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520 results about "Nanocarriers" patented technology

A nanocarrier is nanomaterial being used as a transport module for another substance, such as a drug. Commonly used nanocarriers include micelles, polymers, carbon-based materials, liposomes and other substances. Nanocarriers are currently being studied for their use in drug delivery and their unique characteristics demonstrate potential use in chemotherapy.

Preparation method and application of plant-derived extruded nano vesicles

The invention discloses a preparation method and application of plant-derived extruded nano-vesicles, and relates to the technical field of biological medicines. The preparation method of the plant-derived extruded nano-vesicles comprises the following steps: juicing cleaned plant roots, stems, leaves, flowers or fruits to obtain plant juice, and filtering with gauze to obtain first filtrate; centrifuging the first filtrate at a low speed of 300-6000 * g to obtain a second filtrate; performing 8,000-20,000 * g centrifugation on the second filtrate for 0.5-3 hours at the temperature of 0-5 DEG C, so as to obtain a first precipitate; adding the first precipitate into a buffer solution, carrying out ultrasonic treatment, diluting, and sequentially passing through a filter membrane with the pore diameter of 0.4-10 microns and a filter membrane with the pore diameter of 0.1-0.4 microns, so as to obtain a third filtrate; and centrifuging the third filtrate, taking the precipitate, and resuspending to obtain the extruded nano-vesicles. Experimental detection shows that the extruded vesicles are similar to natural vesicles in characteristics, but the yield is far higher than that of the natural vesicles, and the extruded vesicles can serve as nano-carriers to be applied to a foundation or clinic.
Owner:WUHAN UNIV

Multi-effect bionic liposome transdermal repair carrier as well as preparation and application thereof

The invention relates to a multi-effect bionic liposome transdermal repair carrier and a preparation method and application thereof.The multi-effect bionic liposome transdermal repair carrier comprises active ingredients and a nano-carrier, and the active ingredients comprise sialic acid, saccharomycetes / rice fermentation product filtrate, arginine / lysine polypeptide and vitamin E in the mass ratio of (1-10): (2-8): (0.1-1): (0.5-4); the nano-carrier is prepared from the following raw materials: phospholipid, an emulsifier, polyhydric alcohol and water. Compared with the prior art, the anti-aging, whitening and moisturizing composition has the advantages of enhancing skin moisturizing and anti-oxidation effects, promoting collagen synthesis and inhibiting tyrosinase to achieve remarkable anti-aging, whitening and moisturizing effects and the like.
Owner:MAGELINE BIOLOGY TECH CO LTD +1

Nanometer delivery device for gastric cancer targeted drug and use method of nanometer delivery device

The invention discloses a nanometer delivery device for a gastric cancer targeted drug and a use method of the nanometer delivery device, and belongs to the technical field of drug targeted delivery. The device comprises a molecular recognition and optimization module which is responsible for accurately recognizing a tumor cell specific molecular marker and providing personalized treatment strategy recommendation; the nano-carrier design module is used for designing multifunctional lipid-polymer hybrid nano-particles and carrying out surface targeting ligand modification; the intelligent drug loading module is used for improving the stability and controllability of drug loading based on a pH / temperature sensitive release mechanism and effectively reducing the toxic influence of non-targeted tissues; the molecular imaging and monitoring module integrates a nanoprobe imaging technology and a quantum dot tracing technology, constructs a treatment-imaging integrated system, realizes real-time dynamic monitoring of a treatment process, and provides instant feedback of a molecular level; and the risk assessment module is used for establishing a safety database and providing dynamic risk assessment of the treatment process through a biological safety assessment system and long-term tracking management.
Owner:SHAANXI CANCER HOSPITAL (SHAANXI INST OF CANCER PREVENTION & TREATMENT) (SHAANXI THIRD PEOPLES HOSPITAL)

RGD-click chemical cross-linked siRNA nano-carrier, preparation method thereof and application of nano-carrier in preparation of medicine for treating secondary thyroidism

