162 results about "Lipid peroxide" patented technology

The present invention relates to the isolation and use of an allene oxide synthase enzyme as an antioxidant of lipid peroxides in biological systems. It is based, at least in part, on the discovery that antioxidation is accomplished enzymatically by RPP, a species of allene oxide synthase, in guayule, and on the discovery that the allene oxide synthase RPP disrupts the chain reaction and propagation steps of lipid peroxidation. The present further invention relates to the use of an allene oxide synthase to result in a time-dependent disappearance of conjugated dienes (i.e. lipid hydroperoxides). The allene oxide synthase rapidly converts free or esterified fatty acid peroxides or hydroperoxides into their corresponding epoxides, which, in turn are converted to ketols. The lipid peroxide and hydroperoxide substrates for this enzyme are known to be toxic to biological organisms and can generate additional peroxides by chain propagation reactions. In the presence of an allene oxide synthase these compounds are rapidly and effectively converted to allene oxides (the epoxide), thus breaking the chain reaction.

A process for obtaining the apolar extract comprises: (a) extracting the rhizomes with an organic solvent; (b) filtration and evaporation to dryness of the extract; (c) dissolution of the oleoresin obtained in hot conditions, precipitation while allowing to cool down and filtration of the solid; (d) drying and recrystallizing the solid in order to obtain a product having a purity in curcuminoids higher than 90%. Obtaining the polar extract comprises: (a') extraction of the rhizomes with water at 50-70° C. and (b') filtration and evaporation of the water. Application of the compositions and preparations as catchers of free radicals and antiageing agents, as well as reducing agents to reduce the plasma levels of lipid peroxides in human beings are disclosed.

The invention relates to Isopentenyl-oxyl substituted dehydrogenized silybin ether and the preparation method and the application thereof. The compound has the activity of eliminating extracorporeal extracorporeal 1-diphenyl-2-picrylhydrazyl radical, the activity of obviously inhibiting the generation of lipid peroxide induced by radical and the function of powerfully preventing the damage of therat adrenal pheochromocytoma PC12 cells due to the hydrogen peroxide, i.e. the function of preventing the oxidative damage of the PC12 cells simulating the brain nerve cells, thereby playing a positive role in preventing the brain cell tissue oxidation and brain never oxidation and preventing and treating the senile dementia and other neurodegenerative diseases. The pharmacodynamic result shows that 7-site substituted dehydrogenized silybin ether can be expectantly used for preparing the medicament for preventing and treating the neurodegenerative diseases.

The invention relates to a curcumin or curcumin-ramification-containing composite feed additive and a use thereof. The use of the additive can promote the growth of the animals, and/or protect the livers of the animals, and/or improve the oxidation resistance of the animals, reduce the generation of lipid peroxide, and improve the immunity and the disease resistance, and/or improve the stress resistance of the fish, avoid the problem of 'irritable haemorrhage', promote the secretion of fish mucus, and solve the problems that the cultivated fish is easy to loosen squama, easy to fall off, and lack of fish mucus. The invention further relates to a method for cultivating the animals and an animal feed which contains the composite feed additive having the curcumin or curcumin ramification.

The invention relates to a health product, in particular to a soft capsule and a method for producing the same. The soft capsule is characterized in that: the soft capsule contains water soluble pearl powder, selenium-enriched yeast, natural vitamin E, beeswax, glycerol monostearate, span-80 and corn oil. The soft capsule is a powerful antioxidant which can effectively improve the rancidity of fatty acid in food and the alimentary tract, and protect cells from being damaged by harmful matters generated by oxidation of unsaturated fatty acid; the soft capsule is an extremely good free radical scavenger which can protect biological membranes from being attacked by free radicals, effectively resist ageing nutrients, improve immunity of a human body, keep the integrity of red blood cells and promote the biological synthesis of the red blood cells; the soft capsule is an indispensible promoting factor for cellular respiration, which can protect the lung tissue from air pollution; moreover, the soft capsule also can prevent the over-aggregation of blood platelets, avoid the increase of lipid peroxidation in the blood, prevent cardiovascular diseases and supplementing calcium element in the human body.

