36 results about "Vicinal" patented technology

A III–V nitride, e.g., GaN, substrate including a (0001) surface offcut from the <0001> direction predominantly toward a direction selected from the group consisting of <10-10> and <11-20> directions, at an offcut angle in a range that is from about 0.2 to about 10 degrees, wherein the surface has a RMS roughness measured by 50×50 μm2 AFM scan that is less than 1 nm, and a dislocation density that is less than 3E6 cm−2. The substrate may be formed by offcut slicing of a corresponding boule or wafer blank, by offcut lapping or growth of the substrate body on a corresponding vicinal heteroepitaxial substrate, e.g., of offcut sapphire. The substrate is usefully employed for homoepitaxial deposition in the fabrication of III–V nitride-based microelectronic and opto-electronic devices.

Disclosed is a compound represented by Structural Formula (I): Ar is a substituted or unsubstituted aromatic group. Q is a covalent bond, —CH2— or —CH2CH2—; W is a substituted or unsubstituted alkylene or a substituted or unsubstituted heteroalkylene linking group from two to ten atoms in length, preferably from two to seven atoms in length. Phenyl Ring A is optionally substituted with up to four substituents in addition to R1 and W, R1 is (CH2)n—CH(OR2)—(CH2)mE1, —(CH)═C(OR2)—(CH2)mE, —(CH2)n—CH(Y)—(CH2)mE or (CH)═C(Y)—(CH2)mE; wherein E is COOR3, C1–C3 alkylnitrile, carboxamide, sulfonamide, acylsulfonamide or tetrazole and wherein sulfonamide, acylsulfonamide and tetrazole are optionally substituted with one or more substituents independently selected from: C1–C6 alkyl, haloalkyl and aryl-C0-4-alkyl; R2 is H, an aliphatic group, a substituted aliphatic group, haloalkyl, an aromatic group, a substituted aromatic group, —COR4, —COOR4, —CONR5R6, —C(S)R4, —C(S)OR4 or C(S)NR5R6, R3 is H, an aliphatic group, a substituted aliphatic group, an aromatic group or a substituted aromatic group. Y is O—, CH2—, —CH2CH2— or CH═CH— and is bonded to a carbon atom in Phenyl Ring A that is ortho to R1. R4–R6 are independently H, an aliphatic group, a substituted aliphatic group, an aromatic group or a substituted aromatic group. n and m are independently 0, 1 or 2

The invention provides an application of rubiaceous cyclopeptide RA-V (1) as a Hippo-YAP signal pathway inhibitor, a preparation method of the rubiaceous cyclopeptide and an application of the rubiaceous cyclopeptide to preparation of drugs for treating and preventing YAP abnormal activation related cancers. The rubiaceous cyclopeptide provided by the invention is formed by condensation of peptide bonds of one alpha-D-alanine, one alpha-L-alanine, three substituted N-methyl-alpha-L-tyrosine and one alpha-L-amino acid of other types, and six amino acids are condensed to form an eighteen-membered ring, wherein a benzene ring between two vicinal tyrosines is connected through an oxygen bridge to form a fourteen-membered ring. Compared with the prior art, the preparation method provided by the invention can be used for rapidly separating and purifying the target compound RA-V (1) and has the advantages of high efficiency, strong purposiveness, few separation step, convenience in operation, good controllability and repeatability, recyclable solvent, low cost and suitability for industrial production.

The present invention relates to a multifunctional reusable catalyst and to a process for the preparation thereof on a single matrix of the support to perform multicomponent reaction in a single pot. The multifunctional catalysts of the invention are useful for the synthesis of chiral vicinal diols by tandem and / or simultaneous reactions involving Heck coupling, N-oxidation and AD reaction of olefins in presence of cinchona alkaloid compounds both as an native one and immobilized one in the said matrix support. This invention also relates to a process for preparing vicinal diols by asymmetric dihydroxylation of olefins in presence of cinchona alkaloid compounds employing reusable multifunctional catalysts as heterogeneous catalysts in place of soluble osmium catalysts.