The invention discloses an RGD-click chemical crosslinking siRNA nano-carrier, a preparation method thereof and application of the nano-carrier in preparation of a medicine for treating secondary thyroidism, and belongs to the technical field of medicines.The nano-carrier is RGD-PEG-PLys (N), and the preparation method of the nano-carrier comprises the steps of synthesis of PLys (ss-DBCO), synthesis of RGD-PEG-PLys (N) and the like. According to the application, the nano-carrier is used for preparing siRNA composite nanoparticles; vascular endothelial targeting (RGD), dynamic stability (click crosslinking) and microenvironment responsiveness (disulfide bond) are organically combined for the first time to achieve mutual synergistic interaction, and the effect ceiling of an existing material is broken through; according to the siRNA composite nanoparticle, the silence effect of the PTH gene as long as 70 days can be achieved through single intravenous injection, the PTH inhibition rate is larger than 85%, the siRNA accumulation amount in parathyroid gland tissue is remarkably increased through RGD targeting (8.6 times that of a non-targeting group), the liver and kidney distribution amount is reduced by 60%, and the system toxicity is controllable.
Owner:FUJIAN MEDICAL UNIV UNION HOSPITAL

Formulations and doses of pegylated uricase

Provided herein are methods and compositions and kits related to uricase compositions and / or compositions comprising synthetic nanocarriers comprising an immunosuppressant. Also provided herein are methods and compositions and kits for the treatment of subjects, including subjects with hyperuricemia, gout or a condition associated with gout, and for preventing gout flare.
Owner:CARTESIAN THERAPEUTICS INC

Pancreatic cancer immunotherapy using cationic lipid and polymer nanocarriers for co-delivery of KRAS neoantigens and sting and / or other immunomodulators to boost the cancer immunity cycle and treat liver metastasis

Drug delivery nanoparticle compositions and methods for the treatment of a cancer are provided that can be used individually or in combination. These compositions and methods include: (1) exogenous vaccination using neoantigens or tumor-associated antigens to potentiate an anti-tumor immune response; (2) nanoparticle-based drug delivery targeting the liver, aimed at reprogramming the hepatic immune environment to reduce or eliminate tumor antigen tolerance, thereby enhancing the immune system's ability to combat metastatic cancer; and (3) expansion of the liver metastasis treatment platform to target tumor-associated lymphoid structures, supporting the immune response at the primary tumor site. Any of these methods may be optionally combined with chemo-immunotherapy for enhanced efficacy.
Owner:RGT UNIV OF CALIFORNIA

Preparation method and application of cell membrane modified ultrasonic response type copper / ferroptosis activated nano-carrier

The invention discloses a preparation method of a cell membrane modified ultrasonic response type copper / ferroptosis activated nano-carrier. The nano-carrier is used for in-vivo and in-vitro treatment of ultrasonically activated tumors. The carrier is used as an ultrasonic activation type copper / iron death activator, and breast cancer cell membrane doped lipid is coated on the outer layer of a copper-iron bimetal organic framework to form nanoparticles with a core-shell structure. The biomimetic copper / ferroptosis activated nano-carrier disclosed by the invention is mainly characterized in that (1) the in-vivo circulation time of the nano-carrier is prolonged by modification of a breast cancer cell membrane, and accumulation of the nano-carrier in breast cancer cells and tissues is improved by virtue of homologous targeting of the nano-carrier; (2) the copper-iron double-metal-doped metal organic framework has a uniform nano structure, and has the potential of effectively catalyzing Fenton / Fenton-like reaction activity and activating a copper / iron death synergistic effect in cells; and (3) depending on the sound-sensitive agent and the oxygen carrier which are loaded by lipid, the nano-carrier has an ultrasonic signal response release behavior, and can simultaneously activate a sonodynamic effect, a copper death process and an iron death process in tumor cells, so that accurate and efficient killing of tumor tissues is realized.
Owner:NANJING UNIV

