38 results about "Scar tissue" patented technology

The invention discloses a structural bionic space-time coupled axon guidance-synchronous degradation type nerve implant as well as a preparation method and application thereof. According to the preparation method, after collagen and polyvinyl alcohol are compounded, freeze-drying is performed through a specific freeze-drying process to obtain the composite nerve implant with a bunchy multi-channel and porous structure, so that the defect that the degradation rate of a current application product is too high is overcome. The degradation rate required by the composite nerve implant is regulated and controlled according to the proportion of the composite materials, the composite materials which are rapidly degraded can be designed at the two ends of the composite nerve implant with the long length, and the composite materials which are slowly degraded can be designed at the middle part of the composite nerve implant with the long length, so that the mechanical performance required by nerve regeneration is supported. The obtained nerve implant not only is beneficial to preventing cicatrix tissues from entering, but also can be used as a topographic clue of nerve regeneration related cells to guide nerve regeneration, in addition, the degradation rate of the material is synchronous with the nerve regeneration process, and finally, the material is continuously degraded along with nerve regeneration and is replaced by new tissues.

The invention provides a method for three-dimensional visualization of heart scars, a control device and a storage medium, and belongs to the technical field of three-dimensional heart modeling and visual display. The method comprises the following steps: matching a heart structure obtained by segmenting a pre-trained nnU-Net and a binary tag graph corresponding to a scar tissue with a myocardial shape shown by the binary tag graph of the heart structure by using a standard myocardial grid model as a template; and fitting deformation parameters of a standard myocardial grid model by using a deep learning regression model, and applying the deformation parameters to a standard grid to complete grid deformation so as to fit individual myocardial morphology. The heart shape prior is effectively utilized based on the template deformation method, so that the reconstructed three-dimensional model has higher anatomical consistency and fineness. And superposing the fitted three-dimensional myocardial grid model and the reconstructed scar tissue grid under the same coordinate for registration and superposition to realize image three-dimensional transparent myocardial scar visualization so as to accurately restore a continuous three-dimensional scar surface.

The invention provides a real-time analysis method for energy distribution of an ultrasonic hemorrhoid therapeutic apparatus, which comprises the following steps of: defining a boundary region of an initial displacement distribution map by using a boundary region of recurrent internal hemorrhoid and scar tissue, and extracting differential mechanical response characteristics of the boundary region, identifying the position of a high strain set area of the differential mechanical response characteristics as a shear strain concentration area; analyzing a strain value of the position of the shear strain concentration area, and if the strain value exceeds a preset strain threshold value, analyzing sound beam path deviation caused by sound radiation force pulse refraction in the scar tissue through two-dimensional correlation to obtain focus offset; adjusting the displacement distribution diagram through the boundary of the energy deposition region, and extracting the mechanical property distribution of the boundary region to obtain the energy deposition distribution of the target hemorrhoid tissue; and through the energy deposition distribution of the target hemorrhoid tissue, optimizing sound beam deflection parameters, obtaining target sound beam control parameters, and determining an energy deposition area.

The microneedle transdermal drug delivery device comprises a base and a microneedle body, the microneedle body is conical and comprises a needle body and a needle tip, a hollow needle tube is arranged in the needle tip, the needle body is in threaded fit with the base, a needle body adjusting mechanism is arranged in the base, the end of a drug delivery tube is inserted into the needle body, one end of the drug delivery tube is connected with the needle body, and the other end of the drug delivery tube is connected with the needle tip. One end of the medicine feeding pipe is connected with the base, the other end of the medicine feeding pipe is opened and penetrates through the middle of the base, a threaded groove matched with a medicine bottle in a threaded mode is formed in the portion, on the outer side of the opening of the medicine feeding pipe, of the base, a medicine pump is arranged in the medicine feeding pipe, and a liquid level sensor is arranged at the portion, between the medicine feeding pipe and the threaded groove, of the base. According to the medicine feeding device, the medicine quantity is better controlled, medicine feeding is deeper, the needle body enables medicine to deeply and effectively penetrate into scar tissue, the electronic display screen is adopted to adjust and select the medicine feeding dosage by controlling the medicine pump, and a user can conveniently and accurately grasp the medicine feeding dosage through the electronic display screen.

