603 results about "Oxazole" patented technology

Provided herein are polymorphs and crystalline forms of 2-fluoro-5-((5S,5aS,6S,9R)-1-fluoro-12-(((2R,7aS)-2-fluorotetrahydro-1H-pyrrolizin-7a(5H)-yl)methoxy)-5-methyl-5a,6,7,8,9,10-hexahydro-5H-4-oxa-3,10a,11,13,14-pentaaza-6,9-methanonaphtho[1,8-ab]heptalen-2-yl)-3-methyl-4-(trifluoromethyl)aniline (Compound of Formula (I)), pharmaceutical compositions thereof, and methods of their use, for example, in the treatment of cancer. Also provided herein are synthetic processes for the manufacture of a compound of Formula (I) (i.e., 2-fluoro-5-((5S,5aS,6S,9R)-1-fluoro-12-(((2R,7aS)-2-fluorotetrahydro-1H-pyrrolizin-7a(5H)-yl)methoxy)-5-methyl-5a,6,7,8,9,10-hexahydro-5H-4-oxa-3,10a,11,13,14-pentaaza-6,9-methanonaphtho[1,8-ab]heptalen-2-yl)-3-methyl-4-(trifluoromethyl)aniline). Also provided are compounds useful in its synthesis (e.g., those of Formulae (A), (B), (By), and (H)) and synthetic processes directed thereto.

The invention relates to a composite phase-change film based on liquid metal and PBO fiber and a preparation method thereof, and belongs to the technical field of phase-change material preparation, and the preparation method comprises the following steps: the composite phase-change film comprises a poly (p-phenylbenzobisoxazole) fiber (PBO) base material, a phase-change material and a heat-conducting filler, the phase-change material is composed of phase-change microcapsules (PM) which are prepared by taking polyurethane (PU) as a wall material and organic solid-liquid phase-change materials (OPCMs) as a core material through a Pickering emulsion polymerization method. The prepared PM has a core-shell structure, and leakage of OPCMs is effectively prevented. The PM and the PBO fiber network are combined, so that the dual packaging of the OPCMs is realized, and the leakage of the OPCMs is further prevented. Meanwhile, dispersion and interaction of the OPCMs in a PBO matrix are optimized, and formation of a network structure with a limited domain is promoted. The composite phase change film prepared by the invention has relatively high mechanical properties, remarkable heat conductivity, excellent and stable flexibility and excellent heat storage capacity.

The invention discloses a preparation method of antistatic modified chinlon filaments, and relates to the field of chinlon filaments. When the antistatic modified chinlon filament is prepared, (formylmethyl) diethyl phosphate and 1-aminopyrrole react to prepare pyrrole diethyl phosphate; reacting the hydroxylated multi-walled carbon nanotube with pyrrole diethyl phosphate to obtain a modified multi-walled carbon nanotube; the preparation method comprises the following steps: reacting 2, 2 '-bipyridine-5, 5'-dicarboxylic acid with 2-amino-5-nitrophenol, and then reducing to obtain a benzoxazole diamine monomer; then, adipic acid, 1, 5-diaminopentane and a benzoxazole diamine monomer are subjected to a reaction, and modified polyamide is prepared; uniformly mixing the modified polyamide, the modified multi-walled carbon nanotubes, pyrrole, ferric trichloride and copper chloride, and performing melt spinning to obtain the antistatic modified polyamide filament. The antistatic modified chinlon filament prepared by the invention has excellent antistatic, flame-retardant, anti-aging and mechanical properties.

The present disclosure relates to pharmaceutical compositions suitable for oral administration, and more particularly to pharmaceutical compositions, including pharmaceutical tablet compositions, containing (2S)-N-{(1S)-1-cyano-2-[4-(3-methyl-2-oxo-2,3-dihydro-1,3-benzoxazol-5-yl)phenyl]ethyl}-1,4-oxazepane-2-carboxamide (Compound A) or a pharmaceutically acceptable salt thereof.

The invention relates to the technical field of three-proofing paints, in particular to a UV moisture dual-curing three-proofing paint and a preparation method thereof. The conformal coating is prepared from the following raw materials in parts by weight: 10-80 parts of acrylate resin; 20 to 60 parts of a UV reactive diluent; 3-15 parts of a polyurethane latent curing agent; 1 to 10 parts of a photoinitiator; 1-5 parts of a dewatering agent; the acrylic resin comprises at least one of urethane acrylate and isocyanate modified acrylate. According to the invention, when the specific curing agent is selected, especially the oxazolidine latent curing agent or imine latent curing agent containing at least two oxazolidinyl groups is adopted, the curing time of the conformal coating in a dark environment can be greatly shortened, and meanwhile, the problems of bubbles, pinholes and the like caused by moisture in the curing process of the conformal coating can be effectively solved; good market application values are realized.