Sea cucumber flower self-assembled polypeptide-iron nano-carrier as well as preparation method and application thereof

The invention belongs to the technical field of preparation of biological materials, and particularly discloses a sea cucumber flower self-assembled polypeptide-iron nano-carrier as well as a preparation method and application of the sea cucumber flower self-assembled polypeptide-iron nano-carrier. The preparation method comprises the following steps: dissolving freeze-dried sea cucumber flower powder in deionized water, adjusting the pH value to be alkaline, heating and stirring, centrifuging, discarding the precipitate, adjusting the pH value to be acidic, centrifuging, collecting the precipitate, and freeze-drying to obtain sea cucumber flower protein powder; preparing a reaction solution, adding simulated gastric juice and simulated intestinal juice, stirring for reaction, inactivating protease, centrifuging, taking supernatant, and freeze-drying to obtain sea cucumber flower self-assembled polypeptide; the preparation method comprises the following steps: preparing a solution from sea cucumber, adding FeCl2. 4H2O and ascorbic acid, adjusting the pH value to be acidic, carrying out heating reaction, centrifuging, discarding the supernatant, and freeze-drying to obtain the sea cucumber flower self-assembled polypeptide-iron nano-carrier. The invention discloses a sea cucumber flower self-assembled polypeptide-iron nano-carrier as well as a preparation method and application thereof. The carrier can promote absorption of an organism to iron, a relatively high iron ion release rate is maintained in an intestinal environment, and the in-vivo bioavailability of iron ions is improved.
Owner:ZHEJIANG UNIV OF TECH +1

Casein-based nano-carrier with slow release and pH / NIR dual response as well as preparation method and application of casein-based nano-carrier

The invention belongs to the technical field of nano-carriers, and particularly relates to a casein-based nano-carrier with slow release and pH / NIR dual response as well as a preparation method and application thereof, casein is combined with hollow copper sulfide nano-particles to load drugs, the nano-carrier with slow release and pH / NIR dual response is generated, and the drug loading rate is as high as 96.84%. Experiments show that the nano-carrier can accurately control drug release under specific pH and near-infrared light irradiation, so that the drug treatment efficiency is improved, and side effects on normal tissues are reduced.
Owner:ZHENGZHOU UNIV

DsRNA nanocrystallization preparation for preventing and treating areca yellows as well as preparation method and application of dsRNA nanocrystallization preparation

The invention relates to the technical field of agricultural biology, and particularly provides a dsRNA nanocrystallization preparation for preventing and treating areca yellows as well as a preparation method and application of the dsRNA nanocrystallization preparation. Areca yellows are a destructive disease caused by areca symptomless virus type 1 (APV1), eight key target gene segments of an APV1 virus genome are screened, specific double-stranded RNA is designed, a nano-carrier is used for wrapping and delivering a dsRNA mixture obtained by transcription of the eight target gene segments, and the areca yellows are obtained by screening. And a nanocrystallization preparation for improving the environmental stability and RNA interference efficiency of the dsRNA is prepared. Experimental results show that the nanocrystallization preparation can effectively inhibit the key gene expression of APV1 virus, reduce the virus load and improve the resistance of areca catechu to yellows. The invention provides an accurate, efficient and environment-friendly biological prevention and control strategy, and has a wide agricultural application prospect.
Owner:HAINAN UNIVERSITY SANYA NANFAN RESEARCH INSTITUTE

Sea cucumber flower self-assembled polypeptide-selenium nano-carrier with antioxidant activity as well as preparation method and application of sea cucumber flower self-assembled polypeptide-selenium nano-carrier

