158 results about "Particle imaging" patented technology

The invention belongs to the technical field of magnetic particle imaging, relates to a magnetic particle imaging reconstruction method based on a calibration magnetic field generation system matrix, and aims to solve the problems that a traditional magnetic particle imaging reconstruction method is poor in applicability in asymmetric bilateral structure magnetic particle imaging equipment (A-MPI) and cannot perform imaging in any region. The method comprises the following steps: performing grid division on an imaging area, calibrating magnetic field intensity, and obtaining magnetic field gradient distribution of each point; obtaining a theoretical system matrix according to a mathematical calculation mode; randomly moving the positions of the non-magnetic field points for scanning to obtain actually measured magnetic field gradient distribution and a system matrix, and constructing a data set; expanding the data set based on the simulation system; constructing a deep learning model, and inputting the extended data set and the measured data into the training deep learning model; and inputting a theoretical system matrix at any position, and obtaining an accurate system matrix by using the trained model. According to the invention, the system matrix at any position can be obtained under the A-MPI equipment, so that imaging at any position is realized.

Provided in the present invention are an imaging device and method for turbid oil abrasive particles based on polarized image enhancement, which belong to the technical field of image processing. The imaging device of the present invention includes a CMOS fixing device, a Stokes polarized CMOS sensor, an optical lens sleeve and an optical magnifying glass, where the Stokes polarized CMOS sensor includes a CMOS sensor and a Stokes analyzer. By using a polarization characteristic difference between scattered light of lubricating oil media and reflected light of abrasive particles, Stokes vector information is measured in real time under turbid lubricating oil scenes, the scattered light of the media is filtered out, image quality of the abrasive particles is improved, coverage duration for monitoring abrasive particle imaging is effectively prolonged.

The invention provides a magnetic particle imaging resolution improving method and system based on frequency domain information filtering, and relates to the technical field of magnetic particle imaging. Comprising the following steps: inputting original magnetic particle imaging data into a Transform model, and selectively filtering frequency domain information in the magnetic particle imaging data through a fusion frequency domain discrimination feedforward network module in an encoder to obtain the output of the encoder; inputting the output of the encoder into a bottleneck layer, aggregating global and local information through a multi-scale attention mechanism module, and then selectively filtering frequency domain information in the magnetic particle imaging data again to obtain the output of the bottleneck layer; inputting the output of the bottleneck layer into a decoder with the same structure as the bottleneck layer to obtain deep features; inputting the deep features into a convolutional layer to obtain a residual image; and calculating the sum of the original magnetic particle imaging data and the residual image to obtain a reconstructed image. According to the invention, the overall imaging resolution of the MPI image under the low-gradient field acquisition condition is improved.

The invention belongs to the field of magnetic particle imaging, particularly relates to a magnetic particle high-resolution reconstruction method based on fast feature fusion, and aims to solve the problems that an existing magnetic particle reconstruction method is slow in system matrix calibration, low in reconstructed magnetic particle image resolution, limited in signal-to-noise ratio and the like. The method comprises the following steps: collecting a system matrix generated by using a standard particle sample as a low-resolution system matrix; acquiring a voltage signal of the to-be-imaged phantom; inputting the low-resolution system matrix into the trained fast feature fusion Transform model to obtain a high-resolution system matrix; and based on the voltage signal, reconstructing the high-resolution system matrix to obtain a high-resolution MPI image. According to the method, the resolution of the MPI image is improved by carrying out rapid super-division on the system matrix, tedious and time-consuming calibration in system matrix reconstruction is avoided, in addition, resolution and signal-to-noise ratio improvement can be carried out on any system matrix, and a scanning mode related to the system matrix is not needed.

The invention belongs to the technical field of magnetic particle imaging, particularly relates to a magnetic particle imaging system and method based on a flexible receiving coil array, and aims to solve the problems that an existing rigid receiving coil is poor in biological surface adaptability and low in signal-to-noise ratio for micro geometric texture imaging. According to the structure, a receiving coil array adheres to the surface of an object to be measured, the receiving coil array and a compensation coil array are distributed on the two sides of a flexible substrate, the receiving coil array is used for receiving magnetic nanoparticle signals, and the partitioned small compensation coil array is used for conducting feed-through interference and electromagnetic interference compensation on a receiving coil; the reconstruction method comprises the following steps: sequentially carrying out Fourier transform on the collected receiving signals, extracting in-phase third harmonics and superposing to obtain processed signals, interpolating to construct a sinogram for Cartesian coordinate distribution, and reconstructing the three-dimensional particle concentration distribution of a measured object by a filtering back projection method. A flexible receiving coil array strategy is adopted, an adaptive reconstruction method is provided, and the imaging signal-to-noise ratio is improved.

