14 results about "Acoustic radiation force" patented technology

This invention discloses a method for the synergistic metabolic analysis of multiple components of traditional Chinese medicine (TCM) integrated with the gut microbiota. After initializing the microbiota ecosystem, a solution of multi-component TCM extracts is continuously injected into a microfluidic chip. Stable isotope-labeled precursors are pulsed into a specific simulation region to perform spatial isotope encoding. A standing wave acoustic field is applied at the sampling node of the microfluidic chip, and multiphase fluid spatial splitting is performed using the difference in the primary acoustic radiation force experienced by the particles to derive cell-free TCM metabolites. The cell-free TCM metabolites are separated by chromatography and gas phase drift separation. A four-dimensional metabolic feature array is constructed, and the absolute value of the mass shift is calculated for spatial inverse decoding. Closed-loop feedback is triggered based on the rate of change of target metabolite ion abundance, increasing the amplitude of the standing wave acoustic field pressure to confine intestinal bacteria and performing in-situ enrichment of synergistic metabolic intermediates. This invention realizes the spatial metabolic trajectory tracing and network reconstruction of multiple components of TCM in a complex gut microbiota ecosystem.

The application belongs to the field of physical property measurement, and discloses a kind of electroplating additive concentration on-line detection method and system based on multispectral fusion, comprising: guiding flow electroplating liquid through detection cell, control transducer array to generate sub-cavitation megahertz standing wave field, utilize acoustic radiation force to drive free gas bubble to gather to wave crest area, make nodal area form the light path of no scattering interference;Real-time monitoring impedance phase, when reaching resonance extreme point, produce synchronous trigger signal, drive light source to emit ultraviolet wave band light beam, visible wave band light beam and near infrared wave band light beam to light path;Extract the intensity correction absorption brightness parameter of main salt reference wavelength, obtain response sequence and output additive concentration, the application reconstructs the phase distribution of measurement environment, blocks random scattering to the erosion of spectral information, ensures the fidelity of measurement data corresponding to physical fact, solves the problem that trace component signal is hidden in complex matrix.

A viscoelasticity measurement method (100, 700) and an ultrasonic measurement system (1000), the viscoelasticity measurement method (100, 700) comprising: emitting an acoustic radiation force pulse to a subject to be measured to generate a shear wave in a region of interest of the subject to be measured (S110); emitting a first ultrasonic wave to track the shear wave to the region of interest and receiving a first ultrasonic echo of the region of interest to obtain first ultrasonic echo data (S120); obtaining a shear wave signal of the region of interest from the first ultrasonic echo data (S130); extracting shear wave components of at least two different frequencies from the shear wave signal (S140); determining phase velocities of the shear wave respectively according to the shear wave components of the at least two different frequencies (S150); determining viscosity information reflecting viscosity of the region of interest according to the at least two phase velocities (S160); and outputting the viscosity information (S170). The viscosity information of the region of interest can be determined by one viscoelasticity measurement.

Provided are systems and methods of delivering an exogenous payload to a cell in a tissue of a subject, including: administering an exogenous payload to the subject; administering a sonoactive agent to the subject, and applying an acoustic radiation force (ARF) to the subject, thereby generating shear waves in the tissue of the subject, wherein the acoustic radiation force enhances delivery of the exogenous payload to the cell in the tissue of an organ of the subject.

Provided in the present invention are a control method and system for an acoustic radiation force of ultra-high frequency ultrasound. The method comprises: aligning an acoustic beam of ultra-high frequency ultrasound with an object under force; setting a carrier voltage of a pulse signal, such that an acoustic radiation force reaches a preset magnitude; adjusting a pulse width of the pulse signal; after adjusting the pulse width, determining whether the object under force meets a preset driving effect, and if so, ending the method; and if not, fine tuning the carrier voltage, and returning to adjusting the pulse width until the object under force meets the preset driving effect. In the technical solution of the present invention, a carrier voltage and a pulse width are adjusted on the basis of a preset driving effect of an object under force, such that the technical solution can be applicable to different driving effects and has a wide application range.

The application relates to the technical field of biomedical engineering, and discloses a method for constructing an ex vivo normal-temperature perfusion repair model based on a discarded liver. The method constructs a double-path closed-loop perfusion system, applies a shear stress flow field with low-frequency fluctuation characteristics to a portal vein loop to maintain endothelial function, loads a composite flow field obtained by superimposing low-frequency pulsation and high-frequency micro-shaking on a hepatic artery loop, and significantly reduces microcirculation flow resistance by using the thixotropy and shear thinning characteristics of oxygen-containing perfusion liquid. The system further realizes physical layering of red blood cells and lipids by using acoustic radiation force of a standing wave acoustic flow control layered cavity, and automatically guides a high-viscosity fat-rich flow layer into an adsorption module for specific purification by cooperating with a thixotropic passive shunt valve based on fluid viscosity feedback. Temperature-gas coupling adjustment based on a metabolic temperature coefficient is performed in a rewarming stage. The application solves the problems of microcirculation non-recurrent flow and hyperlipidemia clearance by coupling of multi-dimensional physical fields, and realizes effective repair of the discarded liver.

The application provides a flow cytometer, a method and an acoustic particle manipulation microfluidic chip, and relates to the field of flow sorting. The liquid flow system of the flow cytometer comprises an acoustic particle spacing adjustment unit. The acoustic particle spacing adjustment unit is configured to generate an acoustic standing wave field in a sample flow channel. The nodal line or nodal surface of the acoustic standing wave field is perpendicular to the liquid flow direction. Particles are moved to the nodal line or nodal surface under the action of acoustic radiation force, so that the particles are arranged at a preset spacing along the liquid flow direction. The application uses a specially designed microfluidic channel and a piezoelectric acoustic device to adjust the spacing of particles in the sample flow, so that the particles are uniformly distributed, the probability of being wrapped by the same droplet is reduced, and the sorting yield is improved. The acoustic focusing technology is used to focus the particles to the acoustic nodal line position in advance before the sheath liquid is focused. The width of the acoustic nodal line is small, which can ensure the consistency of the particle position and the flow rate under high sample flow rate, and improve the sorting purity and yield.