The invention discloses a sea cucumber flower self-assembled polypeptide-selenium nano-carrier with antioxidant activity and a preparation method and application thereof, belongs to the technical field of functional protein peptides, and particularly relates to a preparation method of the sea cucumber flower self-assembled polypeptide-selenium nano-carrier with antioxidant activity, which comprises the following steps: heating a sea cucumber flower protein solution; the preparation method comprises the following steps: mixing sea cucumber with simulated gastric juice, reacting for 30-150 minutes, then adding simulated intestinal juice, reacting for 20-120 minutes, carrying out enzyme deactivation treatment, centrifuging, taking supernate, and freeze-drying to obtain sea cucumber flower self-assembled polypeptide; and mixing the sea cucumber flower self-assembled polypeptide with deionized water to prepare a sea cucumber flower self-assembled polypeptide solution, mixing the sea cucumber flower self-assembled polypeptide solution with a sodium selenite solution and a phosphate buffer solution, reacting for 20-60 minutes, washing with an ethanol solution, centrifugally collecting precipitate, and freeze-drying to obtain the sea cucumber flower self-assembled polypeptide-selenium nano-carrier. The sea cucumber flower self-assembled polypeptide-selenium nano-carrier prepared by the invention has good antioxidant activity and potential of effectively delivering selenium to an organism.
Owner:ZHEJIANG UNIV OF TECH +1

Brown planthopper gene NlCYP303A1 and nano nucleic acid pesticide thereof

The invention discloses a brown planthopper gene NlCYP303A1 and a nano nucleic acid pesticide of the brown planthopper gene NlCYP303A1. The nucleotide sequence of the gene NlCYP303A1 disclosed by the invention is as shown in SEQ ID NO: 1; the nano nucleic acid pesticide is mainly prepared from zinc nitrate hexahydrate, dsN1CYP303A1 and 2-methylimidazole. The gene NlCYP303A1 closely related to the ecdysis process of the brown planthopper is identified, and silencing of the gene can cause ecdysis failure of the brown planthopper and reduce the survival rate of the brown planthopper; furthermore, a dsN1CYP303A1-coated ZIF-8 nano nucleic acid pesticide delivery system is constructed on the basis of a nano carrier ZIF-8, and the biological activity of the dsN1CYP303A1-coated ZIF-8 nano nucleic acid pesticide delivery system is measured; results show that the nano nucleic acid pesticide delivery system overcomes the defect that the service life of dsRNA is short, and the control effect of the nano nucleic acid pesticide delivery system on brown planthopper is remarkably improved. The potential application value of RNAi in pest control is improved, and a new strategy is provided for pest drug resistance treatment.
Owner:HUAZHONG AGRI UNIV

Personalized tumor vaccine based on hydrogel as well as preparation method and application thereof

The invention belongs to the technical field of tumor vaccines, and discloses a personalized tumor vaccine based on hydrogel and a preparation method and application thereof, the preparation method comprises the following steps: adding a chemotherapeutic drug into a mixed solution of polyphenol and metal ions, uniformly mixing, adjusting the pH value of the solution, and reacting for 2-8 hours to obtain a metal polyphenol nano-carrier loaded with the chemotherapeutic drug; co-culturing the obtained metal polyphenol nano-carrier loaded with the chemotherapeutic drug and tumor cells for 12-48 hours, and inducing the tumor cells to generate immunogenic cell death, wherein the concentration of the metal polyphenol nano-carrier loaded with the chemotherapeutic drug is 1-20 [mu] g / mL; the tumor cell suspension in the ICD state and the STING agonist solution are mixed with the sodium alginate solution, and the personalized tumor vaccine is obtained. The ICD is induced in vitro by the chemotherapeutic drug, so that the toxic and side effects of systemic administration are reduced, the types of antigens are enriched, and a powerful guarantee is provided for the vaccine to activate a strong in-vivo anti-tumor immune response.
Owner:SHANDONG UNIV

Targeted nanocarriers for systemic delivery of IRAK4 inhibitors to inflamed tissues