The invention belongs to the technical field of magnetic particle imaging, and relates to a magnetic particle imaging method based on mixed-frequency magnetic field excitation, which comprises the following steps: acquiring a dotted magnetic nanoparticle sample and a to-be-imaged object, respectively applying a mixed-frequency excitation magnetic field in an imaging mode to the dotted magnetic nanoparticle sample and the to-be-imaged object, acquiring a mixed frequency magnetic field excitation-based system matrix and a mixed frequency domain magnetization response frequency spectrum signal; and inputting the system matrix and the mixed frequency domain magnetization response frequency spectrum signal into a concentration spatial distribution inversion model to perform concentration spatial distribution inversion of the magnetic nanoparticles, obtaining the concentration spatial distribution of the magnetic nanoparticles in the object to be imaged, and performing magnetic particle concentration distribution imaging. According to the invention, real-time high-resolution magnetic particle imaging can be realized.

The invention discloses a directional grouting test device and a visual test method for a goaf, and the method comprises the steps: building a bed rock, laying a mineral product to be mined, laying and filling an area to be reinforced, burying a soil pressure gauge and a water pressure gauge, burying a grouting floral tube, arranging a grouting inner tube, communicating a grouting system, and setting a particle imaging velocimeter PIV. In the test process, the seepage and diffusion process in the slurry and the stress state of the rock-soil body are monitored by using a soil pressure meter and a water pressure meter; calculating the total amount of slurry flowing into the model through a slurry barrel outer scale; after grouting is finished, original-state sampling is conducted on the grouting permeation reinforcement area, a mechanical property test and a microcosmic test are conducted, and the grout permeation and reinforcement effect is analyzed; the grouting pressure-seepage distance-mechanical property relation is obtained. The goaf directional grouting permeation simulation device can carry out goaf directional grouting permeation simulation, facilitates mechanical property test of original state sampling, and has the characteristics of visualization, simulation, monitoring and the like.

The invention relates to a method for evaluating and debugging a sterile pipeline for food and beverage processing, which comprises the following steps of: introducing standardized sterile gas into a closed pipeline system to establish a micro-positive pressure environment; detecting a pressure change curve of each node of the system in real time by using a micro-differential pressure sensing module; calculating the position and the size of a trace leakage point; recording the motion trail of the particles in the pipeline by using a dynamic particle imaging system PIV; flow dead angles are identified through trajectory analysis, and the potential pollution accumulation area of the retention area marks the pollution accumulation probability of each section of pipeline in a quantitative mode; preparing simulation liquid, and adding biomarker particles to enable the viscosity and the fluidity of the target beverage to be close to those of the target beverage; according to the identified potential pollution accumulation area, local directional pouring is carried out; full-process automatic data acquisition, model judgment and debugging instruction issuing can be realized, manual intervention is greatly reduced, the system stability is improved, and the system is suitable for various food and beverage production scenes.

This invention discloses a particle morphology recognition method based on YOLOv7 and interferometric imaging technology. The method uses an interferometric particle imaging system to obtain interferometric defocused images of a mixed particle field to create a dataset. The annotated interferometric defocused images are divided into training, validation, and test sets. The network is then improved by incorporating a collaborative attention module to enhance detection accuracy. Hyperparameters are adjusted, and training and testing are performed using the annotated dataset. After 200 epochs of training, the optimal weights are obtained, ultimately achieving mixed particle field morphology recognition. This method can achieve high-precision identification of particle morphology in mixed particle fields, providing technical support for acquiring cloud particle field information.

The invention discloses a rock permeability testing system in a high-temperature and high-pressure environment and a using method thereof, and belongs to the technical field of geothermal development or coal in-situ gasification mining. The test system is composed of a stress loading system, a test kettle assembly and a magnetic particle imaging system. When in use, the stress loading system and the test kettle assembly provide conditions such as high temperature, high pressure, seepage fluid and the like for a test piece; and detecting the spatial distribution state of the nano magnetic induction particles added in the seepage fluid through a magnetic particle imaging system to observe the pore and crack distribution characteristics in the test piece or detecting the nano magnetic induction particles added in the pollutant solution to observe the pollutant migration condition. The test system is scientific in design, simple in structure and easy to operate and maintain, can monitor pore fracture distribution and pollutant migration conditions in the test piece in real time under high-temperature and high-pressure conditions, provides accurate dynamic observation data, and provides important technical support for reservoir assessment and optimization in a complex environment.

