has the beneficial effects that the mechanical strength, flame retardant property and thermal insulation effect of the PEF plate are obviously improved, the weather resistance and environmental protection property are enhanced, the optimal balance of high performance and cost effectiveness is realized, and the PEF plate is suitable for various building and industrial application environments.

The invention discloses a hangover alleviating and liver protecting composition, which is prepared from the following components in parts by mass: 5 to 20 parts of radix puerariae extract, 5 to 20 parts of semen hoveniae extract, 5 to 20 parts of silybum marianum extract, 1 to 20 parts of rhizoma curcumae longae extract, 1 to 20 parts of rhizoma gastrodiae extract, 1 to 10 parts of lucid ganoderma extract, 1 to 20 parts of folium cortex eucommiae extract, 1 to 10 parts of fructus corni extract and 1 to 30 parts of corn oligopeptide powder. 1-50 parts of maltodextrin, 1-10 parts of microcrystalline cellulose, 1-2 parts of silicon dioxide and 1-2 parts of magnesium stearate. The total alcoholism-relieving and liver-protecting composition has the following beneficial effects: for acute drunkenness, the discomfort of drunkenness is obviously reduced, the chronic injury of alcohol to the liver is reduced, the systematic effect from alcohol metabolism to organ protection is realized through multi-target regulation and control, and the three-in-one effect of relieving alcoholism, protecting cells and regulating metabolism is achieved. The invention also discloses a preparation method of the alcohol effect dispelling and liver protecting composition.

The invention discloses a plasmin lumbrukinase peptide dietary therapy formula suitable for rehabilitation of cardiovascular and cerebrovascular diseases, blood circulation promoting, blood stasis removing, thrombolysis, collateral dredging and microcirculation improving, and relates to the technical field of medicine and food homology dietary therapy. Soybean protein isolate and earthworm protein are used as core thrombolytic active raw materials, isomaltooligosacharide, xylitol, German Jilida collagen peptide, soybean peptide powder, Belgian imported inulin, red yeast rice and natto powder are compounded, microcrystalline cellulose and magnesium stearate are used as auxiliary materials, and probiotics / metabiotics strains such as rhamnolactobacilli JYLR-005 and the like can be selectively added. The raw materials have a synergistic effect through precise matching, plasmin and lumbrukinase peptide in earthworm protein can directly dissolve thrombus fibrin, natto powder and red yeast rice assist in lowering lipid and dissolving thrombus, multiple active peptides and prebiotics regulate intestinal microecology to improve microcirculation of the whole body, probiotics / metabiotics further strengthen the metabolic capacity of the body, no chemical medicine is added in the whole process, and the traditional Chinese medicine composition is free of toxic and side effects and free of toxic and side effects. The safety is high; the dietary therapy composition can achieve postoperative rehabilitation conditioning of cardiovascular and cerebrovascular diseases through daily consumption, effectively promote blood circulation to remove blood stasis, dissolve thrombus and dredge collaterals, improve microcirculation and relieve various discomfort caused by blood vessel clogging, raw materials are easy to obtain, compatibility is scientific, and the dietary therapy composition is suitable for large-scale production and popularization.

The invention discloses a procyanidine compound hard capsule for a health food capable of maintaining beauty and keeping young. The procyanidine compound hard capsule is prepared from the following components: a procyanidine extract, chitosan, vitamins, collagen, hyaluronic acid, a lotus leaf extract, astragalus polysaccharide, casein phosphopeptides, D-mannitol, starch, magnesium stearate and gelatin. The invention relates to a production process and application of a procyanidine compound hard capsule for beauty and young keeping health food, and the production process comprises the following steps: step 1, adjusting a formula proportion by using a component proportion optimization model to obtain an optimal preparation effect; 2, solution preparation is conducted on all the components, and the prepared solutions are mixed together; step 3, drying the procyanidine compound solution by adopting low-temperature vacuum drying; and 4, metering the dried procyanidine compound powder by using a capsule filling machine, and sub-packaging the procyanidine compound powder into medicinal hard capsules. The beauty-maintaining, young-keeping and health-care effects are greatly improved.

The invention discloses a high-color-fastness washable polyethylene fabric and a preparation process thereof in the field of functional polymer materials. The high-color-fastness washable polyethylene fabric is prepared from the following raw materials: polyethylene resin, maleic anhydride-acrylic acid copolymer grafted polyethylene, dopamine-silane composite modified polyethylene, magnesium stearate and an antioxidant. Wherein the maleic anhydride-acrylic acid copolymer grafted polyethylene is prepared by copolymerizing maleic anhydride and acrylic acid and then blending and granulating with polyethylene, and carboxyl and acrylate groups are introduced to enhance the binding force with dye; the dopamine-silane composite modified polyethylene is prepared through polyethylene surface hydroxylation, dopamine self-polymerization modification and silane grafting reaction, and the acting force and hydrophobicity between fibers are doubly improved through a catechol group and an epoxy group. According to the prepared fabric, the color fastness and the washing resistance are remarkably improved, meanwhile, the original characteristics of light weight and chemical corrosion resistance of polyethylene are kept, and the application scene is expanded.

