102 results about "Particle imaging" patented technology

The invention belongs to the field of image reconstruction of magnetic particle imaging and multi-modal generative artificial intelligence models, particularly relates to a magnetic particle image reconstruction method and system based on a multi-modal diffusion model, and aims to solve the problem that there is no method capable of combining a generative model and a multi-modal imaging technology to realize accurate quantitative reconstruction of MPI. The method comprises the following steps: carrying out integral modeling and discretization operation on a first excitation signal to obtain discrete signals, fitting and superposing the discrete signals to obtain a first response signal, calculating a loss function, and training a model based on the loss function; processing the second time sequence signal by using the trained particle response model to obtain a second response signal; calculating based on the second response signal and the system matrix, gradually adding noise, and constraining to obtain a noise constrained image; and gradually denoising and recovering the noise constraint image in the last step to obtain a final reconstructed image. According to the invention, rapid and high-quality MPI image reconstruction becomes possible.

The invention discloses a multi-particle three-dimensional shape reconstruction method based on projection consistency. According to the method, a three-angle laser interference particle imaging system is used for collecting out-of-focus images of three visual angles, a center M * N pixel range is cut to obtain an out-of-focus speckle image, phase recovery algorithm reconstruction is carried out, a two-dimensional particle shape is obtained, a gray threshold value above 70 is set to be a target contour area, binarization segmentation is carried out, and a target contour image is obtained. And smoothing the target contour area. And carrying out three-dimensional space projection on contours of the four candidate results in Matlab, generating a three-dimensional structure in an intersection region, re-projecting the three-dimensional structure to each view angle, calculating an error S between a re-projected image and an original input projection, and selecting a final reconstruction result with the minimum S. According to the method, through systematic iterative optimization and an error evaluation mechanism, trivial fuzzy interference in a phase recovery process is effectively eliminated, and high-precision reconstruction of a multi-particle three-dimensional shape is realized.

Several calibration methods for particle imaging systems are proposed that allow the determination of lateral focus shifts as a function of focusing changes or refocusing. Distortions in particle-optical images generated with appropriately calibrated systems can thus be reduced, and metrological investigations in these images, and especially in 3D tomography, can be performed with greater accuracy. With appropriately calibrated particle imaging systems, 3D samples, such as deep channels in semiconductor samples, can be measured more precisely. Distortion effects arising from sample geometries in electrostatic immersion fields can also be calibrated and thus corrected.

The invention provides a dynamic self-adaptive range compensator imaging system, which belongs to the technical field of particle imaging equipment, and comprises a particle track detection module used for screening particles directly penetrating through a detector, reconstructing the track and direction of particle motion, and obtaining the energy and position information when particles are incident; the self-adaptive range compensation module is used for realizing dynamic self-adaptive compensation of the particle residual range by adjusting the effective thickness of the compensator so as to receive the particle signal and obtain the residual range corresponding to the residual energy when the particle penetrates out of the imaged object; wherein the effective thickness of the compensator refers to the thickness of the compensator in the particle incidence range along the particle incidence direction; and the image processing module is used for calculating and outputting an image according to the residual range of the imaged object under the conditions of different positions and angles. Through the dynamic compensator, (quasi) continuous range compensation is realized, the precision is improved, and a better detection effect is realized while the cost is reduced.

The invention discloses a method for measuring the molar concentration of nano-particles. The method comprises the following steps: diluting a nano-particle suspension with a high-molecular polymer solution or dispersing nano-particle powder into the high-molecular polymer solution; transferring the suspension liquid to a spacing net on the side of a sample pool in an electrophoresis tank; nano-particles migrate from the sample pool to the buffer pool under the driving of the electric field and are uniformly distributed on the spacing net in a single-particle manner; performing single-particle imaging on the spacing net by using an optical microscope; and counting the number of the nanoparticles in the image so as to measure the molar concentration of the nanoparticles in the sample. The method can be used under the condition that the properties of the nanoparticles are unknown or no standard substance exists, the detection object has no additional condition, and the accuracy is high.

