22 results about "Cerebral paralysis" patented technology

The invention discloses a curcumin-loaded brain-targeted drug delivery system as well as a preparation method and application thereof. The delivery system comprises a carrier macrophage and a curcumin drug, the curcumin nano-drug is prepared by encapsulating curcumin with a lipoic acid modified cyclodextrin conjugate, then macrophages and the curcumin nano-drug are mixed, and co-incubation is carried out, so that the curcumin nano-drug is constructed. The brain-targeted macrophage drug delivery system loaded with curcumin is a multifunctional composite drug with brain targeting property for treatment of cerebral arterial thrombosis. A brain-targeted macrophage drug delivery system loaded with the curcumin nano-drug gathers in cerebral apoplexy tissues, phenotypic transformation of inflammatory microglial cells is promoted, and a pro-inflammatory microenvironment is improved; the oxidative stress pressure of the stroke part is improved; the two effects promote each other, the stroke microenvironment is improved, the functions of neuronal cells are saved, the synergistic nerve protection effect can be achieved in the aspect of treating ischemic cerebral apoplexy, and potential safety hazards are reduced.

The present invention discloses the application of Chinese medicine Polygonum aviculare in the preparation of drugs for preventing and treating stroke. It relates to the field of biomedicine technology. The present invention shows that Chinese medicine Polygonum aviculare can significantly reduce the brain water content and brain index of experimental animals, and can treat brain edema. The drug has the effects of promoting blood circulation and removing blood stasis, can eliminate cerebral vascular blockage and inflammation, resist cerebral vasospasm, maintain normal cerebral vascular function, regulate normal permeability of brain barrier, promote angiogenesis, promote brain nerve function repair and regeneration, and greatly restore the nerve damage and behavioral ability of patients with cerebral stroke. Chinese medicine Polygonum aviculare can be dialectically used for the prevention and treatment of various courses of ischemic stroke and hemorrhagic stroke. The present invention not only provides a new application of Chinese medicine Polygonum aviculare, but also provides a new drug for preventing and treating ischemic stroke and hemorrhagic stroke.

The present invention relates to an image segmentation method and apparatus based on a U-shaped twin network. The method includes: obtaining a target image to be segmented, where the target image is a chronic stroke imaging image; constructing and training a segmentation model based on the morphological structure of brain tissue and machine learning, and using the trained segmentation model to segment the brain tissue region of the target image; using the trained deep twin network to segment the lesions of the target image after the brain tissue region is segmented. The present invention processes the lesion image in stages through a deep twin network model and machine learning, and uses the difference between normal images and lesion images in the morphology of brain tissue as features to train the recognition model, thereby improving the robustness and accuracy of the recognition model.

The invention discloses application of a PLAU signal channel inhibitor in treating ischemic cerebral apoplexy and a pharmaceutical composition, and belongs to the field of biological medicine. The PLAU signal channel inhibitor inhibits the activation of an NF-kappa B channel and reduces the generation of inflammatory factors (IL-1beta, IL-6 and TNF-alpha) by inhibiting the expression of PLAU protein in cells. Experiments prove that the PLAU signal channel inhibitor can remarkably improve related pathological indexes of ischemic cerebral apoplexy, the cerebral infarction area is reduced by more than or equal to 30%, the vascular endothelial cell activity is improved by more than or equal to 25%, the inflammatory factor level is reduced by more than or equal to 40%, and the protective effect on cerebral ischemia reperfusion injury is superior to the overall effect of a traditional Chinese medicine compound. The invention provides a clear mechanism basis for targeted therapy of ischemic cerebral apoplexy.

The invention discloses an experimental method for relieving ferroptosis of cerebral apoplexy rats through tVNS, and relates to the technical field of nerve regulation and control. Comprising the following steps: S1, constructing a rat MCAO model, and constructing an SD rat right cerebral ischemia reperfusion model by adopting a suture method; s2, experiment grouping: randomly dividing experimental animals into (1) a false operation group: an SHAM group; (2) a cerebral ischemia reperfusion group: an MCAO group; (3) an ear vagus nerve electrical stimulation group after cerebral ischemia reperfusion: a tVNS group; and S3, performing ear vagus nerve electrical stimulation intervention. Ferroptosis related proteins such as GPX4, ACSL4 and FTH1 are detected through Western blot, it is proved that tVNS can improve stroke rat brain tissue ferroptosis, and clear molecular mechanism support is provided for intervention; the content of reduced glutathione and the content of malondialdehyde are respectively detected by using a GSH and MDA content detection kit, and the effectiveness of tVNS in the aspect of relieving ferroptosis is further verified.

