135results about How to "Improve water solubility" patented technology

The disclosed preparation method for chitose/chitosan oligosaccharide with low molecular weight as 0.18-15mega and well water-solubility comprises: preparing water-soluble chitosan by acetylization; degrading the product with non-specific hydrolase while controlling the enzyme dosage and reaction time; adjusting the degraded product pH value to 8-9 with KOH or NaOH solution; depositing with ethanol, cleaning, and vacuum drying the final product with free amidogen that can promote wound healing, restrains tumor cell growth and improves human immunity. Compared with prior art, this invention is convenient to control for wide application.

The invention discloses a bacteriostatic hydrocolloid dressing and a preparation method thereof. The dressing comprises a polyurethane film, a hydrophilic colloid layer and a peeling layer which are adhered in turn. The preparation method comprises the following steps of: mixing a medical grade rubber substrate, gelatin, mineral oil, an antioxidant, sodium carboxymethyl cellulose, calcium alginate, a tackifier, O-carboxymethyl chitosan and dried nano-silver powder uniformly to obtain a blend; uniformly coating the obtained blend on the polyurethane film to form the hydrophilic colloid layer; covering the peeling layer on the hydrophilic colloid layer; and stamping to obtain the bacteriostatic hydrocolloid dressing. The bacteriostatic hydrocolloid dressing of the invention has high bacteriostasis, and simultaneously has the characteristics of high capacity of absorbing transudate, waterproofness, air permeability, firm adhesion, high compliance, capability of meeting diversified requirements on complicated wound, and simple and easily-implemented preparation method.

The present invention is process of preparing water soluble epoxy resin curing agent. The preparation process includes the following steps: 1. ring-opening reaction of polyethylene glycol and bisphenol A type epoxy resin under the action of catalyst to produce modified epoxy resin with epoxy groups in two ends; 2. dropping the modified epoxy resin into polyethylene polyamine to produce end amino-epoxy addition compound; 3. dropping compound 501 into the addition compound to produce end capping product; and 4. dropping organic acid into the end capping product to form salt and adding certain amount of water to produce the water soluble epoxy resin curing agent. The synthesized curing agent has high water solubility, capacity of well controlling reaction with polybasic amine and high flexibility.

An ethoxylate ester quaternary ammonium salt has chemical structural formula as follows, wherein R is C6-C22 saturated or unsaturated straight-chain or branched-chain alkyl; X represents an alkylated anion; n is the number of hydroxyethyl in the ester quaternary ammonium salt, and is 0, 2 or 3; n+b=3; b is 1, 2 or 3; and m is the number of ethoxyl, and is 1-30. The method has advantages of high conversion rate and good selectivity. The product has high content of active matters.

The invention discloses a glucose-containing platinum complex for treating tumors and a preparation method thereof. The compound is represented by a formula (I). Tests prove that the complex disclosed by the invention and a medicine prepared from the complex have high water solubility and tumor target effect and can be used conveniently in clinic.

The invention discloses a method for preparing wrapped nanometer zero-valent iron with modified graphene oxide as a carrier. The method comprises the following steps that firstly, wrapped nanometer zero-valent iron is prepared; secondly, graphene oxide is modified; thirdly, the obtained modified graphene oxide is added to water, graphene oxide suspension liquid is obtained after ultrasonic dispersion is conducted for one to three hours, then the obtained wrapped nanometer zero-valent iron is added to the graphene oxide suspension liquid, filtering, washing and drying are conducted after stirring is conducted sufficiently, and then the wrapped nanometer zero-valent iron adsorbent with the modified graphene oxide as the carrier is obtained. According to the method, cheap and harmless tea polyphenol, agar and water soluble starch are taken as the surface modifier to prepare the wrapped nanometer zero-valent iron, and the target pollutant removal rate is increased; the surface of the graphene oxide is modified by means of covalent bonds, the maximum Cr6+ absorption capacity of the modified graphene oxide is 390 mg/g, and the absorption capacity is greatly improved by one to two times.

The invention relates to celastrol, a celastrol derivative, a method for preparing the celastrol derivative, biogenetic salt prepared from the celastrol derivative serving as a raw material, and application of the celastrol derivative to the preparation of an antitumor medicine. The celastrol derivative has a structure shown as a formula I, wherein R1 is H, C1-C6 straight-chain or branched-chain alkyl, benzyl and benzyl with a substituent group on a benzene ring; and R2 or R3 are independent C5-C6 cyclic hydroxyl, C1-C6 chain alkyl, phenyl and substituted phenyl respectively, or R2 and R3 are cyclized with N, and the cycle is hexahydric cyclic heterocycle containing N or O. The celastrol derivative has high antitumor activity, stability and water solubility. The celastrol derivative can be salified with one of medically acceptable inorganic acids (such as hydrochloric acid, sulfuric acid and phosphoric acid) or organic acids (citric acid, cinnamic acid, succinic acid and the like); and the salt has high water solubility.

