1385 results about "Microcrystalline cellulose" patented technology

The invention belongs to the field of pet deodorization, and particularly relates to pet shower balm containing natural deodorization extracts and lasting in fragrance and a preparation method of the pet shower balm. The shower balm for pets comprises the following raw materials: a persimmon extract, silica, an emulsifier, an antioxidant, a hard water ion chelating agent, a thickening agent and a solubilizer. The preparation method comprises the following steps: mixing the persimmon extract and the silica to obtain a solution A; mixing coconut oil, olive fruit oil and glycerol to obtain a solution B; adding sodium polyacrylate and microcrystalline cellulose into water, and dissolving; adding a hard water ion chelating agent, and mixing to obtain a mixed solution; and finally, adding the mixed solution into the solution A and the solution B, mixing, cooling, adding the antioxidant, and stirring. The persimmon extract and the silica have a very good removal promoting effect, and have a good application prospect.

The invention discloses thermophilic fungus cleavable polysaccharide monooxygenase and application thereof, and belongs to the technical field of enzyme engineering and microbial engineering. The thermophilic fungus lysing polysaccharide monooxygenase provided by the invention has excellent thermal stability; when the lysable polysaccharide monooxygenase is used for synergistically hydrolyzing phosphoric acid swelling cellulose, microcrystalline cellulose and bagasse, the enzymolysis rate is increased, and the problems of poor thermal stability of the lysable polysaccharide monooxygenase, low enzymolysis rate of synergic cellulase and high LPMOs enzyme dosage are solved. The method has high practicability and can be widely applied to the enzymolysis process of various cellulosic substrates, so that the enzymolysis efficiency of the cellulosic substrates is remarkably improved.

The invention relates to the technical field of plastics, in particular to an antibacterial food packaging bag and a preparation method thereof.The antibacterial food packaging bag is prepared by blending polylactic acid and polypropylene carbonate as a base film raw material, selecting a food-grade ADR chain extender as a chain extender, selecting one of butyl titanate and a titanate coupling agent as a compatibilizer and selecting composite hybrid cellulose as a broad-spectrum antibacterial agent; carrying out extrusion granulation and blow molding to obtain a base film; the preparation method comprises the following steps: taking microcrystalline cellulose-nano zinc oxide hybrid particles as hybrid cellulose, performing epoxidation on the hybrid cellulose by using epoxy chloropropane, and then grafting an amino acid-based Schiff base antibacterial agent by using epoxy-hydroxyl reaction; composite hybrid cellulose and modified castor oil-based waterborne polyurethane are used for preparing a protective coating, the surface of a base membrane is coated with the protective coating, and a green, environment-friendly, durable, antibacterial, hydrophobic and antifouling self-repairing surface is constructed.

The present invention relates to the technical field of pharmaceutical preparations, and specifically discloses a beclomethasone dipropionate suspension for inhalation and a preparation method thereof. The present invention uses polyethylene glycol hyaluronic acid as a surfactant, polysorbate 80 (II) as a wetting agent, and colloidal microcrystalline cellulose as a suspending agent, first prepares an auxiliary material solution containing part of the surfactant, the wetting agent and the suspending agent, and a drug solution of beclomethasone dipropionate and the surfactant, and then mixes the drug solution with the auxiliary material solution and homogenizes under high pressure to prepare the beclomethasone dipropionate suspension for inhalation. The prepared beclomethasone dipropionate suspension has excellent storage stability and effective lung deposition rate, effectively solves the potential harm to respiratory tissue caused by the use of a large amount of Tween 20 and Span-type surfactants in the original research, can achieve a good replacement for the original research product, and has a simple preparation process, good repeatability, and is easy to achieve industrialized large-scale production, and has a high value of promotion and application.