The present application relates to the field of magnetic particle imaging, and particularly relates to a kind of fast calibration method and system of MPI system matrix based on multi-stage wavelet transform and double branch attention network, to solve the problem of time-consuming, complex of existing calibration-based system matrix acquisition method.The method of the present application comprises: obtaining a low-resolution system matrix according to a pre-set undersampling grid;The system matrix is encoded by row RGB to obtain an RGB image;The above-mentioned RGB image is input into the trained MWaveDAN network model to obtain a high-resolution RGB image;The high-resolution RGB image is decoded into complex form to obtain a complex-based system matrix.The present application effectively accelerates the high-resolution acquisition of system matrix in MPI, and provides important support for the future development of MPI technology.

The invention relates to the technical field of magnetic particle imaging, in particular to a core-shell nanoprobe and a preparation method and application thereof.The core-shell nanoprobe comprises a magnetic core and a nanoshell which is located outside the magnetic core and has a magnetic shielding response function, and the structure of the nanoshell collapses under the tumor microenvironment condition; the saturation magnetization of the magnetic core is greater than or equal to 50 emu / g, and the coercive force is less than or equal to 5 Oe; the saturation magnetization of the nano shell is less than 50 emu / g, and the coercive force is more than 5 Oe. According to the core-shell nanoprobe, through a unique magnetic core-shell structure design and tumor microenvironment response characteristics, a magnetic shielding layer is formed by using a low-signal nano shell with a response magnetic shielding function, and background signal interference is inhibited. In a tumor microenvironment, the shell structure of the core-shell nanoprobe collapses, the magnetic core is exposed, and a high magnetic signal is released and generated, so that the imaging signal-to-noise ratio is remarkably improved. According to the invention, the bottleneck that the traditional MPI probe is lighted in the whole course can be broken through, the tumor specificity is lighted and positioned, and the problems that the external background of the tumor is high, the contrast ratio is poor, and tiny focuses are difficult to detect are solved.

The utility model relates to the technical field of multiphase flow measurement, and discloses a multiphase flow microscopic imaging measurement system based on a particle imaging technology, which comprises a multiphase flow injection system, a microscopic chip, a waste collection system, an optical system, an image acquisition system and an image processing system, the optical system is arranged below the microchip, the image acquisition system is arranged above the microchip, and the image processing system is connected with the image acquisition system. According to the utility model, through illumination of the optical system, multi-channel synchronous control of the microcosmic chip and shooting of the accurate image acquisition system, high-resolution nano particle images can be obtained, and the system is suitable for accurate measurement and analysis of multiphase flow in scientific research and industrial application, and has the advantages of high precision and high efficiency.

The invention discloses a magnetic particle imaging method based on multi-harmonic energy-full width at half maximum combined weighting, which comprises the following steps: acquiring point spread functions of a plurality of harmonic waves with different frequencies of magnetic nanoparticles, and constructing a corresponding system matrix; measuring a reference sample which does not contain the magnetic nanoparticles, and obtaining a plurality of noise matrixes corresponding to harmonic waves with different frequencies; measuring the sample to be measured, and obtaining magnetization response voltage vectors of a plurality of harmonic waves with different frequencies; respectively calculating an energy two-norm of a system matrix, an energy two-norm of a noise matrix and a full width at half maximum of a point spread function of the system matrix and the noise matrix; splicing the magnetization response voltage signals of each harmonic system matrix to form a total system matrix and a total measurement signal vector; calculating a weight factor of each harmonic wave and forming a weight matrix; and constructing a solution equation of the particle concentration distribution of the sample to be detected, and carrying out iterative solution on the solution equation to obtain a particle concentration distribution image of the sample to be detected. According to the invention, efficient utilization of multi-harmonic information is realized.

Disclosed is an imaging apparatus comprising: a segmented scintillator structure; and a photocathode structure optically coupled to the segmented scintillator structure, for conversion of high-energy particles with an arbitrary spatial distribution to a corresponding distribution of photoelectrons, emitted with a spread in energy ranging from 100 meV to 1 meV. Also disclosed is an imaging apparatus comprising: a segmented scintillator structure, and a photocathode structure optically coupled to the segmented scintillator structure, for conversion of high-energy particles with an arbitrary spatial distribution to a corresponding distribution of photoelectrons, emitted with an angular spread ranging from 10 degrees to 0.1 degrees. Also disclosed is a pressureless filling of capillary tubes and nano-molds using electroosmosis effect.