An inclusion compound of cefuroxime axetil with high solubility, stability and activity contains cefuroxime axetil and the pharmacologically acceptable cyclodextrin chosen from alpha-cyclodextrin, beta-cyclodextrin, gamma-cyclodextrin and their derivatives. Its preparing process is also disclosed.

The invention discloses antibacterial nanofibers or master batches and a preparation method thereof, including components of an antibacterial polymer resin solution and the preparation method of the antibacterial nanofibers or master batches. The antibacterial nanofibers or master batches are characterized by being formed through electrostatic spinning, melt-blowing, fibrillation and two-component compound methods on antibacterial polymer resin solution. Photosensitive molecules in the antibacterial nanofibers or the antibacterial master batches are antibacterial, do not generate a dissolution phenomenon, and are high in efficiency, wide in spectrum and antibacterial; the high temperature resistance of an organic antibacterial agent material is effectively provided; and the application range of an antibacterial agent is further expanded.

The invention discloses a PEGylated scutellarin compound and a preparation method thereof. The PEGylated scutellarin compound is as the shown formula (IV) and the PEGylated scutellarin compound can be applied to preparing medicaments applied to treating cerebral thrombosis, cerebral infarction, cerebral apoplexy, sequelaes caused by cerebral apoplexy, coronary heart disease or angina. Compared with the original scutellarin compound, the water solubility of the scutellarin compound is increased obviously; simultaneously, pharmacodynamics experiment on the mice model of cerebral ischemia-reperfusion shows that: compared with the original medicament, the biological activity of the scutellarin promedicament is strengthened obviously.

The invention discloses a production process of extraction soybean peptide and isoflavone from bean sprout, comprising refining, filtering, acid precipitation, centrifugal separation for protein solution, purified water call back, decolor, desalination, call back, enzymatic hydrolysis, ion exchange, drying concentration to get soybean peptide; desalination, resin adsorption, alcohol washing, dealcoholization, drying concentration to centrifugal separated whey solution to get soybean isoflavone. The invention adopts bean sprout as raw material and percolation technique by ultrafiltration membrane, which can not only save energy and recycle waste water, but also can realize cleaner production with discharge of waste water reduced.

The invention discloses a preparation method of a colloidal solution of nano-ZnO. The method comprises the following steps: mixing an aqueous modified cellulose solution having a concentration of 0.001-100g/L with a zinc salt solution having a concentration of 0.01-100g/L according to a volume ration of 1:10-100:1, wherein the modified cellulose is dialdehyde hydehydroxypropyl methyl cellulose obtained through the selective oxidation of the secondary hydroxyl groups in the C2 and C3 positions of hydroxypropyl methyl cellulose; and slowly adding an alkaline solution for adjusting the pH value to 8.5-11.5, and stirring at 20-90DEG C for 1-600min until reaction completion in order to obtain the colloidal solution of nano-ZnO having an average particle size of 1-100nm. The prepared nano-ZnO has the advantages of ultrahigh stability, antibiosis and ultraviolet resistance, good biocompatibility and good biodegradability, and can be applied to the coat field, the textile field, the medical health field and the like.

A composite medicine with high solubility, stability and activity and low hemolytic irritation contains cefteram ester and the pharmacologically acceptable dextrin chosen from beta-cyclodextrin and its derivatives. Its preparing process is also disclosed.

The invention discloses a cationic styrene acrylate emulsion as well as a preparation method and application thereof. The preparation method comprises the following steps: (a) mixing (methallyl) acrylate, (methallyl) styrene and (methallyl) acrylic acid to obtain a mixed monomer a; (b) mixing emulsifier, initiator and water to obtain an aqueous solution b; (c) mixing a cationic monomer and water to obtain an aqueous solution c; (d) adding the mixed monomer a into the emulsifier, the initiator and the water to mix to obtain a mixed monomer solution d; and (e) adding the mixed monomer a into the emulsifier, the initiator and the water to react, dropwise adding the solution d, the emulsifier, the aqueous solution b and the aqueous solution c to react, and neutralizing by using an alkaline solution to obtain a product; the cationic monomer is selected from p-vinyl-benzyl-trimethyl ammonium chloride or p-methyl-benzyl-trimethyl ammonium chloride. The adsorption and the retention of emulsion on the surface fiber of paper are improved, the surface strength of the paper is remarkably enhanced, and the Cobb value of an ash bottom whiteboard is remarkably reduced.