In some examples, a tool for, e.g., creating a sub-sternal tunnel in a patient or other use, is described. The tool may include a handle and a tunneling shaft coupled to the handle. The tunneling shaft extends from a proximal end to a distal end, and at least a portion of the tunneling shaft extends in a curved orientation between the first end to the distal end. The distal end of the tunneling shaft includes a cutting tool having a sharp edge. The cutting tool is moveable from a recessed position in which the sharp edge of the cutting tool is recessed into the distal end of the tunneling shaft to a deployed position in which the sharp edge of the cutting tool extends beyond the distal end of the tunneling shaft in the deployed position, e.g., to cut pericardium, scar tissue, and / or connective tissue with the sharp edge.

The utility model discloses an indwelling injection treatment device, and relates to the technical field of medical instruments, the indwelling injection treatment device is used for keloid treatment, the indwelling injection treatment device comprises a shell, an injection device and a plurality of fixing bands, the shell is provided with a cavity with a bottom opening; the injection device is located in the cavity and comprises a liquid storage barrel and at least one indwelling needle, the liquid storage barrel is used for storing liquid medicine, the indwelling needle is communicated with the liquid storage barrel, the indwelling needle is arranged towards the opening of the shell, and the indwelling needle is used for being indwelled in scar tissue; the injection device is used for injecting liquid medicine into scar tissues; the fixing band is detachably connected with the shell, and the fixing band is used for fixing the shell on the scar tissue. The keloid injector aims at enabling a keloid patient to perform injection operation at home without going back and forth to a hospital for many times.

A method for treating cellulite on a patient's skin is provided. The method includes identifying at least one region of said patient's skin with cellulite. The method further includes generating at least one scar tissue in at least one tissue portion in said region of skin, thereby generating at least one septa-like scar tissue in said region of said patient's skin. The step of generating at least one septa-like scar tissue in said region of said patient's skin treats cellulite.

This invention provides a pH-responsive immunomodulatory microneedle patch, its preparation method, and its application, belonging to the field of biomedical materials technology. This invention incorporates Zif-8 nanoparticles loaded with ChABC into GelMA hydrogel to prepare a pH-responsive immunomodulatory microneedle patch (Z@C-MN). As the patch gradually degrades, the system can continuously release Zn in a pH-responsive manner. 2+ Z@C-MN, along with ChABC, promotes in situ repair of cerebral fibrosis (SCI) after injury. Z@C-MN induces macrophage polarization towards a pro-regenerative phenotype, thereby downregulating the inflammatory response, increasing neurite length, and promoting the differentiation of neural stem cells into neurons. In vivo, Z@C-MN reduced the inflammatory microenvironment after injury and promoted angiogenesis in a rat SCI model. Furthermore, it activated axonal regeneration by inhibiting scar tissue formation and regulating CD4+. + T cell transformation supports neurogenesis.

The present disclosure relates generally to the use of medical instruments for treating chronic venous disease and collagenous scar tissue. In particular, the present disclosure provides methods and systems for remodeling collagen obstructions using energy and expandable catheters.

The invention relates to a myocardial scar weak supervision segmentation method fusing a distance map and uncertainty, and belongs to the field of image segmentation. According to the method, the myocardial scar area is marked in a graffiti form, the marking cost is remarkably reduced, and the distance map is generated through graffiti and is used for constraining network prediction, so that the perception ability of the network to the scar boundary is improved; and meanwhile, an uncertainty estimation mechanism is introduced to further refine the segmentation result, and the scar tissue detection capability of the model under a weak supervision condition is enhanced. According to the method, the performance bottleneck existing when an existing weak supervision method processes category imbalance and boundary fuzziness is effectively solved, and the accuracy and robustness of myocardial scar segmentation are improved.

The invention discloses a human umbilical cord mesenchymal stem cell exosome for treating scars and a preparation method of the human umbilical cord mesenchymal stem cell exosome. The exosome is extracted from human umbilical cord mesenchymal stem cells pretreated by extracellular vesicles in scar tissues. The human umbilical cord mesenchymal stem cell exosome can be used for preparing medicines for improving and treating scars, has a potential action effect on early scar treatment, and has important significance on improving the scar treatment effect and improving the life quality of patients.

