275 results about "Alpha-Cyclodextrin" patented technology

Oral rinse and dentifrice compositions, comprising a phenolic selected from the group consisting of menthol, eucalyptol, methyl salicylate, thymol, triclosan, and mixtures thereof; and a cyclodextrin selected from the group consisting of hydroxypropyl β-cyclodextrin, hydroxyethyl β-cyclodextrin, hydroxypropyl γ-cyclodextrin, hydroxyethyl γ-cyclodextrin, α-cyclodextrin, methyl β-cyclodextrin, and mixtures thereof. These compositions are useful in retarding the development of plaque, treating gingivitis, and in treating the presence of micro-organisms in the oral cavity.

The present invention provides a gasified food product comprising a solid-gas clathrate and methods for making the same. The solid-gas clathrates used in the present invention are selected from the group consisting of an α-cyclodextrin-gas clathrate and a derivative thereof. Furthermore, the present invention provides food products such as a powdered coffee mix, dough, sauce, soup, hot cereal and the like comprising the solid-gas clathrate.

The invention discloses a method for in-situ preparing antibacterial supermolecule aquogel. The method comprises the following operation steps: silver nitrate crystal and polyethyleneglycol-polypropylene glycol-polyethyleneglycol triblock copolymer solution are mixed and stirred to obtain mixed solution; the steps of stirring the mixed solution for 15 minutes and ultrasonically dispersing the mixed solution for 5 minutes are alternatively carried out for 2-4 hours to obtain nano silver sol; and the nano silver sol and Alpha-cyclodextrin solution are mixed, stirred and stands at the room temperature to obtain hydrogel. The hydrogel can be used for preparing injectable drug carriers. The invention has the advantages of simple operation, adjustable gel strength and the gelation time, room temperature forming, no involvement of chemical cross linking reaction and the usage of organic solvent, favorable biocompatibility and antibacterial property of obtained gel, and the like and is prospective to be widely applied in the field of biomedical engineering materials.

The invention aims to provide an active oxygen free radical sensitive cyclodextrin material as a drug delivery carrier. The chemical structure of the cyclodextrin material is disclosed in the specification, wherein n is equal to 6, 7 or 8 which are respectively corresponding to active oxygen free radical sensitive alpha-cyclodextrin, beta-cyclodextrin or gamma-cyclodextrin material; R is -H or disclosed in the specification; and the glucose unit of each cyclodextrin molecule at least has one R group disclosed in the specification. The invention also provides a preparation method of the cyclodextrin material.

The present invention is based on the unexpected discovery that CoQ-10 can be made commercially in a highly bioavailable form suitable for topical, sublingual formulations, or for oral ingestion. One such bioavailable form is a water dispersible freeze-dried CoQ-10/γ-cyclodextrin complex. Complexation in general with γ- or α-cyclodextrin improved the cellular uptake of CoQ-10 as compared to water dispersible liposomal or micellar forms of CoQ-10. Thus, the present invention includes a highly bioavailable CoQ-10/cyclodextrin complex for use in the nutritional supplement, oral care, and pharmaceutical industry.

The invention provides a remediation agent and application for combined contaminated soil. The remediation agent is composed of, by weight, 30%-50% of biomass charcoal, 10%-20% of hydroxy calcium phosphate, 10%-20% of potassium humate, 10%-20% of alpha-cyclodextrin, 5%-10% of kieselguhr and 5%-10% of plant ash. The components give full play to the synergistic effect, through the effects of chelating, depositing, adsorbing, improving, PH value adjusting and the like, the content of available heavy metal in the soil is made to be decreased greatly, and the prepared soil remediation agent has a good effect during cadmium-lead-arsenic combined contaminated soil remedying. The remediation agent for the combined contaminated soil has the advantages that the preparation method is simple and practicable, and the remediation effect is good.

