33results about "Hydrazone preparation" patented technology

The invention discloses an antibacterial bioactive glass composite material for skull defect repair and a preparation method thereof, and relates to the technical field of bioactive glass materials. The antibacterial bioactive glass composite material for skull defect repair is prepared from the following raw materials in parts by weight: 8 to 15 parts of collagen, 45 to 55 parts of bioactive glass, 20 to 30 parts of hydroxyapatite, 5 to 8 parts of a toughening agent, 1 to 2 parts of an antibacterial agent and 150 to 250 parts of deionized water. The antibacterial bioactive glass composite material for skull defect repair prepared by the invention has excellent bending strength and antibacterial property.

The present invention proposes a method and use for stabilizing a simple agglomerate for pH and salt and with adjustable size. In phosphoric acid buffer solutions with different salt concentrations and pH values, the polyacrylic acid hydroxypropyl group condensation body has specific stability; hydrophobic thermal response blocks are introduced into a hydroxypropyl acrylate monomer through reversible addition-fragmentation chain transfer polymerization to regulate and control the size of a condensation body, and a phase separation behavior is shown at different temperatures; a hydrophobic block without thermal response is introduced to regulate and control the size of the aggregate, and no thermal response behavior is shown. Continuous regulation and control of the size of the aggregate from the micron level to the nano level are achieved, and the requirements of different application scenes are met. The hydroxypropyl polyacrylate condensation body can be used for packaging various dyes and drugs; high-efficiency enzyme protection is achieved, formed aggregates can protect glucose oxidase, and the retention rate of enzyme activity reaches 85% or above after treatment is conducted for 3 hours at 60 DEG C; as a micro-reactor for the reaction of generating p-nitrobenzaldehyde phenylhydrazone from p-nitrobenzaldehyde and phenylhydrazine, the reaction rate is greatly improved.

Provided is a polymerizable liquid crystal compound represented by general formula (I). [In general formula (I), J1 represents a monovalent group represented by general formula (J-1), and the symbols in general formula (I) and general formula (J-1) are as defined in the description.]

The invention provides an aldehyde insect pheromone derivative, which takes a compound containing at least one primary amine group as a carrier, and aldehyde insect pheromone forms an imine derivative with the compound through chemical reaction. The invention also provides a preparation method, application and a release method of the aldehyde insect pheromone derivative. According to the aldehyde insect pheromone derivative provided by the invention, aldehyde insect pheromones are treated in a chemical reaction manner, the stability of the aldehyde insect pheromones can be remarkably improved, slow release and controlled release of the pheromones can also be realized, the carrier material is wide in source, more in selectivity, convenient and economical, and in addition, the aldehyde insect pheromone derivative has good application prospects. The aldehyde insect pheromone derivative provided by the invention can also realize combined fixation and release of various pheromones, so that trapping, prevention and control of various insects can be realized.

The invention relates to the field of biomedicine, and discloses a preparation method and application of an I-type composite photosensitizer with hydrogen sulfide detection performance. According to the invention, TPA-CHO and MN are adopted as monomers, a Schiff base reaction is adopted to synthesize a triphenylamine derivative TPAB with an A-pi-D-pi-A conjugated structure, Cu < 2 + > is further introduced into TPAB molecules, and a stable metal complex composite photosensitizer is formed through a coordinate bond. The functional composite photosensitizer TPAB-Cu < 2 + > has the characteristic of mainly generating I-type ROS and has efficient photodynamic bactericidal activity in an anoxic drug-resistant bacterium infection environment, and in addition, the functional molecule can be applied to drug-resistant bacterium infection microenvironment hydrogen sulfide level detection so as to realize early warning of drug-resistant bacterium infection and real-time detection of a treatment process; the technical problems that in an existing photodynamic therapy, the oxygen dependence of a photosensitizer is high, and the response sensitivity and specificity of a drug-resistant bacterium infection microenvironment are insufficient are solved.

This application relates to the biomedical field and discloses a method for preparing a type I composite photosensitizer with both hydrogen sulfide detection capabilities and its uses. The invention synthesizes a triphenylamine derivative TPAB with an A-π-D-π-A conjugated structure using TPA-CHO and MN as monomers via a Schiff base reaction, and further incorporates Cu... 2+ By introducing TPAB molecules, a stable metal complex photosensitizer is formed through coordination bonds. This application presents the functional composite photosensitizer TPAB-Cu. 2+ Characterized primarily by the generation of type I ROS, it exhibits highly efficient photodynamic bactericidal activity in hypoxic environments infected with drug-resistant bacteria. Furthermore, this functional molecule can be used to detect hydrogen sulfide levels in the microenvironment of drug-resistant bacterial infections, enabling early warning and real-time monitoring of the treatment process. This solves the technical problems of strong oxygen dependence of photosensitizers and insufficient sensitivity and specificity in response to the microenvironment of drug-resistant bacterial infections in existing photodynamic therapies.