The application provides a cerebral apoplexy postoperative sign monitoring system, which is fused with a nerve motor function evaluation wristband and a head-mounted brain electrical impedance dynamic imaging device, and breaks through the blind area of postoperative monitoring. The wristband device collects upper limb electromyographic signals and joint motion mechanics parameters through a microneedle electrode array and a distributed piezoresistive sensor, drives a neural network to output a standardized motor score based on time-frequency domain features containing electromyography, joint angle, trajectory smoothness and grip force change rate, and is related to a clinical Fugl-Meyer scale; the imaging device adopts a multi-ring electrode array and an improved D-bar algorithm to reconstruct a brain electrical conductivity distribution map, constructs a multi-level decision tree early warning model by extracting impedance change rate Delta Z, spatial gradient entropy SGE and hemisphere asymmetry Asym, and realizes brain edema detection. Through multi-modal data fusion and minute-level response, the system solves the fragmentation problem of postoperative monitoring and provides precise decision support for cerebral apoplexy rehabilitation.

The present invention discloses a device and method for monitoring cerebral stroke based on non-contact electrical impedance imaging and current focusing. The device is composed of a non-contact current focusing sensor, an electrode switching module, a data acquisition module and an image reconstruction host computer. The non-contact current focusing sensor includes a focusing electrode layer, a detection electrode layer and two insulating layers. Among them, the focusing electrode is used to achieve a current focusing effect, thereby improving the detection depth and sensitivity of the signal; the detection electrode is responsible for obtaining the detection current containing brain electrical impedance information. The image reconstruction host computer is used to achieve image reconstruction and obtain real-time images and quantitative parameters of cerebral stroke. The present invention has the advantages of being non-contact, wearable, safe and friendly, highly sensitive, low cost, and having a fast imaging speed. It is suitable for scenarios such as homes, clinics, ambulances, etc. that require rapid diagnosis or real-time monitoring and are not covered by equipment such as CT / MRI, and avoids the measurement requirements of existing electrical impedance imaging equipment where patients need to shave their heads or implant electrodes.

The present invention relates to a C-17 carbonyl-substituted oleanane triterpene derivative, a preparation method therefor, and a use thereof. Provided are a C-17 carbonyl-substituted oleanane triterpene derivative, a use of the compound in the preparation of an NRF2 activator, and preparation of a medicament for treating / preventing diseases. The diseases comprise cerebral small vascular disease, mitochondrial encephalomyopathy, autism spectrum disorder, Rett syndrome, Friedreich ataxia, stroke, hemorrhagic cerebral apoplexy, ischemic cerebral apoplexy, multiple sclerosis, amyotrophic lateral sclerosis, schizophrenia, schizophrenic cognitive impairment, Parkinson's disease, cognitive impairment in Parkinson's disease, Alzheimer's disease, vascular dementia, epilepsy, Huntington's disease, heart failure, myocardial infarction, renal failure, kidney ischemia, etc., or other disease states and conditions which are obvious to a person skilled in the art. Also provided are a prodrug thereof, or a pharmaceutically acceptable salt thereof, or a hydrate or solvate thereof, and a pharmaceutical composition containing same.

