45results about "Hydrazone preparation" patented technology

The invention discloses an antibacterial bioactive glass composite material for skull defect repair and a preparation method thereof, and relates to the technical field of bioactive glass materials. The antibacterial bioactive glass composite material for skull defect repair is prepared from the following raw materials in parts by weight: 8 to 15 parts of collagen, 45 to 55 parts of bioactive glass, 20 to 30 parts of hydroxyapatite, 5 to 8 parts of a toughening agent, 1 to 2 parts of an antibacterial agent and 150 to 250 parts of deionized water. The antibacterial bioactive glass composite material for skull defect repair prepared by the invention has excellent bending strength and antibacterial property.

The present invention proposes a method and use for stabilizing a simple agglomerate for pH and salt and with adjustable size. In phosphoric acid buffer solutions with different salt concentrations and pH values, the polyacrylic acid hydroxypropyl group condensation body has specific stability; hydrophobic thermal response blocks are introduced into a hydroxypropyl acrylate monomer through reversible addition-fragmentation chain transfer polymerization to regulate and control the size of a condensation body, and a phase separation behavior is shown at different temperatures; a hydrophobic block without thermal response is introduced to regulate and control the size of the aggregate, and no thermal response behavior is shown. Continuous regulation and control of the size of the aggregate from the micron level to the nano level are achieved, and the requirements of different application scenes are met. The hydroxypropyl polyacrylate condensation body can be used for packaging various dyes and drugs; high-efficiency enzyme protection is achieved, formed aggregates can protect glucose oxidase, and the retention rate of enzyme activity reaches 85% or above after treatment is conducted for 3 hours at 60 DEG C; as a micro-reactor for the reaction of generating p-nitrobenzaldehyde phenylhydrazone from p-nitrobenzaldehyde and phenylhydrazine, the reaction rate is greatly improved.

Provided is a polymerizable liquid crystal compound represented by general formula (I). [In general formula (I), J1 represents a monovalent group represented by general formula (J-1), and the symbols in general formula (I) and general formula (J-1) are as defined in the description.]

The invention provides an aldehyde insect pheromone derivative, which takes a compound containing at least one primary amine group as a carrier, and aldehyde insect pheromone forms an imine derivative with the compound through chemical reaction. The invention also provides a preparation method, application and a release method of the aldehyde insect pheromone derivative. According to the aldehyde insect pheromone derivative provided by the invention, aldehyde insect pheromones are treated in a chemical reaction manner, the stability of the aldehyde insect pheromones can be remarkably improved, slow release and controlled release of the pheromones can also be realized, the carrier material is wide in source, more in selectivity, convenient and economical, and in addition, the aldehyde insect pheromone derivative has good application prospects. The aldehyde insect pheromone derivative provided by the invention can also realize combined fixation and release of various pheromones, so that trapping, prevention and control of various insects can be realized.

The invention relates to the field of biomedicine, and discloses a preparation method and application of an I-type composite photosensitizer with hydrogen sulfide detection performance. According to the invention, TPA-CHO and MN are adopted as monomers, a Schiff base reaction is adopted to synthesize a triphenylamine derivative TPAB with an A-pi-D-pi-A conjugated structure, Cu < 2 + > is further introduced into TPAB molecules, and a stable metal complex composite photosensitizer is formed through a coordinate bond. The functional composite photosensitizer TPAB-Cu < 2 + > has the characteristic of mainly generating I-type ROS and has efficient photodynamic bactericidal activity in an anoxic drug-resistant bacterium infection environment, and in addition, the functional molecule can be applied to drug-resistant bacterium infection microenvironment hydrogen sulfide level detection so as to realize early warning of drug-resistant bacterium infection and real-time detection of a treatment process; the technical problems that in an existing photodynamic therapy, the oxygen dependence of a photosensitizer is high, and the response sensitivity and specificity of a drug-resistant bacterium infection microenvironment are insufficient are solved.

This application relates to the biomedical field and discloses a method for preparing a type I composite photosensitizer with both hydrogen sulfide detection capabilities and its uses. The invention synthesizes a triphenylamine derivative TPAB with an A-π-D-π-A conjugated structure using TPA-CHO and MN as monomers via a Schiff base reaction, and further incorporates Cu... 2+ By introducing TPAB molecules, a stable metal complex photosensitizer is formed through coordination bonds. This application presents the functional composite photosensitizer TPAB-Cu. 2+ Characterized primarily by the generation of type I ROS, it exhibits highly efficient photodynamic bactericidal activity in hypoxic environments infected with drug-resistant bacteria. Furthermore, this functional molecule can be used to detect hydrogen sulfide levels in the microenvironment of drug-resistant bacterial infections, enabling early warning and real-time monitoring of the treatment process. This solves the technical problems of strong oxygen dependence of photosensitizers and insufficient sensitivity and specificity in response to the microenvironment of drug-resistant bacterial infections in existing photodynamic therapies.

