345 results about "Phthalimides" patented technology

A polymer, article and blend including a polymer low yellowness index comprising structural units derived from a 2-hydrocarbyl-3,3-bis(4-hydroxyaryl)phthalimidine is disclosed.

Synthesis of a chemical compound having the formula A-B-C that may serve for applications such as drug delivery where A is a chemiluminescent, moiety, B is a photochromic moiety, and C is a biologically active moiety where A-B-C may serve as a prodrug. Novel synthetic methods of the present invention to form the prodrug comprised the steps of (1) forming a benzophenone, (2) forming a diaryl ethylene, (3) attaching a phthalimide moiety to at least one of the aryl groups of the ethylene to form a phthalimide-ethylene conjugate, (4) condensing two ethylene-phthalimide conjugates to form a phthalimide-pentadiene conjugate, (5) converting the phthalimide to the phthalhydrazide by reaction with hydrazine to form a carrier compound according to the present invention, and (6) reacting the carrier compound with an nucleophilic moiety of the drug to form the corresponding prodrug. Alternatively the carrier can be prepared by using the halo-substituted diaryl ethylene to make the corresponding cationic leuco dye-like compound with known methods. The cationic compound then is protected by reacting with a nucleophile and coupled with the aminophathalimide by palladium-catalyzed amination to form the protected phthalimide-pentadiene conjugate. The latter is refluxed with hydrazine to convert its phthalimide to the phthalhydrazide and acidified to give the carrier. An additional aspect of the present invention relates to the use of these compounds as antiviral agents for the treatment of viral infections such as HIV and as anticancer agents for the treatment of cancers such as bowel, lung, and breast cancer.

The present invention relates to thermoplastic high-Tg polycarbonates and moulding materials which are distinguished by improved thermal properties and improved mechanical properties, in particular by reduced thermal expansion. The present invention furthermore relates to a process for the preparation of these polycarbonates. In particular, this invention relates to polycarbonates which the structural unit which derives from phthalimide of the formula (I) and polycarbonate compositions and moulding materials therefrom as well as a process for the preparation of these polycarbonates, and the use thereof, in particular as reflectors and display substrates.

The invention discloses an antibacterial polypropylene plastic and a preparation method of the antibacterial polypropylene plastic. The antibacterial polypropylene plastic comprises the following components by weight: 100 parts of polypropylene, 0.2-0.6 parts of antibacterial agent and 0.1-0.5 parts of dispersant, wherein the antibacterial agent is one or a mixture of nanometer zinc oxide, nanometer silver oxide, polyhexamethyleneguanidine phosphate and N-(trichloromethylthio) phthalimide. The antibacterial polypropylene plastic still has good effects of inhibiting and killing bacteria and preventing mould after being used for a long time, and is not influenced by factors such as illumination and temperature. The antibacterial polypropylene plastic can be easily processed by an injection process into automotive upholsteries in various shapes, such as an inner cover plate for a glove box, a glove box hopper, an auxiliary instrument board body, a storage box gasket and a panel storage box.

The invention provides a synthetic method for sulforaphane and belongs to the field of drug synthesis. The method comprises the following steps that: after amino in 4-amino-1-butanol is protected by Boc groups, hydroxy in 4-amino-1-butanol is changed into methanesulfonyl ester by methanesulfonyl chloride, and then the resultant reacts with sodium methyl mercaptide to produce 4-methylthio butyl-1-tert-butoxycarbonylamide; Boc protective groups are removed under acidic condition to obtain 4-methylthio-1-butylamine; 4-methylthio-1-butylamine reacts with carbon disulfide for one hour in the presence of triethylamine and p-toluenesulfonyl chloride is added for treatment for half an hour to produce 4-methylthio butyl-1-isothiocyanate; and at last 4-methylthio butyl-1-isothiocyanate is oxidized by m-CPBA to produce sulforaphane. According to the invention, complex hydrazinolysis of phthalimide in aftertreatment is avoided and toxic thiophosgene is not needed in the preparation of isothiocyanate; overall yield of sulforaphane is 64%, substantially higher than the overall yield of 8% reported in literature; the whole preparation process is simple and time-saving and is suitable for large scale production.

The invention relates to a thermally-activated delay fluorescent material. The thermally-activated delay fluorescent material is a 4,5-position substituted phthalimide derivative, R1 is an electron-rich aromatic amine substituent group containing at least one nitrogen, amino nitrogen of the electron-rich aromatic amine substituent group is connected with phthalimide, and R2 is any one of saturated aliphatic group, unsaturated aliphatic group, aryl and hetero aryl. The 4,5-position substituted phthalimide derivative has the advantages of having thermally-activated delay property, high fluorescence quantum yield and easy derivatization characteristics and the advantages of good stability and the like. A preparation method of the thermally-activated delay fluorescent material is simple in synthesis, the raw materials are cheap, the product yield is high, and the material can be prepared in a large-scale mode. The invention provides an organic electroluminescence device. The organic electroluminescence device has the advantages of high efficiency, low driving voltage, long service life, stable light emitting and the like. The thermally-activated delay fluorescent material provided with a 4,5-position substituted phthalimide structure and the organic electroluminescence device based on the material have a very good application prospect.

