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2 results about "Repolarization" patented technology
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In neuroscience, repolarization refers to the change in membrane potential that returns it to a negative value just after the depolarization phase of an action potential which has changed the membrane potential to a positive value. The repolarization phase usually returns the membrane potential back to the resting membrane potential. The efflux of K⁺ ions results in the falling phase of an action potential. The ions pass through the selectivity filter of the K⁺ channel pore.
System and method for digital modeling of cardiac cell membrane electrophysiology
PCT designated stageWO2026110144A1Medical simulationComputational materials scienceCapacitanceCells heart
A computational system and method for digital modeling of cardiac cell membrane electrophysiology is disclosed. The system generates a digital model representing the cell membrane as a dielectric lipid bilayer comprising a capacitor element and a resistor element, where the resistor element is emulated by a plurality of ion channels. The system calculates cell membrane potential based on intracellular and extracellular concentrations of key ions, such as Na+, K+, Ca2+, and Cl-, using the Goldman-Hodgkin-Katz equation. Generation of cellular membrane action potentials is simulated by modeling the opening and closing of voltage-gated ion channels in response to triggering events. The model provides dynamic visualizations of the distinct phases of the action potential, including depolarization and repolarization, offering a high-fidelity tool for research and for enhancing the realism of training simulations in electrophysiology procedures.
Owner:AIBODY IO LTD +1
Information processing device, operation method for information processing device, and operation program for information processing device
PCT designated stageWO2025204132A1Bioreactor/fermenter combinationsBiological substance pretreatmentsComputer hardwareInformation processing
This information processing device is provided with a processor. The processor acquires second-order differential data by subjecting waveform data, which indicate the change in extracellular potentials in accordance with the pulsation of cardiomyocytes, to second-order differentiation, detects a repolarization time at an action potential of the cardiomyocytes on the basis of the second-order differential data, and presents the results of the detection.
Owner:FUJIFILM CORP