The orally taken antioxidant and antilipemic medicines include solid orally taken preparation prepared with forsythin and solid excipient in the weight ratio of 0.01-4 through mixing and conventionaltechnological process, and liquid orally taken preparation prepared with forsythin and liquid excipient in the weight ratio of 0.003-0.01 through mixing and conventional technological process. Test shows that forsythin as the active component of the present invention has excellent effect of clearing away hydroxy radical and can inhibit the oxidizing damage in tissue and cell organ level. The medicine of the present invention has also functions of delaying senility and reducing blood fat, etc.

The invention provides a structure of compounds shown in a formula I, a preparation method, and use of pharmaceutically acceptable salts or a mixture thereof in preparation of medicines for preventing and/or treating diabetic complication. The compounds as an aldose reductase inhibitor and an antioxidant effectively eliminate free radicals and inhibit generation of lipid peroxide by inhibiting the activity of aldose reductase so as to play a role of preventing and/or treating diabetic complication. The invention further provides pharmaceutical compositions which comprise the compounds and play a role of preventing and/or treating diabetic complication. The formulae are shown in the description.

The invention discloses a feed additive for producing eggs rich in n-3 series polyunsaturated fatty acid composition. The feed additive adopts an optimized proportion combination by adopting a principle of various plant source function complementation, is added into formula feeds for layer chickens with a ratio of 16 percent, and is used for producing health-care eggs with low cost, safe quality, n-3 series polyunsaturated fatty acid composition enrichment, favorable antioxidant properties, storage stability and easy popularization and application. Compared with ordinary chicken feeds, the feed additive formula enables the n-3PUFA content of a produced egg to be enhanced by 4.01 times to 4.72 times, the level of lipid peroxide (MDA) to be lowered by 20.8 percent to 27.5 percent, and the color of a egg yolk is deepened by 2.1 to 2.4 unit levels (a standard solor fan) when being used for feeding layer chickens. In addition, because added plant resources fulfill has certain efficacy of disease resistance, the feed additive has remarkable effect of nutritional immunity, and the incidence of non-viral diseases of the layer chicken is obviously lowered in a feeding process.

The invention discloses the usage of an ocean collagen peptide preparing for making into antioxidant drugs, antioxidant health food, antioxidant food or antioxidant cosmetics. The products of the ocean collagen peptide have the characteristics of easy absorption, rapid absorption, low viscosity, perfect water-solubility and the like. Animal experiments show that the vitality of antioxidant enzymes is markedly strengthened by providing the ocean collagen peptide for a bandicoot, the content of overoxidation lipoid is reduced, and the invention has the effect of oxidation resistance. Clinical experiments also prove that through oral administration of the ocean collagen peptide, the activity of the antioxidant enzymes of human body can be reduced, generation of lipoid peroxide can be reduced, thereby having the function of oxidation resistance, and facial chloasmata and the like can be dispelled.

The invention relates to a health-care product for enhancing the antioxidation of human bodies, which comprises the following components in part by weight: 50 to 200 parts of ginseng extract, 40 to 250 parts of epimedium extract, 80 to 400 parts of medlar extract and 45 to 300 parts of manyprickle acanto-panax root. The invention also relates to a method for preparing the health-care product for enhancing the antioxidation of the human bodies. The health-care product is a Chinese medicinal preparation, and can improve the measurement of superoxide dismutase and glutathione oxide enzyme obvious, reduce peroxidation lipid content obviously, enhance the oxidation resistance of organisms, conduct a function of delaying aging and reduce various diseases due to presenility of the organisms.

The invention discloses an application of Chinese angelica polypeptide with effects of resisting oxidization and delaying ageing in preparation of food, particularly of health food, and further discloses a preparation method of the Chinese angelica polypeptide. The preparation method is simple and easy to implement, safe and non-toxic, stable and efficient, and is suitable for industrial production. In vitro, the Chinese angelica polypeptide has a characteristic of a certain hydroxyl radical clearance rate, which means that the Chinese angelica polypeptide has capacity of clearing active oxygen; at an integral animal level, an oxidative stress model and an ageing-associated model are used to perform a test, the test result discloses that the survival time of caenorhabditis elegans under an oxidative stress condition can be remarkably prolonged, the lipofuscin level in the caenorhabditis elegans is reduced, average lifetime of the caenorhabditis elegans is prolonged; under the oxidative stress condition and the ageing condition, the Chinese angelica polypeptide can be used for realizing remarkable anti-oxidization and ageing delaying effects by lowering the reactive oxide species (ROS) in vivo and lowering the content of lipid peroxide.