The invention relates to the field of cables, and discloses a modified polyvinyl chloride composite material for cables and a preparation method thereof.The composite material comprises low-density polyethylene, polyvinyl chloride, ethylene-vinyl acetate copolymer, nitrile rubber, modified graphene oxide, modified nano calcium carbonate and auxiliaries; the modified graphene oxide is prepared by reacting acylating chlorination of graphene oxide with an anti-aging derivative, the anti-aging derivative is prepared by reducing a benzoxazole-containing intermediate generated by a reaction of 2-amino-4-bromophenol and 4-cyanobenzaldehyde to obtain an aminated benzoxazole-containing intermediate, then the aminated benzoxazole-containing intermediate reacts with p-phenylenediamine, and then the product reacts with 3-(3, 4-dichlorophenyl)-1, 2, 3-triazole-3-one to obtain the anti-aging graphene oxide. 2, 5-di-tert-butyl-4-hydroxyphenyl) propionyl chloride is subjected to a reaction to prepare the product. And the modified nano calcium carbonate is prepared by reacting phosphonitrilic chloride trimer with an amino silane coupling agent and 2-amino benzoxazole-5-borate and then grafting on the surface of the nano calcium carbonate. The composite material prepared by the invention has excellent flame retardance, heat resistance and long-acting oxidation resistance.

The invention discloses a copolyimide film with low dielectric constant and low thermal expansion coefficient and a preparation method thereof, and the preparation method comprises the following steps: reacting 0.019-0.021 mol of aromatic dianhydride and 0.017-0.023 mol of diamine unit in 0.45-0.48 mol of solvent, then adding 0.0004 mol of end-capping reagent dissolved in 0.13-0.15 mol of solvent, and reacting to prepare polyamide acid with a main chain containing o-hydroxyl; the diamine unit comprises 10-40 mol% of a monomer with a main chain containing o-hydroxyl and the balance of aromatic diamine; performing film coating and thermal imidization on polyamide acid to prepare a polyimide film; and heating to carry out thermal rearrangement reaction on the o-hydroxyl to obtain the copolyimide film with the main chain containing the oxazole ring. The dielectric constant of the prepared copolyimide film is 2.7-3.0, and the thermal expansion coefficient of the copolyimide film is 19.5-26.5 ppm / K.

The invention relates to the technical field of silane modified polymers, in particular to silane-terminated polyether polymer resin and a preparation method thereof.The preparation method comprises the following steps that firstly, polyether polyol and a solvent are mixed, the temperature is increased to 60-70 DEG C under the protection of nitrogen gas, diisocyanate and a catalyst A are added, a reaction is conducted for 12-24 h, and isocyanate-terminated polyether is obtained; and 2, mixing epoxy siloxane, isocyanate-terminated polyether, a catalyst B and imidazole, heating to 150-160 DEG C under the protection of nitrogen gas, and carrying out heat preservation reaction for 8-10 hours to obtain the silane-terminated polyether polymer resin. The silane modified polyether with a carbamate and oxazolidinone five-membered heterocyclic structure is obtained through reaction of diisocyanate, polyether polyol and epoxy siloxane, the cohesion of the silane modified polyether can be effectively enhanced, and the mechanical property, the adhesive property and the high-temperature persistent adhesion stability of the silane-terminated polyether polymer resin are improved.

The invention relates to the technical field of antiepileptic drugs, in particular to a 2-methyloxazole derivative as well as a preparation method and application thereof. The structural general formula of the 2-methyloxazole derivative is shown in the specification. The 2-methyloxazole derivative provided by the invention has remarkable histamine H3 receptor antagonistic activity and shows an anti-convulsion characteristic, so that the 2-methyloxazole derivative can be used as an anti-epileptic compound. Compared with a compound 1 of the patent application CN115784983B, the 2-methyloxazole derivative provided by the invention has a better anti-epileptic effect under the dosage of 30mg / kg, can completely resist convulsion of a tested mouse, and solves the problem that the existing compound is still insufficient to completely resist convulsion attack. # imgabs0 #

Described herein are crystalline forms of 6-(6-(((1R,2R,3S,5S)-2-fluoro-9-azabicyclo[3.3.1]nonan-3-yl)(methyl)amino)pyridazin-3-yl)-2-methylbenzo[d]oxazol-5-ol (compound A), a small molecule splicing modulator (SMSM) of mRNA, such as pre-mRNA, encoded by genes, for the treatment of Huntington's disease.

