70 results about "Phthalimides" patented technology

The invention relates to the technical field of pesticide synthesis, and discloses a synthesis method of captan. The preparation method comprises the following steps: respectively dropwise adding an aqueous solution of an alkali metal compound and perchloromethyl mercaptan into an aqueous solution of 1, 2, 3, 6-tetrahydrophthalimide, and controlling the pH value of a reaction system to be 7-11 in the dropwise adding process; and reacting after dropwise adding to obtain captan. According to the method, the alkali metal compound aqueous solution and the perchloromethyl mercaptan are dropwise added, and the pH value of a reaction system is controlled within a specific range in the dropwise adding process, so that decomposition of 1, 2, 3, 6-tetrahydrophthalimide and perchloromethyl mercaptan in an alkaline environment can be effectively avoided, the occurrence of series side reaction can be effectively reduced, and the yield of 1, 2, 3, 6-tetrahydrophthalimide and perchloromethyl mercaptan is improved. The utilization rate of the raw materials and the product yield are improved under the condition of not using a catalyst.

Disclosed is a method for preparing oxetan-2-ylmethanamine, which belongs to the field of organic synthesis. [2-(1-ethoxyethoxy)methyl]propylene oxide is used as an initial raw material, and reacted in the presence of potassium tert-butoxide and trimethylsulfoxonium iodide; the resulting product is reacted with a sulfonyl compound and triethylamine; the resulting product is reacted with a compound of phthalimide; the resulting product is reacted with an amino group-containing compound, to obtain oxetan-2-ylmethanamine. The method according to the disclosure allows for an overall yield of not less than 30% in scale-up production (kilogram level), which is higher. Moreover, compared with the traditional method for preparing oxetan-2-ylmethanamine, a palladium-carbon catalytic hydrogenation step is not required, and dangerous chemical-sodium azide is not required in the method according to the disclosure. Thus, the method has high safety, low production cost, simple operations, and thereby is suitable for industrial production.

This invention provides a method for preparing a foamed copper-based composite organic compound layer catalytic material, comprising the following steps: forming 8-hydroxyquinoline molybdenum (Mo(C)) on the surface of a foamed copper matrix. 9 H 6 NO) 4 Organic compound layer; 8-hydroxyquinoline molybdenum (Mo(C)) 9 H 6 NO) 4 The organic compound layer is converted into phthalimide 8-hydroxyquinoline molybdenum (C). 8 H 4 NO 2 ) 2 (C 9 H 6 NO) 2 ; Phthalimide 8-hydroxyquinoline molybdenum Mo(C) 8 H 4 NO 2 ) 2 (C 9 H 6 NO) 2 Conversion to copper phthalimide / 8-hydroxyquinoline molybdenum Cu(C) 8 H 4 NO 2 ) 2 / Mo(C 9 H 6 NO) 2 The foamed copper-based composite organic compound layer catalytic material is finally obtained. The catalytic material prepared by the method of this invention can effectively improve the Faradaic efficiency, ammonia selectivity, production rate, and nitrate removal rate of the electrochemical reduction of nitrate to ammonia technology.

The present application relates to the technical fields of UV coating, and discloses an environment-friendly UV curing coating for thin film aluminum plating process and a preparation method thereof, the present application uses polyethylene glycol diglycidyl ether, N-(4-carboxyl phenyl) phthalimide and acryloyl chloride as raw materials to prepare acrylate phthalimide polyethylene glycol containing two alkenyl groups, which is used as an active diluent to carry out a photocuring reaction with epoxy acrylate, contains a flexible polyether molecular chain, is crosslinked and solidified into an epoxy resin, has a good toughening effect, and improves the flexibility, impact resistance and bending strength of the coating. Moreover, the phthalimide structure has thermal stability, so that the coating has a good thermal decomposition temperature and heat resistance. The aluminum sheet is used as a base material, the coating has good adhesion and bonding properties, and has good practical application in the thin film aluminum plating process.

The present invention relates to an N-benzyl phthalimide derivative compound of formula I, a pharmaceutical composition comprising the same, a medicament, its use, combination, and methods for treating acute and chronic pain, primarily focusing on neuropathic disorders and syndromes associated with neuropathic pain.

