443 results about "Oxazole" patented technology

Provided herein are polymorphs and crystalline forms of 2-fluoro-5-((5S,5aS,6S,9R)-1-fluoro-12-(((2R,7aS)-2-fluorotetrahydro-1H-pyrrolizin-7a(5H)-yl)methoxy)-5-methyl-5a,6,7,8,9,10-hexahydro-5H-4-oxa-3,10a,11,13,14-pentaaza-6,9-methanonaphtho[1,8-ab]heptalen-2-yl)-3-methyl-4-(trifluoromethyl)aniline (Compound of Formula (I)), pharmaceutical compositions thereof, and methods of their use, for example, in the treatment of cancer. Also provided herein are synthetic processes for the manufacture of a compound of Formula (I) (i.e., 2-fluoro-5-((5S,5aS,6S,9R)-1-fluoro-12-(((2R,7aS)-2-fluorotetrahydro-1H-pyrrolizin-7a(5H)-yl)methoxy)-5-methyl-5a,6,7,8,9,10-hexahydro-5H-4-oxa-3,10a,11,13,14-pentaaza-6,9-methanonaphtho[1,8-ab]heptalen-2-yl)-3-methyl-4-(trifluoromethyl)aniline). Also provided are compounds useful in its synthesis (e.g., those of Formulae (A), (B), (By), and (H)) and synthetic processes directed thereto.

The invention relates to the field of cables, and discloses a modified polyvinyl chloride composite material for cables and a preparation method thereof.The composite material comprises low-density polyethylene, polyvinyl chloride, ethylene-vinyl acetate copolymer, nitrile rubber, modified graphene oxide, modified nano calcium carbonate and auxiliaries; the modified graphene oxide is prepared by reacting acylating chlorination of graphene oxide with an anti-aging derivative, the anti-aging derivative is prepared by reducing a benzoxazole-containing intermediate generated by a reaction of 2-amino-4-bromophenol and 4-cyanobenzaldehyde to obtain an aminated benzoxazole-containing intermediate, then the aminated benzoxazole-containing intermediate reacts with p-phenylenediamine, and then the product reacts with 3-(3, 4-dichlorophenyl)-1, 2, 3-triazole-3-one to obtain the anti-aging graphene oxide. 2, 5-di-tert-butyl-4-hydroxyphenyl) propionyl chloride is subjected to a reaction to prepare the product. And the modified nano calcium carbonate is prepared by reacting phosphonitrilic chloride trimer with an amino silane coupling agent and 2-amino benzoxazole-5-borate and then grafting on the surface of the nano calcium carbonate. The composite material prepared by the invention has excellent flame retardance, heat resistance and long-acting oxidation resistance.

The invention discloses a copolyimide film with low dielectric constant and low thermal expansion coefficient and a preparation method thereof, and the preparation method comprises the following steps: reacting 0.019-0.021 mol of aromatic dianhydride and 0.017-0.023 mol of diamine unit in 0.45-0.48 mol of solvent, then adding 0.0004 mol of end-capping reagent dissolved in 0.13-0.15 mol of solvent, and reacting to prepare polyamide acid with a main chain containing o-hydroxyl; the diamine unit comprises 10-40 mol% of a monomer with a main chain containing o-hydroxyl and the balance of aromatic diamine; performing film coating and thermal imidization on polyamide acid to prepare a polyimide film; and heating to carry out thermal rearrangement reaction on the o-hydroxyl to obtain the copolyimide film with the main chain containing the oxazole ring. The dielectric constant of the prepared copolyimide film is 2.7-3.0, and the thermal expansion coefficient of the copolyimide film is 19.5-26.5 ppm / K.

The invention relates to the technical field of antiepileptic drugs, in particular to a 2-methyloxazole derivative as well as a preparation method and application thereof. The structural general formula of the 2-methyloxazole derivative is shown in the specification. The 2-methyloxazole derivative provided by the invention has remarkable histamine H3 receptor antagonistic activity and shows an anti-convulsion characteristic, so that the 2-methyloxazole derivative can be used as an anti-epileptic compound. Compared with a compound 1 of the patent application CN115784983B, the 2-methyloxazole derivative provided by the invention has a better anti-epileptic effect under the dosage of 30mg / kg, can completely resist convulsion of a tested mouse, and solves the problem that the existing compound is still insufficient to completely resist convulsion attack. # imgabs0 #

The invention provides a sodium ion battery as well as a preparation method and application thereof, and belongs to the technical field of battery materials. The sodium ion battery comprises a positive electrode, a negative electrode and an electrolyte, the positive electrode is a sodium-supplemented positive plate treated by a biphenyl sodium complex solution; the electrolyte comprises a NaPF6 basic electrolyte and an additive; and the additive is selected from at least one of 3-trimethylsilyl-2-oxazolidinone and N, N-dimethyl formamide. The resistance and capacity of the positive electrode are improved by supplementing sodium to the positive electrode, and the charge-discharge cycle life of the battery is prolonged by adding a polar reagent into the electrolyte to capture PF5 and remove trace water and harmful gas HF generated in charge and discharge.

