57 results about "Scar tissue" patented technology

The invention discloses a structural bionic space-time coupled axon guidance-synchronous degradation type nerve implant as well as a preparation method and application thereof. According to the preparation method, after collagen and polyvinyl alcohol are compounded, freeze-drying is performed through a specific freeze-drying process to obtain the composite nerve implant with a bunchy multi-channel and porous structure, so that the defect that the degradation rate of a current application product is too high is overcome. The degradation rate required by the composite nerve implant is regulated and controlled according to the proportion of the composite materials, the composite materials which are rapidly degraded can be designed at the two ends of the composite nerve implant with the long length, and the composite materials which are slowly degraded can be designed at the middle part of the composite nerve implant with the long length, so that the mechanical performance required by nerve regeneration is supported. The obtained nerve implant not only is beneficial to preventing cicatrix tissues from entering, but also can be used as a topographic clue of nerve regeneration related cells to guide nerve regeneration, in addition, the degradation rate of the material is synchronous with the nerve regeneration process, and finally, the material is continuously degraded along with nerve regeneration and is replaced by new tissues.

The invention discloses a registration method based on a three-dimensional retina OCT (Optical Coherence Tomography) image, which relates to the technical field of OCT image registration, and comprises the following steps of: in the registration process of the OCT image, firstly, carrying out preliminary registration by taking anatomical feature points of the retina as key references of basic alignment, and eliminating global mismatching errors; after the preliminary registration is completed, the OCT image is divided into a plurality of sub-regions in an equal area, and each sub-region is used as an independent analysis unit, thereby facilitating the subsequent precise analysis of the local optical characteristics of each analysis unit. According to the method, global errors are eliminated through initial registration of retina anatomical feature points, image division and abnormal signal extraction are combined, healthy and scar tissue areas are intelligently recognized through a machine learning model, weights are dynamically adjusted to preferentially depend on the healthy areas, interference of scars on registration is reduced, registration reliability is improved, clinical misjudgment is reduced, and the accuracy of registration is improved. And technical support is provided for accurate diagnosis and treatment of retinopathy.

The invention provides a method for three-dimensional visualization of heart scars, a control device and a storage medium, and belongs to the technical field of three-dimensional heart modeling and visual display. The method comprises the following steps: matching a heart structure obtained by segmenting a pre-trained nnU-Net and a binary tag graph corresponding to a scar tissue with a myocardial shape shown by the binary tag graph of the heart structure by using a standard myocardial grid model as a template; and fitting deformation parameters of a standard myocardial grid model by using a deep learning regression model, and applying the deformation parameters to a standard grid to complete grid deformation so as to fit individual myocardial morphology. The heart shape prior is effectively utilized based on the template deformation method, so that the reconstructed three-dimensional model has higher anatomical consistency and fineness. And superposing the fitted three-dimensional myocardial grid model and the reconstructed scar tissue grid under the same coordinate for registration and superposition to realize image three-dimensional transparent myocardial scar visualization so as to accurately restore a continuous three-dimensional scar surface.

Disclosed examples include technology for the detection and treatment of neotissue formation proximate an implantable stimulator. Neotissue formation can include ossification, scar tissue, soft tissue fibrosis, and other tissue growth. The neotissue formation can be detected by analyzing (e.g., using a machine-learning framework) stimulation data relating to the implantable stimulator. Neotissue formation characteristics can be analyzed to determine appropriate treatment actions for ameliorating the effects of neotissue formation.

The invention provides a real-time analysis method for energy distribution of an ultrasonic hemorrhoid therapeutic apparatus, which comprises the following steps of: defining a boundary region of an initial displacement distribution map by using a boundary region of recurrent internal hemorrhoid and scar tissue, and extracting differential mechanical response characteristics of the boundary region, identifying the position of a high strain set area of the differential mechanical response characteristics as a shear strain concentration area; analyzing a strain value of the position of the shear strain concentration area, and if the strain value exceeds a preset strain threshold value, analyzing sound beam path deviation caused by sound radiation force pulse refraction in the scar tissue through two-dimensional correlation to obtain focus offset; adjusting the displacement distribution diagram through the boundary of the energy deposition region, and extracting the mechanical property distribution of the boundary region to obtain the energy deposition distribution of the target hemorrhoid tissue; and through the energy deposition distribution of the target hemorrhoid tissue, optimizing sound beam deflection parameters, obtaining target sound beam control parameters, and determining an energy deposition area.

