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1091results about How to "Short synthetic route" patented technology

Vanadium dioxide intelligent temperature control film and preparation method thereof

The invention relates to a vanadium dioxide intelligent temperature control film and a preparation method thereof. The preparation method comprises the following steps of: uniformly dispersing and dissolving vanadic oxide powder in an organic solvent with weak reductibility by adopting a wet chemical solution method; adding PVP (Polyvinyl Pyrrolidone) or PEG (polyethylene glycol) and a metal salt to prepare a doped VOx film (x is more than 2.0 and less than 2.5); and performing thermal treatment to form a doped porous hypovanadic oxide (VO2) film. In a better embodiment, the preparation method comprises the following steps of: adding polyvinyl pyrrolidone and a wolfram salt into a system consisting of vanadic oxide powder, benzyl alcohol and isopropyl alcohol to prepare a wolfram-doped VOx film; and annealing in hydrogen / argon atmosphere at the temperature 410 DEG C for 3 hours to prepare a wolfram-doped porous VO2 film, wherein the metal-insulator phase-transition temperature of the wolfram-doped porous VO2 film can be adjusted between 30 DEG C and 68 DEG C according to doping amount of wolfram, the penetration rate of a visible light region is 70 percent, the difference between the penetration rate before phase transition and the penetration rate after phase transition at the position of which the wavelength is 2,500 nanometers is 62 percent, 3-4 orders of magnitude of specific resistance is changed, and higher practical value is achieved.
Owner:SHANGHAI INST OF CERAMIC CHEM & TECH CHINESE ACAD OF SCI

Method for preparing artemisinin through arteannuic acid

The invention discloses a method for preparing artemisinin through arteannuic acid. The method comprises the steps that first the arteannuic acid is processed to obtain a dihydroartemisinic acid under the effect of a reducing agent such as sodium borohydride / nickel chloride or a hydrogen / metal catalyst, and then the dihydroartemisinic acid is oxidized into a peroxided dihydroartemisinic acid through peroxide in the presence of the catalyst, and finally the target product artemisinin can be obtained with high yield under the catalyzing of the acid and the effect of oxygen; or a dihydroartemisinic acid derivative can be obtained from the dihydroartemisinic acid based on the protection on carboxyl, and the dihydroartemisinic acid derivative is oxidized into a relevant peroxided dihydroartemisinic acid derivative through the peroxide in the presence of the catalyst, and then the target product artemisinin can be obtained with high yield under the catalyzing of the acid and the effect of the oxygen. Compared with the prior art, the method for preparing the artemisinin through the arteannuic acid has the advantages as follows: the used agent has low cost, and is easy to obtain; the synthetic route is short; the reaction selectivity is high; the preparation process is environmental-friendly; the operation and post-processing are simple; the total yield is high; and the method for preparing artemisinin through the arteannuic acid is applied to industrial production.
Owner:SHANGHAI JIAO TONG UNIV

Method for synthesizing 6-fluoroindole-3-acetonitrile

The invention relates to the synthesis of organic compounds, in particular to a method for synthesizing 6-fluoroindole-3-acetonitrile, which comprises the following steps: step one, synthesis of 6-fluorogramine: blending raw materials of 6-fluoroindole, dimethylamine hydrochloride and paraformaldehyde according to the mol ratio of 1:1-1.5:1-2, mixing the raw materials evenly and then adding the mixture to an organic solvent, stirring continuously the mixture during the reaction, and heating and refluxing the mixture to prepare the 6-fluorogramine for stand by services; and step two, synthesis of the 6-fluoroindole-3-acetonitrile: blending the raw materials of the 6-fluorogramine prepared in the step one and sodium cyanide according to the mol ratio of 1:1-2, mixing the raw materials into the organic solvent, refluxing the mixture and evaporating out the solvent, and extracting an organic layer to obtain the 6-fluoroindole-3-acetonitrile. The method has the advantages that the short synthetic route is short and can be completed in just two steps, the raw materials are readily available, the substitution of the third position of indole is accurate, the control is convenient with low cost, the reaction yield is high, and a prepared high-purity medicament intermediate product is applicable to industrial production.
Owner:大连凯飞精细化工有限公司

Tricarbazole-aromatic amine derivative cavity transmission material and preparation method and application thereof

The invention discloses a tricarbazole-aromatic amine derivative cavity transmission material and a preparation method and application thereof. The tricarbazole-aromatic amine derivative cavity transmission material is a star-like micromolecule compound which uses tricarbazole as the core and uses aromatic amide derivative as a modifying group; a formula structure is shown in a formula I in the attached figure, wherein R is selected from one of C1 to C30 straight and branched alkyl or alkyl chains. The tricarbazole-aromatic amine derivative cavity transmission material has the advantages thatthe synthesis route is simple and short, the price of the reaction raw materials is low, the reaction process is easy to control, the separation is easy, the purity is high, and the yield rate is high; the cavity transfer rate is higher, and the dissolving property is good; especially, when the cavity transmission material is applied to a rovskite solar battery, the excellent photoelectric conversion efficiency is obtained; the novel cavity transmission material with excellent property and low cost can be applied to organic electroluminescent devices, organic solar batteries, perovskite solarbatteries or organic field effect transistor devices, and the important application potential is realized.
Owner:NANJING UNIV OF POSTS & TELECOMM

Preparation method of clobetasol and preparation method of clobetasol propionate

The invention discloses a preparation method of clobetasol and the preparation method of clobetasol propionate. The preparation method of the clobetasol comprises the following steps: by taking a compound I, namely 1,4,9(11)-triene androstane-3,17-diketone as an initial raw material, performing a methylation reaction, a cyan substitution reaction, a siloxy protection reaction, an intramolecular nucleophilic substitution reaction, a bromoepoxy reaction and a fluorination reaction to prepare a compound VII which is clobetasol. The compound VII is subjected to a propyl esterification reaction to prepare a compound VIII which is clobetasol propionate. According to the preparation method disclosed by the invention, since relatively basic initial raw materials which are cheap are used, each step of reaction is relatively easy to implement and high yield is achieved; the operation of multi-step protection and deprotection is simplified; moreover, 21 sites of fluorine are directly arranged in one step during arrangement of a side chain, and multiple steps of reaction for arranging the 21 sites of fluorine in the prior art are directly avoided, so that the synthetic route is greatly shortened, the total yield is increased, the product quality is improved and the production cost is greatly lowered.
Owner:江西赣亮医药原料有限公司
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