The invention relates to the technical field of oral care compositions, in particular to an oral care composition and a preparation method and application thereof.The oral care composition comprises a first composition and a second composition, the first composition comprises an anti-sensitive agent, a cosolvent, a first thickening agent, a surfactant and a first auxiliary, and the second composition comprises an anti-sensitive agent, a cosolvent, a second thickening agent, a surfactant and a second auxiliary; the first composition comprises phthalimide peroxyhexanoic acid, a cosolvent, a first thickening agent, a first auxiliary agent and deionized water, the second composition comprises phthalimide peroxyhexanoic acid, a cosolvent, a second thickening agent, a second auxiliary agent and deionized water, at least one of the cosolvent, the first auxiliary agent and the second auxiliary agent contains a flavoring agent, and the first composition and the second composition are separately stored before use. The anti-sensitive agent is prevented from being in contact with the phthalimide peroxyhexanoic acid before use. According to the invention, the first composition and the second composition are respectively and independently stored, so that natural decomposition and activity attenuation of phthalimide peroxycaproic acid in the shelf life of the product are inhibited, and the product is ensured to retain high effective active oxygen content after being stored for a long time.

The application belongs to the field of organic synthesis chemistry and relates to a method for preparing alkyl-substituted glycine derivatives by using a visible light-driven decarboxylation alkylation reaction. The method comprises the following steps: mixing glycine derivatives, N-hydroxyphthalimide (NHPI) ester, 2D-COF-4 and an organic solvent, reacting under a blue LED lamp for 24 hours in an argon environment, and obtaining alkyl-substituted glycine derivatives. The method avoids the use of noble metal photocatalysts, the heterogeneous photosensitizer in the reaction is easy to recycle and reuse, the scope of the substrate is wide, and the functional group compatibility is good; the method can be successfully applied to a kilogram-scale amplification experiment, has a good industrial application prospect, and uses a green solvent, ethanol, which is conducive to reducing production cost and production risk and meets the requirements of developing green and environment-friendly chemistry.

The application discloses a synthesis method of 3,3-difluorocyclopentylamine hydrochloride, and particularly relates to the technical field of chemical synthesis. The synthesis method comprises the following steps: taking 2-cyclopentenone and phthalimide as raw materials, and sequentially performing a Michael addition reaction, deoxygenation fluorination, removal of a phthaloyl protecting group, Boc protection and deprotection and salt formation reaction to obtain 3,3-difluorocyclopentylamine hydrochloride. The synthesis route and process design of the application are reasonable, the starting raw material is 2-cyclopentenone, the required reaction condition is mild, the post-treatment method is simple, the operability is strong, the raw material and reagent are cheap and easy to obtain, and the total yield can reach 43.6%, so the synthesis method has large-scale preparation value.

The present invention relates to an insecticidal composition comprising of N-(phenylthio) phthalimide (NPP), neem oil and chitosan and method of preparation thereof. The composition of the present invention is useful against insects selected from Helicoverpa armigera, Mythimna separata, Spodoptera frugiperda and other Lepidopteran species of insects. The composition can serve as a formulation that possesses a lower probability of acquiring resistance.

The invention discloses a synthesis method of 9, 9-bis (trifluoromethyl)-2, 3, 6, 7-xanthene tetracarboxylic dianhydride, which comprises the following steps: (1) carrying out condensation reaction on N-methyl-4-nitrophthalimide and hexafluoroacetone trihydrate under the catalysis of trifluoromethanesulfonic acid to obtain a first intermediate; (2) performing catalytic etherification reaction on the first intermediate in the presence of sodium nitrite to obtain a second intermediate; (3) carrying out hydrolysis reaction on the second intermediate under an alkaline condition to obtain a third intermediate; and (4) dehydrating the third intermediate into anhydride to obtain 9, 9-bis (trifluoromethyl)-2, 3, 6, 7-xanthene tetracarboxylic dianhydride. According to the method, raw materials are low in price and easy to obtain, the reaction yield and the product purity are high, particularly, the situation that potassium permanganate oxidation or nitric acid oxidation is insufficient in the prior art is avoided, and the method is higher in safety, more environmentally friendly and suitable for large-scale industrial production.