The invention discloses a preparation method of composite microspheres for regulating and controlling a local inflammation microenvironment and promoting nerve regeneration. The method comprises the following steps: preparing liposome loaded with ginsenoside Rg1; preparing a GM microsphere loaded with a stromal cell-derived factor 1 alpha (SDF1 alpha); and preparing the inflammation regulation nerve regeneration promoting composite microspheres. The composite microsphere can reduce inflammatory response, reduce scar tissue formation, promote angiogenesis, continuously release SDF1 alpha and promote endogenous stem cell recruitment and neural differentiation. Therefore, the composite microsphere is a functional biological scaffold for firstly regulating and controlling local microenvironment inflammation of spinal cord injury and then promoting collection and differentiation of endogenous stem cells for innovative sequential inflammation regulation and nerve regeneration, and a new strategy is provided for treating spinal cord injury by tissue engineering.

The invention discloses a cicatrix tissue blood flow contrast quantitative evaluation device and method, and relates to the field of cicatrix evaluation. The device comprises a diffusion correlation spectrum module, a quantitative evaluation module and an optical probe, and the diffusion correlation spectrum module is used for sending near-infrared light to a detected tissue, detecting scattered light spots of a detected area and calculating a light intensity autocorrelation function according to the scattered light spots; the quantitative evaluation module is used for controlling acquisition of the diffusion correlation spectrum module, storing the acquired data, calculating a blood flow index BFI, calculating a comparison quantitative evaluation parameter Qs for evaluating the scar according to BFI real-time data, and displaying an output result; the optical probe is used for transmitting and diffusing near-infrared light of a related spectrum to the surface of a detected tissue, and receiving scattered light spots after diffuse reflection of the detected tissue to the detection module. According to the quantitative evaluation method, BFI collection of the tested tissue is completed through the device, Qs is calculated, and quantitative evaluation of the scar is achieved. The method overcomes the defects that the influence of subjective factors is large, and the restoration stage cannot be evaluated.

The microneedle transdermal drug delivery device comprises a base and a microneedle body, the microneedle body is conical and comprises a needle body and a needle tip, a hollow needle tube is arranged in the needle tip, the needle body is in threaded fit with the base, a needle body adjusting mechanism is arranged in the base, the end of a drug delivery tube is inserted into the needle body, one end of the drug delivery tube is connected with the needle body, and the other end of the drug delivery tube is connected with the needle tip. One end of the medicine feeding pipe is connected with the base, the other end of the medicine feeding pipe is opened and penetrates through the middle of the base, a threaded groove matched with a medicine bottle in a threaded mode is formed in the portion, on the outer side of the opening of the medicine feeding pipe, of the base, a medicine pump is arranged in the medicine feeding pipe, and a liquid level sensor is arranged at the portion, between the medicine feeding pipe and the threaded groove, of the base. According to the medicine feeding device, the medicine quantity is better controlled, medicine feeding is deeper, the needle body enables medicine to deeply and effectively penetrate into scar tissue, the electronic display screen is adopted to adjust and select the medicine feeding dosage by controlling the medicine pump, and a user can conveniently and accurately grasp the medicine feeding dosage through the electronic display screen.

In some examples, a tool for, e.g., creating a sub-sternal tunnel in a patient or other use, is described. The tool may include a handle and a tunneling shaft coupled to the handle. The tunneling shaft extends from a proximal end to a distal end, and at least a portion of the tunneling shaft extends in a curved orientation between the first end to the distal end. The distal end of the tunneling shaft includes a cutting tool having a sharp edge. The cutting tool is moveable from a recessed position in which the sharp edge of the cutting tool is recessed into the distal end of the tunneling shaft to a deployed position in which the sharp edge of the cutting tool extends beyond the distal end of the tunneling shaft in the deployed position, e.g., to cut pericardium, scar tissue, and / or connective tissue with the sharp edge.

The utility model discloses an indwelling injection treatment device, and relates to the technical field of medical instruments, the indwelling injection treatment device is used for keloid treatment, the indwelling injection treatment device comprises a shell, an injection device and a plurality of fixing bands, the shell is provided with a cavity with a bottom opening; the injection device is located in the cavity and comprises a liquid storage barrel and at least one indwelling needle, the liquid storage barrel is used for storing liquid medicine, the indwelling needle is communicated with the liquid storage barrel, the indwelling needle is arranged towards the opening of the shell, and the indwelling needle is used for being indwelled in scar tissue; the injection device is used for injecting liquid medicine into scar tissues; the fixing band is detachably connected with the shell, and the fixing band is used for fixing the shell on the scar tissue. The keloid injector aims at enabling a keloid patient to perform injection operation at home without going back and forth to a hospital for many times.