The present invention provides a method of treating a subject suffering from wet acute macular degeneration which comprises administering to the subject an amount of a modified alpha cyclodextrin effective to treat the subject, wherein the modified alpha cyclodextrin binds to bioactive lipids which accumulate in the subject's eye and are characterized by the presence of a single chain of fatty acids.

The invention discloses technology for producing alpha-cyclodextrins (alpha-CGT) by a biological method, belonging to the technical field of cyclodextrins production. The alpha-CGT is produced by adopting alpha-cyclodextrins glycosyltransferase (alpha-CGTase) derived from paenibacillus macerans (China Center for Type Culture Collection of Microbe, CCTCCM 208063). By applying the technology to produce alpha-CGT, the total conversion of starch is as high as 71%, and in the product, alpha-CGT accounts for 80% and beta-CGT accounts for 20%. The technology has the advantages of simple flow, short production cycle, high conversion and high purity of the obtained alpha-CGT, etc.

The invention discloses a functionalized Fe3O4 nano-particle and a preparation method and application of the functionalized Fe3O4 nano-particle. The preparation method comprises the following steps of: (1) under inert atmosphere, adding FeCl2 and FeCl3 into the mixed solution of sodium hydroxide aqueous solution and hydrochloric acid solution for reaction to obtain Fe3O4 nano-particles; and (2) reacting carboxymethyl-alpha-cyclodextrin with Fe3O4 nano-particles in PBS (Phosphate Buffer Solution), thereby obtaining the functionalized Fe3O4 nano-particles. The Fe3O4 nano-particle modified by alpha-cyclodextrin provided by the invention can simultaneously have good enrichment and purification abilities to trace phenylarsonic acid in complex samples; and meanwhile, the Fe3O4 nano-particle is superparamagnetic, so that centrifugation is not needed in sample processing, the pretreatment procedures of the sample are greatly simplified, the pretreatment time is shortened, and the pretreatment efficiency of the sample is improved.

The present invention relates to a novel treatment composition for use in treating food products and food intermediates. The treatment composition may be used in single, home use settings as well as commercial applications for larger scale treatment of food products in the course of manufacture. The treatment composition of the present invention uses at least one of alpha-cyclodextrin, beta-cyclodextrin, gamma-cyclodextrin or combinations and modified derivatives thereof along with a suitable carrier such as in an aerosol, liquefied mister and the like.

The invention belongs to the technical field of medicines, and in particular relates to a curcumin and mixed-cyclodextrin inclusion compound and a preparation method thereof. The technical scheme provided by the invention is as follows: an alpha-cyclodextrin, beta-cyclodextrin and gamma-cyclodextrin mixture and curcumin are adducted in a low-concentration ethanol-water solution, the inclusion rate is improved, and the dissolvability and the stability are enhanced.

The invention discloses a process for producing recombinant alpha-cyclodextrin glucosyltransferase in a fermenting way by culturing escherichia coli in high density through a temperature two-stage control strategy and a constant oxygen-dissolved and feed-supplemented batch technology, belonging to the technical field of fermentation engineering. The method comprises the following steps of: inoculating recombinant escherichia coli BL21(DE3) as a production strain at the inoculation quantity of 5-10 percent and fermenting in batch; starting adding a supplementing liquid in a flowing mode when dissolved oxygen rises to about 80-100 percent, ensuring that a strain body exponentially grows, controlling the temperature of the growth phrase of the strain body to be 33-37DEG C and maintaining the dissolved oxygen to 20-30 percent; adding 0.75-1.5 percent (mass volume percent) of glycine when the strain body OD600 reaches about 15-30; reducing the temperature to be 23-27DEG C and continuously supplementing 0.2-0.4g.l<-1>.h<-1> when the strain body OD600 reaches 45-60 and supplementing the supplementing liquid by adopting a gradient diminishing mode at the same time; and enabling the enzymeactivity of the extracellular alpha-cyclodextrin glucosyltransferase to reach 200-280U/ml by fermenting culture for 30-35 hours. By adopting the strategy to ferment, the invention realizes the high-efficiency extracellular expression of the alpha-cyclodextrin glucosyltransferase and greatly improves the production intensity. The invention has the advantages of wide source of raw materials, simple and feasible process and suitability for large-scale production; with effective extracellular expression, the pollution on host bacteria hybrid proteins can be greatly reduced and the purification efficiency of the protein can be improved. The invention lays a foundation for large-scale production of the alpha-cyclodextrin glucosyltransferase.