The present invention provides A silsesquioxane of formula: (R1SiO1,5)x (R2SiO1,5)y, wherein x ≥ 2, y ≥ 2, and x + y = 6,8,10 or 12; R1 is L1-phthalimide, wherein L1 is a residue selected from the group consisting of saturated or unsaturated C2-C8 hydrocarbon radicals which may be straight, branched or cyclic; and the phthalimide is optionally substituted by one or more halogen, C1-C6 alkyl, -COOH, -OH or -NO2; and R2 is a residue selected from the group consisting of saturated or unsaturated C1-C8 hydrocarbon radicals, which may be straight, branched or cyclic, phenyl and vinyl; wherein the hydrocarbon radicals, phenyl and vinyl are optionally substituted by one or more halogens.

The application provides a synthesis method of N-substituted phthalimide compounds and relates to the technical field of organic synthesis. The synthesis method comprises the following steps: under the condition of having or not having a solvent, using a copper salt as a catalyst and a peroxide as an additive, synthesizing N-substituted phthalimide compounds by reacting phthalic acid compounds I with amide compounds II; the reaction raw materials of the synthesis method are cheap and easy to obtain, are safe and environmentally friendly, have good tolerance and resistance to various substituents and functional groups, are beneficial to large-scale industrial production, and provide an efficient, convenient, green, environmentally-friendly and low-cost synthesis path for N-substituted phthalimide compounds.

The application provides a preparation method of a UiO-66-NH2-based mixed matrix membrane, which comprises the following steps: 3,3',4,4'-diphenyltetracarboxylic dianhydride is prepared by adding 4-chloro-N-methyl phthalimide, a catalyst A, a reducing agent and an additive into an aprotic solvent; then UiO-66-NH2 is added into the reaction system to obtain anhydride-capped UiO-66-NH2 (BPDA); UiO-66-NH2 (BPDA), BPDA and ODA are added into DMAC, a dehydrating agent and a catalyst B are added to obtain BPDA-ODA type polyimide containing UiO-66-NH2; and the BPDA-ODA type polyimide containing UiO-66-NH2 and DMAC are configured into a casting solution to obtain a mixed matrix membrane UiO-66-NH2 / BPDA-ODA-N. Compared with the traditional direct doping method for preparing the mixed matrix membrane, the preparation method greatly improves the doping amount of UiO-66-NH2, which makes the permeation flux of CO2 further improved while the selectivity of retaining CO2 is reserved, and the CO2 separation performance is more excellent.

The invention discloses a preparation method of L-2, 4-diaminobutyric acid dihydrochloride, which comprises the following steps: (1) taking L-homoserine as an initial raw material, and reacting with concentrated hydrochloric acid in the presence of a zinc chloride / ferrous chloride synergistic catalyst to prepare L-2-amino-4-chlorobutyric acid hydrochloride; (2) after neutralization, carrying out an acylation reaction with ethyl chloroformate to generate N-ethoxycarbonyl-L-4-chlorobutyric acid; (3) carrying out esterification with ethanol so as to obtain N-ethoxycarbonyl-L-4-chlorobutyl amino acid ethyl ester; (4) under the catalysis of sodium iodide, carrying out nucleophilic substitution reaction with phthalimide potassium salt, and cooling, crystallizing and purifying the key intermediate by dropwise adding water to obtain L-2-[(ethoxycarbonyl) amino]-4-phthalimide ethyl butyrate; and (5) finally, hydrolyzing for deprotection, and concentrating and crystallizing to obtain the L-2, 4-diaminobutyric acid dihydrochloride. The method has the advantages of mild reaction conditions, simplicity and convenience in operation, high total yield and the like, and is suitable for large-scale industrial production.

