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69 results about "Shogaol" patented technology

Shogaols are pungent constituents of ginger similar in chemical structure to gingerol. The most common of the group is (6)-shogaol. Like zingerone, it is produced when ginger is dried or cooked. Moreover, shogaol (and gingerol) are converted to other constituents when heat is applied over time, which is why ginger loses its spiciness as it is cooked.

Ginger extract for the protection of stem cells

Summary Suggested is a ginger extract, comprising (a) 25 to 30 % b.w. [6]-gingerol (b) 5 to 10 % b.w. [8]-gingerol (c) 5 to 10 % b.w. [10]-gingerol (d) 1.5 to 4 % b.w. [6]-shogaol (e) 0.3 to 1.3 % b.w. [8]-shogaol; (f) 0.03 to 1 % b.w. [10]-shogaol; (g) 0.01 to 1 % b.w. zingerone, on condition that the amount of gingerols sums up to 35 to 50 % b.w. and the amount of shogaols sums up to 1.5 to 6 % b.w.
Owner:SYMRISE GMBH & CO KG

Emulsion composition and wet tissue applying emulsion composition

The invention discloses an emulsion composition which comprises a cold sensitizer, a heat sensitizer and water, wherein the mass ratio of the cold sensitizer to the heat sensitizer is 1:0.01-100; the cold sensitizer comprises at least one of piperitol, menthyl lactate, hexa-carbon cyclic amide derivative, non-carbon cyclic amide derivative, mint raw oil, mint oil, mint essence, mint leaf extract, water-soluble menthol and water-soluble mint oil; and the heat sensitizer comprises at least one of vanillyl butyl ether, citronellol n-propyl ether, citronellol isopropyl ether, citronellol isobutyl ether, citronellol n-amino ether, citronellol isoamyl ether, citronellol n-hexyl ether, citronellol methyl ether, citronellol ether, gingerol, shogaol, zingerone, capsaicin and capsaicine. According to the emulsion composition and a wet tissue applying emulsion composition, the preparation process is simple, and the cost is low; a plurality of feeling organs of the skin of a human body can be simulated; and compared with a product which only stimulates a single feeling organ of the human body, the emulsion composition has relatively long refreshing time.
Owner:GOLD HONG YE PAPER

Method for preparing 6-shogaol

The invention relates to the field of natural medicines, in particular to a method for preparing 6-shogaol, which is a method for preparing the efficient component 6-shogaol from the extract of ginger supercritical fluid. The method comprises the following steps of: mixing the extract of ginger supercritical fluid with an ethanol-containing acid water liquid before conversion, heating and refluxing, then separating and refining. The content of the 6-shogaol in the original extract of ginger supercritical fluid is about 2.5%, and the content of the 6-shogaol in the extract after the acid waterreaction can reach 20%.
Owner:CHINA PHARM UNIV

Environment-friendly marine antifouling coating

InactiveCN103788811AEffectively inhibits adhesionAdhesion failureAntifouling/underwater paintsPaints with biocidesCapsaicinSolvent
The invention discloses an environment-friendly marine antifouling coating which comprises the following raw materials in parts by weight: 20-45 parts of epoxy phenolic resin, 0.5-1 part of titanium dioxide, 1-10 parts of a biological antifouling agent, 5-10 parts of titanium white, 3-8 parts of kaolin, 8-15 parts of mica powder, 18-28 parts of a solvent, 0.05-1 part of an anti-settling agent and 0.05-1 part of a wetting dispersant. Capsaicine in the biological antifouling agent has a very good avoidance effect on marine organisms; sodium benzoate and gallotannic acid have effective adhesion inhibition effects on barnacles and have paralyzing effects on beetles; shogaol has a very good adhesion prevention effect on mussels and cannot injure mussels, and the adhesion prevention effect of the shogaol is 4 times that of copper sulfate; P-cinnamic acid sulfate has a very good adhesion inhibition effect on marine bacteria and the barnacles, cannot cause any injury to the marine organisms, and is pure natural and pollution-free.
Owner:QINGDAO ADVANCED MARINE MATERIAL TECH

Synthesis process of gingerol derivative

The invention relates to a synthesis process of a gingerol derivative. A shogaol derivative is obtained by condensation of vanillin, aliphatic aldehyde and ketone in acid and base solvents in an appropriate ratio. The novel gingerol derivative is obtained by catalytic hydrogenation reduction of shogaol. The synthesis process disclosed by the invention is simple, and the gingerol derivative can be obtained through the reaction with one step-two steps and through a simple and convenient purification method.
Owner:朱志成

