The present invention relates to gums, lozenges, candies, tablets, liquids and spray compositions that contain orally administered medications and dietary supplements that are released in the 
oral cavity. The medications and dietary supplements contained therein may be delivered in a multi-phase mode. The compositions may also contain buffer systems that facilitate oral absorption. A rapid release is followed by slower release of medicant(s) and dietary supplements. The buffer 
system is released simultaneously with the medicant(s) and dietary supplements, thereby facilitating transmucosal and buccal absorption of 
active ingredient(s). The invention delivers, first, rapidly an initial pharmacologically effective 
dose of 
medicine and dietary supplements and, second, a prolonged pharmacologically sufficient 
dose for longer-term relief of symptoms or provision of 
therapeutic effect.