The invention discloses an ovarian protection composition containing ergothioneine and a preparation method of the ovarian protection composition, and relates to the technical field of ovarian protection compositions. The ovary protection composition containing the ergothioneine is prepared from the following components in parts by mass: 0.1 to 0.5 part of the ergothioneine, 0.05 to 1 part of S-equol, 1 to 5 parts of reducing coenzyme Q10, 1 to 3 parts of vitamin E, 10 to 20 parts of chitosan oligosaccharide, 30 to 50 parts of microcrystalline cellulose, 3 to 8 parts of hydroxypropyl methyl cellulose, 0.5 to 2 parts of silicon dioxide and 0.5 to 2 parts of a stabilizer. By adopting the stabilizer, photooxidation and hydrolysis of sensitive components are inhibited through molecular action, and the long-term stability of the composition in a humid and hot environment is remarkably improved in combination with the physical barrier action of silicon dioxide. Through the antioxidant synergistic effect of the ergothioneine and the vitamin E, the hormone regulation effect of the S-equol and the energy metabolism improvement effect of the coenzyme Q10, a multi-layer ovarian function protection system is constructed, and the health state of ovaries is improved. Through a special process, the tablet can be rapidly disintegrated and slowly released in an intestinal targeted manner, burst release of active ingredients is avoided, and the absorption efficiency is improved.

The invention provides a preparation method and application of polypyrrole graphene oxide hydrogel with an anisotropic structure. The preparation method comprises the following steps: adding sodium hydroxide and urea into water according to a certain proportion, adding microcrystalline cellulose into an alkali urea solution, uniformly stirring, and repeatedly freezing and thawing to obtain a cellulose solution; adding graphene oxide into water for cell disruption and dispersion to obtain a uniform graphene oxide solution; adding the graphene oxide solution into the cellulose solution, then adding an epichlorohydrin cross-linking agent, and carrying out stirring treatment, centrifugation and low-temperature standing to form gel; and pre-stretching the hydrogel to a certain length, immersing the hydrogel into a dilute sulphuric acid solution, taking out the hydrogel, adding pyrrole, carrying out polymerization growth in a closed environment, taking out the hydrogel, soaking the hydrogel in water, and washing the hydrogel to obtain the anisotropic polypyrrole graphene oxide hydrogel. The anisotropic polypyrrole graphene oxide cellulose hydrogel disclosed by the invention has excellent solar photo-thermal water evaporation performance and also has excellent thermal management performance.

The invention provides a degradable biological membrane and a preparation method thereof. The degradable biological membrane is prepared from the following raw materials in parts by weight: 60-70 parts of PBAT, 30-40 parts of PLA, 5-10 parts of microcrystalline cellulose composite modified particles, 0.5-2 parts of a chain extender, 1-2 parts of a coupling agent, 0.5-1 part of an anti-hydrolysis agent and 0.5-1 part of an antioxidant. The degradable biological membrane is obtained through the working procedures of mixing, extrusion granulation, curtain coating cooling, two-way stretching and the like. Wherein the microcrystalline cellulose is modified through the procedures of carboxylation, cross-linking, monohydroxyl end-capping grafting and the like at a specific degree to prepare composite modified particles, so that the degradable biological membrane has good mechanical properties and waterproof and breathable functions.

A coating composition for a substrate, which includes: a microcrystalline cellulose composition, at least one silane, at least one acid catalyst, a liquid dispersion phase, and optionally at least one inorganic filler. Also, the use of this composition for the release coating of a substrate such as a paper surface or a metal surface. Finally, an article having at least one surface is coated with the coating composition.

The invention discloses an organic wastewater treatment agent and a preparation method thereof, and relates to the field of water treatment materials. When the organic wastewater treatment agent is prepared, nano silicon dioxide sequentially reacts with a silane coupling agent 4140, sodium periodate, p-phenylenediamine and dimethyl phosphite, and modified nano silicon dioxide is prepared; the preparation method comprises the following steps: reacting modified nano silicon dioxide with 2, 4, 6-triformyl phloroglucinol and 2, 4-diamino-6-methoxypyrimidine, so as to prepare functionalized nano silicon dioxide; the preparation method comprises the following steps: reacting microcrystalline cellulose with thionyl chloride, N-(glycidyl)-N-phenyl-ethylene oxide methylamine and thiourea in sequence to prepare modified cellulose; and reacting the modified cellulose with the functionalized nano silicon dioxide to prepare the organic wastewater treatment agent. The organic wastewater treatment agent prepared by the invention has the capabilities of resisting bacteria, adsorbing anionic pollutants, adsorbing cationic pollutants and photocatalytically degrading organic pollutants.

