50 results about "Repolarization" patented technology

A biologic intervention method and apparatus generates a persistent modification to an AV node that is physiologically stable after the agent has matured but is alterable with subsequent application of an agent. Specifically, the generic agent is used to modulate a node in a cardiac conduction system including rate control using one and a combination of a family of K+ channel or equivalent. Specifically, the channel is implemented to slow conduction by generating an outward current during optimization of action potential and repolarization phase thus decreasing the current that is available to excite downstream cells. A Kv 1.3 channel, for example, may be used as the biologic channel. The invention enables reversal of the modulation or adjustment for various heart rates (BPM) based on medical and patient-specific needs.

A system for heart performance characterization and abnormality detection processes a heart electrical activity signal in determining multiple first signal characteristic values over multiple heart cycles. A first signal characteristic value substantially comprises a time interval between a peak of a P wave to a peak of a succeeding R wave representing a repolarization time interval in an individual heart cycle and the signal processor uses a peak detector and time detector for identifying the peaks and detecting a time difference between the identified peaks. A comparator compares at least one of the multiple first signal characteristic values or a value derived from the multiple first signal characteristic values with a threshold value to provide a comparison indicator. A patient monitor in response to the comparison indicator indicating a calculated signal characteristic value exceeds the threshold value, generates an alert message associated with the threshold.

Methods and systems are provided for determining pacing parameters for an implantable medical device (IMD). The methods and systems provide electrodes in the right atrium (RA), right ventricle (RV) and left ventricle (LV). The methods and systems sense RV cardiac signals and LV cardiac signals at an RV electrode and an LV electrode, respectively, over multiple cardiac cycles, to collect global activation information. The methods and systems identify a T-wave in the LV cardiac signal. The methods and systems calculate a repolarization index based at least in part on a timing of the T-wave identified in the LV cardiac signal. The methods and systems set at least one pacing parameter based on the repolarization index, wherein the at least one pacing parameter that is set represents at least one of an AV delay, an inter-ventricular interval and an intra-ventricular interval. Optionally, the methods and systems may deliver an RV pacing stimulus at the RV electrode such that the LV cardiac signal sensed thereafter includes the RV pacing stimulus followed by a T-wave. The methods and systems determine a waveform metric such as at least one of a QT interval, T-wave duration, and T-wave amplitude, and utilize the waveform metric to determine as the repolarization index.

Nonlinear-dynamical control, also known as chaos control, can modulate human cardiac electrophysiological dynamics by stabilizing an unstable target rhythm. Intracardiac, repolarization alternans detection methods are disclosed that operates on the basis of amplitude or repolarization duration detection. Also disclosed are control methods for stabilizing repolarization alternans.

A system and associated method is disclosed for determining whether signal is valid. The system comprises an electrode apparatus comprising a plurality of electrodes configured to be located proximate tissue of a patient. A display apparatus comprising a graphical user interface, wherein the graphical user interface is configured to present information to a user. A computing apparatus coupled to the electrode apparatus and display apparatus, wherein the computing apparatus is configured to determine whether a signal acquired from a channel associated with an electrode from the plurality of electrodes is valid and sufficiently strong by i) calculating a first derivative of the signal; ii) determining a minimum and maximum derivative from the first derivative; iii) determining whether signs of the minimum and maximum derivative are different; and in response to determining whether the signs of the minimum and maximum derivative are different, displaying on a display apparatus whether the signal is valid.

The present invention provides compositions and methods of treatment for atrial fibrillation and ventricular tachycardia. The compositions are useful for modifying the conducting properties of heart tissues in which impulses are generating and / or are useful for altering refractoriness without prolonging repolarization.

An apparatus for detecting the bipolar HF wave of ventricle on the surface of body is composed of a movable unit consisting of signal acquisition circuit, amplifier, A / D converter and emitting module, and a fixed unit consisting of data receiver, USB communication unit, PC algorithm processing unit and output module. Its detecting method including signal conversion and removal of interference and noise is also disclosed.

A metering device for introducing liquid reducing agent into an exhaust gas pipe. A metering valve is supplied with contents from a working tank by a delivery unit and dispenses the tank contents in a discharge direction. The delivery unit establishes a negative pressure between the delivery unit and the metering valve when the delivery direction is reversed. The negative pressure causes gas to be drawn off through the metering valve against the discharge direction. The delivery direction is reversed by either a feed pump with a reversible effective direction or a feed pump and a repolarization valve which communicates with the feed pump and transposes an inlet and an outlet of the feed pump.