The invention belongs to the technical field of surfactants for fine chemistry and discloses a novel sugar-based surfactant, namely, alkoxyethyl-beta-D-xylopyranoside in order to solve the problem of limitation to application of traditional alkyl glycoside as the surfactant due to the fact water solubility of traditional alkyl glycoside is gradually reduced with increase of carbon chain length. Compared with traditional alkyl glycoside with the same carbon chain length, the surfactant has better water solubility and surface activity as well as selectable and controllable foaming capacity and emulsifying property. Besides, raw materials for synthesis comprisexylose obtained from waste crop leftovers and naturally-sourced fatty alcohol and have rich sources. The glycoside can be widely applied to application industries such as biochemical engineering, pharmacy, pesticides, food processing, cosmetics, scientific research and the like.

The invention discloses a liquidambaric acid or ursolic acid nano-granule, a preparation method and an application thereof. The liquidambaric acid or ursolic acid nano-granule is prepared by the following steps: taking the liquidambaric acid or ursolic acid as a core material, taking one or two mixtures of the gelatin, B-cyclodextrin, rubusoside, soluble starch, stevioside and thea saponin as a wall material, wherein the mass ratio of the core material to the wall material is 1:(5-100). The preparation method is an ultrasonic high-speed refiner method or a high energy ball milling method. By adopting the liquidambaric acid or ursolic acid nano-granule, the cell permeability can be improved and the growths of the human colon carcinoma cell HT-29, the human prostate cancer cell DU145 or the human breast cancer cell MDA-MB-231 can be inhibited.

The invention discloses a polyacrylonitrile modified starch nano-fiber and a preparation method thereof. The method comprises the following steps: preparing a starch grafted acrylonitrile polymer; dissolving the polymer into an organic solvent to prepare an electrostatic spinning liquid; and preparing the polyacrylonitrile modified starch nano-fiber by adopting an electrostatic spinning process, wherein (1) gelatinizing starch in an aqueous solution under N2 protection, and initiating the acrylonitrile to perform free radical polymerization with ceric ammonium nitrate under an acid condition to obtain a starch grafted acrylonitrile; (2) preparing electrostatic spinning liquid from the substance obtained in the step (1) for electrostatic spinning; and (3) preparing the polyacrylonitrile modified starch nano-fiber by adopting an electrostatic spinning process under a condition that the spinning environment temperature is 30-60 DEG C. The polyacrylonitrile modified starch nano-fiber preapred by adopting the method has a diameter of 80-600nm, and has relatively uniform diameter, does not have beading or fracturing; and the hydrophobic property, spinning property and film forming property of the material can be reinforced.

The invention discloses an astragaloside water-soluble derivative, namely astragaloside acid or medicinal salt, ester and amide of the astragaloside acid, with the structure shown in the formula 1. According to the defects that water solubility of astragaloside is poor, so that bioavailability of astragaloside is affected, and astragaloside cannot be developed into a single-component medicine, special alcoholic hydroxyl groups in astragaloside molecules are directionally oxidized into carboxyl groups ingeniously, and the astragaloside water-soluble derivative, namely astragaloside acid is prepared. A preparation method is simple in step, mild in reaction condition, small in side reaction, high in yield, easy to implement and suitable for large-scale production. The astragaloside water-soluble derivative, namely astragaloside acid or medicinal salt, ester and amide of the astragaloside acid, with the structure shown in the formula 1 has a protective function on hypoxia injuries of cardiac muscle cells cultured in vitro, and can be used for preventing and/or treating relevant cardiovascular diseases. The formula 1 is defined in the description.

The invention relates to a preparation method of a water-soluble natural bacteriostatic agent, and belongs to the application field of natural product active ingredients. Particularly, the invention relates to a preparation method of a water-soluble cyclodextrin using a derivative of hexahydro beta-acid of beta-acid in lupulus. According to the method, nine kinds of different cyclodextrin including hexahydro beta-acid, alpha-cyclodextrin, beta-cyclodextrin, gamma-cyclodextrin and derivatives thereof and the like are used for inclusion; the cyclodextrin inclusion compound capable of improving the water solubility of the hexahydro beta-acid is obtained; according to requirements, the compound can be used in food proportioning, beverage proportioning, cosmetics, washing and caring articles and feed products for improving the anti-corrosion performance and the health care effect of the products.