A method for preparing the insecticide N-(1-methylcyclopropyl)-2-(3-pyridinyl)-2H-indazole 4-carboxamide is disclosed. A method for preparing the intermediate N-(1-methylcyclopropyl)-2-(3-pyridinyl)-2H-indazole 4-carboxamide is also disclosed.

The invention relates to the technical field of biurea preparation, in particular to a system and a method for continuously preparing biurea. According to the method, acetone, liquid ammonia, chlorine and urea are used as raw materials, a continuous flow reactor with a micro-channel reactor and a tubular reactor is used, biurea is generated by adopting an acetone azine process route, and the byproduct acetone and ammonia are directly recycled after being condensed and absorbed, so that the consumption cost of the raw materials is greatly reduced, the resource utilization rate is increased, and the method has outstanding economic benefits. According to the method, the high-risk ketazine synthesis reaction is limited in a channel with extremely small liquid holdup to be safely carried out at low temperature, the explosion risk caused by accumulation of nitrogen-containing intermediates is greatly reduced, inorganic acid and alkali metal salt are not introduced into the whole process, the process is green and environment-friendly, high-salinity wastewater is completely eradicated from the reaction principle, the most important pollution source is eliminated from the source, and the production cost is reduced. And the environmental protection advantage is extremely remarkable, and the most severe environmental protection difficulty of the traditional process is solved. And the process is green, environment-friendly, low in energy consumption and suitable for large-scale and automatic production.

The application belongs to the technical field of organic synthesis, and particularly relates to a method for efficiently and greenly preparing allyl ketoxime in one step. The preparation method specifically comprises the following steps: cross-coupling reaction of enol, hydrazine and aldehyde under the action of a palladium catalyst to obtain an allyl ketoxime compound. The reaction raw materials used in the application are cheap and easy to obtain. The allyl ketoxime compound can be efficiently and greenly prepared in one step through the coupling reaction, the synthesis process is simple, and the synthesis cost is greatly reduced. The reaction condition is mild, the yield is high, the substrate applicability range is wide, the reaction conversion efficiency is high, the gram-scale experiment can be realized, and industrialization is easy to realize.

The application discloses a kind of photo-curing mussel biomimetic acylhydrazone and its preparation method and application, the structural formula of the photo-curing mussel biomimetic acylhydrazone is as shown in formula (I).The photo-curing mussel biomimetic acylhydrazone of the application has catechol structure and carbon-carbon double bond, raw material is low in price, synthesis process does not need to modify catechol structure, preparation method is simple, can reduce the synthesis difficulty and production cost of mussel biomimetic material.The mussel biomimetic photo-curing adhesive composition prepared by using photo-curing mussel biomimetic acylhydrazone as raw material has good adhesive property, and can improve the problem of insufficient adhesion and failure of photo-curing adhesive, and prevent falling.

The invention relates to acylhydrazone molecules capable of activating solid-state fluorescence or photochromism and preparation and application thereof, in the molecular structure, by changing a substituent R on a-N (R)-group on one side of benzoyl hydrazine, the conformation and accumulation mode of the molecules can be adjusted, so that selective activation of the fluorescence or photochromism property of the acylhydrazone molecules in a solid state is realized. When the substituent R is-H, the molecular conformation is planar, and the intermolecular accumulation is tight. In a solid state, the compound shows an excitation wavelength dependent fluorescence property, and when the wavelength of excitation light is changed, the fluorescence color is switched between blue and green. When the substituent R is-CH3, due to the steric effect of-CH3, the molecular conformation is distorted, and the accumulation among molecules becomes more loose. When ultraviolet light and visible light are alternately used for irradiation in a short time, the color of the powder can be rapidly switched between white and orange. The method provided by the invention is not influenced by R'on a benzene ring, and shows good universality.

Processes for preparing (((3aR,6aS)-5-(4,6-dimethylpyrimidin-2-yl)hexahydropyrrolo[3,4-c]pyrrol-2(1H)-yl)(2-fluoro-6-(2H-1,2,3-triazol-2-yl)phenyl)methanoneare described, which are useful for commercial manufacturing. Said compound is an orexin receptor modulator and may be useful in pharmaceutical compositions and methods for the treatment of diseased states, disorders, and conditions mediated by orexin activity, such as insomnia and depression.

