695 results about "Amination" patented technology

The invention belongs to the technical field of bioengineering, and relates to a transaminase mutant, a recombinant genetically engineered bacterium and application of the transaminase mutant in catalytic synthesis of (R)-1-Boc-3-aminopiperidine.The transaminase mutant is obtained by conducting single-point or combined mutation on the 131 site and / or the 197 site of an amino acid sequence shown in SEQ ID NO.2; the mutation sites comprise that the 131 phenylalanine is mutated into aspartic acid, threonine or tyrosine, and / or the 197 lysine is mutated into arginine or leucine. Experimental results show that compared with wild type transaminase, the catalytic activity, the thermal stability and the organic solvent tolerance of the obtained mutants, especially single-point mutants MyTA1-F131Y and MyTA1-K197R and a combined mutant MyTA1-F131Y-K197R, are all remarkably improved, and compared with the wild type transaminase, the catalytic activity, the thermal stability and the organic solvent tolerance of the obtained mutants are all remarkably improved. The mutant MyTA1-F131Y-K197R can be used for efficiently catalyzing asymmetric amination of N-Boc-3-piperidone to synthesize (R)-1-Boc-3-aminopiperidine, the conversion rate of the (R)-1-Boc-3-aminopiperidine after the (R)-1-Boc-3-aminopiperidine reacts for 24 hours under the condition that the substrate concentration is 100 g / L can reach 90% or above, and the mutant MyTA1-F131Y-K197R has a good industrial application prospect.

The application provides a crosslinked polyethylene insulating material with intrinsic self-repairing and recyclable characteristics, a preparation method and application thereof, and relates to the technical field of cable materials.The crosslinked polyethylene insulating material with intrinsic self-repairing and recyclable characteristics is prepared from the following components in parts by weight: 99.7 parts by weight of low-density polyethylene, 1.0-2.6 parts by weight of peroxide, 0.1-0.5 parts by weight of antioxidant, 5-20 parts by weight of maleimide monomer, 0.35-0.7 parts by weight of catalyst, 0.5-3.0 parts by weight of ligand and 0.5-3.0 parts by weight of furan-based small molecule.The low-density polyethylene is functionally modified through catalytic amination reaction, so that the chain breaking and crosslinking in the modification process are avoided, and the mechanical properties, insulating properties and dielectric properties of the crosslinked polyethylene are enhanced through the post-absorption of the introduced peroxide.Meanwhile, the dynamic reversible Diels-Alder reaction introduced by the post-absorption of the furan-based small molecule enables the polyethylene insulating material to have good intrinsic self-repairing effect on mechanical damage and electrical damage.

The invention discloses a high-strength and high-resilience TPE (thermoplastic elastomer) and a preparation method thereof in the technical field of high polymer materials, and the elastomer is prepared by taking a hydrogenated styrene block copolymer as a matrix and matching with a polyolefin rigid phase, plasticizing oil and a specific additive. The method is characterized in that two self-made reaction type modifiers are introduced, wherein one self-made reaction type modifier is a core-shell nano reinforcing agent containing an epoxy functional group and polyhedral oligomeric siloxane, and the other self-made reaction type modifier is a furan maleimide bifunctional dynamic cross-linking agent. The nano reinforcing agent is prepared through silane hydrolysis and amination reaction, and can react with a matrix for grafting, so that the strength and creep resistance of the material are remarkably improved; the dynamic cross-linking agent is synthesized through step-by-step isocyanate addition reaction, a cross-linked network can be reversibly formed in the processing process, and the material is endowed with extremely high rebound resilience and low permanent deformation. The obtained product has high strength, high resilience and excellent processability, and is especially suitable for high-end fitness equipment.