The invention relates to a method for producing derivatives of O-α-glucosylated flavonoid, comprising at least one step of incubating a glucansucrase with a flavonoid and at least one sucrose, the flavonoid being a flavonoid which is monohydroxylated or hydroxylated in a non-vicinal manner on the B cycle. The invention also relates to novel O-α-glucosylated flavonoid derivatives, and to the use thereof.

A process for the purification of a tetraol PFPE derivative [tetraol (T)] of formula (I): HO—CH2—CH(OH)—CH2—O—CH2—CF2—O—Rf—CF2—CH2O—CH2—CH(OH)—CH2OH, wherein Rf represents a fluoropolyoxyalkene chain (chain Rf), from a mixture (M) of hydroxyl (per)fluoropolyether derivatives, said mixture comprising said tetraol (T) and at least one hydroxyl (per)fluoropolyether [PFPE (OH)] comprising a chain Rf terminated with at least one end group of formula: —CF2CH2OH; —CF2CH2O—CH(OH)—CH2—O—CH2—CH(OH)—CH2OH; said process comprising: step 1: reacting the mixture (M) with ketones and / or aldehydes so as to selectively protect couples of hydroxyl groups on vicinal carbon atoms by forming corresponding cyclic ketal / acetal derivatives, so as to yield a protected mixture (P); step 2: reacting residual hydroxyl groups of the mixture (P) with suitable functionalizing agents enabling substantial volatility modification, so as to obtain a functionalized protected mixture (Pf); step 3: fractional distillation of the mixture (Pf) so as to isolate the cyclic acetal / ketal derivatives of tetraol (T); and step 4: hydrolyzing the acetal / ketal derivatives of tetraol (T) so as to recover pure tetraol (T).

The invention relates to the food and medical industries, medical cosmetics, dermatology, agriculture and the mixed feed industry. According to the invention vicinal dithioglycole (common formula RCH(SH)CH(SH)R−1 (I)) is used as a food additive, a food product, physiologically-active substances and active ingredients of forage additives and of forage, in cosmetic and / or dermatological and skin-therapeutic remedies. The invention comprises methods for producing such additives, products and remedies. The substance of formula (I) stimulates physiological processes, increases human and animal immunity, inhibits undesirable process in organisms and food products, produces curative and preventive action of skin, hair and nails and after vicinal dithioglycole is administered the intoxication effect of alcohol consumption known as hang-over is completely remored.

The invention discloses a vicinal diol functionalized macroporous through-hole material as well as a preparation method and boric acid adsorption application thereof. The preparation method comprisesthe following steps: (1) adding an anionic surfactant into a polyethyleneimine aqueous solution; (2) adding microcrystalline cellulose into the system as a supporting material, and oscillating at a high speed for several minutes to form an air-in-water emulsion; (3) adding a cross-linking agent into the air-in-water emulsion, and oscillating at a high speed for several minutes to partially cross-link polyethyleneimine to cure the emulsion to form a block material; (4) forming a through-hole material through vacuum dehydration, wherein the microcrystalline cellulose can prevent the porous material from overall great shrinkage in the dehydration process, but local microscopic shrinkage still occurs, so that a porous through-hole structure is formed, and the anionic surfactant adsorbed on thesurface of holes is removed through alkaline washing; and (5) converting amino hydrogen on the surface of the porous material into vicinal diol functional groups through glycidyl ether treatment. Thevicinal diol functionalized macroporous through-hole material has the characteristics of simplicity and convenience in preparation, large adsorption capacity, mild regeneration conditions, repeated regeneration and no powder falling.