A nanoparticle for delivering an interleukin-1 receptor-associated kinase 4 (IRAK4) inhibitor to a subject and methods for treating inflamed tissue in a subject using the nanoparticle.
Owner:OREGON HEALTH & SCI UNIV +1

Polyethyleneimine low-toxicity nano-carrier capable of being used for delivering DNA molecules as well as preparation method and application of polyethyleneimine low-toxicity nano-carrier

The invention discloses a polyethyleneimine low-toxicity nano-carrier capable of being used for delivering DNA (deoxyribonucleic acid) molecules as well as a preparation method and application of the polyethyleneimine low-toxicity nano-carrier, and the polyethyleneimine low-toxicity nano-carrier can be used for accurately controlling surface charges and particle sizes of PEI nano-particles by adjusting parameters such as molecular weight, N / P ratio and the like of PEI, so that an ideal delivery effect is achieved, components and structures of a compound are reasonably designed, and gene delivery performance is optimized; a safe, efficient and reusable DNA delivery solution is provided for the fields of scientific research and medical treatment, and the method is of great significance in promoting gene therapy, vaccine development and other leading-edge scientific and technological progress.
Owner:ZHEJIANG UNIV OF TECH SHAOXING BIOMEDICAL RES INST CO LTD +1

Preparation method and application of nano protein

The invention provides a preparation method and application of nano protein, and the preparation method comprises the following steps: adopting lactoferrin as a carrier, reducing by using a reducing agent, stirring with DNA enzyme and a DNA chimeric agent, and obtaining the nano protein by using a nano precipitation method, the preparation method comprises the following steps: by taking lactoferrin as a nano-carrier, opening a folding structure of the lactoferrin by utilizing glutathione, then adding chloroquine and DNA enzyme, and finally, accelerating the reformation of a disulfide bond of the lactoferrin by stirring. On one hand, a DNA chimeric agent chloroquine is utilized to maintain the eDNA configuration in the biological membrane to be B type, and on the other hand, the mycobacterium tuberculosis biological membrane is efficiently disintegrated based on the enzymatic hydrolysis capability of DNA enzyme; the nano protein can efficiently grab iron ions at a focus part based on the iron chelation characteristic of the nano protein, so that bacteria die due to iron deficiency, and the bioavailability of DNA enzyme and the hydrolysis efficiency of a biological membrane can be improved to a great extent.
Owner:THE THIRD PEOPLES HOSPITAL OF SHENZHEN

Leonurine nanocomposite hydrogel and preparation methods and applications thereof

The present disclosure relates to a field of biomedical technology. Embodiments of the present disclosure provide a leonurine nanocomposite hydrogel and preparation method and application thereof, including: dissolving dopamine (DA) monomers and inducing oxidation and self-polymerization of the DA to obtain polydopamine (PDA) nanoparticles, grafting thiol polyethylene glycol folic acid (SH-PEG-FA) on a surface of the PDA nanoparticles to obtain folic acid polydopamine (FA-PDA) nanocarriers; loading a leonurine (Leon) using the FA-PDA nanocarriers of the step 1 to obtain FA-PDA@Leon; encapsulating the FA-PDA@Leon of the step 2 into a gel matrix to obtain gel@FA-PDA@Leon hydrogel.
Owner:WEST CHINA HOSPITAL SICHUAN UNIV

A scalp care solution containing probiotic fermentation products and preparation method thereof

The invention discloses a scalp care solution containing a probiotic fermentation product and a preparation method thereof, which comprises the following raw materials by weight: 87-91 parts of water, 3-5 parts of glycerol, 4-9.3 parts of probiotic fermentation products, 1.3-2.6 parts of plant extracts, 0.4-0.8 parts of 1,2-hexanediol, 0.4-0.8 parts of p-hydroxyacetophenone, 0.1-0.3 parts of carbomer, 0.1-0.2 parts of arginine, 0.1-0.15 parts of trace components, and 7-11 parts of composite nano-carrier liquid. The scalp care solution provides nutrition for scalp probiotics by adding prebiotic fermentation products, such as lactobacillus fermentation products, bifid yeast fermentation product filtrate, altermonas fermentation product extract, and bifid yeast fermentation product lysate, which is beneficial to promoting the growth of scalp probiotics and enhancing the scalp barrier, thereby achieving scalp health.
Owner:YIWU XIYAN COSMETICS CO LTD