The invention discloses a P.megaterium strain with stress resistance, growth promotion and environmental restoration functions and application thereof, and belongs to the technical field of microorganisms. According to the present invention, the preservation number of the Pristeria megaterium XT106 provided by the invention is CCTCC (China Center For Type Culture Collection) NO: M 2025912, and the preservation number of the Pristeria megaterium XT106 provided by the invention is CCTCC NO: M 2025912; the Pristia megaterium XT106 provided by the invention is a strain capable of oxidizing manganese to form a biological manganese oxide, and the biological manganese oxide can adsorb and remove heavy metals (Cu, Sb, Pb, Zn, Cd and Cr) and degrade antibiotics (tetracycline and ciprofloxacin). The strain can move, tolerate acid-base, high-salt, phenanthrene and sulfamethoxazole environments, has the capability of generating a biological membrane, and can generate hydrogen sulfide, adsorb / fix and remove heavy metals (Cd, Pb, Zn, Sb and Cu) and promote plant growth.

Formula (I): JPEG2025536322000043.jpg74140 (in the formula, L, R 1 , R 2 , R 3 and W is as defined in the specification. and their enantiomers, diastereomers, racemates, tautomers, prodrugs, hydrates, solvates and pharmaceutically acceptable salts are useful in the treatment of diseases and conditions affected by the inhibition of Mer kinase, such as cancer.

The invention relates to the technical field of microbial treatment of antibiotic pollution, and discloses an antibiotic degrading bacterium with salt tolerance and capable of degrading sulfamethoxazole at low temperature and application, the strain degrades SMX in a wide temperature range of 10-40 DEG C, the degradation rate of 20mg / L SMX at 10-35 DEG C within 64 hours is greater than 70%, and the degradation rate of 20mg / L SMX at 20-30 DEG C reaches 100%; at the low temperature of 10 DEG C, low-concentration SMX is obviously degraded, and the SMX with the concentration of 5 mg / L can be completely degraded within 16 hours; the MJ2 can still effectively degrade SMX under the harsh conditions that the temperature is low and SMX serves as the unique carbon and nitrogen source, the degradation rate reaches 100% after 66h at the concentration of 5 mg / L, and it is proved that the MJ2 has the unique oligotrophic adaptability. Salinity tests show that the degradation rate of MJ2 to 20 mg / L SMX within 48 hours under the 0.1-2% NaCl concentration is 100%, the degradation rate is still kept at 50% even under the stress of 3% high salt, and remarkable salt tolerance is also shown. In conclusion, the strain MJ2 integrates wide temperature range adaptability, low-temperature high efficiency, oligotrophic tolerance and high salt stability, and has great application value in sulfonamide antibiotic pollution remediation in a complex environment.

The invention discloses an anti-ultraviolet automobile window film and a preparation method thereof, and relates to the field of high polymer materials. When the anti-ultraviolet automobile window film is prepared, methylcyclotetrasiloxane, octamethylcyclotetrasiloxane, 3-glycidyl propyl (dimethoxy) methylsilane and 1, 3-bis (3-aminopropyl)-1, 1, 3, 3-tetramethyldisiloxane are subjected to a reaction, and modified polysiloxane is prepared; the preparation method comprises the following steps: reacting benzo [1, 2-d: 5, 4-d '] bis (oxazole)-2, 6-dithiol with 4-aminobenzoyl chloride to prepare a modified ultraviolet absorbent; isophorone diisocyanate, polytetrahydrofuran ether glycol, the modified polypyrrole particles, the modified polysiloxane and the modified ultraviolet absorbent are subjected to a reaction, and the reaction product is spread in a mold. The anti-ultraviolet automobile window film prepared by the invention has good anti-ultraviolet, heat-insulating, flame-retardant and anti-aging properties and good mechanical properties.