A portable knee bend exercise apparatus which allows for controlled use of the knee joint for exercise movements so as to reduce or prevent the buildup of scar tissue and to strengthen muscles around the joint. The portable knee bend exercise apparatus includes a wedge body having a support portion suitable to receive the thigh of a user, a lip portion suitable to provide an axis of rotation about which a knee can perform extension and flexion, a tapering portion which allows for full knee flexion, a bottom portion, and a back portion suitable to couple with a seat on which a user in seated. Coupled with the wedge body is a strap member which is structured to both encircle the wedge body and extend above the top surface to selectively form a loop which can secure the leg of a user to the top surface.

Electrical activity is sensed from a plurality of electrodes of a multi-electrode catheter. For each of a plurality of surface locations of cardiac tissue, the processor identifies a first electrical signal originating from a first depth and a second electrical signal originating from a second depth, estimating, for each of the first electrical signals, a first near-field signal originating from the first depth and detecting a scar boundary at the first depth based on the first near-field signal, and estimating, for each of the second electrical signals, a second near-field signal originating from the second depth and detecting a scar boundary at the second depth based on the second near-field signal. Based on the scar boundary detected at the first depth and the second depth, the processor visually displays first and second maps of the heart depicting scar tissue at the first and second depths, respectively.

The invention discloses recombinant collagenase as well as a preparation method and application thereof, and belongs to the technical field of biochemical engineering. The recombinant collagenase provided by the invention is prepared from HmCol and / or CbCol, the amino acid sequence of the HmCol is as shown in SEQ ID NO: 1; the amino acid sequence of the CbCol is as shown in SEQ ID NO: 2. Recombinant collagenase hydrolytic activity experiment results show that the expressed recombinant collagenase HmCol and CbCol can recognize recombinant collagen of different sources, including fragments of human III-type collagen recombined and expressed by escherichia coli, yeast and Chinese hamster ovary cells (CHO), so that the specificity and efficient hydrolysis of the collagen are realized, and the recombinant collagenase HmCol and CbCol can be used for identifying the recombinant collagen of different sources. The material has good application prospects in the aspects of scar tissue repair, low-temperature cold compress debridement and the like, and can be used as a raw material for preparing skin repair products.

The present disclosure relates to electroanatomical mapping of cardiac tissue at different depths using a multi-electrode catheter. A multi-electrode catheter within a patient's heart has a plurality of first electrodes on a first side adjacent to heart tissue at a first location and a plurality of second electrodes on a second side facing away from the heart tissue. Electrical activity is received from at least one electrode on the first side and at least one electrode on the second side, and a signal analysis is performed thereon based at least in part on a distance between electrodes on different sides of the multi-electrode catheter. The process is repeated for further locations of heart tissue in the heart and an electroanatomical map of the heart depicting electrical activity or scar tissue is generated based on the signal analysis.

The invention discloses a multifunctional targeting hydrogel based on chiral polypeptide as well as a preparation method and application thereof, and the multifunctional targeting hydrogel based on chiral polypeptide comprises the following raw materials in parts by weight: targeting nanoparticles loaded with a TGF-beta inhibitor, chiral antioxidant polypeptide, a cross-linking agent and water. The multifunctional targeted hydrogel has the functions of MI early-stage efficient ROS removal and MI late-stage targeted fibrosis blocking, has the functions of remodeling the infarction area microenvironment, inhibiting scar tissue expansion and recovering cardiac muscle synchronous electrical conduction, and finally achieves coordination of hydrogel degradation kinetics and the heart repair process and multi-dimensional repair of damaged cardiac muscle.

The invention provides a deep learning-based scalp health condition detection method and system, and relates to the technical field of image data processing, and the method comprises the steps: obtaining dermatoscope images and optical coherence tomography data of different scalp regions; constructing a voxel model with epidermis morphological characteristics and subcutaneous tissue scattering characteristics according to optical coherence tomography data; performing multi-layer convolution and pooling operation on the voxel model by using a pre-trained convolutional neural network to extract a high-dimensional feature vector; mapping the high-dimensional feature vector to a low-dimensional space by using a manifold learning algorithm, and calculating a target distance; on the basis of the target distance, the scalp area where the tissue type is the scar lesion type is marked as the irreversible alopecia area, so that detection of the scalp health condition is completed, subcutaneous hair follicle structure disappearance and fibrosis scar tissue are accurately distinguished under the non-invasive condition, and the detection accuracy is improved. The accuracy of scar alopecia judgment and the reliability of irreversible alopecia area recognition are improved.