Method for extracting sun choke essential oil and sun choke brain by enzymolysis-vapor distillation process

The enzymolysis-water vapor distillation process of extracting kaempferia galanga oil and shogaol includes the following steps: sorting, cleaning and crushing kaempferia galanga into grains of 0.1-3 mm size; enzymolyzing slurry at 50-100 deg.c and solid / liquid ratio of 1 / 3 to 1 with amylase for in concentration of 0.2-2.0 % 30-150 min; water vapor distillation in solid / liquid ratio of 1 / 7-1 / 3 for 3-7 hr, with water vapor amount being 200-700 g / hr each 100 g sandgingar; and oil-water separating or filtering to obtain kaempferia galanga oil and shogaol. The present invention can obtain clear and transparent kaempferia galanga oil.
Owner:GUANGZHOU UNIVERSITY

Compound medicinal composition for treating acute lymphocytic leukemia

The invention relates to the field of natural medicaments, and discloses a compound medicinal composition for treating acute lymphocytic leukemia. The compound medicinal composition is characterized by containing 6-shogaol and Salubrinal. The composition of the 6-shogaol and the Salubrinal can generate biological effect of high-dose 6-shogaol at low-dose compatibility so as to greatly reduce the clinical use dose of the 6-shogaol, reduce potential toxic or side effect, improve safety indexes of clinical treatment and obtain good clinical medicament development prospect.
Owner:CHINA PHARM UNIV

Pharmaceutical composition containing ginger extract or shogaol

ActiveCN102215857AImprovement or reduction of learning disabilitiesImprovement or alleviation of memory impairmentNervous disorderKetone active ingredientsDiseaseMemory disorder
The present invention provides a pharmaceutical composition for preventing or treating learning disabilities, memory disorders, Parkinson's disease, or ischemic cerebrovascular disease, wherein said pharmaceutical composition contains ginger extract or shogaol and a pharmaceutically allowable carrier. Further, the present invention provides a food composition for improving or alleviating learning disabilities or memory disorders, or a food composition for improving learning ability and memory, containing ginger extract or shogaol as active ingredients.
Owner:UNIV IND COOP GRP OF KYUNG HEE UNIV

Medical application of natural product 6-shogaol in enhancing chemosensitivity of pancreatic cancer on gemcitabine and compound drug composite of natural product 6-shogaol

The invention relates to the field of natural drugs, and discloses medical application of natural product 6-shogaol in enhancing the chemosensitivity of pancreatic cancer on gemcitabine and a compound drug composite of the natural product 6-shogaol. According to the invention, low-dose gemcitabine can generate biological effect under high dose through the combined administration of the 6-shogaol and the gemcitabine, so that the clinical usage amount of the gemcitabine can be greatly reduced, the toxic side effect can be reduced, the clinical treatment safety index can be enhanced, and good clinical application development prospect is achieved.
Owner:CHINA PHARM UNIV

A preparation method of shogaol extract and its medical application

The invention relates to the field of natural medicines, in particular to a preparation method of 6-shogaol extract and its medical application. Ginger supercritical fluid extract or dried ginger extract is extracted by heating reflux with ethanol-containing acid water, recovering ethanol, extracting the acid water solution with ethyl acetate, recovering ethyl acetate under reduced pressure to obtain a concentrate after extraction, and passing the concentrate through silica gel chromatography Column, gradient elution with petroleum ether and ethyl acetate, collecting the eluate and concentrating to obtain that, wherein the petroleum ether and ethyl acetate used for elution are eluted in six gradients, and the volume ratios are: 50:1, 33 :1, 25:1, 20:1, 17:1, 14:1, the 14:1 fractions were collected and concentrated. The preparation method of the present invention is easy to operate, the quality of the finished product is good, and the output is high. It only needs to be separated by silica gel column chromatography once after conversion to obtain the zingiberene phenolic composition, and the yield is very high, which can reach 60-65%, which is industrial production Bring great convenience.
Owner:CHINA PHARM UNIV