The invention belongs to the technical field of medicinal chemistry, and particularly relates to a 2-aminopyrimidine compound, application thereof and an antitumor drug. The 2-aminopyrimidine compound provided by the invention has a structure as shown in a formula (I). According to the invention, 2-aminopyrimidine is used as a mother nucleus structure, and a series of 2-aminopyrimidine compounds are successfully constructed by accurately introducing a biologically active imidazole, thiazole or oxazole nitrogen-containing heterocyclic ring fragment at the 5 # site of 2-aminopyrimidine; systematic in-vitro anti-tumor activity evaluation proves that the 2-aminopyrimidine compound with the structure as shown in the formula (I) provided by the invention shows remarkable inhibitory activity on various tumor cell lines, and the activity of part of the compound is even superior to that of a clinical control drug. The structural diversity of 2-aminopyrimidine compounds is enriched, valuable lead compounds are provided for developing novel efficient antitumor drugs, and the 2-aminopyrimidine compounds have important scientific significance and clinical transformation potential. # imgabs0 #

The preparation method comprises the following steps: taking para aminobenzoic acid, 3, 3-diaminobiphenyl and phosphorus pentoxide as raw materials, and carrying out high-temperature dehydration cyclization reaction in a polyphosphoric acid solvent to obtain a diamine monomer containing biimidazole; the preparation method comprises the following steps: adding a bis-imidazole-containing diamine monomer, 2-(4-aminophenyl)-5-aminobenzoxazole and an organic solvent into a reactor, stirring and dissolving, after the solution is clarified, adding pyromellitic dianhydride, stirring and reacting, and after the reaction is completed, obtaining a polyamide acid membrane casting solution; and carrying out film casting on the polyamide acid film casting solution, drying at low temperature, and transferring to a muffle furnace to carry out imidization reaction after solvent volatilization is finished, so as to obtain the bis-imidazole polyimide film. The biimidazole polyimide film constructed by the invention is applied to a flexible OLED substrate, and has relatively good thermal performance and mechanical performance.

The invention relates to the field of biological medicine, in particular to a construction method of a novel marine source 4-hydroxybenzoxazole-2 (3H)-thioketone carrier based on a beta-cyclodextrin metal organic framework and application of the novel marine source 4-hydroxybenzoxazole-2 (3H)-thioketone carrier to antibacterial activity enhancement. According to the invention, the effect of 4-hydroxybenzoxazol-2 (3H)-thioketone (HBOT) on resisting escherichia coli and shigella flexneri is found. The result shows that the antibacterial diameter of the HBOT on shigella flexneri is 15.78 + / -0.67 mm, and the antibacterial diameter of the HBOT on escherichia coli is 10.81 + / -0.50 mm; the MIC of the free HBOT to shigella flexneri is 128 [mu] g / mL, and the MIC of the beta-CD-MOF loaded with the free HBOT is 64 [mu] g / mL, so that the beta-CD-MOF loaded with the free HBOT has the capability of enhancing the antibacterial performance.

The invention discloses an iron-loaded sulfonated carbon nitride heterogeneous catalyst as well as a preparation method and application thereof, and belongs to the field of heterogeneous catalysts. The iron-loaded sulfonated carbon nitride heterogeneous catalyst consists of monatomic Fe and a sulfonated graphite phase carbon nitride carrier, so that the prepared iron-loaded sulfonated carbon nitride heterogeneous catalyst can catalyze the reaction of benzoxazole and absolute ethyl alcohol, is high in catalytic efficiency, can catalyze the reaction of benzimidazole or benzothiazole and absolute ethyl alcohol, and is high in catalytic efficiency. Therefore, 2-(1-hydroxyethyl)-benzimidazole or 2-(1-hydroxyethyl)-benzothiazole is synthesized, and concentrated acid does not need to be used as a catalyst in the synthesis process. The sulfonation degree of the iron-loaded sulfonated carbon nitride heterogeneous catalyst can be regulated and controlled, the iron-loaded sulfonated carbon nitride heterogeneous catalyst can catalyze the construction of a directional C-C bond, and the iron-loaded sulfonated carbon nitride heterogeneous catalyst keeps stable in the reaction process and can be recycled for 5 times or more.