The invention belongs to the technical field of medicines, and particularly relates to a fenerenone orally disintegrating tablet and a preparation method thereof. The active component of the fenerenone orally disintegrating tablet is fenerenone, and the fenerenone orally disintegrating tablet comprises the following components in percentage by weight: 10-15% of fenerenone, 10-15% of magnesium stearate, 10-15% of magnesium stearate and the balance of 70-80% of a filler; 5.5-10% of a disintegrating agent; 1-4% of a flow aid; and 1-4% of a lubricant. The finerenone orally disintegrating tablet disclosed by the invention is suitable for being taken by diabetics, and has the advantages of high disintegration and dissolution speed, stable finished product quality, no need of being taken with water and strong patient compliance; in addition, the finerenone orally disintegrating tablet disclosed by the invention is simple in preparation process, low in cost and suitable for large-scale production.

Systems and methods are described for fiber-based, plastic-free products for storage of emulsion food products. In some embodiments, a coating is applied to the product, such as a coating comprising efficacious proportions of xylitol, citric acid, water, microfibrillated cellulose, and polyvinyl alcohol. A slurry is used to fabricate the product includes various proportions of fiber blends (e.g., combinations of bleached softwood, bleached hardwood, kraft paper, and / or virgin fiber), AKD, starch, a stearate (e.g., Magnesium or Calcium Stearate), a defoamer, and microfibrillated cellulose.

The present invention discloses an orange enhanced masterbatch and a preparation method thereof, belonging to the technical field of polymer material coloring. The method includes mixing and ball-milling a pigment with a modified coupling agent, adding magnesium stearate and then sand-milling to obtain a color paste; mixing the color paste with PP, antioxidant, plasticizer and light stabilizer and carrying out intensive mixing; then extruding and pelletizing through a twin-screw extruder to obtain a pretreated masterbatch; finally drying and screening to obtain the orange enhanced masterbatch. Compared with the prior art, the present invention is prepared by a specific synthesis process, enhancing the compatibility between the pigment and PP, and improving the dispersibility and aging resistance of the masterbatch. The masterbatch of the present invention has excellent color uniformity, stability and aging resistance, and is applicable to the field of high-performance plastic coloring.

The invention relates to a nintedanib dry powder inhalant as well as a preparation method and application thereof. The dry powder inhalant comprises nintedanib and magnesium stearate. According to the nintedanib dry powder inhalant, by controlling the adding proportion of magnesium stearate and the particle size distribution of co-micro powder, the dosage of fine particles can be remarkably increased, the nintedanib dry powder inhalant still has the high dosage of fine particles under the high drug loading capacity, the drug bioavailability is high, and the safety risk of a patient in the medication period can be reduced. Meanwhile, the preparation method of the nintedanib dry powder inhalant is simple and controllable, and the final product is safe, reliable and high in stability.

The invention relates to the technical field of preparation of barium sulfate powder, and discloses a preparation process of aluminum hydroxide modified barium sulfate powder, which comprises the following steps: constructing high-density sulfate radical active sites through argon plasma activation, and combining with a bio-based coupling agent to realize triple chemical bonding of barium sulfate and aluminum hydroxide; dynamically controlling hydrolysis of the aluminum salt by adopting microwave pulse in cooperation with a spiral microreactor to generate a nanoscale aluminum hydroxide uniform coating layer; supercritical CO2 is introduced to synchronously regulate and control the pH and the anti-solvent effect, side reaction is inhibited, and coating compactness is optimized; a closed-loop aluminum salt recovery system is combined to realize resource cyclic utilization; finally, the application performance of the powder is improved through hydrophobic treatment of magnesium stearate. Compared with a traditional acid pickling activation and continuous heating process, the chemical pollution risk is avoided, the bonding strength of a coating layer is improved by 60% or above, the utilization rate of aluminum salt reaches 98%, and the powder hydrophobicity and the plastic processing adaptability are remarkably optimized.

