3568 results about "Amination" patented technology

The invention discloses a magnetic acrylic acid series strongly basic anion exchange microballoon resin and a preparation method thereof. The microballoon resin has the following structure: the resin skeleton is internally provided with magnetic particles, wherein A stands for a radical containing quaternary ammonium salt. The preparation method comprises the following steps: acrylic acid series substances serve as a monomer, the monomer is mixed with cross-linking agent and pore-forming agent to form oil phase; the oil phase is uniformly mixed with the magnetic particles and then suspension polymerization is carried out on the mixture; after going through amination and alkylation reaction, the polymerized magnetic polymer particles form the quaternary ammonium salt, namely the magnetic acrylic acid series strongly basic anion exchange microballoon resin. Exchange capacity of the resin is higher than any magnetic acrylic acid series strongly basic anion exchange microballoon resin ever found in existing literatures and reports and domestic market as well as foreign markets and can replace the traditional strongly basic anion exchange resin, thus being capable of being used for separating and removing soluble organisms in various water bodies, especially disinfection by-product precursor and multiple negative ions such as nitrate and phosphate.

A series of ultrahigh-cross-linked weakly alkaline-anionic exchange resin with both adsorption and exchange functions, which has different specific surface areas and exchange capacities, is prepared from low-cross-linked macroporous polystyrene through chloromethylation, cross-linking reaction, where the nitrobenzene or substituted nitrobenzene is used as solvent and the Lewis acid is used as catalyst, and amination by dimethylamine.

The invention discloses polyimide foam and a preparation method thereof. Aromatic dianhydride and/or aromatic acid ester, alcohol with low molecular, a catalyst and a surface active agent are mixed proportionally in a polar solvent and react so as to form foam precursor solution. The foam precursor solution and isocyanate react in a mould and freely foam into a foam intermediate. The intermediate is solidified by microwave radiation or/and oven heating to obtain solid polyimide foam. The preparation process has short path, simple technology, good stability for storage of the foam precursor solution, adaptation to processing technologies of pouring, spray coating, extrusion, and the like, no occurrence of defects of cracked foam, foam combination, subsidence and incomplete amination, low preparation cost as well as uniform hold diameter and stable performance of the solid polyimide form, and is convenient for popularization and application.

The invention provides a method for preparing ethylenediamine from reactants of glycol and ammonia in the presence of a solid catalyst with a main component of copper through a hydrogenation and amination one-step method. The method comprises the following steps of: making glycol containing water or not containing water and ammonia enter a reactor filled with the catalyst with a main component of copper, performing dehydrogenation to obtain the ethylenediamine and water and an ethanolamine byproduct, and separating the mixture obtained through reaction to obtain the product of ethylenediamine.

The invention provides a solid catalyst for preparing ethylene diamine through catalytic amination of ethylene glycol. The catalyst takes copper and nickel as main components and zirconium as an auxiliary component; and other metal components can be one or more than one of zinc, aluminum, titanium, manganese and cerium. The invention further provides a preparation method of the solid catalyst. The preparation method is characterized in that the catalyst is prepared through the processes of roasting, reducing and re-roasting by utilizing a coprecipitation method.

The invention belongs to the technical field of friction material, and in particular relates to a graphene-nano polytetrafluoroethylene composite filler with a function of reducing friction, as well as a preparation method and the application of the composite filler. The composite filler comprises the following main components in parts by weight: 1 part of modified graphene and 1-20 parts of modified nano polytetrafluoroethylene; the preparation method of the composite filler comprises the following steps: separately reacting graphene and nano polytetrafluoroethylene with amination reagent and carboxylation reagent to obtain the modified graphene and the modified nano polytetrafluoroethylene; carrying condensation reaction so that the modified graphene and the modified nano polytetrafluoroethylene are connected with each other by a covalent bond to obtain the graphene-nano polytetrafluoroethylene composite filler. The function of friction reduction of the graphene and the function of lubrication of the nano polytetrafluoroethylene are utilized at the same time; after the composite filler is added to a polymer material, the friction coefficient and the wear rate of the material can be reduced, and the mechanical property of the material can be improved.

