43 results about "Phenylhydrazine" patented technology

The present invention proposes a method and use for stabilizing a simple agglomerate for pH and salt and with adjustable size. In phosphoric acid buffer solutions with different salt concentrations and pH values, the polyacrylic acid hydroxypropyl group condensation body has specific stability; hydrophobic thermal response blocks are introduced into a hydroxypropyl acrylate monomer through reversible addition-fragmentation chain transfer polymerization to regulate and control the size of a condensation body, and a phase separation behavior is shown at different temperatures; a hydrophobic block without thermal response is introduced to regulate and control the size of the aggregate, and no thermal response behavior is shown. Continuous regulation and control of the size of the aggregate from the micron level to the nano level are achieved, and the requirements of different application scenes are met. The hydroxypropyl polyacrylate condensation body can be used for packaging various dyes and drugs; high-efficiency enzyme protection is achieved, formed aggregates can protect glucose oxidase, and the retention rate of enzyme activity reaches 85% or above after treatment is conducted for 3 hours at 60 DEG C; as a micro-reactor for the reaction of generating p-nitrobenzaldehyde phenylhydrazone from p-nitrobenzaldehyde and phenylhydrazine, the reaction rate is greatly improved.

The application discloses a perovskite solar cell based on a 4-carboxyphenylhydrazine hydrochloride modified hole transport layer. A co-self-assembly monolayer is constructed by adding 0.05-0.20 mg / mL of 4-carboxyphenylhydrazine hydrochloride to a Ph-4PACz solution, and the co-assembly behavior of the 4-carboxyphenylhydrazine hydrochloride and the Ph-4PACz is utilized to inhibit the pi-pi stacking aggregation of rigid conjugated groups, repair the long-range ordered charge transport channel in the molecular layer, improve the hole extraction and transport characteristics, and at the same time, the 4-carboxyphenylhydrazine hydrochloride can synergistically passivate the uncoordinated Pb 2+ defects and deep energy level Pb 0 defects, reduce the interface non-radiative recombination loss, and improve the perovskite thin film crystallization quality. The application synchronously optimizes the charge transport characteristics and the interface passivation effect, significantly improves the photoelectric conversion efficiency and the device stability of the perovskite solar cell, and has certain guiding significance for manufacturing large-area perovskite solar cells.

The invention belongs to the technical field of pesticide chemistry, and particularly relates to an application of a substituted phenylhydrazine copper salt complex as an agricultural fungicide, the structural general formula of the substituted phenylhydrazine copper salt complex is [Cu (ArNHNH2) 2] Xn, Ar is selected from 3-chlorphenyl-, 2, 4-dichlorophenyl-, 2, 4-dichlorophenyl-, 2, 4-dichlorophenyl-, 2, 4-dichlorophenyl-, 2, 4-dichlorophenyl-, 2, 4-dichlorophenyl-, 2, 4-dichlorophenyl-, 2, 4-dichlorophenyl-, 2, 4-dichlorophenyl-, the compound is prepared from 2, 6-dichlorophenyl, p-trichloromethoxyphenyl, 4-trifluoromethylphenyl, 4-trifluoromethoxyphenyl, 4-bromophenyl, 4-nitrophenyl, 4-cyanophenyl and 4-carboxyphenyl, and the compound is prepared from 2, 6-dichlorophenyl, p-trichloromethoxyphenyl, 4-trifluoromethylphenyl, 4-trifluoromethoxyphenyl, 4-bromophenyl, 4-nitrophenyl, 4-cyanophenyl and 4-carboxyphenyl. X is selected from SO4 <->, Cl <-> and NO3 <->; n is equal to 1-2. The substituted phenylhydrazine copper salt complex disclosed by the invention has remarkable inhibitory activity on plant pathogenic bacteria, has very high inhibition rate on three plant pathogenic fungi, namely fusarium graminearum, rhizoctonia solani and sclerotium rolfsii, can be used as a safe and efficient novel bactericide, and is applied to prevention and treatment of various crop diseases.

