28results about How to "High insecticidal activity" patented technology

The invention discloses an isoxazoline compound as shown in a formula (I) and application thereof. R1, R2 and R3 can be selected from halogen atoms, cyano groups, nitryl groups, C1-C3 halogenated alkyl groups and the like; q can be independently selected from A1 to A6; l1 and L2 may be selected from a carboxyl group, a C1-C6 alkoxycarbonyl group, a hydroxyl-substituted C1-C8 alkyl group, and the like; z1, Z2 may be selected from a hydrogen atom, a C1-C6 alkyl group, a C3-C5 cycloalkyl group, or C (O) M, wherein M is a C1-C6 alkyl group, a C2-C6 alkenyl group, or the like; the isoxazoline compound provided by the invention has no cross resistance with existing insecticides, has the advantages of quick pesticide effect, low dosage and the like, and particularly has an excellent control effect on rice-resistant chilo suppressalis, plutella xylostella, aphid and the like. The invention also provides an isoxazoline compound as a pesticide acceptable salt, a composition and an application of the isoxazoline compound. # imgabs0 #

The invention discloses an indole sophocarpidine derivative photoaffinity active molecular probe which is formed by connecting an active group and a reactive group, the active group is a sophocarpidine derivative, the reactive group is a substance containing a diaziridine group and an alkyne group, and the chemical formula of the sophocarpidine derivative is as shown in the formula I. The invention further discloses a preparation method of the indole sophocarpidine derivative photoaffinity active molecular probe. After Spodoptera frugiperda Sf9 cells are treated by the indole sophocarpidine derivative photoaffinity active molecular probe for 72 hours, the inhibition rate can reach 86.33%, potential target protein when the sophocarpidine derivative acts on the Sf9 cells can be determined by utilizing the indole sophocarpidine derivative photoaffinity active molecular probe, targeted modification of sophocarpidine is facilitated, and the application range of the indole sophocarpidine derivative photoaffinity active molecular probe is widened. Further, matrine pesticides with excellent insecticidal activity are efficiently synthesized, and agricultural pests are better prevented and controlled.

The invention relates to an isoxazoline derivative as well as a preparation method and application thereof, and belongs to the technical field of medicine synthesis. Specifically, the invention discloses an isoxazoline derivative as shown in a general formula (I), a pharmaceutical composition containing the derivative and application of the isoxazoline derivative and the pharmaceutical composition in preparation of anti-parasitic drugs. The structural general formula (I) of the isoxazoline derivative is # imgabs0. The isoxazoline derivative disclosed by the invention has a remarkable effect in the aspects of resisting parasites, vector insects, agricultural and forestry pests and the like, and has a wide application prospect.

The invention discloses a method for synthesizing a 4-sulfonyl-2,5-bis(trifluoromethyl)oxazole compound, wherein a sulfonylmethyl isonitrile derivative is used as a substrate, trifluoroacetic anhydride is used as a fluorine source, and copper catalysis is used to react in a solvent under alkaline conditions to synthesize a 4-sulfonyl-2,5-bis(trifluoromethyl)oxazole compound. The synthetic method has the advantages of simple operation, diversified products, and one-pot efficient synthesis of products that are not easily obtained by other methods.

The invention discloses an isoxazoline hybridized neolignan compound as well as a preparation method and application of the isoxazoline hybridized neolignan compound. The neolignan compound disclosed by the invention is one of isoxazoline magnolol, isoxazoline honokiol, isoxazoline nitrated magnolol and isoxazoline nitrated honokiol derivatives, and has the following chemical general formula: # imgabs0. The neolignan compound disclosed by the invention takes one of magnolol, honokiol, nitrated magnolol or nitrated mangnolia officinalis as a raw material; the preparation method comprises the following steps: by taking triethylamine as alkali and dichloromethane as a solvent, carrying out 1, 3-dipolar cycloaddition reaction on a raw material and alpha-chlorooxime, and separating and purifying to obtain the isoxazoline hybridized neolignan compound. The compound disclosed by the invention has relatively good insecticidal activity on plutella xylostella Linnaeus and Mythimna separata Walker, can be used for preparing a novel efficient insecticide, and is applied to prevention and treatment on the plutella xylostella Linnaeus and the Mythimna separata Walker.

