650results about How to "Raise count" patented technology

Compositions, methods and kits are disclosed for high-sensitivity single molecule digital counting by the stochastic labeling of a collection of identical molecules by attachment of a diverse set of labels. Each copy of a molecule randomly chooses from a non-depleting reservoir of diverse labels. Detection may be by a variety of methods including hybridization based or sequencing. Molecules that would otherwise be identical in information content can be labeled to create a separately detectable product that is unique or approximately unique in a collection. This stochastic transformation relaxes the problem of counting molecules from one of locating and identifying identical molecules to a series of binary digital questions detecting whether preprogrammed labels are present. The methods may be used, for example, to estimate the number of separate molecules of a given type or types within a sample.

A digital imaging system and method using multiple cameras arranged and aligned to create a much larger virtual image sensor array. Each camera has a lens with an optical axis aligned parallel to the optical axes of the other camera lenses, and a digital image sensor array with one or more non-contiguous pixelated sensors. The non-contiguous sensor arrays are spatially arranged relative to their respective optical axes so that each sensor images a portion of a target region that is substantially different from other portions of the target region imaged by other sensors, and preferably overlaps adjacent portions imaged by the other sensors. In this manner, the portions imaged by one set of sensors completely fill the image gaps found between other portions imaged by other sets of sensors, so that a seamless mosaic image of the target region may be produced.

Embodiments of this invention provide methods, systems, and apparatus for determining whether a fetal chromosomal aneuploidy exists from a biological sample obtained from a pregnant female. Nucleic acid molecules of the biological sample are sequenced, such that a fraction of the genome is sequenced. Respective amounts of a clinically-relevant chromosome and of background chromosomes are determined from results of the sequencing. The determination of the relative amounts may count sequences of only certain length. A parameter derived from these amounts (e.g. a ratio) is compared to one or more cutoff values, thereby determining a classification of whether a fetal chromosomal aneuploidy exists. Prior to sequencing, the biological sample may be enriched for DNA fragments of a particular sizes.

A home agent management apparatus and method for routing a packet using a home network equipment as a home agent in a mobile Inter Protocol version 6 (IPv6) are provided. The home agent management apparatus includes a packet analyzer, which receives a packet and analyzes the packet; a database, which stores information indicating whether a home agent of a home network operates normally according to the result of the analysis; and a home agent function executor, which performs a home agent function in place of the home agent when the home agent does not operate normally. Accordingly, a load concentrated on a home agent of an Internet Service Provider (ISP) can be split.

A microcrystalline germanium image sensor array. The array includes a number of pixel circuits fabricated in or on a substrate. Each pixel circuit comprises a charge collecting electrode for collecting electrical charges and a readout means for reading out the charges collected by the charge collecting electrode. A photodiode layer of charge generating material located above the pixel circuits convert electromagnetic radiation into electrical charges. This photodiode layer includes microcrystalline germanium and defines at least an n-layer, and i-layer and a p-layer. The sensor array also includes and a surface electrode in the form of a grid or thin transparent layer located above the layer of charge generating material. The sensor is especially useful for imaging in visible and near infrared spectral regions of the electromagnetic spectrum and provides imaging with starlight illumination.

A method of making a lead frame and a partially patterned lead frame package with near-chip scale packaging lead-count, wherein the method lends itself to better automation of the manufacturing line and improved quality and reliability of the packages produced therefrom. A major portion of the manufacturing process steps is performed with a partially patterned strip of metal formed into a web-like lead frame on one side so that the web-like lead frame is also rigid mechanically and robust thermally to perform without distortion or deformation during the chip-attach and wire bond processes, both at the chip level and the package level. The bottom side of the metal lead frame is patterned to isolate the chip-pad and the wire bond contacts only after the front side, including the chip and wires, is hermetically sealed with an encapsulant. The resultant package being electrically isolated enables strip testing and reliable singulation.

This relates to an improved delivery system for accurately loading and controlling the delivery of flowable material to a patient. Particularly, the system may be used in the injection of hard tissue implant materials such as PMMA under pressures up to about 4000 psi. The system includes an applicator with a first column having an implant material introduction section adapted to provide for effective loading of the implant material and a second column housing a piston. The introduction section has a larger size than that of a vessel section or bore in which the requisite pressure seal between the piston and bore wall is formed. The first column may include an introduction section flared open to an included larger funnel-like opening or a separate funnel may be used that interfaces with the introduction section to facilitate the introduction of implant material. Handles on the first and second columns to be turned relative to each other to advance the columns toward each other may be provided for manual actuation of the applicator to drive implant material through a cannula and deliver implant material to a desired site.