A method for reducing the transmittance of ultraviolet radiation through an intraocular lens to 10% or less at 370 nm by (a) polymerizing a mixture comprising: at least one first monomer and a second monomer comprising a trisaryl-1,3,5-triazine moiety, (b) forming an optic portion from the copolymer wherein the second monomer is present in about 0.10 to about 0.20 percent by weight of the overall polymer and wherein the optic portion of the intraocular lens displays essentially the same physical properties such as, for example, refractive index as the optic portion of the intraocular lens formed from the polymerized mixture of (a) without the second monomer, but otherwise identical conditions. Additionally, a method for preventing the transmittance of at least 90% of ultraviolet radiation at 370 nm through a foldable intraocular lens comprising: (a) incorporating a monomer comprising a 4-(4,6-diphenyl-1,3,5-triazin-2-yl)-3-hydroxyphenoxy moiety into at least one polymer and (b) forming the polymer into a material suitable for use as an intraocular lens, wherein the monomer comprising a 4-(4,6-diphenyl-1,3,5-triazin-2-yl)-3-hydroxyphenoxy moiety comprises 0.10 to 0.15 weight percent of the overall dry polymer.

The invention discloses a biodegradable redox sensitive polymer and a preparation method and application thereof. The biodegradable redox sensitive polymer adopts a core-shell structure, the hydrophilic end,namely an outer shell, is hyaluronic acid, and the hydrophobic end, namely an inner core, is vitamin E succinate. Thehyaluronic acid and the vitamin E succinate are connected by using a disulfide bond as a connecting bridge to prepare the polymer having a redox response property, and the polymer can form nanomicelles spontaneously in water through hydrophilic and hydrophobicacting forces and has the advantages of good biodegradability, small toxic and side effects, good responsiveness and the like; the polymer forms the nanomicelles in water through the hyaluronic acid and the natural vitamin E succinate existing in a human body, so that loading of a variety of medicines can be achieved; and the polymer has a good application prospect in the field of medicine science.

The invention belongs to the technical field of medicines and particularly relates to vortioxetine p-hydroxy benzoate comprising an anhydrous crystal form and a hydrate crystal form of vortioxetine p-hydroxy benzoate as well as a preparation method and application of vortioxetine p-hydroxy benzoate. The preparation method comprises the following steps of reacting vortioxetine and p-hydroxy benzoic acid in an organic solvent or a mixed solvent system of an organic solvent and water to produce salt, carrying out heat preservation or cooling and crystallizing to obtain vortioxetine p-hydroxy benzoate. The solubility, stability, flowability, compressibility and the like of prepared vortioxetine p-hydroxy benzoate are greatly improved compared with those of vortioxetine, which is conductive to preparing pharmaceutical preparations and improving the quality.

The invention provides a salicylic metal complex containing quaternary ammonium cation in a molecular structure, which aims at (1) improving water solubility of salicylic metal complex by virtue of water solubility and surface activity feature of quaternary ammonium salt, and facilitating blending and application of the salicylic metal complex as a bioactivity reagent; (2) by virtue of positive charge characteristics of quaternary ammonium salt, promoting the salicylic metal complex to contact bacteria, fungi or cells and effect quickly; (3) producing cooperative and efficient bioactivity and effects by virtue of bioactivities of quaternary ammonium salt and salicylic metal complex, such as double bactericidal activity, anti-microbial activity and bacteriostatic activity.

The invention discloses a refreshing mint tremella dairy drink. The refreshing mint tremella dairy drink is made from, by weight, 190-200 parts of tremella, 10-12 parts of dried skim milk, 12-13 parts of sweet tea, 7-10 parts of hawthorn, 6-9 parts of perilla leaves, 3-4 parts of mint, 0.4-0.5 part of stevioside, 4-6 parts of osmanthus fragrans, 13-15 parts of linden honey, 15-18 parts of gynostemma pentaphylla, 15-18 parts of soft sugar, 1-2 parts of gelatin and appropriate streptococcus thermophiles and lactobacillus bulgaricus. Tremella fluid undergoes etherification reaction with sodium citrate in the production process of the dairy drink, polysaccharide molecules of the tremella are subjected to hydroxylation modification, water solubility of the polysaccharide molecules can be improved, and antioxidant activity of the product is improved. The added perilla leaves, osmanthus fragrans and the like make the dairy drink have a unique taste and mellow fragrance; the added mint makes the dairy drink refreshing, the added herb ingredients such as the sweet tea and the hawthorn improve healthcare value of the dairy drink, and the dairy drink has efficacy of promoting urination for depressurization, improving digestion and the like.

