5 results about "Immunomodulatory Agent" patented technology

Disclosed are combinations comprising a therapeutically effective amount of a menin-MLL inhibitor of Formula (I) or a pharmaceutically acceptable salt or a solvate thereof; and a therapeutically effective amount of at least one other therapeutic agent which is a hypomethylating agent, a cytidine deaminase inhibitor, a DNA intercalating agent, a pyrimidine analog, a purine analog, a kinase inhibitor, a CD20 inhibitor, an IDH inhibitor, an immunomodulatory agent or a DHODH inhibitor. Also disclosed are methods for treating a subject who has been diagnosed with cancer using such combinations. Compounds are represented by Formula (I) as follows:wherein the variables are defined herein.

Provided are methods for treating patients with type 1 diabetes, wherein the patient has new onset type 1 diabetes no more than eight months before starting treatment, and has not previously received an immunomodulatory agent. Also provided are methods for improving cell health in a patient having type 1 diabetes. Also provided are methods for preserving residual C-peptide in a patient having type 1 diabetes. The methods comprise administering an effective amount of a pharmaceutical therapy that comprises eflornithine while the patient is maintained on a low polyamine diet, wherein the method prevents, delays, decreases the likelihood of, or decreases the severity of diabetic ketoacidosis severe hypoglycemia, progression of diabetic nephropathy and retinopathy.

The invention discloses an immunomodulator based on cinnamon leaf processing byproducts and application thereof.The preparation method of cinnamon leaf extract comprises the following steps that S1, waste cinnamon leaves obtained after oil extraction are smashed into powder, water is added for soaking, and a soaking solution is obtained; s2, refluxing, heating and extracting the soaking solution, filtering to obtain filtrate, concentrating the filtrate, and centrifuging to obtain supernate; and S3, adding ethanol into the supernate until the volume percent of the ethanol is 75-90%, standing at the temperature of 1-5 DEG C for 8-16 hours, centrifuging, collecting precipitate, and freeze-drying to obtain the cinnamon leaf extract. According to the cinnamon leaf extract, waste cinnamon leaves obtained after essential oil is extracted serve as a raw material, the cinnamon leaf extract is obtained through the processes that soaking and reflux extraction are conducted, a solution with the specific alcohol content stands and precipitates at the low temperature, and precipitates are dried at the extremely low temperature, the cinnamon leaf polysaccharide serves as the main component of the cinnamon leaf extract, and the cinnamon leaf extract is free of cytotoxicity and has the immunoregulation effect; the product can be developed into an immunomodulator, a health care product and the like.

Compositions of recombinant intravenous immunoglobulin (rIVIG) proteins and methods for purifying and using rIVIG proteins. The compositions comprise oligomeric Fc molecules that bind Fc receptors with high avidity. The rIVIG proteins are useful as immunomodulatory molecules to treat immune disorders, including autoimmune diseases, such as refractory immune thrombocytopenia, chronic inflammatory demyelinating polyneuropathy, multiple sclerosis, lupus, Graves' disease, Kawasaki disease, dermatomyositis, myasthenia gravis, Guillain-Barre syndrome, autoimmune hemolytic anemia, and other immune and inflammatory conditions. The rIVIG proteins are also useful as immunomodulatory agents for patients to reduce immune rejection of organ transplants, stem cell transplants, and bone marrow transplants. In addition, the present invention provides rIVIG proteins of non-human origin for use in veterinary immune disorders, such as canine rIVIG proteins for treating dogs with autoimmune hemolytic anemia, immune thrombocytopenic purpura, rheumatoid arthritis, or other canine immune disorders.

This invention discloses a method for preparing sea cucumber exosomes with immune cell repair function and their application, belonging to the field of biomedical technology. This invention employs a combined method of compound stress and echinacea extract to feed sea cucumbers, extracting sea cucumber cells and obtaining sea cucumber exosomes through ultracentrifugation. The compound stress conditions are set as follows: a diurnal temperature difference of no less than 3 degrees Celsius, and the dissolved oxygen content of the water is adjusted to 75-90% of the dissolved oxygen content of conventional rearing water. The sea cucumber exosomes obtained by this invention possess significant immune cell repair function, effectively promoting the proliferation and recovery of immune cell activity, inhibiting the expression of inflammatory factors, and increasing the level of anti-inflammatory factors. The sea cucumber exosomes prepared by this method have important application prospects in the development of immune repair drugs and can provide technical support for novel immunomodulatory agents in the biomedical field.