This invention provides a three-dimensional detection system for lubricating oil abrasive particles based on a phase-shifting micromirror, comprising: a light source system, a beam splitter, an abrasive particle imaging system, a phase modulation system, and a detection system; the light source system emits a parallel beam that is incident on the beam splitter; the beam splitter divides the parallel beam into two identical transmitted beams and reflected beams; the reflected beam passes through the abrasive particle imaging system and is incident on the oil abrasive particle detection area, generating a scattered beam that returns to the beam splitter along the original path; the transmitted beam is modulated by the phase modulation system to form a reference beam that returns to the beam splitter along the original path; the reference beam and the scattered beam interfere at the exit position of the beam splitter, forming an interference beam that is then incident on the detection system to obtain interference spectrum information; the amplitude and phase information of the cross-correlation term in the interference intensity expression are extracted from the interference spectrum information to construct a complex function of the interference beam signal, and then a Fourier transform is performed on the complex function to finally obtain a clear three-dimensional reconstructed image of lubricating oil abrasive particles.

A magnet (100, 300, 400) for a magnetic particle imaging device is provided with a pair of first DC coils (10), a pair of second DC coils (20), and a pair of AC coils (30). The pair of first DC coils are disposed facing each other in a first direction (DR1). The pair of second DC coils are disposed facing each other in a second direction (DR2) perpendicular to the first direction or in a third direction (DR3) perpendicular to the first direction and the second direction. The pair of AC coils is disposed facing each other in a first direction or a second direction. Each of the pair of second DC coils has a pair of first linear portions (22). Each of the pair of first linear portions extends in the same direction as the direction in which the pair of AC coils are disposed facing each other.

The application discloses a kind of irregular particle shape reconstruction methods based on phase recovery, builds interference particle imaging system;In defocus image plane obtains the defocus speckle image I of irregular particle to be measured M ; The defocus speckle image I M It is sheared, and the speckle region image I located in the center position and the size of N×N after shearing is retained;Speckle region image I is input into phase recovery algorithm model and iterative calculation is carried out, and preliminary reconstruction result is obtained;Proportion factor factor SF is set, and the preliminary reconstruction result of the above iteration, i.e. new particle estimate p k+1 (x0,y0) is scaled with proportion factor SF, and final reconstruction particle shape is obtained.Compared with prior art, the application can directly obtain accurate shape information of irregular particle through particle interference defocus image, without additional optical path setting, and the device is simple, which provides basis for the measurement of complex particle field.

The present invention belongs to the field of magnetic particle imaging, specifically to a generative reconstruction method for magnetic particle imaging based on physical priors. This method aims to address the issues of long matrix calibration time for magnetic particle imaging systems, reliance on model assumptions in mathematical modeling methods, and difficulty balancing acceleration performance and recovery accuracy in acceleration-based calibration methods, which in turn lead to low accuracy in reconstructed MPI images. The method comprises: constructing a system matrix containing physical priors; splitting the system matrix by column to obtain a set of system matrix columns as the original system matrix columns; inputting the original system matrix columns and various physical priors into a potential diffusion model based on physical priors for fine-tuning and training; inputting newly measured physical priors into the trained model to obtain generated system matrix columns, thereby forming a complete system matrix. The method then combines the measured signals to solve ill-conditioned equations and obtain an MPI image of the object to be measured. The present invention improves the accuracy of MPI image reconstruction while eliminating the need to calibrate the system matrix.

The present invention belongs to the field of magnetic particle imaging technology, and specifically relates to a magnetic particle imaging system and method based on a flexible receiving coil array, which aims to solve the problems of poor adaptability of current rigid receiving coils to biological surfaces and low signal-to-noise ratio for imaging tiny geometric textures. The present invention: Structurally, the receiving coil array is adhered to the surface of the object to be measured, and the compensation coil array is distributed on both sides of the flexible substrate. The receiving coil array is used to receive magnetic nanoparticle signals, and the block-type small compensation coil array is used to compensate for feedthrough interference and electromagnetic interference of the receiving coil; in terms of reconstruction method, the collected receiving signal is Fourier transformed in sequence, the in-phase third harmonic is extracted and superimposed to obtain the processed signal, interpolation is used to construct a sinusoidal diagram for the Cartesian coordinate distribution, and the filtered back projection method is used to reconstruct the three-dimensional particle concentration distribution of the object to be measured. The present invention adopts a flexible receiving coil array strategy and provides an adaptive reconstruction method, thereby improving the imaging signal-to-noise ratio.