A method for treating cellulite on a patient's skin includes identifying at least one region of said patient's skin with cellulite. The method includes generating at least one scar tissue in at least one tissue portion in said region of skin, thereby generating at least one septa-like scar tissue in said region of said patient's skin. The method further includes stabilizing said at least one septa-like scar tissue. Generating at least one septa-like scar tissue in said region of said patient's skin treats cellulite.

The utility model discloses a skin taking and grafting mobile phone with a graduated drill bit and an adjusting cap, and relates to the technical field of scar regeneration skin taking and grafting medical treatment. The skin taking and grafting mobile phone with the scale drill bit and the adjusting cap comprises a mobile phone rear cap and the scale drill bit, the outer wall of the mobile phone rear cap is in threaded connection with a motor sleeve, a rotating groove is formed in the outer wall of the motor sleeve, the outer wall of the motor sleeve is rotationally connected with a rotating cap, and the outer wall of the bottom end of the motor sleeve is in threaded connection with a mobile phone front cap; the bottom end of the mobile phone front cap is in threaded connection with an adjusting cap; a motor is fixedly connected in the motor sleeve, an output shaft of the motor is connected with a main shaft, one end of the main shaft is provided with a three-petal spring, and the three-petal spring clamps and fixes one end of the scale drill bit. A medical worker holds the shell of the skin taking and grafting mobile phone, a doctor evaluates the drilling depth according to the thickness of scar tissue of a patient so as to efficiently and conveniently adjust the depth of the scale bit, and due to the fact that laser-engraved scale marks are arranged on a tube body of the scale bit, the doctor can visually inspect the needle inserting depth, and accurate, efficient and precise treatment is achieved.

A surgical suturing device includes a suture needle configured to reliably pass through typically thick scar tissue present along, for example, the edge of a midline hernia. The surgical suturing device includes a first clamp and a second clamp. The suture needle is selectively supported on the first clamp or the second clamp at an acute angle, for example, relative to a longitudinal axis defined by the corresponding first clamp or second clamp. The suture needle can be selectively secured to the first clamp or the second clamp via a first needle-receiving leaflet and a second needle-receiving leaflet configured for reciprocating axial displacement. A suture thread is connected to the suture needle to perform tissue suturing.

Devices and methods for treatment of bodily lumens and sphincters are disclosed. Some embodiments include methods and devices for inducing an inflammatory response and development of fibrosis, collagen, and / or scar tissue. In some embodiments, scaffolds may be composed of a matrix of filaments. Application of the methods and devices disclosed herein to treat Gastroesophageal Reflux Disease (GERD) and other sphincter disorders are discussed. Biodegradable scaffolds configured to induce an inflammatory response are also disclosed.

Electrical activity is sensed from a plurality of electrodes of a multi-electrode catheter. For each of a plurality of surface locations of cardiac tissue, a processor identifies first electrical signals originating at a first depth and second electrical signals originating at a second depth, estimates a first near-field signal originating at the first depth for each of the first electrical signals and detects scar borders at the first depth based on the first near-field signals, and estimates a second near-field signal originating at the second depth for each of the second electrical signals and detects scar borders at the second depth based on the second near-field signals. Based on the scar borders detected at the first and second depths, the processor visually displays first and second maps of the heart depicting scar tissue at the first and second depths, respectively.

Disclosed by the present invention are an antibacterial polypeptide compound, a medical device, hydrogel and a use thereof. The antibacterial polypeptide compound has high antibacterial activity, high enzymatic hydrolysis stability, high bioavailability and low cytotoxicity. The hydrogel of the present invention does not adhere to wounds, has antibacterial activity and hemostatic properties, and can be used for loading and controlled-release of a drug, for example, an anti-inflammatory drug, an epidermal growth factor, a vascular growth factor or the like may be loaded; moreover, the hydrogel may accelerate healing of the wounds and reduce the formation of scar tissue fibers. In addition, the preparation method of the hydrogel of the present invention involves few processing steps and few types of raw materials and is convenient to perform.