A device and method for cardiac rhythm management in which one heart chamber, designated as the synchronized chamber, is paced in accordance with a pacing mode that employs sense signals from the opposite chamber, designated as the rate chamber. A synchronized chamber protection period triggered by an intrinsic or paced beat in the synchronized chamber is used to inhibit pacing without otherwise disturbing the pacing algorithm. The duration of the synchronized chamber protection period is dynamically adjusted based upon detection of a repolarization in the synchronized chamber

The invention relate to a J wave extraction method, in particular to a blind source separation for extracting J wave signals in an electrocardiogram on the basis of a cyclostationarity standard. According to the method, a Givens rotation matrix serves as a separation matrix. The J wave signals are a new index of upper chamber repolarization of the electrocardiogram (ECG), and it is indicated in clinical data that shapes of the J wave signals in the ECG are different, randomness is high and the J wave signals are lost in the normal ECG and can not be observed sometimes. In order to accurately extract the J wave signals, according to the method, wavelet packet transform (WPT) is adopted in advance to analyze, reconstruct and position an ST section where J waves are located, and accordingly the calculation amount of blind source separation (BSS) is reduced; according to the characteristics of the ECG and the J wave signals, the ECG stable in circulation and the non-cycle J wave signals are effectively separated by means of the BSS method based on higher-order cyclic cumulant, and guarantees are provided for research of the J wave signals in a time domain in the next step and separation of the good state and the high-risk state.

The invention discloses insulation particles of a three-dimensional electrode reactor and preparation and application method thereof. The insulation particles are prepared by polyimide membrane coated particle electrodes with the same materials and the same shapes; and the insulation particles and the particle electrodes are uniformly mixed by mass or volume ratio of 25-35% to 65-75% as bed fillers of the three-dimensional electrode reactor for degrading organic waste water. The insulation particles prepared by the invention are resistant to acid and alkali, wear-resistant, good in insulation effect, long in service life, strong in adaptability and wide in range of application, and can solve the problem of delamination and insulation failure of the particle electrodes and quartz sands, glass balls, plastics and the like, overcome the defects that the acetyl cellulose membrane is low in strength, non-resistant to wear and corrode and easy to dissolve and drop, increase repolarization rate of the particle electrodes in the bed fillers, reduce short circuit current, improve current efficiency, lower electric consumption, and enhance degrading efficiency and treatment effect of the three-dimensional electrode reactor on the organic waste water.

A method of identifying and measuring altemans in an electrocardiographic (ECG) signal representative of the electric activity of a heart of a patient. The ECG signals from the patient are divided into individual cardiac cycles and the amplitude of four segments of the repolarization portion and the depolarization portion of each cardiac cycle are measured. The amplitude for each of the repolarization segments are measured from a reference baseline that is determined by a first base segment occurring immediately prior to the repolarization portion of the present cardiac cycle and a second base segment occurring immediately before the depolarization portion of the next cardiac cycle in the sequence. Based upon the amplitude measurements over the repolarization and the depolarization portions of each cardiac cycle, digital signal processing is applied to the measurements to generate eigenvariables. A spectral density is calculated for each of the eigenvariables, which spectral densities can be used to determine both the presence of altemans and the respiratory frequency.

The invention provides an apparatus and method for measuring the repolarization rate of a one-dimensional material. According to the method, the interference of left-(right-)rotated elliptically polarized light and scattered light of the one-dimensional material is used, and the contributions of the real parts (imaginary parts) of the repolarization rates in two groups of results are opposite (same), thereby quantitatively measuring the repolarization rate of the one-dimensional material. The device comprises a light source, a first polarizing film, a quarter wave plate, a first polarization maintaining lens, a sample of the one-dimensional material to be measured, a second polarization maintaining lens, a second polarizing film and a spectrometer. Alternatively, the apparatus includes a light source, a first polarizer, a quarter wave plate, a beam splitter, a polarization maintaining lens, a sample of the one-dimensional material to be tested, a second polarizing plate, a mirror, anda spectrometer. According to the invention, the measurement of the repolarization rate of the one-dimensional material is realized for the first time, and the device has the characteristics of high measurement speed, wide measurement frequency band (1.6 eV-2.7 eV), no damage to the sample to be measured, simple operation and easily available equipment.