The invention belongs to the field of image reconstruction of magnetic particle imaging and multi-modal generative artificial intelligence models, particularly relates to a magnetic particle image reconstruction method and system based on a multi-modal diffusion model, and aims to solve the problem that there is no method capable of combining a generative model and a multi-modal imaging technology to realize accurate quantitative reconstruction of MPI. The method comprises the following steps: carrying out integral modeling and discretization operation on a first excitation signal to obtain discrete signals, fitting and superposing the discrete signals to obtain a first response signal, calculating a loss function, and training a model based on the loss function; processing the second time sequence signal by using the trained particle response model to obtain a second response signal; calculating based on the second response signal and the system matrix, gradually adding noise, and constraining to obtain a noise constrained image; and gradually denoising and recovering the noise constraint image in the last step to obtain a final reconstructed image. According to the invention, rapid and high-quality MPI image reconstruction becomes possible.

The invention discloses a multi-particle three-dimensional shape reconstruction method based on projection consistency. According to the method, a three-angle laser interference particle imaging system is used for collecting out-of-focus images of three visual angles, a center M * N pixel range is cut to obtain an out-of-focus speckle image, phase recovery algorithm reconstruction is carried out, a two-dimensional particle shape is obtained, a gray threshold value above 70 is set to be a target contour area, binarization segmentation is carried out, and a target contour image is obtained. And smoothing the target contour area. And carrying out three-dimensional space projection on contours of the four candidate results in Matlab, generating a three-dimensional structure in an intersection region, re-projecting the three-dimensional structure to each view angle, calculating an error S between a re-projected image and an original input projection, and selecting a final reconstruction result with the minimum S. According to the method, through systematic iterative optimization and an error evaluation mechanism, trivial fuzzy interference in a phase recovery process is effectively eliminated, and high-precision reconstruction of a multi-particle three-dimensional shape is realized.

The invention belongs to the field of biomedical imaging, particularly relates to a multicolor magnetic particle imaging method and system based on magnetic field free line projection decoding, and aims to solve the problems of low imaging efficiency and quality caused by the absence of a relaxation-based multicolor imaging method by using a magnetic field free line in the prior art. The method comprises the following steps: respectively placing N kinds of magnetic nanoparticles in an imaging view center for scanning, and obtaining a time-frequency spectrum center spectral line by adopting time-frequency analysis; scanning an imaging object, acquiring a voltage response signal and performing time-frequency analysis to obtain a time-frequency spectrum; a linear equation set is constructed and solved, and all unknown quantities are obtained; discretely rotating the free line of the magnetic field by P angles, and obtaining the content distribution of N magnetic nanoparticles at each angle; and constructing a sinogram of the N magnetic nanoparticles, performing back projection reconstruction to obtain multicolor images, and superposing the multicolor images to obtain a reconstructed image. According to the invention, relaxation-based multicolor imaging is realized by using the free line of the magnetic field, and the imaging efficiency and quality are improved.

Several calibration methods for particle imaging systems are proposed that allow the determination of lateral focus shifts as a function of focusing changes or refocusing. Distortions in particle-optical images generated with appropriately calibrated systems can thus be reduced, and metrological investigations in these images, and especially in 3D tomography, can be performed with greater accuracy. With appropriately calibrated particle imaging systems, 3D samples, such as deep channels in semiconductor samples, can be measured more precisely. Distortion effects arising from sample geometries in electrostatic immersion fields can also be calibrated and thus corrected.

The invention provides a dynamic self-adaptive range compensator imaging system, which belongs to the technical field of particle imaging equipment, and comprises a particle track detection module used for screening particles directly penetrating through a detector, reconstructing the track and direction of particle motion, and obtaining the energy and position information when particles are incident; the self-adaptive range compensation module is used for realizing dynamic self-adaptive compensation of the particle residual range by adjusting the effective thickness of the compensator so as to receive the particle signal and obtain the residual range corresponding to the residual energy when the particle penetrates out of the imaged object; wherein the effective thickness of the compensator refers to the thickness of the compensator in the particle incidence range along the particle incidence direction; and the image processing module is used for calculating and outputting an image according to the residual range of the imaged object under the conditions of different positions and angles. Through the dynamic compensator, (quasi) continuous range compensation is realized, the precision is improved, and a better detection effect is realized while the cost is reduced.

