176 results about "Cerebral paralysis" patented technology

The invention discloses a wearable hand function rehabilitation robot, which is mainly used for assisting the repeated movement function rehabilitation training of the patient with hand movement function disorder which is caused by stroke, brain trauma, spinal cord injury and peripheral nerve injury in communities or families. The robot system extracts the active movement will of the patient by detecting the multi-channel surface myoelectric signals of the affected hand and obtains the state of the affected limb by combining the data which is measured by an angle and force sensor to carry out the rehabilitation training of the affected hand by pneumatic muscle contraction assistance by using the intelligent control algorithm on the basis. The rehabilitation robot has multiple degrees of freedom, which can assist the affected hand to carry out multi-joint complex movement and inosculate the multi-sensor data information fusion during the rehabilitation process to be further used for the evaluation of rehabilitation effect, and the activity and the training interest of the patient can be improved by using the rehabilitation treatment virtual environment on a computer. The invention has the advantages of simple structure, flexible movement, safety and reliability, which can not only realize the rehabilitation training of the movement function of the affected hand, but can also be in line with the physiologic structure characteristics of human hands. The invention is more comfortable to wear.

Disclosed are methods and related devices for use with subjects with cerebral palsy or periventricular leukomalacia. In preferred embodiments, diffusion tensor imaging (DTI) is used to identify neural areas and transcranial magnetic stimulation (TMS) is used to stimulate neural pathways.

The invention discloses a cerebral palsy child rehabilitation training method based on a Kinect sensor. The method comprises the following steps: S1, acquiring skeleton point data of a child; S2, carrying out limb movement training and judging the tilting angle and uplifting angle of skeleton points of the child, wherein after the child conducts a movement, the movement of the child is captured, and the tilting angle and uplifting angle of the joint points of the head, the upper limbs and the lower limbs are judged; S3, carrying out robust interactive processing on the movement of the child; S4, connecting a game engine and sending child skeleton data obtained after robust interactive processing in the step S3 to the game engine; S5, feeding back the movement of the child in a voice mode to remind the child of non-standard movements and encourage the child to conduct standard movements; S6, estimating the progress of rehabilitation training of the child. According to the method, the movement behavior characteristics of the child in training are acquired based on microsoft Kinect, so that the cardiovascular endurance, muscular endurance, muscular force, balance and flexibility of the child are comprehensively developed.

The invention provides a measuring system for sitting-posture spine correction of cerebral palsy patients, comprising a sitting-posture spine correction brace simulation part and a pressure measurement part, wherein the sitting-posture spine correction brace simulation part simulates the force applying way of the spine correction brace and simulates the spine correction effect of the spine correction brace on the cerebral palsy patients via the effect of the applied force; and the pressure measurement part realizes measurement of the distributed pressures of the corrected parts and the hip and carries out analysis and evaluation to provide mechanical basis for designing the personalized sitting-posture spine correction brace for cerebral palsy patients. The system can simulate the correction function of the sitting-posture spine correction brace for cerebral palsy patients, measure the distributed pressures of the correct parts and the hip, realize quantitative biomechanics measurement analysis of sitting-posture spine correction of the cerebral palsy patients and provide mechanical basis for designing the personalized sitting-posture spine correction brace for cerebral palsy patients.

The invention discloses an auxiliary training tool for comprehensive rehabilitation of cerebral palsy. The auxiliary training tool comprises a chassis, a lower limb exoskeleton device and a suspension device, wherein the chassis comprises universal casters with the locking function, a lower chassis, an upper chassis and an exoskeleton device inclination adjusting mechanism; the lower limb exoskeleton device is fixedly mounted on the chassis, and can realize rehabilitation training such as flexion / extension, adduction / abduction and pronation / supination of hip joints, flexion / extension of the knee joint, and dorsi-flexion / plantar-flexion, strephenopodia / strephexopodia and pronation ans supination of feet; the suspension device is fixedly mounted on the chassis, and plays a role in slinging, weight reduction and upper body posture correction of paitents. The auxiliary training tool can help patients with cerebral palsy to correct the abnormal posture of lower limbs, carry out the rehabilitation training on all joints of the lower limbs, promotes the development of all the joints of the lower limbs, and gradually establishes the normal standing and walking functions.