The invention discloses a moisturizing skin-care formulation containing complex polysaccharides and a preparation method of the formulation. The moisturizing skin-care formulation containing complex polysaccharides is made from the following raw materials in parts by weight: 0.2-0.8 of Polygonatum odoratum polysaccharides, 0.1-0.5 of algal polysaccharides, 0.1-0.5 of oat polysaccharides, 10-15 of oil and fat, 1-2 of a first emulsifier, 7-9 of a second emulsifier and 75-80 of water. The study proves that the moisturizing skin-care formulation containing complex polysaccharides has a certain antioxidant activity and can scavenge free radicals and reduce production of lipid peroxides. Therefore, the skin-care formulation containing complex polysaccharides is favorable to slowing skin aging and keeping the skin surface moisturized and has a certain effect of whitening the skin.

The invention discloses preparation of a soybean anti-fatigue biological active peptide, belonging to an extraction processing technology of plant protein. The method comprises the following steps: adding water in high-denaturation soybean meal serving as a raw material to prepare a mixed solution; performing ultrasonic preprocessing on the mixed solution; adding neutral protease into the processed mixed solution to perform enzymolysis so as to obtain enzymatic hydrolysate; performing ultrafiltration treatment on the enzymatic hydrolysate by using a membrane separation technology after the enzymolysis to obtain biological active peptide with high peptide content and molecular weight of less than 5 kDa; then performing separation and purification by using anion exchange chromatography and reversed-phase high-performance liquid chromatography; and finally performing freeze drying to obtain the soybean anti-fatigue biological active peptide. The soybean anti-fatigue biological active peptide prepared by the preparation method disclosed by the invention has higher autioxidant enzyme activities and lower malondialdehyde (MDA) content after movement of a mouse; and results show that the soybean peptide has the functions of reducing cell injury caused by lipid oxidation to have an anti-fatigue effect by removing free radicals produced in the body and inhibiting the generation of lipid peroxides.

The invention discloses a pure natural sweet potato beverage in original color and taste, which belongs to the field of food production process. The beverage is made from purple sweet potatoes as raw material, the process includes enzymolyzing purple sweet potato residue, preserving nutrients and color, flavoring, executing non-thermal sterilization treatment with a rare earth ultrasonic transducer, and packaging. According to the invention, the natural purple potato and the baking purple potato are used for providing natural flavor of the beverage, amylases and pectase are used to digest starch to provide a part of the sweet taste, and a large amount of nutrients such as antioxidants, multiple amino-acids or the like are preserved by maximum in the whole treatment process. The sweet red wine has bright color, fragrance special for purple sweet potato, slightly sweet taste, pure mouth feeling, long aftertaste, without sediment or cloudiness, which is suitable for long-term storage, and convenient for taking. The wine has functions of blood circulation promotion, fatigue recovering, obesity prevention and treatment, gastrointestinal function improvement, skin moistening or the like, is capable of suppressing generation of lipid peroxide, preventing human body aging, and has relative great cancer prevention effect.

The invention discloses eye drops containing vitamin E derivatives and a preparation method thereof. The eye drops comprise main components of water soluble vitamin E derivatives, a thickening agent, a pH regulator, an isotonic agent and water for injection. The eye drops are mainly used for treating dry eye syndrome, and active pharmacological components can be added according to the need and are used for adjuvant treatment of cataract, retinopathy, macular degeneration, keratitis, conjunctivitis and other various ocular diseases. The eye drops have good effects of moisturizing and lubricating, have antioxidation function, can inhibit lipid peroxide reactions in eyes, have effects of expanding peripheral blood vessels, improving blood circulation, protecting, and accelerating injuries to heal, and have good curative effects on various ocular diseases.

The present invention relates to monitoring of oxidative metabolism and is, particularly, directed to a method for the estimation of lipid peroxide load or the consequent inflammatory state of a subject by measuring the concentration of oxidized HDL lipids of said subject. In addition, the invention is also directed to methods for elimination of lipid peroxidation products, and attenuation of the resulting oxidative stress and inflammatory state in human body, by increasing the lipid peroxide transporting capacity of HDL.

