18 results about "Tissue integration" patented technology

This invention discloses a bioactive glass and its preparation method, belonging to the field of bioactive glass technology. It aims to solve the problems of insufficient synergistic effect between antibacterial efficacy and bone-promoting activity in existing materials, as well as the inability to monitor in vivo degradation processes in real time. The bioactive glass comprises 44-48 parts silica; 22-27 parts calcium oxide; 22-27 parts sodium oxide; 5-7 parts phosphorus pentoxide; 2-4 parts europium zinc complex; 10-20 parts chitosan; 1-5 parts lidocaine; and 2-5 parts dilute acetic acid solution. The addition of the europium zinc complex promotes bone formation and enhances antibacterial activity, achieving a highly efficient synergy between anti-infection and tissue regeneration. Simultaneously, it provides optical tracking capabilities, allowing for non-destructive real-time monitoring of the material's degradation behavior and tissue integration in vivo via fluorescence imaging. This invention offers superior material performance and a simple preparation process, providing an innovative solution for the repair of infected bone defects.

This invention provides a medical repair membrane with an orthogonal crack-limiting structure and its preparation method. This invention relates to the field of biomedical materials technology. The medical repair membrane of this invention comprises at least two electrospun fiber layers, which intersect to form an orthogonal fiber structure. Layer B, facing tissue integration, adopts a coaxial core-shell structure. The shell layer contains biodegradable polymers and bioactive components, while the core layer is a biodegradable polymer. The structure of this invention effectively inhibits crack propagation and improves the structural stability of the material. Simultaneously, the core-shell structure enables controlled release of active components and tissue-selective induction, balancing mechanical properties and biocompatibility. The medical repair membrane is suitable for soft tissue defect repair, such as dura mater repair, fascia repair, pericardial repair, and hernia repair.

A medical device includes a surgical needle, an elongated suture, and an intervening segment. The elongated suture has a first end proximate to the needle and a second end located away from the needle. The elongated suture also includes a plurality of fibers defining a mesh wall between the first and second ends. A plurality of pores extend through the mesh wall, at least some which are in the macroporous size range of greater than 200 microns for facilitating tissue integration when introduced into a body. The intervening segment is disposed between and connected to either or both ends of the elongated suture and the needle. The intervening segment includes one or more fibers of the plurality of fibers and has a cross-sectional dimension smaller than a cross-sectional dimension of the mesh wall such that the intervening segment facilitates indirect attachment of the elongated macroporous mesh suture to the needle.

The application discloses a mineralized facial implant line and a preparation method thereof, and belongs to the technical field of medical implant materials. The method comprises the following steps: performing microphysical etching on the surface of a high-molecular implant line to form a uniform micro-pit structure; adsorbing a polydopamine film on the etched surface; performing biomimetic mineralization in a supersaturated calcium-phosphorus solution containing zinc ions to form a zinc-doped hydroxyapatite coating; and covalently grafting an enzyme-sensitive drug conjugate on the surface of the coating. The implant line prepared by the method has excellent biocompatibility, strong coating bonding force, good tissue integration capacity and intelligent drug release function, can effectively reduce inflammatory reactions and prevent line body displacement, and improves the durability and safety of facial lifting.

The demand for biocompatible dental materials has increased significantly, particularly in vital pulp therapy, due to the need for materials that promote tissue regeneration and long-term success. This invention introduces a novel Nanocarbon Platelets-Enhanced Portland Cement Composite that combines the well-established properties of Portland cement with the advanced mechanical and biological characteristics of graphene oxide nanocarbon platelets. This composite is designed to serve as both a restorative material and an agent for vital pulp therapy. The integration of graphene oxide nanocarbon platelets enhances the composite's mechanical properties while maintaining superior biocompatibility. This ensures the material supports cell viability and proliferation, crucial for successful tissue integration and regeneration. The unique formulation also improves the sealing ability of the cement, providing exceptional protection against bacterial infiltration and aiding in the preservation of dental structures. This invention aims to address the limitations of existing Portland cement-based materials, such as weak mechanical properties and potential cytotoxicity, by offering a more robust and biocompatible alternative. The composite is developed with a specific focus on dental applications, ensuring it meets the demands of modern restorative and endodontic procedures. The Nanocarbon Platelets-Enhanced Portland Cement Composite offers a cost-effective solution that can be easily integrated into existing clinical practices. Its development represents a significant advancement in materials science, with potential applications beyond dentistry, such as in orthopedic and craniofacial reconstruction. This composite sets a new standard for dental materials by combining mechanical strength, biocompatibility, and ease of use, promising improved outcomes for both patients and practitioners.