Processing method for fresh ginger

The invention discloses a processing method for fresh ginger. The processing method comprises the following steps that (1) cleansing is conducted, specifically, a fresh ginger raw material is taken, silt is washed away, and impurities are removed; (2) air is discharged, specifically, the cleansed fresh ginger is transferred into a steamer, and air and steam in the steamer are discharged; (3) closed steaming is conducted, specifically, the fresh ginger is subjected to closed steaming through the closed and air-discharged steamer under 100-130 DEG C for 2-4 h; (4) stewing is conducted, specifically, after closed steaming is completed, closed stewing is kept, the fresh ginger is naturally cooled, and then the steamer is opened; and (5) drying is conducted, specifically, the stewed fresh ginger is dried, and moisture is controlled to be 6%-13%. Through the specific fresh ginger processing method and technological parameters, dissolution of beneficial components in the fresh ginger is facilitated, the total content of gingerol is increased, gingerol components are promoted to be converted into shogaol components, the total content of shogaol is increased, the contents of water-soluble extracts and volatile oil are greatly increased, and meanwhile the color of a product is protected, so that the color appearance of the product is more excellent.
Owner:CHENGDU INST OF CHINESE HERBAL MEDICINE

Process for producing shogaols and intermediates for the synthesis thereof

In accordance with the invention, an industrial process for producing shogaols useful in the fields of for example foods, flavor, pharmaceutical products, qui-pharmaceutical products and cosmetics can be provided. The invention relates to novel intermediates represented by the following general formula and a process for producing shogaols from the intermediates. In accordance with the invention, shogaols can readily be produced, of which mass production has been difficult because shogaols have been produced only by the extraction process from a natural ginger. Intermediates; (in the formula (1), R1 represents hydrogen atom or methyl group; R2 represents optionally branched alkyl group with one to 18 carbon atoms; R3 and R4 each independently represents hydrogen atom, a lower alkyl group or a protective group of the phenolic hydroxyl group; A represents an alkylene group with one to 4 carbon atoms; and X represents benzenesulfonyl group or toluenesulfonyl group.)
Owner:TOAGOSEI CO LTD

Pharmaceutical composition comprising ginger extract or shogaol

The present invention provides a pharmaceutical composition for preventing or treating learning disorders, memory disorders, Parkinson's disease, or ischemic cerebrovascular disease, which comprises a ginger extract or shogaol; and a pharmaceutically acceptable carrier. And also, the present invention provides a food composition for improving learning disorders or memory disorders or alleviating the symptoms of learning disorders or memory disorders which comprises a ginger extract or shogaol as an active ingredient, or a food composition for improving learning or memory which comprises a ginger extract or shogaol as an active ingredient.
Owner:UNIV IND COOP GRP OF KYUNG HEE UNIV

Effective part of small Pinellia ternate decoction, preparation method thereof and application thereof

InactiveCN102552850AReduce vomitingSignificant antiemetic activityDigestive systemPlant ingredientsMouse StomachShogaol
The invention discloses an effective part of a small Pinellia ternate decoction. The effective part has the following physical and chemical properties: the effective part is a yellow oily substance, and the effective part which has certain volatility can be dissolved in hot water and ethanol; and the effective part which mainly contains gingerol and shogaol components concretely contains 40-50% of 6-gingerol and 12-20% of 6-shogaol. The invention also discloses a preparation method and an application of the effective part of the small Pinellia ternate decoction. The fat-soluble effective partextracted from the small Pinellia ternate decoction has the following obvious pharmacological drug effects: 1, the vomiting prevention effect is obvious, results of experiments of pigeon vomiting caused by copper sulfate and a chemotherapeutic cis-platinum as experiment models show that the fat-soluble part has a substantial vomiting prevention activity and can obviously reduce the vomiting frequency of pigeons; and 2, the effective part has a normal mouse stomach evacuation inhibition effect.
Owner:NANJING UNIVERSITY OF TRADITIONAL CHINESE MEDICINE

Method for continuously extracting and purifying ginger polyphenol

The invention discloses a method for continuously extracting and purifying ginger polyphenol. According to the method, firstly, the ginger polyphenol is extracted in a combined way by an enzyme-ultrasound method; after the purification by an ultra-pure method, AB-8 macroporous resin adsorption is performed; then, a polyamide column, a silicon gel column and a Sephadex LH-20 gel column are continuously used for chromatography purification; the sample is subjected to freeze drying to obtain a purified sample. The maximum absorption wavelength of the polyphenol obtained from the ginger polyphenolpurified sample prepared by the method through UV scanning and CG-MS analysis is 281 nm; the result of the CG-MS analysis proves that the purified materials mainly contains 66.38 percent of 6-gingerol, 3.12 percent of 8-gingerol, 2.06 percent of Z-6-shogaol, 1.93 percent of 8-shogaol, 2.53 percent of citral and 9.35 percent of capraldehyde (heating degrading products of shogaol). The purity of the ginger polyphenol prepared by the method is as high as 85.37 percent.
Owner:SHANDONG AGRICULTURAL UNIVERSITY