The invention discloses a detection method of a rubber scorch retarder and a conversion product thereof, and belongs to the technical field of chemical detection. According to the technical scheme, the method comprises the following steps: extracting a rubber sample to be detected by using an extracting solution, and then carrying out quantitative analysis on N-cyclohexyl-thiophthalimide and phthalimide by using a liquid chromatograph, a liquid chromatograph adopts a gradient elution mode, a mobile phase in 0-2 min is acetonitrile: water = (30-50): (50-70), a mobile phase in 2-5 min is subjected to gradient from the acetonitrile: water = (30-50): (50-70) to the acetonitrile: water = (80-99): (1-20), and the acetonitrile: water = (80-99): (1-20) is kept in 5-8 min; the ratio of acetonitrile to water is (80-99): (1-20), and the ratio of acetonitrile to water is (30-50): (50-70) in 8-11 min, and the ratio of acetonitrile to water is kept (30-50): (50-70) in 11-13 min. The method has the advantages of simple pretreatment steps, short analysis period and high sensitivity, is suitable for quality control and product inspection in the production process, and can provide a reliable detection means for formula optimization and performance evaluation of rubber products; by adopting the detection method disclosed by the invention, the linear range of CTP and PHT is 0.1-100 mg / L, the detection limit of the method is 0.02-0.04 mg / L, the adding standard recovery rate is 98-103%, the analysis result is accurate, and the sensitivity is high.

This invention discloses a method for synthesizing 6-arylphenanthrene diphenyl compounds. The method involves a dehydrazine radical tandem addition-cyclization reaction of 2-isocyanuric biphenyl and arylhydrazine under air atmosphere and blue visible light irradiation, catalyzed by a molybdenum sulfide / N-hydroxyphthalimide synergistic catalytic system, to generate 6-arylphenanthrene diphenyl compounds. This method has the advantages of readily available raw materials, simple operation, mild reaction conditions, high reaction selectivity and yield, and excellent substrate functional group compatibility.

The present application relates to the technical field of latex paint, and particularly relates to a bamboo charcoal antibacterial and odor-removing latex paint and a preparation method thereof, which comprises nanoscale bamboo charcoal powder, modified chitosan, modified organic nanosheet, ethylene oxide / propylene oxide block copolymer and hydrophobic modified polyurethane; the phthalimide bond formed by the modified chitosan and the modified organic nanosheet is hydrolyzed and broken in the back alkali environment, and two modified substances are released to synergistically play a defense function to protect the integrity of the paint film; the ethylene oxide / propylene oxide block copolymer and the hydrophobic modified polyurethane construct a multi-level stable system, which effectively prevents the flocculation and demulsification between the positively charged quaternary ammonium salt functional substance and the negatively charged emulsion particles.

The present invention relates to phthalimidine-containing bisphenol monomers bearing pendant furyl group of Formula (I) and (co)polymers of Formula (II) obtained by polycondensation of varying mixtures of monomer of Formula (I) and bisphenol-A with aromatic diacid chlorides and the processes for the preparation thereof.

An automatic dishwashing detergent composition suitable for auto-dosing into an automatic dishwashing appliance. The composition includes a combination of at least a first liquid component and a second liquid component that are contained separately from one another within a water insoluble packaging. The first liquid component includes phthalimidoperoxycaproic acid bleach and water and has a pH of less than 7.0. The second liquid component includes citric acid and / or salt thereof builder and water.

The present application provides the following compound (I) or its pharmaceutically acceptable salt, ester, optical isomer, tautomer, stereoisomer, polymorph, solvate, N-oxide, isotopically labeled compound, metabolite, chelate, complex, clathrate or prodrug, and a pharmaceutical composition containing the compound of the present application, and also provides the use of the compound of the present application as a 2-type potassium-chloride co-transporter KCC2 agonist, and the application in the preparation of a drug for a disease related to 2-type potassium-chloride co-transporter KCC2, and a corresponding pharmaceutical composition,

The invention discloses an efficient synthesis method of 2-acetamido-pyridine-3-formic acid, which comprises the following steps: taking 2-amino-3-methylpyridine as a raw material, firstly reacting with acetic anhydride in a micro-channel reactor, and carrying out post-treatment to obtain 2-acetamido-3-methylpyridine; and then, carrying out catalytic oxidation on the intermediate in a water-ethanol system in an oxygen environment by taking iridium trichloride, copper 2-picolinate, N-hydroxyphthalimide and iodobenzene as a catalytic system. And filtering out and recovering the catalyst after the reaction, and carrying out two-step programmed cooling crystallization and activated carbon decoloration refining on mother liquor to obtain a high-purity target product. The method has the advantages of cheap raw materials, adoption of a green solvent and oxygen as oxidants, mild reaction conditions, high product yield and purity, few three wastes, recoverable catalyst, and facilitation of industrial production.