The present invention discloses a bisamide compound containing isoxazoline, a preparation method and a use thereof, wherein the structural formula is as follows (I), wherein: R 1 , R 2 , R 3 is hydrogen, halogen, cyano, nitro, C1-C6 alkyl, C1-C6 haloalkyl or C1-C6 haloalkoxy; R 4 is hydrogen, halogen, cyano, nitro, C1-C6 alkyl or C1-C6 haloalkyl; R 5 is hydrogen, halogen, nitro, hydroxyl, amino, mercapto, C1-C6 alkoxy, C1-C6 alkenyl, C1-C6 cycloalkyl or C1-C6 aryl; R 6 is a halogen atom, a cyano group, a nitro group, a C1-C6 alkyl group, a C1-C6 cycloalkyl group or a C1-C6 aryl group; M is; wherein R 7 is halogen, ‑CN, ‑NO2, ‑CH3, ‑CH2CH3, ‑CH2CH2CH3, ‑CH2CH2CH2CH3, ‑C(CH3)3, etc.; Z is O, S. The invention has a good insecticidal effect on lepidopteran pests such as fall armyworm.

The invention discloses a triazoloquinazolinone compound and its application, and belongs to the technical field of pesticides. The triazoloquinazolinone compound has excellent inhibitory activity and excellent insecticidal activity on chitinase, especially has high inhibitory activity on chitinase h of Asian corn borer; and has strong insecticidal activity on agricultural pests corn borer and diamondback moth. The compound can be used as chitinase inhibitor or insecticide, has high pesticide research value, and has broad application prospects in the field of pesticide science.

The present invention relates to the technical field of pesticides, and relates to an efficient use method of Metarhizium reinhardtii Mr006, which is applied to the prevention and control of lepidopteran pests such as fall armyworm. Metarhizium reinhardtii Mr006 is mixed with chlorantraniliprole, and on the basis of clarifying the compatibility of the two, it is found that the treatment of first bacteria and then medicine, and first medicine and then bacteria have excellent control effects on fall armyworm, and the combination of the two has an excellent synergistic effect, achieving the purpose of improving the insecticidal activity of Metarhizium reinhardtii Mr006 and reducing the amount of chlorantraniliprole; at the same time, the effect of taking both quick-acting and lasting effects into consideration is achieved, providing ideas for pest resistance management, and providing a basis for long-term green control of fall armyworm populations.

This invention discloses a method for preparing and applying a coumaric acid-modified MOF nanopesticide loaded with chlorantraniliprole, belonging to the field of pesticide formulation technology. The nanopesticide comprises: an iron-based metal-organic framework carrier MIL-101(Fe); chlorantraniliprole loaded within the pores of the carrier; and coumaric acid modified on the surface of the carrier through electrostatic interactions. The preparation method includes three steps: MIL-101(Fe) carrier synthesis, chlorantraniliprole loading, and coumaric acid surface modification. The process is simple and the conditions are mild. This invention utilizes the alkaline environment of the fall armyworm's gut to trigger carrier degradation, achieving targeted and controlled release of active molecules. Simultaneously, the released MIL-101(Fe) is reduced under the action of GSH in the gut, generating reactive oxygen species through the Fenton reaction, forming a synergistic insecticidal effect with coumaric acid. Experiments have shown that this nanopesticide exhibits far superior insecticidal activity against fall armyworm compared to single agents or carriers, possessing excellent insecticidal activity and environmental compatibility, making it suitable for green agricultural production.

The invention discloses a truncated Vip3Af protein and application thereof.The transgenic plant obtained by genetic transformation of the truncated Vip3Af protein can express the Vip3Af protein in a high-dose mode, meanwhile, the phenotype of the transgenic plant is not remarkably different from that of conventional non-transgenic corn, the purpose of reducing the toxicity of the Vip3Af protein to plant cells is achieved, and the transgenic plant can be applied to the field of plant growth. And the insecticidal activity of the Vip3Af protein is not different from that of the original Vip3Af protein. Meanwhile, a section of polypeptide is fused at the N terminal of the truncated Vip3Af protein, and the Vip3Af protein transcribed and expressed in plant cells is guided into chloroplast, so that the toxicity of the Vip3Af protein to the plant cells is further reduced, and a transgenic plant with higher expression quantity of the Vip3Af protein, better insect-resistant activity and no influence on plant phenotype can be obtained. The problems that in the prior art, Vip3Af protein is high in toxicity and low in expression quantity are solved.