The invention relates to the field of organic chemistry, and particularly discloses a synthetic method of berberine hydrochloride. The synthesis method of berberine hydrochloride comprises the following steps: S1, carrying out reductive amination reaction on bromohomopiperony lamine and o-veratraldehyde to synthesize an intermediate II; s2, carrying out Suzuki coupling reaction on the intermediate II and an organic boron compound under the catalysis of a palladium metal organic matter to synthesize an intermediate III; s3, the intermediate III and organic chloride are subjected to an amino chlorination reaction, and an intermediate IV is synthesized; s4, carrying out intramolecular atom transfer radical addition and intramolecular Friedel-Crafts alkylation cascade reaction on the intermediate IV in a mixed solvent under the catalysis of a copper catalyst to synthesize an intermediate V; and S5, carrying out oxidative aromatization reaction on the intermediate V and iodine under the catalysis of alkali to synthesize berberine hydrochloride. The synthesis process is simpler, reaction conditions are easier to control, the yield is high, and the method is suitable for industrial production.

The invention belongs to the technical field of organic synthesis, and provides a preparation method of a cationic lipid compound, which comprises the following steps: (1) reacting 1, 5-dihalopentane, 2-tert-butyl glycolate and alkali to obtain a product G; (2) hydrolyzing the product G under an acidic condition to obtain a product H; (3) carrying out esterification reaction on the product H, the raw material C, 4-dimethylaminopyridine and a condensing agent in dichloromethane to obtain a product J; and (4) carrying out amination reaction on the product J, the raw material L and alkali in acetonitrile to obtain the cationic lipid compound. Compared with the prior art, the method has the relatively remarkable advantages that when the first part of halogenated long-chain alkyl ester H is synthesized by the method, 1, 5-dihalopentane and 2-tert-butyl glycolate are used as raw materials, the halogenated long-chain alkyl ester J is synthesized by a simple method, the product is obtained at a higher yield in synthesis, and the method is suitable for kilogram-level production. The route synthesis only comprises four steps of chemical reactions, and is suitable for industrial production.

The invention discloses a method for preparing 1, 3-propylene glycol by hydrating and hydrogenating acrolein, which comprises the following steps: carrying out hydration reaction by taking an acrolein aqueous solution as a raw material and taking acylated and aminated modified polystyrene resin as a catalyst; carrying out flash evaporation or gas stripping on the product after the reaction to remove acrolein, condensing and recovering the removed acrolein, and carrying out hydrogenation reaction on the acrolein-removed mixed solution serving as a hydrogenation raw material on a metal catalyst; and after the reaction is finished, performing flash evaporation on the product to remove water and light components, and performing vacuum rectification to obtain a high-purity 1, 3-propylene glycol product. According to the method, the modified resin is used for catalyzing the acrolein hydration reaction, the overall yield of the 1, 3-propylene glycol can be increased, the catalyst modification process is simple, the cost is low, the additional value of the final product is high, and the method is suitable for industrial production.

The invention relates to the technical field of batteries, in particular to a low-hydrogen-evolution graphene material for a lead-acid battery and a preparation method thereof.The method comprises the steps that firstly, ethidene diamine is grafted to the surface of graphene oxide through a carbodiimide / active ester method, and aminated graphene is obtained; performing heat treatment in a nitrogen / ammonia gas atmosphere to realize nitrogen doping; compounding with titanium dioxide, and carrying out hydrothermal reaction to form a stable structure; then, sequentially grafting imidazolium silane and perfluorodecyl silane to carry out hydrophobic modification; and finally, stabilization and low-temperature re-nitridation curing are carried out through titanium tetrabutoxide. The graphene material prepared by the method endows the battery with excellent performance, and is low in direct-current internal resistance and high in capacity retention ratio.