The invention relates to the field of medicines, and discloses slow-release composite powder for removing nitrite and a preparation method thereof, and the slow-release composite powder comprises the following raw materials: bovine bone collagen peptide, sorbitol, L-sodium ascorbate, L-alanine composite powder, vitamin E, earthworm protein, natto powder, cranberry powder and magnesium stearate. Wherein the L-alanine composite powder is prepared from L-alanine, y-aminobutyric acid and L-glutamic acid; according to the present invention, the L-alanine composite powder and the active substance can chemically react with the nitrite in the body so as to convert the nitrite into the safe substance to be discharged out of the body, such that the absorption and the adsorption of the nitrite can be easily reduced, and the formation of the nitrite in the digestive tract can be reduced so as to reduce the concentration of the nitrite in the body; and nitrite is directly prevented from being accumulated to the level of potential health hazards.

The invention discloses a sports nutrition solid food for supplementing protein and a preparation method, and belongs to the technical field of foods.The sports nutrition solid food is prepared from, by weight, 31-60 parts of compound amino acid powder, 10-15 parts of isomaltitol, 1-6 parts of taurine, 1-5 parts of Chinese yam peptide, 5 parts of glycine, 5 parts of gamma-aminobutyric acid, 5 parts of L-lysine hydrochloride and 1 part of yeast protein powder. The formula comprises the following components in parts by weight: 1-3 parts of whey protein powder, 1-2 parts of hydroxymethyl propyl cellulose, 0.1-1 part of yeast extract, 0.1-1 part of yeast beta-glucan, 2-6 parts of bovine colostrum powder, 0.5 part of stevioside, 0.1 part of zinc glycinate, 0.1 part of ferrous lactate, 0.5 part of essence and 2-3 parts of magnesium stearate. The compound amino acid powder, the Chinese yam peptide, the glycine, the L-lysine hydrochloride, the yeast protein powder, the whey protein powder, the yeast extract and the bovine colostrum powder are compounded, so that protein consumed by a human body after exercise can be comprehensively supplemented.

The invention relates to an anti-aging capsule compounded by PQQ and mitochondrial nutrients, and discloses an anti-aging capsule which is prepared by synergistically compounding a plurality of mitochondrial nutrients according to a scientific proportion and supplementing high-purity raw materials and slow-release dosage forms to realize energy metabolism activation and anti-oxidation synergistic intervention. Therefore, the anti-aging capsule systematically delays aging through multi-target regulation and control of mitochondrial functions. The capsule is characterized by comprising the following components in parts by weight: 1-20 mg of pyrroloquinoline quinone disodium salt (PQQ), 20-100 mg of coenzyme Q10, 50-200 mg of L-carnitine tartrate, 10-100 mg of alpha-lipoic acid, 50-300 mg of nicotinamide mononucleotide (NMN) or nicotinamide nucleoside (NR), and 10-50 [mu] g of selenoprotein or organic selenium yeast, and a capsule carrier comprises 100 mg of gelatin or a plant-derived capsule shell, 180 mg of microcrystalline cellulose, 5 mg of magnesium stearate and 5 mg of silicon dioxide.

The invention relates to a fluralan soft chewable tablet for pets and a preparation method of the fluralan soft chewable tablet. The fluralan soft chewable tablet comprises the following raw materials: 14.0% of fluralan, 0.3%-1.0% of lauryl sodium sulfate, 1.0%-3.0% of magnesium stearate, 5.0%-10.0% of polyethylene glycol, 3.0%-5.0% of cane sugar, 0.05%-0.5% of a preservative, 10.0%-22.0% of a phagostimulant, 4.0%-10.0% of a release agent, 11.0% of glycerol, 13.8% of soybean oil and the balance of corn starch. The chewable tablet soft material disclosed by the invention is obviously improved in the aspects of state, wall sticking condition, demolding condition and forming, conventional existing equipment is adopted, the process is simple and feasible, and a sample is stable in microbial limit level in a long-term placement process and meets standard requirements.

The invention discloses a midodrine hydrochloride tablet and a preparation method thereof, and belongs to the field of medicine preparation, the midodrine hydrochloride tablet comprises midodrine hydrochloride, ethyl cellulose, hydroxypropyl methylcellulose, lactose, microcrystalline cellulose and magnesium stearate; the preparation method comprises the following steps: sieving ethyl cellulose with a 80-mesh sieve; sieving other raw materials with a 100-mesh sieve; the preparation method comprises the following steps: dissolving ethyl cellulose in absolute ethyl alcohol, fully stirring, and adding trimethylhydroxysilane; adding midodrine hydrochloride into the absolute ethyl alcohol containing ethyl cellulose and hydroxypropyl methylcellulose, and stirring to form wet particles; the wet particles are subjected to ultraviolet radiation; mixing the wet granules with lactose, microcrystalline cellulose and magnesium stearate to prepare tablets; performing drying treatment on the tablets; according to the midodrine hydrochloride tablet and the preparation method thereof disclosed by the invention, the slow-release effect can be improved under the condition that a small amount of ethyl cellulose is used, and the problem of insufficient slow-release effect in the prior art is solved.