The invention discloses a ZIF-based catalytic ceramic membrane, a preparation method and application of the ZIF-based catalytic ceramic membrane in water treatment, and belongs to the technical field of environmental functional materials and membrane separation. According to the method, a bimetallic precursor solution and an organic ligand solution are adopted, ZIF crystals grow on a ceramic membrane in situ, and then the ZIF-based catalytic ceramic membrane with Co-Co metallic bond and Co-N coordination double active sites is prepared through high-temperature pyrolysis and acid pickling treatment. The prepared ZIF-based catalytic ceramic membrane has high porosity (the specific surface area is greater than or equal to 360 m < 2 > / g) and strong binding force, can stably operate for 3720 minutes or more in a continuous flow reaction, has a removal rate of up to 90% for electronic-enriched pollutants such as sulfamethoxazole and the like, and can resist water quality interference. The process is simple, active sites are controllable, and the method is suitable for high-efficiency low-consumption treatment of industrial wastewater.

The invention provides an oxazomycin high-yield engineering strain as well as a construction method and application thereof. The method for constructing the oxazomycin high-yield engineering strain comprises the following steps: driving high expression of a gene cluster by using a strong promoter in streptomyces longsheng, enhancing transcription of a key resistance gene module (ozmS-oxaA), and optimizing ribosome engineering of strain chassis cells and a culture medium. According to the invention, the rational synthetic biology and metabolic engineering technology is combined with the irrational ribosome engineering technology to gradually increase the yield of the streptomyces longsheng oxazomycin, and the established efficient biosynthesis system lays a foundation for further development of the oxazomycin.

The invention discloses a high-load monatomic catalyst as well as a preparation method and application thereof. The monatomic catalyst is an iron monatomic catalyst, and is characterized in that the mass loading proportion of Fe can be regulated and controlled within the range of 5.16-41.31 wt%, which exceeds all Fe monatomic catalysts reported at present, and overcomes the bottleneck of few metal active sites of the monatomic catalyst. The method has the advantages that a cascade anchoring strategy is adopted, and Fe < 3 + > is assembled into a macromolecular organic framework through the multifunctional effect of a chelating agent. And calcining the obtained precursor in N2 atmosphere at 550 DEG C for 4 hours to obtain the high-quality loaded iron monatomic catalyst. The preparation method is simple, low-cost and environment-friendly. The prepared monatomic catalyst with the high iron loading capacity has more active sites, the activation performance of potassium hydrogen persulfate is remarkably improved, the degradation kinetics of sulfamethoxazole (SMX) is improved, the SMX removal rate of 90% or above can still be kept after the catalyst is repeatedly used for five times, and it is indicated that the catalyst has good activity and durability.

The invention belongs to the technical field of electrolyte, and particularly relates to electrolyte and a secondary battery. The electrolyte comprises a water-removing and acid-inhibiting additive, the mass percent of the water-removing and acid-inhibiting additive is 0.05%-2.2% by taking the total mass of the electrolyte as 100%, the water-removing and acid-inhibiting additive comprises compounds with structures shown in a formula II and a formula III, the compound with the structure shown in the formula II is 3-ethyl-2-methyl-2-(3-methylbutyl)-1, 3-oxazolidine, and the compound with the structure shown in the formula III is 3-ethyl-2-methyl-2-(3-methylbutyl)-1, 3-oxazolidine. The compound with the structure as shown in the formula III is 3-butyl-2-(1-ethyl amyl)-1, 3-oxazolidine. The mass ratio of the compound with the structure shown in the formula II to the compound with the structure shown in the formula III is (1: 2)-(1: 4). The formula II and the formula III are compounded according to the proportion of (1: 2)-(1: 4), the overall performance of the additive can be synergistically optimized, the formula II provides rapid initial acid inhibition response, and the formula III ensures lasting later protection, so that the long-acting period from formation to long-term circulation of the battery is covered.

The invention discloses a preparation method of 3-chloro-5, 5-dimethyl-4, 5-dihydroisoxazole, which comprises the following steps: taking a hydroxylamine oxygen sulfonic acid aqueous solution and isopentenal as raw materials, carrying out oximation reaction in an organic solvent under an alkaline condition, then directly adding an acid or an organic base catalyst into the reaction system, and reacting for 2-4 hours to obtain 3-chloro-5, 5-dimethyl-4, 5-dihydroisoxazole, thereby obtaining the 3-chloro-5, 5-dimethyl-4, 5-dihydroisoxazole. Under the catalytic action of the catalyst, a cyclization reaction is carried out, after the reaction is finished, an intermediate solution containing 5, 5-dimethyl-4, 5-dihydroisoxazole is obtained, and the next step is directly carried out; and carrying out a chlorination reaction by taking the intermediate solution as a raw material and sodium hypochloride or chlorine as a chlorination reagent, and after the reaction is finished, carrying out post-treatment to obtain the 3-chloro-5, 5-dimethyl-4, 5-dihydroisoxazole. The hydroxylamine oxygen sulfonic acid is used for enabling the isopentenal to be subjected to oximation reaction under the alkaline condition, then cyclization is carried out under the catalytic action of acid or alkali, the 5, 5-dimethyl-4, 5-dihydroisoxazole is generated, and the process has the advantages that the yield is high, the production steps are simplified, and the production cost is reduced.