The invention relates to an addition agent for lowering the content of N-nitroso compound in cigarette and the cigarette production process, wherein the addition agent is a plant polyphenol microcapsule with plant polyphenol as the core, and alpha-cyclodextrin or beta-cyclodextrin or hydroxypropyl beta-cyclodextrin is used as molecular embedding agent for charging plant polyphenol microcapsule into the molecular embedding agent, forming stabilized colloid, by dissolving the colloidal solution and adding into the shredded tobacco, the content of N-nitroso compound in cigarette can be substantially reduced.

The invention relates to a ginkgolide B nanoliposomes drug and a method for preparing the same. The invention provides the ginkgolide B nanoliposomes drug including the following materials and the following radios: 8-12 mol compositions of cephalin and distearoyl choline with mole ratio of 1:3-6; 6-8 mol compositions of sojasterol and cholesterin with mole ratio of 1:2-4; 4-6 mol compositions of gamma-cyclodextrin/2-hychoxypropyl-beta-cyclodextrin and alpha-cyclodextrin with mole ratio of 3:1; 0.2-0.4 mol methoxy polyethylene glycol 2000-hydrogenated soybean phosphatidylethanolamine; 2 mol ginkgolide B; and 0.1-0.5 mol vitamine E. A method for preparing the ginkgolide B nanoliposomes drug is also provided in the invention to produce the ginkgolide B nanoliposomes for target treating blocking of vessel or endothelial cell thereof, with a better healing effect than ordinary preparations of ginkgolide B.

The invention discloses a super-molecular hydrogel double-medicament carrier for simultaneously loading hydrophilic and hydrophobic medicaments and a preparation method as well as application thereof. The method comprises the following operating steps of: performing chemical modification on the hydrophobic medicament by using methoxypolyethylene glycol to synthesize a water-soluble macromolecularprodrug; physically mixing prodrug molecules with the hydrophilic medicament; further mixing the mixed solution with an alpha-cyclodextrin solution and stirring; and standing at room temperature to obtain the super-molecular hydrogel double-medicament carrier for simultaneously loading the hydrophilic and the hydrophobic medicaments. The carrier has the advantages of easiness in operation, adjustable gel strength and gelation time, forming at room temperature, no chemical crosslinking reaction or organic solvent, high bioavailability, sustainable and controllable release of the medicament andthe like, and is expected to be widely applied to the field of biomedical engineering materials.

The invention discloses supermolecular hydrogel and preparation method and application thereof. The preparation method of the supermolecular hydrogel comprises the following steps of: synthesizing a polyethylene glycol modified cation copolymer; mixing with a nucleic acid solution and standing to obtain a copolymer/nucleic acid composite solution; and finally, mixing with alpha-cyclodextrin solution, and standing to obtain the supermolecular hydrogel capable of acting on a gene vector material. In the forming process of the hydrogel disclosed by the invention, a chemical crosslinking reactiondoes not happen, and thus the influence of a byproduct of the chemical crosslinking reaction on the activity of nucleic acid is effectively avoided, an efficient gene transfer effect is realized, andthe transfection efficiency is obviously improved over the conventional gel material; and moreover, the preparation method is convenient and quick, realizes formation at room temperature, imposes relatively low requirements on concentration and temperature, and is favorable for maintaining the biological activity of embedded gene and the biocompatibility of the material.