The invention relates to the technical field of medical imaging, in particular to a narrowband-based multi-harmonic magnetic particle imaging method, which comprises the following steps of: determining a magnetic particle imaging area, and acquiring a first area and a second area according to the magnetic particle imaging area; placing a magnetic nanoparticle sample in the first area, externally applying a magnetic field, and extracting harmonic signals to construct a system matrix; placing a measured object in the second area and externally applying a magnetic field, and extracting harmonic signals to construct a harmonic signal matrix of the measured object; and according to the system matrix and the harmonic signal matrix of the measured object, constructing an equation to be solved and carrying out inversion solution to obtain an image of magnetic nanoparticle concentration distribution. Compared with a broadband imaging technology, the narrow-band imaging technology is adopted, the requirement for the bandwidth of a magnetic particle imaging system is lowered, and the problem of insufficient bandwidth under high-frequency excitation is solved.

The invention discloses a method for measuring the molar concentration of nano-particles. The method comprises the following steps: diluting a nano-particle suspension with a high-molecular polymer solution or dispersing nano-particle powder into the high-molecular polymer solution; transferring the suspension liquid to a spacing net on the side of a sample pool in an electrophoresis tank; nano-particles migrate from the sample pool to the buffer pool under the driving of the electric field and are uniformly distributed on the spacing net in a single-particle manner; performing single-particle imaging on the spacing net by using an optical microscope; and counting the number of the nanoparticles in the image so as to measure the molar concentration of the nanoparticles in the sample. The method can be used under the condition that the properties of the nanoparticles are unknown or no standard substance exists, the detection object has no additional condition, and the accuracy is high.

The invention belongs to the field of magnetic particle imaging, particularly relates to a three-dimensional magnetic particle imaging enhancement method and system based on distillation structure contrast learning, and aims to solve the problems of anisotropic resolution and background noise interference caused by sparse scanning tracks in three-dimensional magnetic particle imaging. The method comprises the following steps: constructing a data set; building a two-dimensional isotropic teacher network model and a three-dimensional resolution improvement student network model; training a two-dimensional isotropic teacher network model and storing model parameters; the three-dimensional resolution improvement student network model obtains model parameters and then carries out training, an obtained three-dimensional training result is converted into two-dimensional training input data, and the two-dimensional training input data is input into the two-dimensional isotropic teacher network model to generate a supervision benchmark which is used for updating and optimizing the three-dimensional resolution improvement student network model; and after training, carrying out resolution improvement processing on the input three-dimensional magnetic particle imaging image. According to the method, the isotropic resolution of the three-dimensional magnetic particle image is improved, and background noise is effectively suppressed.

The invention belongs to the technical field of magnetic particle imaging, relates to a magnetic particle imaging reconstruction method based on multi-angle Cartesian scanning adaptive optimization, and aims to solve the problems of easy information redundancy, low resolution and insufficient response signal representation under the condition of low gradient in free point scanning in the existing imaging technology. The method comprises the following steps: setting magnetic field generation related parameters and a measurement mode of a rotating Cartesian angle scanning track of a magnetic field free point; constructing a system function harmonic diagram under each rotation angle; constructing a system matrix under each rotation angle, analyzing the system matrix under each angle and the weight and contribution of each frequency component in the system matrix, and determining an optimal system matrix; constructing an observation vector sequence; and reconstructing a magnetic particle image. According to the method, image reconstruction is carried out through the Cartesian scanning track of the free point of the rotating magnetic field and the weighted multi-angle system matrix, the system matrix and particle response representation under the low gradient are enriched, and the imaging resolution is improved.

The present application relates to the field of magnetic particle imaging, and particularly relates to a kind of fast calibration method and system of MPI system matrix based on multi-stage wavelet transform and double branch attention network, to solve the problem of time-consuming, complex of existing calibration-based system matrix acquisition method.The method of the present application comprises: obtaining a low-resolution system matrix according to a pre-set undersampling grid;The system matrix is encoded by row RGB to obtain an RGB image;The above-mentioned RGB image is input into the trained MWaveDAN network model to obtain a high-resolution RGB image;The high-resolution RGB image is decoded into complex form to obtain a complex-based system matrix.The present application effectively accelerates the high-resolution acquisition of system matrix in MPI, and provides important support for the future development of MPI technology.