The invention belongs to the technical field of organic synthesis, and particularly relates to a synthesis method of an isoxazole compound under a visible light catalysis condition. The method comprises the following steps: dissolving a compound 1 in 1, 2-dichloroethane, then adding tert-butyl nitrite, tribromomethane, alkali and a photocatalyst, in an inert gas environment, irradiating with visible light and stirring at room temperature to react, after the reaction is completed, reducing pressure to remove a solvent, and then performing silica gel column purification on a crude product to obtain a product, namely the isoxazole compound. The brand-new method for preparing the isoxazole compound through visible light catalysis is developed, the conditions of high temperature and high pressure in a traditional synthesis method are avoided, energy consumption and environmental pollution are remarkably reduced, and the yield of the isoxazole compound is effectively increased by regulating and controlling reaction conditions and optimizing raw material selection and proportion.

The present invention discloses a method for degrading sulfamethoxazole using QXT-31-Mn, which belongs to the field of sewage treatment technology. QXT-31-Mn was deposited with the General Microbiology Center of the China Culture Collection Administration on December 3, 2024, with the deposit number CGMCC No. 32889 and the deposit address at No. 3, Yard 1, Beichen West Road, Chaoyang District, Beijing. The taxonomic name is Arthrobacter sp. The present invention utilizes QXT-31-Mn to produce a safer and more environmentally friendly cathode material that can efficiently degrade SMX.

The disclosure relates to compounds of Formula I or a pharmaceutically acceptable salt thereof, wherein, m, R1-R5, R5A, and L are defined herein. These compounds are useful in methods for stabilizing a mutant PAH protein or reducing blood phenylalanine concentration in a subject suffering from phenylketonuria. In some embodiments, the mutant PAH protein contains at least one R408W, R261Q, R243Q, Y414C, L48S, A403V, I65T, R241C, L348V, R408Q, or V388M mutation. In other embodiments, the mutant PAH protein contains at least one R408W, Y414C, I65T, F39L, R408Q, L348V, R261Q, A300S, or L48S mutation.

The invention discloses a preparation method of an inorganic piezoelectric catalytic membrane and application of the inorganic piezoelectric catalytic membrane in water treatment by coupling an advanced oxidation technology, and belongs to the technical field of environmental functional materials and water treatment. Technical breakthrough is achieved through a synergistic mechanism of an inorganic piezoelectric material and an advanced oxidation technology, the inorganic piezoelectric catalytic membrane is prepared by taking the piezoelectric material as a core piezoelectric component through ball-milling mixing, dry-pressing forming and high-temperature calcination processes, a multi-stage pore channel structure (the pore diameter is 50-100 nm) is formed, and a piezoelectric electric field larger than or equal to 0.5 V is generated under dynamic mechanical energy; the electric field is used for directionally activating the oxidant to generate high-selectivity singlet oxygen (1O2) by adjusting an electron structure on the surface of the catalyst, and the selectivity of the singlet oxygen reaches 95% or above; the mass transfer efficiency is remarkably improved through the synergistic effect of the membrane confinement effect and the piezoelectric micro-current, efficient removal of refractory pollutants such as sulfamethoxazole and bisphenol A is achieved (the degradation rate within 30 minutes is larger than or equal to 99%), and the self-cleaning function is achieved (the flux recovery rate is larger than or equal to 98%).

The invention relates to the technical field of waterproof coiled materials, in particular to an anti-ultraviolet SBS waterproof coiled material and a preparation method thereof.The waterproof coiled material comprises a base layer, an anti-ultraviolet SBS asphalt layer and a thin film layer, the anti-ultraviolet SBS asphalt layer comprises asphalt, an SBS elastomer, asphalt softening oil, an anti-aging waterproof multifunctional agent, composite filler, an initiator and the like, and the thin film layer is prepared from the following components; the anti-aging waterproof multifunctional agent prepared by the invention takes macromolecular polysiloxane as a main chain and simultaneously contains a double hindered amine structure and a benzoxazole structure, and the benzoxazole structure not only can cooperate with a polysiloxane structure to improve the thermal aging resistance of a material, but also can endow a coiled material with a rigid structure; the double hindered amine structure has better ultraviolet aging resistance and does not influence the improvement of silicon-oxygen bonds on the waterproof performance of the coiled material, and the functional agent can make the asphalt coiled material become a coiled material resistant to thermal aging, ultraviolet aging and chemical substance erosion.