The invention relates to a method and device for detecting and analyzing the reception behavior of people in at last one reception room according to visual, audiovisual and/or auditory messages, actions and/or to the guiding of flows of customers. The method should be able to be realized with a lower degree of complexity than that of prior art methods. The invention is characterized in that, from the moment each person enters the reception room until their departure, their location coordinates, body coordinates, turning movements and rotating movements of their body and/or of parts of their body, as well as the posture of their body and/or the position of their extremities are detected with a frequency that is greater than one.

A method and apparatus are described including determining a number of clips to be streamed, requesting a selection of a mesh cache server to meet quality of service requirements for streaming the determined number of clips, establishing a streaming route responsive to the mesh cache server selection, receiving the number of streamed clips from the selected mesh cache server if the request is granted, joining a peer-to-peer network, downloading a next clip via the peer-to-peer network, requesting a selection of a mesh cache server to meet quality of service requirements for complimentary streaming any data missing from the next clip, receiving any data missing from the next clip via complimentary streaming if the request for complimentary streaming is granted and continuing to download any missing data of the next clip that has at least one of not passed its playback deadline and not been requested via complimentary streaming.

A radial gap, transverse flux dynamoelectric machine comprises stator and rotor assemblies. The rotor assembly comprises at least two axially spaced, planar rotor layers having equal numbers of magnetic poles of alternating polarity disposed equiangularly about the rotor peripheral circumference. A magnetically permeable member optionally links adjacent rotor magnets. The stator assembly comprises a plurality of amorphous metal stator cores terminating in first and second polefaces. The cores are disposed equiangularly about the peripheral circumference of the stator assembly with their polefaces axially aligned. Respective first and second polefaces are in layers radially adjacent corresponding rotor layers. Stator windings encircle the stator cores. The device is operable at a high commutating frequency and may have a high pole count, providing high efficiency, torque, and power density, along with flexibility of design, ease of manufacture, and efficient use of magnetic materials.

One embodiment of the invention is a semiconductor system (1400) of arrays (1401, 1402, etc.) of packaged devices. Each array includes a sheet-like substrate (1411, 1412, etc.) made of insulating material integral with conductive horizontal lines and vertical vias, and terminals on the surfaces. Semiconductor components, which may include more than one active or passive chips, or chips of different sizes, are attached to the substrate; the electrical connections may include flip-chip, wire bond, or combination techniques. Encapsulation compound (1412, 1422, etc.), which adheres to the substrate, embeds the connected components. Metal posts (1431, 1432, etc.) traverse the encapsulation compound vertically, connecting the substrate vias with pads on the encapsulation surface. The pads are covered with solder bodies used to connect to the next-level device array so that a 3-dimensional system of packaged devices is formed.

An implant for treating brain aneurysms, especially terminal aneurysms, comprises a neck cover and elongate shaft removably secured to an embolic delivery catheter. As such, the shaft aids in directing and placing the cover at the aneurysm neck, protecting the delivery catheter from adhesion with the embolic material, and securing the cover in place with connection or adhesion of the shaft to the embolic material delivered through the catheter. The implant can be anchored at the aneurysm either by interface and/or adhesion of the shaft or shaft and cover with the resident embolic materials.

Disclosed is a fiber-optic cable that possesses a high cable filling coefficient (and/or a high cable fiber density) yet ensures that its enclosed optical fibers demonstrate improved attenuation performance when subjected to temperature variations between about −40° C. and 70° C. The fiber-optic cable is suitable for efficient installation into ducts, such as via blowing.

Thrombopoietic compositions are provided comprising tyrosyl tRNA synthetase polypeptides, including truncations and/or variants thereof. Also provided are methods of using such compositions in the treatment of conditions that benefit from increased thrombopoiesis, such as thrombocytopenia.

A method and apparatus for controlling the phase and frequency of the local clock of a USB device, the apparatus comprising circuitry for observing USB traffic and decoding from the USB traffic a periodic data structure containing information about the frequency and phase of a distributed clock frequency, and phase and circuitry for receiving the periodic data structure and generating from at least the periodic data structure a local clock signal locked in both frequency and phase to the periodic data structure. The circuitry for receiving the periodic data structure and generating the local clock signal can generate the local clock signal with a frequency that is a non-integral multiple of a frequency of the periodic data structure.

A smoking article having one or more reconstituted tobacco split inner wrap strips is described. One or more split inner wrap strips extend coaxially along the tobacco column between the inner surface of an outer wrap of cigarette paper and the tobacco column. The tobacco blend includes burley and a second tobacco, such as flue-cured, oriental, Maryland, or rare and exotic tobaccos, and combinations thereof. This blend improves burley smoke character without increasing Hoffman analyte levels, especially tobacco-specific nitrosamines (i.e., TNSAs). A cigarette with an improved burley smoke character without increasing Hoffman analyte levels is also described.