The invention relates to the action of phthalimide derivatives of formula I and II in the preparation of medicament against angiogenesis, wherein the definitions of each substituent group are described in the specification.

The invention relates to a 3-methylene-indole-2-ketone derivative and a preparation method thereof. The derivative is synthesized by taking N-methyl-N-phenyl-hydrocinnamamide or N-aryl phenylpropargyl acylamide and phthalic imide as substrates through tandem reactions such as C-H activation/ acetylene hydrocarbon palladinization/cross coupling and so on, based on the catalysis of Pd<II>/Pd<IV> under the coaction of a palladium catalyst and an oxidizing agent, then ethyl acetate is added, the mixture is scrubbed by common salt, an aqueous phase is then extracted by the ethyl acetate, an organic layer is collected, and the 3-methylene-indole-2-ketone derivative is prepared through drying, condensation and column chromatography. The preparation method has the advantages of simple and convenient reaction operation, short reaction steps, simple conditions, short time, low cost, and high yield, and is worthy to be popularized and applied.

The invention belong to the art of preparation technique of 2, 3', 3, 4'-diphenyl sulfide tetra-acid dianhydride. It adopts sodium hydrosulfide as a sulfuration agent to react N- substituted- 4- or- 3- phthalimide chloride non-protonic polar solvent to generate intermediate product N- substituted- 4- or- 3- phthalimide sulfhydryl substituted; the latter reacting N- substituted- 3- or- 4- phthalimide chloride non-protonic polar solvent in faintly alkaline condition to generate asymmetric N, N'- double substituted- 2, 3', 3, 4'-diphenyl sulfide tetra imide, hydrolyzing, acidifying, by toluene and dimethylbenzene with water to prepare directly asymmetric2,3',3,4'- diphenyl sulfide tetra-acid dianhydride, which can be used to synthesize polyimide.

To provide a composition for a wire coating material, requiring no electron irradiation crosslinking and a less filler, that can produce a crosslinked coat having a high heat resistance, gel fraction and peel property at high temperature, and provide an insulated wire, and a wiring harness. A wire coating material composition contains (A) silane-grafted polyolefin, (B) undenatured polyolefin, (C) functional-group modified polyolefin modified by functional groups of a carboxylic acid group, an acid anhydride group, an amino group and an epoxy group, (D) a bromine flame retardant having a phthalimide structure or the flame retardant and an antimony trioxide, (E) a crosslinking catalyst batch containing a resin containing a crosslinking catalyst, and (F) a zinc oxide and an imidazole compound or a zinc sulfide, (G) a triazine hindered phenolic antioxidant having a melting point of 150 degrees C. or more, and (H) a triazole derivative or a hydrazide metal deactivator.

The invention relates to a method for synthesizing a dianhydride monomer, in particular to a method for synthesizing an aromatic HQEDA monomer. The method adopts a 3(4) substituted phthalimide to prepare HQEDA and provides novel middle steps for preparing the HQEDA. The method comprises the following steps: preparing a 3 (4) substituted-N-alkyl (aryl) phthalimide from the 3(4) substituted phthalimide through Gabriel reaction principle or by adding a salifying agent and halocarbon into an apolar aprotic solvent to react; and using the prepared 3 (4) substituted-N-alkyl (aryl) phthalimide to prepare bis imide and the bis ether anhydride. The method has the advantages that raw materials are easily available, preparation method is simple and easy to operate, and the purity and yield of the prepared 3 (4) substituted-N-alkyl (aryl) phthalimide are obviously higher than that of the prior method.

The invention provides a preparation method of N-phthaloyl protected 1-substituted homotaurine. The method comprises: conducting free radical addition to terminal olefin by dithiocarbonic acid-O-alkyl-S-phthalimidemethyl ester so as to obtain corresponding xanthate, then carrying out oxidation to prepare N-phthaloyl protected 1-substituted homotaurine, then performing acid or base catalyzed hydrolysis or hydrazinolysis, thus obtaining 1-substituted homotaurine. The preparation method of the invention has simple and easily available raw materials, convenient operation, and no need for a tedious desalting and purifying process, thus being especially suitable for large scale industrial production. And the prepared compound can be use as a nutrient, a medicament, an enzyme inhibitor, an antimicrobial agent, a surfactant, a plant growth regulator, and a raw material for preparing sulfono-peptides, etc.