The invention relates to the technical field of photoelectricity, in particular to a light conversion agent based on a benzoxazole skeleton and a preparation method and application of the light conversion agent. The invention provides a light conversion agent based on a benzoxazole skeleton. The light conversion agent comprises an organic compound taking benzoxazole as a parent. According to the light conversion agent based on the benzoxazole skeleton, the problems that an existing light conversion agent is low in ultraviolet light absorption efficiency, and the photoelectric conversion efficiency of a prepared light conversion adhesive film is low are solved.

The invention provides a sodium ion battery as well as a preparation method and application thereof, and belongs to the technical field of battery materials. The sodium ion battery comprises a positive electrode, a negative electrode and an electrolyte, the positive electrode is a sodium-supplemented positive plate treated by a biphenyl sodium complex solution; the electrolyte comprises a NaPF6 basic electrolyte and an additive; and the additive is selected from at least one of 3-trimethylsilyl-2-oxazolidinone and N, N-dimethyl formamide. The resistance and capacity of the positive electrode are improved by supplementing sodium to the positive electrode, and the charge-discharge cycle life of the battery is prolonged by adding a polar reagent into the electrolyte to capture PF5 and remove trace water and harmful gas HF generated in charge and discharge.

The invention provides a boron-containing plastic scintillator and a preparation method thereof, the boron-containing plastic scintillator comprises the following raw materials by mass: 20%-40% of 2, 5-diphenyloxazole: styrene, 0.1%-0.5% of 7-diethylamino-4-methylcoumarin: styrene, 1%-10% of divinylbenzene: styrene, 0.1%-0.2% of azodiisobutyronitrile: styrene, and the balance of water. The ratio of m-carborane or o-carborane to styrene is 1%-5%. The preparation method comprises the following steps: S1, adding styrene into a container in an inert atmosphere, and introducing inert gas into the container; s2, in an inert atmosphere, adding other raw materials into the container, performing ultrasonic stirring, heating the raw materials in the container to 50 DEG C at the same time, performing heat preservation at 50 DEG C for 72 hours, performing stepped heating for three times to 70 DEG C, performing heat preservation at 70 DEG C for 72 hours, and then performing cooling to room temperature to obtain the boron-containing plastic scintillator. The cross-linking agent is added into the plastic scintillator, so that the plastic scintillator is harder in texture, not prone to deformation, stable and transparent in performance and capable of working normally at the temperature of 60 DEG C, the durability is obviously improved, and the applicable environment is more.

Described herein is 6-(6-(((lR,2R,3S,5S)-2-fluoro-9- aza bicyclo[ 3.3.1 ]nonan-3-y l)(methyl)a mino) pyridazin-3-y l)-2- methylbenzo[d]oxazol-5-ol (structure B) as a small molecule splicing modulator (SMSM) of mRNA, such as pre-mRNA, encoded by genes, for the treatment of neurological and neurodegenerative diseases, such as e.g. Huntigton's disease, and brain cancer.

The invention discloses a P.megaterium strain with stress resistance, growth promotion and environmental restoration functions and application thereof, and belongs to the technical field of microorganisms. According to the present invention, the preservation number of the Pristeria megaterium XT106 provided by the invention is CCTCC (China Center For Type Culture Collection) NO: M 2025912, and the preservation number of the Pristeria megaterium XT106 provided by the invention is CCTCC NO: M 2025912; the Pristia megaterium XT106 provided by the invention is a strain capable of oxidizing manganese to form a biological manganese oxide, and the biological manganese oxide can adsorb and remove heavy metals (Cu, Sb, Pb, Zn, Cd and Cr) and degrade antibiotics (tetracycline and ciprofloxacin). The strain can move, tolerate acid-base, high-salt, phenanthrene and sulfamethoxazole environments, has the capability of generating a biological membrane, and can generate hydrogen sulfide, adsorb / fix and remove heavy metals (Cd, Pb, Zn, Sb and Cu) and promote plant growth.

Formula (I): JPEG2025536322000043.jpg74140 (in the formula, L, R 1 , R 2 , R 3 and W is as defined in the specification. and their enantiomers, diastereomers, racemates, tautomers, prodrugs, hydrates, solvates and pharmaceutically acceptable salts are useful in the treatment of diseases and conditions affected by the inhibition of Mer kinase, such as cancer.

