116 results about "Microcrystalline cellulose" patented technology

This invention provides a breathable plaster matrix for application and its preparation method, belonging to the field of polymeric dressings and plasters. The plaster matrix raw materials include terpene-modified rosin beeswax, hydrogenated rosin glyceryl ester, camellia oil, castor oil, stearic acid hydrophobically modified microcrystalline cellulose, zinc oxide, glycerin, coated citric acid, sodium bicarbonate, polyethylene glycol, camphor, and menthol. The terpene-modified rosin beeswax is prepared by reacting rosin and α-pinene in the presence of di-tert-butylperoxyisopropylbenzene, followed by the addition of white beeswax and maleic anhydride, and then the addition of trimethylolpropane. The stearic acid hydrophobically modified microcrystalline cellulose is microcrystalline cellulose coated with stearic acid. The coated citric acid is citric acid coated with hydrogenated castor oil. This invention's plaster matrix significantly improves skin breathability, application comfort, and biocompatibility while ensuring sufficient adhesion, formability, and drug loading capacity.

This invention discloses a highly active compound health supplement made from Cordyceps sinensis, Artemisia argyi, and rhubarb, and its preparation method, belonging to the field of health food and pharmaceutical preparation processing technology. The method includes: adding artificial Cordyceps sinensis ultrafine powder, prepared Rhubarb tanguticum fine powder, Artemisia argyi leaf extract, microcrystalline cellulose PH102, and maltodextrin into a mixer and premixing at 25-35 rpm to allow the powder to adhere to the surface of the excipients; after tableting, the tablets are subjected to ultra-high pressure treatment at 350-380 MPa. This invention achieves uniform distribution and performance optimization of the formulation components without damaging the activity of heat-sensitive components through precise coupling of premixing strength and ultra-high pressure modification parameters. Experiments show that the obtained formulation has an adenosine retention rate ≥96%, a dissolution rate ≥85% after 5 minutes, and excellent moisture resistance and mechanical strength, solving the technical problems of large activity loss, easy moisture absorption, and slow dissolution in traditional formulations.

This invention relates to the field of nutritional food technology, specifically to a fat-reducing composition for regulating the gut and its preparation method. The fat-reducing composition for regulating the gut comprises the following components by weight percentage: 20-25% solid coconut diglyceride microcrystalline powder, 15-20% fermented gel freeze-dried powder, 3-5% citrus pectin, 8-12% psyllium husk powder, 10-15% defatted coconut powder, 5-8% resistant dextrin, 8-10% pea protein powder, 3-5% freeze-dried mango powder, 4-7% erythritol, 1-2% microcrystalline cellulose, and 0.5-1% citric acid powder. This invention effectively solves the core problems of traditional fat-reducing products—poor ingredient stability, low bioavailability, and limited efficacy—through the dual progressive effects of physical structure and biological fermentation. It systematically achieves a synergistic effect of delaying fat digestion and absorption, long-lasting satiety enhancement, and precise regulation of gut microbiota health, completing a systematic engineering leap from single-component stimulation to simulating human metabolic pathways. This provides a stable, efficient, and safe complete solution for fat-reducing functional foods that regulate the gut.

This invention relates to the field of coating technology, specifically to a protective coating for stone surfaces with good waterproof performance and its preparation method, comprising the following steps: S1. Treating microcrystalline cellulose to obtain product 1 for later use; S2. Reacting product 1 from step S1 with titanium tetrachloride to obtain nano-titanium dioxide for later use; S3. Mixing the nano-titanium dioxide from step S2 with sodium oleate and adjusting the pH to 6.5-7.5 to obtain product 2 for later use; S4. Performing surface synergistic hydrophobic modification treatment on product 2 to obtain functional filler. This invention discloses a protective coating for stone surfaces with good waterproof performance, using fluorinated acrylic resin as the base resin, incorporating functional filler, and combining it with a curing agent, mixed solvent, defoamer, and leveling agent. Through the synergistic effect between the components, this protective coating for stone surfaces possesses good waterproof performance as well as good resistance to ultraviolet aging and acid corrosion.