This invention is directed to methods for controlling the duration of the depolarization and repolarization of the cardiac ventricle and therefore the QT interval, in therapeutically useful ways in a subject, comprising administering to the subject in need thereof a therapeutically effective amount of a compound selected from the group consisting of Formula (I) and Formula (II), or a pharmaceutically acceptable salt or ester thereof: wherein phenyl is substituted at X with one to five halogen atoms selected from the group consisting of fluorine, chlorine, bromine and iodine; and, R1, R2, R3, R4, R5 and R6 are independently selected from the group consisting of hydrogen and C1-C4 alkyl; wherein C1-C4 alkyl is optionally substituted with phenyl, wherein phenyl is optionally substituted with substituents independently selected from the group consisting of halogen, C1-C4 alkyl, C1-C4 alkoxy, amino, nitro and cyano.

The invention relates to an integrative method and device for treating wastewater with advanced oxidation. Treatment is performed in a reactor; the reactor is composed of an anode anaerobic microorganism reaction chamber and a cathode advanced oxidation reaction chamber; the anode anaerobic microorganism reaction chamber is internally provided with an anode electrode and is filled with a mixture of granular active carbon and anaerobic electricity generation bacteria; the cathode advanced oxidation reaction chamber is internally provided with multiple layers of cathode plates; the anode electrode is connected with the cathode plate at the uppermost layer through a wire; and a solid catalyst filler is filled between every two layers of the cathode plates at intervals. By adopting the integrative method and device provided by the invention, at normal temperature and normal pressure, strong oxidative radicals are produced under the catalytic action of a solid catalyst, electricity is generated by utilizing an integrative microbiological fuel cell, and repolarization electric field assistance is formed in the cathode advanced oxidation reaction chamber; the solid catalyst filler also acts as a particle electrode, the effects of repolarization electro-catalysis and catalytic wet oxidation are generated, and the removal rate of pollutants is improved; and by adopting a multi-stage cathode plate microporous aeration or hollow fiber membrane air supply manner, the oxidant utilization rate and the energy utilization rate are improved.

The invention discloses an electrocardiosignal processing method and device, a storage medium and a processor. The method includes the steps that a first electrocardiosignal in a first preset time period is obtained, wherein the first electrocardiosignal is used for characterizing electrocardiosignal changes between ventricle depolarization and repolarization; an offset sequence of the first electrocardiosignal is obtained, wherein multiple offset values contained in the offset sequence are used for characterizing changes of the first electrocardiosignal relative to reference voltage, and thereference voltage is extracted from an electrocardiosignal; the characteristics of the offset sequence of the first electrocardiosignal are extracted, and a characteristic vector is obtained, whereinthe characteristic vector comprises characteristics based on the poincare section, morphological characteristics and global characteristics; the characteristic vector is identified, and the offset type of the first electrocardiosignal is obtained. By means of the electrocardiosignal processing method and device, the storage medium and the processor, the technical problem that as a processing method for electric signals in an existing technical center is largely influenced by individual specificity and lead specificity, the processing efficiency is low is solved.

The invention which discloses a membrane polar distance repolarization natural cyclic ionic membrane electrolytic tank relates to an electrolytic device used in chlor-alkali industry and aims at solving the problem that the tank voltage is influenced by the solution voltage drop existing among the electrodes in the prior art. The invention mainly consists of unit electrolytic tanks (2), an end part semi-unit electrolytic tank and a sealing pad and ionic membranes (3) which are positioned between the unit electrolytic tanks; the invention has the design points that a support net (11) of a cathode side is welded on a cathode plate (9) to form a cathode chamber through a cathode side gluten plate (10); the cathode side of the unit electrolytic tank also comprises a cathode net (13) and an elastic net (12) which is welded on the support net of the cathode side while the cathode net is arranged outside the elastic net and a sealing surface of a frame is lapped and fixed around the cathode net; the ionic membranes of and among all unit electrolytic tanks are serially connected through a side rod (1) of an extruder and the cathode, the ionic membranes and the anode are closely connected. The ionic membrane electrolytic tank has the advantages of more stable running, great resistance to positive-negative pressure difference, low voltage and low electricity consumption.