Use of aframomum melegueta and method for extracting and separating 6-shogaol from aframomum melegueta

The invention provides a use of aframomum melegueta and a method for extracting and separating 6-shogaol from aframomum melegueta, and particularly relates to the use of aframomum melegueta for extraction of 6-shogaol. The method comprises the following steps: crushing the raw material aframomum melegueta, and adopting subcritical extraction, to obtain an oil extract; dissolving the oil extract by ethanol, then extracting by a solvent, and concentrating to an extract; adopting column separation, according to thin layer spots, collecting an eluate containing 6-shogaol, concentrating, and placing to crystallize; dissolving the crystal by an organic solvent, concentrating, then filtering the crystal, and drying to obtain 6-shogaol. The use of the aframomum melegueta for extraction of 6-shogaol is provided, the content of 6-shogaol in the aframomum melegueta raw material is multiple times higher than the content of 6-shogaol in a raw ginger raw material, the content of 6-shogaol in the aframomum melegueta raw material is 0.30%-0.42%, and the content of 6-shogaol in the raw ginger raw material is reported to be 0.005%; the obtained product has the advantages of high yield, stability and low cost.
Owner:陕西嘉禾药业有限公司

Microtubule-disruptng agent and cancer cell proliferation inhibitor containing the same

InactiveUS20100286283A1Stopping cell divisionCell viability inhibitedBiocideOrganic chemistryDepressantShogaol
The present invention provides a novel microtubule-disrupting agent, and also provides a use of the microtubule-disrupting agent. A microtubule-disrupting agent containing an α,β-unsaturated carbonyl compound as an active ingredient is provided. Further, a cancer cell proliferation inhibitor containing the microtubule-disrupting agent is also provided. As the α,β-unsaturated carbonyl compound, 6-shogaol is preferably used.
Owner:NAGOYA UNIVERSITY

Extraction and purification method for 6-shogaol

The invention provides an extraction and purification method for 6-shogaol. The method comprises the following steps: taking fresh ginger and rhizoma zingiberis as raw materials; chopping the raw materials or adopting 70% ethyl alcohol for digesting in a 40-55 DEG C water bath after crushing; filtering drug residue and then performing reduced pressure distillation on the extracting liquid, thereby acquiring a concentrated solution; removing impurities by extracting the concentrated solution with petroleum ether and extracting 6-shogaol component by using ethyl acetate; after removing the solvent from the extracting liquid, performing chromatography with silica gel on the ethyl acetate extract part, adopting petroleum ether and ethyl acetate at ratio of (6:1)-(2:1) for performing gradient elution, separating and collecting the component of Rf=0.38 (petroleum ether and ethyl acetate at ratio of (3:1), thus obtaining the separated crude product of 6-shogaol; further thinning and performing chromatographic separation on the crude product of 6-shogaol, thereby acquiring pure product of 6-shogaol and representing the pure product with 1HNMR and 13CNMR. The method is simple in operation, the material cost is low, the time is saved and the purity is high. The acquired 6-shogaol product can be used as a standard product for quality control on the pharmaceutical preparation containing ginger and shogaol, pharmacological research, cosmetics, daily chemical products, and the like.
Owner:CHONGQING UNIV

Quality control method for dried ginger

The invention discloses a quality control method for dried ginger. The method comprises the following steps of: determining the content of 4 ginger phenolic chemical components including 6-gingerol, 8-gingerol, 6-shogaol and 10 gingerol, and 2 volatile oil chemical components including alpha-curcumene and (E)-beta-farnesene in the dried ginger medicinal materials by adopting an HPLC-PDA method; and taking the total amount of the ginger phenolic components, the total amount of the volatile oil components, or the total amount of the ginger phenolic components and the volatile oil components as an evaluation index, which is used for formulating a standard for evaluating the quality of the dried ginger medicinal material and controlling the quality. The method is capable of comprehensively, objectively and effectively evaluating the quality of the dried ginger medicinal material by simultaneously detecting two types of the active ingredients of the dried ginger medicinal material and analyzing the fingerprint spectrum and comparing with a single analysis of one or a class of chemical components, and is used for the quality control thereof, and the method is simple and convenient to operate, good in stability and easy to be popularized.
Owner:NANJING UNIVERSITY OF TRADITIONAL CHINESE MEDICINE