Disclosed are devices, systems and methods for non-invasive neuromodulation system for prompt treatment of cerebral and / or ocular strokes caused by acute dysregulated reduced cerebral blood flow (CBF) and / or ocular blood flow (OBF) by up regulation of trigeminovascular system (TVS), and trigeminal autonomic brain reflexes (TABRs) through stimulation of ophthalmic nerve. Additionally or alternatively, the subject's sympathetic nervous system (SNS) is down regulated centrally by intravenous administration of pharmacological dose of ascorbic acid. The site of stimulation of ophthalmic nerve includes but not limited to nasal vestibule, nasal bridge, and forehead and upper eyelid. In some embodiments, the devices are handheld, portable with nose supported, having one or more intra-nasal or extra-nasal application heads. The signal can include vibration, chemical, ultrasonic, optical, electrical, hybrid electro-optical or combination of two or more of these types of stimuli. The subject's TVS and autonomic nervous system (ANS) are modulated in a manner that is effective to treat the subject for cerebral and ocular strokes. The invention, in some embodiments thereof, relates to a method for decreasing vascular resistance, enhancing vasodilatation in cerebral arteries, leptomeningeal collaterals and ophthalmic artery by the release of Vasoactive intestinal peptide (VIP), substance P and CGRP thereof increasing cerebral and / or OBF to the brain and the eye in subject's with acute dysregulated, reduced cerebral and / or OBF. The invention, in some embodiments thereof, is also relates to upregulation of TVS in a manner that is effective to induce acute development of leptomeningeal collateral circulation sufficient to ameliorate the ischemic effect of occluded cerebral artery, enhances successful recanalization, decreases the infarction volume and improves brain functional recovery without hemorrhagic transformation. In some embodiments TVS and ANS are also modulated in a manner that induce an acute increase in choroidal blood flow sufficient to ameliorate the ischemic effect of occluded artery until spontaneous recanalization of the occluded artery is accomplished. The invention is related to targeting the affected side via ipsilateral ONS without inducing intracerebral vascular steal phenomenon. The invention, in some embodiments thereof, is also relates to the methods for improving delivery of oxygen, glucose, anticoagulants, hormones, humoral mediators, growth factors and pharmacological agents to the targeted ischemic tissues of the brain, retina and optic nerve. The methods of the invention, when combined with r-tPA treatment and / or endovascular recanalization increases window time of treatment of stroke, enhance the efficacy of treatment and reduce its side effects. The methods of the invention, in some embodiments thereof, include priming of the brain, retina and / or optic nerve thereof to enhance the efficacy of cell transplantation therapy after exposure to stroke. Methods of the invention, in some embodiments thereof, may also include monitoring the subject for prophylactic treatment. The cerebral / and or OBF of subjects who had received neuromodulation treatment may also be monitored for re-treatment.

A pharmaceutical formulation for treatment of cerebral stroke includes an endothelin-B receptor analog in a dosing range of 0.00001 mg / kg−1 mg / kg, and a drug in a dosing range of 0.0015 g / kg-5 g / kg, wherein endothelin-B receptor analog includes, but not limited to sovateltide, BQ-3020, [Ala1,3,11,15]-endothelin, sarafotoxin S6c, endothelin-3, and the drug includes, but not limited to mannitol and citicoline.

The invention belongs to the technical field of medical nursing instruments. The invention discloses a cerebral apoplexy paralyzed patient transfer instrument. The cerebral apoplexy paralyzed patient transfer instrument comprises a base with walking wheels, wherein a pushing frame is arranged at the top of one side of the base; longitudinal sleeves are movably arranged on the two sides of the pushing frame in a sleeving mode, and each longitudinal sleeve is connected with a synchronous regulator arranged on the base. The longitudinal sleeve is further provided with a sitting and leaning structure which is used for supporting a patient to sit and lean so that off-bed transfer operation can be conveniently carried out. The monitoring structure is used for monitoring the sitting and leaning state of the patient and the connecting stability of the guardrail components of the sitting and leaning structure. The device has the advantages that accidental injuries to the cerebral apoplexy paralyzed patient in the position transferring process can be reduced, and the body burden and labor intensity of medical staff are relieved.

The present invention relates to the technical field of pharmaceutical compositions, and in particular to a Chinese medicine composition for treating cerebral stroke and a preparation method thereof. The present invention provides a Chinese medicine composition for treating cerebral stroke, which is prepared from the following components by mass: 20 to 26 parts of Gastrodia elata, 12 to 16 parts of Scolopendra subspinipes, 8 to 12 parts of Hawksbill turtle, 14 to 18 parts of Angelica sinensis, 10 to 16 parts of Millettia reticulata, 7 to 13 parts of Red Peony Root, 8 to 12 parts of Forsythia suspensa, 8 to 12 parts of Periostracum Cicadae, 6 to 10 parts of Radix Rehmanniae, 7 to 11 parts of Poria cocos, 7 to 11 parts of Eclipta prostrata, 4 to 8 parts of Semen Platycladi, and 3 to 7 parts of Polygala tenuifolia. The Chinese medicine composition for treating cerebral stroke provided by the present invention has excellent technical effects for treating cerebral stroke, quick effect, no recurrence after cure, and no toxic and side effects. It also has the effects of improving brain blood supply and promoting nerve function repair, and the therapeutic effect is equivalent to that of existing drugs.