The invention belongs to the technical field of microbial pesticides, and discloses a bacillus thuringiensis ZYLT064 with efficient insecticidal activity on cotton aphid and tetranychus urticae and application of the bacillus thuringiensis ZYLT064. The preservation number of the strain in the China Center for Type Culture Collection (CCTCC) is CCTCC NO: M 20242335; the strain can generate insecticidal active substances of bacillus thuringiensis and trans-aconitic acid, fermented supernate of the strain shows remarkable insecticidal activity on cotton aphids and tetranychus urticae, the fatality rate of the cotton aphids biologically tested by feeding in a laboratory reaches 87%, the fatality rate of the tetranychus urticae is 80.9%, and the fatality rate of the tetranychus urticae biologically tested by potting in a greenhouse reaches 72.5%. Therefore, the strain disclosed by the invention has the potential of being developed into a multifunctional biological control product and has a wide application prospect.

The invention provides a novel glycosyl C-glycoside thiadiazoline derivative as well as a preparation method and application thereof, and belongs to the field of pesticides. The structural formula is shown as a formula (I) or a formula (II). According to the invention, the glycosyl carbon glycoside compound with a novel structure is synthesized by taking the insect chitin degrading enzyme as a biological target. The glycosyl C-glycoside compound or the pharmaceutically acceptable salt thereof has good target enzyme inhibition activity and insecticidal activity, and the insecticidal activity of part of the compound to plutella xylostella and ostrinia nubilalis is equivalent to that of a control agent diflubenzuron. The compound disclosed by the invention has a very high pesticide research value. # imgabs0 #

The present invention provides: an agricultural / horticultural insecticide composition which contains an insecticidal protein derived from Bacillusthuringiensis, and prumycin or a salt thereof or kanosamine or a salt thereof; or a method for controlling agricultural / horticultural insect pests which uses said agricultural / horticultural insecticide composition.

The invention discloses a coumarin derivative and an acaricide, and belongs to the technical field of agricultural pest control. The structural formula of the coumarin derivative is shown as a formula (I), and is recorded as COUM-N; r1, R2, R3 and R4 in the formula (I) are selected from H, halogen, methoxyl or hydroxyl, and at least one of R1, R2, R3 and R4 is selected from halogen, methoxyl or hydroxyl. The coumarin derivative disclosed by the invention has good target enzyme inhibition activity and insecticidal activity. # imgabs0 #

The present invention discloses an insecticide synergistic composition containing a piperic acid derivative compound and an application thereof. The composition consists of two active ingredients, compound A and compound B, wherein the active component A is compound I-72; the active component B is selected from any one of indoxacarb, s-indoxacarb or metaflumizone; the compound I-72 has the following structure: The composition of the present invention has the advantages of obvious synergy, delayed resistance, etc., and can be used for preventing and controlling lepidopteran and coleopteran pests on agriculture, forestry and ornamental plants, especially for use on resistant striped stem borer and resistant diamondback moth.

The present application relates to a kind of arylamino-containing xanthine derivatives and its preparation method and application.On the basis of 1,3-disubstituted xanthine raw material, arylamino-containing xanthine derivatives obtained by series of reactions are shown as general formula I.Compounds of general formula I have higher herbicidal activity, and have obvious activity on rape, amaranthus retroflexus, barnyard grass, crabgrass, have good insecticidal activity, especially on the effect of diamondback moth is remarkable, have good fungicidal activity, and have obvious in vitro inhibitory activity on wheat scab fungus, pepper phytophthora blight fungus, sclerotinia sclerotiorum, cucumber fusarium wilt fungus, apple phialophora quercina, wheat sharp eyespot fungus, etc.Compounds of general formula I can be used as active components of herbicidal or insecticidal or fungicidal composition, for preparing agricultural herbicide or insecticide or fungicide, and can be used for the prevention and treatment of grass damage or insect damage or pathogenic damage on various crops.Also have good inhibitory effect on the activity of KARI, and can be used for KARI inhibitor.

The invention relates to application of isoalantolactone or a derivative thereof as a pesticide synergist in aphid prevention and control, low-concentration isoalantolactone has a remarkable synergistic effect on chemical pesticides, 2 mu g / ml isoalantolactone and 25% thiamethoxam are mixed for use, the lethal medium concentration of thiamethoxam on four aphids can be remarkably reduced, and the killing effect of the thiamethoxam on the aphids is remarkably improved. The insecticidal activity of thiamethoxam on aphids is improved. Field efficacy tests also show that after 50% recommended dosage of 48% clothianidin or 22% sulfoxaflor is mixed with 3 [mu] g / ml of isoalantolactone for use, the insect decline rate and the control effect on corn aphids and rhopalosiphum padi are equivalent to those of 100% recommended dosage of the 48% clothianidin or 22% sulfoxaflor respectively, and after the 48% clothianidin or 22% sulfoxaflor is mixed with 3 [mu] g / ml of isoalantolactone. Therefore, the isoalantolactone not only remarkably improves the field insecticidal activity of the pesticide to the corn aphid and the rhopalosiphum padi, but also reduces the pesticide consumption by 50%, achieves the purposes of pesticide reduction and synergism, and has a positive effect on comprehensive prevention and control of field pests.