Separating and purifying method for shogaol

The shogaol separating and purifying process includes the following steps: 1. separating water, Kaempferia galanga oil and shogaol in the distilled mixture, and filtering to obtain coarse shogaol crystal; 2. adding alcohol or acetone in 1-3 times the weight of coarse shogaol crystal into the coarse shogaol crystal and adding distilled water in 15-35 times the weight; 3. regulating pH value of the solution to 4-8, setting for 20-40 hr to separate crystal; and 4. filtering and vacuum drying to obtain high purity shogaol crystal. The product is used in medicine.
Owner:GUANGZHOU UNIVERSITY

Marine antifouling nano paint

The invention discloses a marine antifouling nano paint, which is prepared from the following raw materials: epoxy phenolic resin, titanium dioxide, a nano biological antifouling agent, filler, an acetic acid, and glyceryl tristearate. Capsaicin in the nano-scale biological antifouling agent has a good approach-avoidance effect on marine organisms; tannic acid has an adhesion inhibition effect on barnacle and also has a paralysis function on the beetle; shogaol has strong ability of preventing adhesive ability of mussel. P-cinnamic acid sulfate has a strong adhesion inhibition effect on marine bacteria and barnacle, homarine can prevent adhesion of marine benthic diatom and barnacle, and diterpenes formamide has an effect of inhibiting the barnacle and shellfish larvae. The paint disclosed by the invention comprises a nano-scale pure natural biological antifouling agent, has the approach-avoidance effect on marine organisms, and destroys the adhesive ability of the marine organisms, so as to achieve the target of preventing and treating pollution. The marine antifouling nano paint does not generate any deleterious effect on the marine environment, is free of an injury to the marine organisms, and is purely natural and harmless.
Owner:QINGDAO ADVANCED MARINE MATERIAL TECH

Dried ginger quality evaluation method based on UPLC-TQ-MS/MS

The invention relates to a dried ginger quality evaluation method based on UPLC-TQ-MS / MS. According to the invention, the difference mark component 6-gingesulfonic acid before and after dry ginger smoking is compared with nine compounds (6-gingerol, 6-shogaol, 6-dehydrozingiberendione, 8-gingerol, 8-shogaol, 8-dehydrozingiberendione, 10-gingerol and 10-shogaol) which are mainly contained in other dry ginger, have remarkable biological activity and cover multiple types of structures; meanwhile, a UPLC-TQ-MS / MS mass analysis method is constructed, so that the stoving dried ginger and the non-stoving dried ginger can be quickly distinguished by one analysis method, and meanwhile, the quality level of the dried ginger is quantitatively evaluated. The method is high in specificity, accurate and reliable, provides technical support for safe use and stable quality of dried ginger, and provides a referential research method for quality evaluation of traditional Chinese medicinal materials / stoving traditional Chinese medicinal materials.
Owner:JINAN UNIVERSITY

Process for producing shogaols and intermediates for the synthesis thereof

In accordance with the invention, an industrial process for producing shogaols useful in the fields of for example foods, flavor, pharmaceutical products, qui-pharmaceutical products and cosmetics can be provided. The invention relates to novel intermediates represented by the following general formula and a process for producing shogaols from the intermediates. In accordance with the invention, shogaols can readily be produced, of which mass production has been difficult because shogaols have been produced only by the extraction process from a natural ginger.Intermediates;(in the formula (1), R1 represents hydrogen atom or methyl group; R2 represents optionally branched alkyl group with one to 18 carbon atoms; R3 and R4 each independently represents hydrogen atom, a lower alkyl group or a protective group of the phenolic hydroxyl group; A represents an alkylene group with one to 4 carbon atoms; and X represents benzenesulfonyl group or toluenesulfonyl group.)
Owner:TOAGOSEI CO LTD

Method for preparing 6-shogaol

The invention relates to the field of natural medicines, in particular to a method for preparing 6-shogaol, which is a method for preparing the efficient component 6-shogaol from the extract of ginger supercritical fluid. The method comprises the following steps of: mixing the extract of ginger supercritical fluid with an ethanol-containing acid water liquid before conversion, heating and refluxing, then separating and refining. The content of the 6-shogaol in the original extract of ginger supercritical fluid is about 2.5%, and the content of the 6-shogaol in the extract after the acid waterreaction can reach 20%.
Owner:CHINA PHARM UNIV
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