The present application provides a non-aqueous ink composition which is suitably used as a non-aqueous ink composition to be ejected by an inkjet method even if it contains at least one selected from a perinone-based pigment, a diketopyrrolopyrrole pigment, and a halogenated phthalocyanine pigment. The non-aqueous ink composition is a non-aqueous ink composition to be ejected by an inkjet method containing a pigment, a pigment dispersant, and an organic solvent, and the pigment contains at least one of a pigment A1 represented by the following formula (1-1), a pigment A2 represented by the following formula (1-2), and a halogenated phthalocyanine pigment A3, and the pH of the pigment A1 and the pigment A2 is in a range of 3 or more and 9 or less. (In formula (1-1), X1 to X12 each independently represent hydrogen, a halogen atom, an alkyl group having 1 or more and 5 or less carbon atoms which can have a branched chain, an aromatic hydrocarbon group which can be substituted with a hydrogen atom, a cyano group, a nitro group, an amino group, -OH, -COOH, -COO ‑ M + , -SO3H, -SO3 ‑ M + , a phthalimide group which can be substituted with a hydrogen atom, a phthalimidemethyl group, or a heterocyclic compound, M + represents a cation.)(In formula (1-2), X1 to X10 each independently represent hydrogen, a halogen atom, an alkyl group having 1 or more and 5 or less carbon atoms which can have a branched chain, an aromatic hydrocarbon group which can be substituted with a hydrogen atom, a cyano group, a nitro group, an amino group, -OH, -COOH, -COO ‑ M + , -SO3H, -SO3 ‑ M + , a phthalimide group which can be substituted with a hydrogen atom, a phthalimidemethyl group, or a heterocyclic compound, M + represents a cation.

Provided is a method for preparing 8-aminooctanoic acid. Starting from diethyl 2-(6-halohexyl)malonate (III), a crude product of 8-aminooctanoic acid is obtained by a condensation reaction with phthalimide, hydrolysis with dilute sulfuric acid, decarboxylation, and deprotection. High-purity 8-aminooctanoic acid is then obtained by recrystallization in a solvent. The method has the advantages of simplified process, easy availability of raw materials, high yield, ease of separation and purification, less waste, cost-efficiency, ease of industrialization, and the like.

本发明涉及靶向蛋白质降解技术领域，提供了一种基于刚性连接链的PROTAC化合物及制备方法和应用。所述PROTAC化合物通式为星形孢菌素基团‑Linker‑CRBN配体；所述CRBN配体为邻苯二甲酰亚胺类母核结构；所述星形孢菌素基团为吲哚咔唑类母核结构；所述Linker为刚性连接链，一端包含至少一个含氮杂环基团，另一端包含胺基；所述吲哚咔唑类母核与刚性连接链一端的含氮杂环基团上的氮原子相连；所述邻苯二甲酰亚胺类母核与刚性连接链另一端的胺基上的氮原子相连。本发明的PROTAC化合物或包含其的药物组合物在制备用于治疗和 / 或预防肿瘤的药物中的应用，本发明的化合物表现出对肿瘤细胞具有优异的抑制效果。

The invention discloses a synthesis method of an N, N-alkyl substituted amine compound, which utilizes an optimized Gabriel amine synthesis method, and directly uses phthalimide in the presence of alkali, thereby saving the step of converting the phthalimide into sylvite.

The application discloses a method for converting by-products and extracting phthalic acid, which comprises the following steps: evaporating and concentrating salt-containing wastewater containing phthalimide and sodium salt decomposition substances; adding an impurity removal agent, stirring, and entering an automatic candle filter at a temperature of 50-80 DEG C to separate and filter fine impurities; adding the filtrate into an acidification kettle, heating, adding hydrochloric acid into the filtrate at a water temperature of 50-90 DEG C to acidify, and converting sodium phthalate and a series of substances into phthalic acid; cooling, completely separating phthalic acid, and effectively separating salt and water-soluble impurities, and obtaining phthalic acid through solid-liquid centrifugal separation and elution desalting. The method can convert high-COD and high-salt wastewater series organic matters into phthalic acid, can decolorize and purify in the extraction process, can obtain higher-quality phthalic acid, can effectively realize resource utilization, and can reduce wastewater COD to below 5000 mg / L.