The invention relates to the technical field of microbial treatment of antibiotic pollution, and discloses an antibiotic degrading bacterium with salt tolerance and capable of degrading sulfamethoxazole at low temperature and application, the strain degrades SMX in a wide temperature range of 10-40 DEG C, the degradation rate of 20mg / L SMX at 10-35 DEG C within 64 hours is greater than 70%, and the degradation rate of 20mg / L SMX at 20-30 DEG C reaches 100%; at the low temperature of 10 DEG C, low-concentration SMX is obviously degraded, and the SMX with the concentration of 5 mg / L can be completely degraded within 16 hours; the MJ2 can still effectively degrade SMX under the harsh conditions that the temperature is low and SMX serves as the unique carbon and nitrogen source, the degradation rate reaches 100% after 66h at the concentration of 5 mg / L, and it is proved that the MJ2 has the unique oligotrophic adaptability. Salinity tests show that the degradation rate of MJ2 to 20 mg / L SMX within 48 hours under the 0.1-2% NaCl concentration is 100%, the degradation rate is still kept at 50% even under the stress of 3% high salt, and remarkable salt tolerance is also shown. In conclusion, the strain MJ2 integrates wide temperature range adaptability, low-temperature high efficiency, oligotrophic tolerance and high salt stability, and has great application value in sulfonamide antibiotic pollution remediation in a complex environment.

The invention relates to the technical field of display, in particular to a deuterated oxazole ring organic compound and application thereof. The deuterated oxazole ring organic compound provided by the invention has the following general formula structure: # imgabs0 # is based on the structure of a formula (1), and deuterium atoms are introduced into the compound as shown in the formula (1), so that the stability of the organic compound can be effectively improved, and the service life of a device is further prolonged; the position of the deuteration is further limited, so that the HOMO and LUMO energy levels of the organic compound are well matched with adjacent energy levels, the carrier mobility is well balanced, and the device has the advantages of low voltage and high efficiency while having long service life; in conclusion, the deuterated oxazole ring organic compound provided by the invention has excellent properties, so that the prepared organic light-emitting device has the characteristics of low driving voltage, high light-emitting efficiency and long service life.

The invention belongs to the field of photocatalytic organic synthesis of new energy materials, and discloses a covalent organic framework material, a transition metal complex and covalent organic framework composite photocatalytic material and application. The covalent organic framework material is a covalent organic framework material connected by imine bonds and synthesized by 4, 4 ', 4' ', 4 '''-(benzo [1, 2-d: 4, 5-d '] bis (oxazole)-2, 4, 6, 8-tetrayl) tetraphenylamine and an aldehyde group-containing monomer in the presence of a first solvent and a catalyst by adopting a solvothermal method. The covalent organic framework material disclosed by the invention exerts the characteristic of being beneficial to light energy absorption, forms a unique metal coordination environment while improving light responsiveness, and is beneficial to efficient photocatalysis of carbon dioxide reduction under the synergistic effect of doping the material into metal ions.

The invention relates to a magnetic calcium-iron layered double-metal hydroxide catalyst as well as preparation and application thereof. The catalyst is characterized in that the catalyst is composed of a carrier and layered double hydroxides, the layered double hydroxides are calcium-iron layered double hydroxides, and the carrier is magnetic copper ferrite CuFe2O4; wherein the loading mass percentage of Ca element in the catalyst is 8-16%, and the molar ratio of Ca < 3 + > to Fe < 2 + > is (2-4): 1. Through a specific hydrothermal synthesis method, the catalyst capable of effectively activating PMS to efficiently degrade sulfamethoxazole (SMX) in water is prepared. The preparation process of the catalyst comprises synthesis of copper and iron oxides and subsequent combination of calcium and iron layered double hydroxides, the process not only improves the catalytic efficiency, but also optimizes recovery and recycling of the catalyst through introduction of a magnetic material.

The invention discloses an anti-ultraviolet automobile window film and a preparation method thereof, and relates to the field of high polymer materials. When the anti-ultraviolet automobile window film is prepared, methylcyclotetrasiloxane, octamethylcyclotetrasiloxane, 3-glycidyl propyl (dimethoxy) methylsilane and 1, 3-bis (3-aminopropyl)-1, 1, 3, 3-tetramethyldisiloxane are subjected to a reaction, and modified polysiloxane is prepared; the preparation method comprises the following steps: reacting benzo [1, 2-d: 5, 4-d '] bis (oxazole)-2, 6-dithiol with 4-aminobenzoyl chloride to prepare a modified ultraviolet absorbent; isophorone diisocyanate, polytetrahydrofuran ether glycol, the modified polypyrrole particles, the modified polysiloxane and the modified ultraviolet absorbent are subjected to a reaction, and the reaction product is spread in a mold. The anti-ultraviolet automobile window film prepared by the invention has good anti-ultraviolet, heat-insulating, flame-retardant and anti-aging properties and good mechanical properties.