Described herein includes a hair cutting device configured for safe, efficient optical hair cutting through external waveguide light guiding and temporary tissue integration. The device comprises an optical waveguide configured to guide laser light outside the waveguide material along a cutting surface of a cutting region of the waveguide and / or accept organic tissue (hair) as a temporary integral component of the waveguide system. Applications include personal grooming devices, professional hair cutting implements, and medical cutting instruments with inherent safety and efficiency advantages over mechanical and prior art optical approaches.

The application discloses a photocured biological tissue adhesive patch and a preparation method and application thereof, and relates to the technical field of biomedical materials. The photocured biological tissue adhesive patch comprises a composite polymer soluble microneedle, wherein the photocured biological tissue adhesive patch is prepared from a prepolymer solution comprising the following components: (1) methacrylated gelatin (GelMA); (2) oxidized dextran (ODex); (3) polyvinyl alcohol (PVA); and (4) a photoinitiator, wherein the photoinitiator comprises LAP; and the weight ratio of the methacrylated gelatin, the oxidized dextran, the polyvinyl alcohol and the photoinitiator is (5-10):(3-6):(3-8):(0.05-0.3). The photocured biological tissue adhesive patch has excellent tissue integration promotion effect, is particularly suitable for a conjunctival transplantation and other surgeries requiring high-quality tissue integration, has wide clinical application adaptability and good industrialization prospect.

This invention provides an electrospun gastric perforation patch based on Ag / Zn bimetallic MOF and its preparation method. The gastric perforation patch comprises a tissue integration layer, an antibacterial drug-loaded core layer, and an anti-adhesion layer integrally formed by electrospinning. The antibacterial drug-loaded core layer is composed of Ag / Zn bimetallic MOF loaded with antifungal drugs and a biodegradable polymer material. In the Ag / Zn bimetallic MOF, the molar ratio of zinc to silver is (8:1) to (12:1), and the antifungal drug is voriconazole or amphotericin B. This invention combines the broad-spectrum antimicrobial properties of Ag / Zn bimetallic MOF with a three-layer functional gradient design, enabling the patch to adhere firmly to tissue without sutures. It can actively prevent infection, inhibit adhesion, promote tissue regeneration, and gradually degrade and absorb postoperatively, significantly reducing the risk of foreign body reaction, infection, and recurrence, demonstrating excellent biocompatibility and broad clinical application prospects.

The invention discloses a three-layer artificial soft tissue composite repair membrane with progressive variable porosity and a preparation method and application of the three-layer artificial soft tissue composite repair membrane in the field of biomedical tissue engineering.The repair membrane is composed of three composite layers, and the first composite layer comprises a spiral disordered fiber layer and a first ordered fiber layer; the second composite layer comprises a spiral disordered fiber layer and a second ordered fiber layer, and the third composite layer is a middle disordered fiber layer. The middle disordered fiber layer is formed by stacking fibers which are spirally and disorderly arranged, and the ordered fiber layers on the two sides are formed by stacking fibers which are linearly arranged. And each layer of material is a biodegradable natural or synthetic polymer. The membrane can be loaded with active substances or subjected to surface modification. The preparation method adopts a thermal method and a near-field direct-writing printing process, and is realized by respectively printing each composite layer and then carrying out thermal bonding. The membrane is unique in structure, can effectively guide cell growth and promote tissue integration and regeneration, and is suitable for the field of tissue engineering scaffolds.