A method for preparing the insecticide N-(1-methylcyclopropyl)-2-(3-pyridinyl)-2H-indazole 4-carboxamide is disclosed. A method for preparing the intermediate N-(1-methylcyclopropyl)-2-(3-pyridinyl)-2H-indazole 4-carboxamide is also disclosed.

The invention relates to the technical field of biurea preparation, in particular to a system and a method for continuously preparing biurea. According to the method, acetone, liquid ammonia, chlorine and urea are used as raw materials, a continuous flow reactor with a micro-channel reactor and a tubular reactor is used, biurea is generated by adopting an acetone azine process route, and the byproduct acetone and ammonia are directly recycled after being condensed and absorbed, so that the consumption cost of the raw materials is greatly reduced, the resource utilization rate is increased, and the method has outstanding economic benefits. According to the method, the high-risk ketazine synthesis reaction is limited in a channel with extremely small liquid holdup to be safely carried out at low temperature, the explosion risk caused by accumulation of nitrogen-containing intermediates is greatly reduced, inorganic acid and alkali metal salt are not introduced into the whole process, the process is green and environment-friendly, high-salinity wastewater is completely eradicated from the reaction principle, the most important pollution source is eliminated from the source, and the production cost is reduced. And the environmental protection advantage is extremely remarkable, and the most severe environmental protection difficulty of the traditional process is solved. And the process is green, environment-friendly, low in energy consumption and suitable for large-scale and automatic production.

The application belongs to the technical field of organic synthesis, and particularly relates to a method for efficiently and greenly preparing allyl ketoxime in one step. The preparation method specifically comprises the following steps: cross-coupling reaction of enol, hydrazine and aldehyde under the action of a palladium catalyst to obtain an allyl ketoxime compound. The reaction raw materials used in the application are cheap and easy to obtain. The allyl ketoxime compound can be efficiently and greenly prepared in one step through the coupling reaction, the synthesis process is simple, and the synthesis cost is greatly reduced. The reaction condition is mild, the yield is high, the substrate applicability range is wide, the reaction conversion efficiency is high, the gram-scale experiment can be realized, and industrialization is easy to realize.

The invention relates to acylhydrazone molecules capable of activating solid-state fluorescence or photochromism and preparation and application thereof, in the molecular structure, by changing a substituent R on a-N (R)-group on one side of benzoyl hydrazine, the conformation and accumulation mode of the molecules can be adjusted, so that selective activation of the fluorescence or photochromism property of the acylhydrazone molecules in a solid state is realized. When the substituent R is-H, the molecular conformation is planar, and the intermolecular accumulation is tight. In a solid state, the compound shows an excitation wavelength dependent fluorescence property, and when the wavelength of excitation light is changed, the fluorescence color is switched between blue and green. When the substituent R is-CH3, due to the steric effect of-CH3, the molecular conformation is distorted, and the accumulation among molecules becomes more loose. When ultraviolet light and visible light are alternately used for irradiation in a short time, the color of the powder can be rapidly switched between white and orange. The method provided by the invention is not influenced by R'on a benzene ring, and shows good universality.

Processes for preparing (((3aR,6aS)-5-(4,6-dimethylpyrimidin-2-yl)hexahydropyrrolo[3,4-c]pyrrol-2(1H)-yl)(2-fluoro-6-(2H-1,2,3-triazol-2-yl)phenyl)methanoneare described, which are useful for commercial manufacturing. Said compound is an orexin receptor modulator and may be useful in pharmaceutical compositions and methods for the treatment of diseased states, disorders, and conditions mediated by orexin activity, such as insomnia and depression.

The invention discloses a fully continuous flow chemical synthesis method of an apixaban intermediate (Z)-2-chloro [(4-methoxyphenyl) hydrazono] ethyl acetate. The fully continuous flow chemical synthesis method comprises the following steps: introducing a sodium nitrite solution, a solution of a compound as shown in a formula (I) and acid into a dynamic tubular reactor, and carrying out diazotization reaction under the condition that the temperature is not higher than 0 DEG C; and introducing a sodium acetate solution and an ethyl 2-chloroacetoacetate solution into the microchannel reactor, mixing with the diazotization reaction solution, carrying out a Jappp-Klingemann reaction at-5-2 DEG C, and concentrating to obtain the apixaban intermediate compound shown in the formula (II). The invention provides a full-continuous flow chemical synthesis method of an apixaban intermediate (Z)-2-chloro [(4-methoxyphenyl) hydrazono] ethyl acetate. The target product can be efficiently prepared in dozens of seconds in a high-purity and high-yield manner.

