21 results about "Shogaol" patented technology

The invention belongs to the technical field of plant care essential oil extraction, and particularly relates to sanshool delayed care essential oil and a preparation method thereof. The invention discloses a sanshool-enriched lipid composition which is prepared from the following components in parts by weight: 0.05 to 0.1 part of sanshool-enriched fraction, 1 to 2 parts of solid lipid, 1 to 1.5 parts of liquid lipid, 1.5 to 2.5 parts of stable surfactant, 1 to 2 parts of cosurfactant, 3 to 5 parts of glycerol, 0.2 to 0.5 part of soothing anti-irritation component, 0.05 to 0.1 part of sodium hyaluronate, 0.1 to 0.3 part of hydroxypropyl methyl cellulose, 0.05 to 0.1 part of antioxidant and the balance of purified water. According to the invention, sanshool is used as a core functional factor, and through collaborative design of supercritical extraction, molecular distillation purification, NLC carrier encapsulation and a soothing film-forming system, contradictions of effectiveness, mildness and the like in an existing scheme are solved, and mild desensitization, stable controlled release, reduction of stimulation and migration risks and improvement of tolerance and action consistency are realized.

Methods of making bioactive compound-loaded nanoparticles are provided. The methods harness naturally-occurring biopolymers to produce nanoparticles from raw plant materials. Methods include contacting plant-derived materials with alkaline solution with agitation to deprotonate the bioactive materials and biopolymers to form nanoparticles. In some forms, the methods contact the nanoparticle with an acid to re-protonate the components and more stable nanoparticles. The bioactive compounds can be extracted from raw plants and / or plant parts, including turmeric, ginger, clove, thyme, pepper, and rosemary. The bioactive compounds include curcumin, gingerols, shogaols, eugenol, thymol, carvacrol, capsaicin, and rosmarinic acid. Compositions and formulations containing bioactive-compound loaded nanoparticles are also provided.

This invention relates to the formula and process of making cookies based on sorghum flour (Sorghum bicolor L. Moench) with the addition of red ginger powder (Zingiber officinale var. rubrum) as a gluten-free functional food based on local Indonesian raw materials. The developed formula consists of sorghum flour as the main ingredient, red ginger powder, margarine, brown sugar, chicken eggs, and salt. This product inherently contains the bioactive compounds gingerol and shogaol from red ginger as natural added value, making it an alternative gluten-free cookie with functional value based on local resources.

The invention discloses a hydroxyl-alpha-sanshool nano preparation as well as a preparation method and application thereof, and belongs to the technical field of pharmaceutical preparations, the hydroxyl-alpha-sanshool nano preparation is HAS-coated PEG-PLGA, the preparation method comprises the following steps: taking hydroxyl-alpha-sanshool and polyethylene glycol modified polylactic acid-glycolic acid copolymer as raw materials, and adding the hydroxyl-alpha-sanshool nano preparation and the polyethylene glycol modified polylactic acid-glycolic acid copolymer to prepare the hydroxyl-alpha-sanshool nano preparation. The preparation method comprises the following steps: preparing HAS-coated TGN-PEG-PLGA by adopting an emulsified solvent evaporation method, and further modifying by adopting TGN polypeptide, so as to prepare HAS-coated TGN-PEG-PLGA; according to the hydroxyl-alpha-sanshool nano-preparation, the encapsulation efficiency and the drug loading capacity of hydroxyl-alpha-sanshool are obviously improved, and the hydroxyl-alpha-sanshool nano-preparation has excellent stability and blood-brain barrier crossing capacity, so that the hydroxyl-alpha-sanshool nano-preparation can give full play to the treatment effects of improving learning and memory ability, cognitive ability and the like.