The present disclosure provides a reagent and a method for detecting paraquat in herbicide preparation, the reagent comprising reagent A, reagent B and reagent C, the reagent A being a solution prepared from dipotassium hydrogen phosphate and an alkaline buffer, the reagent B being methanol, and the reagent C being a solution of acetylphenylhydrazine. The method comprises mixing the herbicide preparation to be tested with the reagent A to form a uniform solution A, then adding the reagent B to the uniform solution A, shaking and waiting for phase separation, taking the supernatant B and adding it to the reagent C, immediately visually comparing the color or using a spectrophotometer to compare the color, and determining whether the herbicide preparation to be tested contains paraquat according to the color change. The present disclosure uses acetylphenylhydrazine as a reducing agent combined with solvent to control the redox potential of the reducing agent, develops a detection system specific for reducing paraquat, and applies it to the detection of latent ingredients in herbicide preparations, which has the characteristics of high detection sensitivity, convenient operation and obvious phenomenon, and is suitable for on-site detection.

The invention discloses a synthesis method of 1-(4-chlorphenyl) pyrazolidine-3-ketone, which comprises the following steps: by taking p-chlorophenylhydrazine hydrochloride and acrylamide as raw materials and toluene as a solvent, carrying out azeotropic dehydration under the normal pressure condition, cooling, adding flaky sodium hydroxide or potassium hydroxide, adding acrylamide, carrying out condensation reaction at 40-80 DEG C, filtering, washing and drying to obtain the 1-(4-chlorphenyl) pyrazolidine-3-ketone. And after the reaction is finished, acidifying, desolventizing, crystallizing and filtering to obtain the high-purity 1-(4-chlorphenyl) pyrazolidine-3-ketone. Compared with the prior art, the method provided by the invention has the following advantages: firstly, the inorganic base is adopted to replace the traditional sodium alkoxide organic base, so that the problems of flammability, danger and the like are avoided, and the reaction safety is greatly improved; process conditions are mild, operation steps are simplified, and repeated heating and cooling or negative pressure maintaining are not needed; and thirdly, the process is more environment-friendly, the molecular utilization rate is higher, by-products of alcohols are not generated compared with the traditional process, and the burden of sewage treatment is reduced. Sodium alkoxide is replaced by inorganic base, production cost is saved, and economic benefits are good.

This invention discloses a method for preparing 4-(trifluoromethylsulfinyl)pyrazole compounds, comprising: dissolving terminal alkyne in n-hexane under nitrogen atmosphere, adding anhydrous zinc chloride, and reacting trifluoromethylsulfinyl chloride to obtain α-trifluoromethylalkynyl sulfoxide; adding benzoyl chloride dropwise to a CH2Cl2 solution of phenylhydrazine and triethylamine under nitrogen atmosphere to obtain acylhydrazine; adding carbon tetrachloride to a suspension of acylhydrazine and triphenylphosphine in acetonitrile to obtain hydrazone chloride; and reacting α-trifluoromethylalkynyl sulfoxide, hydrazone chloride, potassium carbonate, and anhydrous ethanol at room temperature to obtain 4-(trifluoromethylsulfinyl)pyrazole compounds. This invention uses inexpensive and readily available raw materials, the entire reaction route is mild and simple to operate, does not require stringent reaction conditions, and most of the reaction process is carried out at room temperature. The product yield is high, and the prepared trifluoromethylalkynyl sulfoxide pyrazole structure has multiple derivatization sites, showing good application prospects.

The application discloses a preparation method and product of a myrtenyl-1,3,4-oxadiazole formylhydrazine compound and application of the compound, and synthesizes myrtenic acid by oxidizing myrtenal; myrtenyl hydrazine is generated by reacting the myrtenic acid with hydrazine hydrate; myrtenyl-1,3,4-oxadiazole methyl ester is generated by reacting the myrtenyl hydrazine with oxalyl chloride methyl ester; the myrtenyl-1,3,4-oxadiazole formylhydrazine compound is generated by reacting the myrtenyl-1,3,4-oxadiazole methyl ester with each substituted phenylhydrazine; the compound has a general formula I: wherein R is H, 4-F, 4-Cl, 4-Br, 4-I, 4-CH3, 2-CH3, 2-F, 3-F, 2-Cl, 3-Cl, 2-Br, 3-Br or 4-OCH3; the compound has good prevention effects on sclerotinia sclerotiorum, botryosphaeria dothidea and fusarium graminearum under an in-vitro condition, and can be used for preventing and treating fungal diseases of agricultural or forestry plants. The preparation method of the compound is simple, the yield is high, and the product is stable in property.