The invention belongs to the technical field of synthesis of organic drug intermediates, and particularly relates to an azabicyclo [3, 3, 0] octane medical intermediate and a preparation method thereof. The method comprises the following steps: oxidizing 1, 2, 3, 6-tetrahydrophthalimide to obtain an intermediate II; performing Dieckmann cyclization reaction on the intermediate II to obtain an intermediate III; and reducing functional group ketone on the intermediate III into alcohol under the action of a reducing agent a, reducing acylamino into amido under the action of a reducing agent b, and introducing t-butyloxycarboryl onto the amido to obtain the azabicyclo [3, 3, 0] octane medical intermediate. The preparation method comprises the following steps: carrying out oxidation ring opening and Dieckmann cyclization reaction on an initial raw material, and then carrying out one-pot reduction to obtain the target compound azabicyclo [3, 3, 0] octane medical intermediate by only three steps. The method has the advantages of simple raw materials, low cost, mild reaction conditions, high yield and great reduction of the production cost.

A method for the preparation of a 3-nitro-N—(C1-13 alkyl)phthalimide composition comprises reacting a 3-nitro phthalic acid to provide 3-nitro-phthalic anhydride, optionally in the presence of a solvent, and reacting 3-nitro-phthalic anhydride with a C1-13 alkylamine optionally in the presence of a solvent to provide the 3-nitro-N—(C1-13 alkyl)phthalimide composition comprising 3-nitro-N—(C1-13 alkyl)phthalimide and optionally, 4-nitro-N—(C1-13 alkyl)phthalimide. The 3-nitro-N—(C1-13 alkyl)phthalimide composition can have undetectable levels of 4-nitro-N—(C1-13 alkyl)phthalimide, and consequently, polyetherimides ultimately derived from the 3-nitro-N—(C1-13 alkyl)phthalimide composition can be enriched in 3,3′ linkages and / or exclude 3,4′ and 4′4 linkages. The polyetherimides disclosed can have improved flow and a decreased yellowness index.

The invention relates to the technical field of polypropylene materials, in particular to a polypropylene-based high-strength antibacterial composite material and a preparation method thereof.Polypropylene, a wood fiber modified reinforcing material and a nano-silver synergistic quaternary ammonium salt antibacterial material are blended, so that the multiple advantages of high strength and antibacterial property are achieved; wherein the wood fiber modified reinforced material is prepared by modifying carboxyl-terminated liquid nitrile rubber with wood fibers and then grafting N-(2, 3-epoxypropyl)-phthalimide, the wood fibers have high strength and rigidity, the carboxyl-terminated liquid nitrile rubber has flexibility, and the N-(2, 3-epoxypropyl)-phthalimide has good mechanical properties. A benzene ring structure of 1, 3-epoxypropyl)-phthalimide can increase the rigidity of a molecular chain, so that the strength and toughness of polypropylene are improved, the nano-silver and quaternary ammonium salt synergistic antibacterial material is prepared by loading nano-silver on quaternary ammonium salt functionalized porous resin, quaternary ammonium salt and nano-silver synergistically resist bacteria, and the porous structure slows down the dissolution rate of nano-silver, so that the antibacterial effect of the nano-silver and quaternary ammonium salt synergistic antibacterial material is improved. The efficient and long-term antibacterial effect is achieved.

The invention belongs to the field of organic synthesis, and particularly relates to a synthesis method of N-hydroxymethyl phthalimide. The method comprises the following steps: 1) constructing a cerium-based ternary MOFs precursor, and carrying out active immobilization by taking the cerium-based ternary MOFs precursor as a carrier to construct and form a composite catalyst; (2) a sodium acetate-phosphate buffer solution is used as a reaction base solution, a composite catalyst and reaction raw materials are added into the reaction base solution, the reaction raw materials are paraformaldehyde and phthalimide, and the materials are stirred and mixed to be uniform to construct a reaction system; and 3) placing the reaction system in a low-temperature constant-temperature water bath, and carrying out a photocatalytic reaction to synthesize the N-hydroxymethyl phthalimide. The active composite catalyst is formed by constructing a cerium-based ternary MOFs precursor and loading N-hydroxymaleimide, the traditional high-temperature reaction condition is changed into a low-temperature safe photocatalytic water bath reaction condition, the reaction efficiency is greatly improved, and the method is more environmentally friendly.