13results about "Organic substitution" patented technology

The present invention relates to bis-aminophosphines which are useful as catalysts for the dimerization of alkyl acrylates. Furthermore, the present invention relates to a process for preparing bis-aminophophines, the use of these bis-aminophosphines as catalysts for dimerization reaction of alkyl acrylates and a process for obtaining dimers of alkyl acrylates using bis-aminophosphines as catalyst.

The application provides a method for synthesizing nitrogen-containing heterocyclic aromatic hydrocarbon derivatives through borate-promoted Suzuki coupling reaction, which comprises the following steps: pyridine borate shown in formula I, pyrimidine borate shown in formula II, quinoline borate shown in formula III are used as raw materials, and alkyl halide shown in formula IV is coupled under the action of borate additive, catalyst, ligand and base, so as to correspondingly generate pyridine derivative shown in formula V, pyrimidine derivative shown in formula VI and quinoline derivative shown in formula VII; wherein, R is a substituent group. The method has the advantages of wide raw material source, stable reaction system, wide substrate applicability, mild reaction condition, good reaction functional group compatibility, economy and practicability and the like.

The invention relates to nucleophilic aromatic substitution reactions done in an aqueous micellar solvent system, wherein the micelles are formed by specific alkoxylated alcohols.

An object is to provide a method for producing a homocoupling reaction product, which can be carried out substantially without the use of organic solvents, allows a reaction to be carried out under mild reaction conditions by a simple reaction operation, allows a wide range of organic halogen compounds to be used as raw materials, can provide a reaction product in a short time in high yield, and can provide a reaction product having a high molecular weight. Provided as a solution is a method for producing a homocoupling reaction product of an organic halogen compound represented by formula (I), the method including subjecting the organic halogen compound represented by formula (I);         A1-Xm     (I) (In formula (I), A1 represents an optionally substituted m-valent aromatic hydrocarbon group, an optionally substituted m-valent aromatic heterocyclic group, an optionally substituted m-valent heterocyclic group, an optionally substituted m-valent aliphatic hydrocarbon group, or an optionally substituted m-valent unsaturated aliphatic hydrocarbon group. X represents chlorine, bromine, or iodine, and when a plurality of X's are present, they may be identical to or different from each other. m is the number of X and represents an integer of 1 or more.) to a reaction in the presence of a nickel catalyst under a condition (a) and / or a condition (b); Condition (a): a condition where the amount of a solvent used is 0.8 mL or less relative to 1 mmol of the organic halogen compound, Condition (b): a condition where a heteroatom-containing compound is present, by a mechanochemical method.

Gold (I) complexes that can absorb light in the near-UV and / or visible regions and methods of making and using thereof are described. These gold (I) complexes have photochemical reactivities, such as strong absorption of near-UV and / or visible light, quenching rate constants ≥3.5×105 s-1, etc., that allow them to catalyze photoredox reations, such as homocoupling of organic halides (e.g. alkyl halides and aryl halides), alkylation of 2-phenyl-1,2,3,4-tetrahydroisoquinoline, cyclization of indoles, reductive dehalogenation of aryl halides, and / or C-H bonds cleavage, under near-UV and / or visible light. The product of a photo-induced organic reaction catalyzed by the gold (I) complexes described herein can have a yield that is higher than the yield of the same product formed from the same reaction under the same reaction conditions, using the same loading or a higher loading of [Au2(µ-dppm)2](Cl)2, [Ru(bpy)3](Cl)2, and / or [fac-Ir(ppy)3] compared to the loading of the one or more gold (I) complex(es).

There are many benefits to organometallic catalysis, especially in homogeneous catalysis for C(sp2)-H bond activation and new C-C bond formation reactions. These catalysts, which are mainly transition metal complexes with organic ligands, are very reactive and selective, which increases the range and effectiveness of different synthetic transformations. Their capacity to activate C-H bonds under mild reaction conditions is a key advantage as it allows for the direct C-H alkylation of aryl ketones without the need for transient functional groups. This reduces utilization of chemicals, cost and energy used in addition to streamlining synthetic routes. Furthermore, complex molecular architectures with high stereo- and regioselectivity may be formed with the help of organometallic homogenous catalysts, making precise synthesis of complex molecules possible. The present catalyst is easy to use, industrially scalable, recyclable, and provides excellent yields of C-H alkylated products from nonactivated alkyl halides. The reported methods need the use of excess (2-6 equivalent) of alkyl halides but this catalyst performs the catalytic reaction in the stoichiometric quantities of aryl ketone and alkyl halides.

The application discloses a method for synthesizing alkenyl borate ester compounds through a series reaction of palladium-catalyzed cross-coupling and iron-catalyzed borohydration, and belongs to the field of organic synthesis. The method inserts multiple methylene units into the carbon-carbon sigma-bond of the alkenyl borate ester through a series reaction of palladium-catalyzed cross-coupling and iron-catalyzed borohydration, and meanwhile, a valuable C(sp 2 )‑B functional group is reserved. The method utilizes the universality of the alkenyl borate ester in the cross-coupling reaction, provides an efficient approach for modular and iterative synthesis of C(sp3) homologues of bioactive molecules containing olefin structures, and is expected to accelerate the drug discovery process, applied to efficient preparation of drug molecule homologues and complex organic compounds, and provides a powerful tool for realizing rapid structural derivatization of drug lead compounds.

This invention provides a method for preparing an intermediate for preparing an NTK inhibitor. [Solution] a) Form a reaction mixture comprising the following compound 170, the following compound 181, a palladium catalyst, and a solvent system containing a base, wherein the equivalent ratio of the palladium catalyst to compound 170 is less than approximately 0.001:1 to 0.005:1, (b) The following scheme: TIFF2026086461000160.tif47170 A method is provided which involves reacting a reaction mixture according to the method to form a reaction product mixture containing compound 190.

The present invention relates to bis-aminophosphines which are useful as catalysts for the dimerization of alkyl acrylates. Furthermore, the present invention relates to a process for preparing bis-aminophophines, the use of these bis-aminophosphines as catalysts for dimerization reaction of alkyl acrylates and a process for obtaining dimers of alkyl acrylates using bis-aminophosphines as catalyst.

The present invention relates to bis-aminophosphines which are useful as catalysts for the dimerization of alkyl acrylates. Furthermore, the present invention relates to a process for preparing bis-aminophophines, the use of these bis-aminophosphines as catalysts for dimerization reaction of alkyl acrylates and a process for obtaining dimers of alkyl acrylates using bis-aminophosphines as catalyst.

Disclosed is a rapid automated iterative cross-coupling platform that utilizes stable boronate building blocks and isolable boronate ester intermediates. Also disclosed are methods for activating boronate reagents.