10 results about "Vicinal" patented technology

The present application relates to a kind of preparation method of vicinal diol compound, which comprises the following steps: in non-aqueous solvent, formula (I) compound and reducing agent are reacted under light condition, to obtain the vicinal diol compound shown in formula (II);The reducing agent is formic acid or formate;The wavelength of the light is less than 390nm;Its reaction formula is as follows.The preparation method of the present application does not need transition metal catalyst, also does not need other special catalyst and special additive, and the aldehyde ketone substrate can be reacted with formic acid or formate in solvent by specific wavelength of light, to obtain corresponding vicinal diol compound with high yield, its reaction condition is mild, has wide substrate applicability, and green and environmental protection, simple and practical operation method, provides an effective synthesis strategy for the synthesis of shikimic alcohol compound.

The application belongs to the technical field of compound preparation, and discloses a preparation method of (1'S, 2'S)-eugenol glycerol 3'-O-beta-D-glucopyranoside. The method is characterized in that: a phenolic hydroxyl group allyl compound protected by a benzyl group is subjected to O-glycosylation reaction with a D-glucopyranosyl donor protected by an acetyl group, so as to obtain an olefin type protected glycoside intermediate which retains a side chain carbon-carbon double bond; then, asymmetric dihydroxylation reaction is performed on the intermediate, so as to construct a target vicinal diol chiral structure; finally, the acetyl protecting group of the sugar hydroxyl group and the benzyl protecting group of the phenolic hydroxyl group are sequentially removed, so as to obtain the target compound. The preparation method of (1'S, 2'S)-eugenol glycerol 3'-O-beta-D-glucopyranoside is characterized in that: the glycoside bond is constructed before dihydroxylation, which is beneficial to reducing the competition reaction of multiple hydroxyl groups and realizing the preparation of the target compound.

The invention relates to the technical field of magnetic resonance spectrum detection, in particular to a < 19 > F labeled probe as well as a preparation method and application thereof. The chemical structural formula of the < 19 > F-labeled probe is shown in the specification, and X is halogen. The probe designed by the invention can be used for simultaneous identification of vicinal diol / phenolic substances. The boric acid group in the probe has relatively strong affinity with vicinal diol / phenolic substances, and can be subjected to specific chemical reaction to generate boric acid ester and cause the change of 19F formant, so that simultaneous detection of vicinal diol / phenolic substances is realized. The ortho-position fluorine atom and the meta-position fluorine atom in the probe structure are sensitive to changes of the space structure and the electron cloud density respectively, identification and distinguishing of a series of vicinal diol / phenol substances are improved, and the problem that due to serious overlapping of formants of endogenous substances of MRS, signal identification becomes very difficult is solved.

The present invention belongs to the technical field of vicinal diol compound preparation, and in particular to a titanium silicon catalytic material and its preparation method and application. The preparation method comprises the following steps: S1, a mixture of a silicon source, a titanium source, a structure directing agent, a monosaccharide compound, and water is hydrolyzed and dispersed to obtain a mixed system I; S2, the mixed system I is added to a concentration kettle, and the water-silicon ratio of the mixed system I is reduced by distillation and dehydration to obtain a mixed system II; S3, the mixed system II is transferred to a closed crystallization kettle, and is hydrothermally reacted under autogenous pressure to obtain titanium silicon molecular sieve TS-1; S4, a mixture of a silicon source, a titanium source, an alkali source and water is hydrolyzed and dispersed to obtain an amorphous titanium silica gel precursor; S5, an amorphous titanium silica gel precursor, titanium silicon molecular sieve TS-1 and sesbania powder are mixed, and the titanium silicon catalytic material is obtained by kneading, forming, drying and roasting. The titanium silicon catalytic material obtained by the present invention is a heterogeneous catalytic material with a double Lewis active center, which can be used for one-step catalytic olefin preparation of vicinal diol compounds.

A fluorine containing silane compound represented by the following formula (1): (Rf1)α1—XA—(RSi)α2 . . . (1), wherein Rf1 is each independently a group having CF3 at an end, provided that CF3 at the end does not have CF2 at a vicinal position, XA is each independently a single bond, an oxygen atom, or a di- to decavalent organic group, RSi is a monovalent group containing a Si atom to which a hydroxyl group or a hydrolyzable group is bonded, α1 is an integer of 1 to 9, and α2 is an integer of 1 to 9.

The present invention provides a class of chain polyene vicinal diol compounds and their preparation methods and uses. The inventors obtained compounds Aspertrienediols A and B by separating and purifying the liquid fermentation extract of Antarctic Aspergillus sp.SCSIO 05702. Structural analysis showed that compounds 1 and 2 were both new compounds, and their specific structures were shown in formula (I). Through the evaluation of the anti-inflammatory activity of compounds 1 and 2, it was found that the new compound Aspertrienediol B (2) had a significant inhibitory effect on nitric oxide produced by mouse macrophage cell line RAW264.7 induced by lipopolysaccharide (LPS), and simultaneously inhibited the mRNA expression of pro-inflammatory factors such as MCP-1, IL-6 and TNF-α. At the same concentration, it had no cytotoxic activity on RAW264.7 cells, and could be used as a lead compound for the development of anti-inflammatory drugs.

This invention discloses a method for the photosynthesis of vicinal dihalogenated compounds using non-corrosive inorganic halide salts under photoactive conditions. The method comprises: directly converting aromatic olefin compounds into vicinal dihalogenated compounds R-X2 using metal halide salts under light irradiation, where R is an aromatic olefin compound and X is any one of F, Cl, Br, and I. This invention uses inexpensive and safe inorganic halide salts as the halogen source and reacts at room temperature and pressure, eliminating the need for additional photocatalysts, halogen elements, and oxidants. It exhibits high selectivity, is environmentally friendly, and can replace existing vicinal dihalogenated compound synthesis reaction systems, making it suitable for large-scale production.

In some aspects, the present disclosure provides polyiodinated polyamino compounds that comprise a residue of a carboxylic-acid-substituted polyamino compound that is linked to a residue of a polyiodinated aromatic compound that comprises a plurality of vicinal diol groups, each having a proximal hydroxyl group and a distal hydroxyl group, wherein the polyiodinated polyamino compound is formed by a process that comprises reacting a single carboxylic acid group of the carboxylic-acid-substituted polyamino compound in an ester coupling reaction with a single hydroxyl group selected from the proximal and distal hydroxyl groups of the plurality of vicinal diol groups of the polyiodinated aromatic compound, thereby forming an ester group that links the residue of the carboxylic-acid-substituted polyamino compound to the residue of the polyiodinated aromatic compound. Other aspects of the present disclosure pertain to methods of making such polyiodinated polyamino compounds and systems employing such polyiodinated polyamino compounds.

A first aspect of the invention relates to a purification process for obtaining vicinal toluenediamine. In a second aspect, the invention is directed to vicinal TDA (vTDA) obtained or obtainable from a process of the first aspect of the invention, comprising less than 100 weight-ppm of a toluidine compound of formula (I). A third aspect of the invention is related to vicinal TDA (vTDA) having a purity in the range of at least 99 weight- % and comprising less than 100 weight-ppm of a toluidine compound of formula (I).

Carbon dioxide foam treatment fluid comprising: a plurality of functionalized silanol-group silica nanoparticles the silanol group selected from the group consisting of an isolated silanol group, a vicinal silanol group, a geminaol silanol group, and any combination thereof; wherein the plurality of functionalized silanol group silica nanoparticles comprise crystalline silica; and a surfactant having a hydrophilic-lipophilic balance (HLB) value of 8 to 18.