The pure membrane MBBR sewage treatment system comprises an anoxic denitrification zone, an anaerobic ammonia oxidation zone, an aerobic oxidation zone, a high-density sedimentation zone, an MBBR biological filtration zone, a backwashing water tank and an equipment room, the anoxic denitrification region is used for carrying out amination reaction, organic matter hydrolysis reaction and denitrification reaction on the sewage and nitrate and nitrite in the anoxic denitrification region; the anaerobic ammonia oxidation zone is used for reacting the sewage with nitrite to generate nitrogen; the aerobic oxidation zone is used for promoting microorganisms to degrade organic matters in sewage and convert ammonia nitrogen; the high-density settling zone is used for separating muddy water in sewage; the MBBR biological filtration area is used for filtering suspended matters in the sewage; the backwashing water tank is used for providing backwashing make-up water for the MBBR biological filtration area; and the equipment room is used for placing disinfection equipment, a fan and a power distribution control system.

The invention discloses preparation and application of a reductive amination catalyst. The preparation method of the catalyst comprises the following steps: step 1, preparing an SrTiO3 carrier; step 2, loading a nickel source into the prepared SrTiO3 carrier to form a nickel-loaded SrTiO3 catalyst precursor; and step 3, roasting the SrTiO3 catalyst precursor to obtain the SrTiO3 loaded nickel catalyst. Large-scale production of the non-noble metal catalyst is realized by adopting a co-precipitation method and an impregnation method which are simple in process and environment-friendly under the condition of room temperature, the obtained material can be used for reductive amination reaction of acetophenone under the condition of taking water as a solvent and shows excellent catalytic performance, and after 50 times of application, the acetophenone conversion rate is gt; the selectivity of alpha-phenylethylamine is gt; the selectivity of the alpha-phenethyl alcohol is 1t; and 2%.

The invention discloses a nano-enzyme-SERS (Surface Enhanced Raman Scattering) bifunctional sensor for detecting colorectal cancer markers with high sensitivity as well as a preparation method and application of the nano-enzyme-SERS bifunctional sensor. The preparation method comprises the following steps: coating a layer of platinum (Pt) on the surface of gold nanoparticles (AuNPs) by utilizing a chemical reduction method so as to form gold-platinum nanoparticles (Au (at) Pt NPs); assembling the synthesized Au (at) Pt NPs into an aminated capillary tube through electrostatic adsorption, so as to prepare a capillary tube SERS (Surface Enhanced Raman Scattering) substrate; the surface of Au (at) Pt NPs is modified with a marker aptamer through an Au-S bond, and the nano enzyme-SERS dual-function sensor is prepared. In the presence of hydrogen peroxide (H2O2), the Au (at) Pt NPs can catalyze the oxidation of 3, 3 ', 5, 5'-tetramethyl benzidine (TMB) to generate oxidized TMB (oxTMB) with a strong SERS (Surface Enhanced Raman Scattering) signal. When Hcy exists, the reductive sulfydryl of Hcy consumes hydroxyl free radicals (. OH) generated by H2O2 decomposition, so that TMB oxidation is inhibited, and SERS signal intensity is weakened. A linear regression equation of the logarithm of the Hcy concentration and the signal intensity is drawn according to the SERS signal intensity, so that quantitative detection of the Hcy is realized.

The invention discloses a high-wear-resistance supercritical foaming TPU material and a preparation method thereof, and relates to the technical field of high polymer materials, the material is prepared from the following components by weight: 100 parts of TPU particles, 5-20 parts of a wear-resistant filler, 3-10 parts of a compatilizer, 3-5 parts of a supercritical fluid foaming agent, 1-5 parts of a foaming promoter, 0.5-2 parts of an antioxidant and 0.5-2 parts of a lubricant; the wear-resistant filler is a compound of surface amination modified nano silicon dioxide and surface carboxylation modified polytetrafluoroethylene micro powder, the wear-resistant filler, TPU and other auxiliaries are subjected to melt blending granulation to obtain composite master batches, after the master batches are formed into sample strips, the sample strips are subjected to supercritical fluid impregnation and rapid pressure relief foaming, and the final product is obtained. Through a unique compound wear-resistant system and interface design, excellent wear resistance can still be maintained after supercritical foaming, the industrial problem that the wear resistance of a foaming material is poor is solved, the process is environment-friendly, and industrial production is easy.