The invention discloses a halohydrin dehalogenase mutant and application of the halohydrin dehalogenase mutant in preparation of (R)-4-phenyl-2-oxazolidinone, and belongs to the technical field of enzyme engineering and chemical engineering, amino acid residues of wild type halohydrin dehalogenase are mutated, and the halohydrin dehalogenase mutant with high enzyme activity and high stereoselectivity is screened out. The halohydrin dehalogenase mutant provided by the invention has high enzyme activity and high stereoselectivity in the application of catalyzing (S)-2-phenyl ethylene oxide to be converted into (R)-4-phenyl-2-oxazolidinone, the catalytic efficiency of the mutant T126L / F170M can reach 1.7 times of that of wild halohydrin dehalogenase, and the halohydrin dehalogenase mutant has extremely high industrial application value.

The invention discloses a synthesis method of an oxazole derivative, and belongs to the technical field of chemical synthesis. The oxazole derivative is synthesized from a ketone ester compound and thiourea through a one-pot method, the required raw materials are cheap and easy to obtain, the experimental operation is simple, the reaction condition is mild, a metal catalyst and other reagents are not needed, and the defects that a metal catalysis synthesis method is used, for example, the catalyst is high in price, the reaction synthesis route steps are many, and the synthesis cost is low are overcome. The method has the advantages of mild reaction conditions, low reaction rate, unstable intermediate, low yield and the like, bypasses most complex synthesis steps of a metal-free catalytic synthesis method, and develops a simple, efficient, green and environment-friendly way for synthesizing the oxazole derivative. Under mild conditions, ketone ester substrates with different substituent groups have very strong compatibility, and a new green synthesis way is provided for synthesis of substituted oxazole.

Provided are: a resin composition containing a resin selected from the group consisting of polyimides and polybenzoxazoles, and a compound having an alkynyl group; a cured product obtained by curing the resin composition and a production method therefor; a laminate containing the cured product and a production method therefor; a semiconductor device and a production method therefor; and a novel compound.

The invention discloses a blended neutron / gamma discrimination polysiloxane scintillator and a preparation method thereof. The polysiloxane scintillator is composed of a matrix, a primary fluorescent dye, a secondary fluorescent dye and a cross-linking agent. A matrix of the scintillator is a copolymer of methyl phenyl polysiloxane and phenyl methyl siloxane, a main fluorescent dye is 2, 5-diphenyl oxazole (PPO), a secondary fluorescent dye is selected from 7-diethylamino-4-methylcoumarin (MDAC), and a cross-linking agent is 1, 3-divinyl-1, 3-diphenyl-1, 3-dimethyl siloxane. The obtained polysiloxane scintillator has good stability and can be used for neutron detection and neutron / gamma discrimination in a strong irradiation field environment.

The application provides a synthesis process of metrafenone, in which inorganic alkali KOH is used as a catalyst, a key intermediate 4-(((5,5-dimethyl-dihydroisoxazole-4-yl)thio)methyl)-1-methyl-3-(trifluoromethyl)-1H-pyrazol-5-ol can be obtained at low production cost and high yield, metrafenone is prepared through substitution reaction and oxidation reaction, the reaction yield is high, raw materials are simple and easy to obtain, three-waste emissions are small, and the process is beneficial to industrial mass production.

The present invention relates to a composition in the form of a water-in-oil emulsion, comprising: a) at least one oily continuous phase comprising at least one volatile oil chosen from volatile hydrocarbon oils, volatile silicone oils and their mixtures, and b) at least one aqueous phase dispersed in said oily phase, the amount of water being greater than or equal to 20% by weight, with respect to the total weight of the composition, and c) at least one hydrophobic film-forming polymer, and d) at least one emulsifying surfactant chosen from polyoxyalkylenated linear polydimethylmethylsiloxanes with an HLB ≤ 8.0, and e) at least 3.0% by weight of a vitamin B3 and / or one of its derivatives, with respect to the total weight of the composition, said composition not containing a water-soluble organic UV screening agent comprising at least one benzylidenecamphorsulfonic acid group nor a water-soluble organic UV screening agent comprising at least one benzoxazolesulfonic acid group.