The invention provides a preparation method of hydrazine hydrate, which comprises the following steps: in the presence of a catalyst and under reaction conditions, introducing methyl ethyl ketazine and water into a reaction section of a composite rectifying tower for contact reaction, and then continuously producing a hydrazine hydrate solution from a tower kettle. The preparation method of hydrazine hydrate provided by the invention can catalytically hydrolyze methyl ethyl ketazine under low-temperature and low-pressure reaction conditions, and meanwhile, the concentration and yield of hydrazine hydrate are improved.

The invention discloses a fully continuous flow chemical synthesis method of an apixaban intermediate (Z)-2-chloro [(4-methoxyphenyl) hydrazono] ethyl acetate. The fully continuous flow chemical synthesis method comprises the following steps: introducing a sodium nitrite solution, a solution of a compound as shown in a formula (I) and acid into a dynamic tubular reactor, and carrying out diazotization reaction under the condition that the temperature is not higher than 0 DEG C; and introducing a sodium acetate solution and an ethyl 2-chloroacetoacetate solution into the microchannel reactor, mixing with the diazotization reaction solution, carrying out a Jappp-Klingemann reaction at-5-2 DEG C, and concentrating to obtain the apixaban intermediate compound shown in the formula (II). The invention provides a full-continuous flow chemical synthesis method of an apixaban intermediate (Z)-2-chloro [(4-methoxyphenyl) hydrazono] ethyl acetate. The target product can be efficiently prepared in dozens of seconds in a high-purity and high-yield manner.

The invention relates to the technical field of chemical synthesis, in particular to a recovery method and application of a methyl ethyl ketazine working solution, the methyl ethyl ketazine working solution comprises an amide catalyst, an acid ammonium catalyst and water, and the recovery method of the methyl ethyl ketazine working solution comprises two steps: S1, concentration of a methyl ethyl ketazine synthesis reaction solution; s2, the methyl ethyl ketazine working solution is recycled, the target product methyl ethyl ketazine and the recycled methyl ethyl ketazine reaction solution are finally obtained, the tubular reactor is utilized in the methyl ethyl ketazine working solution recycling process, rapid and efficient recycling of the methyl ethyl ketazine working solution is achieved, and compared with an existing methyl ethyl ketazine working solution recycling mode, the reaction efficiency is remarkably improved, and the production cost is reduced. The treatment time is greatly shortened, the method is easier to realize industrial amplification and production, and an innovative and practical technical scheme is provided for efficient synthesis of methyl ethyl ketazine and recovery of the catalyst.

This application provides a positive electrode additive and its preparation method, a positive electrode sheet, a secondary battery, and a battery pack, wherein the positive electrode additive includes a fluorohydrazone compound represented by Formula I or Formula II. In Formula I, R1, R2, and R3 are each independently selected from -H or -F, and R1, R2, and R3 are not simultaneously -H; R4 is selected from substituted or unsubstituted alkyl, halogen, or nitro groups. In Formula II, R5, R6, and R7 are each independently selected from -H or -F, and R5, R6, and R7 are not simultaneously -H; R8 is selected from substituted or unsubstituted alkyl, halogen, or nitro groups.

The application provides an EGFR / HER2 inhibitor based on a hydrazone structure, a preparation method and application thereof, and belongs to the field of medicines; specifically provides a hydrazone derivative, which has a chemical structural formula as shown in formula A, wherein R is a methyl group or a hydrogen group, and X is halogen, a hydroxyl group or a methoxyl group; and a preparation method of the hydrazone derivative is provided; the hydrazone derivative provided by the application has an antitumor effect as an EGFR and / or HER2 inhibitor, and can be used for preparing an antitumor drug. Formula A

The present invention relates to sesquiterpenoid laurene derivatives I-1 to I-14, their preparation methods, and their use in preventing and treating plant viral pathogens and fungi. The present invention develops an efficient synthesis method for sesquiterpenoid laurene derivatives, laying a foundation for the synthesis and biological activity research of such sesquiterpenes. The sesquiterpenoid derivatives I-1 to I-14 of the present invention have anti-plant viral activity and can inhibit tobacco mosaic virus. Furthermore, the compounds exhibit broad-spectrum anti-plant pathogen activity.