The invention discloses an intravascular stent of a composite structure; the intravascular stent comprises a stent main body, wherein the distal end of the stent is restrained as an adducted form by virtue of a tightening wire, and the tightening wire is degradable magnesium alloy or degradable iron alloy; one or more auxiliary wires are woven on the stent main body; when the stent is applied to blood vessel of brain, the auxiliary wire is pure platinum or alloy thereof, pure gold or alloy thereof, pure tungsten or alloy thereof, or pure tantalum or alloy thereof; and when the stent is applied to peripheral blood vessel, the auxiliary wire is cobalt-chromium alloy or stainless steel or tungsten or tantalum. The stent, when serving as a thrombus removal system for treating cerebral apoplexy, not only can be used for removing thrombus effectively for several times but also can be used for catching small thrombus flowing to distal end so as to prevent distal blood vessels from getting blocked; and the stent can be used for dilating stenosis or blocked brain blood vessel or peripheral blood vessel, so as to take an effect of dredging and reconstructing a blood flow. The stent can be repositioned and released, with high controllability; and the stent can be used for reducing operation difficulty and greatly improving an operation success rate.

The invention discloses a process for preparing hirudin by using blood- suction leeches, as well as its use, the preparing process consists of pulping leeches, formulating suspension and drying. The substance can be prepared into capsules, soft capsules, granules and tablets. The obtained medicament can be used for treating cardiovascular and cerebrovascular diseases including cerebral apoplexy, hypertension, hyperlipemia and coronary disease.

The invention discloses an ICU ward horizontal-type bilateral cerebral palsy lower limb rehabilitation robot with the functions of communication and autonomous navigation movement. The robot structurally comprises a lower limb rehabilitation exoskeleton, a human body sign data collection module, a data processing module, a human-computer interaction module, a motion control module and an autonomous navigation moving chassis, and evaluation and coordinated rehabilitation training on all joints of the two lower limbs can be achieved; the data collection module collects motion and physiological data of the joints of the lower limbs and sends the data to the data processing module, the data processing module gives out a rehabilitation evaluation result of a patient and related motion data anduploads the result and the data to a cloud platform, and the cloud platform generates a personalized treatment scheme through clustering analysis; the human-computer interaction module sends an instruction to the motion control module to control the lower limb exoskeleton and guide the patient in rehabilitation training; the autonomous navigation moving chassis adopts Mecanum wheel design, indoorand outdoor navigation is achieved through the combination of GPS, vision and laser navigation, obstacle avoidance is achieved through ultrasonic detection, and the autonomous moving capability of therobot is improved.

The invention provides a cerebral alpha wave feedback regulation acupoint magnetic stimulation system. The system consists of a magnetic stimulation generating instrument, an electroencephalograph and a computer. According to the system, a trumpet-shaped stimulation coil of the magnetic stimulation generating instrument is fixed on an acupuncture point of a human body to magnetically stimulate, the electroencephalograph is used for acquiring electroencephalograms, and the electroencephalogram data processing computer analyzes the power spectrum of a cerebral alpha wave and computes the energy of the cerebral alpha wave, draws and displays a dynamic brain electrical activity mapping; and the stimulation intensity, stimulation frequency and stimulation waveform are respectively and automatically regulated in a feedback manner and manually regulated according to the energy of the electroencephalogram cerebral alpha wave and the dynamic brain electrical activity mapping so as to obtain an optimum acupoint stimulation effect. The system can promote the nervous system recovery of cerebral palsy patients and the autonomous rehabilitation training of acroparalysis patients.

The invention discloses a PEGylated scutellarin compound and a preparation method thereof. The PEGylated scutellarin compound is as the shown formula (IV) and the PEGylated scutellarin compound can be applied to preparing medicaments applied to treating cerebral thrombosis, cerebral infarction, cerebral apoplexy, sequelaes caused by cerebral apoplexy, coronary heart disease or angina. Compared with the original scutellarin compound, the water solubility of the scutellarin compound is increased obviously; simultaneously, pharmacodynamics experiment on the mice model of cerebral ischemia-reperfusion shows that: compared with the original medicament, the biological activity of the scutellarin promedicament is strengthened obviously.

The invention discloses a system for coordinate motor rehabilitation of both lower limbs of cerebral palsy patient in an intensive care room. The system comprises a lower limb rehabilitation trainingmachine, a motion control module, an interactive control module, a data acquisition module and a cloud platform. The data acquisition module collects the physical sign data of ICU patients with cerebral palsy, and transmits them to the interactive control module through serial communication, so as to realize the evaluation and safety control of the coordinated movement of both lower limbs of ICU patients with cerebral palsy. According to the evaluation results, the rehabilitation training program can be generated automatically, and the doctors and nurses can also set the rehabilitation training mode and parameters through the interactive control module to generate control instructions, which are sent to the motion control module to control the lower limb rehabilitation training machine toassist the patient to complete the multi-mode rehabilitation training, and the lower limb rehabilitation training machine can help the patient complete the multi-mode rehabilitation training. Cloud platform is connected with hospital medical record management system through Internet, and ICU patients' medical record information and physical sign data are imported. Cluster analysis is used to generate personalized rehabilitation treatment scheme automatically. The system can also move freely and adjust the position according to the patients' needs. The system is easy to operate, safe and reliable, and has a broad application prospect.