The application belongs to the technical field of molecular biology and drug screening, and provides a method for screening phenylhydrazine sulfate based on a key binding amino acid site of SOCS5-CP and application thereof, which comprises the following steps: key amino acid sites of SOCS5-CP binding are screened through alanine virtual point mutation, and a binding pocket is determined; a ligand molecule is used to perform virtual screening by taking the binding pocket as a docking area, and a compound with the best binding energy is obtained; the obtained drug is screened through AMDET; the selected compound is used for subsequent in-vitro cell experiments, and further screening is performed; the application uses the method of molecular docking and virtual screening in combination with in-vitro experiments for screening, and finds that phenylhydrazine sulfate can be stably combined at the key amino acid sites of SOCS5-CP, in-vitro experiments show that phenylhydrazine sulfate can effectively inhibit the binding of SOCS5-CP, and further down-regulate the protein expression level of HIF1a in hepatoma cells, and also has a significant inhibitory effect on the invasion and migration ability of primary hepatocellular carcinoma.

The application discloses a preparation method of sulfentrazone intermediate, which comprises the following steps: in a solvent, substitution ring-closing reaction of cis-trans isomer compound (nitro hydrazone) shown in formula II and cyanate salt is carried out to generate sulfentrazone intermediate shown in formula III. The scheme provided by the application solves the problems in the prior art, such as the use of a large amount of inorganic reducing agent, such as sodium sulfite, in the production of raw material phenylhydrazine for preparing triazolinone through phenylhydrazine, generation of a large amount of solid waste, and low atomic economy; the scheme solves the problems in the prior art, such as the use of a large amount of sulfite reducing agent and sodium hypochlorite oxidant in the production of raw material phenylhydrazine for preparing triazolinone through phenylhydrazine, generation of a large amount of mixed salt, and low chloro-substitution selectivity of sulfentrazone prepared by using phenylhydrazine as raw material; the scheme solves the problems, such as the reduction of diazonium salt to hydrazine, the oxidation of hydrazine to hydrazine, and the like; the scheme directly utilizes intermediate hydrazine and then utilizes cyanate salt ring-closing, and compared with the prior art, the scheme is shortened by 3 steps, and energy consumption and labor intensity are greatly reduced.

The application belongs to the technical field of microbial preparation of compounds, and provides a phenylhydrazine compound, which has an excellent inhibitory activity on Candida albicans.

The invention belongs to the field of organic chemical synthesis, and relates to a method for synthesizing a natural product Pyrroloazocine indole alkaloid skeleton. According to the method, a commercially available compound 1 and phenylhydrazine are taken as synthesis starting points, and a [2.2. 2] bridge ring system is constructed through key Fischer indole synthesis, Stille coupling reaction and intermolecular Diels-Alder reaction. The preparation method comprises the following steps: carrying out a cyclopropanation reaction mediated by carbene, carrying out a Ley-Griffith oxidation reaction, and carrying out a Beckmann rearrangement and an intramolecular SN2 cyclization cascade reaction so as to realize the construction of the core skeleton of the Pyrroloazocine indole alkaloid. According to the method, a material basis can be provided for activity testing of the Pyrroloazocine indole alkaloid and the analogue thereof, and a thought is provided for synthesis route design of more complex cage-shaped indole alkaloid basic frameworks.

The invention relates to a hole transport layer, a perovskite solar cell and a preparation method, and the method sequentially comprises the following steps: providing a substrate, and preparing a composite hole transport layer on the substrate; depositing an inorganic salt thin film on the composite hole transport layer by adopting a vacuum evaporation method; spin-coating an organic salt solution on the inorganic salt thin film, and then annealing to form a perovskite light absorption layer; preparing a passivation layer on the perovskite light absorption layer; and preparing an electron transport layer, a hole blocking layer and a back electrode in sequence to complete cell preparation. According to the invention, by introducing a'common SAMs' technology (that is, 3, 5-bis (trifluoromethyl) phenylhydrazine hydrochloride is doped into Me-4PACz), the surface property of the hole transport layer is fundamentally improved, and the interface property and the crystallization quality of the thin film are optimized.