The present invention provides an aldehyde-based insect pheromone derivative. A compound containing at least one primary amine group is used as a carrier, and an aldehyde-based insect pheromone forms an imine derivative with the carrier by means of a chemical reaction. The present invention further provides a preparation method and use of the aldehyde-based insect pheromone derivative, and a release method. By means of the treatment of the aldehyde-based insect pheromone in a chemical reaction, the aldehyde-based insect pheromone derivative provided by the present invention can exhibit significantly improved stability and can also realize the sustained release and controlled release of the pheromone. The carrier material has a wide range of sources, diverse choices, convenience, and economy. In addition, the aldehyde-based insect pheromone derivative provided by the present invention can also realize the combined fixation and release of multiple pheromones, thereby enabling the trapping, prevention and control of multiple insects.

The application belongs to the technical field of biological medicine, and particularly relates to a substituted phenoxy acetic hydrazine compound, a preparation method thereof and application of the compound as an anti-inflammatory inhibitor of STAT3. The compound has a structure as shown in formula I. It is verified through experiments that the compound is an allosteric small-molecule compound combined with a STAT3 CCD structure domain, has high affinity, high membrane permeability and high selectivity. In a cell and a mouse acute lung injury model, the inhibitor is used to inhibit an inflammatory response of acute lung injury, so as to achieve the effect of relieving acute lung injury. The application provides a theoretical basis for drug treatment of development of a new STAT3 allosteric inhibitor for relieving an inflammatory response of acute lung injury.

The invention relates to a method for preparing 4-(4-methoxyphenyl)-1-butanol through selective reduction, which comprises the following steps of: a, reacting 4-(4-methoxyphenyl)-2-oxobutyric acid serving as a raw material with hydrazine hydrate at low temperature under the acidic condition that the pH value is equal to 3-5 to form a hydrazone intermediate; b, adding alkali metal hydroxide and Zn powder into the hydrazone intermediate, and carrying out high-temperature reduction dehydration reaction; and c, carrying out a quenching reaction under an acidic condition, and separating a target product to obtain a target compound, namely 4-(4-methoxyphenyl)-1-butanol. According to the method for preparing 4-(4-methoxyphenyl)-1-butanol through selective reduction, beta-keto acid is efficiently and selectively reduced into alcohol through a hydrazine hydrate gradient reduction system under the carboxyl coexistence condition, and the problem of excessive reduction or decarboxylation caused by carboxyl interference in a traditional process is solved.

The invention discloses a fluorescent probe for detecting trace water in an organic solvent and its preparation and application, including: adding 3-hydroxy-2-naphthoic acid hydrazine and anhydrous ethanol to a reaction vessel, stirring and dissolving; then adding 2-hydroxy-5-tert-butylbenzaldehyde, gradually heating, dripping glacial acetic acid when anhydrous ethanol starts to reflux, then heating to reflux under nitrogen protection, and monitoring the reaction progress using thin layer chromatography; after the reaction is complete, naturally cool to room temperature, filter under normal pressure to obtain a crude product, wash with hot anhydrous ethanol multiple times, each for half an hour, and finally filter and dry to obtain a white solid powder, i.e., a fluorescent probe for detecting trace water in an organic solvent. Based on the experimental results of the present invention, it can be proved that the fluorescent probe for detecting water in tetrahydrofuran, dimethyl sulfoxide and acetone is a new type of highly sensitive fluorescent sensing molecule; it can achieve the purpose of detecting trace water in an organic solvent.

The present invention relates to the synthesis of 3-[(1S,2S)-1-[5-[(4S)-2,2-dimethyloxan-4-yl]-2-[(4S)-2-(4-fluoro-3,5-dimethylphenyl)-3-[3-(4-fluoro-1-methylindazol-5-yl)-2-oxoimidazol-1-yl]-4-methyl-6,7-dihydro-4H-pyrazolo[4,3-c]pyridine-5-carbonyl]indol-1-yl]-2-methylcyclopropyl]-4H-1,2,4-oxadiazol-5-one or a salt thereof, and related synthetic intermediate compounds.

The application discloses a small-molecule gelling agent containing a hydrazone group, a synthesis method of the small-molecule gelling agent and application of the small-molecule gelling agent in preparation of borneol assembly. The small-molecule gelling agent is prepared through Williamson etherification reaction of a hydroxybenzaldehyde compound and a bromoalkane and then condensation reaction with a hydrazine compound, and the structure of the small-molecule gelling agent contains functional groups such as a hydrazone group, an alkyl chain and a phenolic hydroxyl group, and the small-molecule gelling agent can self-assemble into a three-dimensional network gel structure through non-covalent interactions such as hydrogen bonds and pi-pi stacking. The gelling agent can be used for clathration of volatile drugs borneol, and preparation of borneol-small-molecule gelling agent xerogel, thereby significantly reducing the volatile loss of borneol, and improving the thermal stability, light stability and wet stability of the borneol. The assembly has lower toxicity than free borneol. When the assembly is applied to compound Danshen tablets, the pharmaceutical stability of borneol can be effectively improved, and the anti-myocardial ischemia efficacy of the preparation can be ensured. The application provides a novel, efficient and low-toxicity solution for the stabilization of volatile traditional Chinese medicine components.