The invention relates to the technical field of traditional Chinese medicine research, in particular to a quality marker for preventing and treating kidney-yang deficiency of a medicinal and edible formula composition as well as a preparation method and application of the quality marker. The medicinal and edible formula composition is prepared from the following raw materials in parts by weight: 1-2 parts of cortex cinnamomi, 6-8 parts of fructus momordicae, 2-4 parts of pericarpium citri reticulatae, 2-4 parts of rhizoma zingiberis, 8-10 parts of radix ginseng, 29-31 parts of radix astragali, 4-6 parts of radix glycyrrhizae preparata and 14-16 parts of poria cocos. The mass markers comprise [6]-isoshogaol, 3, 5, 6, 7, 8, 3 ', 4'-heptamethoxyl flavone, 1-dehydrogenation-[8]-zingiberendione, 6-methyl zingiberendiol, nobiletin, peterolide and the like. The ginseng formula for regulating the middle warmer is reasonably added and subtracted, so that the traditional Chinese medicine composition is applied to prevention and treatment of the kidney-yang deficiency syndrome, and a new application prospect is given to the classic famous formula. Meanwhile, on the basis of spectrum-effect association research, a quality marker group associated with the kidney-yang deficiency effect is screened and established for the first time, and scientific, accurate, stable and controllable product quality of the medicinal and edible formula composition can be achieved.

The application discloses a medicine composition for inhibiting inflammatory activation of microglial cells and application thereof. 6-gingerol and eucommia alcohol are combined with each other, and the combination has a significant synergistic effect, and can effectively inhibit inflammatory activation of microglial cells.

This invention relates to a method for preparing 6-shogaol from chili peppers. It solves the technical problems of existing 6-shogaol extraction and purification methods, such as large solvent consumption and difficulty in recovery, significant safety hazards, unsuitability for large-scale production, cumbersome processes, long processing times, and low yields. The method of this invention includes the following steps: S1) Extracting and separating chili peppers using a supercritical CO2 method to obtain an oil paste; S2) Dissolving and saponifying with alkaline water, then concentrating to obtain a clear and transparent oil; S3) Performing molecular distillation to obtain a heavy phase component oil; S4) Eluting on a first silica gel column for adsorption, while simultaneously using thin-layer chromatography to detect the eluent, collecting the mixed eluent containing 6-shogaol, and concentrating to obtain a light red oily substance; S5) Eluting on a second silica gel column for adsorption, while simultaneously using thin-layer chromatography to monitor the eluent, collecting the eluent containing only a single point of 6-shogaol, and concentrating to obtain a light yellow oily substance; S6) Dissolving, decolorizing, and crystallizing at low temperature to obtain the 6-shogaol product.

This invention discloses a method for evaluating the quality of Xiaochaihu granules based on 6-gingerol, comprising the following steps: accurately weighing 6-gingerol, dissolving it in a diluent and quantitatively diluting it to prepare a reference solution; taking Xiaochaihu granules, grinding them finely, loading them onto the sample using a dry method and using C... 18 The test solution was prepared by purification using a solid-phase extraction column. The reference solution and the test solution were injected and analyzed under chromatographic conditions. The content of 6-gingerol was calculated using the external standard method to evaluate the quality of Xiaochaihu granules. This method uses a specific solid-phase extraction column to purify the test solution and employs high-performance liquid chromatography (HPLC). This solves the problems of the presence of other medicinal components in Xiaochaihu granules severely interfering with the separation of 6-gingerol from ginger flavor, and the poor thermal stability of 6-gingerol. It achieves quantitative detection of 6-gingerol and has high specificity, thus enabling the addition of new quality standard research for Xiaochaihu granules, ensuring product quality control, and guaranteeing product safety and efficacy.

The present application relates to the use of [10]-shogaol in the preparation of a medicament for preventing and / or treating tumors sensitive to ferroptosis. Specifically, the present application provides a method for screening ferroptosis inducers, comprising the following steps: taking cells sensitive to ferroptosis, applying a candidate compound to a test group, applying [10]-shogaol to a positive control group, applying [6]-shogaol to a non-ferroptosis inducer group, and not applying any compound to a blank control group; detecting the lipid peroxidation level in the cells of each group; comparing the lipid peroxidation levels of the test group and the other groups to detect whether the candidate compound is a ferroptosis inducer. The [10]-shogaol can effectively induce ferroptosis in various malignant tumor cells such as breast cancer, colorectal cancer, melanoma, etc., and the mechanism of action depends on the accumulation of lipid peroxidation, and this effect can be specifically blocked by ferroptosis inhibitors.