This invention relates to the field of chemical synthesis technology, specifically a method for preparing 2,3,3,5-tetramethylindole. The method comprises using p-methylphenylhydrazine hydrochloride and 3-pentanone as raw materials, generating 2,3,3,5-tetramethylindole through a one-step condensation-cyclization reaction in acetic acid medium, followed by further processing steps. This synthetic method offers significant advantages: First, it is highly efficient, with a one-step condensation-cyclization reaction, a molar yield of 60-68%, HPLC endpoint control, and a total processing time of one day, making it suitable for industrial production. Second, it operates under mild conditions, using acetic acid as both solvent and catalyst, with a reaction temperature of 112℃, allowing the use of ordinary enamel-lined reactors and avoiding corrosion from traditional strong acid equipment. Third, it achieves excellent purity, with no isomers and a purity exceeding 99%, offering flexible purification at low cost. Fourth, it is more environmentally friendly, with a dichloromethane recovery rate ≥90%, and wastewater with a near-neutral pH for easy treatment. Fifth, it is easily scaled up, with quantitative formulas for parameters and flexible process adjustments, adaptable to various production fields.

2-alkyl indole due to the unique heterocyclic structure and potential biological activity plays an important role in pharmaceutical chemistry and pharmaceutical industry. The drugs based on alkyl indole skeleton have been reported, which have significant effect in antioxidant, antitumor, antifungal and antibacterial aspects. Its importance is self-evident, because of the wide application of indole skeleton in these aspects, researchers have introduced many selective and economic methods to synthesize this kind of heterocyclic ring, such as phenylhydrazine method, aniline method, o-aminoethyl benzene method, o-chloromethyl benzene method and the like, but these methods have respective defects, such as two-step reaction leading to low yield, catalyst needed for synthesis is not easy to obtain, transition metal catalysis, reaction temperature is far below 0 DEG C and the like, which cannot meet the actual needs. The application develops a general method for synthesizing indole from simple 2-fluorobenzene acetonitrile compound and various alkyl grignard reagent, which is not involved with transition metal and has mild reaction condition.

The invention discloses a method for detecting pyrethroid by using silicon fluoride quantum dots, belongs to the technical field of fluorescence sensing, and designs fluorinated fluorescent silicon quantum dots (FSiQDs) for rapid and visual detection of pyrethroid. The preparation method comprises the following steps: taking fluorophenylhydrazine and N-(beta-aminoethyl)-gamma-aminopropyltrimethoxysilane (DAMO) as raw materials, and reacting at 175-225 DEG C for 4-9 hours to obtain the fluorophenylhydrazine-gamma-aminopropyltrimethoxysilane. Under excitation of 300-400 nm, the fluoro-functionalized silicon quantum dot fluorescent probe emits blue fluorescence (450 nm), fluorescence quenching occurs after the blue fluorescence reacts with pyrethroid hydrolysate 3-phenoxybenzaldehyde (3-PBD), and the quenching rate reaches 75%. The probe has high selectivity and has no interference on common pesticides, metal ions and biomolecules.

A system for the synthesis and evaluation of 3,5-dimethyl-4-(3'-methoxyphenylazo)-1-(4-cyanophenyl)pyrazole, comprising a module for the formation of a 3-[(substituted phenyl)azo]-2,4-pentanedione intermediate and a module for reflux cyclization with 4-cyanophenylhydrazine in ethanol with catalytic acetic acid and a module for TLC-controlled product control and recrystallization.

This invention discloses a hole transport layer and a perovskite solar cell modified with 4-carboxyphenylhydrazine hydrochloride. A co-self-assembled monolayer is constructed by adding 0.05–0.20 mg / mL of 4-carboxyphenylhydrazine hydrochloride to a Ph-4PACz solution. The co-assembly behavior of 4-carboxyphenylhydrazine hydrochloride with Ph-4PACz inhibits the π-π stacking and aggregation of rigid conjugated groups, repairs long-range ordered charge transport channels within the molecular layer, and improves hole extraction and transport characteristics. Simultaneously, 4-carboxyphenylhydrazine hydrochloride can synergistically passivate uncoordinated Pb at the perovskite buried interface. 2+ Defects and deep-level Pb 0 This invention addresses defects, reduces interfacial nonradiative recombination losses, and improves the crystallinity quality of perovskite thin films. By simultaneously optimizing charge transport characteristics and interfacial passivation effects, it significantly improves the photoelectric conversion efficiency and device stability of perovskite solar cells, and also provides guidance for the manufacture of large-area perovskite solar cells.