An alkyl ether derivative represented by the formula: wherein R1, R2, R3, R4, m and n are as defined in the specification, or salts thereof exhibits synergistically improved anti-hypoxic activity when combined with a compound having an acetylcholine esterase inhibitory activity. Therefore, the combination according to the present invention is useful as a method for improving cerebral function. Further, a pharmaceutical composition containing the compound relating to the combination according to the present invention is useful for treatment and prevention of dysfunction of cerebral acetylcholine neurons in the sequelae of cerebrovascular dementia, senile dementia, Alzheimer's disease and ischemic cerebral lesion and in the cerebral apoplexy or the memory impairment caused by selective neuronal death.

The invention relates to a pyrazine derivative which has a structure shown in a general formula I, and also discloses a synthesis method of the pyrazine derivative. The compound has an anti-oxidation effect and a thrombolysis effect, can be used for treating cerebral apoplexy caused by ischemia and can also be used for preparing medicaments for treating nerve system diseases, infectious diseases, metabolic system diseases, cardiac-cerebral vascular system diseases, degenerative aging diseases and the like caused by excess production of free radical and / or thrombosis.

The present invention provides one kind of total paeonoside extract and its preparation process as well as the application of the total paeonoside extract in preparing medicine for preventing and treating cardiac and cerebral vascular diseases. Specifically, the total paeonoside extract is used in preparing medicine for preventing and treating cerebral apoplexy, cerebral ischemia / re-perfusion damabe, brain trauma, senile dementia, etc.

An alkyl ether derivative represented by the formula:wherein R1, R2, R3, R4, m and n are as defined in the specification, or salts thereof exhibits synergistically improved anti-hypoxic activity when combined with a compound having an acetylcholine esterase inhibitory activity. Therefore, the combination according to the present invention is useful as a method for improving cerebral function. Further, a pharmaceutical composition containing the compound relating to the combination according to the present invention is useful for treatment and prevention of dysfunction of cerebral acetylcholine neurons in the sequelae of cerebrovascular dementia, senile dementia, Alzheimer's disease and ischemic cerebral lesion and in the cerebral apoplexy or the memory impairment caused by selective neuronal death.

The invention discloses a rehabilitation walker for children with cerebral palsy. The rehabilitation walker comprises a length-adjustable bottom frame of which the front is opened in an arch shape andextending from the middle to the rear, universal carrying wheels arranged on the lower portion of the bottom frame, a front vertical rod hinged with the bottom frame, a rear vertical rod fixedly connected with the bottom frame, a linear actuator hinged with the front vertical rod and the rear vertical rod separately, two armrest arms fixedly arranged on the front vertical rod separately and a shock absorber fixedly arranged on the rear vertical rod, wherein the armrest arms are arc-shaped bent elbows, the upper portion of the rear vertical rod is fixedly provided with a crotch supporting seat, and the rear of the crotch supporting seat is fixedly provided with a backrest. The rehabilitation walker for the children with the cerebral palsy has the advantages that the structure is simple, the balance can be kept well, the good balance can be provided for the children with the cerebral palsy so that a patient can complete coordinated movements such as walking upright, walking and weight loss walking, ensure the relative activity of the limbs, enhance the muscle force of the upper and lower limbs and prevent muscle atrophy.

The present invention provides application of Danshensu in preparation of medicine for treating cerebrovascular diseases, concretely relates to application of Danshensu in preparation of medicine for treating ischemic stroke, application of Danshensu in preparation of medicine for treating NMDA receptor derivation neurons in the brain damage, application of Danshensu in preparation of medicine for treating brain trauma. The invention also provides medicine composition containing Danshensu for treating cerebrovascular diseases, whose unit dose is 50-200mg.

The invention relates to a traditional Chinese pharmaceutical preparation for treating cerebrovascular diseases and process for preparation, wherein the preparation substantially comprises codonopsis pilosula, notoginseng, leeches and rheum officinale, the weight portion of the compositions are, codonopsis pilosula 39%-53%, notoginseng 17%-29%, leeches 17%-27%, rhubarb 8%-18%.