The present invention relates to the technical field of EVA, and discloses a preparation method of a wear-resistant modified EVA foamed sole material, ethylene-vinyl acetate copolymer, POE grafted microcrystalline cellulose, ethylene propylene diene monomer rubber, auxiliary agent, filler, cross-linking agent, foaming agent are placed in an open mill, and molded foaming is carried out in a flat vulcanizer after mixing to obtain a wear-resistant modified EVA foamed sole material. POE can play the role of a compatibilizer, improve the interface compatibility between microcrystalline cellulose and EVA, improve the tensile strength, elongation at break and tear strength of the foamed material, and reduce the relative volume wear amount, improve wear resistance. And reduce water absorption, improve the water resistance and waterproof performance of the foamed sole material.

The present invention provides a betahistine antioxidant tablet and a preparation method thereof, the betahistine antioxidant tablet comprises: a first zone comprising anhydrous citric acid, microcrystalline cellulose and hydroxypropyl methylcellulose; the middle buffer area is a sodium alginate aqueous solution coating; a second zone including calcium carbonate, betahistine, and microcrystalline cellulose; the first zone is located at the top of the tablet, the second zone is located at the bottom, and the buffer zone physically isolates the first zone from the second zone. The first zone, the buffer zone and the second zone are designed to form a sandwich structure, oxidation resistance is realized through dual mechanisms of physical isolation and chemical neutralization, and CO2 generated by reaction of food-grade citric acid and calcium carbonate is used for physically replacing oxygen.

The invention discloses a preparation method of flexible hydrogel and application of the flexible hydrogel in a pressure sensor, and belongs to the field of flexible sensors. According to the hydrogel disclosed by the invention, polyvinyl alcohol and regenerated cellulose are used as a hydrogel skeleton, and carboxylated carbon black is doped as a conducting medium. The preparation method comprises the following steps: carrying out carbonization treatment on microcrystalline cellulose in a tubular furnace at high temperature to obtain high-conductivity carbon black; then, functional groups are introduced into the carbon black through modification treatment; the method comprises the following steps: dissolving paper pulp in N-methylmorpholine-N-oxide (NMMO), and carrying out cooling, solidification, dialysis and other process treatments to obtain regenerated cellulose; the flexible conductive hydrogel is obtained by adding conductive carbon black and regenerated cellulose into a PVA solution with a certain concentration and introducing sodium tetraborate at the same time. The regenerated cellulose in the hydrogel is rich in a large number of hydrogen bonds, and the flexibility and the self-healing performance of the hydrogel are remarkably improved through the interaction among the hydrogen bonds. The method disclosed by the invention is simple to operate, the prepared hydrogel has better elasticity, self-healing property and conductivity, and the practical application of the hydrogel in the field of flexible sensors is widened.

The invention relates to an alprazolam oral solid composition and a preparation method thereof. In one aspect, the invention relates to an alprazolam tablet, which is prepared by preparing premixed particles containing alprazolam in advance and then preparing the tablet by a wet granulation and tabletting method. The premixed particles comprise alprazolam, microcrystalline cellulose and the like, and the tablet further comprises microcrystalline cellulose, corn starch, silicon dioxide, magnesium stearate and the like. The alprazolam tablet disclosed by the invention can be used as a medicine for resisting anxiety, tension, depression, excitation, hypnosis, panic, relieving acute alcohol withdrawal symptoms and resisting drug-induced intractable hiccup, and has certain excellent performance.

The invention provides melogabalin besylate tablets and a preparation method thereof. The melogabalin besylate tablets comprise melogabalin besylate, a filler, a disintegrating agent, an acid stabilizer, an antioxidant, a lubricant, a flow aid and a gastric-soluble film coating agent. The antioxidant comprises gallic acid, the acid stabilizer comprises maleic acid, and the filler comprises directly pressed starch, isomaltitol, mannitol and microcrystalline cellulose. By screening the antioxidant and the acid stabilizer, the stability of the tablet in the storage period is improved.

