11 results about "Postoperative inflammation" patented technology

The application relates to the technical field of medical suture materials, and particularly discloses a non-absorbable suture with tissue self-adaptive performance, which comprises a core layer, a transition layer and an outer layer; the core layer and the transition layer are fixed through hot melt adhesion, and the outer layer is coated on the surface of the transition layer through electrostatic spinning; the core layer is a polyether ether ketone fiber with a diameter of 50-100 mu m and a tensile modulus of greater than or equal to 3 Gpa; the transition layer is a nickel-titanium alloy wire braided net with a thickness of 40-60 mu m, and the wire diameter of the nickel-titanium alloy wire is 20-30 mu m; and the outer layer is a poly-lactic acid-glycolic acid copolymer coating layer containing nano-hydroxyapatite with a thickness of 30-50 mu m; and the application further provides a preparation method of the non-absorbable suture. The non-absorbable suture has the advantages of tissue self-adaptive performance, persistent mechanical support and bioactivity, can effectively avoid tissue cutting, abrasion and suture loosening, and can reduce the incidence of postoperative complications such as inflammation and pain.

The present application relates to a kind of preparation compositions containing the preparation method of loxoprofen derivative shown in general formula (I).The composition is a kind of analgesic antipyretic for preventing and treating rheumatoid arthritis, rheumatoid arthritis, osteoarthritis, joint deformity, gout, lumbago, neck shoulder wrist syndrome and periodontitis, cold, acute respiratory inflammation, such as postoperative inflammation of the diseases of the drug composition, its composition is characterized in that the mass percentage of loxoprofen derivative is 0.5%-5.0%w / w;Including physiologically acceptable crystal inhibitor;And at least one pH regulator.The pharmaceutical composition provided by the present application, compared with the preparation of loxoprofen derivative external preparation of the current existing technical means or the method reported in the public literature, solves the problem of active ingredient crystallization of such preparation, and achieves good effect.

The utility model discloses an instrument applied to lacrimal passage probing, relates to the technical field of medical auxiliary appliances, and solves the problems that the diameter of an existing lacrimal passage probe is fixed, when the lacrimal passage dredging radius of a patient needs to be changed after the lacrimal passage probe is inserted, the lacrimal passage probe needs to be pulled out and inserted again, the operation efficiency is low, the operation time is increased due to multiple probing operations, and the operation difficulty is high. Psychological stress is caused to the patient; and repeated expansion easily causes lacrimal passage mucosa injury and aggravates postoperative inflammatory response. The utility model provides an instrument applied to lacrimal passage probing, which comprises an outer tube and an inner core, the outer tube is sleeved on the inner core, the inner core comprises a guide wire and a dilation cone which are integrally connected, and the outer tube is in threaded connection with the dilation cone; the guide wire is sleeved with an air bag, the air bag is arranged between the guide wire and the outer tube, and one end of the air bag is connected with the dilation cone. The outer diameter of the lacrimal passage can be expanded in the probing process, so that the lacrimal passage is expanded; and meanwhile, certain stability is achieved, and displacement cannot occur in the operation process.

This invention discloses a method for constructing an early prediction model of hydrocephalus secondary to intraventricular tumors based on the dynamic changes of inflammatory factors after surgery, belonging to the field of medical data processing and model construction. The method includes: acquiring the concentration values ​​of inflammatory factors and the hydrocephalus outcome of biological samples at multiple postoperative time points; calculating quantitative characteristic parameters characterizing the dynamic evolution of the inflammatory response, such as the dynamic change rate, cumulative load, and acceleration, based on the concentration values; and training a deep learning model using the quantitative characteristic parameters and clinical baseline data as input features, with the hydrocephalus outcome as the label. This invention achieves early quantitative warning of hydrocephalus risk, significantly improving the accuracy, sensitivity, and specificity of prediction. It solves the technical problem of existing technologies relying on post-operative monitoring methods such as imaging and lacking early biochemical warning capabilities.

The invention discloses a femtosecond laser operation flat-topped beam shaping optical system which comprises a laser, a beam expander, a DOE shaping module and a focusing scanning module. The laser is used for outputting a femtosecond Gaussian laser beam, and the femtosecond Gaussian laser beam sequentially passes through the beam expander, the DOE shaping module and the focusing scanning module and then acts on an operation area; the beam expander is used for expanding the diameter of the femtosecond Gaussian laser beam to the beam diameter used for cutting the light path; the DOE shaping module comprises a DOE diffractive optical element; the DOE diffractive optical element is arranged on a path of the femtosecond Gaussian laser beam and is used for converting an incident Gaussian beam into a flat-topped beam with uniformly distributed energy through phase modulation; the flat-topped light beam has no local energy peak value, thermal damage and excessive ionization of traditional Gaussian laser to normal tissues of eyes are avoided, postoperative inflammatory response is light, the tissue recovery speed is increased, and the risk of operative complications is reduced.

The application discloses a punching device with notch trimming function for anastomat titanium nail production, and relates to the technical field of metal punching, which comprises a bending unit and an anti-abrasion unit. The bending unit comprises force applying blocks and a force receiving block, and the anti-abrasion unit comprises a rotating block and a roller. After the titanium nail is punched by a hydraulic cylinder, the titanium nail is conveyed to the bending unit. When the titanium nail is bent, the force applying blocks on both sides of the force receiving block move synchronously to the force receiving block. The titanium nail column surface generates a pushing force on the roller on the rotating block. Because the rotating block is rotationally connected with the force applying block, the rotating block rotates around the connecting point until the rollers arrayed in the rotating block completely adhere to the titanium nail column surface, that is, the two sides of the titanium nail are bent by 90 degrees. In the bending process, the roller on the rotating block converts the traditional sliding friction into rolling friction, effectively reduces the abrasion of the titanium nail surface, avoids the emergence of defects such as burrs and micro-cracks, and reduces the risk of intraoperative tissue damage and the possibility of postoperative inflammatory reaction.