Optical glasses and polymers are described that incorporate homogeneously dispersed fullerene molecules. The resultant materials may be used as optical filters, the cut-off frequency being easily adjustable by changing the fullerene content. To prepare glasses fullerene molecules are firstly functionalized by amination prior to being incorporated into a sol-gel process to prepare the glass. To prepare polymers a pre-existing polymer may be subject to fullerenation, or fullerene may be copolymerized with a selected monomer.

The invention relates to a dual emission rate type fluorescent probe for visually detecting carbon dots-Au nanoclusters of mercury ions and a preparation method. Dual-emission composite silicon dioxide nanoparticles are composite silicon dioxide nanoparticles formed by utilizing carbon dot covered silicon dioxide particles as cores and covalently coupling the surfaces of the carbon dot covered silicon dioxide particles with the Au nanoclusters after surface amination. The carbon dots located in the silicon dioxide nanoparticle cores are taken as reference fluorescence signals, the Au nanoclusters on the outer layers are taken as response fluorescence signals, and the signals are used for Hg<2+> selective recognition. The Au nanoclusters as the response fluorescence signals are connected to the surface of a silicon layer through covalent bond connection, and one stable nano-fluorescent probe is formed. When the dual-fluorescence composite nanoparticles are taken as the rate type fluorescent probes, the intensity of the carbon dot fluorescence signals in the cores basically keep unchanged, and the Au nanoclusters on the outer layers can be bonded with Hg<2+> selectively so as to result in fluorescence quenching of the Au nanoclusters on the outer layers.

The invention relates to a preparation method of an aminated nanofiber membrane with a high specific surface area. The preparation method comprises the following steps of: dissolving two polymer materials with the weight ratio of 1: (0.1-10) or dissolving a polymer material and an inorganic salt into a solvent, dissolving while stirring at the temperature of 20-80 DEG C for 4-96h, and carrying out electrostatic spinning to obtain a composite nanofiber membrane; soaking the composite nanofiber membrane into water, regulating the pH value, soaking at the temperature of 20-95 DEG C for 2-48h, washing and drying to obtain a nanofiber membrane with a porous micro/nano structure and a high specific surface area; and immersing the nanofiber membrane with a porous micro/nano structure and a high specific surface area into water, adding an amination reaction reagent to carry out amination reaction at the temperature of 50-200 DEG C, then, taking out the fiber membrane, washing the fiber membrane to be neutral, and drying the fiber membrane to obtain the aminated nanofiber membrane with a high specific surface area. The product provided by the invention is applied to fields such as adsorption and separation of precious metal ions, heavy metal ions and transition metal ions, chemical probes, sensors, environment monitoring, catalysts, biological medicines and the like.

Synthesis of a chemical compound having the formula A-B-C that may serve for applications such as drug delivery where A is a chemiluminescent, moiety, B is a photochromic moiety, and C is a biologically active moiety where A-B-C may serve as a prodrug. Novel synthetic methods of the present invention to form the prodrug comprised the steps of (1) forming a benzophenone, (2) forming a diaryl ethylene, (3) attaching a phthalimide moiety to at least one of the aryl groups of the ethylene to form a phthalimide-ethylene conjugate, (4) condensing two ethylene-phthalimide conjugates to form a phthalimide-pentadiene conjugate, (5) converting the phthalimide to the phthalhydrazide by reaction with hydrazine to form a carrier compound according to the present invention, and (6) reacting the carrier compound with an nucleophilic moiety of the drug to form the corresponding prodrug. Alternatively the carrier can be prepared by using the halo-substituted diaryl ethylene to make the corresponding cationic leuco dye-like compound with known methods. The cationic compound then is protected by reacting with a nucleophile and coupled with the aminophathalimide by palladium-catalyzed amination to form the protected phthalimide-pentadiene conjugate. The latter is refluxed with hydrazine to convert its phthalimide to the phthalhydrazide and acidified to give the carrier. An additional aspect of the present invention relates to the use of these compounds as antiviral agents for the treatment of viral infections such as HIV and as anticancer agents for the treatment of cancers such as bowel, lung, and breast cancer.