The application provides a processing method for directional enrichment of 6-gingerenol through microbial fermentation to enhance the damp dispelling effect of raw ginger and improve the pungent flavor, comprising fermentation treatment of raw ginger; wherein the fermentation strain used in the fermentation treatment comprises at least one of Paracaseolovis LP8082 with the preservation number of GDMCC No. 67814, Lactobacillus plantarum Z1 and Paracaseolovis F1. The processing method for reducing the pungency and enhancing the effect of raw ginger provided by the application can accurately reduce the pungent components of raw ginger, so that 6-gingerol is converted into 6-gingerenol with stronger effect, so as to develop a new type of raw ginger product with clear effects such as perspiration, damp dispelling, anti-inflammatory and immunity enhancement and mild taste, and meet the market demand for high-quality natural and healthy products.

The invention belongs to the technical field of green and efficient extraction of natural active substances, and particularly relates to a method for synchronously realizing efficient extraction of ginger polyphenol from a ginger raw material and conversion of the ginger polyphenol into high-activity substances through a one-step process by completely adopting a natural edible eutectic solvent system of a food-grade raw material. According to the method disclosed by the invention, a deep eutectic solvent system is constructed by selecting two edible natural components, namely monosaccharide or a polyhydroxy compound and organic acid, so that the deep eutectic solvent system has double functions of efficiently dissolving ginger polyphenol substances contained in ginger and mildly catalyzing the conversion of gingerol into shogaol at the same time, thereby realizing the integrated completion of extraction-conversion. According to the method, complex intermediate steps are abandoned, and a one-step process is adopted, so that the process flow is simplified, and product loss or degradation caused by the intermediate steps is effectively avoided. According to the method, extraction and conversion are synchronously carried out, the whole technological process is greatly shortened, energy consumption and equipment requirements are correspondingly reduced, and good economical efficiency is embodied.

The purpose of the present invention is reduce the likelihood that a choking sensation will be experienced when an entire non-carbonated beverage that is sour is drunk all at once.　Shogaol is added to a non-carbonated beverage having an acidity of 0.4% or greater until the shogaol concentration of the beverage is at least 0.02 ppm.

The invention relates to the technical field of quality analysis of Chinese patent medicines, in particular to an establishment method and content determination method of HPLC characteristic chromatograms of related components of bone-strengthening musk analgesic ointment, and the establishment method comprises the following steps: step 1) preparation of a test solution; taking a bone-strengthening musk analgesic paste sample, pre-treating to remove a volatile matrix, adding a solvent, carrying out ultrasonic extraction, fixing the volume, filtering, and taking a subsequent filtrate to obtain a sample solution; 2) preparing a mixed reference substance solution; taking reference substances of aconitine, 4-methoxysalicylaldehyde, cinnamaldehyde, white angelica brain, gingerol, imperatorin and 6-shogaol, and adding methanol to a constant volume to obtain a reference substance stock solution; weighing the reference substance stock solution, and adding methanol to dilute the reference substance stock solution into a mixed reference substance solution; and (3) respectively measuring the sample solution in the step (1) and the mixed reference substance solution in the step (2) by adopting a high performance liquid chromatography, determining a common peak according to the relative retention time of a reference substance, determining a characteristic peak by utilizing a standard substance, and establishing the HPLC characteristic chromatogram of the bone-strengthening musk analgesic paste. The method has the advantages that the precision, the stability and the repeatability are good, the sample adding recovery rate meets the requirement, and the method can be used for actual quality control of the product.

This invention provides a ginger active ingredient composition and its application. The ginger active ingredient composition includes acetylated 12-gingerol, 8-gingereneol, and 10-gingereneol in a mass ratio of (1-3):2:(2-3). The ginger active ingredient composition of this invention can improve glucose tolerance, increase insulin sensitivity, reduce serum triglyceride, total cholesterol, and low-density lipoprotein cholesterol levels, increase high-density lipoprotein levels, reduce the activity of hepatic alanine aminotransferase and aspartate aminotransferase, improve the degree of hepatic fat vacuolar lesions, and reduce the content of lipid metabolism-related metabolites in obese individuals. Simultaneously, acetylation of 12-gingerol improves its lipid solubility, enhances cell membrane penetration, reduces oxidative degradation of phenolic hydroxyl groups, and improves stability. Furthermore, it releases free 12-gingerol after enzymatic hydrolysis, achieving a sustained-release effect.