The application discloses sewage treatment composite purifying agent and a preparation method and application thereof, and comprises the following steps: S1, nanometer aluminum powder is mixed with zeolite and is ball milled to obtain nanometer aluminum powder@zeolite inclusion compound; S2, chitosan is dissolved in acetic acid solution, and mercapto acetic acid is added to react to obtain mercapto chitosan; then the mercapto chitosan is dissolved in acetic acid solution, and a trivalent iron source solution is added dropwise to obtain mercapto chitosan-trivalent iron coordination gel; S3, tea saponin is mixed with beta-cyclodextrin to obtain tea saponin-beta-cyclodextrin inclusion compound; S4, porous ceramic granules, nanometer aluminum powder@zeolite inclusion compound, mercapto chitosan-trivalent iron coordination gel, microcrystalline cellulose and citric acid are uniformly mixed, water is added to granulate to obtain an inner core; S5, sulfur powder is melted, carbonate powder, maifanite powder and tea saponin-beta-cyclodextrin inclusion compound are added to obtain molten slurry, the inner core is added, and stirring is carried out to coat, so that the sewage treatment composite purifying agent is obtained; the sewage treatment composite purifying agent can stably remove various pollutants with high efficiency and can adapt to complex water bodies.

Abstract: A biodegradable polymer composi on, according to the present inven on, comprises polyhydroxybutyrate and poly(3- hydroxybutyrate-co-3-hydroxyhexanoate) blended with thermoplas c starch, one or more compa bilizers selected from the group consis ng of dihexyl sodium sulfosuccinate and maleic anhydride, and one or more addi ves selected from the group consis ng of microcrystalline cellulose and cellulose. Methods of producing a biodegradable polymer use processed cannabis waste as a carbon source. Abstract:

This invention belongs to the technical field of filtration aids for food-grade enzyme preparation production, specifically relating to a composite filter aid comprising food-grade diatomaceous earth, food-grade expanded perlite, microcrystalline cellulose, food-grade silica powder, food-grade calcium carbonate, food-grade magnesium carbonate, hydroxypropyl methylcellulose, a diatomaceous earth porous framework compound modified with a low-adsorption sodium alginate pectin silica hydration layer for glucose oxidase, a perlite microcrystalline cellulose chitosan tannic acid-bridged gradient pore modification compound, and food-grade silica. Its preparation includes preparation of a basic mixture, preparation of a composite mixture, drying and cooling, and sieving. This invention forms a loose and stable filter cake, reduces filtration resistance, and improves the filtration speed, filtrate clarity, and enzyme activity retention rate of the glucose oxidase production solution.

The application belongs to the technical field of pharmaceutical preparations, and discloses a trimetazidine hydrochloride tablet and a preparation process thereof.The trimetazidine hydrochloride tablet is composed of trimetazidine hydrochloride, lactose, microcrystalline cellulose, sodium crosslinked carboxymethyl cellulose and other auxiliary materials, and specific auxiliary components are added simultaneously.The preparation process comprises the following steps in sequence: pretreatment of core components, inclusion and dispersion, mixing of soft materials, granulation, drying, total mixing and tablet pressing, and the solubility and dispersibility of the drug are effectively improved.The trimetazidine hydrochloride tablet can realize rapid and sufficient release of the drug, has excellent content uniformity, provides precise and stable dose guarantee for clinical medication, and meets the clinical treatment requirements.

This application discloses a jujube seed and Ganoderma lucidum film-coated tablet and its preparation method. The film-coated tablet uses jujube seed and Ganoderma lucidum in a weight ratio of (2.9–3.1):2 as active raw materials, employs a microcrystalline cellulose and erythritol compound as fillers, and combines them with silica, magnesium stearate, and a specific composite film-coating agent. The preparation method includes raw material pretreatment, water extraction, vacuum concentration, vacuum drying, fluidized bed granulation, total mixing and tableting, and film coating, optimizing each process parameter. This application solves the technical problems of existing traditional Chinese medicine extracts, such as high hygroscopicity, poor compressibility, poor stability, and unclear synergistic effects. The prepared product has high active ingredient content, good stability, rapid disintegration, and good patient compliance, making it suitable for large-scale industrial production and possessing good market application prospects.