The invention relates to a preparation method of a sulfur mesoporous silica composite material for nano-valve packaging. The method is as below: 1, preparing a mesoporous silica carrier by using a ''template method''; 2, carrying out surface modification on mesoporous silica by using an organic silane chain molecule; 3, injecting elemental sulfur into the pore tunnel or cavity of the mesoporous silica by a vacuum heat treatment method; and 4, then sealing pores of mesoporous silica by using alpha-cyclodextrin as a nano-valve. The invention applies the composite material to lithium-sulfur battery, uses the high specific surface area of mesoporous silica to solve the problem of lower sulfur content in lithium-sulfur battery cathode material of the prior art, and inhibits volume expansion of sulfur in the process of charging and discharging; and meanwhile the introduced nano-valve can inhibit the dissolution of polysulfide and improve the cycle stability of lithium-sulfur battery.

The invention relates to a modification method for improving the salt tolerance of a crylic acid macromolecule absorbent resin. The modification method which utilizes Alpha-cyclodextrin to improve the salt tolerance of the crylic acid macromolecule absorbent resin is characterized by comprising the following steps: 1) according to the parts of all component raw materials by weight as follows: 15 portions to 40 portions of crylic acid, 5 portions to 18 portions of sodium hydroxide, 0.02 portion to 1 portion of N, N'- methylene bisacrylamide, 0.05 portion to 2 portions of Alpha-cyclodextrin, 0.04 portion to 2 portions of ammonium peroxydisulfate and 15 portions to 54 portions of water, the raw materials are selected; 2) all raw materials are added into a reaction kettle with a water bath, the temperature is risen to 65 DEG C to 80 DEG C and the reaction lasts for 1 hour to 3 hours; 3) stirring in the reaction kettle is stopped and the kettle is allowed to stand for 0.5 hour to 2 hours and reaction mass in the reaction kettle is discharged; and 4) after being dried, the reaction mass is crushed, thus obtaining the modified crylic acid macromolecule absorbent resin. The method can evidently improve the salt tolerance of the crylic acid macromolecule absorbent resin prepared by the method can be evidently improved.

The invention discloses a stainless steel oxidizing layer cleaning agent and a preparation method and application thereof. The stainless steel oxidizing layer cleaning agent comprises the following raw materials: 30% to 50% of cyclodextrin, 10% to 20% of organic acid, 10% to 20% of a composite surface active agent, and the balance of water, wherein the cyclodextrin is a mixture of one or more than two of alpha-cyclodextrin, beta-cyclodextrin, gamma-cyclodextrin, hydroxypropyl beta-cyclodextrin and methylase beta-cyclodextrin; the organic acid is a mixture of one or more than two of methane acid, ethane acid, propionic acid, lemon acid, oxalic acid, maleic acid and lauric acid; the composite surface active agent is a mixture of one or more than two of sodium oleate, alkyl glycoside, lauryl sodium sulfate, coconut fatty acid diethanol amide, fatty alcohol-polyoxyethylene ether and polyethylene glycol. The stainless steel oxidizing layer cleaning agent has the advantages that the preparation method is simple, the use and operation are convenient, the service life is long, the generation amount of wastewater is small, the components can be easily and biologically degraded, the green and environment-friendly effects are realized, and the cost is low. The stainless steel oxidizing layer cleaning agent has the potentiality of replacing the existing stainless steel oxidizing layer cleaning agent using inorganic acid as the main component.

The invention relates to a reduced glutathione percutaneous absorption preparation and a preparation method thereof, and belongs to the field of medicinal preparations. In the technical problem, the invention provides a reduced glutathione percutaneous absorption preparation which has the sustained-release effect. The reduced glutathione percutaneous absorption preparation is prepared from an auxiliary material bag and reduced glutathione, wherein an auxiliary material is at least one of gamma-cyclodextrin, a derivative of the gamma-cyclodextrin, alpha-cyclodextrin and a derivative of the alpha-cyclodextrin. The reduced glutathione percutaneous absorption preparation has the advantages of quick response, long half-life period and high bioavailability, is convenient to use and does not have pain. The reduced glutathione provides a new preparation, and has a wide application prospect.