A method for treating cellulite on a patient's skin is provided. The method includes identifying at least one region of said patient's skin with cellulite. The method further includes generating at least one scar tissue in at least one tissue portion in said region of skin, thereby generating at least one septa-like scar tissue in said region of said patient's skin. The step of generating at least one septa-like scar tissue in said region of said patient's skin treats cellulite.

This invention provides a pH-responsive immunomodulatory microneedle patch, its preparation method, and its application, belonging to the field of biomedical materials technology. This invention incorporates Zif-8 nanoparticles loaded with ChABC into GelMA hydrogel to prepare a pH-responsive immunomodulatory microneedle patch (Z@C-MN). As the patch gradually degrades, the system can continuously release Zn in a pH-responsive manner. 2+ Z@C-MN, along with ChABC, promotes in situ repair of cerebral fibrosis (SCI) after injury. Z@C-MN induces macrophage polarization towards a pro-regenerative phenotype, thereby downregulating the inflammatory response, increasing neurite length, and promoting the differentiation of neural stem cells into neurons. In vivo, Z@C-MN reduced the inflammatory microenvironment after injury and promoted angiogenesis in a rat SCI model. Furthermore, it activated axonal regeneration by inhibiting scar tissue formation and regulating CD4+. + T cell transformation supports neurogenesis.

To provide a method for suppressing the entry of scar tissue in the treatment of a tendon or ligament, promoting healing by intratendinous cells, and efficiently restoring the original function of the tendon.A gel material including a polymer gel for suppressing expression of type III collagen in the treatment of an injured or ruptured tendon or ligament, in whichthe polymer gel is a hydrogel having a three-dimensional network structure formed by crosslinking of hydrophilic polymers, and has a polymer content of from 1 to 5% by weight and an elastic modulus of from 100 to 10000 Pa.

The present disclosure relates generally to the use of medical instruments for treating chronic venous disease and collagenous scar tissue. In particular, the present disclosure provides methods and systems for remodeling collagen obstructions using energy and expandable catheters.

The invention relates to a myocardial scar weak supervision segmentation method fusing a distance map and uncertainty, and belongs to the field of image segmentation. According to the method, the myocardial scar area is marked in a graffiti form, the marking cost is remarkably reduced, and the distance map is generated through graffiti and is used for constraining network prediction, so that the perception ability of the network to the scar boundary is improved; and meanwhile, an uncertainty estimation mechanism is introduced to further refine the segmentation result, and the scar tissue detection capability of the model under a weak supervision condition is enhanced. According to the method, the performance bottleneck existing when an existing weak supervision method processes category imbalance and boundary fuzziness is effectively solved, and the accuracy and robustness of myocardial scar segmentation are improved.

The invention discloses a reverse glaucoma filtering bleb scar probe, comprising a needle stem in an arc shape and bendable into any arc, the specification of the needle stem is 24G to 26G, an axe-shaped blade is arranged at the needle tip, the bevel of the needle tip is flush with the blade surface of one side of the blade, and a needle plug is arranged at the tail of the needle stem for connecting with a syringe barrel containing a viscoelastic agent. After the filtering bleb of glaucoma trabeculectomy loses its function, reverse scar separation can be performed through a limbal incision through the anterior chamber, the needle plug is connected to the syringe, and the syringe is used as a handle during separation, the needle stem is bent into any arc to change the separation direction, and a wide separation can be performed through a tiny limbal incision, the axe-shaped blade is in linear contact with the scar tissue, the separation surface is relatively smooth, and the viscoelastic agent can be injected while separating to avoid causing new damage, and a trabecular surgery can be ensured once, and the reverse separation with the probe is timely used to maintain the filtering function for life, avoid multiple surgeries, and reduce the pain of patients.

The invention belongs to the technical field of biology, and mainly relates to a preparation method and application of N1, N10-bisdihydrodicaffeoyl spermidine. According to the invention, the spermidine component N1, N10-bisdihydrodicaffeoyl spermidine of lycium ruthenicum is obtained through water extraction, macroporous resin separation and preparative liquid chromatography purification. The purity of the N1, N10-bisdihydrodicaffeoyl spermidine obtained by the preparation method disclosed by the invention is high and reaches 98% or above. The prepared N1, N10-bisdihydrodicaffeoyl spermidine can directly activate the activity of G6PD, improve the NADPH (nicotinamide adenine dinucleotide phosphate) level, improve the heart function in a dose-dependent manner, and reduce the formation and fibrosis of scar tissues. Under a high dose (20mg / kg / day), the protection effect of the N1, N10-bisdihydrodicaffeoyl spermidine on myocardial deficiency-reperfusion injury is equivalent to that of metoprolol tartrate (MTA), and the N1, N10-bisdihydrodicaffeoyl spermidine can be used for preparing a product for preventing and treating ischemia-reperfusion injury.