The invention relates to the technical field of pharmaceutical preparations, in particular to a preparation process of carbon dots for killing helicobacter pylori and application of the carbon dots in oral pharmaceutical preparations. The preparation method comprises the following steps: mixing microcrystalline cellulose and glycerol, freezing and crushing at an ultralow temperature, and selectively hydrolyzing by combining citric acid-malic acid mixed acid liquor to efficiently prepare a high-crystallinity cellulose nanocrystal template; the controllable synthesis of the carbon dots is realized by utilizing the hydrogen-bond interaction of hydroxyl / carboxyl on the surface of the cellulose nanocrystal and the nitrogen doping effect in the polymerization and carbonization process of citric acid and urea. Besides, when a sodium alginate-chitosan double-layer structure is constructed, carbon dots are introduced into the inner layer to endow the inner layer with special performance, a protein-polysaccharide network is formed on the outer layer through transglutaminase enzymatic crosslinking, and the oxidation resistance and mechanical strength are enhanced through secondary curing of tea polyphenol. According to the invention, food-grade raw materials are used for realizing high-efficiency antibiosis, the oral preparation safety specification is met, and the clinical transformation potential is realized.

The invention belongs to the technical field of jam processing, and provides a preparation method of Longtan pearl plum low-sugar jam, which comprises the following steps: ripening / sorting fruits; cleaning and denucleating; blanching; performing color protection and pulping; concentrating and blending; carrying out hot filling and sealing; performing sterilization; cooling to obtain a finished product. During concentration and blending, a coagulant aid is added firstly, then citric acid is added, a pectin solution is added finally, the coagulant aid is composed of CaCl2 and chromium-enriched yeast, and the pectin solution is formed by compounding low-methoxyl pectin, starch sodium octenylsuccinate, microcrystalline cellulose and sodium alginate. According to the invention, through improvement of a preparation process technology, including pretreatment blanching, addition of a browning inhibitor to inhibit browning, selection of a proper composite thickening agent, and bridging formed by polyvalent metal ions and carboxyl groups in pectin molecular chains, a relatively good gelling effect is achieved, and through combined action of multiple aspects, the problem of bleeding of the low-sugar pearl plum jam is solved; meanwhile, the low-sugar pearl plum jam product with excellent appearance, taste and nutrition is obtained.

The invention belongs to the technical field of pharmaceutical preparations, and particularly relates to a capsule containing oseltamivir phosphate and application of the capsule. The capsule is composed of oseltamivir phosphate, turmeric, microcrystalline cellulose, sorbitol, povidone and a lubricant, and the prepared capsule is good in dissolution effect, high in quality, low in content of related substances and suitable for further clinical application.

In order to solve the problems that an existing acrylic polymer barrier coating for a paper-based material is insufficient in mechanical strength and prone to breeding bacteria, the invention provides a barrier coating composition for the paper-based material, a barrier coating and a paper base material. The barrier coating composition for the paper-based material comprises the following components: a water-based acrylic prepolymer, chitosan grafted polyvinyl alcohol, an inorganic filler, microcrystalline cellulose, water-based polyurethane, a polysiloxane grafted acrylic monomer, an epoxy group-containing acrylic monomer, 1, 4-butanediol diacrylate and a solvent. The barrier coating composition for the paper-based material provided by the invention has excellent water vapor barrier property and grease barrier property, and more importantly, the barrier coating composition for the paper-based material provided by the invention has relatively good antibacterial property on the premise of having excellent mechanical property, so that the barrier coating composition for the paper-based material provided by the invention can be used as a barrier coating for the paper-based material. The method is suitable for various food paper-based packaging products such as disposable paper cups, paper bowls and food boxes, and the food safety performance of the food paper-based packaging products is improved.