The invention discloses a design and detection method of a functional modified silicon quantum dot (SiQDs) fluorescent sensor, belongs to the technical field of environmental pollutant detection, and is characterized in that fluorescent silicon quantum dots containing hydrazino functional groups are prepared by doping phenylhydrazine derivatives when traditional silicon quantum dots are prepared. Meanwhile, fluorescent silicon quantum dots with the emission wavelength of 400-700 nm can be prepared by adding different types of fluorescent dyes. The silicon quantum dot has good luminescence property and stability, and especially has good response capability when being used for detecting a pyrethroid hydrolysate 3-phenoxybenzaldehyde.

This invention discloses a method for synthesizing a key intermediate compound of rumepiride and its preparation, belonging to the field of pharmaceutical intermediates technology. This invention discloses for the first time a novel rumepiride-specific key intermediate, 1-(4-fluorophenyl)-4-(4-piperidinone-1-yl)but-1-one, whose structure is precisely adapted to the requirements of constructing the tetracyclic core of rumepiride, exhibiting excellent chemical stability and reactivity. This invention provides two independent preparation processes for γ-hydroxybutyric acid and γ-aminobutyric acid, adaptable to different raw material supply scenarios. The high-purity intermediate is prepared through halogenation, Friedel-Crafts acylation, nucleophilic condensation or double addition, Dickmann condensation, and hydrolysis decarboxylation steps. The process of this invention is simple to operate, has mild conditions, few side reactions, and stable yield. The purity of the prepared intermediate is ≥99.5%, and the impurity index meets the application standards for high-end active pharmaceutical ingredients. It can directly undergo a cyclization reaction with 2-(methylamino)phenylhydrazine to construct the rumepiride nucleus, effectively solving the pain points of existing technologies such as cumbersome processes, low yield, and difficulty in controlling impurities. It fills a technological gap in the industry and has extremely high industrial production value and patent application prospects.

The application belongs to the technical field of pesticide mite killing, and discloses a pesticide composition and application thereof. The pesticide composition comprises active ingredient A and active ingredient B. The active ingredient A is (4'-chloro-6-fluoro-4-methyl-[1,1'-biphenyl]-3-yl)(2,2,2-trifluoroethyl) sulfide. The active ingredient B is any one of spirodiclofen or bifenazate. The mass ratio of the active ingredient A to the active ingredient B is 1:52-45:1. The pesticide composition has good control effect on citrus leaf mite and two-spotted spider mite, is fast-acting, and has long effective period.

The invention relates to a perovskite cell containing a fluorine-containing phenylhydrazine salt doped SAM layer and a preparation method thereof. The perovskite cell sequentially comprises a conductive substrate layer, a fluorine-containing phenylhydrazine salt doped SAM layer and a fluorine-containing phenylhydrazine salt doped SAM layer from bottom to top, the NiOx hole transport layer is arranged on the conductive substrate layer; the SAM mixed layer is arranged on the NiOx hole transport layer, and the SAM mixed layer is a mixed thin film of a fluorine-containing phenylhydrazine salt and a self-assembled monomolecular layer material containing a carbazole group; the perovskite film layer is arranged on the SAM mixed layer; the passivation layer is arranged on the perovskite film layer; the electron transport layer is arranged on the passivation layer; the hole blocking layer is arranged on the electron transmission layer; and the metal electrode is arranged on the hole blocking layer. According to the invention, pentafluorophenylhydrazine is used as a material doped with SAM, so that the photoelectric conversion efficiency of the perovskite solar cell is effectively improved, the stability of the perovskite solar cell is prolonged, and the quality of a buried interface is improved.

The application belongs to the technical field of medicine, and specifically discloses a radiotherapy sensitizer IR808-ATIPA as well as a preparation method and application thereof. The compound is covalently connected by IR808 and ATIPA, has the functions of radiosensitization and CT imaging, and can prolong the retention time in tumors. IR808-ATIPA can enhance X-ray absorption and induce ferroptosis (down-regulate GPX4, up-regulate ACSL4 and ROS) to synergistically improve the effect of radiotherapy. The preparation method comprises the following steps: condensation of phenylhydrazine and 3-methyl-2-butanone to generate an intermediate 1, reaction of the intermediate 1 with 6-bromohexanoic acid to generate an intermediate 2, acyl chloride treatment of the intermediate 2, condensation of the intermediate 2 with triiodoisophthalic acid, and finally reaction and purification of the intermediate 2 with a cyclohexene derivative to obtain the target product. Experiments show that after intratumoral injection of IR808-ATIPA, the micro-CT can guide the radiotherapy target area in real time, and the combination of the micro-CT and low-dose X-ray (4 Gy) can significantly inhibit the growth of tumors and reduce the expression of Ki67. The compound is suitable for tumor treatment with integration of diagnosis and treatment, and has the potential of high biological safety and precise radiotherapy.