Pharmaceutical preparation of carbohydrates for therapeutic use

InactiveUS20250186345A1Organic active ingredientsLiposomal deliveryGolgi componentNanocarriers
The disclosure provides methods for preparation of carbohydrate replacement therapies (CRT) that include nanocarriers of carbohydrates and glycolipids for pharmaceutical delivery to cell interior, endoplasmic reticulum, and Golgi for treating CDG type I and CDG type II diseases as well as other metabolic disorders.
Owner:GLYCOMINE INC

Atomic dispersed Pd-Pt catalyst for dinitrotoluene hydrogenation reaction and preparation method and application thereof

The invention discloses an atomically dispersed Pd-Pt catalyst for dinitrotoluene hydrogenation reaction and its preparation method and application, and belongs to the technical field of organic chemical raw material synthesis. The catalyst is loaded on the surface of a nanocarrier in the form of a Pd-Pt atomically dispersed cluster by a coprecipitation method to obtain the atomically dispersed Pd-Pt catalyst. The loading amount of Pd in ​​the catalyst is 0.1-2.0wt%, and the content of Pt is 0.1-2.0wt%. The present invention utilizes atomic dispersion and Pd-Pt synergistic effects to enhance catalytic activity, effectively reducing catalyst costs. The catalyst of the present invention has strong hydrogenation activity and selectivity, and is very suitable for the application of catalyzing dinitrotoluene hydrogenation to prepare toluenediamine under mild conditions (20-60°C, 0.2-1.0MPa). The catalyst has low raw material cost, simple preparation process, stable performance and high catalytic activity.
Owner:INST OF METAL RESEARCH - CHINESE ACAD OF SCI

Insecticide delivery by nanocarriers

PCT designated stage expiredWO2025117659A1BiocideAnimal repellantsNanocarriersCyclodextrin
The disclosure relates to cyclodextrin-modified nanomaterials for carrying insecticides that release such insecticides under controlled conditions.
Owner:BASF CORPORATON +1

Traditional Chinese medicine composition for relieving acute kidney injury and preparation method thereof

The invention relates to the technical field of traditional Chinese medicine compositions, in particular to a traditional Chinese medicine composition for relieving acute kidney injury and a preparation method thereof.The traditional Chinese medicine composition comprises honeysuckle-derived exosome-like nano-vesicles (HELNVs), and the particle size distribution of the HELNVs is 68.06-164.20 nm. Firstly, the HELNVs retain various bioactive components of honeysuckle, and the HELNVs retain various bioactive components of the honeysuckle; the components can play a stronger pharmacological role through a synergistic effect; secondly, due to the nanoscale particle size (68.06-164.20 nm), the HELNVs can better penetrate through a biological barrier, and the targeting property and the bioavailability are improved; thirdly, the natural source and exosome-like structure of the HELNVs may endow the HELNVs with unique cell affinity, which is beneficial to the interaction of the HELNVs with target cells; finally, the HELNVs are used as a natural nano-carrier, so that the HELNVs have better safety.
Owner:ZHEJIANG UNIV OF TECH

A water-soluble thionaphthalimide photosensitizer, a preparation method thereof and an application thereof