The present application relates to the technical field of polypropylene materials, in particular to a wear-resistant modified polypropylene plastic for turnover boxes and a preparation method thereof.The wear-resistant modified polypropylene plastic for turnover boxes comprises the following raw materials in parts by weight: polypropylene 70-80 parts, polypropylene-g-maleic anhydride 3-8 parts, lubricant 1-3 parts, modified talc powder 10-15 parts, titanium dioxide 4-8 parts, microcrystalline cellulose 5-10 parts, and epoxidized ultraviolet absorber 0.5-2.0 parts.The present application prepares the wear-resistant modified polypropylene plastic by compounding polypropylene, polypropylene-g-maleic anhydride, lubricant, modified talc powder, titanium dioxide, microcrystalline cellulose and epoxidized ultraviolet absorber, which not only has excellent mechanical properties, but also has excellent aging resistance and antibacterial properties, thereby prolonging the service life.

This invention belongs to the field of biopharmaceutical technology and discloses a tranexamic acid sustained-release composition, its preparation process, and its application. By weight, the composition comprises 100-120 parts tranexamic acid, 14-18 parts sustained-release material, 5-8 parts magnesium stearate, 2-5 parts colloidal silica, and 3-5 parts polyvinyl alcohol. The sustained-release material is selected from a combination of hydroxypropyl cellulose and ethyl cellulose, or a combination of hydroxypropyl methyl cellulose and microcrystalline cellulose, or a combination of sodium carboxymethyl cellulose and hydrogenated vegetable oil. This invention utilizes the synergistic effect of the sustained-release material and the synergistic effect between the sustained-release material and polyvinyl alcohol to maintain zero-order or first-order release of the drug, achieving a steady-state blood drug concentration and prolonging the duration of action, thereby achieving a good sustained-release effect.

The application discloses a composition containing guarana and a preparation method and application thereof. The application provides a composition containing guarana, which comprises the following raw materials in mass fractions: 2-50 parts of microcrystalline cellulose, 0.5-5 parts of inorganic salt, 5-50 parts of guarana extract, 2-20 parts of organic acid, 1-20 parts of vitamin, 0.2-10 parts of sweetening agent, 1-10 parts of inorganic alkali, 1-10 parts of humectant, 2-10 parts of essence, 1-10 parts of menthol and 0.1-2 parts of cooling agent, with the total weight of all the raw materials being 100 parts. The composition containing guarana is convenient to eat, has a quick and long-lasting refreshing effect, has a good taste, and is not easy to be hardened, and has a good bioavailability.

This invention relates to an utpatinib sustained-release tablet and its preparation method, belonging to the field of pharmaceutical formulation technology. The sustained-release tablet comprises a core and a coating layer. The core is formed by mixing and pressing drug-containing sustained-release particles with excipients. The drug-containing sustained-release particles are prepared by wet granulation and drying of utpatinib hemihydrate, hydroxypropyl methylcellulose, and small-particle-size microcrystalline cellulose, with the residual moisture content of the particles controlled at 1.0%–3.0% (w / w). The excipients include anhydrous citric acid, large-particle-size microcrystalline cellulose, lubricant, flow aid, and mannitol. This invention effectively solves the problems of utpatinib solubility being greatly affected by pH, unstable release, and easy tablet cracking under high hardness by constructing a synergistic system of pH adjustment and gel density, and by utilizing anhydrous citric acid to create an acidic microenvironment and enhance the strength of the HPMC gel layer, combined with the internal and external division of labor between small-particle-size and large-particle-size microcrystalline cellulose.

This invention belongs to the field of pharmaceutical formulation technology and discloses a baloxavir derivative tablet, its preparation method, and its application. The tablet comprises a surface-acidified passivated magnesium aluminum silicate carrier, baloxavir ester, poloxamer 188, microcrystalline cellulose, and magnesium stearate. During preparation, anhydrous citric acid is used to neutralize the basic active sites of pure magnesium aluminum silicate to construct micro-acidic channels. Subsequently, the carrier, baloxavir ester, and poloxamer 188 are mixed and heated, causing the polymer to melt, encapsulate the drug, and penetrate into the mesopores of the carrier. Finally, forced quenching treatment is performed to confine the drug in an amorphous or nanocrystalline state within the channels. This invention blocks the alkaline-catalyzed degradation pathway of baloxavir ester, maintains the high free energy state of the drug through physical spatial confinement, improves the in vitro dissolution rate, and enhances the flowability of the compressed powder.