This application provides a positive electrode additive and its preparation method, a positive electrode sheet, a secondary battery, and a battery pack, wherein the positive electrode additive includes a fluorohydrazone compound represented by Formula I or Formula II. In Formula I, R1, R2, and R3 are each independently selected from -H or -F, and R1, R2, and R3 are not simultaneously -H; R4 is selected from substituted or unsubstituted alkyl, halogen, or nitro groups. In Formula II, R5, R6, and R7 are each independently selected from -H or -F, and R5, R6, and R7 are not simultaneously -H; R8 is selected from substituted or unsubstituted alkyl, halogen, or nitro groups.

The application provides an EGFR / HER2 inhibitor based on a hydrazone structure, a preparation method and application thereof, and belongs to the field of medicines; specifically provides a hydrazone derivative, which has a chemical structural formula as shown in formula A, wherein R is a methyl group or a hydrogen group, and X is halogen, a hydroxyl group or a methoxyl group; and a preparation method of the hydrazone derivative is provided; the hydrazone derivative provided by the application has an antitumor effect as an EGFR and / or HER2 inhibitor, and can be used for preparing an antitumor drug. Formula A

The present invention provides an aldehyde-based insect pheromone derivative. A compound containing at least one primary amine group is used as a carrier, and an aldehyde-based insect pheromone forms an imine derivative with the carrier by means of a chemical reaction. The present invention further provides a preparation method and use of the aldehyde-based insect pheromone derivative, and a release method. By means of the treatment of the aldehyde-based insect pheromone in a chemical reaction, the aldehyde-based insect pheromone derivative provided by the present invention can exhibit significantly improved stability and can also realize the sustained release and controlled release of the pheromone. The carrier material has a wide range of sources, diverse choices, convenience, and economy. In addition, the aldehyde-based insect pheromone derivative provided by the present invention can also realize the combined fixation and release of multiple pheromones, thereby enabling the trapping, prevention and control of multiple insects.

The application belongs to the technical field of biological medicine, and particularly relates to a substituted phenoxy acetic hydrazine compound, a preparation method thereof and application of the compound as an anti-inflammatory inhibitor of STAT3. The compound has a structure as shown in formula I. It is verified through experiments that the compound is an allosteric small-molecule compound combined with a STAT3 CCD structure domain, has high affinity, high membrane permeability and high selectivity. In a cell and a mouse acute lung injury model, the inhibitor is used to inhibit an inflammatory response of acute lung injury, so as to achieve the effect of relieving acute lung injury. The application provides a theoretical basis for drug treatment of development of a new STAT3 allosteric inhibitor for relieving an inflammatory response of acute lung injury.

The application discloses a small-molecule gelling agent containing a hydrazone group, a synthesis method of the small-molecule gelling agent and application of the small-molecule gelling agent in preparation of borneol assembly. The small-molecule gelling agent is prepared through Williamson etherification reaction of a hydroxybenzaldehyde compound and a bromoalkane and then condensation reaction with a hydrazine compound, and the structure of the small-molecule gelling agent contains functional groups such as a hydrazone group, an alkyl chain and a phenolic hydroxyl group, and the small-molecule gelling agent can self-assemble into a three-dimensional network gel structure through non-covalent interactions such as hydrogen bonds and pi-pi stacking. The gelling agent can be used for clathration of volatile drugs borneol, and preparation of borneol-small-molecule gelling agent xerogel, thereby significantly reducing the volatile loss of borneol, and improving the thermal stability, light stability and wet stability of the borneol. The assembly has lower toxicity than free borneol. When the assembly is applied to compound Danshen tablets, the pharmaceutical stability of borneol can be effectively improved, and the anti-myocardial ischemia efficacy of the preparation can be ensured. The application provides a novel, efficient and low-toxicity solution for the stabilization of volatile traditional Chinese medicine components.