The invention discloses an intelligent suturing system and method for a caesarean scar uterus, and aims to solve the technical problems of low suturing precision and high complication risk caused by scar tissues. The system comprises a data acquisition module for acquiring mechanical and image data through an intelligent suture needle integrated with a sensor and an image acquisition device; the processing module is used for segmenting a scar boundary by adopting a deep learning model and fusing data to generate an individualized stitching strategy; the mechanical execution module is used for executing stitching according to the strategy; and the augmented reality navigation module is used for superposing virtual information on the reality view for guiding. And the processing module is also used for performing closed-loop feedback adjustment on the suture operation based on the mechanical data monitored in real time. Through closed-loop control of multi-mode perception and AI decision, individualized precise suturing of scar tissue is achieved, and the operation safety and effect are remarkably improved.

The invention provides a construction method and application of an artificial scar-like organ based on a micro-fluidic chip, the artificial scar-like organ is constructed based on the micro-fluidic chip with multiple channels, the tissue microenvironment can be accurately controlled through a micro-fluidic technology, and the tissue microenvironment can be accurately controlled. And epidermis, dermis and vein endothelial cells from a human body can be subjected to differential culture through design of different channels, so that a humanized scar tissue model which is more simulated compared with a traditional method is constructed. The device has the advantages of being small in size, good in visibility, derived from a human body and capable of being stored for a long time. Therefore, the model can be prepared on a large scale for scar drug treatment effect research, and experimental materials and research bases can be provided for treatment prescriptions of pathological hypertrophic scars caused by wounds and burns.

The invention discloses a dielectric material for a brain-computer interface, a brain spine interface or an eye-computer interface and application of the dielectric material. The dielectric material comprises a 3D cell layer, the 3D cell layer is prepared from a membrane matrix and cells; the cells are selected from autologous oral mucosa epithelial cells, allogenic umbilical cord mesenchymal stem cells or allogenic amniotic mesenchymal stem cells; according to the medium material, the biological compatible material is adopted, so that the immune rejection reaction between an implanted chip and human tissues can be reduced, the service life can be prolonged, the contact mode of the implanted chip and brain tissues can be optimized, the stability and integrity of signal acquisition are ensured, and signal abnormity is avoided; meanwhile, the infection risk can be reduced, and formation of colloid scar tissue can be prevented. Wide application prospects are realized.

The invention discloses an asiatic acid nano-structure lipid carrier and a soluble microneedle drug delivery system, which are characterized in that the dosage form of asiatic acid is designed and optimized, and a drug is prepared into the nano-structure lipid carrier to improve the absorption of the drug, so that the drug effect of asiatic acid is maximized, and the drug delivery efficiency is improved. A soluble microneedle drug delivery system based on a soluble microneedle is designed, the microneedle is combined with an asiatic acid nano-structure lipid carrier, thickened scar tissue is punctured in a novel local percutaneous delivery mode, percutaneous absorption of insoluble traditional Chinese medicine ingredients can be promoted, and the curative effect is improved. According to the microneedle-nanostructure lipid carrier, the physical and chemical infiltration enhancing advantage of the microneedle-nanostructure lipid carrier is fully played, the percutaneous infiltration amount is increased, the problem of low drug absorption efficiency caused by scars is solved, and the adverse reaction of the drug is reduced by utilizing the slow release characteristic of the nanostructure lipid carrier, so that the effects of enhancing efficacy and reducing toxicity are achieved.

Devices and methods for treatment of bodily lumens and sphincters are disclosed. Some embodiments include methods and devices for inducing an inflammatory response and development of fibrosis, collagen, and / or scar tissue. In some embodiments, scaffolds may be composed of a matrix of filaments. Application of the methods and devices disclosed herein to treat Gastroesophageal Reflux Disease (GERD) and other sphincter disorders are discussed. Biodegradable scaffolds configured to induce an inflammatory response are also disclosed.

A method of draining a lymphatic system of a patient postoperatively using various physical techniques, many applied manually, including microcurrent, plastic wrap, suction cup, shockwave(s), lipolaser light and ultrasound. The method provides for reducing pain, swelling, preventing scar tissue, treating scar tissue, improving body shape, optimizing plastic surgical results, cell oxidation and improved healing through stimulated drainage of the lympathic system.