The invention aims to provide a novel glucosyltransferase, which can be used for performing galactosylated modification on Macrolactins macrolide compounds. According to the glucosyltransferase, the water solubility of the macrolide compounds can be improved through glycosylation to the Macrolactins, further the bioavailability of the macrolide compounds can be improved, the pharmacological effect is enhanced, the toxic or side effect is reduced and a new strategy is provided for medicine research of the macrolide compounds.

The invention discloses antibacterial and injectable temperature-sensitive chitosan gel dressing and a preparation method thereof. The dressing has the antibacterial function and the temperature-sensitive performance, and it can be achieved that the dressing is instantly congealed while sprayed. The preparation method of the antibacterial and injectable temperature-sensitive chitosan gel dressingcomprises the following steps that quaternized chitosan is prepared, the main chain of the chitosan is grafted with poly(N-isopropyl acrylamide)(PNIPAM) through an emulsion polymerization reaction, and accordingly, the antibacterial and injectable temperature-sensitive chitosan gel dressing is prepared. The dressing is high in water solubility at the room temperature, and the antibacterial temperature-sensitive chitosan gel dressing can be used after spray coating.

The invention discloses a multifunctional high-polymer prodrug nano-scale drug delivery system as well as a preparation method and use thereof. A multifunctional high-polymer is characterized in that polyglutamy sodium glutamate is bonded with an anti-cancer drug, namely paclitaxel, so as to form a high-polymer prodrug PGG-PTX, and then the high-polymer prodrug PGG-PTX is linked with a T1 contrast agent Gd-DTPA through a peptide bond to form PGG-PTX-DTPA-Gd; and the multifunctional high-polymer has a structure represented by the following formula (shown in the description) and is clinically applied to the non-invasive diagnosis of neuclear magnetic resonance imaging on solid tumors. The nano-scale drug delivery system is characterized in that the system is of a sphere with a particle size of 30nm-40nm; free Gd-DTPA and PGG-PTX are linked together through the peptide bond, so that the relaxation rate of free Gd-DTPA is increased from 3.87nM<1>S<1> to 18.98nM<1>S<1> and is increased by 4.9 times; a high-polymer prodrug can form nano-particles in water through self-assembling, so that the water solubility and biocompatibility of the drug are improved, and the treatment effect and bioavailability of the drug are increased; the system can be applied to intravenous injection and can be passively targeted to tumors by virtue of a tumor EPR effect and has an obvious inhibition effect to the growth of lung cancer tumors; and the system can be applied to the integrated diagnosis and treatment of tumors.

The invention discloses an erdosteine compound for treating respiratory tract inflammation and a preparation method of the erdosteine compound, belonging to the technical field of medicines. The X-ray powder diffraction patterns of the erdosteine compound measured by using Cu-K alpha rays are shown as the Figure 1. The erdosteine crystal provided by the invention is stable in chemical properties and high in water solubility, has high stability, brings convenience to various preparations and is very suitable for clinical application.

The invention discloses a difunctional-group-modified chitosan derivative and a preparation method thereof. The chitosan derivative has a molecular structural formula (I) shown as in the description. According to the preparation method, chitosan is reacted with thiourea trioxide and arginine, respectively, under a certain condition to obtain the difunctional-group-modified chitosan derivative. The difunctional-group-modified chitosan derivative is treated through a deionized water dialytic method to remove micromolecular by-products or impurities for sample purification. The dialyzed aqueous solution is dried through freeze drying to obtain the final product. Chitosan is subjected to difunctional modification, and guanidine radicals and arginine modify the molecular chain of chitosan at the same time, so that chitosan is endowed with excellent antibacterial property and better biological safety. The preparation method is mild in reaction condition and suitable for industrial production. The modified derivative is good in water solubility and greatly improved in antibacterial effect, is excellent in biological safety, is a high-quality natural polysaccharide-modified green antibacterial material, and has great development prospects in the market.

The invention discloses an acid-sensitive polymer carrier for delivering antitumor drugs, and a preparation method and a drug carrying application thereof. The polymer carrier is prepared through connecting sodium polyglutamate with carboxymethylcysteine through a peptide bond. The polymer carrier is used for delivering paclitaxel, doxorubicin, camptothecin and other antitumor drugs, polymer prodrugs formed through bonding the carrier with the drugs can self-assemble in water to form nanoparticles, so the water solubility and the biocompatibility of the drugs are improved, drug release is accelerated in tumor acidic environment, and the curative effects and the bioavailability of the drugs are improved.