The invention provides a walking correction training instrument, a manufacturing method and a walking correction training method. A trunk positioning regulating platform is installed at the upper end of a main supporting frame, a chest correction assembly, a belly correction assembly and a walking console bracket are installed on one side of the trunk positioning regulating platform, a hip correction assembly, a back correction assembly and a master controller are installed on the other side of the trunk positioning regulating platform, and a space for human body in-position correction training is formed. The walking correction training instrument is reasonable in design, compact in structure, small in occupied space, simple in operation, easy to master, convenient to install and maintain, significant in correction training effect, and reliable in safety in training of a patient, the body of the patient in training is not injured, the chest, belly, hips, back and ankles in dynamic training are reasonably limited in a normal moving range, the patient can be in the optimum training state all the time in a training process, rehabilitation efficacy for common brain paralysis patients, trauma sequela patients, stroke sequela patients, patients with limb muscle weakness reduction caused by cerebral hemorrhage, patients with physical handicaps and patients with bad walking postures are achieved, and the instrument is suitable for being used in hospitals, rehabilitation centers and families.

The invention relates to the field of medicaments, and in particular relates to a 3H-1,2-dithio-cyclopentene-3-thioketone compound and an application thereof. The 3H-1,2-dithio-cyclopentene-3-thioketone compound disclosed by the invention has a structure shown in a formula I or a formula II and is a compound with a completely-new structure. Proved by experiments, the 3H-1,2-dithio-cyclopentene-3-thioketone compound has a direct protection role on neurons on a cell model, and can obviously restrain excessive inflammatory responses of inflammatory cells in the cerebrum; and by using 3H-1,2-dithio-cyclopentene-3-thioketone, focal cerebral ischemia cerebral infarction volume of a mouse can be obviously reduced in an animal model. Therefore, the invention provides the 3H-1,2-dithio-cyclopentene-3-thioketone compound and the application of acceptable slat of the 3H-1,2-dithio-cyclopentene-3-thioketone compound on the pharmacy aspect to the preparation of medicaments for preventing or treating a cerebral apoplexy disease.

The present invention belongs to a Chinese traditional medicine preparation in medical preparation product for curing sequela of cerebral paralysis; the preparation is made of the following raw materials of Chinese traditional medicines with corresponding weight portions of 6 portion to 12 portion of zhinanxing, 6 portion to 12 portion of pinellia tuber, 4 portion to 8 portion of giant typhonium tuber, 10 portion to 20 portion of chuanxiong rhizome, 6 portion to 12 portion of body of Buthus martensii, 15 portion to 25 portion of earthworm, 10 portion to 20 portion of tall gastrodia tuber, 15 portion to 25 portion of clematis, 10 portion to 20 portion of white caltrop, 40 portion to 60 portion of milk vetch roots, 10 portion to 20 portion of magnolia officinalis, 15 portion to 25 portion of trifoliate orange fruit, 15 portion to 25 portion of roots of red salvia, 10 portion to 20 portion of flagleaf, 15 portion to 25 portion of Tuckahoe, 15 portion to 25 portion of milkwort roots, 15 portion to 25 portion of codonopsis pilosula, 5 portion to 7 portion of safflowers, 10 portion to 20 portion of ledeboruiella root, 10 portion to 20 portion of myrrh, 7 portion to 11 portion of gynura segetum and 15 portion to 20 portion of sapanwood. The present invention of the preparation contains active components which can stimulate the impaired brain cells and recover the function of the cells through blood-brain barrier; at the same time, the preparation can repair the impaired nerves and recover the impaired blood-brain barrier to protect the brain tissue and improve the nerve function of patients; the preparation can promote the absorption of encephalic hematoma and reduce the disability rate; in this way, people can recover normal living and working capability and the present invention is a good medicine for curing sequela of cerebral paralysis.

A system and method for measuring the movement of one or more limbs of an infant using a video system for the purpose of determining whether the infant suffers from or is at risk of suffering from a medical condition such as cerebral palsy.

The invention discloses a fixing device for constraining the body position of a cerebral palsy child. The fixing device comprises a fixed base, a cushion plate, a lower limb blocking cover, a lower limb air cushion, a connecting plate, a backup plate, a sliding groove, a first bolt, a spring, a push plate, a fixing plate, side plates, a head air cushion, a fixing sleeve, a second bolt, a universalball head and a supporting frame. According to the fixing device for constraining the body position of the cerebral palsy child, firstly, through soft contact four-limb constraint design, the four limbs of the cerebral palsy child can be effectively limited, soft contact can be further achieved, and the comfort of the four limbs of the child is improved,; secondly, through the cooperative effectof head adjusting and limiting structures, the head posture of the cerebral palsy child can be limited, then following feeding is convenient, and the clinical practicality is improved; in addition, asthe universal ball head mechanism is arranged in the fixing device, effective movement of the upper limbs of the child with high muscular tension can be achieved, finally convenience and high efficiency of nursing of the cerebral palsy child are greatly improved, the operating burden on nursing staff is also relieved, and the good application and popularization purpose is achieved.