A non-invasive apparatus and method for detaching and removing gas bubbles from surfaces, such as electrodes, and from bulk liquids using acoustic radiation force, are described. The application of acoustic waves to bubble removal from electrolyzers and gas-liquid separator vessels enhances hydrogen production efficiency. Hydrogen bubbles are smaller in size and will be more responsive to higher frequencies, whereas oxygen bubbles are relatively larger in size and will be more responsive to a relatively lower frequency. For each of the electrodes, the bubble diameters also change along the height of the electrolyzer cell; therefore, a range of frequencies is advantageous. To produce multiple frequencies in the fluid mixture, the same transducer was simultaneously excited at two distinct frequencies, f 1 and f 2 simultaneously, leveraging the highly non-linear characteristics of bubbly fluids to facilitate frequency mixing, resulting in the emergence of frequencies such as mf 1 ± nf 2 within the fluid medium (m and n are integer numbers).

This invention discloses a three-dimensional visualization organoid culture device, belonging to the field of organoid culture technology. It includes a control center, which is communicatively connected to a virtual three-dimensional scaffold module, a laser visualization monitoring module, a biolayer interference sensing module, and an automated culture medium control module. This invention abandons the traditional matrix gel solid scaffold and employs focused acoustic vortex technology to construct a dynamically adjustable virtual acoustic trap array. It utilizes acoustic radiation force to achieve cell capture and spatial arrangement, avoiding the interference of uncertainties in the composition and biocompatibility differences of solid scaffolds on organoid growth. Simultaneously, the acoustic trap array can adaptively reconstruct its topology according to the cell aggregation stage and metabolic state, solving the problem that traditional scaffold structures cannot adapt to dynamic cell growth, improving the morphological uniformity and physiological relevance of organoids, and providing a high-quality culture medium for organoid research and clinical applications.

The application provides a device and method for measuring the ultrahigh frequency ultrasonic acoustic radiation force on an object, wherein the device comprises an elastic force receiving component, an ultrahigh frequency ultrasonic transducer and a displacement measuring device, the elastic force receiving component comprises a glass capillary and an object, the lower end of the glass capillary is a fixed end, the upper end of the glass capillary is a free end, and the object is fixed to the upper end of the glass capillary; the ultrahigh frequency ultrasonic transducer is located on the side of the object, the ultrahigh frequency ultrasonic transducer is used to generate ultrahigh frequency ultrasonic waves according to an excitation signal, and the object moves axially and laterally under the action of axial and lateral ultrasonic acoustic radiation forces; and the displacement measuring device is arranged above the object and is used to measure the axial and lateral displacements of the object under the action of the axial and lateral ultrasonic acoustic radiation forces. The device can be used to simultaneously measure the axial and lateral ultrasonic acoustic radiation forces on the object.

The application provides a kind of acoustic radiation force control method and system of ultra-high frequency ultrasound, comprising: the sound beam of ultra-high frequency ultrasound is aimed at force object;Carrier voltage of pulse signal is set, so that acoustic radiation force reaches preset magnitude;Adjust the pulse width of pulse signal;After adjusting the pulse width, it is judged whether force object satisfies preset driving effect, if yes, end;If not, then fine-tune carrier voltage, and return to adjust pulse width, until force object satisfies preset driving effect.The technical scheme of the application, according to the preset driving effect of force object, carrier voltage and pulse width are adjusted, which can be applied to different driving effects and has wide application range.

This invention discloses a drug enrichment system, comprising: a sound field generating device, which includes a focusing transducer for generating a focused sound field, the transmitter of which faces a fluid cavity within a human or animal body to be enriched; drug-loaded particles are injected into the fluid cavity, and the focusing transducer is controlled to generate a frequency-adjustable focused sound field, thereby enriching the drug-loaded particles at a preset target location. The preset target location is located on the plane of the focusing transducer's emission focal point. The sound field generating device further includes a signal generator and a power amplifier. The sound field generating device, through the signal generator and power amplifier, controls the focusing transducer to emit a swept-frequency sound field that causes sound field nodes to move directionally along the sound wave propagation direction, causing the drug-loaded particles to migrate directionally with the moving sound field nodes under the action of the acoustic radiation force generated by the swept-frequency sound field.

The application relates to a defoaming device and a defoaming system. The defoaming device comprises a defoaming container, a vacuum generator and an ultrasonic generator. The defoaming container is provided with a containing cavity, the air inlet of the vacuum generator is communicated with the containing cavity, the ultrasonic generator comprises a transducing assembly and a vibrating piece, the output end of the transducing assembly and the vibrating piece are located in the containing cavity, and the vibrating piece is connected to the output end of the transducing assembly. The defoaming container of the defoaming device can contain photosensitive glue, the vacuum generator is communicated with the containing cavity of the defoaming container through the air inlet and extracts the gas in the containing cavity. The transducing assembly in the ultrasonic generator can convert electric energy into mechanical energy, the vibrating piece transmits the ultrasonic energy generated by the transducing assembly to the photosensitive glue, the ultrasonic wave generates a cavitation effect in the photosensitive glue, forms tiny bubbles, the acoustic radiation force generated by the ultrasonic wave pushes the bubbles to move and gather, accelerates the bubbles to float and escape, the vacuum generator extracts the escaped gas, and thus the photosensitive glue can be defoamed.