The application discloses a kind of HPLC pipeline blockage detection system and method based on magnetic particle imaging, solve the problem that traditional indirect measurement mode relies on the experience and ability of instrument user, it is difficult to accurately identify the position and degree of blockage, low efficiency, easy to cause instrument damage.The HPLC pipeline blockage detection system and method based on magnetic particle imaging inject mobile phase containing magnetic nanoparticles into HPLC pipeline, open the flow pressure pump of HPLC to make liquid flow, then excite magnetic nanoparticles in the field-free point (FFP) of gradient field by alternating magnetic field, and use detection coil to induct the signal generated by magnetic nanoparticles, then transmit to data processing system, complete the detection of blockage position information in HPLC pipeline.The detection system and method realize real-time, non-destructive detection of HPLC pipeline blockage by the magnetic response characteristics of magnetic nanoparticles under the action of external magnetic field, can improve the accuracy and stability of analysis result, wide application range.

The application relates to the field of magnetic particle imaging, in particular to a magnetic nanoparticle imaging system based on a permanent magnet and electromagnet composite driving mode, which comprises a magnet device, a first electric rotating table, a second electric rotating table, a third electric rotating table and a sample feeding device, the first electric rotating table and the second electric rotating table are located on the two sides of the magnet device, the third electric rotating table is located on one side of the second electric rotating table, the magnet device comprises a permanent magnet and an electromagnet, the permanent magnet comprises a focusing field permanent magnet and two selection field permanent magnets, the two selection field permanent magnets are driven to rotate through the first electric rotating table and the second electric rotating table, the focusing field permanent magnet is driven to rotate through the third electric rotating table, the electromagnet part is located outside the permanent magnet part and does not rotate, and the sample feeding device is located in the cavity of the permanent magnet part and does not rotate. The permanent magnet and the electromagnet composite driving mode can effectively reduce the power consumption of the magnetic nanoparticle imaging system.

The application belongs to the field of magnetic particle imaging, and particularly relates to a rotating gradient magnetic particle imaging device and method based on cross-coil driving, aiming to solve the problems of difficulty in effective coding in the absence of a magnetic field region and low imaging sensitivity in magnetic particle imaging. The application comprises: superimposing the magnetic field generated by two pairs of mutually orthogonal cross-coil pairs and the uniform bias field through a magnetic field generation module to generate an imaging region magnetic field; changing the current direction of any one of the coil pairs in the cross-coil pair or changing the current type of the cross-coil pair to generate a rotating magnetic field under multiple rotating gradients through a gradient rotating module while the uniform bias field remains unchanged; obtaining scanning signals of each point in the imaging region under different magnetic fields through a scanning module; and generating the imaging result of the object to be measured based on the scanning signals under different magnetic fields through an imaging module. The application can realize high-sensitivity and reliable two-dimensional position coding MPI imaging without relying on the traditional magnetic field-free region.

The application discloses an aerodynamic lens sample injection device for single-particle imaging and belongs to the technical field of particle sample injection. The aerodynamic lens sample injection device comprises a gas removal device, a vacuum connection device and an aerodynamic lens. The gas removal device, the vacuum connection device and the aerodynamic lens are sequentially connected and communicated. The input end of the aerodynamic lens is used for receiving particles transmitted by the vacuum connection device, and the output end of the aerodynamic lens is used for conveying the focused particles to an experimental area. The output end of the aerodynamic lens is provided with an acceleration nozzle. The acceleration nozzle comprises a stepped nozzle and a converging capillary tube. The inner diameter of the stepped nozzle decreases in sequence along the particle conveying direction. One end of the converging capillary tube is a tapered port, and the other end is communicated with the inner cavity of the aerodynamic lens after penetrating through the stepped nozzle. Through cooperation between the above structures, the Brown motion of small particles is inhibited, the particle beam width is smaller, the gas flow is reduced, and the scattering of the gas background is reduced.