The present invention discloses a water-soluble thionaphthalimide photosensitizer, a preparation method thereof and an application thereof, belonging to the field of organic optofunctional materials. The photosensitizer of the present invention uses thionaphthalimide containing an electron-donating effect as a parent body, and at the same time introduces a water-soluble polyethylene glycol (PEG) group at its amide position. In an aqueous solution, the photosensitizer can self-assemble into nanoparticles with a particle size of 147 nm without other nanocarriers, and has good absorption at 570 nm. The method of the present invention has the advantages of easily available raw materials, simple synthesis and easy separation. The prepared photosensitizer has good reactive oxygen generation ability under white light irradiation, good water solubility, and good photo, thermal and chemical stability. The ultraviolet-visible absorption tail peak can reach the near-infrared region. The nanoparticles have good photodynamic killing effect on cancer cells.
Owner:NANCHANG UNIV

Boletus concentrated powder composition lipid carrier with anti-aging effect as well as preparation method and application of boletus concentrated powder composition lipid carrier

The invention provides a bolete concentrated powder composition lipid carrier with an anti-aging effect as well as a preparation method and application of the bolete concentrated powder composition lipid carrier. The lipid carrier is prepared from the following substances in percentage by mass: 10 to 40 percent of bolete extract, 0.2 to 0.8 percent of antioxidant, 45 to 66 percent of solid lipid, 10 to 16 percent of liquid lipid and 4.2 to 7.8 percent of surfactant. According to the bolete concentrated powder composition lipid carrier provided by the invention, liquid lipid with anti-oxidation and light protection effects is mixed into solid lipid to construct a nano carrier matrix with a light protection function. Plant active ingredients with a light protection effect and an anti-oxidation effect and ergothioneine in the bolete extract are jointly loaded in a nano-structure lipid carrier, so that synergistic interaction of multiple effects is realized. The synergistic delivery system of the nanostructured lipid carrier can inhibit the photodegradation reaction of the ergothioneine and the generation of peculiar smell, improve the photostability of the ergothioneine, enhance the oxidation resistance of the ergothioneine in an acid environment, and improve the anti-aging effect.
Owner:XIAN NUOZHONGKANGJIAN BIOTECHNOLOGY CO LTD

Antifouling nanofiller and preparation method thereof

The invention provides an antifouling nanofiller and a preparation method thereof. The antifouling nano filler comprises the following raw materials: a nano carrier material and an antifouling bactericide, the antibacterial nano-carrier material is characterized in that the nano-carrier material comprises a nano-carrier material grafted with a natural organic compound, and the natural organic compound comprises at least one of a natural antibacterial alcohol or phenolic compound and a derivative thereof. The preparation method of the antifouling nano filler comprises the following steps: purifying the nano carrier material; modifying the purified nano carrier material; grafting the modified purified nano-carrier material with a natural organic compound; loading an antifouling bactericide on the obtained product to prepare an antifouling nano filler; wherein the natural organic compound comprises at least one of natural antibacterial alcohol or phenolic compounds and derivatives thereof. The antifouling nanofiller prepared by adopting the method disclosed by the invention has a good intelligent response effect, and the antifouling effect of the loaded antifouling agent is improved.
Owner:JIMEI UNIV

Scale up synthesis of silicasome nanocarriers

In order to facilitate the approval and commercialization of silicasome drug delivery systems (e.g. irinotecan silicasomes) it is necessary to scale up synthesis of the drug-loaded silicasomes. In this regard, it was discovered that the synthesis protocols used for laboratory synthesis of drug-loaded silicasomes (e.g., 500 mg / batch) do not scale to large scale silicasome production, because the resulting products were too heterogeneous for use as pharmaceuticals. Accordingly, new methods are provided herein that effectively afford the large-scale production of mesoporous silica nanoparticles (MSNPs) and lipid bilayer coated MSNPs (silicasomes).
Owner:RGT UNIV OF CALIFORNIA

Zirconium-iron bimetallic nano material, preparation method and application of zirconium-iron bimetallic nano material in preparation of medicine for treating breast cancer