The invention discloses a human umbilical cord mesenchymal stem cell exosome for treating scars and a preparation method of the human umbilical cord mesenchymal stem cell exosome. The exosome is extracted from human umbilical cord mesenchymal stem cells pretreated by extracellular vesicles in scar tissues. The human umbilical cord mesenchymal stem cell exosome can be used for preparing medicines for improving and treating scars, has a potential action effect on early scar treatment, and has important significance on improving the scar treatment effect and improving the life quality of patients.

The invention discloses a novel anti-pipe-blocking drainage device which comprises a main hose, a pipe core, a spring, a pipe cap and a core spring limiting clamping sleeve. The main body hose comprises a drainage part at the front section, a communication part in the middle and a mounting part at the tail part, a plurality of drainage holes are formed in the drainage part, the communication part is provided with a leading-out hose, a core spring limiting clamping sleeve is arranged in the mounting part, and a spring is arranged in the core spring limiting clamping sleeve; the tube core is inserted into the main body hose and performs axial and circumferential movement. The problem that thick blockages are difficult to discharge is solved through rotation, advancing and retreating movement of the tube core and synapses in movement, the synapses on the tube core can scrape off hyperproliferative granulation entering a tube cavity, and thick bloody secretions and the like are discharged; the problems that granulation tissue entering the lumen is excessively proliferated, fibroblast scar tissue hyperplasia is caused for a long time, and the lumen and body tissue are connected into a whole are effectively avoided, and therefore the possibility that tube drawing is difficult and even secondary operation tube drawing is likely to happen is avoided.

A portable knee bend exercise apparatus which allows for controlled use of the knee joint for exercise movements so as to reduce or prevent the buildup of scar tissue and to strengthen muscles around the joint. The portable knee bend exercise apparatus includes a wedge body having a support portion suitable to receive the thigh of a user, a lip portion suitable to provide an axis of rotation about which a knee can perform extension and flexion, a tapering portion which allows for full knee flexion, a bottom portion, and a back portion suitable to couple with a seat on which a user in seated. Coupled with the wedge body is a strap member which is structured to both encircle the wedge body and extend above the top surface to selectively form a loop which can secure the leg of a user to the top surface.

Electrical activity is sensed from a plurality of electrodes of a multi-electrode catheter. For each of a plurality of surface locations of cardiac tissue, the processor identifies a first electrical signal originating from a first depth and a second electrical signal originating from a second depth, estimating, for each of the first electrical signals, a first near-field signal originating from the first depth and detecting a scar boundary at the first depth based on the first near-field signal, and estimating, for each of the second electrical signals, a second near-field signal originating from the second depth and detecting a scar boundary at the second depth based on the second near-field signal. Based on the scar boundary detected at the first depth and the second depth, the processor visually displays first and second maps of the heart depicting scar tissue at the first and second depths, respectively.

The invention discloses recombinant collagenase as well as a preparation method and application thereof, and belongs to the technical field of biochemical engineering. The recombinant collagenase provided by the invention is prepared from HmCol and / or CbCol, the amino acid sequence of the HmCol is as shown in SEQ ID NO: 1; the amino acid sequence of the CbCol is as shown in SEQ ID NO: 2. Recombinant collagenase hydrolytic activity experiment results show that the expressed recombinant collagenase HmCol and CbCol can recognize recombinant collagen of different sources, including fragments of human III-type collagen recombined and expressed by escherichia coli, yeast and Chinese hamster ovary cells (CHO), so that the specificity and efficient hydrolysis of the collagen are realized, and the recombinant collagenase HmCol and CbCol can be used for identifying the recombinant collagen of different sources. The material has good application prospects in the aspects of scar tissue repair, low-temperature cold compress debridement and the like, and can be used as a raw material for preparing skin repair products.

The present disclosure relates to electroanatomical mapping of cardiac tissue at different depths using a multi-electrode catheter. A multi-electrode catheter within a patient's heart has a plurality of first electrodes on a first side adjacent to heart tissue at a first location and a plurality of second electrodes on a second side facing away from the heart tissue. Electrical activity is received from at least one electrode on the first side and at least one electrode on the second side, and a signal analysis is performed thereon based at least in part on a distance between electrodes on different sides of the multi-electrode catheter. The process is repeated for further locations of heart tissue in the heart and an electroanatomical map of the heart depicting electrical activity or scar tissue is generated based on the signal analysis.