The invention belongs to the field of magnetic particle imaging, particularly relates to a rapid system matrix calibration algorithm applied to magnetic particle imaging, and aims to solve the problem that rapid system matrix calibration and high-resolution imaging cannot be considered at the same time in the prior art. The method comprises the following steps: acquiring a public data set, screening a high signal-to-noise ratio system matrix, converting the matrix into a three-dimensional cube format, and dividing the matrix into a training set and a test set according to scanning parameters; the method comprises the following steps: acquiring frequency domain response of a magnetic nanoparticle point-like phantom in a scanning / excitation magnetic field through actual measurement, and generating an actual measurement system matrix set through mobile sampling and frequency point screening; constructing a magnetic particle concentration distribution matrix, and generating a simulation system matrix set through numerical simulation and frequency point screening; constructing a deep learning model which comprises an image coding unit, a feature processing unit and an image reconstruction unit; and inputting the matrix to be calibrated into the trained model, and outputting the calibrated high-resolution system matrix. According to the method, the calibration efficiency is remarkably improved, and the imaging resolution is maintained.

This invention belongs to the field of magnetic particle imaging, specifically relating to a three-dimensional magnetic particle imaging system, method, and device that fuses imaging parameters for quantitative analysis. It aims to address the problem that existing technologies only focus on the quality analysis of two-dimensional MPI reconstructed images, using a single parameter and failing to comprehensively assess the combined influence of multiple factors on the reconstructed image, resulting in poor quality of the reconstructed MPI three-dimensional image. The system includes: an input module configured to acquire a phantom model of the object to be reconstructed, as well as the imaging parameters and interference parameters of the MPI imaging device; a signal calculation module configured to calculate the induced voltage signal; a reconstruction module configured to perform three-dimensional reconstruction of the object to be imaged based on the induced voltage signal using a three-dimensional image reconstruction method to obtain an MPI three-dimensional reconstructed image; and an output module configured to output the MPI three-dimensional reconstructed image. This invention improves the quality of MPI three-dimensional reconstructed images.

Described herein are methods and systems for imaging one or more particles flowing through a fluidic channel. The system includes a first light source optically coupled to a first beam resizing optical element, a second light source optically coupled to a second beam resizing optical element, and a data processing device for processing optical data from light scanners.

The present application belongs to the technical field of magnetic particle imaging, and particularly relates to an open magnetic particle imaging method and system based on magnetic field rotation coding, aiming to solve the problems of limited imaging resolution, insufficient imaging depth, excessive power consumption and the inability of MPS to image in the prior art single-sided MPI imaging. The present application: uses a bar-shaped permanent magnet or a coil to create a stable and controllable static magnetic field environment, drives the static magnetic field to rotate by means of a mechanical mechanism, changes the distribution form of the spatial static magnetic field and completes the coding operation, increases the number of independent equations to be solved, and then generates a system matrix, constructs a matrix equation capable of accurately solving the magnetic particle concentration distribution, solves the matrix equation, and successfully reconstructs the magnetic particle image of the target object. The present application is applied to a single-sided MPI device, effectively increases the imaging depth, improves the resolution and reduces the power consumption; and is applied to an MPS device, has imaging capability and expands the application range.

The present application belongs to the field of magnetic particle imaging, and particularly relates to a magnetic particle imaging image reconstruction method, system and device based on a max-min concave and total variation constraint, aiming to solve the problem of large error, poor precision and low quality of the MPI image reconstructed by the existing magnetic particle imaging image reconstruction method. The method comprises: acquiring a time domain voltage signal as an input signal; performing Fourier transform on the input signal and constructing a system matrix; based on the system matrix, constructing a mapping equation between the concentration of magnetic particle imaging and the input signal after Fourier transform as a first equation; combining isotropic total variation and max-min concave constraint to reconstruct the first equation to obtain a second equation; and iteratively solving the second equation by an alternating direction multiplier method with a mixed penalty function to obtain the concentration of magnetic particle imaging and perform image reconstruction. The present application reduces the error of the reconstructed MPI image, and improves the precision and quality of the reconstructed MPI image.

The invention belongs to the field of medical image reconstruction, particularly relates to a projection type magnetic particle imaging sparse view angle reconstruction method, system and equipment, and aims to solve the problem of insufficient accuracy of a sparse view angle reconstruction technology. The method comprises the following steps: acquiring three-dimensional projection data of a to-be-imaged target at a sampling projection angle; segmenting the three-dimensional projection data into a plurality of plane slices, and obtaining a space coordinate vector and a sampling projection angle of any plane slice; generating input data based on the neighborhood set of the sampling projection angle of each plane slice, the space coordinate vector and the sampling projection angle, and constructing a projection completion network by taking the magnetic particle concentration signal as output data; optimizing the projection completion network by obtaining an uncertainty index; generating a complementation projection based on the optimized projection complementation network; and performing back projection reconstruction on the complemented projection to obtain a reconstructed image of the to-be-imaged target. According to the invention, high-accuracy magnetic particle imaging can be realized through less data.

