The present invention relates to gums, lozenges, candies, tablets, liquids and spray compositions that contain orally administered medications and dietary supplements that are released in the
oral cavity. The medications and dietary supplements contained therein may be delivered in a multi-phase mode. The compositions may also contain buffer systems that facilitate oral absorption. A rapid release is followed by slower release of medicant(s) and dietary supplements. The buffer
system is released simultaneously with the medicant(s) and dietary supplements, thereby facilitating transmucosal and buccal absorption of
active ingredient(s). The invention delivers, first, rapidly an initial pharmacologically effective
dose of
medicine and dietary supplements and, second, a prolonged pharmacologically sufficient
dose for longer-term relief of symptoms or provision of
therapeutic effect.