The invention belongs to the technical field of medical instruments, and particularly relates to a rehabilitation training device for cerebral apoplexy patients, which comprises a plate body. The movable plate unfolding or folding unit is matched with a stepping motor through gear transmission, stable unfolding and compact folding of the movable plate are achieved, the height of the device can be flexibly adjusted according to the height of a patient in cooperation with a gear and rack driving structure of the walking aid leg telescopic unit, and the use requirements of patients of different body types are met; the height can be shortened and a movable plate can be folded when the device is not used, the occupied space is greatly reduced, the problem that a traditional device is inconvenient to store is solved, the anti-falling unit forms front side supporting buffering when the gravity center of a patient shifts through the arc-shaped sliding design of a semi-ring-shaped plate, and falling accidents are effectively avoided; meanwhile, the positioner transmits position information in real time, the beeper facilitates emergency call, double safety guarantees are provided for training of the patient, in addition, the seat plate pop-up unit achieves flexible stretching and retracting of the seat plate through transmission of a lead screw and a sliding rod, and the temporary rest requirement of the patient is met.

The cerebral apoplexy rehabilitation dietary therapy meal is prepared from the following raw materials in parts by weight: 90 to 110 parts of red dates, 15 to 25 parts of radix angelicae sinensis, 23 to 27 parts of radix rehmanniae preparata, 22 to 27 parts of fructus lycii, 23 to 26 parts of hyacinth beans, 21 to 28 parts of rhizoma imperatae, 49 to 51 parts of black sesame seeds and 225 to 235 parts of oat. The preparation method of the cerebral apoplexy rehabilitation dietary therapy meal comprises the steps of selection and cleaning, drying, stir-frying, grinding and finished product treatment. According to the cerebral apoplexy rehabilitation dietary therapy meal, various traditional Chinese medicinal materials and food materials are scientifically proportioned, so that the health-care effects of all the components can be comprehensively exerted, and the physical condition of a cerebral apoplexy patient can be assisted to be improved; the preparation method is simple and feasible, easily available in raw materials and suitable for homemade or industrial production; meanwhile, the finished product is easy to store and convenient to carry and is convenient for long-term taking.

According to the post-stroke-operation sign monitoring system, the neural motor function evaluation wrist strap and the head-mounted electroencephalogram impedance dynamic imaging device are fused, and the post-operation monitoring blind area is broken through. The wrist strap device collects upper limb electromyographic signals and joint movement mechanical parameters through a microneedle electrode array and a distributed piezoresistive sensor, a neural network is driven to output standardized movement scores based on electromyographic time-frequency domain features, joint angles, track smoothness and grip strength change rates, and the standardized movement scores are related to a clinical Fugl-Meyer scale. According to the imaging device, a multi-ring electrode array and an improved D-bar algorithm are adopted to reconstruct an electroencephalogram conductivity distribution diagram, a multi-level decision tree early warning model is constructed by extracting the impedance change rate delta Z, the spatial gradient entropy SGE and the hemisphere asymmetry degree Asym, encephaledema detection is achieved, the system solves the problem of postoperative monitoring fragmentation through multi-modal data fusion and minute-level response, and the system has the advantages of being high in reliability and high in reliability. And accurate decision support is provided for cerebral apoplexy rehabilitation.

According to the intelligent physical sign monitoring device and the monitoring method thereof, the optical fiber sensing technology and the artificial intelligence algorithm are adopted, key physiological indexes such as the sleep state, the respiratory rate, the heart rate, the blood pressure, the blood oxygen and the variability of a user can be accurately monitored without any physical contact, comprehensive and accurate physiological index monitoring and data insight are provided for the user, and the user experience is improved. And a new era for early warning the occurrence of serious diseases such as heart diseases and cerebral apoplexy caused by various factors and monitoring the sleep process and psychological tension is started.

The utility model discloses a kind of extracorporeal circulation systems, it is related to medical instrument technical field.Extracorporeal circulation system includes the inflow pipe, handle and outflow pipe connected in turn, inflow pipe is used to connect carotid artery, outflow pipe is used to connect vein;Handle includes shell and the flow through switch, flow through regulator and blood filter being set in shell.In application when inflow pipe is connected into carotid artery, outflow pipe is connected into vein, high-pressure arterial blood flow and low-pressure venous blood flow form pressure difference, make the blood flow of carotid artery reverse flow to vein, establish the blood retrograde passage from carotid artery to vein, can be opened and closed above-mentioned retrograde passage by flow through switch, utilize flow through regulator to adjust the flow rate and flow of blood flow, and utilize blood filter to intercept thrombus and other accumulations falling in interventional operation, reduce the problem that thrombus and other accumulations enter brain with blood and cause cerebral apoplexy or embolism.