A moisture-proof acetyl-L-carnitine, comprising not less than 10% of acetyl-L-carnitine, or a hydrochloride thereof, or a mixture of both by weight. The preparation method comprises mixing the following components by prescription amount: acetyl-L-carnitine, or a hydrochloride thereof, or a mixture of both, one or more adjuvants selected from microcrystalline cellulose, compressible starch, lactose or mannitol, one or more adjuvants selected from silicon dioxide, magnesium stearate, calcium hydrogen phosphate, calcium silicate, and micro-powder silica gel; granulating; obtaining the moisture-proof acetyl-L-carnitine. The moisture-proof acetyl-L-carnitine is formulated into a nutritional supplement, a food, a beverage, or an animal feed.

This invention belongs to the field of food processing technology, specifically relating to a processing technology for low-fat meat products based on gelation technology. The process includes: dispersing polysaccharide gel components and microcrystalline cellulose in water, heating to swell, and then cooling to form a composite gel system; introducing air bubbles through mechanical stirring and controlling temperature to solidify and form a porous gel; improving pore wall stability through low-temperature regulation and gel aging treatment; obtaining micron-sized porous gel particles through low-shear granulation; vacuum impregnating a high-viscosity hydrophilic polysaccharide solution with shear-thinning properties under reduced pressure; mixing the obtained porous gel particles with minced meat, shaping, and heating to obtain the low-fat meat product. This invention, by constructing a porous gel structure to store lubricating factors, achieves gradual release during chewing. Without adding any exogenous oils, the coefficient of friction is reduced by more than 20%, effectively solving the technical problems of dry texture and poor lubricity in low-fat meat products, and has good industrial application prospects.

This application relates to the field of composite materials, specifically disclosing a reinforced PC-glass fiber composite material and its preparation method, comprising the following raw materials: PC, aminated glass fiber, antioxidant, lubricant, dispersant, light stabilizer, toughening agent, and epichlorohydrin-modified microcrystalline cellulose; wherein the toughening agent uses nano-silica as the core material, acrylic acid, methyl methacrylate, and glycidyl methacrylate as monomers, and terminal epoxy-terminated polybutadiene as a dopant to polymerize to obtain a polymer shell; the preparation method includes the following steps: mixing epichlorohydrin-modified microcrystalline cellulose with a dispersant to obtain a premix; then melt-blending the premix with other raw materials, extruding, cooling, drying, and pelletizing to obtain the reinforced PC-glass fiber composite material. This application has the characteristics of improving the toughness of the glass fiber-PC composite material while also having higher strength.

This invention relates to a paraquat granule and its preparation method, belonging to the field of pesticide technology. The granule consists of paraquat salt, a layered double hydroxide carrier, a disintegrant, microcrystalline cellulose, an outer coating of an emetic / odorant / tracking agent, and the remainder being water-soluble filler. The granule wear rate is ≤2%, it completely disintegrates within 60 seconds in standard hard water at 25℃, and the suspension rate is ≥90%. Preparation employs a one-step process of screw extrusion-centrifugal granulation-vacuum belt drying or fluidized bed granulation, resulting in high content retention. The product is dust-free and non-caking, suitable for drone-based aerial spraying and long-distance sea transport, facilitating large-scale application in overseas registered areas.

The application relates to the field of high polymer materials and discloses a preparation method of a foaming piece for preventing collapse of an automobile handrail. The foaming piece is constructed by using polytetrahydrofuran ether glycol and a chain extender to form a polyurethane shape memory matrix and by doping nano microcrystalline cellulose modified by isocyanate group silane. The modified filler is dispersed in the crosslinked network to block the slipping of molecular chains, and the matrix is combined with the thermal shape memory function to make the foaming piece actively recover residual deformation under the triggering of heat, so that anti-collapse support is provided. The preparation method matches the reaction rates of foaming gas production and gel setting through a double-catalyst system, and controls the closed cell rate and the core-surface density difference of the foaming piece through a short-time high-speed mixing process, so that the filler is uniformly dispersed, and finally, the foaming finished product with uniform internal and external structures and meeting the basic tensile strength is prepared.