The invention discloses a synthesis method of a mono / dibromo pyridine derivative, which comprises the following steps: reacting a pyridine derivative with dimethyl butynedioate and methyl pyruvate at room temperature by using acetonitrile as a solvent to generate a dearomatized heteroaromatic compound; in an oxygen environment, copper bromide is used for brominating the dearomatized heteroaromatic compound to realize dibromination, and if potassium carbonate is additionally added in the reaction, monobromination is realized; and finally, respectively generating mono / dibromopyridine derivatives under hydrochloric acid hydrolysis. A carbon halogen bond of bromopyridine has very high activity, and various reactions such as Suzuki coupling, Sonogashira coupling, Heck reaction, amination reaction and the like can be carried out. On the basis, the polysubstituted bromopyridine can be subjected to selective reaction, and many new ideas can be provided for organic synthesis. The method disclosed by the invention is simple and safe to operate and environment-friendly, the cost is lower by using the copper bromide, and the required reaction conditions are simple.

The invention provides a reductive amination catalyst as well as a preparation method and application thereof, and belongs to the field of catalysis. The invention provides a reductive amination catalyst. The reductive amination catalyst comprises layered Al2O3 and an alloy loaded on the surface of the layered Al2O3, the alloy comprises a nickel element and a non-noble metal element; the non-noble metal elements comprise one or more of Cu, Mg, Ca, Co and Zn. The nickel element and the selected non-noble metal element are alloyed to adjust the charge structure of a metal site, so that excessive hydrogenation of HMF is inhibited during catalysis, it is ensured that only the aldehyde group of HMF is subjected to a reductive amination reaction, and therefore the selectivity of HMFA is improved.

The application belongs to the technical field of medical preparations. The application provides a modified quantum dot Chlorella polyhedral composite material for radiotherapy sensitization, a preparation method and application. The preparation method comprises the following steps: preparing a doped tungsten-chromium gallate quantum dot with a chemical formula of Zn 0.98 Ga2O4:W 0.02 6+ ,Cr 0.02 3+ ; then, the doped tungsten-chromium gallate quantum dot is modified by amination, and then modified by a polysaccharide mixture composed of alpha-maltose, cellulose and sodium alginate; finally, the doped tungsten-chromium gallate quantum dot is co-incubated with Chlorella polyhedral to obtain the modified quantum dot Chlorella polyhedral composite material. The modified quantum dot can enter Chlorella polyhedral in a large amount, and the modified quantum dot in the material obtained by the application is not easy to overflow or fall off, and is easy to preserve, compared with the prior art. Meanwhile, the material obtained by the application has a very high killing effect on CT26 cells and A549 cells at a very low dose, and the cell apoptosis rates of the two kinds of cells are both more than 80%. Therefore, the application has a high industrial application prospect.

This utility model discloses a universal filter for amination reactions, belonging to the field of filter technology. The filter includes a tank, a cover, and a filter basket. A first pipe is connected to the tank, and a second pipe is connected to the cover. The filter basket divides the internal space of the tank into a first working space and a second working space. The filter basket includes an annular plate and a bottom plate, with a receiving container on the bottom plate. Liquid in the first working space enters the second working space after being filtered by the filter basket. The receiving container protrudes towards the second working space. This utility model, by providing a receiving container on the filter basket, facilitates the collection of some trapped particles, reduces particles retained on the filter basket, reduces the possibility of particles getting stuck in the filter holes, and reduces the frequency of the filter basket needing to be removed for cleaning. A baffle covers the receiving container, reducing the direct impact of the liquid flow on the internal cavity of the receiving container. The baffle and connecting rod are detachably connected, facilitating the collection of particles inside the receiving container.