The invention relates to the technical field of magnetic particle imaging, in particular to a core-shell nanoprobe and a preparation method and application thereof.The core-shell nanoprobe comprises a magnetic core and a nanoshell which is located outside the magnetic core and has a magnetic shielding response function, and the structure of the nanoshell collapses under the tumor microenvironment condition; the saturation magnetization of the magnetic core is greater than or equal to 50 emu / g, and the coercive force is less than or equal to 5 Oe; the saturation magnetization of the nano shell is less than 50 emu / g, and the coercive force is more than 5 Oe. According to the core-shell nanoprobe, through a unique magnetic core-shell structure design and tumor microenvironment response characteristics, a magnetic shielding layer is formed by using a low-signal nano shell with a response magnetic shielding function, and background signal interference is inhibited. In a tumor microenvironment, the shell structure of the core-shell nanoprobe collapses, the magnetic core is exposed, and a high magnetic signal is released and generated, so that the imaging signal-to-noise ratio is remarkably improved. According to the invention, the bottleneck that the traditional MPI probe is lighted in the whole course can be broken through, the tumor specificity is lighted and positioned, and the problems that the external background of the tumor is high, the contrast ratio is poor, and tiny focuses are difficult to detect are solved.

The present invention belongs to the technical field of medical imaging detection, and particularly relates to a method for rapid calibration of a matrix of a magnetic particle imaging system, including: performing spatial discretization on an imaging region and setting magnetic particle imaging magnetic field configuration parameters; obtaining magnetic particle magnetization response spectrum information at different spatial positions of field-free points; obtaining magnetic particle magnetization response spectrum information at different magnetic particle spatial positions based on the principle of equivalent substitution; calculating and assembling to obtain a matrix of the magnetic particle imaging system. According to the symmetry of the magnetic particle imaging gradient magnetic field, the present invention uses the movement of the spatial position of the field-free point to replace the mechanical movement of the magnetic particle spatial position, realizes the rapid calibration of the matrix of the magnetic particle imaging system, and significantly shortens the calibration time.

The utility model relates to the technical field of multiphase flow measurement, and discloses a multiphase flow microscopic imaging measurement system based on a particle imaging technology, which comprises a multiphase flow injection system, a microscopic chip, a waste collection system, an optical system, an image acquisition system and an image processing system, the optical system is arranged below the microchip, the image acquisition system is arranged above the microchip, and the image processing system is connected with the image acquisition system. According to the utility model, through illumination of the optical system, multi-channel synchronous control of the microcosmic chip and shooting of the accurate image acquisition system, high-resolution nano particle images can be obtained, and the system is suitable for accurate measurement and analysis of multiphase flow in scientific research and industrial application, and has the advantages of high precision and high efficiency.

The present invention belongs to the field of magnetic particle imaging, and specifically relates to a zero-inertia magnetic focusing ring magnetic particle imaging system and method without magnetic field lines, aiming to solve the problems of low magnetic field gradient, high complexity of magnetic field control, and limited imaging space. The present invention includes: the current of the gradient magnetic field coil group is generated by the magnetic field control and imaging module, output through the signal acquisition and output module, and amplified by the gradient power amplifier module. The current of the axial excitation magnetic field coil is generated by the magnetic field control and imaging module, output through the signal acquisition and output module, and amplified by the excitation power amplifier module. The signals received by the multi-axis detection coil are filtered and amplified by the signal processing unit, and then input to the imaging module by the magnetic field control and imaging module for algorithm reconstruction. The present invention not only significantly improves the magnetic field gradient and control accuracy, but also realizes the imaging space of the axial cross-section.

The invention discloses a magnetic particle imaging method based on multi-harmonic energy-full width at half maximum combined weighting, which comprises the following steps: acquiring point spread functions of a plurality of harmonic waves with different frequencies of magnetic nanoparticles, and constructing a corresponding system matrix; measuring a reference sample which does not contain the magnetic nanoparticles, and obtaining a plurality of noise matrixes corresponding to harmonic waves with different frequencies; measuring the sample to be measured, and obtaining magnetization response voltage vectors of a plurality of harmonic waves with different frequencies; respectively calculating an energy two-norm of a system matrix, an energy two-norm of a noise matrix and a full width at half maximum of a point spread function of the system matrix and the noise matrix; splicing the magnetization response voltage signals of each harmonic system matrix to form a total system matrix and a total measurement signal vector; calculating a weight factor of each harmonic wave and forming a weight matrix; and constructing a solution equation of the particle concentration distribution of the sample to be detected, and carrying out iterative solution on the solution equation to obtain a particle concentration distribution image of the sample to be detected. According to the invention, efficient utilization of multi-harmonic information is realized.