The application provides a multi-color-changing pill core, a preparation method and application thereof. The multi-color-changing pill core is composed of a pill core core layer, a plurality of pigment layers and an intermediate layer arranged between each pair of adjacent pigment layers. The color-changing temperature of the plurality of pigment layers gradually increases from outside to inside, and the color of the plurality of pigment layers gradually disappears from outside to inside, so that a plurality of colors are visually presented in sequence. Moreover, the intermediate layer can reduce color distortion caused by color superposition between adjacent pigment layers. The pill core core layer is prepared from low-thermal-conductivity material, polyvinylpyrrolidone and microcrystalline cellulose, so that the occurrence of color returning is delayed, and the strength, toughness and processing performance of the pill core core layer are improved. Therefore, the multi-color-changing pill core has the characteristics of multi-color-changing, low friability, high roundness and the like, and can meet different application and processing requirements of the cigarette filter rod, and can also meet different consumption habits, so as to improve the consumption experience of the cigarette.

The application provides a preparation method of astaxanthin cordyceps militaris fine tablets, comprising the following steps: subjecting cordyceps militaris fruiting bodies to supercritical CO2 extraction treatment to separate a cordyceps militaris terpene component; mixing Haematococcus pluvialis powder and edible vegetable oil, adding the cordyceps militaris terpene component and rosemary extract, and cooling and forming to obtain an astaxanthin-cordyceps militaris terpene blend; crushing the residue after extraction, adding purified water and a composite enzyme preparation to perform enzymolysis to obtain an enzymolysis liquid; adding a chitosan quaternary ammonium salt solution, centrifuging after flocculation, vacuum drying, and crushing to obtain cordyceps militaris active powder; mixing and granulating raw materials to obtain granulation particles; uniformly mixing the granulation particles with xylitol and microcrystalline cellulose, and pressing into tablets; and placing the tablets in a coating machine for coating. The application realizes efficient retention of active ingredients, improvement of safety and stability of product quality through the cooperation of multiple technologies such as supercritical CO2 extraction, enzymolysis flocculation, low-temperature fluidized bed granulation and hot melt coating.

The application provides a fermenting beverage of Sparassis and a preparation method thereof, which is prepared by fermenting Sparassis extraction liquid with microcapsules. The microcapsules have an asymmetric structure, one side of which is a dense hydrophobic layer composed of Brazil palm wax, shea kernel oil and microcrystalline cellulose, and the inside of which is embedded with glucose, sodium bicarbonate and glucose oxidase, and the other side of which is a loose hydrophilic layer composed of inulin and a composite gel of gellan gum, and the inside of which is loaded with composite lactobacillus. The microcapsules can protect lactobacillus from the stress of inhibiting components and high viscosity polysaccharides in the extraction liquid in the early stage of fermentation, guarantee the rapid proliferation of the bacterial body, trigger the gas production reaction through the metabolic products, and realize self-driven fermentation. The application effectively breaks the mass transfer barrier, relieves the environmental stress, thereby maintaining the high activity of the bacterial body, and comprehensively improves the fermentation efficiency.

The invention relates to a pharmaceutical dosage form for oral administration comprising (i) an intragranular phase, which comprises Sertraline or a physiologically acceptable salt thereof; one or more intragranular fillers (preferably selected from one or more sugar alcohols or sugars; preferably mannitol or lactose, more preferably mannitol); one or more intragranular antioxidants (preferably selected from butylated hydroxytoluene (BHT), butylated hydroxy anisole (BHA), tocopherol or derivatives thereof, ascorbic acid or derivatives thereof, sodium metabisulphite, propyl gallate, sodium thiosulphate, or any combination thereof, more preferably ascorbic acid); (ii) an extragranular phase, which comprises one or more extragranular fillers (preferably mannitol, microcrystalline cellulose, lactose, or any combination thereof); and (iii) optionally, a film coating. The invention further relates to a process for manufacture by wet granulation, wherein the antioxidant is preferably dissolved in the granulation liquid.