This invention discloses a method for synthesizing a venetum intermediate, specifically as follows: Step 1: In an organic solvent, 2,4-difluorobenzoic acid and 5-hydroxy-7-azaindole undergo an etherification reaction under the action of an acid-binding agent. After the reaction, post-treatment yields 2-((1h-pyrrolo[2,3-b]pyridin-5-yl)oxy)-4-fluorobenzoic acid; Step 2: 2-((1h-pyrrolo[2,3-b]pyridin-5-yl)oxy)-4-fluorobenzoic acid reacts with 1-((2-(4-chlorophenyl)-4,4-dimethylcyclohexene-1-)methyl)piperazine in… An amination reaction occurs under the action of a base. After the reaction, post-treatment yields 2-(7-azaindole-5-oxy)-4-(4-((2-(4-chlorophenyl)-4,4-dimethylcyclohexene-1-)methyl)piperazine-1-)benzoic acid, i.e., Venetantora intermediate III. The synthetic process provided by this invention avoids Grignard reactions and subsequent hydrolysis reactions, shortens the operation steps, simplifies the synthetic process, and provides a simple and easy-to-operate synthetic process. The raw materials are inexpensive and readily available, while avoiding the use of highly toxic raw materials. The production process is green and environmentally friendly, and suitable for industrial production.

The invention provides a preparation method of high-conductivity composite graphene, conductive ink and application thereof, and the preparation method comprises the following steps: dispersing graphene into a solvent to obtain a graphene dispersion liquid; adding a silane coupling agent with an amino group into the graphene dispersion liquid, and reacting to obtain aminated graphene; and adding a first dispersing agent into the aminated graphene, adding silver powder after uniform dispersion, and grinding to form an Ag-N coordinate bond between the silver powder and the aminated graphene, thereby obtaining the high-conductivity composite graphene. In the preparation method of the high-conductivity composite graphene provided by the invention, a silane coupling agent with an amino group is added into a graphene dispersion liquid, amination modification is completed through a condensation reaction with a hydroxyl group on the surface of the graphene, silver powder and the amino group of the graphene form an Ag-N coordinate bond, so that silver particles are completely coated with the graphene, a continuous C-Ag-C conductive network is constructed, and the high-conductivity composite graphene is obtained. According to the network, path breakpoints are reduced, interface contact resistance is reduced, charge transmission efficiency is improved, conductivity reduction after graphene compounding is effectively inhibited, and high conductivity and high heat resistance are achieved.

The invention belongs to the technical field of synthesis of organic compounds, and particularly relates to a process for preparing fipronil and an intermediate thereof. Toxic 1, 2-dichloroethane is comprehensively replaced by bio-based gamma-valerolactone, low-toxicity cyclopentyl methyl ether is matched, and N, N-dimethylformamide necessary for the process is recycled, so that consumption is greatly reduced; the continuous processes of amination, diazotization and the like are realized through a tubular reactor, a micro-reactor and a static mixer, and separation technologies such as pervaporation membrane and vacuum distillation are combined, so that the reaction time is shortened, the solvent recovery rate is increased, and the production is promoted to be continuously transformed to green. The supported FeCl3 / SiO2-NH2 catalyst disclosed by the invention can be repeatedly used, and byproducts and tail gas can be recycled and reused. In addition, diazonium salt residues are controlled to be smaller than or equal to 0.5% through near infrared spectroscopy, citric acid is subjected to stable oxidation reaction, a purification process is combined, it is ensured that the finished product is high in purity, excellent in yield and small in batch fluctuation, and efficiency and safety are both considered.