The application discloses high-hydrolysis-stability organic borate and a preparation method and application thereof as a lubricating oil additive. 4-formylphenyl boronic acid and phenylhydrazine compounds are added into an ethanol solvent, and stirring is continuously carried out at 80 DEG C for 5-6 hours; after the reaction is completed, the solvent is evaporated to obtain a crude product. The crude product is recrystallized to obtain an intermediate. The intermediate is added into a toluene solvent together with a fatty alcohol, and refluxing reaction is carried out at 110 DEG C for 12-13 hours; after the reaction is completed, the solvent is evaporated to obtain the target product, organic borate. The application solves and improves the problems of low hydrolysis stability, oil solubility and low heat resistance of the organic borate lubricating oil additive.

The invention discloses a UV heating dual-curing adhesive and a preparation method thereof, and belongs to the technical field of adhesives. The UV heating dual-curing adhesive is prepared from the following raw material components in parts by mass: 60 parts of epoxy resin, 30 parts of oxetane, 8 parts of a diluent, 13 to 16 parts of an amine curing agent, 2 parts of a photoinitiator, 2 parts of a thermal initiator, 3 to 6 parts of a toughening modifier and 12 to 18 parts of flame-retardant filler. The amine curing agent is any one or a combination of at least two of 4, 4-diaminodiphenylmethane, 4, 4 '-diaminodiphenyl disulfide and phenylhydrazine; 2, 3, 5, 6-tetrafluorobenzyloxy glycidyl ether is adopted as the toughening modifier, and 2, 3, 5, 6-tetrafluorobenzyloxy glycidyl ether is adopted as the toughening modifier; the flame-retardant filler is prepared by compounding a 9, 10-dihydro-9-oxa-10-phosphaphenanthrene-10-oxide derivative and composite boron nitride, and the flame-retardant filler is prepared by compounding the 9, 10-dihydro-9-oxa-10-phosphaphenanthrene-10-oxide The invention discloses a 9, 10-dihydro-9-oxa-10-phosphaphenanthrene-10-oxide derivative, which is characterized in that the 9, 10-dihydro-9-oxa-10-phosphaphenanthrene-10-oxide derivative is obtained by reacting 9, 10-dihydro-9-oxa-10-phosphaphenanthrene-10-oxide with vinyl imidazole.

The invention discloses a coumarin-based fluorescent probe for high-sensitivity detection of NO2 as well as a preparation method and application of the coumarin-based fluorescent probe, and belongs to the technical field of analytical chemistry and energetic material monitoring. The problems that an existing NO2 fluorescent probe cannot have high sensitivity, high selectivity and good stability at the same time and cannot be suitable for the complex solid / gas phase environment of an NEPE propellant are solved. The structural formula of the coumarin-based fluorescent probe is shown in the specification. The preparation method comprises the following steps: 1, preparing an intermediate product by using a Vilsmeier reagent and an N, N-dimethylformamide solution of 7-dimethylaminocoumarin; and 2, adding phenylhydrazine to carry out condensation reaction. According to the application, a fluorescent probe film sensor is prepared for NO2 detection.

This invention belongs to the field of compound synthesis technology, specifically relating to a method for synthesizing biphenylhydrazine, comprising the following steps: (1) mixing isopropyl chloroformate and hydroxylamine hydrochloride in solvent a, and reacting under certain temperature and alkaline conditions to obtain intermediate 1; (2) mixing intermediate 1 with a hydrocarbon sulfonyl halide in solvent b, and reacting under certain temperature and alkaline conditions to obtain intermediate 2; (3) mixing intermediate 2 with 3-amino-4-methoxybiphenyl in solvent c, and reacting under certain temperature and alkaline conditions to obtain biphenylhydrazine. This invention provides a novel method for synthesizing biphenylhydrazine. The synthesis of biphenylhydrazine in this application uses new raw materials and intermediates, which has the advantages of inexpensive raw materials, short synthesis route, mild reaction conditions, high yield, and ease of industrial production.