Disclosed is an imaging apparatus comprising: a segmented scintillator structure; and a photocathode structure optically coupled to the segmented scintillator structure, for conversion of high-energy particles with an arbitrary spatial distribution to a corresponding distribution of photoelectrons, emitted with a spread in energy ranging from 100 meV to 1 meV. Also disclosed is an imaging apparatus comprising: a segmented scintillator structure, and a photocathode structure optically coupled to the segmented scintillator structure, for conversion of high-energy particles with an arbitrary spatial distribution to a corresponding distribution of photoelectrons, emitted with an angular spread ranging from 10 degrees to 0.1 degrees. Also disclosed is a pressureless filling of capillary tubes and nano-molds using electroosmosis effect.

This invention provides a three-dimensional detection system for lubricating oil abrasive particles based on a phase-shifting micromirror, comprising: a light source system, a beam splitter, an abrasive particle imaging system, a phase modulation system, and a detection system; the light source system emits a parallel beam that is incident on the beam splitter; the beam splitter divides the parallel beam into two identical transmitted beams and reflected beams; the reflected beam passes through the abrasive particle imaging system and is incident on the oil abrasive particle detection area, generating a scattered beam that returns to the beam splitter along the original path; the transmitted beam is modulated by the phase modulation system to form a reference beam that returns to the beam splitter along the original path; the reference beam and the scattered beam interfere at the exit position of the beam splitter, forming an interference beam that is then incident on the detection system to obtain interference spectrum information; the amplitude and phase information of the cross-correlation term in the interference intensity expression are extracted from the interference spectrum information to construct a complex function of the interference beam signal, and then a Fourier transform is performed on the complex function to finally obtain a clear three-dimensional reconstructed image of lubricating oil abrasive particles.

A magnet (100, 300, 400) for a magnetic particle imaging device is provided with a pair of first DC coils (10), a pair of second DC coils (20), and a pair of AC coils (30). The pair of first DC coils are disposed facing each other in a first direction (DR1). The pair of second DC coils are disposed facing each other in a second direction (DR2) perpendicular to the first direction or in a third direction (DR3) perpendicular to the first direction and the second direction. The pair of AC coils is disposed facing each other in a first direction or a second direction. Each of the pair of second DC coils has a pair of first linear portions (22). Each of the pair of first linear portions extends in the same direction as the direction in which the pair of AC coils are disposed facing each other.

The application discloses a kind of irregular particle shape reconstruction methods based on phase recovery, builds interference particle imaging system;In defocus image plane obtains the defocus speckle image I of irregular particle to be measured M ; The defocus speckle image I M It is sheared, and the speckle region image I located in the center position and the size of N×N after shearing is retained;Speckle region image I is input into phase recovery algorithm model and iterative calculation is carried out, and preliminary reconstruction result is obtained;Proportion factor factor SF is set, and the preliminary reconstruction result of the above iteration, i.e. new particle estimate p k+1 (x0,y0) is scaled with proportion factor SF, and final reconstruction particle shape is obtained.Compared with prior art, the application can directly obtain accurate shape information of irregular particle through particle interference defocus image, without additional optical path setting, and the device is simple, which provides basis for the measurement of complex particle field.

The present invention belongs to the field of magnetic particle imaging, specifically to a generative reconstruction method for magnetic particle imaging based on physical priors. This method aims to address the issues of long matrix calibration time for magnetic particle imaging systems, reliance on model assumptions in mathematical modeling methods, and difficulty balancing acceleration performance and recovery accuracy in acceleration-based calibration methods, which in turn lead to low accuracy in reconstructed MPI images. The method comprises: constructing a system matrix containing physical priors; splitting the system matrix by column to obtain a set of system matrix columns as the original system matrix columns; inputting the original system matrix columns and various physical priors into a potential diffusion model based on physical priors for fine-tuning and training; inputting newly measured physical priors into the trained model to obtain generated system matrix columns, thereby forming a complete system matrix. The method then combines the measured signals to solve ill-conditioned equations and obtain an MPI image of the object to be measured. The present invention improves the accuracy of MPI image reconstruction while eliminating the need to calibrate the system matrix.