The invention discloses a combined processing technology of catalytically cracked gasoline, which belongs to the technical field of petrochemical engineering, and comprises the following steps: cutting the catalytically cracked gasoline into light component gasoline and heavy component gasoline; mixing the light-component gasoline with alkali liquor, continuously extracting with the alkali liquor, and collecting refined light-component gasoline; mixing the heavy-component gasoline with a hydrodesulfurization catalyst, carrying out hydrodesulfurization reaction, and collecting refined heavy-component gasoline; and mixing the refined light-component gasoline and the refined heavy-component gasoline to obtain a low-sulfur catalytically cracked gasoline product. The reinforcing material, the modified macroporous alumina, the organosilicon, the microcrystalline cellulose and the chitosan are mixed to form a cross-linked network structure aerogel as a hydrodesulfurization catalyst, stress generated under thermal shock of catalytically cracked gasoline can be absorbed and reduced, and the mechanical strength of the hydrodesulfurization catalyst is improved; the hydrodesulfurization catalyst has a large surface area and a porous structure, so that the specific surface area of the hydrodesulfurization catalyst is increased, and the desulfurization efficiency of the hydrodesulfurization catalyst is further improved.

The invention provides a fat-reducing and weight-reducing food composition, a tablet candy as well as a preparation method and application of the tablet candy, and belongs to the technical field of foods. The fat-reducing and weight-reducing food composition provided by the invention is prepared from the following raw materials in parts by weight: 4 to 8 parts of epigallocatechin gallate, 8 to 16 parts of raw coffee powder, 2 to 6 parts of ginseng peptide powder, 22 to 38 parts of fish oil microcapsule powder, 39.5 to 44.5 parts of a sweetening agent, 3 to 7 parts of a filling agent and 0.5 to 1.5 parts of a lubricating agent. Wherein the sweetening agent is sorbitol, the filling agent is microcrystalline cellulose, and the lubricating agent is magnesium stearate. The food composition can be used for preparing tabletted candies which are good in fat-reducing and weight-reducing effects, good in stability and low in friability.

The invention relates to the field of aquatic feed, and provides a low-temperature adhesive type aquatic feed particle composition and a preparation method thereof. The composition is composed of puffed soybean meal, flour, fish meal, low-temperature directed enzyme, microcrystalline cellulose, modified zein nanoparticles, a protein adhesive and a modified zein ethanol water solution. The preparation method comprises the following specific steps: reacting soybean protein isolate with cross-linking enzyme to generate a protein adhesive, reacting proanthocyanidins with gallic acid to generate gallic acylated proanthocyanidins, and carrying out multi-step treatment on zein. Experimental results show that the composition has excellent water resistance and oxidation resistance, and the growth efficiency and the survival rate of aquatic animals are remarkably improved. The preparation method is simple, the cost is low, heat-sensitive substances in the feed are not damaged, and an economical, efficient and nutrient-rich feed solution is provided for aquaculture.

The invention relates to the technical field of nerve calming granules, and discloses sugar-free blood nourishing and nerve calming granules and a preparation method thereof.The sugar-free blood nourishing and nerve calming granules are composed of hairyvein agrimony, prepared rehmannia roots, vine of multiflower knotweed, yerbadetajo herbs, rehmannia roots, suberect spatholobus stems, cortex albiziae and sugar-free auxiliary materials; comprising microcrystalline cellulose, isomaltitol, mannitol, nano silicon dioxide, Arabic gum, hydroxypropyl methyl cellulose and polyvinylpyrrolidone. By optimizing the proportion and process conditions of the auxiliary materials and the synergistic effect of the medicinal material extract and the auxiliary materials, the humidity of the wet granules is controlled to be 30-35%, the granulation pressure is 3-6 MPa, the drying temperature is 50-55 DEG C, and finally the granules with the particle size of 200-400 microns are prepared. According to the invention, the problems of poor particle formability and insufficient disintegration performance caused by removal of sugar are overcome, rapid disintegration, good formability and stability of sugar-free particles are realized, the solubility and taste of the particles are improved, and the sugar-free granules are suitable for long-term administration by diabetics and sugar-sensitive people.