The invention relates to A 1-(biphenyl-4-ylmethyl)imidazolidine-2,4-dione derivative having the general Formula Iwherein R1 is H, (C1-6)alkyl (optionally substituted with oxo, OR4, COOR5, halogen or CN), (C2-6)alkenyl, (C2-6)alkynyl, (C3-6)cycloalkyl or (C3-6)cycloalkyl(C1-3)alkyl; R2 and R2′ are independently H or (C1-3)alkyl; or R2 and R2′ form together with the carbon atom to which they are bound a (C3-5)cycloalkyl group; R3 represents H or 1 to 4 F substituents; Y representsor NR8R9; X represents CHR6, CF2, O, S, SO or SO2; R4 and R5 are (C1-6)alkyl; R6 is H, OR7 or CN; R7 is (C1-3)alkyl; R8 is (C5-7)cycloalkyl comprising a heteroatom selected from O, S, SO and SO2; R9 is H or (C1-4)alkyl; o and m represent the ortho or meta position of the substituent Y—CH2; or a pharmaceutically acceptable salt thereof; as well as to the use of said 1-(biphenyl-4-ylmethyl)imidazolidine-2,4-dione derivatives in the treatment of pain such as for example peri-operative pain, chronic pain, neuropathic pain, cancer pain and pain and spasticity associated with multiple sclerosis.

A process for the purification of a tetraol PFPE derivative [tetraol (T)] of formula (I): HO—CH2—CH(OH)—CH2—O—CH2—CF2—O—Rf—CF2—CH2O—CH2—CH(OH)—CH2OH, wherein Rf represents a fluoropolyoxyalkene chain (chain Rf), from a mixture (M) of hydroxyl (per)fluoropolyether derivatives, said mixture comprising said tetraol (T) and at least one hydroxyl (per)fluoropolyether [PFPE (OH)] comprising a chain Rf terminated with at least one end group of formula: —CF2CH2OH; —CF2CH2O—CH(OH)—CH2—O—CH2—CH(OH)—CH2OH; said process comprising: step 1: reacting the mixture (M) with ketones and / or aldehydes so as to selectively protect couples of hydroxyl groups on vicinal carbon atoms by forming corresponding cyclic ketal / acetal derivatives, so as to yield a protected mixture (P); step 2: reacting residual hydroxyl groups of the mixture (P) with suitable functionalizing agents enabling substantial volatility modification, so as to obtain a functionalized protected mixture (Pf); step 3: fractional distillation of the mixture (Pf) so as to isolate the cyclic acetal / ketal derivatives of tetraol (T); and step 4: hydrolyzing the acetal / ketal derivatives of tetraol (T) so as to recover pure tetraol (T).

A transfer hydrogenation process for forming vicinal diols by hydrogenating 1,2-dioxygenated organic compounds using alcohols as the reducing agent instead of the traditional H2 gas. The transfer hydrogenation is carried out under milder conditions of temperature and pressure than is typical for ester hydrogenation with H2. The milder conditions of operation provide benefits, such as lower operating and capital costs for industrial scale production as well as savings in product purification due to the avoidance of by-products from exposure of reaction mixtures and products to high temperatures.

The invention provides ribonucleoside derivatives with novel protecting groups and methods for the preparation of such ribonucleoside derivatives. The general formula (I) of the ribonucleoside derivatives is: wherein R1 is a base of the purine- or pyrimidine-family or a derivative of such a base or any other residue with serves as a nucleobase surrogate, R2 is a proton or a substituted derivative of phosphonic acid, R3 is a proton or a protection-group for the oxygen atom in 5'-position, R4, R5 and R6 are independently alkyl or aryl or a combination of alkyl and aryl or heteroatom, R4, R5 or R6 may also be cyclically connected to each other; and wherein at least one of the R4, R5 or R6 substituents comprises a tertiary C-atom or a heteroatom vicinal to the Si-atom.

The present invention relates to an improved process for diastereoselective synthesis of vicinal diamines (1). The process involves highly regio- and diastereoselective addition of 2-azaallyl anions (4) to N-tert-butanesulfinylimines (5) to produce vicinal diamines (1).

The invention relates to a method for synthesizing 1,2-o-diol compounds. The synthesis method comprises the following steps: (1) using a terminal olefin as a raw material, potassium hydrogen persulfate compound salt as an oxidizing agent, an inorganic salt as a catalyst, mixing water and a ketone organic solvent as a reaction solvent, and reacting at 30-100° C.; (2) After the reaction, add an inorganic base at 0-40°C to make the pH of the reaction system 10-14; (3) continue the reaction at 30-100°C, after the reaction, separate and purify to obtain 1,2-o-diol class of compounds. The synthesis method has mild reaction system, cheap and easy-to-obtain raw materials, environment-friendly oxidant, good reaction selectivity and high conversion rate.