The application provides a kind of eye drop composition and its preparation method and application, belong to ophthalmic preparation technical field.The eye drop composition used in the application includes the following components: brimonidine tartrate, hyaluronic acid, collagen, trehalose, injection water;By compounding each component, a kind of eye drop capable of realizing brimonidine tartrate sustained release, prolonging the time of antihypertensive effect, and having the characteristics of reducing blinking discomfort, long-acting moisturizing, anti-inflammatory soothing, mild antiseptic, etc. is prepared;The eye drop of the application is helpful to glaucoma, high eye pressure, dry eye, postoperative inflammation or allergy, preservative-sensitive or preservative-allergic population, improves the quality of life, relieves the disease.

The utility model relates to the field of biomedical engineering provides a kind of intraocular lens, to be able to alleviate postoperative inflammation.The utility model gets intraocular lens, including optical part, the optical part has first drug loading hole, the first drug loading hole is bottomed hole, in the optical part one surface opening, for accommodating drug.The above structure is adopted, since optical part has first drug loading hole, the first drug loading hole is bottomed hole, in the optical part one surface opening, therefore can fill relevant drug in drug loading hole, drug is released through the opening of optical part surface, so as to can reduce postoperative inflammation, inhibit lens epithelial cell migration, reduce the incidence of posterior capsule opacity.

The application provides a method and application for comprehensively extracting eicosanoid containing EPA and ARA from Phaeodactylum tricornutum, establishes a complete process chain of "algal culture-algal mud acquisition-ASE rapid extraction of microalgal oil-SPE enrichment-semi-preparation HPLC purification", the composition ratio of the anti-inflammatory mediators is clear, and the structure is identified by high performance liquid chromatography; the existing literatures and patents do not disclose that the algal strain can simultaneously enrich the combination of the above-mentioned various anti-inflammatory mediators. And the raw material of Phaeodactylum tricornutum is derived from marine diatoms which can be cultured on a large scale, there is no risk of pesticide residue of terrestrial plants, and there is no organic chlorine solvent in the production process, which meets the requirements of FDA / EFSA on natural marine source functional ingredients; can be simultaneously used for anti-inflammatory prescription drugs, postoperative inflammation relief food and soothing and repairing cosmetics, and has a wide market adaptation.

The invention provides application of a qi stagnation and stomachache tablet in preparation of a medicine for preventing and / or treating postoperative intestinal obstruction. The qi stagnation and stomachache tablet is prepared from the following components in parts by weight: 300 to 400 parts of radix bupleuri, 350 to 450 parts of fructus aurantii, 350 to 450 parts of vinegar-processed rhizoma cyperi, 420 to 520 parts of radix paeoniae alba and 150 to 250 parts of honey-fried licorice root. The preparation method of the qi stagnation and stomachache tablet comprises the following steps: step 1, taking 5-20% of vinegar-processed rhizoma corydalis and 10-35% of radix paeoniae alba, and crushing into raw medicine powder; step 2, taking the remaining medicinal materials, adding water, decocting twice, decocting for 0.5-4 hours for the first time and decocting for 0.5-3 hours for the second time, combining decoction liquid, filtering, concentrating filtrate into thick paste, and performing spray drying to obtain dry powder; and 3, uniformly mixing the dry powder and the raw medicine powder, adding auxiliary materials, tabletting, and coating with a film to obtain the traditional Chinese medicine composition. According to the present invention, the treatment value of the qi stagnation and stomachache tablet on the postoperative intestinal obstruction is determined for the first time, the postoperative inflammatory reaction is subjected to targeted regulation through the multi-component synergistic effect, the intestinal motility recovery is effectively promoted, the safety is high, the brand new traditional Chinese medicine treatment scheme is provided for the clinical prevention and treatment of the postoperative intestinal obstruction, and the blank of the lack of the targeted drug in the field is filled.

The invention discloses a punching device with a notch trimming function for anastomat titanium nail production, and relates to the technical field of metal punching, the punching device comprises a bending unit and an anti-abrasion unit, the bending unit comprises a force application block and a stress block, the anti-abrasion unit comprises a rotating block and a roller, after a hydraulic cylinder completes titanium nail punching, the rotating block is driven to rotate, and the rotating block is driven to rotate; when the titanium nail is conveyed to the bending unit and is bent, force application blocks on the two sides of a stress block synchronously move towards the stress block, the cylindrical surface of the iron nail can generate thrust on rollers on a rotating block, and the rotating block is rotationally connected with the force application blocks and rotates around a connecting point until the rollers distributed in an array mode in the rotating block are completely attached to the cylindrical surface of the titanium nail. The two sides of the titanium nail are bent by 90 degrees, in the bending process, traditional sliding friction is converted into rolling friction through the rollers on the rotating blocks, abrasion to the surface of the titanium nail is effectively reduced, burrs, microcracks and other defects are avoided, and the risk of tissue damage in an operation and the possibility of postoperative inflammatory reaction are reduced.