The invention discloses a granular detergent composition, a preparation method thereof and washing beads, and relates to the technical field of daily chemical washing products. The granular detergent composition is prepared from the following components in percentage by mass: 10.0%-30.0% of an anionic surfactant, 5.0%-10.0% of a nonionic surfactant, 3.0%-7.0% of an adhesive, 1.0%-3.0% of a wrapping agent and the balance of a washing assistant, the granular detergent composition is composed of an inner core and a wrapping outer layer wrapping the inner core, the inner core comprises an anionic surfactant, a nonionic surfactant, a washing assistant and an adhesive, and the wrapping outer layer is a wrapping agent; the adhesive is composed of polyethylene glycol 8000 and microcrystalline cellulose. The granular detergent composition disclosed by the invention is good in formability and solubility, and can be quickly disintegrated after meeting water, so that the problem of slow dissolution of granules is solved.

The invention relates to the technical field of layered materials, in particular to an antibacterial layered composite elastic fabric and a preparation method thereof. The defects that an existing layered fabric is poor in antibacterial property and elasticity are overcome. The preparation method comprises the following steps: preparing modified spandex fiber yarns by taking polytetrahydrofuran ether glycol, diphenylmethane diisocyanate and modified microcrystalline cellulose as raw materials; preparing modified polyester fiber yarns by taking terephthalic acid, ethylene glycol, 1, 4-butanediol, isophthalic acid and nano silicon dioxide as raw materials; plying the modified polyester fiber yarns and the modified spandex fiber yarns, and weaving to obtain an outer-layer fabric; performing pretreatment, dipping and heat treatment on the outer layer fabric to obtain an outer layer finished fabric; performing dipping and heat treatment on the inner-layer fabric to obtain an inner-layer finished fabric; the antibacterial layered composite elastic fabric obtained by laminating and compounding the outer-layer finishing fabric and the inner-layer finishing fabric has strong antibacterial property and strong elasticity, and is suitable for manufacturing outdoor textiles.

The invention relates to the technical field of coatings, and discloses a wear-resistant thin-layer water-based coating and a preparation method thereof.The water-based coating is prepared from, by weight, 100 parts of waterborne polyurethane, 5-25 parts of sodium sulfonate modified cellulose, 0.6-1 part of a defoaming agent, 3-5 parts of a coalescing agent, 5-8 parts of pigment filler and 1.4-2.3 parts of a dispersing agent. The modified cellulose contains a sodium sulfonate hydrophilic group, the water solubility of the cellulose is improved, the cellulose is better in dispersity in the water-based paint and free of precipitation, the storage stability of the paint is excellent, and microcrystalline cellulose is uniformly dispersed in the water-based paint and has a good enhancement effect on a polyurethane paint film; meanwhile, cellulose contains a rigid phenyl maleimide ring, so that the structural stability is high, the strength is high, and the impact resistance, the hardness and the wear resistance of a paint film are favorably improved.

The invention discloses a ganoderma lucidum liver-protecting pill and a preparation method thereof, and the ganoderma lucidum liver-protecting pill comprises the following components: 8-20% of ganoderma lucidum polysaccharide extract, 5-15% of coptis chinensis extract, 4-10% of pulvis fellis saponin extract, 3-8% of oriental wormwood, 2-8% of taurine, 1-3% of vitamin E and 2-6% of scleroprotein (ganoderma lucidum sclerotium extract). The auxiliary materials comprise microcrystalline cellulose, corn starch, licorice extract, polyvinyl alcohol and the like, and the balance is 100%. Therefore, the problem of ingredient inactivation caused by traditional high-temperature / solvent extraction is solved through process innovation (such as supercritical CO2 pressure 300bar / enzymolysis pH 5.0 parameter optimization), the dissolution rate is increased to be more than or equal to 90% in 30 minutes (traditional pills need 45 minutes and only 75%), the limitation of single ingredient liver protection is broken through through the synergistic effect of the composite ingredients, and the liver protection effect is improved. Animal experiments prove that a liver injury marker ALT / AST can be reduced by more than 50%, the hepatic fibrosis area can be reduced by 40%, the degradation rate of the active ingredients within 6 months in a stability test is less than or equal to 5%, and the comprehensive bioavailability is improved by 30% compared with that of a traditional product.