The application relates to the technical field of biology, and particularly discloses an artificial synthetic dermis loaded with subacromial synovial mesenchymal stem cell composite patch as well as a preparation method and application thereof. The artificial synthetic dermis loaded with subacromial synovial mesenchymal stem cell composite patch has the advantages of convenient raw material source, no immune rejection, no supply area complications, no disease transmission risk and the like. Moreover, the composite patch provides initial mechanical support, and improves the tendon-bone interface microenvironment through the paracrine effect (including pro-angiogenic related factors) of the subacromial synovial mesenchymal stem cells, promotes host cell infiltration and blood vessel ingrowth, and enhances tissue integration and rotator cuff healing.

The application discloses a multifunctional biomaterial for posterior sclera reinforcement, which is prepared by using layer-by-layer self-assembly (LbL) surface functionalization technology to coat silk fibroin (SF) on the surface of small intestinal submucosa (SIS), and preparing a light cross-linked SF (SFMA) microgroove coating with anisotropic characteristics on one side of the SIS for guiding cell arrangement and growth, promoting tissue regeneration and repair; and preparing a light cross-linked SF and sodium hyaluronate (SF-SH) mixed coating on the other side for improving biocompatibility and adhesion, so as to realize preparation of a multifunctional posterior sclera reinforcement biomaterial with controllable mechanical and degradation properties and capable of promoting surrounding tissue regeneration. The posterior sclera reinforcement biomaterial is cross-linked in the LbL mode to avoid toxic substance residues generated by cross-linking of SIS and traditional glutaraldehyde. The light cross-linked SFMA microgroove coating on one side can not only realize directional growth of fibroblasts, but also realize directional arrangement of collagen type I secreted by the cells, and effectively realize tissue integration. Meanwhile, the light cross-linked SF-SH mixed coating on the other side has excellent adhesion, which is helpful for positioning and attaching of the reinforcement material, and is of great significance to improving the effect of a posterior sclera reinforcement (PSR) operation and promoting long-term stable and effective treatment of pathological high myopia by using the biomaterial.

This invention discloses an implantable medical device comprising a polyethylene glycol diacrylate hydrogel matrix and monodisperse guanine peptide nucleic acid self-assembled microspheres immobilized within the polyethylene glycol diacrylate hydrogel matrix. The guanine peptide nucleic acid self-assembled microspheres exhibit a spatial quasi-periodic distribution within the hydrogel matrix characterized by short-range order and long-range disorder. This implantable medical device combines the light-harvesting advantages of biomimetic structures, the wide bandgap photoelectric properties of bio-organic semiconductors, and the flexible tissue integration capabilities of hydrogels to obtain an amorphous photonic crystal material with programmable optical properties and wide bandgap semiconductor properties. This product aims to achieve efficient, stable, and biosafe neurophotomodulation and, through mechanisms such as enhancing cortical gamma oscillations, effectively activating disease-related microglia in the hippocampus, and promoting the clearance of β-amyloid plaques, provides a novel, non-genetic, implantable optical therapy strategy for neurodegenerative diseases.

This invention discloses a multi-objective generation system and method for implantable biodegradable hydrogel sustained-release carriers in the biomedical field. By constructing a systematic generation architecture that integrates material component gradient design, dynamic modeling of mechanical response, and closed-loop regulation of biocompatibility, and through the synergistic effect of a triple mechanism of molecular-level crosslinking network topology reconstruction, degradation kinetic parameter coupling optimization, and active adaptation of the interface microenvironment, the degradation rate, structural strength maintenance ability, and tissue integration performance of the hydrogel are simultaneously and precisely controlled during its in vivo service life. This overcomes the technical defects of existing technologies, such as premature softening failure or aggravated local inflammatory response caused by single-dimensional regulation. It realizes the gradient design of the internal structure of the hydrogel from macro to micro, enabling the material to autonomously adjust its stiffness distribution according to the local stress state when subjected to complex physiological loads, avoiding the sudden mechanical collapse caused by the overall degradation of traditional homogeneous hydrogels.