The invention discloses a method for high-throughput and high-efficiency separation of a hydroxyl sanshool monomer based on two-dimensional chromatography combination, and belongs to the technical field of natural product separation and purification. In order to solve the problem that hydroxyl-epsilon-sanshool, hydroxyl-alpha-sanshool, hydroxyl-beta-sanshool and hydroxyl-gamma-sanshool in the pepper extract, especially cis-trans isomers with highly similar structures, are difficult to separate, the method combines high-speed counter-current chromatography and preparative liquid chromatography in an off-line manner. The method comprises the following steps: firstly, carrying out first-dimensional separation by utilizing high-speed counter-current chromatography to realize high-flux impurity removal so as to obtain a hydroxyl-gamma-sanshool monomer and enrich an isomer mixture; and carrying out second-dimensional high-resolution separation on the mixture by using preparative liquid chromatography so as to synchronously obtain four high-purity hydroxyl sanshool monomers. The method has the advantages of large separation flux, high efficiency, good resolution, high recovery rate and low cost, and provides a reliable technical means for standard substance preparation, deep research and product development of the pepper numb-taste substances.

This invention discloses a 6-shogaol analogue and its derivatives, compositions comprising the same and methods of preparation thereof, as well as methods of using said compounds / compositions to treat diseases or conditions, such as depression.

An object of the present invention is to provide a method for reducing a pungent taste of a food or drink containing 6-shogaol, and further to provide a food or drink containing 6-shogaol having a good taste quality and a method for producing the same.SOLUTION: The pungent taste of food and drink containing 6-shogaol can be reduced by blending limonene and / or menthol with the food and drink containing 6-shogaol.SELECTED DRAWING: None

A method of preparing ginger extract by water and / or alcohol. Said ginger extract contains gingerols (e.g., 6-, 8-, 10-gingerol) and / or shogaols (e.g., 6-, 8-, 10-shogaol), and it can further contain Total Phenolic Contents (TPC) and / or GABA. The compositions containing said ginger extract are used in preparation of anti-inflammatory, antioxidant, antibacterial, analgesic or anti-cancer medicament, etc..

The present invention relates to a sustained release pharmaceutical composition comprising ginger extract. Particularly, this invention relates to sustained release granules of ginger extract wherein the ginger extract contains high payload of gingerols and shogaol. More particularly, the present invention relates to a sustained release granules of ginger extract wherein the granules release the gingerol and shogaols in sustained release manner. The present invention further relates to the process of preparation of ginger extract from ginger rhizome using supercritical fluid extraction wherein the extract is having high payload of gingerols and shogaol.

The invention discloses an application of 6-shogaol in preparation of a medicine for promoting skeletal muscle regeneration and / or repair. The 6-shogaol can activate stationary-stage muscle satellite cells, promote myoblast differentiation and myotube fusion, guide damaged broken end new muscle fiber connection and realize structure repair. Meanwhile, 6-shogaol can inhibit excessive deposition of collagen, reduce scar formation and promote functional regeneration. In the fracture accompanied with muscle injury, the bone healing quality is synergistically enhanced by improving the soft tissue environment and vascularization, new bone formation is increased, and the problem of bone nonunion caused by muscle injury is solved. In a word, the 6-shogaol can solve the pain point that the physical injury of the skeletal muscle is difficult to heal through the dual mechanisms of promoting muscle regeneration and resisting fibrosis, and cooperatively promotes the accompanying bone injury repair. The application is different from conventional osteoporosis treatment or disuse atrophy treatment, and has definite clinical pertinence and application value.

The present invention provides a composition having an action to enhance adrenomedullin gene expression. One or more embodiments of the present invention relate to a composition for enhancing adrenomedullin gene expression containing a TRPV1 agonist and a TRPA1 agonist as active ingredients. The TRPV1 agonist can be, for example, at least one selected from capsaicin, 6-shogaol, 6-gingerol and piperine. The TRPA1 agonist can be, for example, at least one selected from allyl isothiocyanate, cinnamaldehyde, diallyl disulfide, ASP7663 and oxylipin.