Systems and methods are provided to detect subwaveforms of an ECG waveform. Electrical impulses are detected between at least one pair of electrodes of two or more electrodes placed proximate to a beating heart and are converted to an ECG waveform for each heartbeat of the beating heart using the detector. One or more subwaveforms within P, Q, R, S, T, U, and J waveforms of the ECG waveform for each heartbeat or in an interval between the P, Q, R, S, T, U, and J waveforms that represent the depolarization or repolarization of an anatomically distinct portion of muscle tissue of the beating heart are detected using a signal processor. A processed ECG waveform that includes the one or more subwaveforms for each heartbeat is produced using the signal processor. The processed ECG waveform is received from the signal processor is displayed using a display device.

A system for heart performance characterization and abnormality detection processes a heart electrical activity signal in determining multiple first signal characteristic values over multiple heart cycles. A first signal characteristic value substantially comprises a time interval between a peak of a P wave to a peak of a succeeding R wave representing a repolarization time interval in an individual heart cycle and the signal processor uses a peak detector and time detector for identifying the peaks and detecting a time difference between the identified peaks. A comparator compares at least one of the multiple first signal characteristic values or a value derived from the multiple first signal characteristic values with a threshold value to provide a comparison indicator. A patient monitor in response to the comparison indicator indicating a calculated signal characteristic value exceeds the threshold value, generates an alert message associated with the threshold.

A method using a prior art hand-held device known as the Dolphin Neurostim™ to supply minute, concentrated micro-current impulses to the (outside) perimeters of scar tissue for the purpose of tissue diagnosis (through ohm resistance measurement), promotion of scar tissue repair (through electrical repolarization), and pain management (through sympathetic deregulation of the Autonomic Nervous System. The micro-current stimulus (therapy) is delivered through a tiny metallic spring tip (probe) ideally suited for location (detection) of specific treatment points (which have the cellular characteristic and lowered skin resistance). The device is activated to deliver a concentrated (DC) micro-current stimulus through the scar / suture tissue to another identical device located (mirrored) on the opposing side of the scar / suture. This stimulation reactivates cellular metabolism and membrane exchange, changing scars appearance, softening scar / suture tissue by releasing relating adhesions which re-balances the autonomic nervous system.

A real-time detection technique and a real-time, adaptive, model-independent control technique for detecting and stabilizing pathological physiological rhythms, such as repolarization alternans, on the basis of the rate dependence of excitable tissue such as cardiac and neuronal tissue is presented. Unlike other control methods, which require a number of beats to locate the period-1 fixed point, the technique locates the period-1 fixed point almost instantaneously, rapidly eliminating any higher-period or aperiodic rhythms.

A method for repolarizing a piezoelectric actuator associated with an injector mounted on an internal combustion engine of a vehicle, the piezoelectric actuator having undergone initial polarization before the vehicle was used, includes with the engine stopped:applying a first polarization voltage to the terminals of the piezoelectric actuator during a first specified time interval of not less than ten minutes,stopping the application of the first polarization voltage during a second time interval, following the first time interval and at least equal to the latter,applying a second polarization voltage to the terminals of the piezoelectric actuator during a third specified time interval, following the second time interval,stopping the application of the second polarization voltage to the terminals of the piezoelectric actuator after the third time interval,the successive first, second and third time intervals defining a repolarization sequence of the piezoelectric actuator.

The invention relates to a method for repolarizing primary hepatocytes in vitro. The method is characterized by comprising the following steps of planting a primary hepatocyte suspension into a cell culture insert in a perfusion planting mode; meanwhile, applying a compact force to the primary hepatocytes for enabling cell density in a unit volume to reach over 90 percent; then performing perfusion culture by using a serum-free medium with a hepatocyte phenotype. According to the method disclosed by the invention, a primary mature hepatocyte population is planted in a compact mechanical planting mode, and the repolarization of the hepatocytes in structural and functional mechanics are both formed early at twelfth hour after planting, so that the repolarizing speed of an in vitro hepatocyte population in a three-dimensional environment is improved, and primary mature hepatocytes with an approximate physiological function phenotype are provided for liver tissue engineering.

A real-time detection technique and a real-time, adaptive, model-independent control technique for detecting and stabilizing pathological physiological rhythms, such as repolarization alternans, on the basis of the rate dependence of excitable tissue such as cardiac and neuronal tissue is presented. Unlike other control methods, which require a number of beats to locate the period-1 fixed point, the technique locates the period-1 fixed point almost instantaneously, rapidly eliminating any higher-period or aperiodic rhythms.