This invention discloses the cytotoxic analog N'-biphenylnicotinamide, represented by structural formula I, its pesticide-acceptable salts and pharmaceutical compositions, and its application in the preparation of agricultural fungicides; and the preparation of N'-biphenylnicotinamide derivatives by substituted nicotinic acid and substituted biphenylhydrazine under the action of a condensing agent. Wherein, X is selected from: hydrogen, fluorine, chlorine, bromine, iodine, trifluoromethyl, methyl, or ethyl; Y... 1 Selected from: hydrogen, fluorine, chlorine, bromine, iodine, methyl or ethyl; Y 2 Selected from: hydrogen, fluorine, chlorine, bromine, iodine, methyl or ethyl; Y 3 Selected from: hydrogen, fluorine, chlorine, bromine, iodine, methyl or ethyl; Y 4 Selected from: hydrogen, fluorine, chlorine, bromine, iodine, methyl, ethyl, methoxy, or trifluoromethyl; Y 5 Selected from: hydrogen, fluorine, chlorine, bromine, iodine, methyl or ethyl; Y 6 Selected from: hydrogen, fluorine, chlorine, bromine, iodine, methyl or ethyl.

This invention discloses a 1,2-dibromo-6-tert-butyl-9-(4-tert-butylphenyl)- 9H -Carbazole and its synthetic method. The method uses 3-nitrophthalic acid as a starting material, reacting it with trichloroisocyanuric acid and liquid bromine to obtain 1,2-dibromo-3-nitrobenzene, which is then reduced by stannous chloride to obtain 2,3-dibromoaniline. This is followed by diazotization to obtain 2,3-dibromophenylhydrazine, which is then reacted with p-tert-butylcyclohexanone and dehydrogenated using 2,3-dichloro-5,6-dicyanobenzoquinone to obtain 1,2-dibromo-6-tert-butyl- 9H -Carbazole, which finally reacts with 4-tert-butyliodobenzene to give 1,2-dibromo-6-tert-butyl-9-(4-tert-butylphenyl)- 9H -Carbazole. The 1,2-dibromo-6-tert-butyl-9-(4-tert-butylphenyl)- 9H The presence of the bromine functional group on the -carbazole makes the further transformation of this compound scalable, and it can be used as a material / drug molecule precursor in fields such as organic light-emitting semiconductors and medicinal chemistry.

The invention relates to an electrochemical preparation method for preparing a diaryl selenide compound by using phenylhydrazine and phenylselenol and application of the diaryl selenide compound, and the electrochemical preparation method comprises the following steps: taking a phenylhydrazine compound and a phenylselenol compound as reactants, under the condition that an electrolyte, a non-metal catalyst and an electrolytic solvent are added, driving an oxidation-reduction reaction through electrification to obtain the diaryl selenide compound. The diaryl selenide compound is prepared. Therefore, the phenylhydrazine compound and the phenylselenol compound are used as reactants, compared with traditional halogenated hydrocarbon, the phenylhydrazine has the advantages of being easy to prepare, low in price and the like, the manufacturing cost can be greatly reduced, the use of strong base is avoided, the environmental protection property is further improved, the potential of a transition metal catalyst and a substrate is greatly released, and the method is suitable for industrial production. The reaction conversion can be well ensured, and the product yield is improved.

2-Arylindoles unique heterocyclic structure and recorded biological activity makes it has great application value in medicinal chemistry and pharmaceutical industry. Indole drugs are known to have antioxidant, antitumor, antifungal and antibacterial properties. Because of its wide application, many selective and high economic benefit of synthesis method has been introduced. Such as phenylhydrazine method, aniline method, o-aminoethyl benzene method, o-chlorotoluene method, etc., but these methods have their own shortcomings, such as two-step reaction leading to low yield, synthesis needs catalyst not easy to get, need transition metal catalysis, reaction temperature is far below 0 DEG C, not easy to scale production, etc. The purpose of the present application is to provide a kind of solution to the above problems, simple, economic and more widely applicable or suitable for scale production of 2-arylindole compound synthesis method. Here, we report a general method for the synthesis of indole from simple 2-fluorobenzene acetonitrile compound and various aryl Grignard reagent, which does not involve transition metal and the reaction condition is mild.