A process for epitaxying GaSe on a [111]-oriented silicon substrate, includes a step of selecting a [111]-oriented silicon substrate resulting from cutting a silicon bar in a miscut direction which is one of the three [11-2] crystallographic directions, the miscut angle (α) being smaller than or equal to 0.1°, the obtained surface of the substrate forming a vicinal surface exhibiting a plurality of terraces and at least one step between two terraces; a passivation step consisting of depositing an atomic bilayer of gallium and of selenium on the vicinal surface of the silicon substrate so as to form a passivated vicinal surface made of silicon-gallium-selenium (Si—Ga—Se), said passivated vicinal surface exhibiting a plurality of passivated terraces and at least one passivated step between two passivated terraces; a step of forming a layer of two-dimensional GaSe by epitaxy on the passivated surface, said formation step comprising a step of nucleation from each passivated step and a step of lateral growth on the passivated terraces from the nuclei obtained in the nucleation step. A structure obtained by means of the epitaxying process is also provided.

Urea-functional organopolysiloxanes containing units of the formulaRnSiO(4-n) / 2  (I),where R is a radical R1 or a radical —OR2 or a radical Q, Q is a urea-functional radical of the formula—R5—[NR4—R6—]xNR4R3  (II),where the radicals R4 are identical or different and are each a radical R4′ or a radical Ru, where R4′ is hydrogen or a monovalent C1-C6-hydrocarbon radical where Ru is radical of the formula —C(═O)—NH2, and where at least one urea-functional radical Q having a radical Ru is present per molecule are prepared by reacting amino-functional organopolysiloxanes comprising units of the formulaR′nSiO(4-n) / 2  (IV),where A is an amino-functional radical of the formula—R5—[NR4′—R6—]xNR4′R3  (V),with the proviso that at least one amino-functional radical A is present per molecule in the organopolysiloxanes made up of units of the formula (III),with ortho-substituted aryl carbamates of the formulaR7—Ar—O—C(═O)—NH2  (VI),where Ar is an ortho-substituted aryl radical.

The invention discloses a biomass organic molecule oxidative cracking catalyst based on modified H-Beta molecular sieve and a preparation method and application thereof. Exchange, so that the active components enter the framework of the dealuminated molecular sieve to act as the adsorption site for Lewis acid and the reaction process, and then use the change of the valence state of the metal ion and its synergistic effect with the H-Beta carrier to effectively improve its cracking activity. The selectivity of the reaction resulted in the construction of an efficient and reusable catalyst that satisfies the C-C bond cleavage of vicinal diols. The catalyst prepared by the invention is used for the oxidative cracking reaction of phenylethylene glycol, the conversion rate of phenylethylene glycol is high, the yield of the oxidative cracking product is more than 95%, and it has unique characteristics in the oxidative cracking reaction of biomass organic molecules. Advantage.

The invention discloses a Zika virus E protein-conjugated vaccine and a preparation method thereof. The specific steps are as follows: 1) oxidizing the adjacent hydroxyl group of β-glucan into an aldehyde group to obtain oxidized β-glucan; 2) adding a linker The bridge compound reacts with the aldehyde group in the oxidized β-glucan to obtain the β-glucan containing the connecting bridge; 3) the Zika virus E protein reacts with the β-glucan containing the connecting bridge, and purifies to obtain the Cavirus E protein conjugate vaccine. The vaccine can induce high levels of cellular and humoral immune responses.

A method for producing a triglyceride including fatty acids with vicinal diesters: (a) providing a triglyceride including fatty acids with epoxide groups; (b) reacting the epoxide groups with carboxylic acid salts under basic conditions to produce a triglyceride including fatty acids with vicinal ester / alkoxides; (c) protonating the vicinal ester / alkoxides to produce a triglyceride including fatty acids with vicinal ester / alcohols; and (d) reacting the vicinal ester / alcohols with carboxylic acids under acidic conditions to produce a triglyceride including fatty acids with vicinal diesters.