The invention belongs to the technical field of biological medicines, and particularly relates to a ferrozirconium bimetallic nano-material, a preparation method and application of the ferrozirconium bimetallic nano-material in preparation of medicines for treating breast cancer. The ferrozirconium bimetallic nano material is formed by loading a CDK4 / 6 inhibitor on a nano carrier; wherein the nano carrier is an organic framework material Zr-Fe MOF containing double metals of Zr and Fe, and the CDK4 / 6 inhibitor is preferably ribociclib. A product ZFRH for treating breast cancer is obtained based on coupling of the ferrozirconium bimetallic nano-material provided by the invention with a targeted drug such as trastuzumab. The ZFRH provides a new method for developing a nano platform with an antibody function, and realizes a treatment strategy of combined anti-tumor of trastuzumab and a CDK4 / 6 inhibitor. As a safe and effective tumor treatment strategy, the ZFRH has huge clinical transformation potential.
Owner:AIR FORCE MEDICAL CENT PLA

Nano-composite photosensitizer for cross-epithelial iontophoresis corneal collagen cross-linking technology as well as preparation method and application of nano-composite photosensitizer

The invention relates to a nano composite photosensitizer for transepithelial iontophoresis corneal collagen crosslinking and a preparation method and application of the nano composite photosensitizer, and the prepared nitrogen-sulfur co-doped graphene quantum dot has the characteristics of small particle size, negative potential, high electron transfer efficiency, high optical excitation ROS efficiency and the like, is an excellent nano carrier of riboflavin sodium phosphate, and can be used for preparing the nano composite photosensitizer. The nano composite photosensitizer prepared by modifying riboflavin with nitrogen and sulfur co-doped graphene quantum dots has high electric field responsiveness, high corneal riboflavin infiltration capacity, high ROS generation efficiency and good biocompatibility; according to the invention, nitrogen-sulfur co-doped graphene quantum dots are synthesized by a simple hydrothermal method, and then the nitrogen-sulfur co-doped graphene quantum dot modified riboflavin nano-composite photosensitizer is synthesized by a one-step esterification reaction. The method is simple, environment-friendly and safe to operate, low in cost and beneficial to industrialization and entering a clinical test stage; according to the invention, the nano-composite photosensitizer of riboflavin modified by nitrogen and sulfur co-doped graphene quantum dots is creatively applied to a cross-epithelial iontophoresis cornea collagen cross-linking technique. By using the composite photosensitizer, the matrix riboflavin content similar to that of an epithelium-removed standard group can be realized; the biomechanical property slightly better than that of a gold standard group is realized; and compared with a gold standard operation, the advantages of epithelium retention and short penetration time are realized. The research result certainly provides a new insight for treatment in the field of keratoconus.
Owner:THE EYE HOSPITAL OF WENZHOU MEDICAL UNIVERSITY

Nitrogen-doped cellulose-based carbon nano carrier material as well as preparation method and application thereof

The invention belongs to the technical field of nano material energy storage, and provides a nitrogen-doped cellulose-based carbon nano carrier material and a preparation method and application thereof, and the preparation method comprises the following steps: (1) pretreating nano cellulose sol to obtain a uniformly distributed nano cellulose solution; (2) freezing the nanocellulose solution, and performing vacuum drying to obtain nanocellulose aerogel; (3) carrying out pre-carbonization treatment on the nanocellulose aerogel in an inert atmosphere, and cooling to obtain nanocellulose carbon aerogel; and (4) placing the nanocellulose carbon aerogel in urea powder, and carrying out high-temperature vapor deposition in an inert atmosphere to obtain the nitrogen-doped nanocellulose-based carbon nano-carrier material. According to the nitrogen-doped cellulose-based carbon nano-carrier material, the selected raw material of the carbon nano-carrier material is plant fiber, the carbon nano-carrier material has very high mechanical strength, wide sources and low cost, and the prepared nitrogen-doped cellulose-based carbon nano-carrier material has good surface wettability and excellent conductivity and stability.
Owner:CENTRAL SOUTH UNIVERSITY OF FORESTRY AND TECHNOLOGY