The invention discloses an astragaloside synergistic type composition as well as a preparation method and application of the astragaloside synergistic type composition. Comprising the following components: 8 to 16 parts of astragaloside, 20 to 40 parts of a honeysuckle flower extract, 10 to 20 parts of L-carnitine, 0.1 to 0.5 part of selenium yeast, 3 to 8 parts of diammonium glycyrrhizinate, 5 to 15 parts of taurine, 8 to 20 parts of a fructus forsythiae extract, 2 to 7 parts of vitamin E, 12 to 32 parts of hydroxypropyl-beta-cyclodextrin, 2 to 10.5 parts of maltodextrin, 1 to 7 parts of Arabic gum, 10 to 20 parts of lactose, 1 to 3 parts of zinc gluconate and 2 to 5 parts of magnesium stearate. 1-3 parts of vitamin C, 1-5 parts of xanthan gum and 1-3 parts of lecithin. The composition has a wide application prospect in preparation of veterinary drugs or veterinary food additives.

The invention provides a sustained-release pellet containing gamma-aminobutyric acid, the sustained-release pellet comprises a pellet core and a coating layer wrapping the pellet core, the pellet core contains a physiologically active substance, and the physiologically active substance is gamma-aminobutyric acid; the pellet core comprises the following components in parts by weight: 15-40 parts of gamma-aminobutyric acid, 30-55 parts of a filling agent, 1-30 parts of a lubricating agent and 0.5-5 parts of an anti-caking agent; the filling agent comprises at least one of microcrystalline cellulose, powdery cellulose, starch and derivatives thereof, hydroxypropyl cellulose, hydroxypropyl methylcellulose, low-substituted hydroxypropyl cellulose, sugar or sugar alcohol and fruit and vegetable powder; the lubricant comprises at least one of talcum powder, magnesium stearate, stearic acid, glycerol and leucine; the anti-caking agent comprises at least one of magnesium carbonate, tricalcium phosphate, calcium hydrophosphate and silicon dioxide.

The invention discloses a mianserin hydrochloride tablet prepared in a wet granulation mode. The mianserin hydrochloride tablet is prepared from mianserin hydrochloride anhydride, calcium hydrogen phosphate, corn starch, hydroxypropyl methylcellulose, colloidal silicon dioxide, magnesium stearate and a film coating agent. According to the mianserin hydrochloride tablet and the preparation method thereof, the stability of the mianserin hydrochloride tablet is improved by using the high-concentration adhesive solution and optimizing the granulation parameter range, the problem that related substances are increased due to crystal transformation of active ingredients in the product preparation process is solved, and the medication safety of patients is better guaranteed.

The invention discloses a preparation method of Kyoho grape young fruit polyphenol buccal tablets and a product thereof. The method comprises the following steps: (1) preparing grape young fruit powder: adding 0.1-0.3% of a Vc protective agent and 15-20% of a maltodextrin drying aid into Kyoho grape young fruits, homogenizing, filtering, adjusting the solid concentration to 15-25%, performing spray drying, and collecting the young fruit powder; and (2) tabletting buccal tablets: taking 1.5-3.0 parts by weight of young fruit powder, 4-6 parts by weight of corn starch, 3-5 parts by weight of glucose, 0.1-0.3 part by weight of Vc and 0.08-0.12 part by weight of magnesium stearate, mixing, tabletting and forming. According to the method, the problem of resource waste caused by the fact that young fruits of Kyoho grapes in the fruit thinning period cannot be eaten due to high acerbity is solved, meanwhile, the problem that the young fruits adhere to the wall is solved through optimization of a spray drying process, efficient utilization of polyphenol active ingredients and high-value utilization of the young fruits of the grapes are achieved, and planting economic benefits are improved.

The invention relates to the technical field of food processing, and particularly discloses a heart and cerebral vessel health care composition with thrombolytic and antithrombotic functions and a preparation method thereof. The composition consists of the following raw materials: sorbitol, red yeast rice, freeze-dried natto powder, earthworm protein peptide, vitamin C, American ginseng peptide, magnesium stearate, an angelica sinensis extract, rice bran fatty alkanol, vitamin B1, vitamin B2, a turmeric extract and a compound coloring agent. The preparation method comprises the following steps: mixing the raw materials except magnesium stearate in a double-cone mixer; magnesium stearate is added for continuous mixing, and a hollow capsule shell is filled with the mixed material. The composition disclosed by the invention forms a multi-dimensional synergistic system for smoothing blood vessels, purifying blood and improving blood flow, the defect of single effect of an existing product is overcome, the health-care effect of heart and cerebral vessels is remarkably improved, and the effect is stable and controllable; in addition, the preparation method has the advantages of being simple and controllable in process and suitable for industrial production.