A process for producing amines by reductive amination, the process includes introducing a feed stream, the feed stream comprising an amino alcohol and a reducing agent, and hydrogen in a reaction zone of a reactor, and contacting the feed stream with a catalyst in the reaction zone. A hydrogen flow rate into the reaction zone is adjusted, and a product stream comprising ethyleneamines is extracted. The catalyst includes a carrier component selected from alumina, silica, and combinations thereof; and an active component having a first metal, a second metal, and a third metal. The first metal is selected from cobalt, nickel, and copper, the second metal is selected from rhenium, ruthenium, chromium, zinc, sodium, calcium, magnesium, strontium, lithium, potassium, barium, cesium, lanthanum, tungsten, iron, silver, titanium, manganese, aluminum, rhodium, platinum, palladium, iridium, and combinations thereof, and the third metal is niobium.

The invention belongs to the technical field of tumor treatment, and particularly relates to a metal polyphenol network coated drug-loaded mesoporous organic silicon nanoparticle and a preparation method and application thereof.The mesoporous organic silicon nanoparticle (MON) is prepared through a micelle / precursor co-template assembly method, then amination modification, carboxylation modification and drug co-loading are further conducted on the mesoporous organic silicon nanoparticle (MON), and the metal polyphenol network coated drug-loaded mesoporous organic silicon nanoparticle is obtained. The DQMCTH nano-particles are prepared through the steps that DQMCTH nano-particles are taken as a raw material, a copper salt solution and a tannic acid (TA) solution are added and mixed, then a coordination complexation reaction is conducted, hyaluronic acid (HA) is added for modification, and the DQMCTH nano-particles obtained through the method are in a sphere-like shape, regular in shape, uniform in distribution and free of obvious dendritic branches and central radial pore channels. The polypeptide is effectively protected by MPN and is subjected to HA targeted modification; more importantly, the DQMCTH nanoparticles prepared by the method disclosed by the invention show pH / GSH / HAase triple sensitive drug release, and cell and animal experiment results show that the DQMCTH nanoparticles prepared by the method disclosed by the invention have relatively high anti-tumor activity on a drug-resistant breast cancer model.

The invention discloses a high-temperature-resistant low-friction-coefficient low-abrasion sealing material and a preparation method thereof, and belongs to the technical field of sealing materials. The sealing material is prepared from the following raw materials in parts by mass: 60 to 80 parts of hydrogenated butadiene-acrylonitrile rubber, 20 to 40 parts of hydrogenated carboxyl butadiene-acrylonitrile rubber, 40 to 50 parts of carbon black N234, 4 to 6 parts of modified carbon fiber, 2 to 4 parts of modified hexagonal boron nitride, 3 to 5 parts of liquid polybutadiene, 3 to 4 parts of composite vulcanizing agent, 2 to 3 parts of zinc oxide, 1 to 2 parts of rubber anti-aging agent 445, 1 to 2 parts of anti-aging agent MB, 0.2 to 0.5 part of accelerant BZ and 0.5 to 2 parts of stearic acid. The modified carbon fiber is obtained by growing molybdenum disulfide on the surface of carbon fiber in situ and performing amination modification, the modified hexagonal boron nitride is obtained by performing grafting reaction on hydroxylated hexagonal boron nitride and an epoxy silane coupling agent, and the sealing material provided by the invention has high wear resistance and high temperature resistance.

The invention relates to the field of packaging bags, and discloses an antibacterial composite bag for food and a preparation method thereof, the antibacterial composite bag for food comprises low density polyethylene, a functional additive, modified tetrapod-like zinc oxide whiskers and a lubricant; according to the functional additive, lignin nanoparticles are used as a core, polydopamine is used as a shell, graphene oxide is assembled to prepare a composite material, and gamma-aminopropyltriethoxysilane is used for amination grafting of the composite material. The nano cuprous oxide is loaded on the aminated composite material by adopting a one-step reduction method and reacts with glycidyl dodecyl dimethyl ammonium chloride; the modified tetrapod-like zinc oxide whisker is prepared by coating the surface of the tetrapod-like zinc oxide whisker with silver-doped zinc oxide through a hydrothermal synthesis method, and by adding the functional additive and the modified tetrapod-like zinc oxide whisker, the matrix material is endowed with good mechanical property, antibacterial property, ultraviolet resistance, heat resistance and flame retardance.