The invention relates to a cyclodextrin composition capable of improving the dissolving property of a medicine and a preparation method of the cyclodextrin composition. The cyclodextrin composition capable of improving the dissolving property of the medicine comprises the following components in parts by mass: 15-30 parts of cyclodextrin, 5-15 parts of microcrystalline cellulose, 5-20 parts of modified calcium carbonate, 1-3 parts of silicon dioxide, 1-2 parts of salt and 1-5 parts of an auxiliary agent, wherein the modified calcium carbonate is obtained by reacting cyclodextrin, organic acid, a hydrophilic high-molecular polymer and calcium carbonate. According to the invention, cyclodextrin and microcrystalline cellulose are adopted as main bodies and are compounded with modified calcium carbonate and other components, so that the cyclodextrin composition capable of improving the drug solubility is obtained, the dissolvability of the product is remarkably improved, a better release effect is achieved, the defects in the prior art are overcome, and the cyclodextrin composition has important significance on development and popularization of the cyclodextrin composition product and has wide application prospects. The application prospect is good.

The invention relates to the technical field of pharmaceutical preparations, and provides an oral solid preparation for treating gout and a preparation method thereof. The preparation method comprises the following steps: sieving a filling agent, a disintegrating agent, an adhesive and dotenorad to obtain a sieved material; and mixing the sieved material and a lubricant, and tabletting to obtain the oral solid preparation for treating gout, the filling agent is lactose, mannitol and microcrystalline cellulose. By optimizing the prescription and the preparation process, the dissolution rate and bioavailability of the medicine are improved, so that the curative effect is improved; by selecting proper auxiliary materials and preparation types, the stimulation to gastrointestinal tracts is reduced, and the tolerance of patients is improved; the oral solid preparation is convenient to take, accurate in dosage, high in patient compliance and beneficial to long-term treatment; moreover, the preparation method provided by the invention is simple to operate, easy for industrial production and relatively low in cost.

The invention discloses a degradable nanocellulose sustained-release drug-loaded film and a preparation method thereof, and belongs to the technical field of drug functional materials. The preparation method comprises the following steps: mixing and stirring microcrystalline cellulose and 64wt% sulfuric acid solution, centrifuging, dialyzing to be neutral, and freeze-drying to obtain CNCs; cNCs, NaIO4 and water are mixed and then subjected to a light-shielding reaction, ethanol precipitation is added, dialysis purification is conducted, freeze drying is conducted, and formylation modified CNCs are obtained; mixing and stirring the aldehyde modified CNCs, sericin, polyvinyl alcohol, water and a target drug to obtain a core layer solution; dissolving a polylactic acid-glycolic acid copolymer into a mixed solution of chloroform and DMF (Dimethyl Formamide) to obtain a shell solution; the core layer solution and the shell layer solution are subjected to coaxial electrostatic spinning forming to obtain the drug-loaded fiber, then the drug-loaded fiber is subjected to biomimetic mineralization surface modification to obtain the degradable nanocellulose sustained-release drug-loaded film, the drug loading rate is increased, the mechanical property of the drug-loaded film is improved, and the sustained-release and release-controllable effects are achieved.

The invention relates to a polyacid composite oil-controlling and acne-removing gel and a preparation method thereof, and belongs to the technical field of skin care products. The polyacid composite oil-controlling and acne-removing gel is prepared from the following components in percentage by mass: 2% of salicylic acid, 3%-4% of glycolic acid, 0.5%-1.5% of mandelic acid, 0.5%-1.0% of lactobionic acid, 0.5%-1.0% of gluconolactone, 1.2%-1.6% of microcrystalline cellulose (and) sphingomonas fermentation product extract (and) cellulose gum, 2%-5% of butanediol, 0.3%-0.5% of asiaticoside-II, 0.5%-1.5% of centella asiatica, 0.5%-1.5% of vitamin E and the balance of water. And the balance of deionized water. By adding micro-crystalline cellulose (and) sphingomonas fermentation extract (and) cellulose gum, system stability under compounding of five organic acids is realized, semitransparent gelatinous texture is obtained, the composition is suitable for point coating use mode, impression is not affected, oil-controlling and acne-removing effects are improved under the condition of low organic acid content, and the composition belongs to skin-care polyacid products and has a broad market prospect. The mild oil control and acne removal effects are realized, and the cream is suitable for oil-sensitive skin crowds.