The application discloses a chemical synthesis method of nitrogen-hydroxyl triazene derivatives, relates to the technical field of chemical synthesis, and specifically discloses the following steps: reacting a halogenated benzyl reagent or an aromatic formaldehyde reagent with hydrazine hydrate to generate an intermediate 1; reacting the intermediate 1 with a nitrosating reagent to generate an intermediate 2; condensing the intermediate 2 with an aldehyde compound to generate an intermediate 3; and deprotecting the intermediate 3 by using a dearylbzyl reagent to obtain a target product. The application optimizes a reaction path and a purification process, solves the problems of low yield and complex purification in the prior art, is especially suitable for efficient preparation of triazene C, and has the advantages of mild conditions, low cost and the like, and provides a feasible scheme for large-scale production of nitrogen-hydroxyl triazene derivatives.

The present application relates to a kind of one-step efficient preparation allyl acyl hydrazone method, specifically, using simple allyl alcohol, hydrazine and aldehyde as raw material, cross coupling reaction occurs under the action of CO and palladium catalyst, obtain allyl acyl hydrazone compound, belong to organic synthesis technical field.The reaction raw material used in the present application is cheap and easy to obtain, by coupling reaction, allyl acyl hydrazone compound can be efficiently prepared in one step;The reaction raw material and catalyst and ligand are cheap and easy to obtain, and the synthesis process is simple, which greatly reduces the synthesis cost;Reaction process is high in atomic economy, reaction product yield is excellent, and has excellent regioselectivity;Reaction conversion efficiency is higher, can realize gram-scale experiment, easy to realize industrialization.

The invention relates a processes for preparing a compound of Formula I or a pharmaceutically acceptable salt thereof, which are useful for the treatment of cardiovascular disease, endothelial dysfunction, diastolic dysfunction, atherosclerosis, hypertension, heart failure, pulmonary hypertension (WHO groups I, II, III, IV), angina pectoris, thrombosis, restenosis, myocardial infarction, stroke, cardiac insufficiency, fibrosis, pulmonary hypertonia, erectile dysfunction, asthma, chronic kidney disease, diabetes, cirrhosis of the liver, chronic obstructive pulmonary disease (COPD), acute respiratory distress syndrome, acute lung injury, pulmonary fibrosis, cystic fibrosis, or interstitial lung disease. The invention also relates to intermediates used in the processes for preparing the compound of Formula I.

The invention discloses a process and a device for preparing carbidopa through continuous flow reaction, and the process comprises the following steps: firstly mixing cyclohexanone and a solvent, then reacting with ammonia water and sodium hypochlorite to generate 1-oxa-2-azaspiro [2.5] octane, and carrying out gas-liquid-liquid phase separation to obtain an organic phase and 2-amino-3-(3, 3, 5, 6-tetramethyl-2-oxo-2-azaspiro [2.5] octane; the preparation method comprises the following steps: reacting 2-[(cyclohexyl) hydrazino]-3-(3, 4-dihydroxyphenyl)-2-methyl propionate (methyl dopa methyl ester) to generate 2-[(cyclohexyl) hydrazino]-3-(3, 4-dihydroxyphenyl)-2-methyl propionate, and finally hydrolyzing with hydrochloric acid to obtain carbidopa. According to the invention, the synthesis of high-purity and high-content carbidopa is realized through the full-flow continuous flow reactor. The yield reaches 90%, and the purity reaches 99% or above. The reaction system solves the problems that the reaction temperature is difficult to control, the production efficiency is low, an intermediate product is unstable and the like in an existing kettle type process, the yield and the purity of a target product are remarkably improved, material consumption is greatly reduced, and the reaction system has the advantages of being short in production period, high in selectivity, continuous in production and intrinsically safe.

This invention belongs to the field of medicinal chemistry and relates to ferulate hydrazide compounds and their uses. Specifically, this invention provides compounds of formula I or pharmaceutically acceptable salts, stereoisomers, tautomers, polymorphs, solvates, racemates, prodrugs, or metabolites thereof, which exhibit good antitumor activity.