Disclosed are an aqueous pigment dispersion for inkjet ink, a method for producing the same, and an ink composition for inkjet recording which mainly contains the aqueous pigment dispersion for inkjet ink. The method for producing the aqueous pigment dispersion for inkjet ink is characterized by comprising a kneading step wherein a mixture including a styrene resin, a quinacridone pigment, a phthalimidomethylated quinacridone compound, an alkali metal hydroxide and a wetting agent is kneaded for producing a solid colored kneaded material, and a dispersing step wherein the thus-obtained solid colored kneaded material is dispersed into an aqueous medium.

The invention relates to the technical field of chemical synthesis of medicines, in particular to a preparation method of melatonin. The preparation method of the melatonin comprises the following steps: (a) subjecting phthalimide, 1,3-dichloropropane, sodium iodide and ethyl acetoacetate to a reaction in a solvent under the action of alkali to obtain a compound I; (b) performing a ring closing reaction on the compound I and p-methoxyphenyl diazonium salt in the presence of alkali and a solvent to obtain a compound II; (c) hydrolyzing the compound II under an alkaline condition, and carrying out decarboxylating under an acidic condition to obtain a compound III; and (d) carrying out an acetylation reaction on the compound III to obtain melatonin. According to the preparation method, phthalimide, 1,3-dichloropropane, ethyl acetoacetate and the like are used as raw materials, and the price of the raw materials is low; the intermediate compound I can be obtained through a one-step method,so reaction steps and time are shortened; moreover, the conditions of each reaction step are relatively mild, the raw materials are easy to obtain, and high yield can be obtained.

The invention discloses a water-soluble ink for printing a metal product, a ceramic product and a product made of a metal and ceramic composite material, as well as a method for obtaining a product made of a required material by plasticizing, unsticking and sintering a molding product printed by the ink. The ink comprises components in mass ratio as follows: 30%-70% of material components, 1%-9% of high polymer material components and 69%-21% of water, wherein the material components include metal, alloy, ceramic and the like, and the high polymer material components include one or more of caprolactam, 2-pyrrolidone, polytrimethylene terephthalate, polybutylene terephthalate, poly(ethylene glycol) diacrylate, dipropylene glycol methyl ether acetate, phthalic anhydride, phthalimide, polyacrylamide, polyacrylic polymethacrylic acid and copolymer thereof, polyvinyl alcohol, polyethylene glycol, polyoxyethylene, polyvinyl pyrrolidone, polymaleic anhydride, KEPS resin, poly dimethyl diallyl ammonium chloride, water-soluble cellulose, single-stranded polyurethane and the like.

The invention relates to a zinc coordination polymer and a preparation method and application thereof. The simple structural formula of the coordination polymer is [Zn3 (mu3-Hbptc) 2 (mu2-4, 4 '-bpy)2 (H2O) 4] n.2nH2O, wherein H4bptc is 2, 3, 3', 4 '-biphenyltetracarboxylic acid, and 4, 4'-bpy is 4, 4 '-bipyridine. The coordination polymer is prepared by a hydrothermal method. The preparation method comprises the following steps: dissolving Zn (NO3) 26H2O, N, N '-di-(3-pyrazinyl)-4, 4'-phthalimide (DPBA) and 4, 4 '-dipyridyl into a proper amount of water according to the molar ratio of 2: 1:1; adjusting the pH value to 5 with 0.50 mol/L KOH, stirring for 30 min, carrying out a reaction in a polytetrafluoroethylene tube at 120 DEG C for 72 h, naturally cooling to room temperature to obtain colorless bulk crystals, washing with distilled water, and carrying out vacuum drying collection. Fluorescence of the coordination polymer in an aqueous solution can be selectively quenched by Cu <2 + > and Ni < 2 + >, i.e. a good fluorescence recognition effect on Cu < 2 + > and Ni < 2 + > can be realized, and the coordination polymer can be repeatedly used and can be used as a fluorescence sensor for efficiently detecting Cu < 2 + > and Ni < 2 + >, and the fluorescence detection limits are 0.0456 mu M and 0.0559 mu M respectively.

The present invention relates to preparation process of 2-[2-(2, 2, 2-trifluoro ehtoxy)] phenoxy ethamine. The preparation process includes the etherification of 2-(2, 2, 2-trifluoro ehtoxy) phenol as material with 1, 2-dibromoethane to obtain 2-[2-(2, 2, 2-trifluoro ehtoxy)] phenoxy bromethane, the alkylation of 2-[2-(2, 2, 2-trifluoro ehtoxy)] phenoxy bromethane with phthalamide, and final aminolysis with hydrazine hydrate to obtain 2-[2-(2, 2, 2-trifluoro ehtoxy)] phenoxy ethamine.