The application discloses a Shiniu antipyretic oral liquid which is prepared by processing the following traditional Chinese medicines and water, wherein the traditional Chinese medicines comprise the components by mass percent: 39% of raw gypsum, 6.5% of cornu bubali, 3.25% of radix scutellariae, 3.25% of coptidis rhizome, 6.5% of radix scrophulariae, 6.5% of radix rehmanniae, 1.96% of fructus forsythiae, 1.96% of platycodon grandiflorum, 1.96% of bupleurum, 1.96% of calvatia gigantea, 1.96% of fructus arctii, 1.96% of gardenia jasminoides, 0.67% of stiff silkworm, 0.67% of rhizoma cimicifugae, 1.96% of radix isatidis, 1.3% of tangerine peel, 1.3% of liquorice, 3.25% of rhizoma anemarrhenae, 2.17% of the root bark of the peony tree, 2.17% of red peony root, 6.5% of fresh bamboo leaves, 2.17% of American ginseng and 1.08% of fructus amomi. The Shiniu antipyretic oral liquid has the advantages of good heat clearing effect, low side effect and good patient tolerance.