The invention provides a preparation method of 3-(3-bromine-2-methyl-6-methylsulfonyl phenyl)-4, 5-dihydroisoxazole, and the preparation method comprises the following steps: (1) reacting 2, 3-dimethyl-4-methylsulfonyl bromobenzene with an oximation reagent to obtain a 3-bromine-2-methyl-6-methylsulfonyl benzaldoxime reaction solution; (2) mixing the 3-bromine-2-methyl-6-methylsulfonyl benzaldoxime reaction solution obtained in the step (1) with a chlorination reagent to react, so as to obtain a 3-bromine-2-methyl-6-methylsulfonyl benzaldoxime acyl chloride reaction solution; and (3) carrying out a ring closing reaction on the 3-bromo-2-methyl-6-methylsulfonyl benzoxime acyl chloride reaction solution obtained in the step (2) and ethylene, so as to obtain the 3-(3-bromo-2-methyl-6-methylsulfonyl phenyl)-4, 5-dihydroisoxazole. The preparation method is simple in operation steps, high in yield and suitable for industrial production.

The invention belongs to the technical field of medicinal chemistry, and particularly relates to a 2-aminopyrimidine compound, application thereof and an antitumor drug. The 2-aminopyrimidine compound provided by the invention has a structure as shown in a formula (I). According to the invention, 2-aminopyrimidine is used as a mother nucleus structure, and a series of 2-aminopyrimidine compounds are successfully constructed by accurately introducing a biologically active imidazole, thiazole or oxazole nitrogen-containing heterocyclic ring fragment at the 5 # site of 2-aminopyrimidine; systematic in-vitro anti-tumor activity evaluation proves that the 2-aminopyrimidine compound with the structure as shown in the formula (I) provided by the invention shows remarkable inhibitory activity on various tumor cell lines, and the activity of part of the compound is even superior to that of a clinical control drug. The structural diversity of 2-aminopyrimidine compounds is enriched, valuable lead compounds are provided for developing novel efficient antitumor drugs, and the 2-aminopyrimidine compounds have important scientific significance and clinical transformation potential. # imgabs0 #

The preparation method comprises the following steps: taking para aminobenzoic acid, 3, 3-diaminobiphenyl and phosphorus pentoxide as raw materials, and carrying out high-temperature dehydration cyclization reaction in a polyphosphoric acid solvent to obtain a diamine monomer containing biimidazole; the preparation method comprises the following steps: adding a bis-imidazole-containing diamine monomer, 2-(4-aminophenyl)-5-aminobenzoxazole and an organic solvent into a reactor, stirring and dissolving, after the solution is clarified, adding pyromellitic dianhydride, stirring and reacting, and after the reaction is completed, obtaining a polyamide acid membrane casting solution; and carrying out film casting on the polyamide acid film casting solution, drying at low temperature, and transferring to a muffle furnace to carry out imidization reaction after solvent volatilization is finished, so as to obtain the bis-imidazole polyimide film. The biimidazole polyimide film constructed by the invention is applied to a flexible OLED substrate, and has relatively good thermal performance and mechanical performance.

Compositions and methods for the treatment of tuberculosis, as well as other mycobacterial and gram positive bacterial infections are disclosed. These compositions contain a highly potent and selective oxazolidinone encapsulated with high efficiency to maximize dosing potential of low toxicity drugs, and are stable in the presence of plasma. The compositions are long circulating and retain their encapsulated drug while in the circulation following intravenous dosing to allow for efficient accumulation at the site of the bacterial or mycobacterial infection. The high doses that can be achieved when combined with the long circulating properties and highly stable retention of the drug allow for a reduced frequency of administration when compared to daily or twice daily administrations of other drugs typically utilized to treat these infections.