The present application relates to a kind of one-step efficient preparation allyl acyl hydrazone method, specifically, using simple allyl alcohol, hydrazine and aldehyde as raw material, cross coupling reaction occurs under the action of CO and palladium catalyst, obtain allyl acyl hydrazone compound, belong to organic synthesis technical field.The reaction raw material used in the present application is cheap and easy to obtain, by coupling reaction, allyl acyl hydrazone compound can be efficiently prepared in one step;The reaction raw material and catalyst and ligand are cheap and easy to obtain, and the synthesis process is simple, which greatly reduces the synthesis cost;Reaction process is high in atomic economy, reaction product yield is excellent, and has excellent regioselectivity;Reaction conversion efficiency is higher, can realize gram-scale experiment, easy to realize industrialization.

The invention relates a processes for preparing a compound of Formula I or a pharmaceutically acceptable salt thereof, which are useful for the treatment of cardiovascular disease, endothelial dysfunction, diastolic dysfunction, atherosclerosis, hypertension, heart failure, pulmonary hypertension (WHO groups I, II, III, IV), angina pectoris, thrombosis, restenosis, myocardial infarction, stroke, cardiac insufficiency, fibrosis, pulmonary hypertonia, erectile dysfunction, asthma, chronic kidney disease, diabetes, cirrhosis of the liver, chronic obstructive pulmonary disease (COPD), acute respiratory distress syndrome, acute lung injury, pulmonary fibrosis, cystic fibrosis, or interstitial lung disease. The invention also relates to intermediates used in the processes for preparing the compound of Formula I.

The invention discloses a process and a device for preparing carbidopa through continuous flow reaction, and the process comprises the following steps: firstly mixing cyclohexanone and a solvent, then reacting with ammonia water and sodium hypochlorite to generate 1-oxa-2-azaspiro [2.5] octane, and carrying out gas-liquid-liquid phase separation to obtain an organic phase and 2-amino-3-(3, 3, 5, 6-tetramethyl-2-oxo-2-azaspiro [2.5] octane; the preparation method comprises the following steps: reacting 2-[(cyclohexyl) hydrazino]-3-(3, 4-dihydroxyphenyl)-2-methyl propionate (methyl dopa methyl ester) to generate 2-[(cyclohexyl) hydrazino]-3-(3, 4-dihydroxyphenyl)-2-methyl propionate, and finally hydrolyzing with hydrochloric acid to obtain carbidopa. According to the invention, the synthesis of high-purity and high-content carbidopa is realized through the full-flow continuous flow reactor. The yield reaches 90%, and the purity reaches 99% or above. The reaction system solves the problems that the reaction temperature is difficult to control, the production efficiency is low, an intermediate product is unstable and the like in an existing kettle type process, the yield and the purity of a target product are remarkably improved, material consumption is greatly reduced, and the reaction system has the advantages of being short in production period, high in selectivity, continuous in production and intrinsically safe.

This invention belongs to the field of medicinal chemistry and relates to ferulate hydrazide compounds and their uses. Specifically, this invention provides compounds of formula I or pharmaceutically acceptable salts, stereoisomers, tautomers, polymorphs, solvates, racemates, prodrugs, or metabolites thereof, which exhibit good antitumor activity.

The invention provides an aldehyde hydrazone light cage compound which can absorb near ultraviolet light to visible light, and can be subjected to light degradation in a specific wavelength range to release corresponding aldehyde and phenyl compounds. The structure of the aldehyde hydrazone compound can be used as a universal strategy for designing a light release prodrug with high space-time controllability; the material can be degraded by receiving light in vivo and in vitro; and the medicine can also be used as an auxiliary medicine for photodynamic therapy.

The application provides a naringin derivative, a preparation method of the naringin derivative, and application of the naringin derivative in preparation of medicines for preventing and treating wheat scab, tobacco black stem disease, phomopsis stem rot and pepper wilt, and has good bacteriostatic activity on wheat scab fungus, tobacco black stem fungus, phomopsis stem rot fungus and pepper wilt fungus, has a good prevention and treatment effect on plant pathogenic fungal diseases such as wheat scab, tobacco black stem disease, phomopsis stem rot and pepper wilt, and has a broad application prospect and development potential.

The invention relates to an application of an aromatic acylhydrazone compound or a pharmaceutically acceptable salt thereof in preparation of a medicine for treating rheumatoid arthritis, and an application of the aromatic acylhydrazone compound and methotrexate in preparation of the medicine for treating rheumatoid arthritis. When the aromatic acylhydrazone compound is injected into an articular cavity, the arthritis index score of AA rats can be remarkably reduced, joint symptoms are effectively improved, synovial hyperplasia and cartilage injury are relieved, and TNF-alpha induced RA-FLSs abnormal activation can be remarkably inhibited. Meanwhile, the aromatic acylhydrazone compound disclosed by the invention is combined with methotrexate for use, so that the aromatic acylhydrazone compound has a better effect of treating rheumatoid arthritis and has relatively high clinical application value and development prospect.