The application relates to the field of medicine preparation, in particular to a sirolimus enteric microcapsule granule and a preparation method thereof. The sirolimus enteric microcapsule granule comprises the following components in parts by weight: 0.1-0.5 parts of sirolimus, 50-80 parts of microcrystalline cellulose, 5-10 parts of an inner layer coating material and 3-8 parts of an outer layer coating material; the inner layer coating material comprises carboxymethylcellulose, and the outer layer coating material comprises Eudragit L100-55. The application is characterized in that the outer layer coating is composed of Eudragit L100-55, so that the granule can smoothly pass through the stomach and reach the intestines; the inner layer coating material is composed of carboxymethylcellulose, after the outer layer coating is dissolved in the intestines, the carboxymethylcellulose absorbs water and expands to form a viscous gel layer, so that the drug release is delayed, and the blood drug concentration can be maintained for a long time.

This invention belongs to the field of microbial technology, and discloses a highly efficient anaerobic fungal strain for degrading lignocellulose in the rumen of Dulong cattle, its cultivation method, and its applications. The strain is *Neisseria gonorrhoeae*. Joblinomyces apicalis DLM2, deposited at the China Center for Type Culture Collection (CCTCC) under accession number CCTCC NO: M 20252927, was isolated from the rumen of Dulong cattle and can be stably cultured under strictly anaerobic conditions. This strain possesses a single-centered cell line and filamentous rhizoids, enabling it to efficiently degrade lignocellulose through a synergistic effect of physical colonization and enzymatic degradation. It exhibits broad adaptability to natural straws such as rice straw and bamboo branches, as well as purified substrates such as microcrystalline cellulose and cellobiose. Its enzyme production exhibits substrate-inducible properties, and fermentation produces various metabolites including formic acid, acetic acid, and ethanol, demonstrating high lignocellulose degradation efficiency. This invention relates to an inoculum containing this strain and its application in lignocellulose degradation, roughage fermentation, agricultural straw resource utilization, and biomass conversion, providing new strain resources and technical support for the efficient degradation and resource utilization of lignocellulose.

This invention discloses a highly efficient double-layer coating method for fried meat products, relating to the field of meat processing technology. The method includes the following steps: Step 1, Raw material pretreatment: Select livestock and poultry meat products, wash, cut into pieces, marinate, and surface dry until the surface moisture content is ≤8%, then set aside. Step 2, Base coating preparation: A base coating is prepared by combining octenyl succinate starch ester and zein in a mass ratio of 9.5:0.5, along with 1-3% microcrystalline cellulose, 2-4% cross-linked starch, 0.5-1.2% sodium bicarbonate, and 0.1-0.3% citric acid, mixed at high speed for 10-15 minutes. This highly efficient double-layer coating method for fried meat products anchors the base coating through electrostatic adsorption and forms a hydrogen-bonded interlocking structure between the base coating protein and the batter colloid. Combined with rapid low-temperature cold air setting, the three-layer gradient coating is tightly bonded to the surface of the meat product, significantly improving the coating adhesion and structural integrity, fundamentally improving problems such as easy detachment, cracking, and delamination during frying, transportation, and reheating.

This invention relates to a nanocrystalline cellulose-modified cement mortar composite material and its preparation method, comprising the following steps: (1) purifying and oxidizing commercial microcrystalline cellulose to obtain nanocrystalline cellulose; (2) dispersing the nanocrystalline cellulose in an aqueous solution; and (3) mixing the nanocrystalline cellulose dispersion with cement and standard sand to obtain the nanocrystalline cellulose-modified cement mortar composite material. The composite material prepared by this invention uses hydrogen peroxide to oxidize and modify the nanocrystalline cellulose, increasing the hydroxyl content to improve mechanical properties and to a certain extent solving the problem of nanocrystalline cellulose agglomeration. An appropriate amount of nanocrystalline cellulose can improve the hydration degree of cement paste through hydroxyl water absorption and complexation reactions, optimize the composition of hydration products, reduce the porosity of cement mortar, reduce damage cracks, and improve the mechanical properties of cement mortar.