Provided is an application of a circular RNA in the preparation of a cerebral stroke diagnosis product, belonging to the field of circular RNA medical treatments. Provided is a kit, comprising a reagent and / or test paper and / or gene chip for detecting a circular RNA-circ-Magi1 . The nucleotide sequence of the circular RNA-circ-Magi1 is as shown in SEQ ID NO: 1 or SEQ ID NO: 4. Further provided is the application of a detection system for the diagnosis, assisted diagnosis or prognosis evaluation of cerebral stroke, and a detection reagent of the circular RNA-circ-Magi1 in the preparation of a kit, test paper, chip or high-throughput sequencing platform for the diagnosis, assisted diagnosis or prognosis evaluation of cerebral stroke.

The invention relates to the technical field of conveying devices, in particular to a pig conveying device for slaughtering, which comprises a placing frame and a bearing frame, one end of the placing frame is fixedly communicated with one end of the bearing frame, and connecting strips are arranged on two sides of the other end of the placing frame. Limiting barrier strips are hinged to the adjacent sides of the two connecting strips, limiting pins are jointly inserted into the adjacent ends of the two limiting barrier strips in a sliding mode, and transverse displacement mechanisms are connected to the connecting strips. Movement of the live pigs is limited in a supporting mode, tension of the live pigs caused by binding constraint can be eliminated, then the heads of the live pigs are electrically shocked, the live pigs are instantly paralyzed in heart and brain and coma, pains generated when the live pigs are slaughtered are reduced, and animal welfare improvement is facilitated.

The invention discloses a research method for improving a cerebral apoplexy neuroinflammation mechanism through vagus nerve electrical stimulation, and relates to the field of medicine. Comprising the following steps: constructing an SD rat MCAO / R model by adopting a suture method, and incorporating the model into an experiment according to a Longa-Z score of 1-3; the method comprises the following steps: dividing rats into three groups, namely a false operation SHAM group, a cerebral ischemia reperfusion MCAO / R group and a cerebral ischemia reperfusion vagus nerve electrical stimulation MCAO + VNS group; vagus nerve electrical stimulation VNS intervention: after ischemia is carried out for 30 min, the left vagus nerve is stimulated. VNS-Dectin1 mechanism association is disclosed for the first time, Western blot and immunofluorescence co-localization prove that VNS significantly reduces the protein expression of brain tissue Dectin1 and reduces co-localization of Dectin1 and IBA1 + microglial cells, and it is clear that VNS regulates activation of microglial cells by inhibiting a Dectin1 receptor.

The invention relates to a medicine for treating cerebral apoplexy nerve recovery and a preparation method thereof, and belongs to the technical field of medicines. The American ginseng fruit total saponins are derived from American ginseng pulp, the mass percentage content of saponins in the total saponins is 55%-65%, and according to the application of the American ginseng fruit total saponins in preparing the cerebral apoplexy nerve recovery medicine for treating an object, the cerebral infarction volume of the object is reduced, nerve function damage is relieved, and the cerebral apoplexy nerve recovery effect is improved. The nerve protection and repair effects on cerebral apoplexy are realized. The American ginseng fruit total saponin has the advantages that the American ginseng fruit total saponin can obviously reduce the cerebral infarction volume of cerebral apoplexy mice, recover the sensory and motor functions of the mice, reduce neurological function impairment, improve the abnormal change of the tissue pathological morphology of the mice, reduce neuroinflammation and oxidative stress levels of the mice, promote the neural recovery of the cerebral apoplexy mice, and improve the cerebral apoplexy effect of the mice. And solid material basis and experimental basis are provided for developing innovative traditional Chinese medicines or natural medicines for treating cerebral apoplexy.

The invention discloses a traditional Chinese medicine composition for promoting neuron regeneration. Relates to the technical field. Comprising ginseng flowers, sanchi flowers, gastrodia elata, earthworms and nervonic acid. The traditional Chinese medicine composition can repair and dredge a nerve fiber network, activate nerve cells, recover the coordination function of the brain, eliminate sequelae such as hemiplegia, numbness of limbs and unclear speech caused by cerebral apoplexy, and realize autonomous behavior ability and life self-care.