The application discloses an interference fringe pattern positioning method based on target detection. The application uses an interference particle imaging system to obtain an interference fringe pattern of a transparent spherical particle, divides the labeled interference fringe pattern into a training set, a verification set and a test set, obtains optimal weights after training for 200 epochs, takes the test set as input of a target detection network, obtains a prediction box containing normalized position information of the interference fringe pattern, and obtains a center point of the interference fringe pattern after coordinate extraction and inverse transformation. The application can realize high-precision positioning of the interference fringe pattern of the transparent spherical particle, and provides technical support for particle size measurement.

Multiple calibration methods for particle imaging apparatuses are proposed, which allow a lateral focal shift to be determined depending on a focusing setting change or a refocusing of a particle imaging apparatus Distortions in particle-optical images created by correspondingly calibrated particle imaging apparatuses can be reduced in this way, and metrological examinations in the particle-optical images and in particular in 3D tomographic images may be implemented with greater accuracy. Using correspondingly calibrated particle imaging apparatuses, it is possible in particular to measure 3D samples such as deep channels in semiconductor samples more accurately. It is also possible to calibrate and hence correct distortion effects that arise on account of sample geometries in electrostatic immersion fields.

The application belongs to the field of magnetic particle imaging, and particularly relates to a magnetic particle imaging method and device based on multi-source noise monitoring and collaborative compensation, aiming to solve the problem that magnetic particle signals are easily interfered by multi-source noise. The method comprises the following steps: during excitation or gradient field operation, a main receiving signal is collected, and multi-path noise monitoring signals are synchronously collected through at least two noise monitoring coils; the multi-path noise monitoring signals are input into a background noise prediction model to obtain predicted background noise, wherein the background noise prediction model is trained based on signals collected by the main receiving coil and the noise monitoring coil under the no-load state of a magnetic particle imaging device; the predicted background noise is eliminated from the main receiving signal to obtain a purified magnetic particle response signal; and a reconstructed image is generated based on the purified magnetic particle response signal. The application can obtain a high signal-to-noise ratio MPI response signal online, and improve the imaging speed and long-term stability without changing the existing scanning architecture.

The invention discloses a PIV test bed for testing an internal flow field of a stirring kettle and a calibration method, the PIV test bed comprises a stirring device, a camera assembly, a laser assembly and an external processor, the stirring device comprises the stirring kettle, and the invention further discloses a calibration method of the PIV test bed for testing the internal flow field of the stirring kettle. The camera corresponds to the stirring kettle according to shooting requirements, and horizontal calibration of the camera is achieved; the horizontal position of the laser generator is adjusted to enable the laser generator to correspond to the stirring kettle, and calibration of the laser generator is achieved. According to the invention, based on a laser plane automatic positioning technology of a CCD camera luminous flux signal, the imaging definition of the tracer particles is improved; based on the arrangement of the convex body light supplementing structure, the light scattering capability is enhanced, the shadow interference is reduced, and the calibration uniformity is improved; the calibration plate automatic adjusting mechanism based on the motor realizes high-precision displacement control, and ensures operation safety and measurement accuracy.

The application provides a kind of multi-block magnetic particle imaging method and system, which can be applied to medical image processing technical field.The method comprises the following steps: collecting a plurality of magnetic particle system matrices corresponding to a plurality of sub-imaging regions in the region to be imaged respectively; using a trained boundary prediction model to perform extrapolation on the plurality of magnetic particle system matrices to obtain a plurality of matrix extrapolated magnetic particle system matrices, the trained boundary prediction model being trained using simulation-generated magnetic particle system matrix samples and a loss function based on spatial continuity constraints and edge sparsity constraints; using the plurality of matrix extrapolated magnetic particle system matrices to perform image reconstruction on the plurality of sub-imaging regions to obtain a plurality of field-of-view expanded magnetic particle image blocks; performing cropping on the plurality of field-of-view expanded magnetic particle image blocks to obtain a plurality of boundary artifact-eliminated magnetic particle image blocks; and splicing the plurality of boundary artifact-eliminated magnetic particle image blocks to obtain a magnetic particle imaging result of the region to be imaged.