The invention discloses application of thuringirin in prevention and treatment of cotton aphid, green peach aphid, armyworm and soybean cyst nematode, and belongs to the field of microbial pesticides. The invention discovers that the thurinin has the biological activity of killing cotton aphid, green peach aphid, mythimna separata and soybean cyst nematode for the first time, has a wide application prospect, and can be developed into a novel environment-friendly biological control agent.

This invention relates to the field of pyrethroid synthesis methods, particularly a method for preparing highly efficient cis-cyhalothrin, especially focusing on the epimer separation and activity enhancement process. The method uses 3-phenoxy-4-fluorobenzaldehyde as a raw material, adds dichloroquine chloride (cis-acyl chloride) dropwise to prepare cis-cyhalothrin, and then uses cyclohexane, n-heptane, and isopropanol as solvents, and diisopropylamine-triethylamine and a novel ZnCl2-TPP metal complex as catalysts to carry out an epimerization reaction to obtain highly efficient cis-cyhalothrin. After adjusting the pH to neutral, the product is filtered to obtain a crude highly efficient cis isomer. The crude product is recrystallized from methanol and vacuum dried to obtain the technical grade of highly efficient cis-cyhalothrin. This invention provides an epimerization process in the preparation method of highly efficient cis-cyhalothrin, which has the advantages of high conversion efficiency, short conversion time, and high purity of the technical grade.

The invention belongs to the technical field of medical fertilizers, and particularly relates to an African tephrosia margarita biogas slurry liquid insecticidal organic medical fertilizer and a preparation process thereof. The pesticide fertilizer is prepared from the following raw materials: biogas slurry, tephrosia africana, microbial flora, a water-soluble separant and a plant growth regulator. The preparation process comprises the following steps: harvesting mature African tephrosia chinensis plants, drying and crushing the plants, adding the crushed plants, microbial flora, a plant growth regulator and a water-soluble separant into biogas slurry, and carrying out vibration soaking extraction in the biogas slurry for 10-15 days through ultrasonic waves to obtain the African tephrosia chinensis biogas slurry liquid insecticidal organic pesticide fertilizer. According to the method, the biogas slurry and the African tephrosia tephrosia are adopted as substrates, the multifunctional African tephrosia tephrosia biogas slurry organic medical fertilizer is obtained through fermentation, the multifunctional African tephrosia tephrosia biogas slurry organic medical fertilizer is directly sprayed to leaf surfaces of corn plants, nutrient substances are evenly distributed, the utilization rate is high, preparation and application are simple and easy to implement, the insecticidal and fertilizing effects are remarkable, and compared with chemical pesticides and chemical fertilizers, the multifunctional African tephrosia tephrosia biogas slurry organic medical fertilizer is free of pollution to

The present invention discloses a multi-element nanoformulation for improving the sensitivity of bean thrips to drugs, and a preparation method and application thereof, and studies a hydrophilic-lipophilic diblock polymer (HLDP) and a targeted Nrf2 SUL / HLDP / ds Nrf2 Compound, for SUL / HLDP / ds Nrf2 The delivery efficiency of the complex in vivo and in vitro and the effect of SUL / HLDP / ds on the Nrf2 The insecticidal activity of the complex was tested and confirmed Nrf2 Regulation of pesticide detoxification and metabolism in BFTs, down-regulation Nrf2 It can inhibit the expression of most detoxification genes and reduce enzyme activity. SUL / HLDP / ds Nrf2 The complex showed high drug delivery efficiency and insecticidal activity both in vitro and in vivo, with a field efficacy of 89.89% against BFTs.

