The invention discloses a preparation method of high-purity 2-(diethylamino)
acetamide, which comprises the following steps: S1, carrying out amine
nucleophilic substitution reaction on methyl chloroacetate and
diethylamine in an alkaline environment to obtain 2-diethylamino
methyl acetate; s2, carrying out amine
esterification reaction on methyl 2-diethylaminoacetate and
ammonia water in the presence of a catalyst, extracting with an
organic solvent after the reaction is finished, and separating to obtain an organic phase containing 2-diethylaminoacetamide; s3, washing the organic phase with water, and then concentrating to recover the
organic solvent, so as to obtain a concentrated residue; s4, carrying out high-vacuum rectification on the concentrated residues, so as to obtain white
solid 2-diethylaminoacetamide; according to the present invention, the cheap and easily available raw materials are adopted, the three-step reaction
route is short, the operation condition is mild, the catalyst and the
ammonia are supplemented to the water phase after the amine
esterification reaction, and then the water phase is recycled, such that the generation of the high
ammonia nitrogen wastewater is effectively reduced, and the prepared 2-(diethylamino)
acetamide has characteristics of high purity and good yield.