The invention provides a method for catalytically synthesizing ketazine by using fluorine-containing amide, which comprises the following steps: preheating ketone, fluorine-containing amide, fluorine-containing ammonium acid and a stabilizer EDTA (Ethylene Diamine Tetraacetic Acid) disodium to the reaction temperature of 20-80 DEG C, dropwise adding ammonia water and hydrogen peroxide within 1 hour, and continuously reacting for 0-3 hours to generate ketazine. The method is characterized in that the fluorine-containing amide catalyst is adopted and is different from formamide, acetamide and other amide catalysts, fluorine-containing amide is an amide catalyst difficult to hydrolyze, and the procedure of dehydrating and recycling the catalyst is reduced, so that the energy consumption is greatly reduced, the yield of ketazine is increased, and the yield of ketazine is increased. And the reaction temperature is reduced, so that the generation of an intermediate ketoxime can be reduced.

This invention relates to Zn 2+ This invention relates to the field of concentration detection technology, specifically to an asymmetric enhanced acylhydrazone Schiff base fluorescent probe, its preparation method, and its applications. The fluorescent probe should introduce as many electron-rich atoms as possible, such as O and N, that are favorable to the -C=N- structure space of the Schiff base, thereby creating a more favorable electron-rich chemical environment for coordination between the Schiff base and metal ions. The acylhydrazone Schiff base structure contains three conjugated groups: carbonyl, subamino, and imino. The subamino group contains a lone pair of electrons, which can form p-π conjugations with -C=N- and carbonyl groups, respectively. This conjugated structure makes the Schiff base more stable and less prone to reversible hydrolysis like other Schiff bases. The introduction of the acylhydrazone group enhances the fluorescence of the probe and improves its targeting of Zn. 2+ It exhibits good selectivity, excellent linearity, high sensitivity, low detection limit, and low cost, making it widely applicable to Zn. 2+ The detection of Zn in existing technologies solves the problem. 2+ Fluorescent probe synthesis is complex and costly, and has limitations for Zn. 2+ The problem of low recognition rate.

The application discloses a kind of super-sensitive aluminum ion detection fluorescent probe preparation and application, it is related to converter station valve internal cooling water system aluminum ion fluorescent probe technical field.Probe structure formula is: preparation method is: 4-amino benzhydrazide and 2-hydroxy-1-naphthaldehyde are dissolved in anhydrous ethanol, then reflux, product solution is filtered under vacuum to obtain filtrate, and under the condition of reduced pressure, rotary evaporation dry solvent, obtain benzhydrazide compound based on Schiff base functional group.The application of probe is used to detect the concentration of aluminum ion in sample.The aluminum ion fluorescent probe of the application can be reacted with aluminum ion, and the change of fluorescence spectrum is generated, so that the quantitative detection of aluminum ion is realized.The probe of the application is very sensitive to aluminum ion reaction, so as to facilitate the rapid detection of aluminum ion.The stability of fluorescent probe is good, and then it can be stored for a long time.

The application discloses a kind of full continuous flow chemical synthesis methods of apixaban intermediate (Z)-2-chloro [(4-methoxyphenyl) hydrazono] ethyl acetate.The full continuous flow chemical synthesis method includes the following steps: sodium nitrite solution, formula (I) compound solution, acid is passed into dynamic tubular reactor, and diazotization reaction occurs under the condition that temperature is not higher than 0 DEG C;Sodium acetate solution, 2-chloroacetoacetic acid ethyl ester solution is passed into microchannel reactor, and Japp-Klingemann reaction occurs with diazotization reaction liquid mixture under the condition that temperature is-5~2 DEG C, concentration, to obtain apixaban intermediate formula (II) compound.The application provides a kind of full continuous flow chemical synthesis method of apixaban intermediate (Z)-2-chloro [(4-methoxyphenyl) hydrazono] ethyl acetate, can be efficiently, high purity, high yield in a few tens of seconds to prepare target product.

The invention provides an application of a citral analogue in enhancing the tolerance of plants to salt stress. The citral analogue is a compound with a structure as shown in formulas I-x, or a salt thereof, or an optical isomer thereof, or a raceme thereof. Experiments verify that a series of known citral analogues and citral analogues with novel structures have the effect of promoting the growth of plant seedling root systems under the salt stress condition for the first time, so that the citral analogues can be prepared into related products, and the citral analogues have great application prospects.