The invention relates to an arylamino-containing xanthine derivative as well as a preparation method and application thereof. On the basis of a 1, 3-disubstituted xanthine raw material, the xanthine derivative containing the arylamino group, which is obtained through a series of reactions, is shown as a general formula I in the specification. The compound of the general formula I has high herbicidal activity, and has obvious activity on rape, amaranthus retroflexus, barnyard grass and digitaria sanguinalis. The compound has good insecticidal activity, and especially has a remarkable effect on plutella xylostella. The compound has good bactericidal activity, and has obvious in-vitro inhibitory activity on fusarium graminearum, phytophthora capsici, sclerotinia sclerotiorum, fusarium wilt of cucumber, physalospora piricola, rhizoctonia cerealis and the like. The compound as shown in the general formula I can be used as an active component of a weeding or insecticidal or bactericidal composition, is used for preparing an agricultural herbicide or insecticide or bactericide, and can be used for preventing and treating weeds, pests or germs on various crops. The compound also has a good inhibition effect on the activity of KARI, and can be used as a KARI inhibitor. # imgabs0 #

The invention provides a mandelonitrile and isothiocyanate compound insecticidal composition, a preparation and application of the mandelonitrile and isothiocyanate compound insecticidal composition and the preparation. The isothiocyanate is at least one selected from the group consisting of allyl isothiocyanate, ethyl isothiocyanate, n-propyl isothiocyanate, phenyl isothiocyanate, benzyl isothiocyanate, 1-phenyl ethyl isothiocyanate and 2-phenyl ethyl isothiocyanate; the mass ratio of the mandelonitrile to the isothiocyanate is (1-16): (100-1). The composition disclosed by the invention is used for preparing a fumigant for preventing and treating warehouse pests, root-knot nematodes in soil and pine wood nematodes on pine trees, has an obvious fumigating effect on pests such as grain pests, soil nematodes and pine wood nematodes, has an obvious synergistic effect and is relatively small in dosage.

The invention belongs to the technical field of pesticides, and particularly relates to a preparation method and application of a pyrido [1, 2-a] pyrimidone compound containing a 1, 3, 4-oxadiazole thioether unit. The compound is shown as a general formula I, wherein R1 independently represents alkyl, aryl, heterocyclic group and the like; and R2 independently represents hydrogen, alkyl, halogen, or the like. R3 independently represents a methyl group, an ethyl group, an aryl group, a heterocyclic group or the like; the compound has a good prevention and treatment effect on plant hoppers, aphids and the like.

The application relates to the technical field of pesticides, and discloses a cyclic dinucleotide compound, an agonist, application of the cyclic dinucleotide compound and a medicament. The cyclic dinucleotide compound has a structure as shown in formula I, formula II or formula III. The cyclic dinucleotide compound provided by the application has selective antifeeding activity on insects and good insecticidal activity.

The invention discloses a fusion protein for preventing and treating cowpea resistant lepidoptera pests and application thereof.The fusion protein of Cry1Ab and mutated Vip3Af is screened out, insecticidal proteins Cry and Vip3 in the fusion protein are expressed at the same time in plants, it is beneficial for the insect-resistant protein to exert biological activity, and the effect of preventing and treating cowpea resistant lepidoptera pests is achieved. The risk of occurrence of pest resistance in nature is effectively relieved, and resistant lepidoptera pests are efficiently prevented and treated. Compared with the existing insecticidal protein cowpea, the cowpea for expressing the insecticidal fusion protein provided by the invention has higher insecticidal activity on lepidoptera pests.

The present invention discloses a multi-element nanocomposite for controlling pesticide resistance of peach aphid, and its preparation method and application, clarifies the key regulatory role of the nuclear transcription factor erythroid 2-related factor 2 (nrf2)-small Maf protein (sMaf) pathway in broad-spectrum insecticide metabolic resistance, and proves nrf2 and sMaf Simultaneous downregulation can further inhibit the expression of detoxification genes, reduce the activity of detoxification enzymes, and provide a nearly spherical multi-component nanoprotectant IMI / HLDP / ds with a particle size of 256 nm. nrf2 ‑ sMaf The root absorption test showed that the insecticidal activity of the complex was through simultaneous inhibition of nrf2 and sMaf The normalized synergistic ratio was 1.65-2.29 times higher than that of nrf2-sMaf. This study elucidated the key regulatory role of the nrf2-sMaf pathway in the broad-spectrum metabolic resistance of peach aphid and developed a self-assembled multi-component nanoprotectant to achieve sustainable management of the broad-spectrum metabolic resistance of peach aphid.

The invention discloses a chitinase inhibitor as well as preparation and application thereof, and belongs to the technical field of biology. The invention finds that the compound with the structure of the general formula (I) has high enzyme inhibition activity and excellent insecticidal activity on chitinase, especially has high inhibition activity on Asiatic corn borer chitinase h (OfChih), and has strong insecticidal activity on agricultural pests such as corn borer and plutella xylostella. The compound with the structure can be used for chitinase inhibitors or insecticides, has a very high pesticide research value, and has a wide application prospect in the field of agricultural pharmacology.