The invention relates to the field of biological medicine, in particular to a construction method of a novel marine source 4-hydroxybenzoxazole-2 (3H)-thioketone carrier based on a beta-cyclodextrin metal organic framework and application of the novel marine source 4-hydroxybenzoxazole-2 (3H)-thioketone carrier to antibacterial activity enhancement. According to the invention, the effect of 4-hydroxybenzoxazol-2 (3H)-thioketone (HBOT) on resisting escherichia coli and shigella flexneri is found. The result shows that the antibacterial diameter of the HBOT on shigella flexneri is 15.78 + / -0.67 mm, and the antibacterial diameter of the HBOT on escherichia coli is 10.81 + / -0.50 mm; the MIC of the free HBOT to shigella flexneri is 128 [mu] g / mL, and the MIC of the beta-CD-MOF loaded with the free HBOT is 64 [mu] g / mL, so that the beta-CD-MOF loaded with the free HBOT has the capability of enhancing the antibacterial performance.

The invention discloses an iron-loaded sulfonated carbon nitride heterogeneous catalyst as well as a preparation method and application thereof, and belongs to the field of heterogeneous catalysts. The iron-loaded sulfonated carbon nitride heterogeneous catalyst consists of monatomic Fe and a sulfonated graphite phase carbon nitride carrier, so that the prepared iron-loaded sulfonated carbon nitride heterogeneous catalyst can catalyze the reaction of benzoxazole and absolute ethyl alcohol, is high in catalytic efficiency, can catalyze the reaction of benzimidazole or benzothiazole and absolute ethyl alcohol, and is high in catalytic efficiency. Therefore, 2-(1-hydroxyethyl)-benzimidazole or 2-(1-hydroxyethyl)-benzothiazole is synthesized, and concentrated acid does not need to be used as a catalyst in the synthesis process. The sulfonation degree of the iron-loaded sulfonated carbon nitride heterogeneous catalyst can be regulated and controlled, the iron-loaded sulfonated carbon nitride heterogeneous catalyst can catalyze the construction of a directional C-C bond, and the iron-loaded sulfonated carbon nitride heterogeneous catalyst keeps stable in the reaction process and can be recycled for 5 times or more.

The invention discloses a ZIF-based catalytic ceramic membrane, a preparation method and application of the ZIF-based catalytic ceramic membrane in water treatment, and belongs to the technical field of environmental functional materials and membrane separation. According to the method, a bimetallic precursor solution and an organic ligand solution are adopted, ZIF crystals grow on a ceramic membrane in situ, and then the ZIF-based catalytic ceramic membrane with Co-Co metallic bond and Co-N coordination double active sites is prepared through high-temperature pyrolysis and acid pickling treatment. The prepared ZIF-based catalytic ceramic membrane has high porosity (the specific surface area is greater than or equal to 360 m < 2 > / g) and strong binding force, can stably operate for 3720 minutes or more in a continuous flow reaction, has a removal rate of up to 90% for electronic-enriched pollutants such as sulfamethoxazole and the like, and can resist water quality interference. The process is simple, active sites are controllable, and the method is suitable for high-efficiency low-consumption treatment of industrial wastewater.

The invention provides an oxazomycin high-yield engineering strain as well as a construction method and application thereof. The method for constructing the oxazomycin high-yield engineering strain comprises the following steps: driving high expression of a gene cluster by using a strong promoter in streptomyces longsheng, enhancing transcription of a key resistance gene module (ozmS-oxaA), and optimizing ribosome engineering of strain chassis cells and a culture medium. According to the invention, the rational synthetic biology and metabolic engineering technology is combined with the irrational ribosome engineering technology to gradually increase the yield of the streptomyces longsheng oxazomycin, and the established efficient biosynthesis system lays a foundation for further development of the oxazomycin.

The invention discloses a high-load monatomic catalyst as well as a preparation method and application thereof. The monatomic catalyst is an iron monatomic catalyst, and is characterized in that the mass loading proportion of Fe can be regulated and controlled within the range of 5.16-41.31 wt%, which exceeds all Fe monatomic catalysts reported at present, and overcomes the bottleneck of few metal active sites of the monatomic catalyst. The method has the advantages that a cascade anchoring strategy is adopted, and Fe < 3 + > is assembled into a macromolecular organic framework through the multifunctional effect of a chelating agent. And calcining the obtained precursor in N2 atmosphere at 550 DEG C for 4 hours to obtain the high-quality loaded iron monatomic catalyst. The preparation method is simple, low-cost and environment-friendly. The prepared monatomic catalyst with the high iron loading capacity has more active sites, the activation performance of potassium hydrogen persulfate is remarkably improved, the degradation kinetics of sulfamethoxazole (SMX) is improved, the SMX removal rate of 90% or above can still be kept after the catalyst is repeatedly used for five times, and it is indicated that the catalyst has good activity and durability.