A method of chemically-grafting graphene oxide onto surface of carbon fibers. The invention relates to a surface modification method of the carbon fibers and aims to solve the problems of high surface inertia, low surface energy and poor mechanical and thermal performances of the carbon fibers in the prior art. The method includes following steps: (1) preparing graphene oxide through improved Hummer's method; (2) oxidizing the carbon fibers; (3) performing surface modification amination treatment to the carbon fibers; and (4) chemically-grafting the graphene oxide onto the surface of the carbon fibers. The surface of the carbon fibers is improved significantly in wettability and adhesivity and is significantly improved in roughness after grafting, so that the strength and toughness of the carbon fiber are significantly improved, wherein the strength is increased by 20-25% than carbon fiber raw filament and the toughness is increased by 35-40% that the carbon fiber raw filament. The method is used for surface modification of the carbon fibers.

Methods of preparing kinase inhibiting pharmaceutical compounds having the formula (I):

or a pharmaceutically acceptable salt or solvate thereof, wherein R₁ through R₆ and Z are as described in the specification. The methods according to the invention utilize an amination process, in which a pyrrole is reacted with a haloamine, preferably chloramine. This step is followed by cyclization to form the pyrrolotriazine core.

The present invention provides catalyst compositions useful for transamination reactions. The catalyst compositions have a catalyst support that includes transitional alumina, use a low metal loading (for example, less than 25 wt. %), and do not require the presence of rhenium. The catalyst compositions are able to advantageously promote transamination of a reactant product (such as the transamination of EDA to DETA) with excellent activity and selectivity, and similar to transaminations promoted using a precious metal-containing catalyst.

The invention relates to a preparation method and application of a magnetic silicon dioxide composite microsphere. Superparamagnetic ferroferric oxide nano particles of which the diameter ranges from 4 nm to 30 nm are prepared through a high-temperature pyrolysis method, a silicon dioxide shell of which the thickness ranges from 5 nm to 20nm covers the outer surfaces of the magnetic ferroferric oxide nano particles through a reverse microemulsion method, amination modification is conducted on the silicon dioxide surface, glutaraldehyde is used as a crosslinking arm, ligand protein is connected into, and protein separation is conducted through specific binding of ligand protein and target protein. The prepared magnetic microsphere is small in particle diameter and good in monodispersity, the composite microsphere with amine is large in specific surface area, nucleophilic addition is utilized, after the crosslinking arm glutaraldehyde is connected into, multiple kinds of ligand protein can be connected into, and then multiple kinds of target protein can be separated. The method is suitable for rapid separation and application of protein in biological samples, and has wide application prospect and great application value in the biomedical field and other fields.

Provided herein are catalysts useful in reductive amination, which include nickel, copper, zirconium and/or chromium, oxygen, and tin. The presence of the tin increases the selectivity of the catalyst in reductive aminations over the catalysts of the prior art.

The invention aims at acid, alkali and heat labile features of sinomenine molecular structure, and provides an innovative structural reconstruction idea for new chemical synthesis of ring A, ring C, and ring D sinomenine derivatives. The chemical synthetic method includes amination and acylation of 1-position, C-C or C-O connection of 1 position, dicarbonylation and six-membered N heterocyclization of 3-position and 4-position, two molecule sinomenine adduction of connection of 4-hydroxyl and 1-amino, amination and acylation of 6-position, simultaneous amination and x-membered N heterocyclization of 6-position and 7-position, and opening of D ring and terminal amino group modification thereof. The method is novel and unique. The sinomenine derivatives have good antiinflammation activity and bioactivity evaluated by synovial membrane tumor cell (SW982), and can be used in drug and health products for resisting rheumatoid arthritis.

The invention discloses a porous carbon microsphere with the surface covered with graphene, and a preparing method and application of the porous carbon microsphere. The polymer porous microsphere with the surface provided with the amination perssad serves as a template, the polymer microsphere is fully soaked in a sulfonation graphene water solution and dried, the sulfonation graphene and the polymer microsphere are combined, the polymer porous microsphere with the surface covered with sulfonation graphene is obtained and is carbonized at a high temperature in the protective atmosphere, and a target product, namely the porous carbon microsphere with the surface covered with graphene is obtained. The diameter of the target product is in the controllable range of 5 nm to 1,000 microns, a porous structure is achieved, the aperture is in the controllable range of 5 nm to 100 nm, a very large specific area is achieved, a very high electron transfer rate and good electrical conductivity are presented, the porous carbon microsphere can be widely applied to many fields such as catalyst loads, lithium ion batteries, supercapacitors, adsorption, sea water desalination and sensing, the preparing technology is simple, controllability of the reaction process is high, and industrial large-scale production is facilitated.