The invention discloses a lead-based neutron multiplier suitable for a fusion reactor solid cladding, which adopts a composite sphere design of a three-layer core-shell structure: a PbxMy sphere core material is a lead-based intermetallic compound with high melting point and excellent neutron multiplication performance, including but not limited to LaPb3, CePb3, Zr5Pb4, Zr5Pb3, PrPb3, NbPb3, Nd5Pb4, Nd5Pb3 and PbS, and plays a role in neutron multiplication; the middle shell layer is a PbxMy-Li2O metal ceramic composite material, the comprehensive tritium breeding ratio of the cladding is improved through efficient tritium production of Li2O and fusion neutrons, meanwhile, the metal ceramic composite material and a PbxMy metal interface have good thermodynamic matching, and the overall core-shell structure is stable; and the PbxMy shell layer is a thin film, so that the overall chemical inertness of the spherical shell is ensured. The invention provides a neutron multiplier design which is good in economical efficiency and can meet the fusion reactor tritium breeding requirement, and a feasible solution can be provided for replacing pure beryllium.