The covered stent comprises a metal stent and a covering film, the metal stent is composed of a spiral metal wire, the metal wire is provided with a plurality of zigzag portions which are evenly arranged and connected end to end, every two adjacent zigzag portions are in a wave crest shape and a wave trough shape respectively, the multiple zigzag portions enable the metal wire to be in a wave shape, and the covering film is arranged on the metal stent. The covering film covers the surface of the metal support to form a tubular structure, and the tubular structure can be kept shaped after bending deformation at the lesion position so that the tubular structure can be matched with the lesion position in shape. The covered stent disclosed by the utility model has a porous structure with high specific surface area and adjustable performance, the micron-sized aperture of the covered stent can effectively prevent blood permeation, the high porosity of the covered stent allows a proper amount of tissues or cells to penetrate, and vascularization and tissue integration of the implanted stent are promoted, so that the covered stent is helpful for reducing the risk of displacement or instability of the stent.

The invention belongs to the technical field of cartilage repair materials, and particularly relates to a repair material for promoting cartilage regeneration and a preparation method and application thereof. The invention discloses a complex for promoting cartilage regeneration. The complex comprises nerve cells capable of secreting chondroitin sulfate. According to the hydrogel-loaded nerve cell complex capable of secreting chondroitin sulfate, the cells are fixed through the three-dimensional scaffold effect of the hydrogel, the cartilage matrix microenvironment is simulated, mechanical support is provided for the defect, and the advantage that the nerve cells secrete chondroitin sulfate is combined; the problems of limited tissue source, low tissue integration degree, insufficient generation of transparent cartilage and the like in the existing cartilage repair technology are solved.

Polyurethane-based tissue fillers useful for treating and / or augmenting tissue, as well as acting as a biological scaffold that promotes cell in-ingrowth and tissue integration, are disclosed, as are quick-setting, injectable precursors of such tissue fillers. Such tissue fillers generally comprise (1) a polyurethane and (2) a particulate acellular tissue matrix. Also disclosed are methods of treating and / or augmenting tissues using such tissue fillers, particularly voids in human tissue such as anal fistulae or hernias.

The invention provides blood vessel promoting and antibacterial double-effect composite bone cement and a preparation method thereof, and belongs to the technical field of medical biological materials. The preparation method comprises the following steps: carrying out esterification reaction on methacrylic anhydride and hydroxyl of bacterial cellulose (BC) in anhydrous N, N-dimethylformamide to prepare modified cellulose (BC-MA) of which the surface contains methylacryloyl; the preparation method comprises the following steps: mixing BC-MA with an ethanol solution containing Roxadustat, and carrying out vacuum drying, so as to obtain a medicine carrying material BC-MA (at) Roxa; then spraying a high-concentration gentamicin sulfate aqueous solution on the BC-MA-coated Roxa, and carrying out freeze drying and grinding, so as to obtain a double-drug carrier BC-MA-coated Roxa-coated Genta; and mixing the powder with PMMA bone cement powder in proportion, adding a liquid-phase monomer, stirring and curing to obtain the BC-MA-coated Roxa-coated Genta / PMMA composite bone cement. The BC-MA (at) Roxa (at) Genta / PMMA composite bone cement prepared by the invention has relatively high porosity and connectivity, high drug loading capacity, stable release process and long duration time. The material realizes the functionalization of antibiosis and blood vessel promotion, and provides good biological activity and tissue integration performance for bone repair.

The application discloses a microneedle / GelMA hydrogel composite hernia patch and a preparation method thereof, the patch comprising a microneedle array layer and a GelMA hydrogel, the GelMA hydrogel covering and adhering to the root of the microneedle needle. The microneedle array layer is used for realizing tissue fixation and local drug delivery, the GelMA hydrogel is enzymatically crosslinked by an HRP / H2O2 system to form a stable structure, and has good flexibility and wet adhesion performance. The application combines the biodegradability and tissue integration characteristics of type IV collagen and the adjustable mechanics and biological adhesion characteristics of the GelMA hydrogel, realizes a minimally invasive, stable and degradable hernia repair scheme, can be firmly attached to the tissue surface without suturing, can be gradually degraded and absorbed after the operation, reduces foreign body reaction and organ adhesion, significantly reduces the risk of infection and recurrence, and has excellent biocompatibility and clinical application prospect.