The invention relates to a high-wear-resistance floor coating based on TiC hybrid resin and a preparation process of the high-wear-resistance floor coating, and belongs to the technical field of floor coatings. The high-wear-resistance floor coating is prepared from a component A and a component B in parts by weight, wherein the component A is prepared from 90 to 100 parts of modified waterborne epoxy resin emulsion; the component B comprises the following components in parts by weight: 20-30 parts of modified fibrous wollastonite, 0.5-1.5 parts of a flatting agent, 0.5-1 part of a defoaming agent, 1-2 parts of a wetting dispersant, 30-45 parts of a water-based amine curing agent and 20-40 parts of water; the weight ratio of the component A to the component B is 1: (0.75-0.85); titanium carbide subjected to amination and surface grafting polycaprolactone treatment is added into the coating, so that the wear resistance of the floor coating can be improved.

The application provides a high-efficiency catalyst for cyclic carbonates, a preparation method and application thereof, and compared with the prior art, the catalyst is prepared from a monoamine-based polyether, a polyamine, a phenolic monomer and formaldehyde, an aminated intermediate is synthesized through a chemical grafting reaction, and then is reacted with an epoxy group quaternary ammonium salt to obtain a supported quaternary ammonium salt catalyst. The catalyst molecular structure comprises a quaternary ammonium salt group, a tertiary amine group, a hydroxyl group and an ether bond structure, can not only play a catalytic effect of the quaternary ammonium salt, but also has a certain complexing effect of oxygen atoms in the tertiary amine group, the hydroxyl group and the ether bond structure, can stabilize the ion pair of the quaternary ammonium salt catalyst, and ensure the catalytic effect of the catalyst. Moreover, the catalyst prepared in the application can be independently used for catalyzing preparation of cyclic carbonates, does not need a cocatalyst, and has high catalytic efficiency and good stability.

The application provides a kind of zinc oxide nanoparticles / quaternary amine modified polystyrene nanospheres and its preparation method and application.The application prepares carboxyl functionalized PS / PVP nanospheres with high monodispersity by environmentally friendly water dispersion polymerization method;ZnONPs are successfully loaded after complexing zinc ions with the surface PVP pyrrolidone ring of PS / PVP nanospheres and reducing with reducing agent, and the surface of nanospheres is modified with quaternary amine groups by amidation and further quaternary amination of the surface carboxyl groups of PS / PVP nanospheres.The preparation method is simple, and the reaction condition is easy to realize.The material obtained by the method of the application is polystyrene nanosphere surface loaded with zinc oxide nanoparticles and grafted with quaternary amine groups;it is applied to antibacterial, and zinc oxide nanoparticles and quaternary amine groups play a synergistic effect, so that the material shows high antibacterial activity and can effectively inhibit the proliferation of escherichia coli and staphylococcus aureus.

This application relates to a terphenylamine skeleton compound, its preparation method, and its application, belonging to the field of chemical synthesis technology. The preparation method of the terphenylamine skeleton compound of this application includes the following steps: dissolving 2,4,6-triphenylaniline with thiazole-4-carboxaldehyde or thiophene-3-carboxaldehyde in a solvent, conducting a reductive amination reaction under reducing agent conditions, quenching, extraction, washing, concentration to remove solvent, and purification to obtain the terphenylamine skeleton compound. This application provides a simple and mild synthetic method for the natural active products 5'-phenyl-N-(thiazol-4-ylmethyl)-[1,1':3',1''-terphenyl]-2'-amine and 5'-phenyl-N-(thiophene-3-ylmethyl)-[1,1':3',1''-terphenyl]-2'-amine, which can only be extracted from the secondary metabolites of the marine fungus Aspergillus sp. Furthermore, this method utilizes widely available raw materials, which is beneficial for large-scale industrial production of these natural active products.