The invention discloses an antioxidant and body-building beauty healthcare biscuit belonging to a healthcare food. The antioxidant and body-building beauty healthcare biscuit contains the following components which are measured by grams and shown in a table. The food is prepared for the subhealth crowd to eat, inhibits free radicals, prevents in-vivo lipid peroxide from generating, stimulates themetabolism of human bodies, delays the aging of the human bodies, improves the liver functions, has the efficacy for supplementing endurance, energy and physical strength, stimulating hormone, lowering blood pressure, and the like and integrates functions, convenience, recreation, and the like into a whole.

A dermatological composition containing an association of peroxidized lipids; and zinc in mineral form or zinc compound compatible with dermatological use, formulated for topical application on the skin or the mucous membranes, is disclosed compatible with dermatological use. The composition may be used as a medical device to assist in healing and/or reconstitution of a damaged epidermis and/or to act as an analgesic agent on the skin or the mucous membranes, in particular in the treatment of the symptoms of herpes, pruritus, itching, irritations, eczema, burns, and most particularly in the treatment of labial or genital herpes.

The invention provides a teenager anti-fatigue functional fruit vinegar beverage and a preparation method thereof. Pomelo flesh, green rice and tartary buckwheat bran are subjected to pretreatment, mixing, alcoholic fermentation, acetic fermentation, post-ripening, blending and sterilization filling. The fruit vinegar beverage made from fruit juice is rich in sugar, protein, amino acids and othernutrient contents, enough energy can be provided for teenagers, and organism growth and development are promoted; and the green rice and the tartary buckwheat bran in raw materials are rich in bioactive selenium, flavone, vitamins and other antioxidant contents, metabolites accumulated in bodies of the teenagers can be quickly removed, decomposition of lipid peroxides is accelerated, and the roleof eliminating fatigue is played. Low temperature alcoholic fermentation is adopted, lactobacillus and clostridium kluyveri are added at the later stage of fermentation, the contents of non-volatile acids and esters are increased, and the flavor of the fruit vinegar beverage is boosted; and meanwhile, oligomerization isomaltose is added, proliferation of probiotics in intestinal tracts of the teenagers is promoted, the contents of the vitamins are increased, and the organism immunity is improved.

The invention provides the structure and synthesis method of a compound shown in the formula I, and application of pharmaceutically acceptable salts of the compound or a mixture of the salts in preparation of drugs for preventing and/or treating diabetic complications. The compound acts as aldose reductase inhibitors and antioxidants and can effectively scavenge free radicals and inhibit the production of lipid peroxides by inhibiting the activity of aldose reductase, and thus the effect of preventing and/or treating the diabetic complications is achieved. The invention further provides a pharmaceutical composition containing the compound and having preventive and/or therapeutic effects on diabetic complications. The formula can be seen in the description.

The invention provides a structure and preparation of a quinoxalinone derivative (a compound as shown in formula I) and application of the pharmaceutically acceptable salt of the quinoxalinone derivative in the preparation of drugs for preventing and/or treating diabetic complication. The quinoxalinone derivative serving as a aldose reductase inhibitor and antioxidant can prevent and/or treat thediabetic complication by inhibiting the activity of aldose reductase and effectively scavenging free radicals and lipid peroxide and inhibiting active oxygen at the same time.

The invention relates to a preparation method of special coating resin composition for polyethylene. The preparation method comprises the following steps of: adding a peroxide crosslinking agent accounting for 0.001-0.5% of low-density polyethylene into the low-density polyethylene, and mixing and granulating to prepare the coating resin for the polyethylene, wherein the peroxide crosslinking agent consists of alkyl peroxide, lipid peroxide, diacyl peroxide and hydroperoxide, each of which accounts for 55-85%/5-15%/5-15%/5-15% according to the percentage by weight; the extrusion temperature of an extrusion machine is 150-250 DEG C, and the rotating speed of a screw is 20-60r/min; and the MFR (Melt Flow Rate) of the low-density polyethylene is 5.0-10.0g/10min, and the density is 0.915-0.925g/cm<3>. The special coating resin composition has the characteristics of high strength, good toughness, strong adhesive force and uniform filing forming and the like and is mainly used for surface coating, paper-plastic lamination, a bonding layer and film lamination of plastic woven bags.