Curcumin and mixed-cyclodextrin inclusion compound and preparation method thereof

A technology of mixing cyclodextrin and inclusion compound, which is applied in the field of medicine, can solve the problems of low solubility and low inclusion rate, and achieve the effect of high inclusion rate, simple operation and improved inclusion rate

Inactive Publication Date: 2013-09-04
江苏丰园生物技术有限公司
View PDF3 Cites 17 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] The technical problem to be solved in the present invention is: to overcome the shortcomi...

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Curcumin and mixed-cyclodextrin inclusion compound and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] Embodiment 1: Research on inclusion process of curcumin and mixed cyclodextrin

[0018] (1) Determination of the optimal ratio of α-cyclodextrin, β-cyclodextrin and γ-cyclodextrin

[0019] Three different ratios of α-cyclodextrin, β-cyclodextrin and γ-cyclodextrin were selected. After many experiments, the mixed cyclodextrins containing different proportions were packaged at the same temperature and inclusion time. According to the level of inclusion rate, select the best ratio of α-cyclodextrin, β-cyclodextrin and γ-cyclodextrin. The data in Table 1 are obtained through experiments:

[0020] Table 1 Determination table of optimal ratio of α-cyclodextrin, β-cyclodextrin and γ-cyclodextrin

[0021]

[0022] Cyclodextrin cyclodextrin CD for short.

[0023] It can be seen from the experimental results that when the ratio of α-cyclodextrin, β-cyclodextrin and γ-cyclodextrin is 6:4:1 by weight, the inclusion rate of curcumin is the highest.

Embodiment 2

[0025] Mix 12 parts of cyclodextrin (the ratio of α-cyclodextrin, β-cyclodextrin and γ-cyclodextrin is 6:4:1), with 75 parts of water and 2 parts of 95% ethanol solution Mix, heat to 70°C to dissolve, cool to 55°C, add 2 parts of curcumin dropwise, and use a shearing machine to stir at 5000r / min for inclusion, keep the system temperature between 50-55°C, and cut for 50 minutes After passing the microscopic examination of the clathrate, the temperature was naturally lowered to room temperature, and the curcumin clathrate solution was spray-dried to obtain the product. The curcumin clathrate rate was 80.1%.

Embodiment 3

[0027] Mix 10 parts of cyclodextrin (the ratio of α-cyclodextrin, β-cyclodextrin and γ-cyclodextrin is 6:4:1), with 70-80 parts of water, 2 parts of 95% Mix the ethanol solution, heat to 70°C to dissolve, cool to 55°C, add 1 part of curcumin dropwise, and use a shearing machine to stir at 5000r / min for clathrate, keep the system temperature between 50-55°C, and cut 50 Minutes later, after passing the microscopic examination of the clathrate, the temperature was naturally lowered to room temperature, and the curcumin clathrate solution was spray-dried to obtain the product. The clathrate rate of curcumin was 90.1%.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

No PUM Login to view more

Abstract

The invention belongs to the technical field of medicines, and in particular relates to a curcumin and mixed-cyclodextrin inclusion compound and a preparation method thereof. The technical scheme provided by the invention is as follows: an alpha-cyclodextrin, beta-cyclodextrin and gamma-cyclodextrin mixture and curcumin are adducted in a low-concentration ethanol-water solution, the inclusion rate is improved, and the dissolvability and the stability are enhanced.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to an inclusion compound of curcumin and mixed cyclodextrin and a preparation method thereof. Background technique [0002] Turmeric has been widely used as food since ancient times. With the advancement of science and technology, people's understanding of turmeric and its main component curcumin has gradually deepened, and it has been found that curcumin has a wide range of medicinal effects. [0003] Curcumin not only has the effects of anti-human immunodeficiency virus (HIV), anti-cell aberration, and inhibition of platelet coagulation nuclei thrombosis, but also can scavenge oxygen free radicals, reduce lipid peroxide in blood and liver, and present a good hepatoprotective effect , can significantly reduce the total liposterol content, increase serum high-density lipoprotein content, reduce serum low-density lipoprotein content, and has a significant effect of lowering blood li...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
IPC IPC(8): A61K47/48A61K31/12A61P31/18A61P7/02A61P1/16A61P3/06
Inventor 徐文峰
Owner 江苏丰园生物技术有限公司
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap