Coumarin derivative and acaricide

By designing coumarin derivatives combined with the L-type calcium ion channel of cinnabar spider mite, the existing acaricide resistance and inefficiency are solved, and the efficient acaric effect on cinnabar spider mite is achieved.

CN119285595APending Publication Date: 2025-01-10SOUTHWEST UNIV
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Patent Information

Application Number
CN202411503737.5
Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Filing Date
2024-10-25
Publication Date
2025-01-10

AI Technical Summary

Technical Problem

The existing acaricides are resistant to cinnabar spider mites and lack effective natural alternatives, making it difficult to significantly kill pests at low concentrations.

Method used

A series of coumarin derivatives were designed to enhance their effect on calcium ion channels by replacing coumarin fragments with L-type calcium ion channel (L-VGCC) of cinnabar spider mite, and developed good targets and killing. New acaricides for insect activity.

Benefits of technology

The significant acaric activity against cinnabar spider mite was achieved, especially at low concentrations to activate the L-type calcium ion channel, resulting in the death of nerve convulsions of the pest, proving that L-VGCC is a new target for selective acaricidal effect.

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Abstract

The invention discloses a coumarin derivative and an acaricide, and belongs to the technical field of agricultural pest control. The structural formula of the coumarin derivative is shown as a formula (I), and is recorded as COUM-N; r1, R2, R3 and R4 in the formula (I) are selected from H, halogen, methoxyl or hydroxyl, and at least one of R1, R2, R3 and R4 is selected from halogen, methoxyl or hydroxyl. The coumarin derivative disclosed by the invention has good target enzyme inhibition activity and insecticidal activity. # imgabs0 #
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Citation Information

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