The invention discloses a wearable gait detection and analysis system for a brain paralysis patient. The system comprises a pressure sensor for measuring pressure change values of foot soles during walking of a user, an inertia sensor for detecting movement trails of the foot soles and knees during walking of the user, a distance sensor for measuring the values of the distances between the foot soles and the ground during walking of the user, a processor for processing the pressure change values, the movement trails and the values of the distances to obtain gait data of the user, and a wireless communication module for sending the gait data to a server, analyzing and evaluating gaits of the user within a preset period by the server according to the gait data and sending the evaluation result to terminal equipment for display. The system is portable, wearable and convenient to use, the data can be monitored and acquired for a long time, information can be accurately and comprehensivelyacquired, and gait information of the user can be effectively acquired.

The present invention relates to dispersed solid medicine composition, named as Xingnaojing, for treating infantile externally caused fever heat, infantile viral encephalitis fever heat, infantile supurative tonsillitis, senile cerebral vascular dementia and cerebral apoplexy in recovering stage. The solid medicine composition consists of musk, borneol, volatile curcuma root oil, total curcuma root curcumin and total cape jasmine glycoside, and is prepared into dripping pill, suppository, capsule, tablet, granule or other forms. The preparation process has separate extraction of the active components curcumin and total cape jasmine glycoside, high shearing technology and sealed circular apparatus for well maintenance of active components and quantitative indexes for the control of active components so as to ensure the stable quality and curative effect of the product.

The invention relates to a cerebral apoplexy treating effervescence tablet and its preparation method, wherein the formula of the preparation comprises dried cerebral thrombus-treating concrete powder, cross bonding polyvinylpyrrolidone, mannitol, waterless lemon acid, sodium hydrogen carbonate, crystalline cellulose, miropowdered silica gel, magnesium stearate, talcum powder and Aspartame. The preparation employs a direct tabletting method, the bioavailability of the medicament can be improved, and the invention also has the advantages of convenient administration, reduced irritation to esophagus and gastrointestinal tract.

A Chinese medicine in the form of foot bath liquid for treating cerebroplegia and hydrocephalus is prepared from 13 Chinese-medicinal materials including gastrodia tuber, safflower, Chinese angelica root, chrysanthemum flower, etc through slicing, proportional mixing, decocting and filtering.

The invention discloses an alpha-mangostin derivative in preparation of an anti-cerebral palsy medicine and an anti-cerebral palsy medicine composition. The effective ingredient of the anti-cerebral palsy medicine composition is the alpha-mangostin derivative. By applying the alpha-mangostin derivative in the preparation of the anti-cerebral palsy medicine, the reduced learning and memory abilityof the brain caused by hypoxia ischemia and infection can be restored, the gait balance ability can be improved, and the damage of neuronal organelles can be relieved.

The invention provides a steroid compound, a preparation method thereof, a medicinal composition containing the compound and application of the compounds, which belong to the technical field of medicaments. The steroid compound is named as 14,16-dihydroxy-diosgenin (14,16-diosgenin), and the invention also provides the preparation method of the compound and application of the compound in preparing medicaments for preventing and / or treating hyperlipemia, adiposis and cerebral apoplexy. The steroid compound has the functions of lowering blood fat, reducing organism total fat, resisting acute cerebral ischemia and the like, and provides the probability of developing a novel medicament for treating the hyperlipemia, adjusting body fat of adiposis patients and resisting the cerebral apoplexy.

The invention provides a traditional Chinese medicine composition, which consists of raw materials in the following weight portion: hirudo, gadfly, eupolyphaga, angelica, radix paeoniae rubra, ginseng, radix astragali, peach kernel, oyster, semen vaccariae, radix curcumae, rhizoma corydalis, radix bistortae, amomum fruit, and angelica dahurica. The invention also provides a traditional Chinese medicine preparation containing the composition and a method for preparing the same. The traditional Chinese medicine composition and the traditional Chinese medicine preparation are mainly used for treating cerebral apoplexy, cerebral infarction or cerebral tumor which is distinguished to belong to Qi-deficiency and blood stasis syndrome by the traditional Chinese medical science.