A system for rapolarizing transducers in an ultrasonic probe (1) includes a plurality of transducers (2) and electrodes (5,7). The system includes a voltage generator (54) configured to generate a predetermined voltage high enough to repolarize the transducers, a switch (53) configured to control a supply of the predetermined voltage to the electrodes, a connector (51) configured to connect the electrodes to the switch through a plurality of lands (21,23), the lands being provided sufficiently insulated from each other to prevent a dielectric breakdown between the lands while repolarizing the transducers, an interface (56) configured to provide an instruction, and a controller (55) configured to control the voltage generator. An ultrasound imaging apparatus that uses the repolarization system and an ultrasonic probe are also provided.

A system and method for 3D activation recovery interval (ARI) imaging is provided that may be used to determine the spatial pattern of cardiac activation and recovery by reconstructing ARI maps noninvasively. This may be used for patients suffering from premature ventricular contraction (PVC), for example. Recovery plays an important role in the susceptibility to cardiac arrhythmias. Given the inhomogeneous and dynamic nature of the recovery pattern, a 3D ARI imaging can provide important information guiding determination of the underlying arrhythmogenesis. Additionally, 3D ARI imaging has the advantage of being able to be extracted from multiple, simultaneously recorded electrograms and reflects the dynamics and spatial characteristics of repolarization.

The invention relates to a device for enhancing the medicine curative effect by an amplitude modulation electric field. The device comprises a power supply, a central control unit, a frequency modulation signal generating unit, an amplitude modulation unit, a power amplification unit, an output distribution unit, an insulation electrode and an insulation electrode positioning system, wherein under the control of the central control unit, the frequency modulation signal generating unit generates a required frequency signal; the required frequency signal is modulated by the amplitude modulation unit to generate a square wave form amplitude modulation signal; the square wave from amplitude modulation signal is amplified by the power amplification unit and is then allocated onto one than one pair of insulation electrodes by the output distribution unit, so that an amplitude modulation electric field with the continuous weakness serious sudden change is generated between more than one pair of insulation electrodes. The amplitude modulation electric field with the continuous weakness serious sudden change is applied onto cells; cell membrane generates depolarization and repolarization, so that the membrane permeability reversibility is improved; the quantity of the medicine passing through the cell membranes is increased; the curative effect is enhanced.

A method for repolarizing a piezoelectric actuator associated with an injector mounted on an internal combustion engine of a vehicle, the piezoelectric actuator having undergone initial polarization before the vehicle was used, includes with the engine stopped:applying a first polarization voltage to the terminals of the piezoelectric actuator during a first specified time interval of not less than ten minutes,stopping the application of the first polarization voltage during a second time interval, following the first time interval and at least equal to the latter,applying a second polarization voltage to the terminals of the piezoelectric actuator during a third specified time interval, following the second time interval,stopping the application of the second polarization voltage to the terminals of the piezoelectric actuator after the third time interval,the successive first, second and third time intervals defining a repolarization sequence of the piezoelectric actuator.

The invention provides an application of hexachlorophene in the preparation of a KCNQ agonist. In addition, the invention provides an application of the hexachlorophene in the preparation of a medicine serving as the KCNQ agonist. In the application, the KCNQ agonist can be a KCNQ1 agonist, a KCNQ1 / KCNE1 agonist, a KCNQ2 agonist or KCNQ2 / KCNQ3 agonist. The hexachlorophene has the effects of shortening the action potential duration and treating the arrhythmia by boosting KCNQ1 / KCNE1 electric currents and promoting the repolarization of the action potential of myocardial cells. The subtype potentiation proves that the hexachlorophene is capable of enhancing KCNQ and M electric currents and has the effects of adjusting the membrane potential level by boosting KCNQ2 electric currents and KCNQ2 / KCNQ3 hetero-oligomer electric currents and weakening the issuing frequency of the action potential; the application of the hexachlorophene in the preparation of medicines taking KCNQ as anti-epileptic targets is realized, and the anti-epileptic effect is achieved.

A biologic intervention method and apparatus generates a persistent modification to an AV node that is physiologically stable after the agent has matured but is alterable with subsequent application of an agent. Specifically, the generic agent is used to modulate a node in a cardiac conduction system including rate control using one and a combination of a family of K+ channel or equivalent. Specifically, the channel is implemented to slow conduction by generating an outward current during optimization of action potential and repolarization phase thus decreasing the current that is available to excite downstream cells. A Kv 1.3 channel, for example, may be used as the biologic channel. The invention enables reversal of the modulation or adjustment for various heart rates (BPM) based on medical and patient-specific needs.