The present invention provides a process for preparing namodenoson. More specifically, the present disclosure provides a simple and high yield process for Good Manufacturing Practice of namodenoson. The process involves the steps of protection, oxidation, chlorination, amination, reaction and final deprotection.

The subject of the invention is N-substituted derivatives of l-(l-phenyl-3-aryl)-lH-pyrazol-4-yl)methanamine with the general formula 1, where ¥ represents CH or N, R1 represents hydrogen, R2 represents no substituent, R3 represents hydrogen, while R4 represents N-propylbenzamide, benzo[b]furan, dihydrobenzo [b] furan, methylenedioxybenzene, ethyl benzoate, or propyl benzoate, substituted accordingly, their method of production and application, and the method of obtaining and application of N-substituted derivatives of l-(l-phenyl-3-aryl)-IH-pyrazol-4-yl)methanamine with the general formula 1, where Y represents C, CH, or N, R1 represents hydrogen or a methyl group, R2 represents a methyl group or no substituent, R3 represents hydrogen or a methyl group, while R4 represents dimethylpyrazole, methylpyrazole, dimethylimidazo[l,2-a]pyrimidine, or isopropoxybenzene, substituted accordingly. The compounds that are the subject of the invention are obtained through reductive amination using borohydride derivatives as the reducing agent, advantageously sodium triacetoxyborohydride, in the amount of 1.4-2.0 eq, amine in the amount of 1.0-1.1 eq, advantageously in slight excess, base, advantageously triethylamine in the amount of 1.0-1.1 eq (in the case of using amine in the form of hydrochloride), and the starting aldehyde. The reaction is conducted in a nonpolar solvent environment, advantageously dichloroethane at a concentration of about 0.1 M. The crude product is purified by column chromatography on silica gel using a methanol in dichloromethane mixture as the eluent, in concentration ranges from 2% to 5%. In order to obtain a solid form and improve the physicochemical parameters, the free bases are converted into hydrochloride form, and then crystallized from a polar solvent, advantageously ethanol or propanol.

The present invention provides a cationic electrodeposition coating composition with a rust prevention property enhanced by improving the adhesion and the blocking property of a coating film obtained from a cationic electrodeposition coating composition as compared with conventional ones. The present invention provides a cationic electrodeposition coating composition including an aminated epoxy resin and a blocked polyisocyanate curing agent, wherein the aminated epoxy resin is an aminated epoxy resin obtained by reacting an amine compound with an epoxy resin, the aminated epoxy resin has a molecular weight distribution of 2.7 or less, and a rate of elongation of an electrodeposition coating film formed by applying the cationic electrodeposition coating composition to a steel sheet such that a cured film thickness is 20 μm, followed by baking at 160° C. for 15 minutes, is 0.1 to 4.5%.

The application discloses a kind of gallium indium selective separation adsorbents and preparation method thereof, belong to functional metallurgical polymer adsorption material technical field.Gallium, indium physical and chemical properties are extremely similar, conventional separation process is extremely difficult, current industrial separation completely relies on organic extraction process, there is long process, organic reagent cost is high, organic waste water pollution is serious, separation precision is low defect;Conventional commercial adsorption resin is poor to gallium, indium selectivity, separation coefficient is extremely low, cannot realize industrialization high-efficiency separation.The application is with macroporous polystyrene resin as matrix, by nitration, reduction, amination, chelation functional group grafting multi-step modification process, and high selectivity gallium indium separation special adsorbent is prepared.The adsorbent can preferentially specific adsorption of gallium ions in acidic system, and indium ions remain in solution, and the separation coefficient of gallium and indium is greater than or equal to 20, which can completely replace traditional extraction separation process, realize extraction-free, green, high-precision, low-cost gallium and indium high-efficiency separation, fill the industry extraction-free gallium and indium industrialization separation material technical blank.