The present disclosure relates to compositions and methods for preventing, reducing and / or treating scars. The composition comprises at least one C-glycoside or derivative thereof, and the method comprises treating the skin and / or scar tissue with at least one C-glycoside or derivative thereof and at least one skin modification stimulant.

The invention discloses a multifunctional targeting hydrogel based on chiral polypeptide as well as a preparation method and application thereof, and the multifunctional targeting hydrogel based on chiral polypeptide comprises the following raw materials in parts by weight: targeting nanoparticles loaded with a TGF-beta inhibitor, chiral antioxidant polypeptide, a cross-linking agent and water. The multifunctional targeted hydrogel has the functions of MI early-stage efficient ROS removal and MI late-stage targeted fibrosis blocking, has the functions of remodeling the infarction area microenvironment, inhibiting scar tissue expansion and recovering cardiac muscle synchronous electrical conduction, and finally achieves coordination of hydrogel degradation kinetics and the heart repair process and multi-dimensional repair of damaged cardiac muscle.

The invention provides a deep learning-based scalp health condition detection method and system, and relates to the technical field of image data processing, and the method comprises the steps: obtaining dermatoscope images and optical coherence tomography data of different scalp regions; constructing a voxel model with epidermis morphological characteristics and subcutaneous tissue scattering characteristics according to optical coherence tomography data; performing multi-layer convolution and pooling operation on the voxel model by using a pre-trained convolutional neural network to extract a high-dimensional feature vector; mapping the high-dimensional feature vector to a low-dimensional space by using a manifold learning algorithm, and calculating a target distance; on the basis of the target distance, the scalp area where the tissue type is the scar lesion type is marked as the irreversible alopecia area, so that detection of the scalp health condition is completed, subcutaneous hair follicle structure disappearance and fibrosis scar tissue are accurately distinguished under the non-invasive condition, and the detection accuracy is improved. The accuracy of scar alopecia judgment and the reliability of irreversible alopecia area recognition are improved.

The present disclosure relates to a system comprising an electrical interface and a processor. The electrical interface is configured to communicate with a probe inserted into a patient's heart. The processor is configured to receive via the electrical interface (i) a first indication of an electrical impedance measured by the probe at a given location on an inner surface of the heart, and (ii) a second indication of the quality of mechanical contact between the probe and the inner surface of the heart during the measurement of the electrical impedance. The processor is further configured to classify tissue at the given location as scar tissue based on the first indication and the second indication.

A method for treating cellulite on a patient's skin includes identifying at least one region of said patient's skin with cellulite. The method includes generating at least one scar tissue in at least one tissue portion in said region of skin, thereby generating at least one septa-like scar tissue in said region of said patient's skin. The method further includes stabilizing said at least one septa-like scar tissue. Generating at least one septa-like scar tissue in said region of said patient's skin treats cellulite.

The utility model discloses a skin taking and grafting mobile phone with a graduated drill bit and an adjusting cap, and relates to the technical field of scar regeneration skin taking and grafting medical treatment. The skin taking and grafting mobile phone with the scale drill bit and the adjusting cap comprises a mobile phone rear cap and the scale drill bit, the outer wall of the mobile phone rear cap is in threaded connection with a motor sleeve, a rotating groove is formed in the outer wall of the motor sleeve, the outer wall of the motor sleeve is rotationally connected with a rotating cap, and the outer wall of the bottom end of the motor sleeve is in threaded connection with a mobile phone front cap; the bottom end of the mobile phone front cap is in threaded connection with an adjusting cap; a motor is fixedly connected in the motor sleeve, an output shaft of the motor is connected with a main shaft, one end of the main shaft is provided with a three-petal spring, and the three-petal spring clamps and fixes one end of the scale drill bit. A medical worker holds the shell of the skin taking and grafting mobile phone, a doctor evaluates the drilling depth according to the thickness of scar tissue of a patient so as to efficiently and conveniently adjust the depth of the scale bit, and due to the fact that laser-engraved scale marks are arranged on a tube body of the scale bit, the doctor can visually inspect the needle inserting depth, and accurate, efficient and precise treatment is achieved.

A surgical suturing device includes a suture needle configured to reliably pass through typically thick scar tissue present along, for example, the edge of a midline hernia. The surgical suturing device includes a first clamp and a second clamp. The suture needle is selectively supported on the first clamp or the second clamp at an acute angle, for example, relative to a longitudinal axis defined by the corresponding first clamp or second clamp. The suture needle can be selectively secured to the first clamp or the second clamp via a first needle-receiving leaflet and a second needle-receiving leaflet configured for reciprocating axial displacement. A suture thread is connected to the suture needle to perform tissue suturing.